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Bile duct cancer

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https://www.readbyqxmd.com/read/28090223/to-resect-or-not-to-resect-extrahepatic-bile-duct-in-gallbladder-cancer
#1
REVIEW
Paschalis Gavriilidis, Alan Askari, Daniel Azoulay
The indications for and limitations of extrahepatic bile duct resection (EHBDR) in the context of gallbladder (GB) cancer are unclear. The purpose of this review was to examine the current literature to determine the impact of EHBDR on loco-regional recurrence and survival in GB cancer. The EMBASE and Medline databases were searched up to February 2016 using the terms: extrahepatic bile duct resection and gallbladder cancer. Studies published in the last 20 years were eligible for inclusion. Given the heterogeneity of the population and the study methodologies employed, qualitative data synthesis in the form of meta-analysis was deemed implausible...
February 2017: Journal of Clinical Medicine Research
https://www.readbyqxmd.com/read/28078110/radioembolization-with-90-y-glass-microspheres-for-the-treatment-of-unresectable-metastatic-liver-disease-from-chemotherapy-refractory-gastrointestinal-cancers-final-report-of-a-prospective-pilot-study
#2
Nicholas Fidelman, Robert K Kerlan, Randall A Hawkins, Miguel Pampaloni, Andrew G Taylor, Maureen P Kohi, K Pallav Kolli, Chloe E Atreya, Emily K Bergsland, R Kate Kelley, Andrew H Ko, W Michael Korn, Katherine Van Loon, Ryan M McWhirter, Jennifer Luan, Curt Johanson, Alan P Venook
BACKGROUND: This prospective pilot single-institution study was undertaken to document the feasibility, safety, and efficacy of radioembolization of liver-dominant metastatic gastrointestinal cancer using (90)Y glass microspheres. METHODS: Between June 2010 and October 2013, 42 adult patients (26 men, 16 women; median age 60 years) with metastatic chemotherapy-refractory unresectable colorectal (n=21), neuroendocrine (n=11), intrahepatic bile duct (n=7), pancreas (n=2), and esophageal (n=1) carcinomas underwent 60 lobar or segmental administrations of (90)Y glass microspheres...
December 2016: Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/28077782/serum-and-tissue-markers-in-hepatocellular-carcinoma-and-cholangiocarcinoma-clinical-and-prognostic-implications
#3
REVIEW
Massimiliano Berretta, Carla Cavaliere, Lara Alessandrini, Brigida Stanzione, Gaetano Facchini, Luca Balestreri, Tiziana Perin, Vincenzo Canzonieri
HCC represents the sixth most common cancer worldwide and the second leading cause of cancer-related death. Despite the high incidence, treatment options for advanced HCC remain limited and unsuccessful, resulting in a poor prognosis. Despite the major advances achieved in the diagnostic management of HCC, only one third of the newly diagnosed patients are presently eligible for curative treatments. Advances in technology and an increased understanding of HCC biology have led to the discovery of novel biomarkers...
December 14, 2016: Oncotarget
https://www.readbyqxmd.com/read/28070100/one-case-that-developed-bile-duct-cancer-all-over-the-progress-of-repeated-cholangitis
#4
Yugo Kawamura, Hiroaki Makiyama, Takao Nakata, Shigeaki Ishii, Shigehiro Kokubu, Michio Imawari, Masaharu Fukunaga
A 65-year-old man was referred to our department due to repeated episodes of cholangitis in the past five years. Endoscopic retrograde cholangiopancreatography was performed, and a stricture of the lower bile duct was detected. At a later date, an irregular mucosa of the bile duct was confirmed using nasal endoscopy. Based on the biopsy results, the patient was diagnosed with bile duct cancer and subsequently underwent surgery. Postoperative histopathology did not show lymph node metastasis, and the condition was determined to be early-stage bile duct cancer...
2017: Nihon Shokakibyo Gakkai Zasshi, the Japanese Journal of Gastro-enterology
https://www.readbyqxmd.com/read/28064229/outcomes-after-radio-chemo-therapy-for-non-metastatic-bile-duct-cancer
#5
Louisa Bolm, Lukas Kaesmann, Tobias Bartscht, Steven E Schild, Dirk Rades
BACKGROUND/AIM: The role of radio(chemo) therapy for non-metastatic bile duct cancer is not well defined. This study provides additional data for this rare situation. PATIENTS AND METHODS: Data of eight patients receiving radio(chemo)therapy for non-metastatic bile duct cancer were retrospectively analyzed regarding local control, metastases-free survival and overall survival. In addition to the entire cohort, five tumor- or treatment-related factors were investigated: tumor stage, histologic grading, point in time of radio(chemo)therapy, upfront surgery and concurrent chemotherapy...
