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Dorsal striatum

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https://www.readbyqxmd.com/read/28727685/erbb4-signaling-in-dopaminergic-axonal-projections-increases-extracellular-dopamine-levels-and-regulates-spatial-working-memory-behaviors
#1
M Skirzewski, I Karavanova, A Shamir, L Erben, J Garcia-Olivares, J H Shin, D Vullhorst, V A Alvarez, S G Amara, A Buonanno
Genetic variants of Neuregulin 1 (NRG1) and its neuronal tyrosine kinase receptor ErbB4 are associated with risk for schizophrenia, a neurodevelopmental disorder characterized by excitatory/inhibitory imbalance and dopamine (DA) dysfunction. To date, most ErbB4 studies have focused on GABAergic interneurons in the hippocampus and neocortex, particularly fast-spiking parvalbumin-positive (PV+) basket cells. However, NRG has also been shown to modulate DA levels, suggesting a role for ErbB4 signaling in dopaminergic neuron function...
July 20, 2017: Molecular Psychiatry
https://www.readbyqxmd.com/read/28726800/role-of-nicotinamide-n-methyltransferase-in-dorsal-striatum-in-cocaine-place-preference
#2
Li Luo, Fei-Fei Shang, Hailei Long, Linhong Jiang, Ruiming Zhu, Qian Zhao, Hui Gu, Jueying Kong, Wei Xu, Yinglan Zhao, Xiaobo Cen
Nicotinamide N-methyltransferase (NNMT) transfers the methyl from S-adenosyl-L-methionine (SAM) to nicotinamide (NA) to produce S-adenosyl-L-homocysteine (SAH) and 1-methylnicotinamide (MeN). NNMT has been implicated in a variety of diseases; however, the role of NNMT in drug addiction is largely unknown. Here, we found that the expression of Nnmt was significantly upregulated in the dorsal striatum (DS) of cocaine-conditioned mice. Cocaine significantly decreased SAM/SAH ratio levels in the DS, which was accompanied with the decreased activities of Rac1 and RhoA...
July 20, 2017: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28718955/an-electrochemiluminescent-method-for-glutamate-measurement-in-small-microdialysate-samples-in-asphyxiated-young-rats
#3
Jorge Ortega-Ibarra, Silvia López-Pérez, Alberto Morales-Villagrán
Glutamate (Glu) quantification has been performed by a combination of intracerebral microdialysis through which the samples are obtained and analyzed by high performance liquid chromatography (HPLC); its measurement requires a large expenditure of time (15-30 min per sample) and special training. Therefore, an alternative method is presented here, based on the electrochemiluminescence produced by the use of an enzymatic reactor, containing glutamate-oxidase, mixed and incubated with microdialysate from dorsal striatum (DS) and prefrontal cortex (PFC) of young rats asphyxiated during the neonatal period, under a global asphyxia model in order to test this method...
July 18, 2017: Luminescence: the Journal of Biological and Chemical Luminescence
https://www.readbyqxmd.com/read/28714693/stochastic-simulation-of-dopamine-neuromodulation-for-implementation-of-fluorescent-neurochemical-probes-in-the-striatal-extracellular-space
#4
Abraham Beyene, Ian McFarlane, Rebecca Pinals, Markita P Landry
Imaging the dynamic behavior of neuromodulatory neurotransmitters in the extracelluar space arising from individual quantal releases would constitute a major advance in neurochemical imaging. Spatial and temporal resolution of these highly stochastic neuromodulatory events requires concurrent advances in the chemical development of optical nanosensors selective for neuromodulators in concert with advances in imaging methodologies to capture millisecond neurotransmitter release. Herein, we develop and implement a stochastic model to describe dopamine dynamics in the extracellular space (ECS) of the brain dorsal striatum to guide the design and implementation of fluorescent neurochemical probes that record neurotransmitter dynamics in the ECS...
July 17, 2017: ACS Chemical Neuroscience
https://www.readbyqxmd.com/read/28712121/motor-symptom-laterality-affects-acquisition-in-parkinson-s-disease-a-cognitive-and-functional-magnetic-resonance-imaging-study
#5
Pei Huang, Yu-Yan Tan, Dong-Qiang Liu, Mohammad M Herzallah, Elizabeth Lapidow, Ying Wang, Yu-Feng Zang, Mark A Gluck, Sheng-Di Chen
BACKGROUND AND OBJECTIVES: Asymmetric onset of motor symptoms in PD can affect cognitive function. We examined whether motor-symptom laterality could affect feedback-based associative learning and explored its underlying neural mechanism by functional magnetic resonance imaging in PD patients. METHODS: We recruited 63 early-stage medication-naïve PD patients (29 left-onset medication-naïve patients, 34 right-onset medication-naïve patients) and 38 matched normal controls...
