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Osteoarthritis, Knee

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https://www.readbyqxmd.com/read/28645132/platelet-rich-plasma-for-the-treatment-of-knee-osteoarthritis-a-review
#1
Nicolas S Piuzzi, Morad Chughtai, Anton Khlopas, Steven F Harwin, Anthony Miniaci, Michael A Mont, George F Muschler
No abstract text is available yet for this article.
June 23, 2017: Journal of Knee Surgery
https://www.readbyqxmd.com/read/28644677/young-athletes-after-anterior-cruciate-ligament-reconstruction-with-single-leg-landing-asymmetries-at-the-time-of-return-to-sport-demonstrate-decreased-knee-function-2-years-later
#2
Matthew P Ithurburn, Mark V Paterno, Kevin R Ford, Timothy E Hewett, Laura C Schmitt
BACKGROUND: Previous work shows that young athletes after anterior cruciate ligament reconstruction (ACLR) demonstrate single-leg (SL) landing movement asymmetries at the time of return to sport (RTS); however, the effect of movement asymmetries on longitudinal knee-related function after ACLR has not been examined. Hypothesis/Purpose: The purpose of this study was to examine the effect of SL drop-landing movement symmetry at the time of RTS on knee-related function 2 years later in young athletes after ACLR...
June 1, 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/28642979/-medial-opening-wedge-high-tibial-osteotomy
#3
REVIEW
P Niemeyer, A Stöhr, M Köhne, A Hochrein
OBJECTIVE: Reduction of the load to the medial compartment in patients with medial knee osteoarthritis and varus malalignment. Unloading of the posterolateral complex in varus deformity with complex ligamentous laxity. INDICATIONS: Medial knee osteoarthritis and varus malalignment with largely intact lateral and patellofemoral joint aspect. Complex ligament insufficiency combined with varus deformity. CONTRAINDICATIONS: Substantially impaired range of motion...
June 22, 2017: Operative Orthopädie und Traumatologie
https://www.readbyqxmd.com/read/28642646/intensity-duration-and-type-of-physical-activity-required-to-improve-function-in-knee-osteoarthritis
#4
Ricardo Akihiro Kirihara, Fellipe Bravim Catelan, Fabiane Elize Sabino DE Farias, Cleidnéia Aparecida Clemente DA Silva, Claudia Helena DE Azevedo Cernigoy, Márcia Uchoa DE Rezende
OBJECTIVE: To evaluate the effects of physical activity intensity, type and duration in patients with knee osteoarthritis (KOA) . METHODS: A retrospective study of 195 KOA patients who were followed for two years after receiving educational material about KOA with or without attending classes. The patients were evaluated at baseline and 24 months. At the evaluations, the patients answered questionnaires pertaining to pain and function (WOMAC, Lequesne, VAS and SF-36); reported the intensity, duration and type of exercise performed per week; and performed the Timed Up & Go (TUG) and Five Times Sit-to-Stand (FTSST) tests ...
January 2017: Acta Ortopedica Brasileira
https://www.readbyqxmd.com/read/28642645/parqve-project-arthritis-recovering-quality-of-life-through-education-two-year-results
#5
Márcia Uchoa DE Rezende, Renato Frucchi, Alexandre Felício Pailo, Gustavo Constantino DE Campos, Thiago Pasqualin, Marcelo Issao Hissadomi
OBJECTIVE: To evaluate the effects of a multi-professional educational program in patients with knee osteoarthritis (KOA) . METHODS: Prospective randomized controlled trial with 195 KOA patients. One group was submitted to two-day lectures and received educational material about KOA (Class group), and the control group received the educational material only. Patients were evaluated at baseline, twelve and 24 months. At evaluation, patients answered pain and functional questionnaires (WOMAC, Lequesne, VAS and SF-36); reported the intensity of exercise per week; measured the body fat percentage, weight and height to estimate body mass index (BMI); and performed Timed Up & Go (TUG) and Five-Times-Sit-to-Stand (FTSST) tests ...
