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Leejin Lim, Young-Su Jang, Je-Jung Yun, Heesang Song
Phytoncide, nanochemicals extracted from Chamaecyparis obtusa (C. obtusa), is reported to possess many pharmacological activities including immunological stimulating, anti-cancer, antioxidant, and antiinflammatory activities. However, the effect of phytoncide in vascuar diseases, especially on the behavior of vascular smooth muscle cells, has not yet been clearly elucidated. Therefore, in the present study, we investigated the effects of 15 kinds of phytoncide by various extraction conditions from C. obtusa on the proliferation and migration in rat aortic smooth muscle cells (RAoSMCs)...
January 2015: Journal of Nanoscience and Nanotechnology
Shizuka Ito, Yuki Nakamura, Takahiro Noumi, Yuichiro Sasaki
The development of aortic thrombosis without the presence of atheroscrelosis, dissection, or aneurysms is rare. A cancer-related hypercoagulable state is a well-known risk factor for venous thrombosis, however, atrial thrombosis has rarely been reported in cancer patients. Cisplatin-based chemotherapy is known to cause various side-effects. Detecting aortic thrombosis is important because it is a fatal condition. We herein present the first reported case of endo-aortic thrombosis occurring during cisplatin-based chemotherapy for gastric cancer...
2013: Internal Medicine
Takashi Yoshitama, Masato Nakamura, Taro Tsunoda, Yoko Kitagawa, Masanori Shiba, Suguru Yajima, Masamichi Wada, Raisuke Iijima, Rintaro Nakajima, Takuro Takagi, Hitoshi Anzai, Takahiro Nishida, Tetsu Yamaguchi
OBJECTIVE: Insulin resistance has been implicated as an important initiating factor in coronary atherosclerosis. However, associations between insulin resistance and specific morphologic features of atherosclerotic coronary arteries remain unclear. We ultrasonographically evaluated the morphologic features of atherosclerotic coronary arteries in nondiabetic patients with insulin resistance. METHODS: Before intervention, 90 patients with 105 culprit lesions underwent intravascular ultrasound examination through which vessel area, lumen area and plaque area were evaluated...
June 2004: Coronary Artery Disease
Michiko Mori, Fujiko Tsukahara, Toshimasa Yoshioka, Kaoru Irie, Hiroaki Ohta
Several observational studies have shown that estrogen replacement therapy decreases cardiovascular mortality and morbidity in postmenopausal women. However, The Women's Health Initiative (WHI) study has found that women receiving estrogen plus progestin had a significantly higher risk of breast cancer, coronary heart disease, stroke, and pulmonary embolus. In the present study, we examined whether estrogen prevents mechanisms that relate to plaque formation by inhibiting monocyte adhesion to endothelial cells...
June 18, 2004: Life Sciences
Y Noji, K Kajinami, M A Kawashiri, Y Todo, T Horita, A Nohara, T Higashikata, A Inazu, J Koizumi, T Takegoshi, H Mabuchi
To investigate the clinical significance of circulating matrix metalloproteinases (MMPs) and their tissue inhibitos (TIMPs) in patients with premature coronary atheroscrelosis, we studied 53 consecutive male patients with angiographically defined premature (<65 years) and stable coronary artery disease. Plasma levels of MMP-2, MMP-3, MMP-9, TIMP-1, and TIMP-2 were determined in peripheral blood by a sandwich enzyme immunoassay, and the results were compared with those from 133 age-matched control males. There were significant differences in all the MMPs and TIMPs (p<0...
May 2001: Clinical Chemistry and Laboratory Medicine: CCLM
Y Yamamoto, K Oiwa, M Hayashi, K Imai, T Nakamura
Lacunar infarcts are related to occlusion of penetrating arteries. Lipohyalinosis affects the smaller arteries 40-200 microns in diameter, and atherosclerosis involves larger arteries 200-850 microns in diameter. We hypothesized that the processes of thrombus formation might be different among these two kinds of lacuner infarcts, including those caused by lipohyalinosis and atherosclerosis. We studied acute coagulation and fibrinolytic activation in lacunar infarct patients which were divided into two groups according to their size: smaller lacunar group and larger lacunar group...
November 1999: Rinshō Shinkeigaku, Clinical Neurology
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