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Dorsal striatum

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https://www.readbyqxmd.com/read/27924300/a-dataset-of-multiresolution-functional-brain-parcellations-in-an-elderly-population-with-no-or-mild-cognitive-impairment
#1
Angela Tam, Christian Dansereau, AmanPreet Badhwar, Pierre Orban, Sylvie Belleville, Howard Chertkow, Alain Dagher, Alexandru Hanganu, Oury Monchi, Pedro Rosa-Neto, Amir Shmuel, John Breitner, Pierre Bellec
We present group eight resolutions of brain parcellations for clusters generated from resting-state functional magnetic resonance images for 99 cognitively normal elderly persons and 129 patients with mild cognitive impairment, pooled from four independent datasets. This dataset was generated as part of the following study: Common Effects of Amnestic Mild Cognitive Impairment on Resting-State Connectivity Across Four Independent Studies (Tam et al., 2015) [1]. The brain parcellations have been registered to both symmetric and asymmetric MNI brain templates and generated using a method called bootstrap analysis of stable clusters (BASC) (Bellec et al...
December 2016: Data in Brief
https://www.readbyqxmd.com/read/27921067/parallel-pathways-from-whisker-and-visual-sensory-cortices-to-distinct-frontal-regions-of-mouse-neocortex
#2
Varun Sreenivasan, Alexandros Kyriakatos, Celine Mateo, Dieter Jaeger, Carl C H Petersen
The spatial organization of mouse frontal cortex is poorly understood. Here, we used voltage-sensitive dye to image electrical activity in the dorsal cortex of awake head-restrained mice. Whisker-deflection evoked the earliest sensory response in a localized region of primary somatosensory cortex and visual stimulation evoked the earliest responses in a localized region of primary visual cortex. Over the next milliseconds, the initial sensory response spread within the respective primary sensory cortex and into the surrounding higher order sensory cortices...
July 2017: Neurophotonics
https://www.readbyqxmd.com/read/27920666/circuits-regulating-pleasure-and-happiness-the-evolution-of-the-amygdalar-hippocampal-habenular-connectivity-in-vertebrates
#3
Anton J M Loonen, Svetlana A Ivanova
Appetitive-searching (reward-seeking) and distress-avoiding (misery-fleeing) behavior are essential for all free moving animals to stay alive and to have offspring. Therefore, even the oldest ocean-dwelling animal creatures, living about 560 million years ago and human ancestors, must have been capable of generating these behaviors. The current article describes the evolution of the forebrain with special reference to the development of the misery-fleeing system. Although, the earliest vertebrate ancestor already possessed a dorsal pallium, which corresponds to the human neocortex, the structure and function of the neocortex was acquired quite recently within the mammalian evolutionary line...
2016: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/27919729/noradrenergic-modulation-of-evoked-dopamine-release-and-ph-shift-in-the-mouse-dorsal-hippocampus-and-ventral-striatum
#4
Adam Z Weitemier, Thomas J McHugh
Rapid monoamine release in the dorsal hippocampus is not well characterized, despite its postulated role in modulating fast hippocampal circuit dynamics. We measured monoamine release in the dorsal hippocampus upon stimulation of the ventral tegmental area (VTA) with fast-scan cyclic voltammetry in anesthetized norepinephrine-depleted and non-depleted mice. Within the hippocampus, norepinephrine depletion altered the ability of α2 adrenergic compounds and transporter blockers to modulate the small, evoked monoamine signal...
December 2, 2016: Brain Research
https://www.readbyqxmd.com/read/27909683/fronto-striatal-glutamate-in-children-with-tourette-s-disorder-and-attention-deficit-hyperactivity-disorder
#5
Jilly Naaijen, Natalie J Forde, David J Lythgoe, Sophie E A Akkermans, Thaira J C Openneer, Andrea Dietrich, Marcel P Zwiers, Pieter J Hoekstra, Jan K Buitelaar
OBJECTIVE: Both Tourette's disorder (TD) and attention-deficit/hyperactivity disorder (ADHD) have been related to abnormalities in glutamatergic neurochemistry in the fronto-striatal circuitry. TD and ADHD often co-occur and the neural underpinnings of this co-occurrence have been insufficiently investigated in prior studies. METHOD: We used proton magnetic resonance spectroscopy (1H-MRS) in children between 8 and 12 years of age (TD n = 15, ADHD n = 39, TD + ADHD n = 29, and healthy controls n = 53) as an in vivo method of evaluating glutamate concentrations in the fronto-striatal circuit...
