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Bile duct cancer

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https://www.readbyqxmd.com/read/28226350/-value-of-endoscopy-application-in-the-management-of-complications-after-radical-gastrectomy-for-gastric-cancer
#1
Yiqun Zhang, Pinghong Zhou
Endoscopy plays an important role in the diagnosis and treatment of postoperative complications of gastric cancer. Endoscopic intervention can avoid the second operation and has attracted wide attention. Early gastric anastomotic bleeding after gastrectomy is the most common. With the development of technology, emergency endoscopy and endoscopic hemostasis provide a new treatment approach. According to the specific circumstances, endoscopists can choose metal clamp to stop bleeding, electrocoagulation hemostasis, local injection of epinephrine or sclerotherapy agents, and spraying specific hemostatic agents...
February 25, 2017: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
https://www.readbyqxmd.com/read/28225291/-a-contribution-to-the-differential-diagnostics-of-sclerosing-cholangitides
#2
Martin Blaho, Petr Dítě, Martina Bojková, Martin Rydlo, Tomáš Kupka, Pavel Svoboda, Pavel Klvaňa, Arnošt Martínek
Sclerosing cholangitides represent a group of chronic biliary obstructive diseases which include primary sclerosing cholangitis (PSC), IgG4 associated sclerosing cholangitis (IgG4-SC) and secondary sclerosing cholangitis (SSC). The manifestations of the diseases are similar, but their asymptomatic course is also frequent. IgG4-SC belongs to the group of IgG4 associated diseases and it is the most frequently related to type 1 autoimmune pancreatitis. Diagnosing of IgG4-SC is based on typical histopathological images, shape changes revealed by diagnostic imaging, serological tests, concurrent impairment of other organs and response to therapy, where IgG4-SC responds well to treatment with corticoids, whereas the only possibility for the remaining units is endoscopic intervention or liver transplantation...
2017: Vnitr̆ní Lékar̆ství
https://www.readbyqxmd.com/read/28224616/critical-cholangiocarcinogenesis-control-by-cryptochrome-clock-genes
#3
Ali Mteyrek, Elisabeth Filipski, Catherine Guettier, Malgorzata Oklejewicz, Gijsbertus T J van der Horst, Alper Okyar, Francis Lévi
A coordinated network of molecular circadian clocks in individual cells generates 24-hour rhythms in liver metabolism and proliferation. Circadian disruption through chronic jet lag or Per2 clock gene mutation was shown to accelerate hepatocarcinoma development in mice. Since divergent effects were reported for clock genes Per and Cry regarding xenobiotic toxicity, we questioned the role of Cry1 and Cry2 in liver carcinogenesis. Male WT and Cry1(-/-) Cry2(-/-) mice (C57Bl/6 background) were chronically exposed to diethylnitrosamine (DEN) at ZT11...
February 22, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/28205123/isolated-pancreatic-uncinate-duct-ipmn
#4
Ajay V Maker, Vijay K Maker
The ventral pancreas originally forms as an evagination of the common bile duct at 32 days gestation and its duct, the uncinate duct, eventually rotates with the ventral anlage to join the dorsal pancreas and fuse with the main pancreatic duct. Thus, though often considered a "branch" duct of the pancreas, embryologically, the uncinate duct is the "main" pancreatic duct of the ventral pancreas. This concept is not fully addressed in the current definitions of intraductal papillary mucinous neoplasms of the pancreas (IPMN) where international consensus guidelines consider the main-duct IPMN as high risk for malignancy and most small branch-duct IPMN as low risk for malignancy...