July 2017: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/28709987/the-neural-correlates-of-dealing-with-social-exclusion-in-childhood
#6
Mara van der Meulen, Nikolaus Steinbeis, Michelle Achterberg, Elisabeth Bilo, Bianca G van den Bulk, Marinus H van IJzendoorn, Eveline A Crone
Observing social exclusion can be a distressing experience for children that can be followed by concerns for self-inclusion (self-concerns), as well as prosocial behavior to help others in distress (other-concerns). Indeed, behavioral studies have shown that observed social exclusion elicits prosocial compensating behavior in children, but motivations for the compensation of social exclusion are not well understood. To distinguish between self-concerns and other-concerns when observing social exclusion in childhood, participants (aged 7-10) played a four-player Prosocial Cyberball Game in which they could toss a ball to three other players...
July 12, 2017: Neuropsychologia
https://www.readbyqxmd.com/read/28707389/methamphetamine-promotes-habitual-action-and-alters-the-density-of-striatal-glutamate-receptor-and-vesicular-proteins-in-dorsal-striatum
#7
Teri M Furlong, Laura H Corbit, Robert A Brown, Bernard W Balleine
Goal-directed actions are controlled by the value of the consequences they produce and so increase when what they produce is valuable and decrease when it is not. With continued invariant practice, however, goal-directed actions can become habits, controlled not by their consequences but by antecedent, reward-related states and stimuli. Here, we show that pre-exposure to methamphetamine (METH) caused abnormally rapid development of habitual control. Furthermore, these drug-induced habits differed strikingly from conventional habits; we found that they were insensitive both to changes in reward value and to the effects of negative feedback...
July 14, 2017: Addiction Biology
https://www.readbyqxmd.com/read/28707072/catechol-o-methyltransferase-val158met-polymorphism-on-striatum-structural-covariance-networks-in-alzheimer-s-disease
#8
Chiung-Chih Chang, Shih-Jen Tsai, Nai-Ching Chen, Chi-Wei Huang, Shih-Wei Hsu, Ya-Ting Chang, Mu-En Liu, Wen-Neng Chang, Wan-Chen Tsai, Chen-Chang Lee
The catechol-O-methyltransferase enzyme metabolizes dopamine in the prefrontal axis, and its genetic polymorphism (rs4680; Val158Met) is a known determinant of dopamine signaling. In this study, we investigated the possible structural covariance networks that may be modulated by this functional polymorphism in patients with Alzheimer's disease. Structural covariance networks were constructed by 3D T1 magnetic resonance imaging. The patients were divided into two groups: Met-carriers (n = 91) and Val-homozygotes (n = 101)...
July 13, 2017: Molecular Neurobiology
https://www.readbyqxmd.com/read/28706191/aldehyde-dehydrogenase-1-positive-nigrostriatal-dopaminergic-fibers-exhibit-distinct-projection-pattern-and-dopamine-release-dynamics-at-mouse-dorsal-striatum
#9
Carmelo Sgobio, Junbing Wu, Wang Zheng, Xi Chen, Jing Pan, Armando G Salinas, Margaret I Davis, David M Lovinger, Huaibin Cai
Aldehyde dehydrogenase 1 (ALDH1A1)-positive dopaminergic (DA) neurons at the ventral substantia nigra pars compacta (SNpc) preferentially degenerate in Parkinson's disease (PD). Their projection pattern and dopamine release properties, however, remains uncharacterized. Here we show that ALDH1A1-positive axons project predominantly to the rostral two-thirds of dorsal striatum. A portion of these axons converge on a small fraction of striosome compartments restricted to the dorsolateral striatum (DLS), where less dopamine release was measured compared to the adjacent matrix enriched with the ALDH1A1-negative axons...
July 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28701918/striatal-transcriptome-and-interactome-analysis-of-shank3-overexpressing-mice-reveals-the-connectivity-between-shank3-and-mtorc1-signaling
#10
Yeunkum Lee, Sun Gyun Kim, Bokyoung Lee, Yinhua Zhang, Yoonhee Kim, Shinhyun Kim, Eunjoon Kim, Hyojin Kang, Kihoon Han
Mania causes symptoms of hyperactivity, impulsivity, elevated mood, reduced anxiety and decreased need for sleep, which suggests that the dysfunction of the striatum, a critical component of the brain motor and reward system, can be causally associated with mania. However, detailed molecular pathophysiology underlying the striatal dysfunction in mania remains largely unknown. In this study, we aimed to identify the molecular pathways showing alterations in the striatum of SH3 and multiple ankyrin repeat domains 3 (Shank3)-overexpressing transgenic (TG) mice that display manic-like behaviors...
