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Osteoarthritis, Knee

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https://www.readbyqxmd.com/read/29245188/the-unmet-needs-of-aboriginal-australians-with-musculoskeletal-pain-a-mixed-method-systematic-review
#1
Ivan B Lin, Samantha Bunzli, Donna B Mak, Charmaine Green, Roger Goucke, Juli Coffin, Peter B O'Sullivan
OBJECTIVE: Musculoskeletal pain (MSP) conditions are the biggest cause of disability and internationally, Indigenous peoples experience a higher burden. There are conflicting reports about Aboriginal Australians and MSP. We conducted a systematic review to describe the prevalence, associated factors, impacts, care access, health care experiences, and factors associated with MSP among Aboriginal Australians. METHODS: A systematic search of quantitative and qualitative scientific and grey literature (PROSPERO number: CRD42016038342)...
December 15, 2017: Arthritis Care & Research
https://www.readbyqxmd.com/read/29245180/factors-influencing-cane-use-for-the-management-of-knee-osteoarthritis-a-cross-sectional-survey
#2
Julia Hart, Rana S Hinman, Ans Van Ginckel, Michelle Hall, Rachel Nelligan, Kim L Bennell
OBJECTIVE: To investigate demographic, symptom-related and cognitive determinants of cane use for knee osteoarthritis (OA) and prioritise the factors that could facilitate cane use in people with no previous cane use. METHODS: A survey of people aged ≥45 years with a clinical diagnosis of knee OA was conducted. The survey included two sections: i) demographic and cognitive determinants of cane use assessed via subscales of the Cane Cognitive Mediator Scale; ii) 19 statements, underpinned by the Behaviour Change Wheel theoretical framework, relating to factors that could facilitate regular cane use...
December 15, 2017: Arthritis Care & Research
https://www.readbyqxmd.com/read/29244223/fixed-bearing-medial-unicompartmental-knee-arthroplasty-restores-neither-the-medial-pivoting-behavior-nor-the-ligament-forces-of-the-intact-knee-in-passive-flexion
#3
Mohammad Kia, Lucian C Warth, Joseph D Lipman, Timothy M Wright, Geoffrey H Westrich, Michael B Cross, David J Mayman, Andrew D Pearle, Carl W Imhauser
Medial unicompartmental knee arthroplasty (UKA) is an accepted treatment for isolated medial osteoarthritis. However, using an improper thickness for the tibial component may contribute to early failure of the prosthesis or disease progression in the unreplaced lateral compartment. Little is known of the effect of insert thickness on both knee kinematics and ligament forces. Therefore, a computational model of the tibiofemoral joint was used to determine how non-conforming, fixed bearing medial UKA affects tibiofemoral kinematics and tension in the medial collateral ligament (MCL) and the anterior cruciate ligament (ACL) during passive knee flexion...
December 15, 2017: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/29243770/adipose-derived-stem-cells-in-articular-cartilage-regeneration-current-concepts-and-optimization-strategies
#4
REVIEW
Xingjian Gu, Caixin Li, Feng Yin, Guanghua Yang
Knee osteoarthritis (KOA) is the most common progressive joint disorder associated with disability in the world. As a chronic disease, KOA has multifactorial etiology. However, the poor self-healing ability of the articular cartilage due to its intrinsic tissue hypovascularity and hypocellularity seems to be directly incriminated in the physio-pathological mechanism of KOA. While conventional therapies result in unfavorable clinical outcomes, regenerative cell therapies have shown great promise in articular cartilage regeneration...
December 15, 2017: Histology and Histopathology
https://www.readbyqxmd.com/read/29243283/intra-articular-injection-of-autologous-adipose-derived-mesenchymal-stem-cells-in-treatment-of-knee-osteoarthritis
#5
Duško Spasovski, Vesna Spasovski, Zoran Baščarević, Maja Stojiljković, Miša Vreća, Marina Andjelković, Sonja Pavlović
BACKGROUND: Osteoarthritis (OA) is a chronic degenerative joint disease, considered to be the fourth leading cause of disability and the second cause of inability to work in men. Recently, adipose derived mesenchymal stem cells (AD-MSCs) came in focus of regenerative medicine as promising tool for treatment of OA. It has been shown that administration of stem cells into impaired joints results in pain relief and improves quality of life, accompanied with restoration of hyaline articular cartilage...
