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Osteoarthritis, Knee

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https://www.readbyqxmd.com/read/29471592/what-can-our-hands-tell-us-about-the-future-of-our-knees
#1
EDITORIAL
Jamie E Collins
Knee osteoarthritis (OA) affects 14 million individuals in the United States and over 250 million adults worldwide1,2 . OA of the lower extremities is associated with decreased quality of life and increased healthcare utilization3 . Recent estimates suggest that knee OA should not merely be considered a disease of aging - in the US alone more than half of those affected are under age 65, while close to 15% are under age 452 . This article is protected by copyright. All rights reserved.
February 22, 2018: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/29471581/association-of-quantitative-and-topographic-assessment-of-heberden-s-nodes-with-knee-osteoarthritis-data-from-osteoarthritis-initiative
#2
Neil Kumar, Nima Hafezi-Nejad, Ali Guermazi, Arya Haj-Mirzaian, Ida K Haugen, Frank W Roemer, Shadpour Demehri
OBJECTIVE: To determine whether the presence, number, and topography (digit location and symmetry) of Heberden's nodes (HNs) are associated with radiographic knee osteoarthritis (OA) incidence and progression. METHODS: 8023 knees from the Osteoarthritis Initiative (OAI) were analyzed (8-years follow-up). Cox regression was performed on HN presence, total number, location, and symmetry (using two symmetry index models) obtained at baseline physical-examination as well as self-report of HN presence for evaluation of association with radiographic knee OA incidence (development of Kellgren-Lawrence grade≥2) and progression (worsening medial joint space narrowing score≥1)...
February 22, 2018: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/29471559/-suturing-an-acute-acl-lesion-with-dynamic-intraligamentary-stabilisation
#3
Christoph Ihle, H Nakayama, Christoph Gonser, Ulrich Stöckle, Stefan Döbele, Steffen Schröter, Marc-Daniel Ahrend, Atesch Ateschrang
BACKGROUND: The established surgical technique for lesion of the anterior cruciate ligament (ACL) is reconstruction with an autologous tendon. However, patients after ACL-replacement have increased osteoarthritis rates. Possible explanations are persistent knee instability and the loss of the ACL's proprioceptive function. Therefore, surgeons have developed an alternative treatment to preserve the ACL by readapting femoral ACL lesions by temporary protective dynamic intraligamentary stabilisation (DIS)...
February 2018: Zeitschrift Für Orthopädie und Unfallchirurgie
https://www.readbyqxmd.com/read/29471191/peak-knee-biomechanics-and-limb-symmetry-following-unilateral-anterior-cruciate-ligament-reconstruction-associations-of-walking-gait-and-jump-landing-outcomes
#4
Steven J Pfeiffer, J Troy Blackburn, Brittney Luc-Harkey, Matthew S Harkey, Laura E Stanley, Barnett Frank, Darin Padua, Stephen W Marshall, Jeffrey T Spang, Brian Pietrosimone
BACKGROUND: Aberrant walking-gait and jump-landing biomechanics may influence the development of post-traumatic osteoarthritis and increase the risk of a second anterior cruciate ligament injury, respectively. It remains unknown if individuals who demonstrate altered walking-gait biomechanics demonstrate similar altered biomechanics during jump-landing. Our aim was to determine associations in peak knee biomechanics and limb-symmetry indices between walking-gait and jump-landing tasks in individuals with a unilateral anterior cruciate ligament reconstruction...
January 31, 2018: Clinical Biomechanics
https://www.readbyqxmd.com/read/29471154/tibial-component-sizing-and-alignment-of-tkr-components-does-not-significantly-affect-patient-reported-outcome-measures-at-six-months-a-case-series-of-474-participants
#5
Imran Ahmed, Vlad Paraoan, Dveej Bhatt, Bhanu Mishra, Chetan Khatri, Damian Griffin, Andrew Metcalfe, Tim Barlow
OBJECTIVES: Total knee replacement (TKR) is an effective means of alleviating the symptoms of end stage osteoarthritis. However, 20% of patients report dissatisfaction one year post-operatively. Previous literature has demonstrated contradictory evidence regarding the relationship between alignment and tibial component sizing with patient reported outcome measures (PROMs). We aim to investigate the association between alignment of TKR components and effect of tibial component sizing on PROMs...