2017: Frontiers in Molecular Neuroscience
https://www.readbyqxmd.com/read/28699296/long-lasting-contribution-of-dopamine-in-the-nucleus-accumbens-core-but-not-dorsal-lateral-striatum-to-sign-tracking
#11
Kurt M Fraser, Patricia H Janak
The attribution of incentive salience to reward-paired cues is dependent on dopamine release in the nucleus accumbens core. These dopamine signals conform to traditional reward-prediction error signals and have been shown to diminish with time. Here we examined if the diminishing dopamine signal in the nucleus accumbens core has functional implications for the expression of sign-tracking, a Pavlovian conditioned response indicative of the attribution of incentive salience to reward-paired cues. Food-restricted male Sprague-Dawley rats were trained in a Pavlovian paradigm in which an insertable lever predicted delivery of food reward in a nearby food cup...
July 12, 2017: European Journal of Neuroscience
https://www.readbyqxmd.com/read/28695319/acute-impact-of-selected-pyridoindole-derivatives-on-fos-expression-in-different-structures-of-the-rat-brain
#12
Romana Koprdova, Jana Osacka, Mojmir Mach, Alexander Kiss
The impacts of three pyridoindole derivatives (PDs), designated as PD144, PD143, and PD104, which have previously been shown to have antidepressant (PD144) and anxiolytic (PD143, PD104) properties, were investigated on the Fos expressions in 11 different rat brain areas, including the medial prefrontal cortex, striatum, septum, accumbens nucleus (shell, core), bed nucleus of the stria terminalis, hypothalamic paraventricular nucleus, central amygdala, locus coeruleus, dorsal raphe nucleus, and the solitary tract nucleus...
July 10, 2017: Cellular and Molecular Neurobiology
https://www.readbyqxmd.com/read/28694335/prior-cocaine-self-administration-increases-response-outcome-encoding-that-is-divorced-from-actions-selected-in-dorsal-lateral-striatum
#13
Amanda C Burton, Gregory B Bissonette, Adam C Zhao, Pooja K Patel, Matthew R Roesch
Dorsal lateral striatum (DLS) is a highly associative structure which encodes relationships between environmental stimuli, behavioral responses, and predicted outcomes. DLS is known to be disrupted after chronic drug abuse, however it remains unclear what neural signals in DLS are altered. Current theory suggests that drug use enhances stimuli-response processing at the expense of response-outcome encoding, but this has mostly been tested in simple behavioral tasks. Here, we ask what neural correlates in DLS are affected by previous cocaine exposure as rats perform a complex reward-guided decision-making task where predicted reward value was independently manipulated by changing the delay to or size of reward associated with a response direction across a series of trial blocks...
July 10, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28693862/behavioural-inflexibility-in-a-comorbid-rat-model-of-striatal-ischemic-injury-and-mutant-happ-overexpression
#14
Alexander Levit, Aaron M Regis, Jessica R Garabon, Seung-Hun Oh, Sagar Desai, Nagalingam Rajakumar, Vladimir Hachinski, Yuksel Agca, Cansu Agca, Shawn N Whitehead, Brian L Allman
Alzheimer disease (AD) and stroke coexist and interact; yet how they interact is not sufficiently understood. Both AD and basal ganglia stroke can impair behavioural flexibility, which can be reliably modeled in rats using an established operant based set-shifting test. Transgenic Fischer 344-APP21 rats (TgF344) overexpress pathogenic human amyloid precursor protein (hAPP) but do not spontaneously develop overt pathology, hence TgF344 rats can be used to model the effect of vascular injury in the prodromal stages of Alzheimer disease...
July 7, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/28689673/the-anatomy-of-apathy-a-neurocognitive-framework-for-amotivated-behavior
#15
C Le Heron, M A J Apps, M Husain
Apathy is a debilitating syndrome associated with many neurological disorders, including several common neurodegenerative diseases such as Parkinson's disease and Alzheimer's disease, and focal lesion syndromes such as stroke. Here, we review neuroimaging studies to identify anatomical correlates of apathy, across brain disorders. Our analysis reveals that apathy is strongly associated with disruption particularly of dorsal anterior cingulate cortex (dACC), ventral striatum (VS) and connected brain regions...
