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Dorsal striatum

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https://www.readbyqxmd.com/read/28103527/distinct-cortico-striatal-connections-with-subthalamic-nucleus-underlie-facets-of-compulsivity
#1
Laurel S Morris, Kwangyeol Baek, Valerie Voon
The capacity to flexibly respond to contextual changes is crucial to adapting to a dynamic environment. Compulsivity, or behavioural inflexibility, consists of heterogeneous subtypes with overlapping yet discrete neural substrates. The subthalamic nucleus (STN) mediates the switch from automatic to controlled processing to slow, break or stop behaviour when necessary. Rodent STN lesions or inactivation are linked with perseveration or repetitive, compulsive responding. However, there are few studies examining the role of latent STN-centric neural networks and compulsive behaviour in healthy individuals...
December 29, 2016: Cortex; a Journal Devoted to the Study of the Nervous System and Behavior
https://www.readbyqxmd.com/read/28102227/singular-location-and-signaling-profile-of-adenosine-a2a-cannabinoid-cb1-receptor-heteromers-in-the-dorsal-striatum
#2
Estefanía Moreno, Anna Chiarlone, Mireia Medrano, Mar Puigdellívol, Lucka Bibic, Lesley A Howell, Eva Resel, Nagore Puente, María J Casarejos, Juan Perucho, Joaquín Botta, Nuria Suelves, Francisco Ciruela, Silvia Ginés, Ismael Galve-Roperh, Vicent Casadó, Pedro Grandes, Beat Lutz, Krisztina Monory, Enric I Canela, Carmen Lluís, Peter J McCormick, Manuel Guzmán
The dorsal striatum is a key node for many neurobiological processes such as motor activity, cognitive functions, and affective processes. The proper functioning of striatal neurons relies critically on metabotropic receptors. Specifically, the main adenosine and endocannabinoid receptors present in the striatum, ie, adenosine A2A receptor (A2AR) and cannabinoid CB1 receptor (CB1R), are of pivotal importance in the control of neuronal excitability. Facilitatory and inhibitory functional interactions between striatal A2AR and CB1R have been reported, and evidence supports that this cross-talk may rely, at least in part, on the formation of A2AR-CB1R heteromeric complexes...
January 19, 2017: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28092323/brain-substrates-of-reward-processing-and-the-%C3%AE-opioid-receptor-a-pathway-into-pain
#3
Frauke Nees, Susanne Becker, Sabina Millenet, Tobias Banaschewski, Luise Poustka, Arun Bokde, Uli Bromberg, Christian Büchel, Patricia J Conrod, Sylvane Desrivières, Vincent Frouin, Jürgen Gallinat, Hugh Garavan, Andreas Heinz, Bernd Ittermann, Jean-Luc Martinot, Dimitri Papadopoulos Orfanos, Tomáš Paus, Michael N Smolka, Henrik Walter, Rob Whelan, Gunter Schumann, Herta Flor
The processing of reward and reinforcement learning seems to be important determinants of pain chronicity. However, reward processing is already altered early in life and if this is related to the development of pain symptoms later on is not known. The aim of this study was first to examine whether behavioural and brain-related indicators of reward processing at the age of 14 to 15 years are significant predictors of pain complaints 2 years later, at 16 to 17 years. Second, we investigated the contribution of genetic variations in the opioidergic system, which is linked to the processing of both, reward and pain, to this prediction...
February 2017: Pain
https://www.readbyqxmd.com/read/28067279/impaired-novelty-acquisition-and-synaptic-plasticity-in-congenital-hyperammonemia-caused-by-hepatic-glutamine-synthetase-deficiency
#4
Aisa N Chepkova, Olga A Sergeeva, Boris Görg, Helmut L Haas, Nikolaj Klöcker, Dieter Häussinger
Genetic defects in ammonia metabolism can produce irreversible damage of the developing CNS causing an impairment of cognitive and motor functions. We investigated alterations in behavior, synaptic plasticity and gene expression in the hippocampus and dorsal striatum of transgenic mice with systemic hyperammonemia resulting from conditional knockout of hepatic glutamine synthetase (LGS-ko). These mice showed reduced exploratory activity and delayed habituation to a novel environment. Field potential recordings from LGS-ko brain slices revealed significantly reduced magnitude of electrically-induced long-term potentiation (LTP) in both CA3-CA1 hippocampal and corticostriatal synaptic transmission...
