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https://www.readbyqxmd.com/read/27889570/inhibitor-of-apoptosis-protein-1-regulates-tumor-necrosis-factor-mediated-destruction-of-intestinal-epithelial-cells
#1
Thomas Grabinger, Konstantin J Bode, Janine Demgenski, Carina Seitz, M Eugenia Delgado, Feodora Kostadinova, Cindy Reinhold, Nima Etemadi, Sabine Wilhelm, Matthias Schweinlin, Kay Hänggi, Janin Knop, Christof Hauck, Heike Walles, John Silke, Harald Wajant, Ueli Nachbur, W Wei-Lynn Wong, Thomas Brunner
BACKGROUND AND AIMS: Tumor necrosis factor (TNF) is a cytokine that promotes inflammation and contributes to pathogenesis of inflammatory bowel diseases. Unlike other cells and tissues, intestinal epithelial cells undergo rapid cell death upon exposure to TNF, by unclear mechanisms. We investigated the roles of inhibitor of apoptosis proteins (IAPs) in the regulation of TNF-induced cell death in the intestinal epithelium of mice and intestinal organoids. METHODS: RNA from cell lines and tissues and analyzed by quantitative PCR, protein levels were analyzed by immunoblot assays...
November 23, 2016: Gastroenterology
https://www.readbyqxmd.com/read/27807019/abdominal-tuberculosis-an-old-disease-surprising-young-doctors
#2
Marta David Sousa, Joana Batista, Patricia Pacheco, Vitor Nunes
Tuberculosis remains a worldwide public health concern. Atypical extrapulmonary presentations may delay the diagnosis and treatment. We present the case of an adult woman admitted to the emergency department with bowel obstruction. The putative intraoperative diagnostic hypothesis was ovarian cancer with peritoneal dissemination. Histopathological analysis showed a chronic granulomatous inflammatory disease with acid-fast bacilli. The patient was started on an alternative parenteral antituberculosis drug combination until oral feeding was available...
November 2, 2016: BMJ Case Reports
https://www.readbyqxmd.com/read/27689329/age-and-cellular-context-influence-rectal-prolapse-formation-in-mice-with-caecal-wall-colorectal-cancer-xenografts
#3
Joke Tommelein, Félix Gremonprez, Laurine Verset, Elly De Vlieghere, Glenn Wagemans, Christian Gespach, Tom Boterberg, Pieter Demetter, Wim Ceelen, Marc Bracke, Olivier De Wever
In patients with rectal prolapse is the prevalence of colorectal cancer increased, suggesting that a colorectal tumor may induce rectal prolapse. Establishment of tumor xenografts in immunodeficient mice after orthotopic inoculations of human colorectal cancer cells into the caecal wall is a widely used approach for the study of human colorectal cancer progression and preclinical evaluation of therapeutics. Remarkably, 70% of young mice carrying a COLO320DM caecal tumor showed symptoms of intussusception of the large bowel associated with intestinal lumen obstruction and rectal prolapse...
September 28, 2016: Oncotarget
https://www.readbyqxmd.com/read/26509172/a-media-and-clinic-intervention-to-increase-colorectal-cancer-screening-in-ohio-appalachia
#4
RANDOMIZED CONTROLLED TRIAL
Jessica L Krok-Schoen, Mira L Katz, Jill M Oliveri, Gregory S Young, Michael L Pennell, Paul L Reiter, Jesse J Plascak, Michael D Slater, Janice L Krieger, Cathy M Tatum, Electra D Paskett
OBJECTIVE: To test the effectiveness of a colorectal cancer (CRC) screening intervention among adults living in Ohio Appalachia. METHODS: We conducted a group-randomized trial of a county-level intervention among adults living in 12 Ohio Appalachian counties who received a media campaign and clinic intervention focused on either CRC screening or fruits and vegetables. Participants' percentage within CRC screening guidelines was assessed with cross-sectional surveys conducted annually for four years, and validated with medical record review of screening...
2015: BioMed Research International
https://www.readbyqxmd.com/read/26258401/patients-with-ankylosing-spondylitis-have-increased-cardiovascular-and-cerebrovascular-mortality-a-population-based-study
#5
Nisha Nigil Haroon, J Michael Paterson, Ping Li, Robert D Inman, Nigil Haroon
BACKGROUND: Ankylosing spondylitis (AS) is a chronic inflammatory arthritis affecting the spine in young adults. It is associated with excess cardiovascular and cerebrovascular morbidity. OBJECTIVE: To determine whether patients with AS are at increased risk for cardiovascular and cerebrovascular mortality. DESIGN: Population-based retrospective cohort study using administrative health data. SETTING: Ontario, Canada...