January 2017: In Vivo
https://www.readbyqxmd.com/read/28064203/predictive-factors-of-gastroduodenal-bleeding-after-postoperative-radiotherapy-in-biliary-tract-cancer
#6
Jieun Lee, Do Hoon Lim, Hee Chul Park, Jeong Il Yu, Dong Wook Choi, Seong Ho Choi, Jin Seok Heo
OBJECTIVE: To identify predictive factors for gastroduodenal bleeding after postoperative radiation therapy in patients with biliary tract cancer. METHODS: We identified 186 patients with biliary tract cancer who completed scheduled postoperative radiation therapy from March 2000 to August 2013. To isolate the effects of radiation on gastroduodenal bleeding, patients with pylorus-preserving pancreaticoduodenectomy, pylorus-resecting pancreaticoduodenectomy or Whipple surgery (n = 67) were excluded from this analysis...
January 6, 2017: Japanese Journal of Clinical Oncology
https://www.readbyqxmd.com/read/28062877/-right-hepatectomy-in-block-with-hiliar-extra-hepatic-bile-duct-for-gallbladder-cancer-clinical-case
#7
Claudio Mengoa Quintanilla, Giovanni De la Cruz Robles, Sergio Puma Condori, Carol Durand Mendoza
Gallbladder cancer is the most common malignancy of the biliary tract. Usually seen in advanced stages. There are still many controversies about the type of curative surgical treatment for each stage of the disease. The only chance of long term survival for patients with advanced tumors is aggressive, large surgeries that implies multiorgan resection.We report the case of a patient with gallbladder cancer with jaundice at diagnosis, who underwent extended hepatectomy (segment IV B, segment I and extra hepatic hilar bile duct included)...
October 2016: Revista de Gastroenterología del Perú: órgano Oficial de la Sociedad de Gastroenterología del Perú
https://www.readbyqxmd.com/read/28059940/histologic-tumor-grade-and-preoperative-bilary-drainage-are-the-unique-independent-prognostic-factors-of-survival-in-pancreatic-ductal-adenocarcinoma-patients-after-pancreaticoduodenectomy
#8
Nicolás Macías, José M Sayagués, Carmen Esteban, Manuel Iglesias, Luís M González, Jose Quiñones-Sampedro, María L Gutiérrez, Luís A Corchete, Maria M Abad, Oscar Bengoechea, Luís Muñoz-Bellvis
BACKGROUND AND AIM: Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal types of cancer; most patients die during the first 6 months after diagnosis. With a 5% 5-year survival rate, is the fourth leading cause of cancer death in developed countries. In this regard, several clinical, histopathologic and biological characteristics of the disease favoring long-term survival after pancreaticoduodenectomy have been reported to be significant prognostic factors. Despite the availability of this information, there is no consensus about the different prognostic factors reported in the literature, probably due to variations in patient selection, methods, and sample size studied...
January 13, 2017: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/28053236/cd8-t-cells-that-coexpress-ror%C3%AE-t-and-t-bet-are-functionally-impaired-and-expand-in-patients-with-distal-bile-duct-cancer
#9
Stalin Chellappa, Harald Hugenschmidt, Morten Hagness, Saranya Subramani, Espen Melum, Pål Dag Line, Knut-Jørgen Labori, Gro Wiedswang, Kjetil Taskén, Einar Martin Aandahl
CD8(+) T cells that express retinoic acid-related orphan receptor (ROR)γt (TC17 cells) have been shown to promote procarcinogenic inflammation and contribute to a tolerogenic microenvironment in tumors. We investigated their phenotype and functional properties in relationship to the pathogenesis of human distal bile duct cancer (DBDC). DBDC patients had an elevated level of type 17 immune responses and the frequency of CD8(+)RORγt(+) T cells (TC17 cells) was increased in peripheral blood. The CD8(+)RORγt(+) T cells represented a highly activated subset and produced IL-17A in equal amount as CD4(+)RORγt(+) T cells (TH17 cells)...
January 4, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/28042709/health-related-quality-of-life-and-anxiety-and-depression-in-patients-diagnosed-with-cholangiocarcinoma-a-prospective-cohort-study
#10
Kristine Elberg Dengsø, Jens Hillingsø, Anne Marie Marcussen, Thordis Thomsen
BACKGROUND: Cholangiocarcinoma (CCA) is a rare cancer associated with a poor prognosis. Psychosocial challenges may negatively affect daily functioning and health-related quality of life (HRQOL). The primary aim was to evaluate HRQOL, and to assess anxiety and depression in these patients. MATERIAL AND METHODS: From 93 eligible patients diagnosed with CCA, 76 were included in a prospective cohort over a period of 15 months. Patients answered the European Organization for Research and Treatment of Cancer QLQ C30 (EORTC QLQ C30) and Hospital Anxiety and Depression Scale (HADS) questionnaires at baseline, one, three and six months after initial treatment; defined as radical operation, explorative laparotomy, chemotherapy or drainage of the bile ducts...
