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Chilling requirement

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https://www.readbyqxmd.com/read/27917391/adrift-in-the-gray-zone-irb-perspectives-on-research-in-the-learning-health-system
#1
Sandra Soo-Jin Lee, Maureen Kelley, Mildred K Cho, Stephanie Alessi Kraft, Cyan James, Melissa Constantine, Adrienne N Meyer, Douglas Diekema, Alexander M Capron, Benjamin S Wilfond, David Magnus
BACKGROUND: Human subjects protection in healthcare contexts rests on the premise that a principled boundary distinguishes clinical research and clinical practice. However, growing use of evidence-based clinical practices by health systems makes it increasingly difficult to disentangle research from a wide range of clinical activities that are sometimes called "research on medical practice" (ROMP), including quality improvement activities and comparative effectiveness research. The recent growth of ROMP activities has created an ethical and regulatory gray zone with significant implications for the oversight of human subjects research...
2016: AJOB Empirical Bioethics
https://www.readbyqxmd.com/read/27891134/cucumber-cucumis-sativus-l-nitric-oxide-synthase-associated-gene1-csnoa1-plays-a-role-in-chilling-stress
#2
Xingwang Liu, Bin Liu, Shudan Xue, Yanlinq Cai, Wenzhu Qi, Chen Jian, Shuo Xu, Ting Wang, Huazhong Ren
Nitric oxide (NO) is a gaseous signaling molecule in plants, transducing information as a result of exposure to low temperatures. However, the underlying molecular mechanism linking NO with chilling stress is not well understood. Here, we functionally characterized the cucumber (Cucumis sativus L.) nitric oxide synthase-associated gene, NITRIC OXIDE ASSOCIATED 1 (CsNOA1). Expression analysis of CsNOA1, using quantitative real-time PCR, in situ hybridization, and a promoter::β-glucuronidase (GUS) reporter assay, revealed that it is expressed mainly in the root and shoot apical meristem (SAM), and that expression is up-regulated by low temperatures...
2016: Frontiers in Plant Science
https://www.readbyqxmd.com/read/27862395/the-nuclear-and-developmental-competence-of-cumulus-oocyte-complexes-is-enhanced-by-three-dimensional-coculture-with-conspecific-denuded-oocytes-during-in-vitro-maturation-in-the-domestic-cat-model
#3
M G Morselli, G C Luvoni, P Comizzoli
The objective of the study was to assess the efficacy of coculture with conspecific cumulus-denuded oocytes (CDOs) during in vitro maturation in a three-dimensional system of barium alginate microcapsules on the in vitro embryo development of domestic cat cumulus-oocyte complexes (COCs). In Experiment I, COCs were cocultured with conspecific CDOs or cultured separately in a 3D system for 24 hr of in vitro maturation, before assessing the meiotic progression. In Experiment II, the in vitro fertilization of COCs and CDOs was carried out with chilled epididymal spermatozoa and the presumptive zygotes were cultured in vitro separately for 7 days in 3D microcapsules before assesment of embryonic development...
November 15, 2016: Reproduction in Domestic Animals, Zuchthygiene
https://www.readbyqxmd.com/read/27802854/syphilis-an-atypical-case-of-sepsis-and-multiple-anogenital-lesions-in-secondary-syphilis
#4
Nichole Smith, Sonu Dhillon, John G Cotter, Zohair Ahmed
The incidence of syphilis has historically been cyclical in nature, often in relation to the rise and fall of public health initiatives directed toward eradication along with social attitudes toward sexual practices. The incidence of syphilis has increased by 15% in the last 6 years in the United States, with similar increases worldwide. Herein, we present an atypical case of syphilis presenting with severe septic shock and multiple anogenital lesions in an immunocompetent host. A 22-year-old male with no significant past medical history presented with fevers, chills, sore throat, diaphoresis, and diarrhea...
2016: Journal of Community Hospital Internal Medicine Perspectives
https://www.readbyqxmd.com/read/27791156/chilling-induced-tomato-flavor-loss-is-associated-with-altered-volatile-synthesis-and-transient-changes-in-dna-methylation
#5
Bo Zhang, Denise M Tieman, Chen Jiao, Yimin Xu, Kunsong Chen, Zhangjun Fe, James J Giovannoni, Harry J Klee
Commercial tomatoes are widely perceived by consumers as lacking flavor. A major part of that problem is a postharvest handling system that chills fruit. Low-temperature storage is widely used to slow ripening and reduce decay. However, chilling results in loss of flavor. Flavor-associated volatiles are sensitive to temperatures below 12 °C, and their loss greatly reduces flavor quality. Here, we provide a comprehensive view of the effects of chilling on flavor and volatiles associated with consumer liking...