January 2017: Acta Ortopedica Brasileira
https://www.readbyqxmd.com/read/28642490/relationship-between-kellgren-lawrence-score-and-3d-kinematic-gait-analysis-of-patients-with-medial-knee-osteoarthritis-using-a-new-gait-system
#6
Xiaolong Zeng, Limin Ma, Zefeng Lin, Wenhan Huang, Zhiqiang Huang, Yu Zhang, Chuanbin Mao
Knee osteoarthritis (KOA) is reported to have characteristic kinematics during walking. However, the relationship between Kellgren-Lawrence (K/L) score and the 3D kinematic gait of patients with medial KOA remains unclear. Here, ninety-seven patients with medial KOA and thirty-eight asymptomatic participants were involved. Patients with medial KOA were divided into early, moderate, and severe KOA based on the K/L score. Through kinematic gait analysis, we found a relationship between K/L score and 3D kinematic gait for patients...
June 22, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28642164/joint-loading-and-proximal-tibia-subchondral-trabecular-bone-microarchitecture-differ-with-walking-gait-patterns-in-end-stage-knee-osteoarthritis
#7
Bryant C Roberts, Lucian B Solomon, Graham Mercer, Karen J Reynolds, Dominic Thewlis, Egon Perilli
OBJECTIVES: To (1) stratify subgroups according to their distinct walking gait patterns in end-stage knee osteoarthritis (OA) patients; (2) compare measures of joint loading and proximal tibia subchondral trabecular bone (STB) microarchitecture among subgroups. DESIGN: Twenty-five knee OA patients undergoing total knee arthroplasty had pre-operative gait analysis. Following surgery, excised tibial plateaus were micro-CT-scanned and STB microarchitecture analysed in four tibial condylar regions of interest...
June 19, 2017: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/28640896/beneficial-effects-of-a-gait-used-while-wearing-a-kimono-to-decrease-the-knee-adduction-moment-in-healthy-adults
#8
Susumu Ota, Yukari Ogawa, Hiroki Ota, Tomoya Fujiwara, Tadashi Sugiyama, Akira Ochi
The knee adduction moment (KAM) relates to medial knee osteoarthritis (OA). Several gait modifications to reduce the KAM for the prevention of knee OA have been studied. Most of the modifications, however, involve voluntary changes in leg alignment. Here we investigated the biomechanical effects for reducing the KAM of a walking style with a small trunk rotation and arm swing gait, which is a natural walking style used while wearing a kimono (Nanba walk) that shifts the ground reaction force toward the stance leg (reduced lever arm)...
2017: PloS One
https://www.readbyqxmd.com/read/28640163/mistletoe-fig-ficus-deltoidea-jack-leaf-extract-prevented-postmenopausal-osteoarthritis-by-attenuating-inflammation-and-cartilage-degradation-in-rat-model
#9
Nur Adeelah Che Ahmad Tantowi, Paisal Hussin, Seng Fong Lau, Suhaila Mohamed
OBJECTIVE: Ficus deltoidea Jack (mistletoe fig) is an ornamental plant found in various parts of the world and used as traditional herbal medicine in some countries. This study investigated the potential use of F deltoidea leaf extract to mitigate osteoarthritis (OA) in ovariectomized (estrogen-deficient postmenopausal model) rats and the mechanisms involved. Diclofenac was used for comparison. METHODS: Sprague-Dawley female rats (12 weeks old) were divided randomly into five groups (n = 6): healthy; nontreated OA; OA + diclofenac (5 mg/kg); OA + extract (200 mg/kg); and OA + extract (400 mg/kg)...
June 19, 2017: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/28639519/knee-joint-kinetics-in-response-to-multiple-three-dimensional-printed-customised-foot-orthoses-for-the-treatment-of-medial-compartment-knee-osteoarthritis
#10
Richard Allan, James Woodburn, Scott Telfer, Mandy Abbott, Martijn Pm Steultjens
The knee adduction moment is consistently used as a surrogate measure of medial compartment loading. Foot orthoses are designed to reduce knee adduction moment via lateral wedging. The 'dose' of wedging required to optimally unload the affected compartment is unknown and variable between individuals. This study explores a personalised approach via three-dimensional printed foot orthotics to assess the biomechanical response when two design variables are altered: orthotic length and lateral wedging. Foot orthoses were created for 10 individuals with symptomatic medial knee osteoarthritis and 10 controls...
