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Flat wart

Joanna Przybyszewska, Abraham Zlotogorski, Yuval Ramot
Epidermodysplasia verruciformis (EV) is a rare genodermatosis characterized by abnormal susceptibility to cutaneous human beta-papillomavirus infections causing persistent flat warts or pityriasis versicolor-like lesions. This generalized verrucous skin disorder resembles generalized verrucosis, but these 2 conditions are distinguished by differences in clinical manifestation and the human papillomavirus types involved. A breakthrough in our understanding of EV was the discovery that homozygous inactivating mutations in TMC6 (EVER1) and TMC8 (EVER2) determine susceptibility to this disorder; however, they have not solved all EV cases fully...
February 10, 2017: Journal of the American Academy of Dermatology
Zhiyong Yuan, Yunke Wu, Jiajun Zhou, Jing Che
New amphibian species have been constantly discovered throughout southern China, including from areas close to heavily populated cities that remain poorly surveyed for amphibian diversity. We describe a new species of the newt genus Paramesotriton from Fujian, a developed province on the southeastern coast of mainland China. The mitochondrial genealogy suggests that the new species is the sister taxon to Paramesotriton hongkongensis, separated by an uncorrected pairwise distances of 5.8% at the ND2 gene fragment analyzed...
December 12, 2016: Zootaxa
Alexandru Oanţă, Marius Irimie
In the last twenty years, the prevalence of individuals with tattoos in the general population has increased in Europe (1) as well as in Australia (2) and the United States of America (3). A series of complications such as acute inflammatory reactions, allergic contact dermatitis (4,5), photoinduced, lichenoid, and granulomatous reactions (6, 7), pseudolymphoma (8), pseudoepitheliomatous hyperplasia (9), skin infections (6), and skin cancers (10) may occur on tattoos. Infectious complications on tattoos include bacterial infections (pyoderma, leprosy, syphilis, cutaneous tuberculosis, mycobacteriosis) (11-14), viral infections (molluscum contagiosum, warts, herpes simplex, hepatitis B and C) (15-17), and fungal infections (sporotrichosis, dermatophytosis) (18,19)...
August 2016: Acta Dermatovenerologica Croatica: ADC
Nestor Fernandez, Pieter Theron
Two new species of oribatid mites, Plasmobates zarae sp. n. and Basilobelba spasmenosi sp. n. are described from the Republic of Rwanda. They can easily be differentiated from other species by a number of characters. Plasmobates zarae sp. n. is differentiated the following characters. four types of particular cerotegumental layers. Integument slightly foveate to smooth on prodorsum; foveate on notogaster; ventral region rugose to smooth.Large rostral setae inserted on protuberance, whip-shaped, with longitudinal pucker; interlamellar setae rod-shaped with triangular scales; interlamellar setae small...
2016: ZooKeys
E L Maranda, V M Lim, A H Nguyen, K Nouri
Facial verruca plana, or flat warts, are benign skin papillomas caused by human papillomavirus infections. A large portion of cases are refractory to treatment and can cause psychosocial distress in patients. Laser and light modalities offer an alternative therapeutic approach that has not been extensively explored. We systematically reviewed PubMed for studies describing treatment of facial verruca plana using lasers, photodynamic therapy and infrared coagulation. Final inclusion and review of eighteen studies suggests laser and light therapies to have considerable potential in the treatment of this recalcitrant condition...
October 2016: Journal of the European Academy of Dermatology and Venereology: JEADV
Ya-Li Yang, Junjun Sang, Ning-Xin Liao, Fang Wei, Wanqin Liao, Jiang-Han Chen
The facial flat wart (verruca plana) is one of the most common reasons for dermatology and primary care visits. Although there are many therapeutic modalities, no single therapy has been proven to be completely curative. Case reports and uncontrolled studies suggested that photodynamic therapy (PDT) with topical 5-aminolevulinic acid (ALA) can effectively treat recalcitrant facial flat warts. A total of 12 patients with recalcitrant facial flat warts were enrolled in the study. ALA gel (10 %) was applied topically to lesions and incubated for 3 h...
