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Osteoarthritis, Knee

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https://www.readbyqxmd.com/read/29928576/cyclic-compressive-loading-activates-angiotensin-ii-type-1-receptor-in-articular-chondrocytes-and-stimulates-hypertrophic-differentiation-through-a-g-protein-dependent-pathway
#1
Fumihisa Nakamura, Ichiro Tsukamoto, Shinji Inoue, Kazuhiko Hashimoto, Masao Akagi
Angiotensin II type 1 receptor (AT1R) appears to have a mechanosensing function in a number of cell types. The purpose of this study was to examine whether AT1R expressed in articular chondrocytes is involved in osteoarthritis (OA) progression in vivo and whether cyclic compressive loading activates the AT1R and stimulates hypertrophic differentiation of chondrocytes in vitro . The relationships between the modified Mankin score for cartilage degeneration and the expression of AT1R and type X collagen (Col X) were studied in mouse knees with OA induced using the destabilization-of-medial-meniscus model...
June 2018: FEBS Open Bio
https://www.readbyqxmd.com/read/29928231/carnosine-prevents-type-2-diabetes-induced-osteoarthritis-through-the-ros-nf-%C3%AE%C2%BAb-pathway
#2
Yue Yang, Yang Wang, Yawei Kong, Xiaoning Zhang, He Zhang, Yi Gang, Lunhao Bai
Background: The anti-inflammatory and antioxidant capacity of carnosine (CAR) has been investigated in autoimmune diseases. The aim of this study was to evaluate the potential protective effects of oral CAR supplements to ameliorate type 2 diabetes mellitus (T2DM)-induced osteoarthritis (OA) in rats and its mechanism. Methods: Seventy male Sprague-Dawley rats were randomly divided into the control group (CG, n = 10) and the T2DM group ( n = 60). A rat model of T2DM was established using a high fat diet and streptozotocin (30 mg/kg, i...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29927640/does-anterior-cruciate-ligament-reconstruction-improve-functional-and-radiographic-outcomes-over-nonoperative-management-5-years-after-injury
#3
Elizabeth Wellsandt, Matthew J Failla, Michael J Axe, Lynn Snyder-Mackler
BACKGROUND: Current practice patterns for the management of anterior cruciate ligament (ACL) injury favor surgical reconstruction. However, long-term outcomes may not differ between patients completing operative and nonoperative treatment of ACL injury. Differences in outcomes between operative and nonoperative treatment of patients in the United States is largely unknown, as are outcomes in long-term strength and performance measures. PURPOSE: To determine if differences exist in 5-year functional and radiographic outcomes between patients completing operative and nonoperative treatment of ACL injury when both groups complete a progressive criterion-based rehabilitation protocol...
June 1, 2018: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/29926748/eurovisco-recommendations-for-optimizing-the-clinical-results-of-viscosupplementation-in-osteoarthritis
#4
Thierry Conrozier, Jordi Monfort, Xavier Chevalier, Raghu Raman, Pascal Richette, Demirhan Diraçoglù, Hervé Bard, Dominique Baron, Jörg Jerosch, Alberto Migliore, Yves Henrotin
Objectives The 3 aims of the work were to identify population subgroups that can benefit the most from viscosupplementation (VS), to provide recommendations on injection techniques, and to discuss VS appropriateness in clinical situations that are commonplace in daily practice. Methods The task force members voted on their degree of agreement on 27 statements, 36 recommendations, and 22 clinical scenarios using a 9-point scale. The strength of agreement/appropriateness/recommendation (SOA/SOR) was classified as strong if the median agreement score was ≥8...
June 1, 2018: Cartilage
https://www.readbyqxmd.com/read/29926706/effects-of-id-cbt5101-to-prevent-and-alleviate-osteoarthritis-1-symptoms-in-a-monosodium-iodoacetate-induced-rat-model
#5
Boo-Yong Sim, Hak-Joo Choi, Min-Goo Kim, Dong-Gu Jeong, Don-Gil Lee, Jong-Min Yoon, Dae-Jung Kang, Soobong Park, Joong-Gu Ji, In-Hwan Joo, Dong-Hee Kim
Osteoarthritis is a disease that affects the articular cartilage and osseous tissue, and can be worsened by aging, overweight status, and post-traumatic arthritis. The present study aimed to evaluate the effect of ID-CBT5101 (tyndallized Clostridium butyricum ) on bone metabolism and the inflammatory response in a monosodium iodoacetate-induced rat model of osteoarthritis. ID-CBT5101 was administered orally at doses of 108 CFU/day or 1010 CFU/day for 2 weeks before direct injection of monosodium iodoacetate (3 mg/50 µL of 0...