December 15, 2017: Journal of Gene Medicine
https://www.readbyqxmd.com/read/29243057/decreased-muscle-mass-is-independently-associated-with-knee-pain-in-female-patients-with-radiographically-mild-osteoarthritis-a-nationwide-cross-sectional-study-knhanes-2010-2011
#6
Hee Min Park, Ho Jae Kim, Byeori Lee, Minkyoung Kwon, Seung Min Jung, Sang-Won Lee, Yong-Beom Park, Jason Jungsik Song
To evaluate the association between muscle mass and knee pain in relation to radiographic severity of knee osteoarthritis. We consulted nationwide health examination and survey records collected from 2010 to 2011 and extracted data regarding female patients aged > 50 years and diagnosed with knee osteoarthritis. Radiographic severity was assessed on plain radiographs using the Kellgren-Lawrence system, whereas appendicular skeletal mass was obtained from dual-energy X-ray absorptiometry data. We performed multivariate logistic regression to evaluate the association between knee pain and muscle mass index (appendicular skeletal muscle mass divided by body weight in percentile) in patient groups stratified by radiographic severity of knee osteoarthritis...
December 14, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/29241343/can-biologic-augmentation-improve-clinical-outcomes-following-microfracture-for-symptomatic-cartilage-defects-of-the-knee-a-systematic-review
#7
Armin Arshi, Peter D Fabricant, Derek E Go, Riley J Williams, David R McAllister, Kristofer J Jones
Objective To perform a systematic review of clinical outcomes following microfracture augmented with biological adjuvants (MFX+) compared with microfracture (MFX) alone. Design The MEDLINE, Scopus, and Cochrane databases were searched for clinical studies on MFX+ for chondral defects of the knee. Study characteristics and clinical outcome score data were collected. Subjective synthesis was performed using data from randomized controlled studies to determine effect size of MFX+ procedures performed with either injectable or scaffold-based augmentation compared with MFX alone...
December 1, 2017: Cartilage
https://www.readbyqxmd.com/read/29240251/progenitor-cells-from-different-zones-of-human-cartilage-and-their-correlation-with-histopathological-osteoarthritis-progression
#8
V P Mantripragada, W A Bova, C Boehm, N S Piuzzi, N A Obuchowski, R J Midura, G F Muschler
Cell-based therapies development for the treatment of osteoarthritis (OA) requires an understanding of the disease progression and attributes of the cells resident in cartilage. This study focused on quantitative assessment of the concentration and biological potential of stem and progenitor cells resident in different zones of cartilage displaying macroscopic Outerbridge grade 1-2 OA, and their correlation with OA progression based on established histologic scoring system. Lateral femoral condyles were collected from fifteen patients with idiopathic OA and varus knees undergoing total knee arthroplasty...
December 14, 2017: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/29239664/efficacy-and-safety-of-twice-daily-sustained-release-paracetamol-formulation-for-osteoarthritis-pain-of-the-knee-or-hip-a-randomized-double-blind-placebo-controlled-twelve-week-study
#9
Kenneth Reed, Agron Collaku, Sebastian Moreira
OBJECTIVE: Evaluate efficacy and safety of an investigational, twice-daily sustained-release (SR) paracetamol formulation in subjects with knee or hip osteoarthritis (OA). METHODS: In this multicenter, double-blind, parallel study (NCT02311881), subjects with hip or knee OA were randomly assigned to SR paracetamol 2x1000 mg BID, extended-release (ER) paracetamol 2x665 mg TID, or placebo for 12 weeks. Primary endpoint was mean change from baseline through 12 weeks in WOMAC Osteoarthritis Index pain...