February 19, 2018: International Journal of Surgery
https://www.readbyqxmd.com/read/29470739/the-association-between-osteoarthritis-and-sleep-duration-in-koreans-a-nationwide-cross-sectional-observational-study
#6
Jae Hyun Jung, Hongdeok Seok, Sung Jae Choi, Junwoo Bae, Sang Hoon Lee, Moo Hwa Lee, Jae-Hoon Kim, Gwan Gyu Song
Osteoarthritis (OA) causes chronic pain, physical disability, and mental health deterioration and reduces the quality of life of patients. Sleep is an important factor in the recovery, and adequate sleep is important for quality of life. Several features of patients with OA can affect sleep time, and sleep also affects OA. We investigated the relationship between OA and sleep duration. Data for 2010-2012 were collected from the Korea National Health and Nutrition Examination Survey. We included 11,540 participants (4915 men and 6625 women)...
February 22, 2018: Clinical Rheumatology
https://www.readbyqxmd.com/read/29469223/mitoprotective-therapy-preserves-chondrocyte-viability-and-prevents-cartilage-degeneration-in-an-ex-vivo-model-of-posttraumatic-osteoarthritis
#7
Michelle L Delco, Edward D Bonnevie, Hazel S Szeto, Lawrence J Bonassar, Lisa A Fortier
No disease-modifying osteoarthritis (OA) drugs are available to prevent posttraumatic osteoarthritis (PTOA). Mitochondria (MT) mediate the pathogenesis of many degenerative diseases, and recent evidence indicates that MT dysfunction is a peracute (within minutes to hours) response of cartilage to mechanical injury. The goal of this study was to investigate cardiolipin-targeted mitoprotection as a new strategy to prevent chondrocyte death and cartilage degeneration after injury. Cartilage was harvested from bovine knee joints and subjected to a single, rapid impact injury (24...
February 22, 2018: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/29468844/are-older-adults-with-symptomatic-knee-osteoarthritis-less-active-than-the-general-population-analysis-from-the-osteoarthritis-initiative-and-nhanes
#8
Louise M Thoma, Dorothy Dunlop, Jing Song, Jungwha Lee, Catrine Tudor-Locke, Elroy J Aguiar, Hiral Master, Meredith B Christiansen, Daniel K White
OBJECTIVE: To compare objectively-measured physical activity (PA) in older adults with symptomatic knee osteoarthritis (SxOA) with similarly aged adults without osteoarthritis (OA) or knee symptoms from the general population. METHODS: We included people age 50-85 years with SxOA from the Osteoarthritis Initiative (OAI, n=491), and people age 50-85 years from the general population from the National Health and Nutrition Examination Survey (NHANES, n=449). A uniaxial accelerometer was worn for >10 hours/day for >4 days in the NHANES in 2003-2004 (Actigraph 7124) and in the OAI in 2008-2010 (Actigraph GT1M)...
February 22, 2018: Arthritis Care & Research
https://www.readbyqxmd.com/read/29468518/cultural-factors-influencing-osteoarthritis-care-in-asian-communities-a-review-of-the-evidence
#9
REVIEW
Thrmiga Sathiyamoorthy, Shabana Amanda Ali, Marita Kloseck
With the prevalence of osteoarthritis (OA) increasing internationally, there is a need to study the impact of this disease on culturally diverse populations. Individuals of Asian descent make up more than 60% of the world population, yet comprehensive information on the cultural factors that impact OA care is not available. Scoping review methodology using directed content analysis was employed to identify and analyze existing research on OA care for Asians. A categorization matrix was developed using the six care areas from the OA clinical practice guidelines along with an additional three non-clinical areas (cross-cultural adaptation of clinical tools; psychological well-being; family systems and informal care) identified in an initial scan resulting in a total of nine OA care areas to guide initial coding...
February 21, 2018: Journal of Community Health
https://www.readbyqxmd.com/read/29468171/influence-of-meniscal-and-chondral-lesions-on-patient-reported-outcomes-after-primary-anterior-cruciate-ligament-reconstruction-at-2-year-follow-up
#10
Mark E Cinque, Jorge Chahla, Justin J Mitchell, Gilbert Moatshe, Jonas Pogorzelski, Colin P Murphy, Nicholas I Kennedy, Jonathan A Godin, Robert F LaPrade
Background: Meniscal and chondral lesions are commonly associated with anterior cruciate ligament (ACL) tears, and these lesions may play a role in patient outcomes after ACL reconstruction. Purpose: To determine the effects of the presence and location of meniscal and chondral lesions at the time of ACL reconstruction on patient-reported outcomes at a minimum 2-year follow-up. Study Design: Cohort study; Level of evidence, 3. Methods: Patients with no prior knee surgery who underwent primary ACL reconstruction by a single surgeon between 2010 and 2014 were included in this study...
