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Osteoarthritis, Knee

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https://www.readbyqxmd.com/read/29656129/no-difference-in-implant-survivorship-and-clinical-outcomes-between-full-cementless-and-full-cemented-fixation-in-primary-total-knee-arthroplasty-a-systematic-review-and-meta-analysis
#1
REVIEW
Kai Zhou, Haoda Yu, Jinglong Li, Haoyang Wang, Zongke Zhou, Fuxing Pei
BACKGROUND: The debate over the use of cemented or cementless fixation in total knee arthroplasty (TKA) has never stopped since cementless fixation was introduced. We undertook a systematic review and meta-analysis to evaluate the optimal mode of fixation (full-cementless vs. full-cemented) in TKA. METHODS: PubMed, Embase, and the Cochrane Library databases up to July 2017 were searched to identify randomised controlled trials (RCTs) and quasi-RCTs comparing full-cementless TKA and full-cemented TKA...
April 12, 2018: International Journal of Surgery
https://www.readbyqxmd.com/read/29656073/protective-therapeutic-effects-of-peptide-nanofiber-and-hyaluronic-acid-hybrid-membrane-in-in-vivo-osteoarthritis-model
#2
Elif Arslan, Melis Sardan Ekiz, Cagla Eren Cimenci, Nuray Can, M Hanifi Gemci, Huseyin Ozkan, Mustafa O Guler, Ayse B Tekinay
Osteoarthritis (OA) is a condition where tissue function is lost through a combination of secondary inflammation and deterioration in articular cartilage. One of the most common causes of OA is age-related tissue impairment because of wear and tear due to mechanical erosion. Hyaluronic acid-based viscoelastic supplements have been widely used for the treatment of knee injuries. However, the current formulations of hyaluronic acid are unable to provide efficient healing and recovery. Here, a nanofiber-hyaluronic acid membrane system that was prepared by using a quarter of the concentration of commercially available hyaluronic acid supplement, Hyalgan® , was used for the treatment of an osteoarthritis model, and Synvisc® , which is another commercially available hyaluronic acid containing viscoelastic supplement, was used as a control...
April 12, 2018: Acta Biomaterialia
https://www.readbyqxmd.com/read/29651769/superolateral-hoffa-s-fat-pad-shfp-oedema-and-patellar-cartilage-volume-loss-quantitative-analysis-using-longitudinal-data-from-the-foundation-for-the-national-institute-of-health-fnih-osteoarthritis-biomarkers-consortium
#3
Arya Haj-Mirzaian, Ali Guermazi, Nima Hafezi-Nejad, Christopher Sereni, Michael Hakky, David J Hunter, Bashir Zikria, Frank W Roemer, Shadpour Demehri
OBJECTIVES: To determine the association of superolateral Hoffa's fat pad (SHFP) oedema and patellofemoral joint structural damage in participants of Foundation for the National Institute of Health Osteoarthritis Biomarkers Consortium study. METHODS: Baseline and 24-month MRIs of 600 subjects were assessed. The presence of SHFP oedema (using 0-3 grading scale) and patellar morphology metrics were determined using baseline MRI. Quantitative patellar cartilage volume and semi-quantitative MRI osteoarthritis knee score (MOAKS) variables were extracted...
April 12, 2018: European Radiology
https://www.readbyqxmd.com/read/29651561/survival-and-functional-outcome-of-high-tibial-osteotomy-for-medial-knee-osteoarthritis-a-10-20-year-cohort-study
#4
A F Y van Wulfften Palthe, N D Clement, O P P Temmerman, B J Burger
BACKGROUND: The primary aim of this study was to identify independent predictors of long-term survivorship after high tibial osteotomy (HTO). The secondary aims were to describe the functional outcome of surviving HTO 10-20 years after surgery. METHODS: A retrospective cohort of 223 HTO that were performed for the treatment of medial osteoarthritis was identified. Details were recorded from the patient notes. All surviving patients were contacted and asked to complete a Tegner Activity Scale, Lysholm Knee Score and rate pain using the Visual Analogue Scale (VAS)...
April 12, 2018: European Journal of Orthopaedic Surgery & Traumatology: Orthopédie Traumatologie
https://www.readbyqxmd.com/read/29651151/the-effect-of-ageing-and-osteoarthritis-on-the-mechanical-properties-of-cartilage-and-bone-in-the-human-knee-joint
#5
Abby E Peters, Riaz Akhtar, Eithne J Comerford, Karl T Bates
Osteoarthritis is traditionally associated with cartilage degeneration although is now widely accepted as a whole-joint disease affecting the entire osteochondral unit; however site-specific cartilage and bone material properties during healthy ageing and disease are absent limiting our understanding. Cadaveric specimens (n = 12; 31-88 years) with grades 0-4 osteoarthritis, were dissected and spatially correlated cartilage, subchondral and trabecular bone samples (n = 8 per cadaver) were harvested from femoral and tibial localities...
