keyword
https://read.qxmd.com/read/38526383/-top-5-research-studies-of-the-month-for-italian-primary-care-physicians-march-2024
#1
JOURNAL ARTICLE
Peter K Kurotschka, Alice Serafini, Allen F Shaughnessy, David Slawson, Mark H Ebell
This monthly article provides a collection of summaries of the most relevant studies identified as POEMs (patient-oriented evidence that matters) for Italian primary care physicians. 1) A simple, well-validated risk score can help clinicians counsel patients with atrial fibrillation regarding the use of DOACs to prevent stroke. The score shares its name with the drug class (the "DOAC" score). 2) Presumably by perturbing the intestinal microbiome, antibiotic treatment is associated with an increase in the likelihood of the development of irritable bowel disease; this is especially true with multiple courses of antibiotics...
April 2024: Recenti Progressi in Medicina
https://read.qxmd.com/read/38526177/oncogenic-roles-of-laminin-subunit-gamma-2-in-intrahepatic-cholangiocarcinoma-via-promoting-egfr-translation
#2
JOURNAL ARTICLE
Jianjuan Zhang, Fubo Ji, Yaqi Tan, Lei Zhao, Yongzhi Zhao, Jiaxin Liu, Liyuan Shao, Jiong Shi, Meihua Ye, Xianglei He, Jianping Jin, Bin Zhao, Jun Huang, Stephanie Roessler, Xin Zheng, Junfang Ji
Intrahepatic cholangiocarcinoma (iCCA) is a highly lethal biliary epithelial cancer in the liver. Here, Laminin subunit gamma-2 (LAMC2) with important oncogenic roles in iCCA is discovered. In a total of 231 cholangiocarcinoma patients (82% of iCCA patients) across four independent cohorts, LAMC2 is significantly more abundant in iCCA tumor tissue compared to normal bile duct and non-tumor liver. Among 26.3% of iCCA patients, LAMC2 gene is amplified, contributing to its over-expression. Functionally, silencing LAMC2 significantly blocks tumor formation in orthotopic iCCA mouse models...
March 25, 2024: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
https://read.qxmd.com/read/38521477/impact-of-the-supra-papilla-method-on-patency-in-distal-malignant-biliary-obstruction-a-multicenter-randomized-controlled-trial
#3
JOURNAL ARTICLE
Sung Woo Ko, Hyun Don Joo, Tae Jun Song, Seongje Kim, Seong Ji Choi, Chi Hyuk Oh, Md PhD Dongwook Oh, Jin-Seok Park, Seung Bae Yoon, Md PhD Jai Hoon Yoon, Dong-Wan Seo, Sung Koo Lee
BACKGROUND: /aims: Placement of a self-expandable metal stent (SEMS) across the duodenal major papilla carries a risk of duodenobiliary reflux (DBR). The supra-papilla method of stenting may reduce DBR and improve stent patency compared to the trans-papilla method. This study aimed to compare the clinical outcomes between the supra-papilla and trans-papilla methods for distal malignant biliary obstruction (DMBO). METHODS: Between January 2021 and January 2023, consecutive patients with DMBO from six centers in Korea were randomly assigned to either the supra-papilla or trans-papilla method arm in a 1:1 ratio...
March 21, 2024: Gastrointestinal Endoscopy
https://read.qxmd.com/read/38514507/early-detection-of-occupational-cholangiocarcinoma-in-a-high-risk-patient-under-intensive-surveillance-a-case-study
#4
JOURNAL ARTICLE
Naoko Kounami, Sakae Maeda, Akihiro Kitagawa, Hideo Tomihara, Yuki Ushimaru, Nobuyoshi Ohara, Tomohira Takeoka, Mitsunobu Imasato, Ryohei Kawabata, Shingo Noura, Yumiko Yasuhara, Atsushi Miyamoto
BACKGROUND: Occupational cholangiocarcinoma is associated with exposure to organic solvents, such as dichloromethane (DCM) and 1,2-dichloropropane (DCP). This report describes a case of occupational cholangiocarcinoma detected through regularly imaging following the discovery of elevated serum γ-glutamyl trans peptidase (γ-GTP) levels revealed during regular checkup. CASE PRESENTATION: A 43-year-old man who had been working in a printing company with 15 years of exposure to organic solvents presented to our hospital owing to abnormalities found during a routine checkup...
