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Willis ekbom disease

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https://www.readbyqxmd.com/read/27894926/special-issue-advances-in-scientific-understanding-of-the-restless-legs-syndrome-rls-aka-willis-ekbom-disease-wed-introduction-towards-a-better-understanding-of-the-science-of-rls-wed
#1
EDITORIAL
Diego Garcia Borreguero, Juliane Winkelman, Richard P Allen
No abstract text is available yet for this article.
October 28, 2016: Sleep Medicine
https://www.readbyqxmd.com/read/27692278/default-mode-network-disturbances-in-restless-legs-syndrome-willis-ekbom-disease
#2
Jeonghun Ku, Yeong Seon Lee, HyukWon Chang, Christopher J Earley, Richard P Allen, Yong Won Cho
BACKGROUND: The unusual sensations of restless legs syndrome/Willis-Ekbom disease (RLS/WED) are induced by rest or a low arousal state with a circadian variation in the threshold for induction. It has been suggested that the emergence of RLS/WED symptoms relates to abnormal brain functions dealing with internally generated stimuli. The purpose of this study was to investigate the changes in the default mode network (DMN) in RLS/WED subjects. METHODS: Sixteen drug-naïve, idiopathic, RLS/WED subjects, and 16 age-matched and gender-matched healthy subjects were scanned in an asymptomatic resting state...
July 2016: Sleep Medicine
https://www.readbyqxmd.com/read/27662970/association-between-the-neutrophil-to-lymphocyte-ratio-a-new-marker-of-systemic-inflammation-and-restless-legs-syndrome
#3
Ceyhun Varım, Bilgehan Atılgan Acar, Mehmet Sevki Uyanık, Turkan Acar, Neslihan Alagoz, Ahmet Nalbant, Tezcan Kaya, Hasan Ergenc
INTRODUCTION: Restless legs syndrome (RLS), also known as Willis-Ekbom disease, is characterised by abnormal sensations in the legs as well as dysaesthesia. Although the aetiology of RLS has not yet been determined, it may be associated with systemic inflammation. The neutrophil-to-lymphocyte ratio (NLR) is a new and simple marker indicating systemic inflammation. The present study aimed to investigate the relationship between systemic inflammation and RLS through the use of the NLR. METHODS: A total of 75 newly diagnosed patients with RLS and 56 healthy control subjects were included in the study...
September 2016: Singapore Medical Journal
https://www.readbyqxmd.com/read/27512466/restless-leg-syndrome-in-pregnancy
#4
REVIEW
Aarti Grover, Courtney Clark-Bilodeau, Carolyn M D'Ambrosio
Restless leg syndrome, more recently renamed Willis-Ekbom disease, is a condition that disrupts sleep and occurs more frequently in the pregnant population. We present a 39-year-old woman with restless legs syndrome in the third trimester and discuss the epidemiology, pathophysiology and therapeutic options in the pregnant population while highlighting the challenges posed by the lack of safety data of approved drugs.
September 2015: Obstetric Medicine
https://www.readbyqxmd.com/read/27448465/guidelines-for-the-first-line-treatment-of-restless-legs-syndrome-willis-ekbom-disease-prevention-and-treatment-of-dopaminergic-augmentation-a-combined-task-force-of-the-irlssg-eurlssg-and-the-rls-foundation
#5
Diego Garcia-Borreguero, Michael H Silber, John W Winkelman, Birgit Högl, Jacquelyn Bainbridge, Mark Buchfuhrer, Georgios Hadjigeorgiou, Yuichi Inoue, Mauro Manconi, Wolfgang Oertel, William Ondo, Juliane Winkelmann, Richard P Allen
A Task Force was established by the International Restless Legs Syndrome Study Group (IRLSSG) in conjunction with the European Restless Legs Syndrome Study Group (EURLSSG) and the RLS Foundation (RLS-F) to develop evidence-based and consensus-based recommendations for the prevention and treatment of long-term pharmacologic treatment of dopaminergic-induced augmentation in restless legs syndrome/Willis-Ekbom disease (RLS/WED). The Task Force made the following prevention and treatment recommendations: As a means to prevent augmentation, medications such as α2δ ligands may be considered for initial RLS/WED treatment; these drugs are effective and have little risk of augmentation...