December 14, 2017: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/29239538/-do-degenerative-meniscal-tears-need-surgery
#10
Julien Billières, Hermès Miozzari, Anne Lübbeke, Didier Hannouche
Degenerative meniscal tears (DMT) are common, often asymptomatic, and are associated with early-stage knee osteoarthritis in patients over 35 years of age. Conservative treatment, including exercise, physiotherapy and pain medication, should be offered as a first management approach for patients with symptomatic DMT. The indication for partial arthroscopic meniscectomy should be considered carefully, and based on specific criteria. Recently, several randomized controlled studies comparing partial medial meniscectomy to conservative treatment or to a sham procedure have questioned the effectiveness of surgical treatment of these lesions...
December 13, 2017: Revue Médicale Suisse
https://www.readbyqxmd.com/read/29237617/bisphosphonates-a-therapeutic-option-for-knee-osteoarthritis
#11
EDITORIAL
Willem F Lems
No abstract text is available yet for this article.
December 13, 2017: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/29237499/risk-factors-for-first-hospitalization-due-to-meniscal-lesions-a-population-based-cohort-study-with-30%C3%A2-years-of-follow-up
#12
Tea Kontio, Markku Heliövaara, Harri Rissanen, Paul Knekt, Arpo Aromaa, Svetlana Solovieva
BACKGROUND: Meniscal lesions are among the most common injuries of the knee, yet limited epidemiologic data is available on their risk factors. We investigated the association of lifestyle factors and physical strenuousness of work on knee injuries with a focus on meniscal lesions. METHODS: We examined a nationally representative sample of persons aged 30 to 59 years, who participated in a comprehensive health examination (the Mini-Finland Health Survey). Subjects without any injury or osteoarthritis in the knee joint at baseline (n = 4713) were subsequently followed via the National Hospital Discharge Register up to 30 years...
December 13, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/29236934/sensory-motor-training-versus-resistance-training-among-patients-with-knee-osteoarthritis-randomized-single-blind-controlled-trial
#13
Aline Bassoli Gomiero, Andrea Kayo, Marcelo Abraão, Maria Stella Peccin, Antonio Jose Grande, Virginia Fernandes Trevisani
BACKGROUND: Osteoarthritis of the knee is defined as a progressive disease of the synovial joints and is characterized by failure of joint damage repair. The objective here was to compare the effectiveness of sensory-motor training versus resistance training among patients with knee osteoarthritis. DESIGN AND SETTING: Randomized, single-blinded controlled trial conducted at the outpatient service of the University of Santo Amaro. METHODS: A total of 64 patients were randomly assigned to sensory-motor training or resistance training...
December 7, 2017: São Paulo Medical Journal, Revista Paulista de Medicina
https://www.readbyqxmd.com/read/29234863/gait-analysis-in-short-term-follow-up-of-medial-opening-wedge-high-tibial-osteotomy
#14
Hésojy Gley Pereira Vital da Silva, Alessandro Rozim Zorzi, Heglayne Pereira Vital da Silva, João Batista de Miranda
BACKGROUND: Biomechanical gait changes are proposed as adaptations to medial knee osteoarthritis (OA), and little is known about which parameters can be modified early by high tibial osteotomy (HTO) surgery. The aim of this study was to identify early gait changes in a postoperative period of 6 months as compared to a control group, in three different spatial planes. METHODS: Twenty-one patients with OA were submitted to three-dimensional gait analysis preoperatively and 6 months after HTO surgery...
December 12, 2017: European Journal of Orthopaedic Surgery & Traumatology: Orthopédie Traumatologie
https://www.readbyqxmd.com/read/29234466/the-effect-of-variation-in-interpretation-of-the-la-trobe-radiographic-foot-atlas-on-the-prevalence-of-foot-osteoarthritis-in-older-women-the-chingford-general-population-cohort
#15
Peter McQueen, Lucy Gates, Michelle Marshall, Michael Doherty, Nigel Arden, Catherine Bowen
Background: The prevalence of foot osteoarthritis (OA) is much less understood than hip, knee and hand OA. The foot is anatomically complex and different researchers have investigated different joints with lack of methodological standardisation across studies. The La Trobe Foot Atlas (LFA) is the first to address these issues in providing quantitative assessment of radiographic foot OA, but has not been tested externally. The aim of this study was to evaluate three different interpretive approaches to using the LFA for grading OA when scoring is difficult due to indistinct views of interosseous space and joint contour...
