Lisa X Luan, Emma Eckernäs, Michael Ashton, Fernando E Rosas, Malin V Uthaug, Alexander Bartha, Samantha Jagger, Kiara Gascon-Perai, Lauren Gomes, David J Nutt, David Erritzøe, Robin L Carhart-Harris, Christopher Timmermann
N,N-Dimethyltryptamine (DMT) is a serotonergic psychedelic that induces a rapid and transient altered state of consciousness when inhaled or injected via bolus administration. Its marked and novel subjective effects make DMT a powerful tool for the neuroscientific study of consciousness and preliminary results show its potential role in treating mental health conditions. In a within-subjects, placebo-controlled study, we investigated a novel method of DMT administration involving a bolus injection paired with a constant-rate infusion, with the goal of extending the DMT experience...
January 2024: Journal of Psychopharmacology