2017: NeuroImage: Clinical
https://www.readbyqxmd.com/read/27895606/being-in-a-romantic-relationship-is-associated-with-reduced-gray-matter-density-in-striatum-and-increased-subjective-happiness
#6
Hiroaki Kawamichi, Sho K Sugawara, Yuki H Hamano, Kai Makita, Masahiro Matsunaga, Hiroki C Tanabe, Yuichi Ogino, Shigeru Saito, Norihiro Sadato
Romantic relationship, a widespread feature of human society, is one of the most influential factors in daily life. Although stimuli related to romantic love or being in a romantic relationship commonly result in enhancement of activation or functional connectivity of the reward system, including the striatum, the structure underlying romantic relationship-related regions remain unclear. Because individual experiences can alter gray matter within the adult human brain, we hypothesized that romantic relationship is associated with structural differences in the striatum related to the positive subjective experience of being in a romantic relationship...
2016: Frontiers in Psychology
https://www.readbyqxmd.com/read/27890744/gene-expression-of-pro-opiomelanocortin-and-melanocortin-receptors-is-regulated-in-the-hypothalamus-and-mesocorticolimbic-system-following-nicotine-administration
#7
Damla E Tapinc, Rabia Ilgin, Egemen Kaya, Oguz Gozen, Muzeyyen Ugur, Ersin O Koylu, Lutfiye Kanit, Aysegul Keser, Burcu Balkan
Pro-opiomelanocortin (POMC)-derived peptides and their receptors have been shown to play important roles in natural and drug-induced reward and reinforcement. Reward process may involve the regulation of POMC gene expression and the gene expression of POMC-derived peptide receptors. The present study investigated the alterations observed in the transcript levels of POMC, melanocortin 3 (MC3R), melanocortin 4 (MC4R) and mu-opioid receptors (MOR) in the hypothalamus and mesocorticolimbic system during nicotine exposure...
November 24, 2016: Neuroscience Letters
https://www.readbyqxmd.com/read/27889621/identifying-non-toxic-doses-of-manganese-for-manganese-enhanced-magnetic-resonance-imaging-to-map-brain-areas-activated-by-operant-behavior-in-trained-rats
#8
Rita Gálosi, Csaba Szalay, Mihály Aradi, Gábor Perlaki, József Pál, Roy Steier, László Lénárd, Zoltán Karádi
Manganese-enhanced magnetic resonance imaging (MEMRI) offers unique advantages such as studying brain activation in freely moving rats, but its usefulness has not been previously evaluated during operant behavior training. Manganese in a form of MnCl2, at a dose of 20mg/kg, was intraperitoneally infused. The administration was repeated and separated by 24h to reach the dose of 40mg/kg or 60mg/kg, respectively. Hepatotoxicity of the MnCl2 was evaluated by determining serum aspartate aminotransferase, alanine aminotransferase, total bilirubin, albumin and protein levels...
November 24, 2016: Magnetic Resonance Imaging
https://www.readbyqxmd.com/read/27887704/aberrant-modulation-of-brain-activation-by-emotional-valence-during-self-referential-processing-among-patients-with-delusions-of-reference
#9
Todd A Girard, Louis Lakatos, Mahesh Menon
BACKGROUND AND OBJECTIVES: Delusions of reference are thought to reflect abnormally heightened attributions of salience to mundane events or stimuli that lead to convictions that they are personally significant or directed at the observer. Recent findings highlight abnormal recruitment of brain regions associated with self-referential processes among patients with referential delusions. Given the inherent overlap of emotion, incentive salience, and self-relevance, as well as with aberrant thought processes in psychosis, this study investigated the implicit relations between participants' perception of the emotional valence of stimuli on neural correlates of self-referent judgments among schizophrenia-spectrum patients with referential delusions...
November 17, 2016: Journal of Behavior Therapy and Experimental Psychiatry
https://www.readbyqxmd.com/read/27878759/loss-of-adenylyl-cyclase-type-5-in-the-dorsal-striatum-produces-autistic-like-behaviors
#10
Hannah Kim, Yunjin Lee, Jin-Young Park, Ji-Eun Kim, Tae-Kyung Kim, Juli Choi, Jung-Eun Lee, Eun-Hwa Lee, Daesoo Kim, Kyoung-Shim Kim, Pyung-Lim Han
Autism spectrum disorders (ASDs) are a heterogeneous group of psychiatric illness characterized by common core symptoms including sociability deficits and stereotyped behaviors. ASD is caused by various genetic and non-genetic factors. The genetic effects of autism-related genes are usually global and are presented with multiple symptoms, which hamper understanding of the mechanism through which the diverse causes of ASD produce common symptoms. In the present study, we demonstrate that genetic or molecular disruption of an array of molecular networks centered on adenylyl cyclase type-5 (AC5 or ADCY5) in the dorsal striatum produces autistic-like behaviors...