June 2017: Proceedings of the Institution of Mechanical Engineers. Part H, Journal of Engineering in Medicine
https://www.readbyqxmd.com/read/28639008/evaluation-of-running-knotless-barbed-suture-for-capsular-closure-in-primary-total-knee-arthroplasty-for-osteoarthritis-a-prospective-randomized-study
#11
Rajesh Malhotra, Vaibhav Jain, Vijay Kumar, Deepak Gautam
AIMS: This study was conducted to compare the barbed vs. traditional suture technique in capsular closure of total knee arthroplasty in terms of closure time, cost, needle prick injury, post-operative complication, blood loss and post-operative function. PATIENTS AND METHODS: Eighty patients in a barbed suture group and 90 in a traditional group were enrolled in this prospective randomized study. RESULTS: Barbed suture was associated with 4...
June 21, 2017: International Orthopaedics
https://www.readbyqxmd.com/read/28638681/efficacy-of-extracorporeal-shockwave-therapy-and-low-intensity-pulsed-ultrasound-in-a-rat-knee-osteoarthritis-model-a-randomized-controlled-trial
#12
Volkan Yılmaz, Ömer Karadaş, Taner Dandinoğlu, Ebru Umay, Aytül Çakçı, Arif Kenan Tan
OBJECTIVE: This study aims to assess the efficacy of extracorporeal shockwave therapy (ESWT) and low-intensity pulsed ultrasound (LIPUS) on osteoarthritic rat knees. MATERIAL AND METHODS: Twenty-four rats were divided into 3 groups: group 1-control (n=8), group 2-LIPUS (n=8) and group 3-ESWT (n=8). Cartilage degeneration was provided using mono-iodo-asetate (MIA). One milligram of MIA was delivered to the right knees in group 1 and both knees in group 2 and 3. A 0...
June 2017: European Journal of Rheumatology
https://www.readbyqxmd.com/read/28638680/genetic-influence-of-growth-and-differentiation-factor-5-gene-polymorphism-104t-c-on-the-development-of-knee-osteoarthritis-and-its-association-with-disease-severity
#13
Mervat I Abd Elazeem, Enas Abolkheir Abdelaleem, Rabab A Mohamed
OBJECTIVE: The growth and differentiation factor 5 (GDF5) gene is recognized for its role in the development, repair, and maintenance of cartilage and bone. The present case-control study was conducted to detect the genetic association between GDF5 (+104T/C) single-nucleotide polymorphism (SNP) and primary knee osteoarthritis (KOA), as well as the possible association of SNP with the severity of KOA. MATERIAL AND METHODS: The study included 50 patients with primary KOA and 50 healthy control subjects...
June 2017: European Journal of Rheumatology
https://www.readbyqxmd.com/read/28638679/decrease-of-serum-biomarker-of-type-ii-collagen-degradation-coll2-1-by-intra-articular-injection-of-an-autologous-plasma-rich-platelet-in-patients-with-unilateral-primary-knee-osteoarthritis
#14
Rasha Mohamed Fawzy, Nashwa Ismail Hashaad, Amira Ibrahim Mansour
OBJECTIVE: This study aimed to evaluate the effect of one dose of intra-articular injection of (PRP) in the knee joint on a specific osteoarthritis (OA) serum biomarker of cartilage degeneration, Collagen 2-1 (Coll2-1), over a short period of 3 months. The aim extended to clarify the effect of PRP on the functional status of the osteoarthritic knee joint. MATERIAL AND METHODS: Sixty patients with primary unilateral knee OA were enrolled in this study. They were subdivided according to Kellgren-Lawrence grading scale (KL) into (Group I): including patients with KL grade < 3 and (Group II): including patients with KL grade ≥3...
June 2017: European Journal of Rheumatology
https://www.readbyqxmd.com/read/28638676/utilization-of-longitudinal-ultrasound-to-quantify-joint-soft-tissue-changes-in-a-mouse-model-of-posttraumatic-osteoarthritis
#15
Hao Xu, Echoe M Bouta, Ronald W Wood, Edward M Schwarz, Yongjun Wang, Lianping Xing
To assess the utility of longitudinal ultrasound (US) to quantify volumetric changes in joint soft tissues during the progression of posttraumatic osteoarthritis (PTOA) in mice, and validate the US results with histological findings. A longitudinal cohort of 3-month-old wild-type C57BL/6 male mice received the Hulth-Telhag surgical procedure on right knee to induce PTOA, and sham surgery on their left knee as control. US scans were performed on both knees before, 2, 4, 6, and 8 weeks post-surgery. Joint space volume and Power-Doppler (PD) volume were obtained from US images via Amira software...