April 12, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29650603/top-studies-relevant-to-primary-care-practice
#6
REVIEW
Danielle Perry, Michael R Kolber, Christina Korownyk, Adrienne J Lindblad, Jamil Ramji, Joey Ton, G Michael Allan
OBJECTIVE: To summarize 10 high-quality studies from 2017 that have strong relevance to primary care practice. QUALITY OF EVIDENCE: Study selection involved routine literature surveillance by a group of primary care health professionals. This included screening abstracts of important journals and Evidence Alerts, as well as searching the American College of Physicians Journal Club. MAIN MESSAGE: Topics of the 2017 articles include whether treating subclinical hypothyroidism improves outcomes or symptoms; whether evolocumab reduces cardiovascular disease as well as low-density lipoprotein levels; whether lifestyle interventions reduce medication use in patients with diabetes; whether vitamin D prevents cardiovascular disease, cancer, or upper respiratory tract infections; whether canagliflozin reduces clinical events in patients with diabetes; how corticosteroid injections affect knee osteoarthritis; whether drained abscesses benefit from antibiotic treatment; whether patients with diabetes benefit from bariatric surgery; whether exenatide reduces clinical events in patients with diabetes; and whether tympanostomy tubes affect outcomes in recurrent acute otitis media or chronic otitis media...
April 2018: Canadian Family Physician Médecin de Famille Canadien
https://www.readbyqxmd.com/read/29650413/taurine-protects-against-knee-osteoarthritis-development-in-experimental-rat-models
#7
Yiqun Bian, Meng Zhang, Kai Wang
BACKGROUND: Osteoarthritis (OA) is one of the complex diseases that affect a large population of the world. The aim of the current study was to explore the roles of taurine in OA rat models, and discover the related mechanisms. METHODS: OA rat models were established by anterior cruciate ligament transection (ACLT) plus medial meniscus resection (MMx) surgery on the right knees. Secondary mechanical allodynia, weight-bearing alterations and knee joint width were evaluated before surgery and every two weeks after surgery...
April 9, 2018: Knee
https://www.readbyqxmd.com/read/29649709/the-relationship-between-the-dietary-inflammatory-index-dii-%C3%A2-and-incident-depressive-symptoms-a-longitudinal-cohort-study
#8
Nitin Shivappa, James R Hébert, Nicola Veronese, Maria Gabriella Caruso, Maria Notarnicola, Stefania Maggi, Brendon Stubbs, Joseph Firth, Michele Fornaro, Marco Solmi
BACKGROUND: Diet is a common source of inflammation, and inflammation is associated with depression. We examined the association between the dietary inflammatory index (DII® ), a validated measure of inflammatory potential of the diet, and risk of depression in a cohort of older North American adults. METHODS: This longitudinal study, with a follow-up of 8 years, included 3648 participants (1577 males, 2071 females; mean age: 60.6 years) with/at risk of knee osteoarthritis...
April 4, 2018: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29649270/the-quality-of-reporting-in-randomized-controlled-trials-of-acupuncture-for-knee-osteoarthritis-a-cross-sectional-survey
#9
Pengli Jia, Li Tang, Jiajie Yu, Jiali Liu, Deying Kang, Xin Sun
OBJECTIVE: To assess the reporting quality of acupuncture trials for knee osteoarthritis (KOA), and explore the factors associated with the reporting. METHOD: Three English and four Chinese databases were searched from inception to December 2016 for randomized control trials testing effects of acupuncture for knee osteoarthritis. We used the standard CONSORT (2010 version), CONSORT Extension for Non-Pharmacological Treatments, and STRICTA for measuring the quality of reporting...
2018: PloS One
https://www.readbyqxmd.com/read/29648688/quantitative-signal-intensity-alteration-in-infrapatellar-fat-pad-predict-incident-radiographic-osteoarthritis-the-osteoarthritis-initiative
#10
Kang Wang, Changhai Ding, Michael J Hannon, Zhongshan Chen, C Kent Kwoh, David J Hunter
OBJECTIVES: To determine if infrapatellar fat pad (IPFP) signal intensity (SI) measures are predictive of incident radiographic osteoarthritis (iROA) over 4 years in the OA Initiative (OAI) study. METHODS: Case knees (n=355) defined by iROA were matched one-to-one by gender, age and radiographic status with control knees. T2-weighted MR images were assessed at P0 (the visit when iROA was found on radiograph), P-1 (1 year prior to P0) and baseline, and utilized to assess IPFP SI semi-automatically using MATLAB...