November 23, 2016: Molecular Neurobiology
https://www.readbyqxmd.com/read/27872762/understanding-the-functional-plasticity-in-neural-networks-of-the-basal-ganglia-in-cocaine-use-disorder-a-role-for-allosteric-receptor-receptor-interactions-in-a2a-d2-heteroreceptor-complexes
#11
REVIEW
Dasiel O Borroto-Escuela, Karolina Wydra, Julia Pintsuk, Manuel Narvaez, Fidel Corrales, Magdalena Zaniewska, Luigi F Agnati, Rafael Franco, Sergio Tanganelli, Luca Ferraro, Malgorzata Filip, Kjell Fuxe
Our hypothesis is that allosteric receptor-receptor interactions in homo- and heteroreceptor complexes may form the molecular basis of learning and memory. This principle is illustrated by showing how cocaine abuse can alter the adenosine A2AR-dopamine D2R heterocomplexes and their receptor-receptor interactions and hereby induce neural plasticity in the basal ganglia. Studies with A2AR ligands using cocaine self-administration procedures indicate that antagonistic allosteric A2AR-D2R heterocomplexes of the ventral striatopallidal GABA antireward pathway play a significant role in reducing cocaine induced reward, motivation, and cocaine seeking...
2016: Neural Plasticity
https://www.readbyqxmd.com/read/27871824/cocaine-self-administration-extinction-training-and-drug-induced-relapse-change-metabotropic-glutamate-mglu5-receptors-expression-evidence-from-radioligand-binding-and-immunohistochemistry-assays
#12
Lucyna Pomierny-Chamiolo, Joanna Miszkiel, Malgorzata Frankowska, Beata Bystrowska, Malgorzata Filip
Several behavioral findings highlight the importanceof glutamatergic transmission and its metabotropic receptor type 5 (mGlu5) in the controlling of cocaine reward and seeking behaviors. The molecular or neurochemical nature of such interactions is not well recognized, so in the present paper we determine if cocaine self-administration and extinction/reinstatement models with the yoked triad control procedure alter mGlu5 receptor density in rats. [³H]MPEP was used to evaluate mGlu5 receptors density and affinity in selected brain structures, while immunofluorescence analysis was used to detect changes in mGlu5 receptors' brain location...
November 18, 2016: Brain Research
https://www.readbyqxmd.com/read/27871668/emerging-role-for-nucleus-accumbens-medium-spiny-neuron-subtypes-in-depression
#13
REVIEW
T Chase Francis, Mary Kay Lobo
The ventral striatum (nucleus accumbens) and its role in mood, reward, and motivation has been the focus of significant research. Despite this interest, little work has addressed cell type-specific distinctions in medium spiny neurons (MSNs), the main projection neurons in the nucleus accumbens and dorsal striatum, and their function in relation to stress and depression. Previous work has shown opposing roles for D1 and D2 receptor MSN subtypes in depression-like outcomes to stress, particularly in regard to repeated neuronal stimulation and excitatory transmission...
September 15, 2016: Biological Psychiatry
https://www.readbyqxmd.com/read/27870942/altered-time-course-of-amygdala-activation-during-speech-anticipation-in-social-anxiety-disorder
#14
Carolyn D Davies, Katherine Young, Jared B Torre, Lisa J Burklund, Philippe R Goldin, Lily A Brown, Andrea N Niles, Matthew D Lieberman, Michelle G Craske
BACKGROUND: Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). METHOD: Participants (SAD n=58; HC n=16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task...
November 16, 2016: Journal of Affective Disorders
https://www.readbyqxmd.com/read/27869141/fronto-striatal-glutamate-in-autism-spectrum-disorder-and-obsessive-compulsive-disorder
#15
Jilly Naaijen, Marcel P Zwiers, Houshang Amiri, Steven Cr Williams, Sarah Durston, Bob Oranje, Daniel Brandeis, Regina Boecker-Schlier, Matthias Ruf, Isabella Wolf, Tobias Banaschewski, Jeffrey C Glennon, Barbara Franke, Jan K Buitelaar, David J Lythgoe
Autism spectrum disorders (ASD) and obsessive compulsive disorder (OCD) are often comorbid with the overlap based on compulsive behaviors. Although previous studies suggest glutamatergic deficits in fronto-striatal brain areas in both disorders, this is the first study to directly compare the glutamate concentrations across the two disorders with those in healthy control participants using both categorical and dimensional approaches. In the current multi-center study (four centers), we used proton magnetic resonance spectroscopy (1H MRS) in 51 children with ASD, 29 with OCD, and 53 healthy controls (aged 8 to 13 years) to investigate glutamate (Glu) concentrations in two regions of the fronto-striatal circuit: midline anterior cingulate cortex (ACC) and left dorsal striatum...
