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Willis ekbom disease

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https://www.readbyqxmd.com/read/29734979/executive-and-visuospatial-dysfunction-in-patients-with-primary-restless-legs-syndrome-willis-ekbom-disease-study-of-a-chinese-population
#1
Gen Li, Huidong Tang, Jie Chen, Xuemei Qi, Shengdi Chen, Jianfang Ma
STUDY OBJECTIVES: The aim of the study was to investigate the cognitive function of patients with primary restless legs syndrome/Willis-Ekbom disease (RLS/WED) in a Chinese population. METHODS: A total of 40 patients with RLS/WED who were drug naïve and 40 controls, matched by age, sex, and educational level, were evaluated by cognitive function assessments, including the Chinese version of the Mini-Mental State Examination (MMSE-C), clock drawing test (CDT), Auditory Verbal Learning Test (AVLT), Rey-Osterrieth Complex Figure Test (CFT), and Stroop Color Word Test (SCWT)...
April 30, 2018: Journal of Clinical Sleep Medicine: JCSM: Official Publication of the American Academy of Sleep Medicine
https://www.readbyqxmd.com/read/29680437/treatment-of-restless-legs-syndrome-willis-ekbom-disease-with-the-non-selective-ent1-ent2-inhibitor-dipyridamole-testing-the-adenosine-hypothesis
#2
Diego Garcia-Borreguero, Xavier Guitart, Celia Garcia Malo, Irene Cano-Pumarega, Juan José Granizo, Sergi Ferré
OBJECTIVES: Recent animal models of restless legs syndrome (RLS) suggest that brain iron deficiency is associated with a hypoadenosinergic state, with downregulation of adenosine A1 receptors (A1R) in the striatum and cortex. We hypothesized that an increase in extracellular adenosine induced by inhibitors of adenosine transporters, such as the non-selective ENT1/ENT2 inhibitor dipyridamole, would result in an improvement in RLS symptoms. METHODS: In a prospective two-month open-label, non-placebo controlled clinical trial, 15 untreated idiopathic RLS patients began treatment with 100 mg dipyridamole (with uptitration to 400 mg if necessary)...
May 2018: Sleep Medicine
https://www.readbyqxmd.com/read/29680426/willis-ekbom-disease-restless-legs-syndrome-in-patients-with-opioid-withdrawal
#3
Ravi Gupta, Ramjan Ali, Rajat Ray
INTRODUCTION: Many patients with opioid use disorder report symptoms similar to restless legs syndrome (RLS) during withdrawal. However, whether these symptoms are true RLS, their predictors and effect of treatment with pregabalin are still unknown. METHOD: A total of 19 consecutive patients with opioid use disorder who were admitted for detoxification were included in this study after obtaining informed consent. Information regarding addiction was noted, and they were screened for RLS every morning and evening...
May 2018: Sleep Medicine
https://www.readbyqxmd.com/read/29602660/management-of-treatment-failure-in-restless-legs-syndrome-willis-ekbom-disease
#4
REVIEW
Diego Garcia-Borreguero, Irene Cano-Pumarega, Rafael Marulanda
Dopaminergic drugs have been widely used over the last decades for the treatment of restless legs syndrome (RLS)/Willis-Ekbom disease (WED). While the majority of studies show an initial improvement in symptoms, longer studies and clinical experience show that either treatment efficacy decreases with time, and/or augmentation develops: dopaminergic augmentation has been reported to be the main reason for treatment discontinuation and treatment failure in RLS/WED. The current review discusses the main reasons for treatment failure in RLS/WED and outlines the most recent expert-based strategies to prevent and manage it...
January 9, 2018: Sleep Medicine Reviews
https://www.readbyqxmd.com/read/29480463/use-of-%C3%AE-2%C3%AE-ligands-for-restless-legs-syndrome-willis-ekbom-disease
#5
REVIEW
Michele A Faulkner
Restless legs syndrome is a common neurological condition affecting a substantial portion of the population. It can be an idiopathic disorder, or one that is secondary to another cause. Given that the underlying pathophysiology of restless legs syndrome is not well understood, several drug classes have been studied for symptom control. While dopamine agonists have long been the mainstay of first-line treatment for restless legs syndrome, recently, the α2δ ligands have been increasingly used. These agents have proven both efficacious and safe in a number of clinical trials...