March 22, 2024: Surgical Case Reports
https://read.qxmd.com/read/38509272/an-operative-case-of-gastric-cancer-with-ectopic-bile-duct-drainage-in-the-lesser-curvature-of-the-stomach
#5
JOURNAL ARTICLE
Kazuaki Hashimoto, Tsukasa Ihara, Yuichiro Maruyama, Shinichi Tomisaki, Hiroshi Harada
BACKGROUND: Among the various anomalies of the biliary system, a double common bile duct with ectopic drainage in the stomach is rare. Furthermore, ectopic bile ducts are extremely rare in gastric cancers. CASE PRESENTATION: A 67-year-old man was admitted to our hospital with gastric cancer and ectopic left extrahepatic bile duct drainage in the stomach. Pre-operative testing revealed no communication between the intrahepatic bile ducts. Distal gastrectomy and bile duct jejunostomy were performed...
March 21, 2024: Surgical Case Reports
https://read.qxmd.com/read/38501150/advanced-adenosquamous-carcinoma-of-the-ampulla-of-vater-treated-with-adjuvant-chemotherapy-after-pancreaticoduodenectomy
#6
JOURNAL ARTICLE
Hiroyuki Hakoda, Yoshikuni Kawaguchi, Yoichi Miyata, Junichi Togashi, Motoki Nagai, Yoshio Suzuki, Yukihiro Nomura
INTRODUCTION: Adenosquamous carcinoma (ASC) of the ampulla of Vater (AmV) is rare. The prognosis is generally worse in patients undergoing resection of ASC of the AmV than in those undergoing resection of adenocarcinoma of the AmV because the former shows early recurrence after surgery. A treatment strategy for ASC of the AmV has not been established, and the efficacy of adjuvant chemotherapy after curative resection is unclear. Given the paucity of data, we report a case of ASC of the AmV that was curatively resected and treated with adjuvant chemotherapy...
2024: Case Reports in Gastroenterology
https://read.qxmd.com/read/38499214/functional-relevance-of-mmp2-promoter-variants-in-gallbladder-cancer-a-case-control-study-in-an-eastern-indian-population
#7
JOURNAL ARTICLE
J Vinay, Shivaram Prasad Singh, Manjusha Dixit
Gallbladder cancer (GBC) is a prevalent and deadly form of bile duct cancer, associated with poor prognosis. This study aimed to investigate the genetic factors contributing to the high incidence of GBC in certain geographical regions, particularly in the Northern and Eastern parts of India. The present case-control study focused on MMP2, a gene involved in tumor progression and metastasis, as a potential candidate in GBC pathogenesis. We scanned MMP2 promoter for twelve SNPs using Sanger's sequencing and carried out a case-control study in 300 cases and 300 control samples...
March 16, 2024: Gene
https://read.qxmd.com/read/38498179/-primary-sclerosing-cholangitis-diagnosis-and-treatment-2024
#8
REVIEW
Michael Trauner, Emina Halilbasic, Elisabeth Tatscher, Peter Fickert
The etiology of primary sclerosing cholangitis (PSC) remains unclear, which explains in part the lack of a causal treatment. The differential diagnostic distinction from the even rarer immunoglobulin 4 (IgG4)-associated cholangitis (IAC) is becoming increasingly more successful. Advances in the understanding of different clinical courses, improvements in noninvasive diagnostics through modern magnetic resonance imaging (MRI) and the introduction of liver elastography have led to the development of improved prognostic models...
