keyword
https://read.qxmd.com/read/37541742/interstitial-lung-disease-with-and-without-progressive-fibrosing-phenotype-in-patients-with-idiopathic-inflammatory-myopathies-data-from-a-large-multicentric-cohort
#21
JOURNAL ARTICLE
Elisabetta Zanatta, Elisabetta Cocconcelli, Gioele Castelli, Chiara Giraudo, Anna Sara Fraia, Elena De Zorzi, Mariele Gatto, Luana Ienna, Elena Treppo, Danilo Malandrino, Lorenzo Cereser, Giacomo Emmi, Federico Giannelli, Serena Bellani, Andrea Martini, Beatrice Moccaldi, Anna Ghirardello, Jérôme Avouac, Luca Quartuccio, Yannick Allanore, Andrea Doria, Paolo Spagnolo, Elisabetta Balestro, Luca Iaccarino
OBJECTIVES: Patients with connective tissue diseases can develop interstitial lung disease (ILD), leading to a progressive fibrosing ILD (PF-ILD) phenotype in some cases. We aimed to investigate the occurrence of PF-ILD in idiopathic inflammatory myopathies (IIMs), and factors potentially predicting this phenotype. Secondary aims were to assess the radiological pattern and factors associated with IIMs-ILD. METHODS: Patients with IIMs from our multicentric prospective cohort were retrospectively evaluated...
August 2023: RMD Open
https://read.qxmd.com/read/37432024/igm-nephropathy-in-a-patient-with-dermatomyositis-following-covid-19-vaccination-a-case-report
#22
Mohammadkian Zarafshani, Maryam Loghman, Monir Sadat Hakemi, Fatemeh Nili, Sara Beikmohamadi Hezaveh, Marzie Tabatabaie Nejad, Seyedeh Tahereh Faezi
BACKGROUND: Dermatomyositis (DM) is a systemic autoimmune disease characterized by distinct skin lesions and a clinically heterogeneous constellation of systemic manifestations. This disease poses a challenge to clinicians because of its rarity, diverse clinical presentations, and variable organ involvement, resulting from an autoimmune attack on affected organs, which could be triggered by environmental factors in genetically susceptible individuals. Renal involvement is rare, with immunoglobulin M (IgM) nephropathy yet to be reported in patients with DM...
July 11, 2023: International Journal of Rheumatic Diseases
https://read.qxmd.com/read/37414136/heliotrope-rash-and-puffy-fingers-due-to-kikuchi-fujimoto-disease
#23
JOURNAL ARTICLE
Hiroyuki Yamaguchi, Noboru Hagino
No abstract text is available yet for this article.
July 4, 2023: Joint, Bone, Spine: Revue du Rhumatisme
https://read.qxmd.com/read/37405442/long-standing-and-poorly-controlled-disease-in-juvenile-dermatomyositis-is-associated-with-calcinosis-a-real-world-experience-from-a-low-middle-income-country
#24
JOURNAL ARTICLE
Pankti Mehta, Able Lawrence, Latika Gupta, Durga P Misra, Vikas Agarwal, Ramnath Misra, Amita Aggarwal
To study the prevalence and predictors of calcinosis in Juvenile Dermatomyositis (JDM). Medical records over 20 years at a tertiary care rheumatology center in Northern India were reviewed to identify patients with JDM and clinical details were recorded. The frequency of calcinosis, predictors, specific treatment, and its outcomes were studied. Data are expressed as median and interquartile range. In eighty-six patients (median age 10) of JDM, the frequency of calcinosis was 18.2% (8.5% at presentation)...
July 5, 2023: Rheumatology International
https://read.qxmd.com/read/37393558/anti-ku-antibody-positive-systemic-sclerosis-and-idiopathic-inflammatory-myopathies-overlap-syndrome-in-children-a-report-of-two-cases-and-a-review-of-the-literature
#25
REVIEW
Saki Kanda, Asami Shimbo, Yoshitaka Nakamura, Ryosuke Matsuno, Shuya Kaneko, Hitoshi Irabu, Kazunari Kaneko, Masaki Shimizu
The occurrence of anti-Ku antibody-positive idiopathic inflammatory myopathy (IIM) in pediatric patients is rare, and therefore, the clinical phenotypes of this disease in such patients remain obscure. We herein report two cases of Japanese female pediatric patients with anti-Ku antibody-positive IIM. One case was unique in that it was complicated by pericardial effusion. Another patient had severe and refractory myositis with immune-mediated necrotizing myopathy. In addition, we reviewed literatures involving a total of 11 pediatric patients with anti-Ku antibody-positive IIM...
