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Economic evaluation heart failure developing countries

Rebeca Acin-Perez, Ana Victoria Lechuga-Vieco, Maria Del Mar Muñoz, Rocío Nieto-Arellano, Carlos Torroja, Fátima Sánchez-Cabo, Concepción Jiménez, Andrés González-Guerra, Isabel Carrascoso, Cristiane Benincá, Pedro M Quiros, Carlos López-Otín, José María Castellano, Jesús Ruíz-Cabello, Luis Jesús Jiménez-Borreguero, José Antonio Enríquez
Heart failure (HF) is a major health and economic burden in developed countries. It has been proposed that the pathogenesis of HF may involve the action of mitochondria. We evaluate three different mouse models of HF: tachycardiomyopathy, HF with preserved left ventricular (LV) ejection fraction (LVEF), and LV myocardial ischemia and hypertrophy. Regardless of whether LVEF is preserved, our results indicate that the three models share common features: an increase in mitochondrial reactive oxygen species followed by ultrastructural alterations in the mitochondrial cristae and loss of mitochondrial integrity that lead to cardiomyocyte death...
March 28, 2018: Science Translational Medicine
Khal Salem, Osama ElKhateeb
AIMS: The two components of disability-adjusted life year (DALY), years of life lost (YLL) and years lived with disability (YLD), are underutilized in evaluating heart failure with reduced ejection fraction (HFrEF) and in assessing the global burden of disease. We aim to describe both the direct (medical) and the indirect (morbidity and mortality) inpatient cost of congestive heart failure in a high-income non-Organization for Economic Cooperation and Development Middle Eastern country in relation to YLL and YLD...
August 2017: ESC Heart Failure
Emiliane Nogueira de Souza, Luis Eduardo Rohde, Karen Brasil Ruschel, Cláudia Mota Mussi, Luis Beck-da-Silva, Andréia Biolo, Nadine Clausell, Eneida Rejane Rabelo-Silva
AIMS: Home-based interventions for heart failure (HF) patients might be particularly effective in middle-income countries, where social, cultural, and economic constraints limit the effectiveness of HF treatment outside the hospital environment. METHODS AND RESULTS: HELEN-II was a randomized clinical trial conducted in Brazil designed to evaluate the clinical efficacy of a nurse-based strategy, started after discharge following an acute decompensated HF (ADHF) admission...
September 2014: European Journal of Heart Failure
F S Mennini, A Marcellusi, J M Graf von der Schulenburg, A Gray, P Levy, P Sciattella, M Soro, G Staffiero, J Zeidler, A Maggioni, R E Schmieder
The financial burden for EU health systems associated with cardiovascular disease (CV) has been estimated to be nearly €110 billion in 2006, corresponding to 10% of total healthcare expenditure across EU or a mean €223 annual cost per capita. The main purpose of this study is to estimate the costs related to hypertension and the economic impact of increasing adherence to anti-hypertensive therapy in five European countries (Italy, Germany, France, Spain and England). A probabilistic prevalence-based decision tree model was developed to estimate the direct costs of CV related to hypertension (CV defined as: stroke, heart attack, heart failure) in five European countries...
January 2015: European Journal of Health Economics: HEPAC: Health Economics in Prevention and Care
Julius A Ogeng'o, Patrick M Gatonga, Beda O Olabu, Diana K Nyamweya, Dennis Ong'era
BACKGROUND: Heart failure in children is a common cause of morbidity and mortality, with high socio-economic burden. Its pattern varies between countries but reports from Africa are few. The data are important to inform management and prevention strategies. OBJECTIVE: To describe the pattern of congestive heart failure in a Kenyan paediatric population. METHODS: This was a retrospective study done at Kenyatta National Hospital, Nairobi Kenya...
May 2013: Cardiovascular Journal of Africa
Amir Shroufi, Rajiv Chowdhury, Raghupathy Anchala, Sarah Stevens, Patricia Blanco, Tha Han, Louis Niessen, Oscar H Franco
BACKGROUND: While there is good evidence to show that behavioural and lifestyle interventions can reduce cardiovascular disease risk factors in affluent settings, less evidence exists in lower income settings.This study systematically assesses the evidence on cost-effectiveness for preventive cardiovascular interventions in low and middle-income settings. METHODS: HASH(0x3827e98) DESIGN: Systematic review of economic evaluations on interventions for prevention of cardiovascular disease...
March 28, 2013: BMC Public Health
Rebecca Thomas, Alyson Huntley, Mala Mann, Dyfed Huws, Shantini Paranjothy, Glyn Elwyn, Sarah Purdy
UNLABELLED: Unplanned admissions for heart failure are common and some are considered preventable. OBJECTIVE: Undertake a systematic literature review and meta-analysis to evaluate the effectiveness of specialist clinics in reducing unplanned hospital admissions in people with heart failure. DATA SOURCES: 18 databases were searched from inception to June 2010. Relevant websites and reference lists of included studies were checked for additional publications...
February 2013: Heart: Official Journal of the British Cardiac Society
Johanna B Roos, Sagar N Doshi, Thomas Konorza, Igor Palacios, Ted Schreiber, Oleg V Borisenko, Jose P S Henriques
OBJECTIVE: A new and smaller percutaneous ventricular assist device (pVAD, Impella, Abiomed, Danvers, MA) has been developed to provide circulatory support in hemodynamically unstable patients and to prevent hemodynamic collapse during high-risk percutaneous coronary interventions (PCI). The objective of the study was to assess the cost-effectiveness of this specific device compared to the intra-aortic balloon pump (IABP) from the European perspective. Additional analysis on extracorporeal membrane oxygenation was conducted for observational purposes only, given its use in some European countries...