May 2016: Sleep Medicine
https://www.readbyqxmd.com/read/27424684/prevalence-and-correlates-of-willis-ekbom-s-disease-restless-legs-syndrome-in-patients-undergoing-hemodialysis
#6
Nitik Bathla, Sohaib Ahmad, Ravi Gupta, Shahbaj Ahmad
Willis-Ekbom's disease/restless legs syndrome (WED/RLS) has been described in subjects undergoing hemodialysis (HD). Different studies have reported varying prevalence rates and different factors associated with this condition; however, the results are inconsistent. Thus, this study was conducted to assess the prevalence of WED/RLS in patients undergoing HD. Another aim of the study was to identify if any comorbidities or biochemical factors were associated with this condition. A total of 194 adult patients undergoing maintenance HD were included in this study...
July 2016: Saudi Journal of Kidney Diseases and Transplantation
https://www.readbyqxmd.com/read/27318235/rating-of-daytime-and-nighttime-symptoms-in-rls-validation-of-the-rls-6-scale-of-restless-legs-syndrome-willis-ekbom-disease
#7
Ralf Kohnen, Pablo Martinez-Martin, Heike Benes, Claudia Trenkwalder, Birgit Högl, Elmar Dunkl, Arthur S Walters
BACKGROUND: The International Restless Legs Scale (IRLS) is the most widely used of the scales rating the severity of restless legs syndrome/Willis-Ekbom disease (RLS/WED). It has been well validated and is the primary end point for most of the therapeutic and nontherapeutic studies of RLS/WED. It has excellent psychometric properties, although it does not capture the severity of RLS under a wide variety of circumstances and times of day. Moreover, the IRLS has a large placebo effect...
April 2016: Sleep Medicine
https://www.readbyqxmd.com/read/27292821/-emplotted-narratives-and-structured-behavioral-observations-supporting-the-diagnosis-of-willis-ekbom-disease-restless-legs-syndrome-in-children-with-neurodevelopmental-conditions
#8
Osman S Ipsiroglu, Nadia Beyzaei, Mai Berger, Alexandra L Wagner, Sophia Dhalla, Jennifer Garden, Sylvia Stockler
BACKGROUND: Willis-Ekbom disease/restless legs syndrome (WED/RLS) seems to be a frequent cause of intractable chronic insomnia (ICI) but is under-recognized in children/adolescents with neurodevelopmental conditions (NDCs), as many patients do not have the ability to express the underlying "urge-to-move". In light of this, we aim to develop a protocol for behavioral observations supporting the diagnosis of WED/RLS. METHODS: We investigated 26 pediatric patients (age 1-16 years, median 8) with NDCs, ICI and evidence of familial WED/RLS employing (1) "emplotted narratives" for description of the various "urge-to-move" presentations and (2) self-description and "behavioral observations" during a "suggested clinical immobilization test" (SCIT)...
June 13, 2016: CNS Neuroscience & Therapeutics
https://www.readbyqxmd.com/read/27240804/to-what-extent-and-why-are-copd-and-willis-ekbom-disease-associated
#9
Tugba Mandal, Şenay Aydın, Dilek Kanmaz, Ahmet Levent Karasulu, Gülfidan Aras, Esin Tuncay
AIM: Willis-Ekbom disease (RLS/WED) is common in chronic obstructive pulmonary disease (COPD). Patients with RLS/WED have poorer quality of sleep and more fatigue and depressive symptoms. The prevalence of RLS/WED in patients with COPD has been reported to vary between 29.1 and 36.8 %. However, during exacerbation, the prevalence can increase up to 54 %. These rates are higher than those seen in general population. We have not enough knowledge regarding the association between RLS and COPD...
September 2016: Sleep & Breathing, Schlaf & Atmung
https://www.readbyqxmd.com/read/27224246/clinical-pharmacology-and-efficacy-of-rotigotine-neupro%C3%A2-patch-in-the-treatment-of-restless-leg-syndrome
#10
Luigi Ferini-Strambi, Sara Marelli, Andrea Galbiati
INTRODUCTION: Restless legs syndrome/Willis Ekbom disease (RLS/WED) is a sensorimotor disorder characterized by unpleasant sensations in the legs accompanied by an urge to move them, that typically occurs and tend to worsen in the evening/night or during period of inactivity. Standard medications for RLS/WED are dopamine agonists and calcium channel α-2-δ ligands. The clinical spectrum of RLS/WED is very broad, ranging from individuals suffering from the disease during limited periods up to those severely affected, with daily symptoms...