July 2, 2023: Clinical Rheumatology
https://read.qxmd.com/read/37366458/a-case-of-hemorrhagic-myositis-associated-with-prophylactic-heparin-use-in-dermatomyositis
#26
Mery Bartl, Jose G Gomez Casanovas, Christine E Loftis, Laura Rincon-Rueda, Andres R Suarez Parraga
Dermatomyositis (DM) is a rare systemic autoimmune disease that is associated with inflammation of the skin and muscles. It typically presents with weakness of the proximal muscles along with characteristic skin lesions such as Gottron's papules and heliotrope rash. One of the most feared complications of this disease is the appearance of spontaneous hemorrhagic myositis, as most reported cases are fatal. The mechanism or risk factors of this condition have not been elucidated; however, prophylactic anticoagulation has been correlated with it in previous case reports, although idiopathic hemorrhagic myositis may also be present...
May 2023: Curēus
https://read.qxmd.com/read/37243455/dermatomyositis-and-crohn-s-disease-case-report
#27
Ana Neves, Inês Mendonça, José Marques, José Costa, Jorge Almeida
Immune-mediated diseases tend to overlap in ways that are not completely understood. When a presentation is not entirely explained by a former condition, other hypotheses should arise. Additionally, the activity of 2 overlapping immune-mediated conditions is not always associated. We present an unusual association between Crohn's disease and dermatomyositis in a 28-year-old man. The patient presented with a 2-month history of proximal muscle weakness and a skin rash with heliotrope periorbital edema. Since the patient had already been diagnosed with Crohn's disease, he was under immunosuppressive therapy, and he had a family history of psoriasis, the diagnosis was not immediate and required an integrative approach...
May 27, 2023: International Journal of Rheumatic Diseases
https://read.qxmd.com/read/37153943/dermatomyositis-a-comprehensive-review-of-clinical-manifestations-serological-features-and-therapeutic-approaches
#28
REVIEW
Dario Didona, Farzan Solimani, Raffaele D Caposiena Caro, Antonio M Sequeira Santos, Julia Hinterseher, Jacqueline Kussini, Tomas Cunha, Michael Hertl, Biagio Didona
Dermatomyositis (DM) is an autoimmune disorder, which belongs to a group of rare autoimmune dermatoses characterized by different skin features and variable muscle involvement. We recognize four main variants of DM: classic DM, clinically amyopathic DM, paraneoplastic DM, and juvenile DM. Clinically, patients show several skin features, but heliotrope rash, and violaceous papules located at the interphalangeal or metacarpophalangeal joints (Gottron's papules) are the most frequently observed. Together with skin features, patients show muscle involvement, most commonly with symmetrical weakness of the proximal muscles...
April 2023: Italian journal of dermatology and venereology
https://read.qxmd.com/read/37042120/clinical-features-and-risk-factors-of-lung-cancer-in-elderly-patients-with-dermatomyositis
#29
JOURNAL ARTICLE
Baiyu Zhou, Shu Li, Xi Xie, Suqing Xu, Fen Li, Liuxin Long
BACKGROUND: Although there are concerns about the association between dermatomyositis (DM) and malignancy, the clinical features in elderly DM patients with lung cancer are largely unknown. Here, we elucidated the clinical features and risk factors of lung cancer in elderly DM patients. METHODS: The data of elderly DM patients (≥65 years old) with or without lung cancer admitted to the Second Xiangya Hospital, Central South University from January 2016 to November 2022 were retrospectively analyzed...
April 12, 2023: Thoracic Cancer
https://read.qxmd.com/read/36962887/the-association-between-clinical-subclinical-features-and-autoantibody-profile-in-vietnamese-dermatomyositis-patients
#30
JOURNAL ARTICLE
My Huyen Le, Hoa Thi Dinh, Thu Thi Hoai Le, Phuong Thi Hoang, Minh Nguyet Vu, Doanh Huu Le
There is still a lack of research in Vietnam on the autoantibody profile of dermatomyositis (DM) and its association with clinical and subclinical characteristics. Therefore, we conducted this study to investigate clinical and subclinical correlations with autoantibodies in DM patients. 72 DM patients at Vietnam National Hospital of Dermatology and Venereology (NHDV) from March 2019 to September 2021 were included in this cross-sectional study. Clinical manifestations and laboratory test results of the patients were obtained at the time of visit...