March 18, 2024: Inn Med (Heidelb)
https://read.qxmd.com/read/38495284/autoimmune-hepatitis-and-primary-sclerosing-cholangitis-after-direct-acting-antiviral-treatment-for-hepatitis-c-virus-a-case-report
#9
Yoshiki Morihisa, Hobyung Chung, Shuichiro Towatari, Daisuke Yamashita, Tetsuro Inokuma
BACKGROUND: Chronic hepatitis C virus (HCV) infection is a major global health concern that leads to liver fibrosis, cirrhosis, and cancer. Regimens containing direct-acting antivirals (DAAs) have become the mainstay of HCV treatment, achieving a high sustained virological response (SVR) with minimal adverse events. CASE SUMMARY: A 74-year-old woman with chronic HCV infection was treated with the DAAs ledipasvir, and sofosbuvir for 12 wk and achieved SVR. Twenty-four weeks after treatment completion, the liver enzyme and serum IgG levels increased, and antinuclear antibody became positive without HCV viremia, suggesting the development of autoimmune hepatitis (AIH)...
February 27, 2024: World Journal of Hepatology
https://read.qxmd.com/read/38491833/ultrasound-guided-percutaneous-high-frequency-irreversible-electroporation-in-porcine-livers-using-four-electrode-needles-a-feasibility-and-safety-study
#10
JOURNAL ARTICLE
Chang-Tian Li, Guo-Dong Zhao, Wen-Bo Zou, Zhen-Hua Zhang, Yi Zhao, Rong Liu
BACKGROUND: Malignant liver tumors seriously endanger human health. Among different therapeutic approaches, high-frequency irreversible electroporation (H-FIRE) is a recently emerging tumor ablation technique. The objective of this study was to evaluate the feasibility and safety of ultrasound-guided percutaneous H-FIRE using four electrode needles in porcine livers. METHODS: Twelve experimental pigs underwent percutaneous H-FIRE ablation using a compound steep-pulse therapeutic device...
March 2024: Cancer Medicine
https://read.qxmd.com/read/38491381/affinity-fine-tuning-anti-caix-car-t-cells-mitigate-on-target-off-tumor-side-effects
#11
JOURNAL ARTICLE
Yufei Wang, Alicia Buck, Brandon Piel, Luann Zerefa, Nithyassree Murugan, Christian D Coherd, Andras G Miklosi, Haraman Johal, Ricardo Nunes Bastos, Kun Huang, Miriam Ficial, Yasmin Nabil Laimon, Sabina Signoretti, Zhou Zhong, Song-My Hoang, Gabriella M Kastrunes, Marion Grimaud, Atef Fayed, Hsien-Chi Yuan, Quang-De Nguyen, Tran Thai, Elena V Ivanova, Cloud P Paweletz, Ming-Ru Wu, Toni K Choueiri, Jon O Wee, Gordon J Freeman, David A Barbie, Wayne A Marasco
One of the major hurdles that has hindered the success of chimeric antigen receptor (CAR) T cell therapies against solid tumors is on-target off-tumor (OTOT) toxicity due to sharing of the same epitopes on normal tissues. To elevate the safety profile of CAR-T cells, an affinity/avidity fine-tuned CAR was designed enabling CAR-T cell activation only in the presence of a highly expressed tumor associated antigen (TAA) but not when recognizing the same antigen at a physiological level on healthy cells. Using direct stochastic optical reconstruction microscopy (dSTORM) which provides single-molecule resolution, and flow cytometry, we identified high carbonic anhydrase IX (CAIX) density on clear cell renal cell carcinoma (ccRCC) patient samples and low-density expression on healthy bile duct tissues...
March 16, 2024: Molecular Cancer
https://read.qxmd.com/read/38491300/opisthorchis-viverrini-excretory-secretory-products-suppress-glut8-of-cholangiocytes
#12
JOURNAL ARTICLE
Sandy Kha, Sujittra Chaiyadet, Prasert Saichua, Sirikachorn Tangkawatana, Banchob Sripa, Sutas Suttiprapa
Opisthorchis viverrini infection and the subsequent bile duct cancer it induces remains a significant public health problem in Southeast Asia. Opisthorchiasis has been reported to cause reduced plasma glucose levels among infected patients. The underlying mechanism for this phenomenon is unclear. In the present study, evidence is presented to support the hypothesis that O. viverrini exploits host cholangiocyte glucose transporters (GLUTs) in a similar manner to that of rodent intestinal nematodes, to feed on unabsorbed glucose in the bile for survival...