September 15, 2015: Annals of Internal Medicine
https://www.readbyqxmd.com/read/25986630/seeking-health-information-online-association-with-young-australian-women-s-physical-mental-and-reproductive-health
#6
Ingrid Jean Rowlands, Deborah Loxton, Annette Dobson, Gita Devi Mishra
BACKGROUND: Relatively little is known about the extent to which young adults use the Internet as a health information resource and whether there are factors that distinguish between those who do and do not go online for health information. OBJECTIVE: The aim was to identify the sociodemographic, physical, mental, and reproductive health factors associated with young women's use of the Internet for health information. METHODS: We used data from 17,069 young women aged 18-23 years who participated in the Australian Longitudinal Study on Women's Health...
2015: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/25918193/thyroid-cancer-and-t-lymphoblastic-leukemia-in-crohn-disease-a-case-report-and-literature-review
#7
REVIEW
Ja Min Byun, Sun Kyung Baek, Hwi-Joong Yoon, Si-Young Kim, Chi Hoon Maeng, Tae Sung Park, Hyo-Jong Kim, Yun Young Choi, Yu Jin Um
The effectiveness of the tumor necrosis-α (TNF-α) blockade has changed the treatment of several chronic inflammatory diseases, including inflammatory bowel disease; however, this treatment also has disadvantages. The use of immunosuppressants in combination with infliximab has been associated with greater risk of developing malignant neoplasms. Herein, we report the case of a 33-year-old ethnic Korean man with Crohn disease (CD) who developed papillary thyroid carcinoma (PTC) and, subsequently, T-cell acute lymphoblastic leukemia (ALL) after approximately 16...
2015: Laboratory Medicine
https://www.readbyqxmd.com/read/25370966/the-role-of-t-cell-potassium-channels-kv1-3-and-kca3-1-in-the-inflammatory-cascade-in-ulcerative-colitis
#8
REVIEW
Lars Koch Hansen
Ulcerative Colitis (UC) is a chronic inflammatory bowel disease located in the mucosa of the large bowel. UC often affects young adults between 15 and 40 years of age with no pre-dominant sex. Over time, incidence rates are steadily increasing and the cause of the disease remains unknown. Symptoms are general discomfort and bloody diarrhea. UC is diagnosed by endoscopic examination of the large bowel, where different hallmarks are found. It is of great importance that attacks/relapses are treated medically, as flares may cause death due to inflammatory destruction of the mucosa and perforation of the colon leading to extreme infection of the abdominal cavity...
November 2014: Danish Medical Journal
https://www.readbyqxmd.com/read/25135754/clinical-utility-and-diagnostic-accuracy-of-faecal-calprotectin-for-ibd-at-first-presentation-to-gastroenterology-services-in-adults-aged-16-50-years
#9
MULTICENTER STUDY
Nicholas A Kennedy, Annalie Clark, Andrew Walkden, Jeff C W Chang, Federica Fascí-Spurio, Martina Muscat, Brydon W Gordon, Kathleen Kingstone, Jack Satsangi, Ian D R Arnott, Charlie W Lees
BACKGROUND: Distinguishing inflammatory bowel disease (IBD) from functional gastrointestinal (GI) disease remains an important issue for gastroenterologists and primary care physicians, and may be difficult on the basis of symptoms alone. Faecal calprotectin (FC) is a surrogate marker for intestinal inflammation but not cancer. AIM: This large retrospective study aimed to determine the most effective use of FC in patients aged 16-50 presenting with GI symptoms. METHODS: FC results were obtained for patients presenting to the GI clinics in Edinburgh between 2005 and 2009 from the Edinburgh Faecal Calprotectin Registry containing FCs from >16,000 patients...
January 2015: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/24969294/inflammatory-bowel-disease-and-neoplasia-in-children
#10
REVIEW
Paul A Rufo
Advances in our understanding of the pathophysiology of ulcerative colitis and Crohn's disease have led to the widespread use of increasingly potent immunosuppressive therapies. This has greatly benefited the majority of patients with inflammatory bowel disease (IBD) and has resulted in improved overall clinical outcomes and quality of life. However, a growing body of data now indicates that long-term use of these agents may at the same time place patients at risk for a number of adverse effects, including colorectal and skin cancer, as well as lymphoma...