July 6, 2017: Neuropsychologia
https://www.readbyqxmd.com/read/28687422/resting-state-functional-magnetic-resonance-imaging-analysis-of-brain-functional-activity-in-rats-with-ischemic-stroke-treated-by-electro-acupuncture
#16
Shengxiang Liang, Yunjiao Lin, Bingbing Lin, Jianhong Li, Weilin Liu, Lidian Chen, Shujun Zhao, Jing Tao
OBJECTIVE: To evaluate whether electro-acupuncture (EA) treatment at acupoints of Zusanli (ST 36) and Quchi (LI 11) could reduce motor impairments and enhance brain functional recovery in rats with ischemic stroke. MATERIALS AND METHODS: A rat model of middle cerebral artery occlusion (MCAO) was established. EA at ST 36 and LI 11was started at 24 hours (MCAO + EA group) after ischemic stroke. The nontreatment (MCAO) and sham-operated control (SC) groups were included as controls...
July 4, 2017: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/28679529/timing-of-caloric-intake-during-weight-loss-differentially-affects-striatal-dopamine-transporter-and-thalamic-serotonin-transporter-binding
#17
Ruth I Versteeg, Anouk Schrantee, Sofie M Adriaanse, Unga A Unmehopa, Jan Booij, Liesbeth Reneman, Eric Fliers, Susanne E la Fleur, Mireille J Serlie
Recent studies have shown that meal timing throughout the day contributes to maintaining or regaining weight after hypocaloric diets. Although brain serotonin and dopamine are well known to be involved in regulating feeding, it is unknown whether meal timing during energy restriction affects these neurotransmitter systems. We studied the effect of a 4 wk hypocaloric diet with either 50% of daily calories consumed at breakfast (BF group) or at dinner (D group) on hypothalamic and thalamic serotonin transporter (SERT) binding and on striatal dopamine transporter (DAT) binding...
July 5, 2017: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/28675507/frontal-cortical-effects-on-feedback-processing-and-reinforcement-learning-relation-of-eeg-asymmetry-with-the-feedback-related-negativity-and-behavior
#18
Petra C Schmid, Leor M Hackel, Lee Jasperse, David M Amodio
Reinforcement learning refers to the acquisition of approach or avoidance action tendencies through repeated reward/nonreward feedback. Although much research on reinforcement learning has focused on the striatum, the prefrontal cortex likely modulates this process. Given prior research demonstrating a consistent pattern of lateralized frontal cortical activity in affective responses and approach/avoidance tendencies in the EEG literature, we aimed to elucidate the role of frontal EEG asymmetry in reinforcement learning...
July 4, 2017: Psychophysiology
https://www.readbyqxmd.com/read/28669916/imaging-neuronal-pathways-with-52-mn-pet-toxicity-evaluation-in-rats
#19
Hanna Napieczynska, Gregory W Severin, Jesper Fonslet, Stefan Wiehr, Apostolos Menegakis, Bernd J Pichler, Carsten Calaminus
Manganese in its divalent state (Mn(2+)) has features that make it a unique tool for tracing neuronal pathways. It is taken up and transported by neurons in an activity-dependent manner and it can cross synapses. It also acts as a contrast agent for magnetic resonance imaging (MRI) enabling visualization of neuronal tracts. However, due to the limited sensitivity of MRI systems relatively high Mn(2+) doses are required. This is undesirable, especially in long-term studies, because of the known toxicity of the metal...
June 30, 2017: NeuroImage
https://www.readbyqxmd.com/read/28667174/erbb4-deletion-from-medium-spiny-neurons-of-the-nucleus-accumbens-core-induces-schizophrenia-like-behaviors-via-elevated-gabaar-%C3%AE-1-expression
#20
Hong-Yan Geng, Jing Zhang, Jian-Ming Yang, Yue Li, Ning Wang, Mao Ye, Xiao-Juan Chen, Hong Lian, Xiao-Ming Li
Medium spiny neurons (MSNs), the major GABAergic projection neurons in the striatum, are implicated in many neuropsychiatric diseases, such as schizophrenia, but the underlying mechanisms remain unclear. We found that a deficiency in Erbb4, a schizophrenia risk gene, in MSNs of the nucleus accumbens (NAc) core but not the dorsomedial striatum (DMS) markedly induced schizophrenia-like behaviors such as hyperactivity, abnormal marble-burying behavior, damaged social novelty recognition and impaired sensorimotor gating function in male mice...
June 30, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
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