May 11, 2018: Journal of Microbiology and Biotechnology
https://www.readbyqxmd.com/read/29926686/-the-therapeutic-effects-of-yougui-pill-on-knee-osteoarthritis-and-the-expression-of-wnt-signal-pathway-related-factors-in-rats
#6
Chun-Lu Yan, Sheng-Hua Li, Fang-Yu An, Yong-Qi Liu, Peng-Fei Xia, Zheng-Min Ma, Yan-Qiang Niu, Peng-Yao Liu
OBJECTIVES: To observe the effects of Yougui pill (Traditional Chinese Medicine) on the related factors of Wnt signal pathway of rats with knee osteoarthritis (KOA), and explore its protective mechanism. METHODS: Sixty SPF SD rats were randomly divided into the sham-operative group, model group, glucosamine sulfate group, high-dose, middle-dose, low-dose of Yougui pill treated group ( n =10). KOA model was established by modified Hulth method for six weeks. The rats in the high, middle and low-dose of Yougui pill group were treated with Yougui pills at the doses of 20,10 and 5 g/kg respectively by gastrogavage once a day for 8 weeks, while equal volume of normal saline was given to those in the sham and model control group and an equal volume of glucosamine sulfate (1...
February 8, 2018: Chinese Journal of Applied Physiology
https://www.readbyqxmd.com/read/29923670/in-situ-depot-for-continuous-evolution-of-gaseous-h2-mediated-by-magnesium-passivation-activation-cycle-for-treating-osteoarthritis
#7
Wei-Lin Wan, Yu-Jung Lin, Po-Chien Shih, Yu-Ru Bow, Qinghua Cui, Yen Chang, Wei-Tso Chia, Hsing-Wen Sung
Inflammation is involved in many human pathologies, including osteoarthritis (OA). Hydrogen (H2) is known to have anti-inflammatory effects; however, the bioavailability of directly administered H2 gas is typically poor. Herein, a local delivery system that can provide a high therapeutic concentration of gaseous H2 at inflamed tissues is proposed. The delivery system comprises poly(lactic-co-glycolic acid) microparticles that contain magnesium powder (Mg@PLGA MPs). Mg@PLGA MPs that are intra-muscularly injected close to the OA knee in a mouse model can act as an in situ depot that can evolve gaseous H2 continuously, mediated by the cycle of passivation/activation of Mg in body fluids, at a concentration that exceeds its therapeutic threshold...
June 20, 2018: Angewandte Chemie
https://www.readbyqxmd.com/read/29923535/prevalence-of-osteoarthritis-of-knee-joint-among-adult-population-in-a-rural-area-of-kanchipuram-district-tamil-nadu
#8
Jayaseelan Venkatachalam, Murugan Natesan, Muthurajesh Eswaran, Abel K Samuel Johnson, V Bharath, Zile Singh
Background: Osteoarthritis (OA) is one of the most common degenerative disorders among the elderly population; although aging is the most important cause, research has shown that it is a complex disease with many etiologies. It is not an inevitable part of aging but rather the result of a combination of factors, many of which can be modified or prevented. Objective: The objective of this study was to assess the burden and determinants of OA knee among the adult population...
April 2018: Indian Journal of Public Health
https://www.readbyqxmd.com/read/29922745/first-in-human-randomized-clinical-trials-of-the-safety-and-efficacy-of-tanezumab-for-treatment-of-chronic-knee-osteoarthritis-pain-or-acute-bunionectomy-pain
#9
Patricia A Walicke, Franz Hefti, Roxanne Bales, Shiao-Ping Lu, Jon L Ruckle, Mark T Brown, Christine R West, David L Shelton
Introduction: The neurotrophin nerve growth factor has a demonstrated role in pain transduction and pathophysiology. Objectives: Two randomized, double-blind, placebo-controlled, phase 1 studies were conducted to evaluate safety, tolerability, and analgesic efficacy of single doses of tanezumab, a humanized anti-nerve growth factor monoclonal antibody, in chronic or acute pain. Methods: In the first study (CL001), patients with moderate to severe pain from osteoarthritis (OA) of the knee received a single intravenous infusion of tanezumab (3-1000 μg/kg) or placebo in a dose-escalation (part 1; N = 42) or parallel-arm (part 2; N = 79) study design...