February 2018: Orthopaedic Journal of Sports Medicine
https://www.readbyqxmd.com/read/29467586/an-observational-1-month-trial-on-the-efficacy-and-safety-of-promerim-for-improving-knee-joint
#11
Bekir Eray Kilinc, Yunus Oc, Gungor Alibakan, Emre Bilgin, Muharrem Kanar, Osman Tugrul Eren
Objective: This study was conducted to evaluate the efficacy and tolerability of the oral intake of promerim in the elimination of acute pain and discomfort associated with knee osteoarthritis (OA). Methods: Single-center, 1-month, prospective, observational clinical trial. A total of 92 patients not older than 70 years were included. Patients were offered to use 720-mg promerim for the first 15 days after admission after breakfast and then 360 mg for the second 15 days...
2018: Clinical Medicine Insights. Arthritis and Musculoskeletal Disorders
https://www.readbyqxmd.com/read/29466081/kinesio-taping-improves-perceptions-of-pain-and-function-of-patients-with-knee-osteoarthritis-a-randomized-controlled-trial
#12
Anna Lina Rahlf, Klaus-Michael Braumann, Astrid Zech
CONTEXT: Although increasingly used for therapeutic treatment only limited evidence exists regarding the effects of kinesio taping on patients with knee osteoarthritis. OBJECTIVE: To determine the effects of kinesio taping on pain, function, gait and neuromuscular control concerning patients with knee osteoarthritis (OA). DESIGN: Randomized sham-controlled trial. SETTING: University laboratory. PARTICIPANTS: 141 Patients (65...
February 21, 2018: Journal of Sport Rehabilitation
https://www.readbyqxmd.com/read/29465369/altered-gene-expression-profiles-of-histone-lysine-methyltransferases-and-demethylases-in-rheumatoid-arthritis-synovial-fibroblasts
#13
Yasuto Araki, Yoshimi Aizaki, Kojiro Sato, Hiromi Oda, Riki Kurokawa, Toshihide Mimura
OBJECTIVES: Aberrant histone lysine methylation (HKM) has been reported in rheumatoid arthritis (RA) synovial fibroblasts (SFs). As histone lysine methyltransferases (HKMTs) and demethylases (HKDMs) regulate HKM, these enzymes are believed to be dysregulated in RASFs. The aim of this study is to clarify whether gene expressions of HKMTs and HKDMs are altered in RASFs. METHODS: SFs were isolated from synovial tissues obtained from RA or osteoarthritis (OA) patients during total knee joint replacement...
January 31, 2018: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/29465368/comparative-effectiveness-of-glucosamine-chondroitin-acetaminophen-or-celecoxib-for-the-treatment-of-knee-and-or-hip-osteoarthritis-a-network-meta-analysis
#14
Xiaoyue Zhu, Dandong Wu, Lingli Sang, Yidan Wang, Yi Shen, Xun Zhuang, Minjie Chu, Liying Jiang
OBJECTIVES: To compare the efficacies of oral glucosamine, chondroitin, the combination of glucosamine and chondroitin, acetaminophen and celecoxib on the treatment of knee and/or hip osteoarthritis. METHODS: We searched electronic databases including PubMed, Embase, and Cochrane Library and the reference lists of relevant articles published from inception to October 23, 2017. A Bayesian hierarchical random effects model was used to examine the overall effect size among mixed multiple interventions...
January 31, 2018: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/29465334/association-of-mucoid-degeneration-of-the-anterior-cruciate-ligament-at-mr-imaging-with-medial-tibiofemoral-osteoarthritis-progression-at-radiography-data-from-the-osteoarthritis-initiative
#15
Robert M Kwee, Nima Hafezi-Nejad, Frank W Roemer, Bashir A Zikria, David J Hunter, Ali Guermazi, Shadpour Demehri
Purpose To determine whether anterior cruciate ligament (ACL) mucoid degeneration in participants with or at risk for osteoarthritis is associated with longitudinal risk of radiographic progression of medial tibiofemoral compartment joint space loss (JSL). Materials and Methods Baseline demographic, clinical, radiographic, and Magnetic Resonance (MR) Imaging Osteoarthritis Knee Score (MOAKS) data were evaluated in 600 participants from the Osteoarthritis Initiative database. Two blinded musculoskeletal radiologists independently evaluated baseline MR images for ACL mucoid degeneration...