December 31, 2016: Acta Oncologica
https://www.readbyqxmd.com/read/28027749/pancreatic-cancer-in-patients-with-chronic-calcifying-pancreatitis-computed-tomography-findings-a-retrospective-analysis-of-48-patients
#11
Amir Mohamed, Ahmet Ayav, Arthur Belle, Xavier Orry, Jean-Baptiste Chevaux, Valerie Laurent
OBJECTIVE: Chronic calcifying pancreatitis (CCP) is a risk factor for pancreatic cancer (PC). Symptoms of PC are non-specific in patients with CCP, and diagnostic imaging can be difficult. Some studies have shown that diagnosis may take several months, leading to delays in treatment (Lin et al., 2015; Lennon et al., 2014) [2,3]. The aim of this study was to describe the radiological signs of PC in patients with CCP. METHODS: This retrospective, single-center study was conducted between January 2004 and December 2014...
January 2017: European Journal of Radiology
https://www.readbyqxmd.com/read/28011489/prognostic-impact-of-cd163-macrophages-in-tumor-stroma-and-cd8-t-cells-in-cancer-cell-nests-in-invasive-extrahepatic-bile-duct-cancer
#12
Takuya Miura, Tadashi Yoshizawa, Hideaki Hirai, Hiroko Seino, Satoko Morohashi, Yunyan Wu, Taiichi Wakiya, Norihisa Kimura, Daisuke Kudo, Keinosuke Ishido, Yoshikazu Toyoki, Hiroshi Kijima, Kenichi Hakamada
AIM: The aim of this study was to examine the clinicopathological influence of tumor-infiltrating cluster of differentiation (CD) 163(+) macrophages and CD8(+) T-cells, and to clarify the prognostic effects of these cells in patients with invasive extrahepatic bile duct cancer (EHBC). MATERIALS AND METHODS: The numbers of CD8(+) T-cells in cancer cell nests and CD163(+) macrophages in tumor stroma were evaluated using immunohistochemistry in 101 resected EHBC specimens...
January 2017: Anticancer Research
https://www.readbyqxmd.com/read/28003721/primary-biliary-cholangitis-disease-pathogenesis-and-implications-for-established-and-novel-therapeutics
#13
REVIEW
Amitkumar Patel, Anil Seetharam
Primary Biliary Cholangitis is a progressive, autoimmune cholestatic liver disorder. Cholestasis with disease progression may lead to dyslipidemia, osteodystrophy and fat-soluble vitamin deficiency. Portal hypertension may develop prior to advanced stages of fibrosis. Untreated disease may lead to cirrhosis, hepatocellular cancer and need for orthotopic liver transplantation. Classically, diagnosis is made with elevation of alkaline phosphatase, demonstration of circulating antimitochondrial antibody, and if performed: asymmetric destruction/nonsupperative cholangitis of intralobular bile ducts on biopsy...
December 2016: Journal of Clinical and Experimental Hepatology
https://www.readbyqxmd.com/read/27984121/an-s100p-positive-biliary-epithelial-field-is-a-pre-invasive-intraepithelial-neoplasm-in-nodular-sclerosing-cholangiocarcinoma
#14
Yasuni Nakanuma, Tsuneyuki Uchida, Yasunori Sato, Katsuhiko Uesaka
Nodular sclerosing cholangiocarcinoma (NS-CCA) is a common CCA of the intrahepatic large, perihilar and distal bile ducts. Intraepithelial biliary neoplasms, such as the mucosal extension of carcinoma and pre-invasive neoplastic lesions (i.e. biliary intraepithelial neoplasia [BilIN]) reportedly occur in the bile ducts around CCA. In the present study, we collectively refer to these intraepithelial lesions as "intraepithelial neoplasms of the bile duct (IENBs)". We examined the IENBs in 57 surgically resected cases of NS-CCA...
October 28, 2016: Human Pathology
https://www.readbyqxmd.com/read/27981602/prohibitin-1-suppresses-liver-cancers-tumorigenesis-in-mice-and-human-hepatocellular-and-cholangiocarcinoma-cells
#15
Wei Fan, Heping Yang, Ting Liu, Jiaohong Wang, Tony W H Li, Nirmala Mavila, Yuanyuan Tang, JinWon Yang, Hui Peng, Jian Tu, Alagappan Annamalai, Mazen Noureddin, Anuradha Krishnan, Gregory J Gores, M L Martínez-Chantar, José M Mato, Shelly C Lu
: Prohibitin 1 (PHB1) is best known as a mitochondrial chaperone and its role in cancer is conflicting. Mice lacking methionine adenosyltransferase α 1 (MATα1) have lower PHB1 expression and we reported c-MYC interacts directly with both proteins. Furthermore, c-MYC and MATα1 expert opposing effects on liver cancer growth, prompting us to examine the interplay between PHB1, MATα1 and c-MYC and PHB1's role in liver tumorigenesis. We found PHB1 is highly expressed in normal hepatocytes and bile duct epithelial cells and down-regulated in most human hepatocellular carcinoma (HCC) and cholangiocarcinoma (CCA)...