August 2016: Expert Opinion on Drug Metabolism & Toxicology
https://www.readbyqxmd.com/read/27191240/what-s-in-a-name-problems-facts-and-controversies-regarding-neurological-eponyms
#11
Hélio A G Teive, Plínio M G Lima, Francisco M B Germiniani, Renato P Munhoz
The use of eponyms in neurology remains controversial, and important questions have been raised about their appropriateness. Different approaches have been taken, with some eponyms being excluded, others replaced, and new ones being created. An example is Hallervorden-Spatz syndrome, which has been replaced by neurodegeneration with brain iron accuulatium (NBIA). Amiothoplic lateral sclerosys (ALS), for which the eponym is Charcot's disease, has been replaced in the USA by Lou Gehrig's disease. Guillain-Barré syndrome (GBS) is an eponym that is still the subject of controversy, and various different names are associated with it...
May 2016: Arquivos de Neuro-psiquiatria
https://www.readbyqxmd.com/read/27079737/targinact-for-restless-legs-syndrome
#12
(no author information available yet)
Idiopathic restless legs syndrome (RLS)--also known as Willis-Ekbom disease--is a neurological condition characterised by an overwhelming urge to move the legs, occurring during rest or inactivity, especially at night. Symptoms are highly variable in frequency and severity, and can affect sleep and quality of life. First-line management includes addressing precipitating or aggravating factors and providing explanation, reassurance and advice on self-help strategies. Drug therapy (e.g. a dopamine agonist) is used for patients with more severe symptoms...
April 2016: Drug and Therapeutics Bulletin
https://www.readbyqxmd.com/read/26902775/restless-legs-syndrome-willis-ekbom-disease-and-periodic-limb-movements-a-comprehensive-review-of-epidemiology-pathophysiology-diagnosis-and-treatment-considerations
#13
Dyveke P Pratt
Restless legs syndrome (RLS) or Willis-Ekbom Disease is a common, but frequently under- recognized and misdiagnosed condition seen in many subspecialty practices including neurology, sleep medicine, primary care and rheumatology. Periodic limb movements are a frequent co-morbid diagnosis in RLS. Despite prior beliefs that the condition was "benign", it has been demonstrated to have a considerable impact on sufferers quality of life, physically and psychologically, as well as socially. This chapter is meant as a comprehensive review of RLS encompassing epidemiology, pathophysiology, diagnosis, and treatment considerations...
2016: Current Rheumatology Reviews
https://www.readbyqxmd.com/read/26874840/treatment-options-in-intractable-restless-legs-syndrome-willis-ekbom-disease-rls-wed
#14
Fabrizio Rinaldi, Andrea Galbiati, Sara Marelli, Luigi Ferini Strambi, Marco Zucconi
Restless Legs Syndrome/Willis-Ekbom Disease (RLS/WED) is a common condition characterized by an irresistible urge to move the legs, concomitant with an unpleasant sensation in the lower limbs, which is typically relieved by movement. Symptoms occur predominantly at rest and prevail in the afternoon or evening. Treatment of patients with RLS/WED is indicated for those patients who suffer from clinically relevant symptoms. The management of mild forms of RLS/WED is mainly based on dopamine agonists (DA) therapy (including pramipexole and ropinirole) and α-2-δ calcium-channel ligand...
February 2016: Current Treatment Options in Neurology
https://www.readbyqxmd.com/read/26742672/restless-legs-syndrome-willis-ekbom-disease-new-diagnostic-criteria-according-to-different-nosology
#15
COMPARATIVE STUDY
Sara Marelli, Andrea Galbiati, Fabrizio Rinaldi, Enrico Giora, Alessandro Oldani, Luigi Ferini Strambi, Marco Zucconi
Restless Legs Syndrome/Willis Ekbom Disease (RLS/WED) is a common neurological disorder characterized by uncomfortable and unpleasant sensations in the legs, with an urge to move. The symptoms typically begin or worsen during periods of rest, in particular during the evening and at night, while the activity may typically relieve them. The majority of patients complains of poor sleep. Recent studies reported the prevalence is ranging from 5 to 10%. RLS/WED can be divided into primary (patients without associated conditions that may explain the symptoms) and secondary forms (mostly iron deficiency)...