May 2018: Pain Reports (Baltimore, Md.)
https://www.readbyqxmd.com/read/29922454/use-of-integrative-epigenetic-and-mrna-expression-analyses-to-identify-significantly-changed-genes-and-functional-pathways-in-osteoarthritic-cartilage
#10
A He, Y Ning, Y Wen, Y Cai, K Xu, Y Cai, J Han, L Liu, Y Du, X Liang, P Li, Q Fan, J Hao, X Wang, X Guo, T Ma, F Zhang
Aim: Osteoarthritis (OA) is caused by complex interactions between genetic and environmental factors. Epigenetic mechanisms control the expression of genes and are likely to regulate the OA transcriptome. We performed integrative genomic analyses to define methylation-gene expression relationships in osteoarthritic cartilage. Patients and Methods: Genome-wide DNA methylation profiling of articular cartilage from five patients with OA of the knee and five healthy controls was conducted using the Illumina Infinium HumanMethylation450 BeadChip (Illumina, San Diego, California)...
May 2018: Bone & Joint Research
https://www.readbyqxmd.com/read/29922445/high-fat-high-sucrose-diet-induced-obesity-results-in-joint-specific-development-of-osteoarthritis-like-degeneration-in-a-rat-model
#11
K H Collins, D A Hart, R A Seerattan, R A Reimer, W Herzog
Objectives: Metabolic syndrome and low-grade systemic inflammation are associated with knee osteoarthritis (OA), but the relationships between these factors and OA in other synovial joints are unclear. The aim of this study was to determine if a high-fat/high-sucrose (HFS) diet results in OA-like joint damage in the shoulders, knees, and hips of rats after induction of obesity, and to identify potential joint-specific risks for OA-like changes. Methods: A total of 16 male Sprague-Dawley rats were allocated to either the diet-induced obesity group (DIO, 40% fat, 45% sucrose, n = 9) or a chow control diet (n = 7) for 12 weeks...
April 2018: Bone & Joint Research
https://www.readbyqxmd.com/read/29922442/comparison-of-pain-behaviour-and-osteoarthritis-progression-between-anterior-cruciate-ligament-transection-and-osteochondral-injury-in-rat-models
#12
T Tawonsawatruk, O Sriwatananukulkit, W Himakhun, W Hemstapat
Objectives: In this study, we compared the pain behaviour and osteoarthritis (OA) progression between anterior cruciate ligament transection (ACLT) and osteochondral injury in surgically-induced OA rat models. Methods: OA was induced in the knee joints of male Wistar rats using transection of the ACL or induction of osteochondral injury. Changes in the percentage of high limb weight distribution (%HLWD) on the operated hind limb were used to determine the pain behaviour in these models...
March 2018: Bone & Joint Research
https://www.readbyqxmd.com/read/29921309/is-local-platelet-rich-plasma-injection-clinically-superior-to-hyaluronic-acid-for-treatment-of-knee-osteoarthritis-a-systematic-review-of-randomized-controlled-trials
#13
Yalong Di, Changxu Han, Liang Zhao, Yizhong Ren
BACKGROUND: In this study, we evaluated whether platelet-rich plasma (PRP) is superior to hyaluronic acid (HA) in the treatment of knee osteoarthritis. METHODS: The Cochrane Central Register of Controlled Trials, PubMed, and Embase databases were searched for English-language, human in vivo studies on the treatment of symptomatic knee osteoarthritis with intra-articular PRP compared with HA. The following keywords were used for the search: "platelet-rich plasma," "PRP," "platelet-rich fibrin," "PRF," "platelet," "plasma," "arthritis," "osteoarthritis," "gonarthrosis," and "degeneration...
June 19, 2018: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/29920972/physical-activity-intervention-in-primary-care-and-rheumatology-for-the-management-of-knee-osteoarthritis-a-review
#14
Esther Waugh, Lauren King, Natasha Gakhal, Gillian Hawker, Fiona Webster, Daniel White
Physical activity (PA) is recommended by osteoarthritis (OA) international organizations as an essential component of first-line management of knee OA. Primary care physicians (PCP) and rheumatologists can play a key role in promoting PA but the extent that PA recommendation is occurring in primary and rheumatology care is unclear. This review provides an overview of current practice of PCP- and rheumatology-delivered PA intervention in the United States, Canada and Europe for the management of knee OA and explores barriers to implementing PA intervention in primary and rheumatology care...
June 19, 2018: Arthritis Care & Research
https://www.readbyqxmd.com/read/29920331/preoperative-neuropathic-pain-like-symptoms-and-central-pain-mechanisms-in-knee-osteoarthritis-predicts-poor-outcome-6-months-after-total-knee-replacement-surgery
#15
Thomas Kurien, Lars Arendt-Nielsen, Kristian K Petersen, Thomas Graven-Nielsen, Brigitte E Scammell
Preoperative pain characteristics in osteoarthritis (OA) patients may explain persistent pain after total knee replacement (TKR). Fifty patients awaiting TKR and 22 asymptomatic controls were recruited to evaluate the degree of neuropathic pain symptoms and pain sensitisation. OA patients were pain phenotyped into two groups based on the PainDETECT questionnaire: High PainDETECT group (scores ≥19) indicating neuropathic pain-like symptoms, Low PainDETECT group (scores <19) indicating nociceptive or mixed pain...