July 2016: Lasers in Medical Science
James Q Del Rosso, Nanette Silverberg, Joshua A Zeichner
Acne vulgaris (AV) is considered a straightforward diagnosis made clinically without specific diagnostic testing. However, certain disorders may simulate AV, such as multiple small epidermal cysts or deep milia, multiple osteoma cutis, multiple small adnexal neoplasms, and follicular and/or infections characterized by multiple small papules and/or pustules such as gram-positive folliculitis, gram-negative folliculitis, Malassezia folliculitis, keratosis pilaris, and flat warts. This can lead to an erroneous diagnosis and improper management...
April 2016: Dermatologic Clinics
Jing Gao, Changbing Shen, Randy Ko, Xiadong Zheng, Zhongying Wang, Shengxiu Liu, Yongjiang Li, Mingjun Tang, Weiwei Yin, Chunjun Yang, Xuejun Zhang
No abstract text is available yet for this article.
2016: Journal of Cosmetic and Laser Therapy: Official Publication of the European Society for Laser Dermatology
Nidhi Patel, Nilofar Diwan, Pragya A Nair
Acrokeratosis verruciformis (AKV) of Hopf is an autosomal dominant genodermatosis with unknown etiology. It is characterized by multiple flat-topped keratotic papules resembling planar warts located mainly on the dorsum of hands and feet. Superficial ablation is the treatment of choice. A 41-year-old female presented with multiple hyperpigmented, hyperkeratotic papules and plaques over flexor aspect of both forearms, extensors of both legs and dorsum of the feet. Histopathology showed changes of AKV. Patient was treated with a combination of topical corticosteroids and cryotherapy with no visible improvement...
March 2015: Indian Dermatology Online Journal
Jonathan B Karnes, Richard P Usatine
Genital warts affect 1% of the sexually active U.S. population and are commonly seen in primary care. Human papillomavirus types 6 and 11 are responsible for most genital warts. Warts vary from small, flat-topped papules to large, cauliflower-like lesions on the anogenital mucosa and surrounding skin. Diagnosis is clinical, but atypical lesions should be confirmed by histology. Treatments may be applied by patients, or by a clinician in the office. Patient-applied treatments include topical imiquimod, podofilox, and sinecatechins, whereas clinician-applied treatments include podophyllin, bichloroacetic acid, and trichloroacetic acid...
September 1, 2014: American Family Physician
Ge Qian, Sisi Wang, Danqi Deng, Gaoyun Yang
Facial flat wart, caused by human papilloma virus type 3 and less often, type 10, 27, and 41, often brings many cosmetic problems to children and young adults. Considering the disturbing cosmetic problem, the treatment of facial flat wart is always frustrating and often unsuccessful, although there are many treatment modalities. Considering the possible serious side effects of 5-aminolevulinic acid photodynamic therapy (ALA-PDT), we designed step-up therapy of ALA-PDT on different clinical phases of facial flat wart...
March 2014: Dermatologic Therapy
Philipp Tschandl, Cliff Rosendahl, Harald Kittler
Keratinocytes react to human papillomavirus (HPV) infection by proliferation resulting in different clinical manifestations ranging from flat warts to common warts and cauliflower-like or filiform warts. The clinical presentation may vary according to the HPV type and anatomical site. Although warts are usually a self-limiting disease, some HPV subtypes may induce malignant changes. Bowenoid papulosis is characterized by multiple flat macules or patches in the genital area that may or may not be pigmented. Rarely other forms of superficial squamous cell carcinomas may be induced by HPV infections, for example periungual Bowen's disease...
2014: Current Problems in Dermatology
María Guadalupe Olguin-García, Fermín Jurado-Santa Cruz, María Luisa Peralta-Pedrero, Martha Alejandra Morales-Sánchez
UNLABELLED: Abstract Background: Recalcitrant facial flat warts are caused by human papillomavirus and may persist for years despite treatment. Isotretinoin has demonstrated benefits in the treatment of recalcitrant, genital and common warts, but placebo-controlled trials have not been performed. OBJECTIVE: To determine whether isotretinoin is safe and effective for recalcitrant facial flat warts. METHODS: Isotretinoin 30 mg/day or placebo was administered to 16 and 15 patients, respectively, in double-blind, randomized fashion for 12 weeks...