June 2015: Archives Italiennes de Biologie
https://www.readbyqxmd.com/read/26725086/defining-the-phenotype-of-restless-legs-syndrome-willis-ekbom-disease-rls-wed-a-clinical-and-polysomnographic-study
#16
Fabrizio Rinaldi, Andrea Galbiati, Sara Marelli, Maria Cusmai, Alessandro Gasperi, Alessandro Oldani, Marco Zucconi, Alessandro Padovani, Luigi Ferini Strambi
Clinical features variability between familial and sporadic restless legs syndrome/Willis-Ekbom disease (RLS/WED) has been previously reported. With this retrospective cohort study, we aimed to determine the clinical and polysomnographic characteristics of 400 RLS/WED patients. Patients with familial RLS/WED were significantly younger than sporadic RLS/WED, while clinical and polysomnographic characteristics were similar in both groups. No difference was found for the age-at-onset between idiopathic and secondary RLS/WED...
February 2016: Journal of Neurology
https://www.readbyqxmd.com/read/26664128/medical-devices-for-restless-legs-syndrome-clinical-utility-of-the-relaxis-pad
#17
REVIEW
Ulrike H Mitchell
Restless Legs Syndrome or Willis-Ekbom Disease, a neurosensory disorder, can be treated with pharmaceuticals or conservatively. This review focuses on conservative treatments, more specifically on treatments with medical devices. Two modes of action, enhancement of circulation and counter stimulation, are introduced. Medical devices that use enhancement of circulation as their mechanism of action are whole body vibration, pneumatic compression, and near-infrared light. Medical devices that use counter stimulation include transcutaneous electrical nerve stimulation and the vibration Relaxis pad...
2015: Therapeutics and Clinical Risk Management
https://www.readbyqxmd.com/read/26619735/-restless-legs-syndrome-willis-ekbom-disease
#18
Élisabeth Ruppert, Marc Bataillard, Patrice Bourgin
Restless legs syndrome (RLS) is a sensorimotor disorder with a high prevalence (10% in Caucasian populations). It is a purely clinical diagnosis characterized by an urge to move the lower limbs usually accompanied or caused by unpleasant sensations in the legs with an improvement in symptoms with movement. These sensations occur during inactivity or at rest and worsen in the evening or at night. RLS may not only impact the quality of life for an individual, but may also increase mortality. Disease markers such as genetic predispositions have been identified, as well as reduced iron stores with altered intracerebral iron homeostasis and dopaminergic dysfunction...
September 2015: La Revue du Praticien
https://www.readbyqxmd.com/read/26545868/willis-ekbom-disease-is-not-associated-with-poor-cardiovascular-health-in-adults
#19
Brynn K Dredla, Oscar H Del Brutto, Augustine S Lee, Pablo R Castillo
BACKGROUND: Willis-Ekbom disease (WED), also called restless legs syndrome (RLS), is a neurologic sensorimotor disease that may be associated with cardiovascular disease. Given high morbidity and mortality rates of cardiovascular disease worldwide, we assessed the relation between WED/RLS and cardiovascular health risks in a native South American population. We prospectively analyzed data from The Atahualpa Project of Ecuadorian adults aged 40 years and older. Physicians interviewed consented persons on the health behavior and health factors of the American Heart Association (AHA) for ideal cardiovascular health in adults and underwent fasting laboratory blood collection and blood pressure evaluation...
2015: Journal of Negative Results in Biomedicine
https://www.readbyqxmd.com/read/26492111/the-relationship-between-willis-ekbom-disease-and-serum-ferritin-levels-among-children-in-northwestern-turkey
#20
Gulistan Halac, Gulsen M Sezer, Neslihan O Saglam, Pinar Tekturk, Aysegul D Demir, Saliha Demir, Faruk Akcay, Aysegul Uslu, Zuhal Yapıcı, Talip Asil
OBJECTIVE: To examine the incidence of restless legs syndrome (RLS) among children with iron deficiency, or iron deficiency anemia, or both, and the relationship between RLS prevalence and serum ferritin levels. METHODS: This prospective, cross-sectional, case controlled study was carried out between January and June 2013, and included 98 iron deficiency and/or iron deficiency anemia, and 102 healthy children referred to the Neurology and Pediatric Departments of the Medical Faculty of Bezmialem Vakif University, Istanbul, Turkey...
October 2015: Neurosciences: the Official Journal of the Pan Arab Union of Neurological Sciences
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