June 16, 2018: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/29917216/expression-level-of-proteoglycan-collagen-and-type-ii-collagen-in-osteoarthritis-rat-model-is-promoted-and-degradation-of-cartilage-is-prevented-by-glucosamine-methyl-ester
#16
X-X Wang, L Cai
OBJECTIVE: In the current study, the effect of glucosamine methyl ester on cartilage degeneration in osteoarthritis rat model was investigated. MATERIALS AND METHODS: Forty Sprague-Dawley rats were assigned into 5 groups of 8 animals each. Osteoarthritis was induced in 4 groups using medial parapatellar incision followed by anterior cruciate ligament transection and meniscectomy. Normal and model osteoarthritis groups were given normal saline. The three treatment groups received 2, 5 and 10 mg/kg doses of glucosamine methyl ester daily for one month...
June 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29917139/structural-brain-alterations-before-and-after-total-knee-arthroplasty-a-longitudinal-assessment
#17
Gwyn N Lewis, Rosalind S Parker, Sheena Sharma, David A Rice, Peter J McNair
Objective: Many studies have provided evidence of altered brain structure in chronic pain conditions, as well as further adaptations following treatment that are coincident with changes in pain. Less is known regarding how these structural brain adaptations relate to assessments of nociceptive processing. The current study aimed to investigate brain structure in people with knee osteoarthritis (OA) before and after total knee arthroplasty (TKA) and to investigate the relationships between these findings and quantitative sensory testing (QST) of the nociceptive system...
June 15, 2018: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/29917100/conventional-and-biologic-disease-modifying-anti-rheumatic-drugs-for-osteoarthritis-a-meta-analysis-of-randomized-controlled-trials
#18
Monica S M Persson, Aliya Sarmanova, Michael Doherty, Weiya Zhang
Objectives: The role of inflammation in OA is controversial and it is unclear whether suppressing inflammation with conventional or biologic DMARDs is effective. A systematic review and meta-analysis of randomized controlled trials (RCTs) was conducted to compare DMARDs with placebo in participants with symptomatic OA. Methods: Databases (Medline, Embase, Allied and Complementary Medicine Database, Web of Science and Cochrane Library), conference abstracts and ClinicalTrials...
June 16, 2018: Rheumatology
https://www.readbyqxmd.com/read/29916929/intravenous-versus-topical-tranexamic-acid-in-total-knee-arthroplasty-both-effective-in-a-randomized-clinical-trial-of-640-patients
#19
Matthew P Abdel, Brian P Chalmers, Michael J Taunton, Mark W Pagnano, Robert T Trousdale, Rafael J Sierra, Yuo-Yu Lee, Friedrich Boettner, Edwin P Su, Steven B Haas, Mark P Figgie, David J Mayman
BACKGROUND: Tranexamic acid (TXA) reduces bleeding and the need for transfusion after total knee arthroplasty. Most literature has focused on intravenous (IV) administration of TXA, with less data available on the efficacy of topically administered TXA. This multicenter randomized clinical trial specifically assessed the efficacy of topical TXA compared with IV TXA as measured by calculated blood loss, drain output, and transfusion rates. Complications, including venous thromboembolism (VTE), were reported...
June 20, 2018: Journal of Bone and Joint Surgery. American Volume
https://www.readbyqxmd.com/read/29916191/racial-disparities-in-revision-total-knee-arthroplasty-analysis-of-125-901-patients-in-national-us-private-payer-database
#20
Martin Roche, Tsun Yee Law, Assem A Sultan, Erica Umpierrez, Anton Khlopas, Sam Rosas, Jennifer Kurowicki, Kevin Wang, Michael A Mont
INTRODUCTION: There is a relative paucity of studies that characterized racial disparities in revision total knee arthroplasty (TKA). Therefore, this study was specifically conducted to evaluate the following: (1) incidence; (2) annual burden; (3) causes; and (4) age group distribution of revision TKA among different racial groups in the US sample population. METHODS: The PearlDiver database was utilized to identify patients with knee osteoarthritis (OA) who underwent primary then subsequent revision TKA from January 2007 to December 2014...
June 18, 2018: Journal of Racial and Ethnic Health Disparities
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