November 1, 2016: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/27774325/acute-hemolysis-with-renal-failure-due-to-clostridium-bacteremia-in-a-patient-with-aml
#6
R M Medrano-Juarez, D Sotello, M A Orellana-Barrios, L D'Cuhna, J D Payne, K Nugent
We present a case of acute hemolytic anemia, renal failure, and Clostridium perfringens bacteremia in a patient with acute myelogenous leukemia. The high fatality of C. perfringens bacteremia requires that clinicians recognize and rapidly treat patients at risk for this infection. Although other hemolytic processes are in the differential diagnosis of these events, the presence of high fever, chills, and rapidly positive blood cultures may help narrow the diagnosis. Most cases of C. perfringens bacteremia have a concomitant coinfection, which makes broad spectrum empiric therapy essential...
2016: Case Reports in Infectious Diseases
https://www.readbyqxmd.com/read/27764220/epidemiology-and-clinical-presentations-of-respiratory-syncytial-virus-subgroups-a-and-b-detected-with-multiplex-real-time-pcr
#7
Wenkuan Liu, Dehui Chen, Weiping Tan, Duo Xu, Shuyan Qiu, Zhiqi Zeng, Xiao Li, Rong Zhou
Respiratory syncytial virus (RSV) is one of the most important pathogenic infections of children and requires in-depth research worldwide, and especially in developing countries. We used a novel multiplex real-time PCR to test 5483 patients (≤ 14 years old) hospitalized with respiratory illness in Guangzhou, China, over a 3-year period. Of these patients, 729 were positive for RSV-A (51.2%, 373/729) or RSV-B (48.8%, 356/729), but none was infected with both viruses. Two seasonal peaks in total RSV were detected at the changes from winter to spring and from summer to autumn...
2016: PloS One
https://www.readbyqxmd.com/read/27756575/identification-of-methylosome-components-as-negative-regulators-of-plant-immunity-using-chemical-genetics
#8
Shuai Huang, Aruna Balgi, Yaping Pan, Meng Li, Xiaoran Zhang, Lilin Du, Ming Zhou, Michel Roberge, Xin Li
Nucleotide-binding leucine-rich repeat (NLR) proteins serve as immune receptors in both plants and animals. To identify components required for NLR-mediated immunity, we designed and carried out a chemical genetics screen to search for small molecules that can alter immune responses in Arabidopsis thaliana. From 13 600 compounds, we identified Ro 8-4304 that was able to specifically suppress the severe autoimmune phenotypes of chs3-2D (chilling sensitive 3, 2D), including the arrested growth morphology and heightened PR (Pathogenesis Related) gene expression...
December 5, 2016: Molecular Plant
https://www.readbyqxmd.com/read/27752374/empyema-secondary-to-actinomyces-meyeri-treated-successfully-with-ceftriaxone-followed-by-doxycycline
#9
Etienne Paris, Tonio Piscopo, Karen Cassar
Actinomycosis is a relatively rare infection caused by Gram-positive bacteria. We present the case of a 54-year-old, previously healthy, male patient with a history of severe penicillin allergy who developed severe pneumonia and empyema caused by Actinomyces meyeri. Presenting symptoms included productive cough, right upper quadrant pain, and chills and rigors. He required drainage of the empyema via tube and prolonged antibiotic treatment with intravenous ceftriaxone for 2 weeks followed by oral doxycycline for 6 months...
2016: Case Reports in Infectious Diseases
https://www.readbyqxmd.com/read/27716066/maize-plants-can-enter-a-standby-mode-to-cope-with-chilling-stress
#10
Laëtitia Riva-Roveda, Brigitte Escale, Catherine Giauffret, Claire Périlleux
BACKGROUND: European Flint maize inbred lines are used as a source of adaptation to cold in most breeding programs in Northern Europe. A deep understanding of their adaptation strategy could thus provide valuable clues for further improvement, which is required in the current context of climate change. We therefore compared six inbreds and two derived Flint x Dent hybrids for their response to one-week at low temperature (10 °C day/7 or 4 °C night) during steady-state vegetative growth...