December 16, 2016: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/27965165/suspected-cases-of-cholangiocarcinoma-seen-in-reference-hospitals-in-lao-people-s-democratic-republic
#16
Phonepasong Ayé Soukhathammavong, Youthanavanh Vonghachack, Christoph Hatz, Kongsap Akkhavong, Peter Odermatt
Cholangiocarcinoma (CCA) poses a significant public health problem in Southeast Asia, with chronic Opisthorchis viverrini infection being the main risk factor. Epidemiological data on CCA is not available for Lao People Democratic Republic (Lao PDR), though there is a high prevalence of O. viverrini infection in the country. A hospital record-based retrospective study was carried out in six referral hospitals (four in the capital city, one in Savannakhet, one in Pakse) to assess the number of suspected CCA cases admitted between January 2006 and December 2010...
December 11, 2016: Parasitology International
https://www.readbyqxmd.com/read/27957308/single-incision-laparoscopy-surgery-a-systematic-review
#17
REVIEW
Sasan Saeed Far, Sepide Miraj
BACKGROUND: Laparoscopic surgery is a modern surgical technique in which operations are performed far from their location through small incisions elsewhere in the body. OBJECTIVE: This systematic review is aimed to overview single-incision laparoscopy surgery. METHODS: This systematic review was carried out by searching studies in PubMed, Medline, Web of Science, and IranMedex databases. The initial search strategy identified about 87 references...
October 2016: Electronic Physician
https://www.readbyqxmd.com/read/27957289/efficacy-of-endoscopic-ultrasonography-in-evaluation-of-undetermined-etiology-of-common-bile-duct-dilatation-on-abdominal-ultrasonography
#18
Rasoul Sotoudehmanesh, Naimeh Nejati, Maryam Farsinejad, Shadi Kolahdoozan
BACKGROUND The cause of common bile duct (CBD) dilatation cannot be determined by imaging modalities in many patients. The aim of this study was to assess the value of endoscopic ultrasonography (EUS) in detecting the cause of CBD dilatation in patients in whom ultrasonography could not demonstrate the cause of dilation. METHODS Prospectively, 152 consecutive patients who were referred for evaluation of dilated CBD (diameter ≥7 mm) of undetermined origin by ultrasonography were included in this study. All the patients underwent EUS...
October 2016: Middle East Journal of Digestive Diseases
https://www.readbyqxmd.com/read/27955658/genetic-study-of-congenital-bile-duct-dilatation-identifies-de-novo-and-inherited-variants-in-functionally-related-genes
#19
John K L Wong, Desmond Campbell, Ngoc Diem Ngo, Fanny Yeung, Guo Cheng, Clara S M Tang, Patrick H Y Chung, Ngoc Son Tran, Man-Ting So, Stacey S Cherny, Pak C Sham, Paul K Tam, Maria-Mercè Garcia-Barcelo
BACKGROUND: Congenital dilatation of the bile-duct (CDD) is a rare, mostly sporadic, disorder that results in bile retention with severe associated complications. CDD affects mainly Asians. To our knowledge, no genetic study has ever been conducted. METHODS: We aim to identify genetic risk factors by a "trio-based" exome-sequencing approach, whereby 31 CDD probands and their unaffected parents were exome-sequenced. Seven-hundred controls from the local population were used to detect gene-sets significantly enriched with rare variants in CDD patients...
December 12, 2016: BMC Medical Genomics
https://www.readbyqxmd.com/read/27951624/postoperative-radiotherapy-appeared-to-improve-the-disease-free-survival-rate-of-patients-with-extrahepatic-bile-duct-cancer-at-high-risk-of-loco-regional-recurrence
#20
Mi Young Kim, Jin Hee Kim, Yonghoon Kim, Sang Jun Byun
PURPOSE: To investigate the outcomes of postoperative radiotherapy (RT), in patients with extrahepatic bile duct (EHBD) cancer by comparing the survival rate between patients undergoing surgery alone or surgery plus postoperative RT, and to identify the prognostic factors affecting survival. MATERIALS AND METHODS: Between 2000 and 2013, 52 patients with EHBD cancer underwent surgical resection. Of these, 33 patients did not receive postoperative RT (group I), and 19 patients did (group II)...
December 2016: Radiation Oncology Journal
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