February 2015: Journal of Dermatological Treatment
E Grillo, P Boixeda, A Ballester, A Miguel-Morrondo, T Truchuelo, P Jaén
The facial flat wart is not only a contagious viral disease, but also a cause of a distressing cosmetic problem. Although there are many therapeutic options, including salicylic acid, imiquimod, cryotherapy, retinoids, intralesional immunotherapy, and topical 5-aminolevulinic acid photodynamic therapy among others, no monotherapy has been proved to achieve complete remission in every case. Treatment with pulsed dye laser (PDL) seems to be a promising therapeutic option. To assess the efficacy and safety of PDL in a series of patients with viral flat warts on the face, in this prospective study, 32 patients were treated with PDL at 595-nm wavelength, a laser energy density of 9 or 14 J/cm(2) with a spot size of 7 or 5 mm, respectively, with air cooling and a pulse duration of 0...
January 2014: Dermatologic Therapy
Charles Lynde, Ronald Vender, Marc Bourcier, Neal Bhatia
External genital warts (EGWs) are a common sexually transmitted infection caused by the human papillomavirus (HPV). Although over 100 HPV types have been identified, some of which are associated with cancer, EGWs are caused by noncancerous HPV subtypes 6 and 11. This cutaneous manifestation of HPV infection can be asymptomatic or produce warty lesions that may assume a cauliflower-like, flat, papular, or keratotic appearance. Physical symptoms may also accompany warts, such as pruritus, burning, pain, and obstruction...
December 2013: Journal of Cutaneous Medicine and Surgery
Tsuyoshi Mitsuishi, Ikuroh Ohsawa, Toshihiko Kato, Nagayasu Egawa, Tohru Kiyono
[This corrects the article on p. e79592 in vol. 8.].
2013: PloS One
Maria Giannaki, Talia Kakourou, Maria Theodoridou, Vassiliki Syriopoulou, Marios Kabouris, Eirini Louizou, George Chrousos
The human papillomavirus (HPV) infects the squamous epithelium of the skin and produces common warts, plantar warts, and flat warts, which occur commonly on the hands, face, and feet. The objective of this study was to determine the presence of HPV in warts in children in order to associate the virus with the disease. Sixty-eight children with clinically diagnosed cutaneous warts were recruited. Skin biopsy samples were examined and DNA was extracted using a commercially available kit. To distinguish between the HPV types, we used a specific pair of primers to amplify the HPV DNA...
November 2013: Pediatric Dermatology
Tsuyoshi Mitsuishi, Ikuroh Ohsawa, Toshihiko Kato, Nagayasu Egawa, Tohru Kiyono
More than 150 types of Human papillomaviruses (HPVs) have been isolated from numerous cutaneous and/or mucosal lesions. Flat wart samples on the face from 36 immunocompetent patients were collected and screened for HPV. From one sample, we cloned a putative novel genotype. The novel type consisted of 7779 bp in length with a GC content of 47.1%, containing open reading frames for putative early proteins (E1, E2, E4, E6, and E7) and two late proteins (L1 and L2). Homology searches and phylogenetic analyses indicated that it belonged to Alphapapillomavirus (Alpha-PV) species 2 and most closely resembled HPV 3...
2013: PloS One
Amir Zahir, Lauren Craig, Peter Rady, Stephen Tyring, Alison Ehrlich
Epidermodysplasia verruciformis (EV) is a rare, inherited dermatologic condition demonstrating an increased susceptibility to specific HPV genotypes, resulting in both benign and malignant skin lesions. Epidermodysplasia verruciformis lesions are frequently described as pityriasis versicolor-like scaly macules, flat wart-like papules, or verrucous and seborrhic keratosis-like papules and plaques. Acquired EV has been described in patients with HIV and in those who are on immunosuppressive therapy. We discuss a patient with congenital EV who presents with skin lesions associated with HPV 10, a less frequently cited causative subtype, and histological findings that are not classic for EV...
2013: Dermatology Online Journal
Karl Ulrich Petry, Alexander Luyten, Annika Justus, Angelika Iftner, Sarah Strehlke, Renate Schulze-Rath, Thomas Iftner
BACKGROUND: Wolfsburg HPV Epidemiological Study (WOLVES) is a population-based cohort study on HPV infections and associated diseases in the pre-vaccination era in young women in Wolfsburg, Germany. METHODS: Women born 1983/84 or 1988/89 were invited to participate. Participants were recruited in gynecology practices, and completed a questionnaire with socioeconomic, sexual and medical data including vaccination status. Pelvic examination with Pap smear and HPV testing (HC2 = Hybrid Capture 2) was obligatory...
2012: BMC Infectious Diseases
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