February 21, 2018: Radiology
https://www.readbyqxmd.com/read/29464336/current-concepts-in-joint-pain-in-knee-osteoarthritis
#16
REVIEW
K Mills, M Hübscher, H O'Leary, N Moloney
Joint pain attributable to osteoarthritis (OA) is complex and influenced by a myriad of factors beyond local joint pathology. Current practice continues to predominantly adopt a biomedical approach to OA despite emerging evidence of the importance of a more holistic approach. This paper will summarise evidence for the presence of multidimensional pain profiles in knee joint pain and the presence of subgroups characterized by systemic features such as psychological distress, high comorbidity load or sensitisation of the nervous system...
February 20, 2018: Der Schmerz
https://www.readbyqxmd.com/read/29463254/spinacia-oleracea-extract-attenuates-disease-progression-and-sub-chondral-bone-changes-in-monosodium-iodoacetate-induced-osteoarthritis-in-rats
#17
Dharmendra Choudhary, Priyanka Kothari, Ashish Kumar Tripathi, Sonu Singh, Sulekha Adhikary, Naseer Ahmad, Sudhir Kumar, Kapil Dev, Vijay Kumar Mishra, Shubha Shukla, Rakesh Maurya, Prabhat R Mishra, Ritu Trivedi
BACKGROUND: Spinacia oleracea is an important dietary vegetable in India and throughout the world and has many beneficial effects. It is cultivated globally. However, its effect on osteoarthritis that mainly targets the cartilage cells remains unknown. In this study we aimed to evaluate the anti-osteoarthritic and chondro-protective effects of SOE on chemically induced osteoarthritis (OA). METHODS: OA was induced by intra-patellar injection of monosodium iodoacetate (MIA) at the knee joint in rats...
February 20, 2018: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/29462464/determining-brain-mechanisms-that-underpin-analgesia-induced-by-the-use-of-pain-coping-skills
#18
Leonie J Cole, Kim L Bennell, Yasmin Ahamed, Christina Bryant, Francis Keefe, G Lorimer Moseley, Paul Hodges, Michael J Farrell
Objective: Cognitive behavioral therapies decrease pain and improve mood and function in people with osteoarthritis. This study assessed the effects of coping strategies on the central processing of knee pain in people with osteoarthritis of the knees. Methods: Mechanical pressure was applied to exacerbate knee pain in 28 people with osteoarthritis of the knee. Reports of pain intensity and functional magnetic resonance imaging measures of pain-related brain activity were recorded with and without the concurrent use of pain coping skills...
February 16, 2018: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/29462069/the-association-between-body-mass-index-and-the-prevalence-severity-and-frequency-of-low-back-pain-data-from-the-osteoarthritis-initiative
#19
Charles A Su, David J Kusin, Samuel Q Li, Uri M Ahn, Nicholas U Ahn
STUDY DESIGN: Cross-sectional study. OBJECTIVE: To determine whether there is an association between body mass index (BMI) and the prevalence, severity, and frequency of low back pain and identify other potential patient risk factors for the development of low back pain. SUMMARY OF BACKGROUND DATA: Many studies have implicated that a high BMI is a risk factor for low back pain. However, few studies have examined the association between increased BMI and the prevalence, severity, and frequency of low back pain...
February 16, 2018: Spine
https://www.readbyqxmd.com/read/29460983/transcriptional-profiling-of-synovium-in-a-porcine-model-of-early-post-traumatic-osteoarthritis
#20
Jakob T Sieker, Benedikt L Proffen, Kimberly A Waller, Kaitlyn E Chin, Naga Padmini Karamchedu, Matthew R Akelman, Gabriel S Perrone, Ata M Kiapour, Johannes Konrad, Braden C Fleming, Martha M Murray
To determine the transcriptional profile of synovium during the molecular phase of post-traumatic osteoarthritis, anterior cruciate ligament transections (ACL) were performed in 36 Yucatan minipigs. Equal numbers were randomly assigned to no further treatment, ACL reconstruction or repair. Perimeniscal synovium for histopathology and RNA-sequencing was harvested at 1 and 4 weeks post-operatively and from 6 healthy control animals. Microscopic synovitis scores significantly worsened at 1 (p < 0.001) and 4 weeks (p = 0...
February 20, 2018: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
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