February 2018: CNS Drugs
https://www.readbyqxmd.com/read/29434568/restless-legs-syndrome-willis-ekbom-disease-is-prevalent-in-working-nurses-but-seems-not-to-be-associated-with-shift-work-schedules
#6
Siri Waage, Ståle Pallesen, Bente Elisabeth Moen, Bjørn Bjorvatn
Insomnia and excessive sleepiness are among the most commonly reported sleep problems related to shift work. Sleep-related movement disorders have, however, received far less attention in relation to such work schedules. The objective of this study was to investigate the association between different shift work schedules and the prevalence of Restless legs syndrome/Willis-Ekbom disease (RLS/WED) in a large sample of Norwegian nurses. Our hypothesis was that shift working nurses would report higher prevalence of RLS/WED compared to day workers...
2018: Frontiers in Neurology
https://www.readbyqxmd.com/read/29425576/evidence-based-and-consensus-clinical-practice-guidelines-for-the-iron-treatment-of-restless-legs-syndrome-willis-ekbom-disease-in-adults-and-children-an-irlssg-task-force-report
#7
Richard P Allen, Daniel L Picchietti, Michael Auerbach, Yong Won Cho, James R Connor, Christopher J Earley, Diego Garcia-Borreguero, Suresh Kotagal, Mauro Manconi, William Ondo, Jan Ulfberg, John W Winkelman
BACKGROUND: Brain iron deficiency has been implicated in the pathophysiology of RLS, and current RLS treatment guidelines recommend iron treatment when peripheral iron levels are low. In order to assess the evidence on the oral and intravenous (IV) iron treatment of RLS and periodic limb movement disorder (PLMD) in adults and children, the International Restless Legs Syndrome Study Group (IRLSSG) formed a task force to review these studies and provide evidence-based and consensus guidelines for the iron treatment of RLS in adults, and RLS and PLMD in children...
January 2018: Sleep Medicine
https://www.readbyqxmd.com/read/29408974/the-impact-of-sleep-disorders-on-driving-safety-findings-from-the-second-strategic-highway-research-program-naturalistic-driving-study
#8
Shu-Yuan Liu, Miguel A Perez, Nathan Lau
Study Objectives: This study investigated the association between driving safety and seven sleep disorders amongst 3541 participants of the Second Strategic Highway Research Program (SHRP 2) naturalistic driving study. Methods: SHRP 2 collected naturalistic driving data from participants between 16 and 98 years old by instrumenting participants' vehicles. The analyses used logistic regression to determine the likelihood of crash or near-crash involvement, Poisson log-linear regression to assess crash or near-crash rate, and ordinal logistic regression to assess driver maneuver appropriateness and crash or near-crash severity...
April 1, 2018: Sleep
https://www.readbyqxmd.com/read/28869939/survival-of-dialysis-patients-with-restless-legs-syndrome-a-15-year-follow-up-study
#9
Simone Baiardi, Susanna Mondini, Alessandro Baldi Antognini, Antonio Santoro, Fabio Cirignotta
BACKGROUND: Restless legs syndrome, also known as Willis/Ekbom disease (RLS/WED), is a sleep-related, sensorimotor disorder with a high prevalence among end-stage renal disease (ESRD) patients undergoing haemodialysis (HD) (about 15-40%). Whether RLS/WED in uremic patients influences cardiovascular morbidity and mortality remains a matter of controversy. The aim of this study was to evaluate the relationship of RLS/WED and mortality in a population of chronically dialyzed patients. METHOD: In 1996, we studied 128 patients with ESRD undergoing HD; 47 subjects (36...
2017: American Journal of Nephrology
https://www.readbyqxmd.com/read/28818004/identification-and-treatment-of-augmentation-in-patients-with-restless-legs-syndrome-practical-recommendations
#10
REVIEW
James Geyer, Richard Bogan
Restless legs syndrome (RLS) is a chronic disorder causing clinically significant discomfort to approximately 3% of adults. Although RLS was first identified centuries ago, our understanding of this disorder, its causes, and its treatments is still evolving. In particular, our knowledge of the potential negative effects of RLS treatments, including dopaminergic augmentation, continues to expand. Augmentation, which refers to a paradoxical treatment-related increase in RLS symptoms, has been associated with all three dopamine agonists approved for the treatment of RLS - rotigotine, pramipexole, and ropinirole...