February 15, 2017: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
https://www.readbyqxmd.com/read/28205002/prognostic-impacts-of-postoperative-complications-in-patients-with-intrahepatic-cholangiocarcinoma-after-curative-operations
#5
Tatsunori Miyata, Yo-Ichi Yamashita, Takanobu Yamao, Naoki Umezaki, Masayo Tsukamoto, Yuki Kitano, Kensuke Yamamura, Kota Arima, Takayoshi Kaida, Shigeki Nakagawa, Katsunori Imai, Daisuke Hashimoto, Akira Chikamoto, Takatoshi Ishiko, Hideo Baba
BACKGROUND: The postoperative complication is one of an indicator of poor prognosis in patients with several gastroenterological cancers after curative operations. We, herein, examined prognostic impacts of postoperative complications in patients with intrahepatic cholangiocarcinoma after curative operations. METHODS: We retrospectively analyzed 60 patients with intrahepatic cholangiocarcinoma who underwent primary curative operations from June 2002 to February 2016...
February 15, 2017: International Journal of Clinical Oncology
https://www.readbyqxmd.com/read/28195651/early-estimates-of-seer-cancer-incidence-2014
#6
Denise Riedel Lewis, Huann-Sheng Chen, Myles G Cockburn, Xiao-Cheng Wu, Antoinette M Stroup, Douglas N Midthune, Zhaohui Zou, Martin F Krapcho, Daniel G Miller, Eric J Feuer
BACKGROUND: Cancer incidence rates and trends for cases diagnosed through 2014 using data reported to the Surveillance, Epidemiology, and End Results (SEER) program in February 2016 and a validation of rates and trends for cases diagnosed through 2013 and submitted in February 2015 using the November 2015 submission are reported. New cancer sites include the pancreas, kidney and renal pelvis, corpus and uterus, and childhood cancer sites for ages birth to 19 years inclusive. METHODS: A new reporting delay model is presented for these estimates for more consistent results with the model used for the usual November SEER submissions, adjusting for the large case undercount in the February submission...
February 14, 2017: Cancer
https://www.readbyqxmd.com/read/28194813/microrna-191-acts-as-a-tumor-promoter-by-modulating-the-tet1-p53-pathway-in-intrahepatic-cholangiocarcinoma
#7
Hao Li, Zun-Qiang Zhou, Zhang-Ru Yang, Da-Nian Tong, Jiao Guan, Bao-Jie Shi, Jia Nie, Xian-Ting Ding, Bin Li, Guang-Wen Zhou, Zheng-Yun Zhang
: Current treatment of intrahepatic cholangiocarcinoma (ICC) remains ineffective because knowledge of ICC carcinogenesis is unclear. Increasing evidence suggests that microRNAs (miRNAs), including miRNA-191, play an important role in tumorigenesis, but expression and biological functions of miRNA-191 in ICC remain to be established. This study aimed to investigate the functions and underlying mechanisms of miRNA-191 in ICC. ICC miRNA profiles were generated in 5 pairs of ICC and matched to normal bile duct tissues by next-generation sequencing technology; ICC miRNA profiles were verified in 18 pairs of ICC tissues and normal bile duct tissues by quantitative reverse transcription PCR (qRT-PCR)...
February 14, 2017: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/28182359/fluorescence-in-situ-hybridization-with-the-urovysion-kit-for-the-detection-of-biliary-cancer-in-chinese-patients
#8
Xi Wu, Xuan Zeng, Aiming Yang, Fang Yao, Tao Guo, Dongsheng Wu, Shafei Wu, Hongmei Qiu, Weixun Zhou, Zhen Huo, Xinghua Lu, Jiaming Qian
BACKGROUND: Conventional biliary brush via ERCP has low clinical detection for biliary malignancy. Therefore, new approaches are needed to facilitate diagnosis. We therefore explored the application of fluorescent in situ hybrization (FISH) using a UroVysion kit for the detection of malignancy in the bile duct. METHODS: Genetic alterations of target chromosomes such as aneuploidy in Chinese biliary cancer cell lines and tissues were measured using a UroVysion kit...