2013: Journal of Medical Economics
Örjan Åkerborg, Jonas Nilsson, Stephanie Bascle, Peter Lindgren, Matthew Reynolds
BACKGROUND: Dronedarone is a therapy for the treatment of patients with paroxysmal and persistent atrial fibrillation or atrial flutter. According to results in the ATHENA trial, dronedarone on top of standard of care (SOC) decreases the risk of cardiovascular hospitalizations or death by 24% compared with SOC alone. OBJECTIVES: A patient-level health economic model was developed to evaluate the cost-effectiveness of dronedarone on top of SOC versus SOC alone. METHODS: The risk of experiencing stroke, congestive heart failure, acute coronary syndromes, treatment discontinuation, and death was modeled by separate health states, whereas adverse events were included as 1-time cost and utility decrements...
August 2012: Clinical Therapeutics
Alexander Goehler, Benjamin P Geisler, Jennifer M Manne, Beate Jahn, Annette Conrads-Frank, Petra Schnell-Inderst, G Scott Gazelle, Uwe Siebert
Chronic heart failure (CHF) is a critical public health issue with increasing effect on the healthcare budgets of developed countries. Various decision-analytic modelling approaches exist to estimate the cost effectiveness of health technologies for CHF. We sought to systematically identify these models and describe their structures. We performed a systematic literature review in MEDLINE/PreMEDLINE, EMBASE, EconLit and the Cost-Effectiveness Analysis Registry using a combination of search terms for CHF and decision-analytic models...
September 2011: PharmacoEconomics
Rodrigo Antonini Ribeiro, Steffan Frosi Stella, Leandro Ioschpe Zimerman, Maurício Pimentel, Luis Eduardo Rohde, Carisi Anne Polanczyk
BACKGROUND: Many randomized clinical trials have demonstrated the effectiveness of the implantable cardioverter-defibrillator (ICDs) in death reduction of chronic heart failure (CHF) patients. Some developed countries studies have evaluated its cost-effectiveness, but these data are not applicable to Brazil. OBJECTIVE: To evaluate the cost-effectiveness of ICD in CHF patients under two perspectives in Brazil: public and supplementary health systems. METHODS: A Markov model was developed to analyze the incremental cost-effectiveness ratio (ICER) of ICD compared to conventional therapy in patients with CHF...
October 2010: Arquivos Brasileiros de Cardiologia
Jose E Sánchez, Teresa Ortega, Carmen Rodríguez, Beatriz Díaz-Molina, Maria Martín, Carmen Garcia-Cueto, Pedro Vidau, Emilio Gago, Francisco Ortega
BACKGROUND: Heart failure (HF) is a major health problem in developed countries. HF is a progressive, lethal disorder, even with adequate treatment. There exists a vicious circle in the pathophysiology of HF that perpetuates and magnifies the problem. Concomitant fluid accumulation may worsen the congestive HF, it is responsible for numerous hospitalizations and it is an important cause of mortality. In this situation, any means of fluid removal may aid in the management of these patients...
February 2010: Nephrology, Dialysis, Transplantation
C Cunningham-Myrie, M Reid, T E Forrester
OBJECTIVE: Non-communicable Diseases (NCDs) are leading threats to health and well-being in the Caribbean. A study was undertaken in the latter part of 2005 to compute the economic burden of diabetes mellitus and hypertension within the Caribbean Community and Common Market (CARICOM). This report critiques the quality and availability of health information which can be used to facilitate cost burden analysis of diabetes mellitus and hypertension. METHODS: A form was developed and disseminated to obtain epidemiological and health service utilization data...
September 2008: West Indian Medical Journal
Gregorio Montalvo, Fausto Avanzini, Mariella Anselmi, Rosanna Prandi, Samuel Ibarra, Monica Marquez, Daniela Armani, Juan-Martín Moreira, Cynthia Caicedo, Maria Carla Roncaglioni, Fabio Colombo, Paola Camisasca, Valentina Milani, Simon Quimì, Felix Gonzabay, Gianni Tognoni
OBJECTIVES: To explore the predictive power of a risk stratification method for people with hypertension based on "essential" procedures (that is, available in economically less developed areas of the world), comparing it in the same population with the results given by the method suggested by the 1999 World Health Organization-International Society of Hypertension (WHO-ISH) guidelines. DESIGN: Prospective cohort study of outcomes according to cardiovascular risk profile at baseline...
2008: BMJ: British Medical Journal
Shelby D Reed, Joëlle Y Friedman, Ari Gnanasakthy, Kevin A Schulman
OBJECTIVES: To develop and evaluate strategies for estimating hospitalization costs in multinational clinical trials. METHODS: Hospital cost estimates for eleven diagnoses were collected from twelve countries participating in a trial of therapies for congestive heart failure. Estimates were combined with U.S.-based diagnosis-related group weights to compute country-specific unit cost estimates for all reasons for hospitalization. Variations of hospital costing methods were developed...
2003: International Journal of Technology Assessment in Health Care
W L Boyko, H A Glick, K A Schulman
No abstract text is available yet for this article.
May 1999: American Heart Journal
K A Schulman, H Glick, M Buxton, M Sculpher, M Backhouse, L Bell, J M Eisenberg
Prospective economic assessments of new pharmaceutical therapies are increasingly being incorporated into phase III clinical trials. We report on the design of an economic evaluation integrated into the Flolan International Randomized Survival Trial (FIRST). Economic evaluation was considered a critical component of the assessment of this therapy given the resources required to administer epoprostenol (Flolan), a therapy that would require lifelong continuous intravenous infusion. Economic secondary endpoints were incorporated in the clinical trial...
August 1996: Controlled Clinical Trials
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