September 2017: Postgraduate Medicine
https://www.readbyqxmd.com/read/28682991/the-effect-of-cold-dialysis-in-motor-and-sensory-symptoms-of-rls-wed-occurring-during-hemodialysis-a-double-blind-study
#11
Giorgos K Sakkas, Evaggelia Tsaknaki, Clara S Rosa, Christoforos D Giannaki, Argyro A Krase, Eleftherios Lavdas, Georgios M Hadjigeorgiou, Ioannis Stefanidis, Christina Karatzaferi
Restless legs syndrome/Willis-Ekbom disease (RLS/WED) is a common sensorimotory disorder affecting almost 30% of hemodialysis (HD) patients. RLS/WED induces discomfort during rest hours, and its symptoms have also been observed during HD sessions. Anecdotal reports suggest that cooling the dialysate solution during dialysis could help patients overcome those symptoms and improve restlessness. The aim of this double-blind study was to assess whether a reduction of the dialysate temperature by 1°C could reduce motor and sensory symptoms of RLS/WED occurring during HD...
January 2018: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
https://www.readbyqxmd.com/read/28619185/high-prevalence-of-restless-legs-syndrome-willis-ekbom-disease-rls-wed-among-people-living-at-high-altitude-in-the-indian-himalaya
#12
Ravi Gupta, Jan Ulfberg, Richard P Allen, Deepak Goel
BACKGROUND: At high altitude, prevalence of restless legs syndrome has been found to be greater than expected in small population-based studies, which did not use validated tools for identification of RLS. However, it is not known as to whether this increased prevalence is associated with altitude or increased risk factors for RLS in these populations or errors in identification of RLS. METHOD: This population based, door-to-door study was conducted at low altitude (400 m above sea level) and high altitudes (1900-2000 m and 3200 m above sea level) using random stratified sampling in Himalayan and sub-Himalayan region of India...
July 2017: Sleep Medicine
https://www.readbyqxmd.com/read/28435634/treatment-of-restless-legs-syndrome-willis-ekbom-disease-with-selenium
#13
Jan Ulfberg, Romana Stehlik, Ulrike Mitchell
No abstract text is available yet for this article.
October 7, 2016: Iranian Journal of Neurology
https://www.readbyqxmd.com/read/28425083/restless-legs-syndrome-willis-ekbom-disease-prevalence-in-beta-thalassemia-patients
#14
Euthimia Dimitriadou, Christoforos D Giannaki, Maria Tsekoura, Ioannis Stefanidis, Georgios M Hadjigeorgiou, Eleftherios Lavdas, Christina Karatzaferi, Giorgos K Sakkas
PURPOSE: Both beta thalassemia and restless legs syndrome (RLS) patients share some common pathophysiological characteristics related to iron handling. In the present study, the aim was to explore the prevalence of RLS as well as to explore potential association between the syndrome and various quality of life-related parameters in a sample of beta thalassemia patients. METHODS: One hundred fourteen (age 40 ± 11 yr, 59 M/55F) beta thalassemia patients participated in this cross-sectional descriptive study...
March 2018: Sleep & Breathing, Schlaf & Atmung
https://www.readbyqxmd.com/read/28366342/pharmacokinetics-of-rotigotine-transdermal-system-in-adolescents-with-idiopathic-restless-legs-syndrome-willis-ekbom-disease
#15
Jan-Peer Elshoff, John Hudson, Daniel L Picchietti, Keith Ridel, Arthur S Walters, Kimberly Doggett, Kimberly Moran, Marga Oortgiesen, Francisco Ramirez, Erwin Schollmayer
OBJECTIVE: To investigate the pharmacokinetics (PK) of rotigotine transdermal system in adolescents with moderate-to-severe idiopathic restless legs syndrome (RLS). METHODS: This multicenter, open-label, dose-escalation study enrolled patients ≥13 to <18 years of age. Rotigotine transdermal patches were applied daily and up-titrated weekly: 0.5, 1, 2, 3 mg/24 h. Blood samples were collected on the final day of each dose step. Primary PK variables were the apparent total body clearance (CL/f; L/h) and volume of distribution at steady state (VSS /f; L) of unconjugated rotigotine for each dose step, calculated for the PK per-protocol set (PKPPS)...