October 4, 2016: BMC Plant Biology
https://www.readbyqxmd.com/read/27699788/temperature-dependent-autoimmunity-mediated-by-chs1-requires-its-neighboring-tnl-gene-soc3
#11
Yao Zhang, Yuancong Wang, Jingyan Liu, Yanglin Ding, Shanshan Wang, Xiaoyan Zhang, Yule Liu, Shuhua Yang
Toll/interleukin receptor (TIR)-nucleotide binding site (NB)-type (TN) proteins are encoded by a family of 21 genes in the Arabidopsis genome. Previous studies have shown that a mutation in the TN gene CHS1 activates the activation of defense responses at low temperatures. However, the underlying molecular mechanism remains unknown. To genetically dissect chs1-mediated signaling, we isolated genetic suppressors of chs1-2 (soc). Several independent soc mutants carried mutations in the same TIR-NB-leucine-rich repeat (LRR) (TNL)-encoding gene SOC3, which is adjacent to CHS1 on chromosome 1...
October 4, 2016: New Phytologist
https://www.readbyqxmd.com/read/27697786/axillary-buds-are-dwarfed-shoots-that-tightly-regulate-ga-pathway-and-ga-inducible-1-3-%C3%AE-glucanase-genes-during-branching-in-hybrid-aspen
#12
Päivi L H Rinne, Laju K Paul, Jorma Vahala, Jaakko Kangasjärvi, Christiaan van der Schoot
Axillary buds (AXBs) of hybrid aspen (Populus tremula×P. tremuloides) contain a developing dwarfed shoot that becomes para-dormant at the bud maturation point. Para-dormant AXBs can grow out after stem decapitation, while dormant AXBs pre-require long-term chilling to release them from dormancy. The latter is mediated by gibberellin (GA)-regulated 1,3-β-glucanases, but it is unknown if GA is also important in the development, activation, and outgrowth of para-dormant AXBs. The present data show that para-dormant AXBs up-regulate GA receptor genes during their maturation, but curtail GA biosynthesis by down-regulating the rate-limiting GIBBERELLIN 3-OXIDASE2 (GA3ox2), which is characteristically expressed in the growing apex...
October 3, 2016: Journal of Experimental Botany
https://www.readbyqxmd.com/read/27687047/incidence-of-infusion-reactions-to-anti-neoplastic-agents-in-early-phase-clinical-trials-the-md-anderson-cancer-center-experience
#13
Manojkumar Bupathi, Joud Hajjar, Stacie Bean, Siqing Fu, David Hong, Daniel Karp, Bettzy Stephen, Kenneth Hess, Funda Meric-Bernstam, Aung Naing
Infusion reactions (IRs) to anti-neoplastic agents require prompt recognition and immediate treatment to avert significant complications. We conducted a retrospective review of the medical records of consecutive patients who received anti-neoplastic therapy in the outpatient treatment center of the Department of Investigational Cancer Therapeutics from January 1, 2013 to November 30, 2013. Of the 597 patients who received treatment, 9 (1.5 %) had IRs (all ≤ grade 2). The most common IRs observed on first occurrence were chills (n = 5), itching, rash, and facial flushing (n = 3 each)...
September 29, 2016: Investigational New Drugs
https://www.readbyqxmd.com/read/27634420/cryopreservation-of-indian-red-jungle-fowl-gallus-gallus-murghi-semen
#14
B A Rakha, M S Ansari, S Akhter, I Hussain, E Blesbois
The population of red jungle fowl is declining and needs special attention for its conservation with suitable approaches. For ex situ in vitro conservation of Indian red jungle fowl, establishment of semen cryobank is an appropriate option, for which an extender with adequate retrieval capacity for functional spermatozoa is required. Therefore, studies were designed to evaluate a wide range of extenders for cryopreservation of Indian red jungle fowl (Gallus gallus murghi) sperm to achieve maximal post-thawed semen quality and fertility...
September 6, 2016: Animal Reproduction Science
https://www.readbyqxmd.com/read/27514876/chilling-requirements-for-hatching-of-a-new-zealand-isolate-of-nematodirus-filicollis
#15
A-M B Oliver, W E Pomroy, S Ganesh, D M Leathwick
The eggs of some species of the parasitic nematode Nematodirus require a period of chilling before they can hatch; N. filicollis is one such species. This study investigated this requirement for chilling in a New Zealand strain of this species. Eggs of N. filicollis were extracted from lamb's faeces and incubated at 20°C to allow development to the third stage larvae within the egg. These eggs were then placed into tissue culture plates and incubated at: 2.7°C (±0.99), 3.6°C (±0.90), 4.7°C (±0.35), 6...