April 12, 2018: Arthritis Care & Research
https://www.readbyqxmd.com/read/29648685/association-of-physical-examination-knee-effusion-with-bone-marrow-lesions-cross-sectional-and-longitudinal-analyses-of-a-population-based-cohort
#11
Jolanda Cibere, Ali Guermazi, Savvas Nicolaou, John M Esdaile, Anona Thorne, Joel Singer, Hubert Wong, Jacek A Kopec, Eric C Sayre
OBJECTIVE: To determine the association of physical examination (PE) effusion with prevalence of bone marrow lesions (BML) on MRI, and incidence/progression of BML over 3 years in knee osteoarthritis (OA). METHODS: A population-based cohort with knee pain (N=255) was assessed for PE effusion. On MRI, BML was graded 0-3 (none, mild, moderate, severe), incidence/progression defined as a worsening in the sum of BML scores over six surfaces by ≥1 grade. We analyzed the full cohort and mild disease subsample with Kellgren-Lawrence (KL) grade <3...
April 12, 2018: Arthritis Care & Research
https://www.readbyqxmd.com/read/29644876/the-effects-of-well-rounded-exercise-program-on-systemic-biomarkers-related-to-cartilage-metabolism
#12
Masayuki Azukizawa, Hiromu Ito, Yosuke Hamamoto, Takayuki Fujii, Yugo Morita, Akinori Okahata, Takuya Tomizawa, Moritoshi Furu, Kohei Nishitani, Shinichi Kuriyama, Shinichiro Nakamura, Hiroyuki Yoshitomi, Toshiaki Nakatani, Tadao Tsuboyama, Masahide Hamaguchi, Shuichi Matsuda, Tadashi Yasuda
Nonsurgical treatment such as exercise is the preferred method for management of knee osteoarthritis (OA). A combination of aerobic, muscle strengthening, and flexibility exercises is recommended for older adults. However, effects of the exercise intervention on cartilage metabolism remain unclear. This study used biomarkers to investigate the effects of well-rounded exercise program on cartilage metabolism in 42 women (mean age: 59 years). Participants started a weekly supervised exercise program and continued for 12 weeks...
April 1, 2018: Cartilage
https://www.readbyqxmd.com/read/29644875/a-single-intra-articular-injection-of-gel-200-for-treatment-of-symptomatic-osteoarthritis-of-the-knee-is-more-effective-than-phosphate-buffered-saline-at-6-months-a-subgroup-analysis-of-a-multicenter-randomized-controlled-trial
#13
Junko Takamura, Takayuki Seo, Vibeke Strand
Objective Many clinical trials of viscosupplementation have been conducted, although only the Gel-200 (primary) trial included a different patient population. A subgroup analysis of a multicenter, randomized controlled trial comparing the efficacy of single intra-articular injections of Gel-200 with phosphate buffered saline (PBS) was performed to demonstrate its benefit as treatment of osteoarthritis of the knee in a population similar to those of other reported trials of viscosupplementation. Design The subgroup population was defined as patients in the intention-to-treat (ITT) population who met the specified criteria...
April 1, 2018: Cartilage
https://www.readbyqxmd.com/read/29643693/joint-perception-and-patient-perceived-satisfaction-after-total-hip-and-knee-arthroplasty-in-the-american-population
#14
Matthew Varacallo, Rajit Chakravarty, Kevin Denehy, Andrew Star
Background: Total hip (THA) and knee arthroplasty (TKA) are two of the most successful procedures in orthopedics. Current evaluation trends focus on patient-reported outcomes. We sought to compare the changing WOMAC scores from various time points from pre-operative to 1-year follow-up between separate THA and TKA cohorts. In addition, we compared THA and TKA patients' joint perception, satisfaction, and function via a questionnaire. Methods: One hundred elective THA (n = 50) and TKA (n = 50) patients at one institution were randomly selected and contacted between 2 and 4 years after the index surgery...
June 2018: Journal of Orthopaedics
https://www.readbyqxmd.com/read/29643612/cognitive-behavioural-therapy-and-pain-coping-skills-training-for-osteoarthritis-knee-pain-management-a-systematic-review
#15
Ayah Ismail, Catherine Moore, Natasha Alshishani, Khalid Yaseen, Mansour Abdullah Alshehri
[Purpose] To investigate the effectiveness of cognitive-behavioural therapy (CBT) and pain coping skills training (PCST) on pain level in adults with osteoarthritis of the knee (KOA) in comparison with usual care. [Subjects and Methods] Five databases were systematically searched for relevant randomised controlled trials (RCTs) according to the selected eligibility criteria (inception to June 7, 2016). PEDro scale was used to assess the validity of included studies. [Results] Four studies met the inclusion criteria and all studies had high methodological quality...