April 2017: Sleep Medicine
https://www.readbyqxmd.com/read/28332327/restless-legs-syndrome-willis-ekbom-disease-in-type-2-diabetes-as-the-initial-manifestation-of-parkinson-s-disease-and-major-cardiovascular-disease
#16
Chun-Hsien Hsu, Shu-Man Yu, Shu Chuen Lau, Yen-Lin Chen, Dee Pei, I-Chao Liu
No abstract text is available yet for this article.
November 2017: Psychogeriatrics: the Official Journal of the Japanese Psychogeriatric Society
https://www.readbyqxmd.com/read/28320166/the-duration-of-the-cortical-silent-period-is-not-abnormal-in-restless-legs-syndrome-willis-ekbom-disease
#17
Joselisa Péres Queiroz de Paiva, Samir Câmara Magalhães, Gilmar Fernandes do Prado, Alan Luiz Eckeli, Alain Kaelin-Lang, Adriana Bastos Conforto
OBJECTIVE: To compare the duration of the cortical silent period (CSP) measured in a hand muscle in subjects with primary Restless Legs Syndrome (RLS/WED) and controls, using four different methods of analysis. METHODS: The CSP to transcranial magnetic stimulation of the dominant motor cortex was assessed in the abductor digiti minimi of 33 subjects with RLS/WED and 24 controls. CSP duration was measured by an automated and three visually-guided methods. RESULTS: There were significant differences between absolute values of CSP duration according to the method of analysis...
April 15, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/28283108/higher-prevalence-of-restless-legs-syndrome-willis-ekbom-disease-in-multiple-sclerosis-patients-is-related-to-spinal-cord-lesions
#18
M Minár, D Petrleničová, P Valkovič
BACKGROUND: Multiple sclerosis (MS) is connected with higher prevalence of secondary restless legs syndrome/Willis-Ekbom disease (RLS/WED). Aim of this study was to determine risk factor for developing symptoms of RLS in MS patients. METHODS: In cross-sectional study we examined 200 random MS patients. After obtaining informed consents, patients undervent a structured interview based on RLS and MS symptoms and characteristics, demographic, and health-related data...
February 2017: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/28242627/new-concepts-in-the-management-of-restless-legs-syndrome
#19
REVIEW
Diego Garcia-Borreguero, Irene Cano-Pumarega
Restless legs syndrome (RLS), also known as Willis-Ekbom disease (WED) is a neurological condition with an overall prevalence in adults of 5-10% in Europe and North America. It is characterised by strong feelings of restlessness and distressing paraesthesia-like sensations in the lower legs, particularly when at rest. The symptoms vary considerably in severity and frequency. RLS/WED has a variable clinical expression influenced by genetic, environmental, and medical factors. Research into the pathophysiology of RLS/WED has found that various genetic markers and existing dysfunctions in dopaminergic mechanisms and iron mechanisms play a central role...
February 27, 2017: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/28215250/prevalence-and-quality-of-life-and-sleep-in-children-and-adolescents-with-restless-legs-syndrome-willis-ekbom-disease
#20
Heidi Haueisen Sander, Alan Luiz Eckeli, Afonso Diniz Costa Passos, Leila Azevedo, Lucila Bizari Fernandes do Prado, Regina Maria França Fernandes
OBJECTIVE: To estimate the prevalence of restless legs syndrome/Willis-Ekbom disease (RLS/WED) and its impact on sleep and quality of life in children and adolescents. METHODS: This was a cross-sectional study conducted in the Municipality of Cássia dos Coqueiros, Brazil. Participants included 383 children and adolescents 5-17 years of age. A comparison group was randomly matched by gender and age with the RLS/WED-affected individuals, pairing one by one. RESULTS: Interviews were conducted for 383 individuals by a neurologist experienced in sleep medicine...
February 2017: Sleep Medicine
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