2014: Digestive Diseases
https://www.readbyqxmd.com/read/24833941/inflammatory-bowel-disease-an-expanding-global-health-problem
#11
REVIEW
Amosy E M'Koma
This review provides a summary of the global epidemiology of inflammatory bowel diseases (IBD). It is now clear that IBD is increasing worldwide and has become a global emergence disease. IBD, which includes Crohn's disease (CD) and ulcerative colitis (UC), has been considered a problem in industrial-urbanized societies and attributed largely to a Westernized lifestyle and other associated environmental factors. Its incidence and prevalence in developing countries is steadily rising and has been attributed to the rapid modernization and Westernization of the population...
2013: Clinical Medicine Insights. Gastroenterology
https://www.readbyqxmd.com/read/24586848/reconstructing-the-life-of-an-unknown-ca-500-years-old-south-american-inca-mummy-multidisciplinary-study-of-a-peruvian-inca-mummy-suggests-severe-chagas-disease-and-ritual-homicide
#12
Stephanie Panzer, Oliver Peschel, Brigitte Haas-Gebhard, Beatrice E Bachmeier, Carsten M Pusch, Andreas G Nerlich
The paleopathological, paleoradiological, histological, molecular and forensic investigation of a female mummy (radiocarbon dated 1451-1642 AD) provides circumstantial evidence for massive skull trauma affecting a young adult female individual shortly before death along with chronic infection by Trypanosoma cruzi (Chagas disease). The mummy (initially assumed to be a German bog body) was localized by stable isotope analysis to South America at/near the Peruvian/Northern Chilean coast line. This is further supported by New World camelid fibers attached to her plaits, typical Inca-type skull deformation and the type of Wormian bone at her occiput...
2014: PloS One
https://www.readbyqxmd.com/read/24393412/the-increasing-incidence-of-young-onset-colorectal-cancer-a-call-to-action
#13
Dennis J Ahnen, Sally W Wade, Whitney F Jones, Randa Sifri, Jose Mendoza Silveiras, Jasmine Greenamyer, Stephanie Guiffre, Jennifer Axilbund, Andrew Spiegel, Y Nancy You
In the United States, colorectal cancer (CRC) is the third most common and second most lethal cancer. More than one-tenth of CRC cases (11% of colon cancers and 18% of rectal cancers) have a young onset (ie, occurring in individuals younger than 50 years). The CRC incidence and mortality rates are decreasing among all age groups older than 50 years, yet increasing in younger individuals for whom screening use is limited and key symptoms may go unrecognized. Familial syndromes account for approximately 20% of young-onset CRCs, and the remainder are typically microsatellite stable cancers, which are more commonly diploid than similar tumors in older individuals...
February 2014: Mayo Clinic Proceedings
https://www.readbyqxmd.com/read/24358421/biopsy-case-mix-and-diagnostic-yield-at-a-malawian-central-hospital
#14
P Mtonga, L Masamba, D Milner, L N Shulman, R Nyirenda, K Mwafulirwa
Cancer is a major disease burden worldwide resulting in high morbidity and mortality. It is the leading cause of mortality in developed countries and is one of the three leading causes of death for adults in developing countries. Pathological examination of tissue biopsies with histological confirmation of a correct cancer diagnosis is central to cancer care. Without an accurate and specific pathologic diagnosis, effective treatment cannot be planned or delivered. In addition, there are marked geographical variations in incidence of cancer overall, and of the specific cancers seen...
September 2013: Malawi Medical Journal: the Journal of Medical Association of Malawi
https://www.readbyqxmd.com/read/24142823/adolescent-and-young-adult-colorectal-cancer
#15
REVIEW
Joleen M Hubbard, Axel Grothey
Although the overall incidence of colorectal cancer (CRC) in adolescents and young adults (AYAs) is low, it has seen an increase over the past 2 to 3 decades, which contrasts with the trend of decreased incidence in the older population. This phenomenon is conceivably caused by a lack of routine CRC screening in the young population and lifestyle issues, including the obesity epidemic and dietary factors. Hereditary genetic syndromes (eg, familial adenomatous polyposis and hereditary nonpolyposis colorectal cancer syndrome) and known predisposing medical conditions (eg, inflammatory bowel disease) account for only a minority of CRC cases in AYA...