February 1, 2017: Clinical Laboratory
https://www.readbyqxmd.com/read/28179357/karnofsky-performance-score-is-predictive-of-survival-after-palliative-irradiation-of-metastatic-bile-duct-cancer
#9
Dirk Rades, Louisa Bolm, Lukas Kaesmann, Tobias Bartscht
BACKGROUND/AIM: Palliative irradiation is effective in alleviating symptoms in patients with metastatic cancer in general. However, little data exist regarding irradiation of metastatic bile duct cancer. Selection of the best regimen for such a patient should be based on their survival prognosis. PATIENTS AND METHODS: This study included five patients irradiated for metastatic bile duct cancer and aimed to identify predictors of survival by analyzing six factors: age, gender, general condition (Karnofsky performance score), metastatic site receiving palliative irradiation, metastases outside irradiated sites and time between diagnosis of bile duct cancer and palliative irradiation...
2017: Anticancer Research
https://www.readbyqxmd.com/read/28164557/the-detection-of-urinary-podocytes-from-drug-induced-glomerular-thrombotic-microangiopathy-in-advanced-cancer-patients
#10
Joichi Usui, Chie Yokoyama, Masahiro Hagiwara, Kai Hirayasu, Takahiro Kojima, Takayuki Yoshino, Hiroyuki Nishiyama, Masanori Hara, Kunihiro Yamagata
BACKGROUND: Focusing on glomerular thrombotic microangiopathy (TMA), we detected urinary podocytes to evaluate podocyte damage following glomerular endothelial cell injury. METHODS: We analyzed the relationship between urinary podocytes as biomarkers for podocyte injuries and clinical manifestations in five patients of anti-cancer-drug-induced glomerular TMA. RESULTS: Cancer in all five patients was advanced, including 4 cases of renal cell carcinoma treated with tyrosine kinase inhibitor, and one with intrahepatic bile duct carcinoma treated with gemcitabine...
December 1, 2016: Clinical Laboratory
https://www.readbyqxmd.com/read/28156605/the-requirement-of-fentanyl-patch-in-terminally-ill-patients-with-cancer
#11
Aya Watanabe, Hiroto Ishiki, Tsukuru Chiba, Junya Kinkawa, Chie Watanabe, Keisuke Ariyoshi, Masanori Nojima, Satoru Iwase, Arinobu Tojo
: 202 Background: Cancer pain is the most important problem to overcome in terminally ill cancer patients (TICPs). Recently, the fentanyl patch (FP) has been widely used for the treatment of cancer pain. However, the FP requirement largely varies in patients. The purpose of this study was to identify the determinants of the FP requirement in TICPs and propose effective pain relief using a FP. METHODS: In a retrospective chart review, we investigated cancer patients who were admitted in our hospital from April 2012 to July 2015 and used FP until their deaths...
October 9, 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28152549/circulating-copper-and-zinc-levels-and-risk-of-hepatobiliary-cancers-in-europeans
#12
Magdalena Stepien, David J Hughes, Sandra Hybsier, Christina Bamia, Anne Tjønneland, Kim Overvad, Aurélie Affret, Mathilde His, Marie-Christine Boutron-Ruault, Verena Katzke, Tilman Kühn, Krasimira Aleksandrova, Antonia Trichopoulou, Pagona Lagiou, Phlippos Orfanos, Domenico Palli, Sabina Sieri, Rosario Tumino, Fulvio Ricceri, Salvatore Panico, H B As Bueno-de-Mesquita, Petra H Peeters, Elisabete Weiderpass, Cristina Lasheras, Catalina Bonet Bonet, Elena Molina-Portillo, Miren Dorronsoro, José María Huerta, Aurelio Barricarte, Bodil Ohlsson, Klas Sjöberg, Mårten Werner, Dmitry Shungin, Nick Wareham, Kay-Tee Khaw, Ruth C Travis, Heinz Freisling, Amanda J Cross, Lutz Schomburg, Mazda Jenab
BACKGROUND: Copper and zinc are essential micronutrients and cofactors of many enzymatic reactions that may be involved in liver-cancer development. We aimed to assess pre-diagnostic circulating levels of copper, zinc and their ratio (Cu/Zn) in relation to hepatocellular carcinoma (HCC), intrahepatic bile duct (IHBD) and gall bladder and biliary tract (GBTC) cancers. METHODS: A nested case-control study was conducted within the European Prospective Investigation into Cancer and Nutrition cohort...