January 9, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28067224/updating-temporal-expectancy-of-an-aversive-event-engages-striatal-plasticity-under-amygdala-control
#5
Glenn Dallérac, Michael Graupner, Jeroen Knippenberg, Raquel Chacon Ruiz Martinez, Tatiane Ferreira Tavares, Lucille Tallot, Nicole El Massioui, Anna Verschueren, Sophie Höhn, Julie Boulanger Bertolus, Alex Reyes, Joseph E LeDoux, Glenn E Schafe, Lorenzo Diaz-Mataix, Valérie Doyère
Pavlovian aversive conditioning requires learning of the association between a conditioned stimulus (CS) and an unconditioned, aversive stimulus (US) but also involves encoding the time interval between the two stimuli. The neurobiological bases of this time interval learning are unknown. Here, we show that in rats, the dorsal striatum and basal amygdala belong to a common functional network underlying temporal expectancy and learning of a CS-US interval. Importantly, changes in coherence between striatum and amygdala local field potentials (LFPs) were found to couple these structures during interval estimation within the lower range of the theta rhythm (3-6 Hz)...
January 9, 2017: Nature Communications
https://www.readbyqxmd.com/read/28057531/resting-state-brain-connectivity-patterns-before-eventual-relapse-into-cocaine-abuse
#6
M Berlingeri, D Losasso, A Girolo, E Cozzolino, T Masullo, M Scotto, M Sberna, G Bottini, E Paulesu
According to recent theories, drug addicted patients suffer of an impaired response inhibition and salience attribution (I-RISA) together with a perturbed connectivity between the nuclei accumbens (NAcs) and the orbito-prefrontal (oPFC) and dorsal prefrontal (dPFC) cortices, brain regions associated with motivation and cognitive control. To empirically test these assumptions, we evaluated the (neuro)psychological trait and the functional organization of the resting state brain networks associated with the NAcs in 18 former cocaine abusers (FCAs), while being in drug abstinence since 5 months...
January 2, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/28057474/hiv-1-tat-disrupts-blood-brain-barrier-integrity-and-increases-phagocytic-perivascular-macrophages-and-microglia-in-the-dorsal-striatum-of-transgenic-mice
#7
Crystal R Leibrand, Jason J Paris, M Said Ghandour, Pamela E Knapp, Woong-Ki Kim, Kurt F Hauser, MaryPeace McRae
HIV-1 infection results in blood brain barrier (BBB) disruption, which acts as a rate-limiting step for HIV-1 entry into the CNS and for subsequent neuroinflammatory/neurotoxic actions. One mechanism by which HIV may destabilize the BBB involves actions of the HIV-1 regulatory protein, trans-activator of transcription (Tat). We utilized a conditional, Tat-expressing transgenic murine model to examine the influence of Tat1-86 expression on BBB integrity and to assess the relative numbers of phagocytic perivascular macrophages and microglia within the CNS in vivo...
January 2, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/28049558/neonatal-handling-enduringly-decreases-anxiety-and-stress-responses-and-reduces-hippocampus-and-amygdala-volume-in-a-genetic-model-of-differential-anxiety-behavioral-volumetric-associations-in-the-roman-rat-strains
#8
Cristóbal Río-Álamos, Ignasi Oliveras, Maria Antonietta Piludu, Cristina Gerbolés, Toni Cañete, Gloria Blázquez, Silvia Lope-Piedrafita, Esther Martínez-Membrives, Rafael Torrubia, Adolf Tobeña, Alberto Fernández-Teruel
The hippocampus and amygdala have been proposed as key neural structures related to anxiety. A more active hippocampus/amygdala system has been related to greater anxious responses in situations involving conflict/novelty. The Roman Low- (RLA) and High-avoidance (RHA) rat lines/strains constitute a genetic model of differential anxiety. Relative to RHA rats, RLA rats exhibit enhanced anxiety/fearfulness, augmented hippocampal/amygdala c-Fos expression following exposure to novelty/conflict, increased hippocampal neuronal density and higher endocrine responses to stress...
December 31, 2016: European Neuropsychopharmacology: the Journal of the European College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28039087/inhibition-of-transcription-and-translation-in-the-striatum-after-memory-reactivation-lack-of-evidence-of-reconsolidation
#9
Roberto A Prado-Alcalá, Andrea Cristina Medina, Paola C Bello-Medina, Gina L Quirarte
It has been found that interference with neural activity after a consolidated memory is retrieved produces an amnestic state; this has been taken has indicative of destabilization of the memory trace that would have been produced by a process of reconsolidation (allowing for maintenance of the original trace). However, a growing body of evidence shows that this is not a reliable effect, and that it is dependent upon some experimental conditions, such as the age of the memory, memory reactivation procedures, the predictability of the reactivation stimulus, and strength of training...
