P Krebs, M Nägele, P Fomina, V Virtanen, E Nippolainen, R Shaikh, I O Afara, J Töyräs, I Usenov, T Sakharova, V Artyushenko, V Tafintseva, J H Solheim, B Zimmermann, A Kohler, O König, S Saarakkala, B Mizaikoff
OBJECTIVE: A prototype infrared attenuated total reflection (IR-ATR) laser spectroscopic system designed for in vivo classification of human cartilage tissue according to its histological health status during arthroscopic surgery is presented. Prior to real-world in vivo applications, this so-called osteoarthritis (OA) scanner has been tested at in vitro conditions revealing the challenges associated with complex sample matrices and the accordingly obtained sparse spectral datasets. METHODS: In vitro studies on human knee cartilage samples at different contact pressures (i...
June 2024: Osteoarthritis and cartilage open