August 15, 2016: Veterinary Parasitology
https://www.readbyqxmd.com/read/27501791/transcriptome-analysis-of-seed-dormancy-after-rinsing-and-chilling-in-ornamental-peaches-prunus-persica-l-batsch
#16
Worarad Kanjana, Tomohiro Suzuki, Kazuo Ishii, Toshinori Kozaki, Masayuki Iigo, Kenji Yamane
BACKGROUND: Ornamental peaches cv. 'Yaguchi' (Prunus persica (L.) Batsch) can be propagated via seeds. The establishment of efficient seed treatments for early germination and seedling growth is required to shorten nursery and breeding periods. It is important, therefore, to identify potential candidate genes responsible for the effects of rinsing and chilling on seed germination. We hypothesized that longer rinsing combined with chilling of seeds can alter the genes expression in related to dormancy and then raise the germination rate in the peach...
2016: BMC Genomics
https://www.readbyqxmd.com/read/27474721/systematic-assessment-of-nonproteolytic-clostridium-botulinum-spores-for-heat-resistance
#17
Ewelina Wachnicka, Sandra C Stringer, Gary C Barker, Michael W Peck
UNLABELLED: Heat treatment is an important controlling factor that, in combination with other hurdles (e.g., pH, aw), is used to reduce numbers and prevent the growth of and associated neurotoxin formation by nonproteolytic C. botulinum in chilled foods. It is generally agreed that a heating process that reduces the spore concentration by a factor of 10(6) is an acceptable barrier in relation to this hazard. The purposes of the present study were to review the available data relating to heat resistance properties of nonproteolytic C...
October 1, 2016: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/27445351/energy-and-lipid-metabolism-during-direct-and-diapause-development-in-a-pierid-butterfly
#18
Philipp Lehmann, Peter Pruisscher, Diana Posledovich, Mikael Carlsson, Reijo Käkelä, Patrik Tang, Sören Nylin, Christopher W Wheat, Christer Wiklund, Karl Gotthard
Diapause is a fundamental component of the life cycle in the majority of insects living in environments characterized by strong seasonality. The present study addresses poorly understood associations and trade-offs between endogenous diapause duration, thermal sensitivity of development, energetic cost of development and cold tolerance. Diapause intensity, metabolic rate trajectories and lipid profiles of directly developing and diapausing animals were studied using pupae and adults of Pieris napi butterflies from a population in which endogenous diapause has been well studied...
October 1, 2016: Journal of Experimental Biology
https://www.readbyqxmd.com/read/27436087/public-awareness-of-malaria-in-the-middle-stage-of-national-malaria-elimination-programme-a-cross-sectional-survey-in-rural-areas-of-malaria-endemic-counties-china
#19
Shangfeng Tang, Lu Ji, Tao Hu, Ruoxi Wang, Hang Fu, Tian Shao, Chunyan Liu, Piaopiao Shao, Zhe He, Gang Li, Zhanchun Feng
BACKGROUND: Remarkable progress in the elimination of malaria has been achieved by the Chinese government in the past 5 years. However, imported cases have increased rapidly, and it is a critical threat to the national malaria elimination programme. This study aims to investigate the current status of the public awareness of malaria in the middle stage of the national malaria elimination progress. METHODS: A cross-sectional survey with multi-stage stratified randomized sampling was undertaken between June 2015 and March 2016...
2016: Malaria Journal
https://www.readbyqxmd.com/read/27351423/treatments-for-breast-engorgement-during-lactation
#20
REVIEW
Lindeka Mangesi, Irena Zakarija-Grkovic
BACKGROUND: Breast engorgement is a painful condition affecting large numbers of women in the early postpartum period. It may lead to premature weaning, cracked nipples, mastitis and breast abscess. Various forms of treatment for engorgement have been studied but so far little evidence has been found on an effective intervention. OBJECTIVES: This is an update of a systematic review first published by Snowden et al. in 2001 and subsequently published in 2010. The objective of this update is to seek new information on the best forms of treatment for breast engorgement in lactating women...
2016: Cochrane Database of Systematic Reviews
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