2017: Bone Research
https://www.readbyqxmd.com/read/28638242/cost-utility-of-a-single-injection-combined-corticosteroid-hyaluronic-acid-formulation-vs-a-2-injection-regimen-of-sequential-corticosteroid-and-hyaluronic-acid-injections
#16
Etienne L Belzile, Robert T Deakon, Christopher Vannabouathong, Mohit Bhandari, Martin Lamontagne, Robert McCormack
Research has shown early and sustained relief with a combination therapy of a corticosteroid (CS) and hyaluronic acid (HA) in knee osteoarthritis (OA) patients. This can be administered via a single injection containing both products or as separate injections. The former may be more expensive when considering only product cost, but the latter incurs the additional costs and time of a second procedure. The purpose of this study was to compare the cost-utility of the single injection with the 2-injection regimen...
2017: Clinical Medicine Insights. Arthritis and Musculoskeletal Disorders
https://www.readbyqxmd.com/read/28637509/genetic-effects-of-rs3740199-polymorphism-in-adam12-gene-on-knee-osteoarthritis-a-meta-analysis
#17
Zheng Hao, Xin Li, Jin Dai, Baocheng Zhao, Qing Jiang
BACKGROUND: Knee osteoarthritis (OA) is a complex arthritic condition in which genetic factors play an important role. ADAM12 gene is one of the recognized candidate genes although the results are conflicting. To derive a more precise estimation of the association between rs3740199 polymorphism in ADAM12 gene and risk of knee OA, we performed a meta-analysis based on six related studies, including a total of 2185 cases and 3716 controls. METHODS: A comprehensive search was performed to identify related studies up to April 14, 2017...
June 20, 2017: Journal of Orthopaedic Surgery and Research
https://www.readbyqxmd.com/read/28636254/pirfenidone-reduces-subchondral-bone-loss-and-fibrosis-after-murine-knee-cartilage-injury
#18
Deva D Chan, Jun Li, Wei Luo, Dan N Predescu, Brian J Cole, Anna Plaas
Pirfenidone is an anti-inflammatory and anti-fibrotic drug that has shown efficacy in lung and kidney fibrosis. Because inflammation and fibrosis have been linked to the progression of osteoarthritis, we investigated the effects of oral Pirfenidone in a mouse model of cartilage injury, which results in chronic inflammation and joint-wide fibrosis in mice that lack hyaluronan synthase 1 (Has1(-/-) ) in comparison to wild-type. Femoral cartilage was surgically injured in wild-type and Has1(-/-) mice, and Pirfenidone was administered in food starting after 3 days...
June 21, 2017: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/28634785/-imaging-and-preoperative-planning-for-osteotomies-around-the-knee
#19
REVIEW
D Pape, A Hoffmann, R Seil
Physiologic alignment of the human lower leg is well defined. The etiology for malalignment comprises constitutional, degenerative and posttraumatic conditions. Osteotomies around the knee can correct the malalignment, provided that the origin of deviation is in proximity of the knee center. Crucial factors for the evaluation of axis deviation are the weight-bearing line, the mechanical axes of femur and tibia, the joint line angles and the center of the hip, knee and upper ankle joint. Careful preoperative planning is mandatory for reproducible clinical results...
June 20, 2017: Operative Orthopädie und Traumatologie
https://www.readbyqxmd.com/read/28634540/improvement-of-walking-ability-during-postoperative-rehabilitation-with-the-hybrid-assistive-limb-after-total-knee-arthroplasty-a-randomized-controlled-study
#20
Yohei Tanaka, Hiroyuki Oka, Shuichi Nakayama, Takaaki Ueno, Ko Matsudaira, Toshiki Miura, Kiyokazu Tanaka, Sakae Tanaka
OBJECTIVE: We aimed to compare the efficacies of rehabilitation with the hybrid assistive limb and conventional rehabilitation after total knee arthroplasty. MATERIALS AND METHODS: A total of 37 consecutive patients who underwent primary total knee arthroplasty for knee osteoarthritis were enrolled. Seven patients withdrew from the study after randomization, and 30 patients (hybrid assistive limb group: n = 16; conventional group: n = 14) completed the randomized controlled trial...
2017: SAGE Open Medicine
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