March 16, 2024: Parasitology Research
https://read.qxmd.com/read/38489741/comprehensive-analysis-of-the-clinical-and-biological-significances-for-chemokine-cxcl3-in-cholangiocarcinoma
#13
JOURNAL ARTICLE
Hongyue Ren, Xiaofan Yang, Wenrong Hou, Jiarong Meng, Deqing Luo, Chunbin Zhang
Cholangiocarcinoma (CHOL) is a race malignant cancer arising from bile duct epithelial cells in clinical practice. C-X-C motif chemokine ligand 3 (CXCL3) is a member of chemokines family, which participates in the pathogenesis of various tumors. However, the association between CXCL3 and CHOL is unclear. This present study was to assess the role of CXCL3 expression in the progress of CHOL. TIMER, GEPIA, UALCAN, GSCA, LinkedOmics, Metascape and STRING databases were performed to evaluate the clinical and biological significances for CXCL3 with CHOL patients including expression, clinicopathological factors, immune cell infiltration, GO enrichment and KEGG pathway analyses, as well as PPI network analysis...
March 15, 2024: Medicine (Baltimore)
https://read.qxmd.com/read/38484362/prognostic-factors-in-intrahepatic-cholangiocarcinoma-a-systematic-review
#14
JOURNAL ARTICLE
Anca Zgura, Catalin Savin, Luiza Tirca, Irina Balescu, Mihai Eftimie, Sorin Petrea, Adrian Hasegan, Bogdan Gaspar, Gabriel Petre Gorecki, Cristina Martac, Marilena Stoian, Nicolae Bacalbasa
Introduction: intrahepatic cholangiocarcinoma (ICCA) are rare, aggressive cancers that develop in second order or smaller bile ducts. The aim of this review is to systematically review the most important prognostic factors affecting the long-term outcomes of these patients. Material and Methods: articles conducted on this issue, written in English, published between from January 2000 to December 2023 in Cochrane Library, PubMed, Embase, MedLine, Web of Science, Elsevier, Google Scholar were systematically researched and reviewed...
March 2024: Chirurgia
https://read.qxmd.com/read/38483785/colorectal-metastases-with-intrabiliary-growth-incidence-treatment-and-outcomes
#15
JOURNAL ARTICLE
Serena Langella, Serena Armentano, Nadia Russolillo, Andrea-Pierre Luzzi, Andrea Pierluigi Fontana, Lorenzo Daniele, Alessandro Ferrero
Intrabiliary growth (IG) is an unusual modality for colorectal metastases to spread. Relatively little is known about this condition because large series are lacking. The aim of the study was to compare the surgical and oncological outcomes of patients with or without IG. From 01/2010 to 12/2020, 999 patients underwent hepatectomy for colorectal metastases. Clinicopathological variables were retrospectively analyzed from a prospective-collected database of patients with or without IG. A propensity score matched (PSM) analysis to compare OS and DFS was performed...
March 14, 2024: Updates in Surgery
https://read.qxmd.com/read/38482714/clonal-analysis-of-metachronous-double-biliary-tract-cancers
#16
JOURNAL ARTICLE
Yuko Omori, Shuichi Aoki, Yusuke Ono, Takashi Kokumai, Shingo Yoshimachi, Hideaki Sato, Akiko Kusaka, Masahiro Iseki, Daisuke Douchi, Takayuki Miura, Shimpei Maeda, Masaharu Ishida, Masamichi Mizuma, Kei Nakagawa, Yusuke Mizukami, Toru Furukawa, Michiaki Unno
The molecular mechanisms underpinning the development of metachronous tumors in the remnant bile duct following surgical resection of primary biliary tract carcinomas (BTCs) are unknown. This study aimed to elucidate these mechanisms by evaluating the clinicopathologic features of BTCs, the alterations to 31 BTC-related genes on targeted sequencing, and the aberrant expression of p53, p16, SMAD4, ARID1A and β-catenin on immunohistochemistry. Twelve consecutive patients who underwent resection of metachronous BTCs following primary BTC resection with negative bile duct margins were enrolled...