February 2, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/28138905/a-case-of-concomitant-colitic-cancer-and-intrahepatic-cholangiocarcinoma-during-follow-up-for-ulcerative-colitis
#13
Kazuyo Tsuchiya, Atsushi Nanashima, Takuto Ikeda, Shiro Minami, Motoaki Nagano, Takeomi Hamada, Koichi Yano, Yoshiro Fujii
Colitis-associated colorectal cancer (CAC) is known to occur in long-standing and extensive ulcerative colitis (UC). Furthermore, UC is known to complicate primary sclerosing cholangitis (PSC), which subsequently results in an increased risk of developing cholangiocarcinoma. We report a case of colitis-associated rectal cancer (CARC) accompanied by intrahepatic cholangiocarcinoma (ICC) based on UC and PSC. A 73-year-old man had suffered from UC for 19 years. During surveillance colonoscopy, a tumor was found in the rectum that was pathologically diagnosed as CARC from the resected specimen...
January 30, 2017: Clinical Journal of Gastroenterology
https://www.readbyqxmd.com/read/28133339/-a-case-of-lymph-node-metastasis-of-intrahepatic-bile-duct-cancer-successfully-treated-using-multidisciplinary-therapy
#14
Atsushi Miyamoto, Naoki Hama, Sakae Maeda, Mamoru Uemura, Kazuyoshi Yamamoto, Kazumasa Miyake, Kazuhiro Nishikawa, Michihiko Miyazaki, Masataka Ikeda, Motohiro Hirao, Mitsugu Sekimoto, Shoji Nakamori
We report a case of lymph node metastasis of intrahepatic bile duct cancer that was successfully treated using chemotherapy and radiation therapy.A man in his 70s underwent hepatic resection for intrahepatic bile duct cancer, and abdominal CT 1 year 8 months after surgery revealed lymph node swelling(25mm in diameter)along the common hepatic artery.He was diagnosed with lymph node metastasis and began to receive chemotherapy.We administered gemcitabine(GEM), cisplatin, and S-1 for 6 months, and GEM and S-1 for 1 year 4 further months as combination therapy...
November 2016: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/28133338/-a-case-of-axillary-lymph-node-metastases-from-distal-bile-duct-cancer
#15
Makoto Muto, Takashi Kimura, Naoya Sato, Junichiro Watanabe, Kotaro Endo, Shigeru Marubashi, Akira Kenjo, Mitsukazu Gotoh
A 67-year-old man suffered from obstructive jaundice due to distal bile duct cancer. He underwent surgery after percutaneous biliary drainage and did not received adjuvant chemotherapy afterwards. Two years after surgery, some subcutaneous nodules were detected in the left axilla and the lateral chest on enhanced CT imaging. The nodules were diagnosed as metachronous distant metastases from bile duct cancer based on pathological findings. He was treated postoperatively with S-1 and new lesions have not been detected during the 3 months after the surgery...
November 2016: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/28133236/-a-case-of-gallbladder-carcinoma-and-breast-cancer-associated-with-pancreaticobiliary-maljunction
#16
Takeshi Hijikawa, Hiroaki Kitade, Hidesuke Yanagida, Masanori Yamada, Noriko Sueoka, Aiko Ueda, Yu Tsubota, Daigo Yamamoto, Kazuhiko Yoshioka, Masanori Kon
We report a case of gallbladder cancer and right breast cancer associated with pancreaticobiliary maljunction.The patient was a 74-year-old woman who presented with abdominal pain due to cholecystitis.Abdominal CT detected a gallbladder tumor and right breast tumor.Enhanced CT and MRCP examination revealed gallbladder cancer and right breast cancer associated with pancreaticobiliary maljunction.We performed a gallbladder bed resection, bile duct resection, and right total mastectomy.The histopathological diagnosis of the gallbladder was moderately tubular adenocarcinoma and that of the breast tumor was scirrhous carcinoma...