December 2017: Journal of Physical Therapy Science
https://www.readbyqxmd.com/read/29643043/-shaoyangzhugu-formula-regulates-p19-arf-p53-p21-cip1-signaling-pathway-to-ameliorate-cartilage-degeneration-in-aged-cynomolgus-monkeys-with-knee-osteoarthritis
#16
Xin Zhou, Lei Zhang, Shi-Jie Fu, Gang Liu, Xiao-Guang Guo, Gang Yi, Yang Liu, Guo-You Wang
OBJECTIVE: To study the effect of Shaoyangzhugu (SYZG) Formula (a formula consisting of 9 traditional Chinese drugs) in delaying the degeneration of articular cartilage and the role p19Arf -p53-p21Cip1 signaling pathway in mediating this effect. METHOD: Thirteen aged cynomolgus monkeys with degenerative knee joints were selected based on X-ray findings, and one of them was randomly selected for pathological observation. The other monkeys were randomized equally into SYZG Formula group (treated with SYZG decoction), ammonia moxime group and saline group...
March 20, 2018: Nan Fang Yi Ke da Xue Xue Bao, Journal of Southern Medical University
https://www.readbyqxmd.com/read/29642931/bariatric-surgery-improves-knee-function-and-not-knee-pain-in-the-early-postoperative-period
#17
Amre Hamdi, Alia T Albaghdadi, Bayan Ghalimah, Abdullah Alnowiser, Anas Ahmad, Abdulmalik Altaf
BACKGROUND: Obesity remains the strongest predictor of knee osteoarthritis (OA). Studies have reported improvement in knee pain and function post-bariatric surgery secondary to weight loss and reduced mechanical loading, yet others found increased rates of total knee arthroplasty (TKA) in that patient population. To address this controversy, our study aimed to further assess the effect of surgically induced, "rapid" weight loss on knee pain and function. METHODS: Obese patients with chronic knee pain, who were undergoing bariatric surgery, were enrolled and surveyed preoperatively and 3 months postoperatively...
April 11, 2018: Journal of Orthopaedic Surgery and Research
https://www.readbyqxmd.com/read/29642918/the-impact-of-osteoarthritis-on-early-exit-from-work-results-from-a-population-based-study
#18
Pedro A Laires, Helena Canhão, Ana M Rodrigues, Mónica Eusébio, Miguel Gouveia, Jaime C Branco
BACKGROUND: Osteoarthritis (OA) is a leading cause of pain and disability, which may be a source of productivity losses. The objectives of this study were to describe the impact of OA, namely through pain and physical disability, on early exit from work and to calculate its economic burden. METHODS: We analysed data from the national, cross-sectional, population-based EpiReumaPt study (Sep2011-Dec2013) in which 10,661 individuals were randomly surveyed in order to capture all cases of rheumatic diseases...
April 11, 2018: BMC Public Health
https://www.readbyqxmd.com/read/29642914/development-of-the-italian-version-of-the-high-activity-arthroplasty-score-haas-i-following-hip-and-knee-total-arthroplasty-cross-cultural-adaptation-reliability-validity-and-sensitivity-to-change
#19
Marco Monticone, Antonio Capone, Luca Frigau, Giuseppe Marongiu, Paola Abelli, Francesco Mola, Nicola Maffulli, Calogero Foti
BACKGROUND: The number of physically active individuals who develop knee and hip arthritis and who undergo arthroplasties of these joints ie ever increasing. It has become necessary to develop evaluation scales which address the specific issues raised by such individuals. The High Activity Arthroplasty Score is one such scales, originally developed in English. METHODS: The HAAS-I was developed by means of forward-backward translation, a final review by an expert committee and a test of the pre-final version to establish its correspondence with the original English version...
April 11, 2018: Journal of Orthopaedic Surgery and Research
https://www.readbyqxmd.com/read/29629916/distal-femoral-varus-osteotomy-for-the-management-of-valgus-deformity-of-the-knee
#20
Seth L Sherman, Samuel F Thompson, John C F Clohisy
Distal femoral varus osteotomy is a well-described treatment option for patients with valgus malalignment associated with a variety of underlying conditions. This procedure may be the definitive treatment option in active patients with isolated lateral compartment osteoarthritis or posttraumatic arthritis. It may be a useful concomitant procedure in young patients with lateral meniscus deficiency, focal chondral defects, chronic medial collateral ligament insufficiency, and/or patellofemoral instability. Distal femoral varus osteotomy can be performed with medial closing wedge or lateral opening wedge techniques...
April 6, 2018: Journal of the American Academy of Orthopaedic Surgeons
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