2017: Journal of Foot and Ankle Research
https://www.readbyqxmd.com/read/29234447/clinical-efficacy-and-safety-of-benjakul-remedy-extract-for-treating-primary-osteoarthritis-of-knee-compared-with-diclofenac-double-blind-randomized-controlled-trial
#16
Patamaporn Rachawat, Piya Pinsornsak, Puritat Kanokkangsadal, Arunporn Itharat
Background: The purpose of this study was to investigate the clinical efficacy and safety of Benjakul (BJK) extract for treating primary osteoarthritis (OA) of the knee compared with diclofenac. Methods: A phase 2, double blind, randomized, and controlled study was conducted. The BJK group received 300 mg of BJK extract per day, while another group received 75 mg of diclofenac per day. All patients were followed up at 14 and 28 days. The changing of visual analogue scale (VAS) for pain, 100-meter walking times, the modified Thai WOMAC index scores, and the global assessment were evaluated for efficacy...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/29234210/pharmaceutical-approval-update
#17
Michele B Kaufman
Secnidazole (Solosec) for the one-dose treatment of bacterial vaginosis; triamcinolone acetonide extended-release injection (Zilretta) for osteoarthritis knee pain; and insulin aspart injection (Fiasp), a rapidacting human insulin analogue for glycemic control in diabetes mellitus.
December 2017: P & T: a Peer-reviewed Journal for Formulary Management
https://www.readbyqxmd.com/read/29234021/workflow-assessing-the-effect-of-gait-alterations-on-stresses-in-the-medial-tibial-cartilage-combined-musculoskeletal-modelling-and-finite-element-analysis
#18
K S Halonen, C M Dzialo, M Mannisi, M S Venäläinen, M de Zee, M S Andersen
Knee osteoarthritis (KOA) is most common in the medial tibial compartment. We present a novel method to study the effect of gait modifications and lateral wedge insoles (LWIs) on the stresses in the medial tibial cartilage by combining musculoskeletal (MS) modelling with finite element (FE) analysis. Subject's gait was recorded in a gait laboratory, walking normally, with 5° and 10° LWIs, toes inward ('Toe in'), and toes outward ('Toe out wide'). A full lower extremity MRI and a detailed knee MRI were taken...
December 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29233667/knee-confidence-in-youth-and-young-adults-at-risk-of-post-traumatic-osteoarthritis-3-10-years-following-intra-articular-knee-injury
#19
A M Ezzat, J L Whittaker, C Toomey, P K Doyle-Baker, M Brussoni, C A Emery
OBJECTIVES: To examine differences in knee confidence between individuals with a history of youth sport-related knee injury and uninjured controls. DESIGN: Historical cohort study. METHODS: Participants include 100 individuals who sustained a youth sport-related intra-articular knee injury 3-10 years previously and 100 age-, sex- and sport-matched uninjured controls. Outcomes included: Knee confidence (Knee Osteoarthritis and Outcome Score); fat mass index (FMI; dual-energy X-ray absorptiometry); and weekly physical activity (modified Godin-Shephard Leisure Time Questionnaire)...
November 26, 2017: Journal of Science and Medicine in Sport
https://www.readbyqxmd.com/read/29233184/effects-of-angelicae-pubescentis-and-loranthi-decotion-on-repairing-knee-joint-cartilages-in-rats
#20
Shun Lyu, Bin Ji, Wenwu Gao, Xianqi Chen, Xiaotao Xie, Junjie Zhou
BACKGROUND: Knee osteoarthritis (KOA) is a common orthopedics disease and its pathological changes at early stage are the damage and loss of articular cartilage. Traditional Chinese medicine (TCM) prescription contains multiple components and has the unique advantages of the diversity of targets.We compared the traditional Chinese medical formulae (Angelicae Pubescentis and Loranthi decotion, APLD, or Duhuo Jisheng) with a western medicine (glucosamine sulfate, GS) to treat the rat arthritis models, and tracked the outcomes...
December 12, 2017: Journal of Orthopaedic Surgery and Research
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