March 14, 2024: Journal of Pathology
https://read.qxmd.com/read/38475675/serum-itih5-as-a-novel-diagnostic-biomarker-in-cholangiocarcinoma
#17
JOURNAL ARTICLE
Meiru Chen, Jinghan Ma, Xiaoli Xie, Miao Su, Dongqiang Zhao
Cholangiocarcinoma often remains undetected until advanced stages due to the lack of reliable diagnostic markers. Our goal was to identify a unique secretory protein for cholangiocarcinoma diagnosis and differentiation from other malignancies, benign hepatobiliary diseases, and chronic liver conditions. We conducted bulk RNA-seq analysis to identify genes specifically upregulated in cholangiocarcinoma but not in most other cancers, benign hepatobiliary diseases, and chronic liver diseases focusing on exocrine protein-encoding genes...
March 12, 2024: Cancer Science
https://read.qxmd.com/read/38474330/cholangiocarcinoma-malignant-traits-are-promoted-by-schwann-cells-through-tgf%C3%AE-signaling-in-a-model-of-perineural-invasion
#18
JOURNAL ARTICLE
Valerio de Franchis, Simonetta Petrungaro, Elisa Pizzichini, Serena Camerini, Marialuisa Casella, Francesca Somma, Enrico Mandolini, Guido Carpino, Diletta Overi, Vincenzo Cardinale, Antonio Facchiano, Antonio Filippini, Eugenio Gaudio, Cinzia Fabrizi, Claudia Giampietri
The term cholangiocarcinoma (CCA) defines a class of epithelial malignancies originating from bile ducts. Although it has been demonstrated that CCA patients with perineural invasion (PNI) have a worse prognosis, the biological features of this phenomenon are yet unclear. Our data show that in human intrahepatic CCA specimens with documented PNI, nerve-infiltrating CCA cells display positivity of the epithelial marker cytokeratin 7, lower with respect to the rest of the tumor mass. In an in vitro 3D model, CCA cells move towards a peripheral nerve explant allowing contact with Schwann cells (SCs) emerging from the nerve...
February 20, 2024: Cells
https://read.qxmd.com/read/38470348/synthesis-and-preclinical-evaluation-of-bold-100-radiolabeled-with-ruthenium-97-and-ruthenium-103
#19
JOURNAL ARTICLE
B Happl, T Balber, P Heffeter, C Denk, J M Welch, U Köster, C Alliot, A-C Bonraisin, M Brandt, F Haddad, J H Sterba, W Kandioller, M Mitterhauser, M Hacker, B K Keppler, T L Mindt
BOLD-100 (formerly IT-139, KP1339), a well-established chemotherapeutic agent, is currently being investigated in clinical trials for the treatment of gastric, pancreatic, colorectal, and bile duct cancer. Despite numerous studies, the exact mode of action is still the subject of discussions. Radiolabeled BOLD-100 could be a powerful tool to clarify pharmacokinetic pathways of the compound and to predict therapy responses in patients using nuclear molecular imaging prior to the therapy. In this study, the radiosyntheses of carrier-added (c...
March 12, 2024: Dalton Transactions: An International Journal of Inorganic Chemistry
https://read.qxmd.com/read/38469236/impact-of-oseltamivir-on-the-risk-of-cancer
#20
JOURNAL ARTICLE
Pei-Hua Chuang, Bor-Show Tzang, Chih-Chen Tzang, Chun-Ching Chiu, Chun-Yu Lin, Tsai-Ching Hsu
PURPOSE: Mounting evidence has revealed the anti-cancer activity of various anti-viral drugs. Oseltamivir phosphate (OP), namely Tamiflu® , is routinely used to combat influenza infections. Although evidence has indicated the anti-cancer effects of OP in vitro and in vivo , little information is known about the effect of OP use on cancers in humans. METHODS: A nationwide population-based cohort study involving 13,977,101 cases with 284,733 receiving OP was performed to examine the association between OP use and cancers using the National Health Insurance Research Database in Taiwan between 2009 and 2018...
2024: Frontiers in Oncology
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