2023: PLOS Glob Public Health
https://read.qxmd.com/read/36809089/characteristics-of-patients-with-juvenile-dermatomyositis-from-2001-2021-at-a-tertiary-care-center
#31
JOURNAL ARTICLE
Elanee Simmons, Maha Kazmi, Machelle Wilson, Maija Kiuru, Danielle M Tartar
BACKGROUND: Juvenile dermatomyositis (JDM) is the most common inflammatory myopathy in the pediatric population and can represent a medical emergency. However, many features of JDM remain poorly understood, disease presentation is highly variable, and predictors of disease course have yet to be identified. METHODS: This retrospective chart review included 47 JDM patients seen at a tertiary care center over a 20-year period. Characteristics such as demographics, clinical signs and symptoms, antibody positivity, dermatopathology features, and treatments were recorded...
December 15, 2022: Dermatology Online Journal
https://read.qxmd.com/read/36802052/clinical-characteristics-of-dermatomyositis-with-interstitial-lung-disease-a-retrospective-case-control-study
#32
JOURNAL ARTICLE
Chenghua Weng, Zongnan Ding, Yiqun Zhou, Qinyi Yang, Leixi Xue, Lei Zhang, Gang Wang, Zhichun Liu
INTRODUCTION: Interstitial lung disease (ILD) is a common complication of dermatomyositis (DM) and one of the main risk factors for poor prognosis in DM patients. The aim of this study was to reveal the clinical characteristics of DM patients with ILD. METHODS: Clinical data from the Second Affiliated Hospital of Soochow University were used to conduct a retrospective case-control study. Univariate and multivariate logistic regression analysis were performed to identify risk factors for ILD in DM...
February 18, 2023: Rheumatology and Therapy
https://read.qxmd.com/read/36721601/rehabilitation-and-exercise-in-dermatomyositis-a-case-report-and-narrative-review-of-the-literature
#33
Duarte Calado, Frederico Moeda, Madjer Hatia, Sérgio Pinho, Marta Amaral-Silva
Dermatomyositis (DM) is an idiopathic inflammatory myopathy most commonly characterized by proximal, progressive, symmetrical muscle weakness, as well as specific dermatological manifestations. The presence of nuclear matrix protein 2 (NXP-2) autoantibodies is predominantly associated with joint contractures and calcinosis. A 19-year-old female was diagnosed with DM with positive anti-NXP-2 autoantibodies. She had severe joint involvement of the shoulders, elbows, wrists, and ankles, and the presence of calcinosis was documented on radiographs...
December 2022: Curēus
https://read.qxmd.com/read/36638210/chloroplasts-in-plant-cells-show-active-glassy-behavior-under-low-light-conditions
#34
JOURNAL ARTICLE
Nico Schramma, Cintia Perugachi Israëls, Maziyar Jalaal
Plants have developed intricate mechanisms to adapt to changing light conditions. Besides phototropism and heliotropism (differential growth toward light and diurnal motion with respect to sunlight, respectively), chloroplast motion acts as a fast mechanism to change the intracellular structure of leaf cells. While chloroplasts move toward the sides of the plant cell to avoid strong light, they accumulate and spread out into a layer on the bottom of the cell at low light to increase the light absorption efficiency...
January 17, 2023: Proceedings of the National Academy of Sciences of the United States of America
https://read.qxmd.com/read/36592144/characteristics-of-anti-transcriptional-intermediary-factor-1-gamma-autoantibody-positive-dermatomyositis-patients-in-singapore
#35
JOURNAL ARTICLE
Choon Guan Chua, Jia Zhen Low, Wei Yen Lim, Mona Manghani
INTRODUCTION: This study aimed to determine the clinical profile and outcome of anti-transcriptional intermediary factor 1 gamma autoantibody (anti-TIF1-γ Ab)-positive dermatomyositis patients and propose cancer screening programmes based on regional cancer trends. METHOD: Data on history, physical findings and investigations were collected using chart review on dermatomyositis patients seen at a tertiary hospital in Singapore from 1 January 2015 to 30 June 2021...
December 2022: Annals of the Academy of Medicine, Singapore
https://read.qxmd.com/read/36544169/proximal-muscle-weakness-as-the-sole-manifestation-of-cushing-s-disease-misdiagnosed-as-dermatomyositis-a-case-report
#36
JOURNAL ARTICLE
Marjan Jeddi, Mesbah Shams
BACKGROUND: Cushing's syndrome consists of signs and symptoms related to prolonged exposure to high levels of glucocorticoid, and should be considered in individuals with the discriminatory signs and symptoms. Proximal myopathy is an important discriminatory sign. CASE PRESENTATION: We report the case of a 36-year-old Iranian man who presented with proximal muscle weakness. He visited a rheumatologist in an outpatient clinic, and according to proximal muscle weakness and heliotrope rash (based on the rheumatologist's notes) with the impression of dermatomyositis, prednisolone and azathioprine were prescribed for him that did not improve his clinical status and he was gradually wheelchair dependent...