October 1, 2013: Journal of the National Comprehensive Cancer Network: JNCCN
https://www.readbyqxmd.com/read/23978954/cancer-risk-in-inflammatory-bowel-disease-according-to-patient-phenotype-and-treatment-a-danish-population-based-cohort-study
#16
Tine Jess, Erzsébet Horváth-Puhó, Jan Fallingborg, Henrik H Rasmussen, Bent A Jacobsen
OBJECTIVES: Population-based studies of site-specific cancer risk in patients with inflammatory bowel disease (IBD) according to IBD phenotype and treatment are lacking. We studied cancer risk in a well-characterized population-based IBD cohort from North Jutland County, Denmark. METHODS: A total of 1,515 patients were diagnosed with ulcerative colitis (UC) and 810 with Crohn's disease (CD) during 1978-2002. Patients were followed until 31 December 2010 for occurrence of incident cancer, identified in the Danish Cancer Registry...
December 2013: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/23969514/endoscopic-characteristics-and-causes-of-misdiagnosis-of-intestinal-schistosomiasis
#17
Chuncui Ye, Shiyun Tan, Lin Jiang, Ming Li, Peng Sun, Lei Shen, Hesheng Luo
The aim of this study was to determine the clinical and endoscopic manifestations, and pathological characteristics of intestinal schistosomiasis in China, in order to raise awareness of intestinal schistosomiasis and prevent misdiagnosis and missed diagnosis. The retrospective analysis of clinical and endoscopic manifestations, and histopathological characteristics, were conducted for 96 patients with intestinal schistosomiasis. Among these patients, 21 lived in areas that were not infected with Schistosoma and 25 (26%) had no history of schistosome infection or contact with infected water...
October 2013: Molecular Medicine Reports
https://www.readbyqxmd.com/read/23894567/medical-risk-factors-associated-with-cholangiocarcinoma-in-taiwan-a-population-based-case-control-study
#18
Jeffrey S Chang, Chia-Rung Tsai, Li-Tzong Chen
BACKGROUND: Cholangiocarcinoma, including intra- and extrahepatic cholangiocarcinoma, is a rare but highly lethal cancer. Despite effort in finding the risk factors of cholangiocarcinoma, the causes of most cholangiocarcinoma remain unknown. This study utilized a population-based case-control design using data from the National Health Insurance Research Database (NHIRD) of Taiwan to assess the medical conditions associated with cholangiocarcinoma. METHODS: 5,157 incident cases of cholangiocarcinoma diagnosed during 2004 to 2008 and 20,628 controls matched to the cases on sex, age, and time of diagnosis (reference date for the controls) were identified from the NHIRD...
2013: PloS One
https://www.readbyqxmd.com/read/23846486/a-pilot-study-to-evaluate-the-safety-and-efficacy-of-an-oral-dose-of-epigallocatechin-3-gallate-rich-polyphenon-e-in-patients-with-mild-to-moderate-ulcerative-colitis
#19
RANDOMIZED CONTROLLED TRIAL
Gerald W Dryden, Allan Lam, Karen Beatty, Hassan H Qazzaz, Craig J McClain
BACKGROUND: Green tea and its main polyphenolic component, (-)-epigallocatechin-3-gallate (EGCG), exert powerful anti-inflammatory effects that are protective against both inflammatory diseases and cancer. Research with animal and human cell lines provide plausible support for these claims. Poor absorption results in low systemic bioavailability of EGCG after oral administration but high colonic mucosal exposure. METHODS: Patients with mild to moderate ulcerative colitis (UC) were randomized to daily doses of oral Polyphenon E (400 mg or 800 mg of total EGCG daily, administered in split doses) or placebo in a double-blinded, placebo-controlled pilot study...
August 2013: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/23765177/cause-specific-mortality-and-30-year-relative-survival-of-crohn-s-disease-and-ulcerative-colitis
#20
COMPARATIVE STUDY
Christian P Selinger, Jane Andrews, Owen F Dent, Ian Norton, Brian Jones, Charles McDonald, James Cowlishaw, Gavin Barr, Warwick Selby, Rupert W Leong
BACKGROUND: Data from the northern hemisphere suggest that patients with ulcerative colitis (UC) have similar survival to the general population, whereas mortality in Crohn's disease (CD) is increased by up to 50%. There is a paucity of data from the southern hemisphere, especially in Australia. METHODS: A prevalence cohort (1977-1992) of patients with inflammatory bowel disease (IBD) diagnosed after 1970 was studied. Survival status data and causes of death up to December 2010 were extracted from the National Death Index...
August 2013: Inflammatory Bowel Diseases
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