December 27, 2016: Neurobiology of Learning and Memory
https://www.readbyqxmd.com/read/28035181/functional-connectivity-of-basolateral-amygdala-neurons-carrying-orexin-receptors-and-melanin-concentrating-hormone-receptors-in-regulating-sociability-and-mood-related-behaviors
#10
Tae-Kyung Kim, Pyung-Lim Han
Chronic stress induces changes in neuronal functions in specific brain regions regulating sociability and mood-related behaviors. Recently we reported that stress-induced persistent upregulation of the neuropeptides orexin and melanin-concentrating hormone (MCH) in the basolateral amygdala (BLA) and the resulting activation of orexin receptors or MCH receptors within the BLA produced deficits in sociability and mood-related behaviors. In the present study, we investigated the neural targets that were innervated by BLA neurons containing orexin receptors or MCH receptors...
December 2016: Experimental Neurobiology
https://www.readbyqxmd.com/read/28032807/region-specific-expression-of-precursor-and-mature-brain-derived-neurotrophic-factors-after-chronic-alcohol-exposure
#11
Jin-Wei Yang, Wei Ma, Yan-Lei Yang, Xian-Bin Wang, Xing-Tong Li, Tong-Tong Wang, Xiang-Peng Wang, Wei Gao, Jun-Yan Li, Xin-Fu Zhou, Jian-Hui Guo, Li-Yan Li
BACKGROUND: Alcohol abuse is a serious health problem worldwide that causes a variety of physical and mental disorders. Research has shown that the brain-derived neurotrophic factor (BDNF) plays an important role in alcohol addiction. The BDNF precursor (proBDNF) exhibits different actions than BDNF through separate receptors and pathways in the central nervous system. However, the effects of proBDNF and BDNF in alcohol addiction are not fully known. OBJECTIVES: The objective was to identify the expression patterns and effects of proBDNF and BDNF after chronic alcohol exposure...
December 29, 2016: American Journal of Drug and Alcohol Abuse
https://www.readbyqxmd.com/read/28018207/neural-correlates-for-apathy-frontal-prefrontal-and-parietal-cortical-subcortical-circuits
#12
REVIEW
Rita Moretti, Riccardo Signori
Apathy is an uncertain nosographical entity, which includes reduced motivation, abulia, decreased empathy, and lack of emotional involvement; it is an important and heavy-burden clinical condition which strongly impacts in everyday life events, affects the common daily living abilities, reduced the inner goal directed behavior, and gives the heaviest burden on caregivers. Is a quite common comorbidity of many neurological disease, However, there is no definite consensus on the role of apathy in clinical practice, no definite data on anatomical circuits involved in its development, and no definite instrument to detect it at bedside...
2016: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/28017917/intrinsic-inter-network-brain-dysfunction-correlates-with-symptom-dimensions-in-late-life-depression
#13
Wenjun Li, Yang Wang, B Douglas Ward, Piero G Antuono, Shi-Jiang Li, Joseph S Goveas
Prior studies have demonstrated dysfunctions within the core neurocognitive networks (the executive control [ECN], default mode [DMN] and salience [SN] networks) in late-life depression (LLD). Whether inter-network dysfunctional connectivity is present in LLD, and if such disruptions are associated with core symptom dimensions is unknown. A cross-sectional resting-state functional connectivity magnetic resonance imaging investigation was conducted of LLD (n = 39) and age- and gender-equated healthy comparison (HC) (n = 29) participants...
December 12, 2016: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/28004953/phosphorylation-of-tyrosine-receptor-kinase-b-in-the-dorsal-striatum-and-dorsal-hippocampus-is-associated-with-response-learning-in-a-water-plus-maze
#14
Amanda R Pahng, Paul J Colombo
The dorsal hippocampus and dorsal striatum have dissociable roles in learning and memory that are related to region-specific changes in proteins necessary for neuronal plasticity and memory formation. There is additional evidence that the hippocampus and striatum can interact during memory formation. Phosphorylation of tyrosine receptor kinase B is important for memory formation in the hippocampus, but whether or not it has a role in striatum-dependent learning, or in interactions between the hippocampus and striatum, has not been examined...
December 22, 2016: Behavioral Neuroscience
https://www.readbyqxmd.com/read/27989734/systemic-application-of-aav-vectors-targeting-gfap-expressing-astrocytes-in-z-q175-ki-huntington-s-disease-mice
#15
Tatyana Vagner, Anton Dvorzhak, Anna Maria Wójtowicz, Christoph Harms, Rosemarie Grantyn
Huntington's disease (HD) affects both neurons and astrocytes. To target the latter and to ensure brain-wide transgene expression, adeno-associated viral (AAV) vectors can be administered intravenously, as AAV vectors cross the blood-brain barrier (BBB) and enable preferential transduction of astrocytes due to their close association with blood vessels. However, there is a possibility that the subclass of GFAP-expressing astrocytes performs a distinct role in HD and reacts differently to therapeutic measures than the rest of the astrocytes...