December 22, 2022: Journal of Medical Case Reports
https://read.qxmd.com/read/36542793/-anti-mda5-dermatomyositis-literature-review
#37
REVIEW
Sirenia Alejandra Castro-Molina, Silvia Méndez-Flores
Dermatomyositis positive anti-melanoma differentiation-associated gene 5 (anti-MDA5 DM) is a rare disease that represents less than 2%. The prevalence of anti-MDA5 DM ranges from 7 to 60%, with higher prevalence in Asian (11-60%) and women. The clinical picture may be variable and is accompanied by the typical features of dermatomyositis, such as periorbital heliotrope (blue-purple) rash with edema, erythematous rash on the face, or the anterior chest (in a V-sign), and back and shoulders (in a shawl sign), violaceous papules or plaques located on the dorsal part of the metacarpophalangeal or interphalangeal joints, which are pathognomonic by definition; yet, one of the most striking signs is the painful ulceration skin that is found in 82% of cases, which is deep and in punching holes or showing hyperkeratotic crusts...
January 2, 2023: Revista Médica del Instituto Mexicano del Seguro Social
https://read.qxmd.com/read/36533358/-clinical-analysis-of-5-cases-of-dermatomyositis-complicated-with-macrophage-activation-syndrome
#38
JOURNAL ARTICLE
X Y Xing, J X Zhang, F Y Zhu, Y F Wang, X Y Zhou, Y H Li
To investigate the clinical and immunological features of dermatomyositis (DM) complicated with macrophage activation syndrome (MAS). The demographic and clinical characteristics of five patients diagnosed with DM complicated with MAS hospitalized in the Department of Rheumatology and Immunology, Peking University People ' s Hospital from 2011 to 2021 were collected. The results of clinical manifestations, laboratory tests, immunological features, treatments and prognosis were analyzed and summarized. In this study, five female patients in Peking University People's Hospital with an average age of 63...
December 18, 2022: Beijing da Xue Xue Bao. Yi Xue Ban, Journal of Peking University. Health Sciences
https://read.qxmd.com/read/36278969/juvenile-dermatomyositis-associated-with-autoantibodies-to-small-ubiquitin-like-modifier-activating-enzyme-a-report-of-4-cases-from-north-india-and-a-review-of-literature
#39
REVIEW
Pandiarajan Vignesh, Prabal Barman, Suprit Basu, Sanjib Mondal, Bhoomika Ishran, Rajni Kumrah, Aditya Dod, Ravinder Garg, Amit Rawat, Surjit Singh
BACKGROUND: Juvenile dermatomyositis (JDM) is the commonest inflammatory myositis in children. The clinical phenotype is often characterized by the presence of myositis-specific antibodies (MSA). Antibodies to small ubiquitin-like modifier activating enzyme (SAE) are amongst the rarest MSA reported in children. MATERIALS AND METHODS: A review of medical records of all patients diagnosed to have JDM during the period January 1992-April 2022 in our institute was done...
February 2023: Immunologic Research
https://read.qxmd.com/read/36211445/prediction-model-for-the-pretreatment-evaluation-of-mortality-risk-in-anti-melanoma-differentiation-associated-gene-5-antibody-positive-dermatomyositis-with-interstitial-lung-disease
#40
JOURNAL ARTICLE
Xianhua Gui, Wangzhong Li, Yanzhe Yu, Tingting Zhao, Ziyi Jin, Kaifang Meng, Rujia Wang, Shenyun Shi, Min Yu, Miao Ma, Lulu Chen, Wei Luan, Xiaoyan Xin, Yuying Qiu, Xiaohua Qiu, Yingwei Zhang, Min Cao, Mengshu Cao, Jinghong Dai, Hourong Cai, Mei Huang, Yonglong Xiao
BACKGROUND: Anti-melanoma differentiation-associated gene 5 antibody-positive dermatomyositis with interstitial lung disease (anti-MDA5 DM-ILD) is a disease with high mortality. We sought to develop an effective and convenient prediction tool to estimate mortality risk in patients with anti-MDA5 DM-ILD and inform clinical decision-making early. METHODS: This prognostic study included Asian patients with anti-MDA5 DM-ILD hospitalized at the Nanjing Drum Hospital from December 2016 to December 2020...
2022: Frontiers in Immunology
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