November 21, 2016: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/27865452/cyp2a6-genetic-variation-alters-striatal-cingulate-circuits-network-hubs-and-executive-processing-in-smokers
#16
Sufang Li, Yihong Yang, Ewa Hoffmann, Rachel F Tyndale, Elliot A Stein
BACKGROUND: Variation in the CYP2A6 gene alters the rate of nicotine metabolic inactivation and is associated with smoking behaviors and cessation success rates. The underlying neurobiological mechanisms of this genetic influence are unknown. METHODS: Intrinsic functional connectivity strength, a whole-brain, data-driven, graph theory-based method, was applied to resting-state functional magnetic resonance imaging data in 66 smokers and 92 nonsmokers. A subset of subjects (n = 23/20; smokers/nonsmokers) performed the monetary incentive delay task, probing reward anticipation, and a go/no-go task, probing response inhibition, on two occasions, in the presence and absence of a nicotine patch...
September 28, 2016: Biological Psychiatry
https://www.readbyqxmd.com/read/27864853/pet-radiotracer-development-for-imaging-high-affinity-state-of-dopamine-d2-and-d3-receptors-binding-studies-of-fluorine-18-labeled-aminotetralins-in-rodents
#17
Jogeshwar Mukherjee, Divya Majji, Jasmeet Kaur, Cristian C Constantinescu, Tanjore K Narayanan, Bingzhi Shi, Mohamed T Nour, Min-Liang Pan
Imaging the high-affinity, functional state (HA) of dopamine D2 and D3 receptors has been pursued in PET imaging studies of various brain functions. We report further evaluation of (18) F-5-OH-FPPAT, and the newer (18) F-5-OH-FHXPAT and (18) F-7-OH-FHXPAT. Syntheses of (18) F-5-OH-FHXPAT and (18) F-7-OH-FHXPAT were improved by modifications of our previously reported procedures. Brain slices and brain homogenates from male Sprague-Dawley rats were used with the 3 radiotracers (74-111 kBq/cc). Competition with dopamine (1-100 nM) and Gpp(NH)p (10-50 µM) were carried out to demonstrate binding to dopamine D2 and D3 HA-states and binding kinetics of (18) F-5-OH-FPPAT measured...
November 19, 2016: Synapse
https://www.readbyqxmd.com/read/27863709/the-neuronal-basis-of-copper-induced-modulation-of-anxiety-state-in-rat
#18
Abbaoui Abdellatif, E L Hiba Omar, Gamrani Halima
Recently, studies have provided strong evidence indicating the involvement of trace elements in the physiopathology of psychiatric disorders, particularly anxiety. We aimed, through the present study, to describe the effect of acute exposure to Cu (10mg/kg BW) on anxiety state together with the serotoninergic and dopaminergic systems in rat by means of neurobehavioral tests (elevated plus maze, dark light box) and immunohistochemistry using anti-serotonin (5HT) and anti-tyrosine hydroxylase (TH). Our data report that Cu enhanced 5HT innervation in the dorsal raphe nucleus (DRN) together with a loss of TH expression within the ventral tegmental area (VTA), Substantia nigra compacta (SNc) and their subsequent outputs including the medial forebrain bundle (MFB) and striatum...
November 15, 2016: Acta Histochemica
https://www.readbyqxmd.com/read/27862513/memory-under-stress-from-single-systems-to-network-changes
#19
REVIEW
Lars Schwabe
Stressful events have profound effects on learning and memory. These effects are mainly mediated by catecholamines and glucocorticoid hormones released from the adrenals during stressful encounters. It has been known for long that both catecholamines and glucocorticoids influence the functioning of the hippocampus, a critical hub for episodic memory. However, areas implicated in other forms of memory, such as the insula or the dorsal striatum, can be affected by stress as well. Beyond changes in single memory systems, acute stress triggers the reconfiguration of large scale neural networks which sets the stage for a shift from thoughtful, 'cognitive' control of learning and memory towards more reflexive, 'habit' processes...
November 12, 2016: European Journal of Neuroscience
https://www.readbyqxmd.com/read/27859899/neural-signatures-of-trust-in-reciprocity-a-coordinate-based-meta-analysis
#20
Gabriele Bellucci, Sergey V Chernyak, Kimberly Goodyear, Simon B Eickhoff, Frank Krueger
Trust in reciprocity (TR) is defined as the risky decision to invest valued resources in another party with the hope of mutual benefit. Several fMRI studies have investigated the neural correlates of TR in one-shot and multiround versions of the investment game (IG). However, an overall characterization of the underlying neural networks remains elusive. Here, a coordinate-based meta-analysis was employed (activation likelihood estimation method, 30 articles) to investigate consistent brain activations in each of the IG stages (i...
November 17, 2016: Human Brain Mapping
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