October 27, 2016: Molecular and Cellular Neurosciences
https://www.readbyqxmd.com/read/27986497/regional-differences-in-mu-opioid-receptor-dependent-modulation-of-basal-dopamine-transmission-in-rat-striatum
#16
Y Campos-Jurado, L Martí-Prats, T Zornoza, A Polache, L Granero, M J Cano-Cebrián
The nigrostriatal dopamine system is implicated in the regulation of reward and motor activity. Dopamine (DA) release in dorsal striatum (DS) is controlled by the firing rate of DA neurons in substantia nigra pars compacta. However, influences at terminal level, such as those involving activation of mu opioid receptors (MORs), can play a key role in determining DA levels in striatum. Nonetheless, published data also suggest that the effect of opioid drugs on DA levels may differ depending on the DS subregion analyzed...
December 13, 2016: Neuroscience Letters
https://www.readbyqxmd.com/read/27984698/simultaneous-voltammetric-measurements-of-glucose-and-dopamine-demonstrate-the-coupling-of-glucose-availability-with-increased-metabolic-demand-in-the-rat-striatum
#17
Samantha K Smith, Christie A Lee, Matthew E Dausch, Brian M Horman, Heather B Patisaul, Gregory S McCarty, Leslie A Sombers
Cerebral blood flow ensures delivery of nutrients, such as glucose, to brain sites with increased metabolic demand. However, little is known about rapid glucose dynamics at discrete locations during neuronal activation in vivo. Acute exposure to many substances of abuse elicits dopamine release and neuronal activation in the striatum; however, the concomitant changes in striatal glucose remain largely unknown. Recent developments have combined fast-scan cyclic voltammetry with glucose oxidase enzyme modified carbon-fiber microelectrodes to enable the measurement of glucose dynamics with subsecond temporal resolution in the mammalian brain...
January 17, 2017: ACS Chemical Neuroscience
https://www.readbyqxmd.com/read/27984200/multi-system-state-shifts-and-cognitive-deficits-induced-by-chronic-morphine-during-abstinence
#18
Haichen Niu, Guanqun Zhang, Haiying Li, Qiang Zhang, Tongzhou Li, Sheng Ding, Lei Wang, Zhonghai Zhang, Yuehua Qiao, Min Hu
Chronic morphine administration induces neural plasticity followed by withdraw. And clinic observation indicates that obvious cognitive deficits are found during withdrawal. However, current neural substrates that regulate dysfunction in withdrawal are unknown. In our studies, chronic morphine administration was used to induce the spontaneous withdrawal model in rats. A series of cognitive abilities was tested to explore brain function. To further evaluate the neural substrates of dysfunction, Manganese-enhanced MRI(MEMRI) was used to map the dysfunctional regions in vivo...
October 28, 2016: Neuroscience Letters
https://www.readbyqxmd.com/read/27984074/alterations-in-ventral-and-dorsal-striatal-allosteric-a2ar-d2r-receptor-receptor-interactions-after-amphetamine-challenge-relevance-for-schizophrenia
#19
Julia Pintsuk, Dasiel O Borroto-Escuela, Terence K Y Lai, Fang Liu, Kjell Fuxe
Striatal dopamine D2R homodimerization is increased in the dorsal striatum after acute amphetamine challenge and in the amphetamine-induced sensitized state, a well-known animal model of schizophrenia. Therefore, it was tested if the increase in D2R homoreceptor complexes found after acute amphetamine challenge in the saline or the amphetamine sensitized state leads to changes in the antagonistic adenosine A2AR-D2R interactions in the striatum. [(3)H]-raclopride binding was performed in membrane preparations from the ventral and dorsal striatum involving competition with the D2R like agonist quinpirole...
October 29, 2016: Life Sciences
https://www.readbyqxmd.com/read/27984032/sex-and-estrous-cycle-differences-in-immediate-early-gene-activation-in-the-hippocampus-and-the-dorsal-striatum-after-the-cue-competition-task
#20
Shunya Yagi, Dimka Drewczynski, Steven R Wainwright, Cindy K Barha, Olivia Hershorn, Liisa A M Galea
The hippocampus and dorsal striatum are important structures involved in place and response learning strategies respectively. Both sex and estrous cycle phase differences in learning strategy preference exist following cue competition paradigms. Furthermore, significant effects of sex and learning strategy on hippocampal neural plasticity have been reported. However, associations between learning strategy and immediate early gene (IEG) expression in the hippocampus and dorsal striatum are not completely understood...
January 2017: Hormones and Behavior
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