November 2016: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/28133233/-a-case-of-distal-bile-duct-cancer-occurring-38-years-after-cyst-to-duct-anastomosis-for-a-congenital-biliary-dilatation
#17
Yuichiro Okumura, Tadafumi Asaoka, Hidetoshi Eguchi, Yoshifumi Iwagami, Daisaku Yamada, Takehiro Noda, Hiroshi Wada, Koichi Kawamoto, Kunihito Goto, Masaki Mori, Yuichiro Doki
A 41-year-old woman had undergone cyst-to-duct anastomosis for a congenital biliary dilatation when she was 3-yearold. After 38 years, she presented with a high fever, and laboratory findings showed elevation of liver and biliary enzyme levels. A CT scan showed a mass lesion in a choledochal cyst, and an adenocarcinoma was found in the anastomosis of the choledochal cyst and duodenum. We diagnosed distal bile duct cancer and performed SSPPD after neoadjuvant chemotherapy( gemcitabine plus cisplatin plus S-1)...
November 2016: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/28133218/-a-patient-with-a-pathological-complete-response-to-neo-adjuvant-chemotherapy-for-triple-negative-breast-cancer-followed-by-recurrence-after-six-months
#18
Keiko Hayashi, Mina Waraya, Takeyoshi Habiro, Satoshi Hosoya, Norihiko Sengoku, Hirokazu Tanino, Kazushige Hayakawa, Madoka Inukai, Makoto Saegusa, Masahiko Watanabe
The patient was a 68-year-old woman who received neo-adjuvant chemotherapy(4 courses of weekly paclitaxel plus bevacizumab and 4 courses of 5-fluorouracil epirubicin, and cyclophosphamide)for cT1N1M0, Stage II A right-sided triplenegative breast cancer(TNBC). Right breast-conserving surgery with axillary lymph-node dissection was performed. The postoperative pathological diagnosis was a complete response. Six months after surgery, the patient developed lower and right-sided back pain. Detailed examination revealed multiple metastases to the liver, bone, lymph nodes of the mediastinum, and bile duct...
November 2016: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/28133168/-afferent-loop-syndrome-after-hepatobiliary-and-pancreatic-surgery-successfully-treated-with-percutaneous-drainage
#19
Terukazu Yoshihara, Yoshito Tomimaru, Kaishu Tanaka, Kozo Noguchi, Shiro Hayashi, Hirotsugu Nagase, Atsushi Hamabe, Masashi Hirota, Kazuteru Oshima, Tsukasa Tanida, Tomono Kawase, Shunji Morita, Hiroshi Imamura, Takashi Iwazawa, Kenzo Akagi, Keizo Dono
We report 2 cases where afferent loop syndrome after hepatobiliary and pancreatic surgery was successfully treated with percutaneous drainage. Case 1: A 74-year-old man who had undergone pancreaticoduodenectomy for pancreatic cancer presented with cholangitis, obstructive jaundice, and dilatation of the elevated jejunum. These conditions were attributed to obstruction of the elevated jejunum on the anal side due to peritoneal dissemination. Subsequently, percutaneous transhepatic biliary drainage was performed, and the dilated jejunum was drained through the approach route...
November 2016: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/28133073/-antitumor-effects-of-a-combined-treatment-with-bortezomib-and-gemcitabine-in-bile-duct-cancer-cell-lines
#20
Kazunori Sugimura, Tsutomu Namikawa, Yuka Takezaki, Hiroyuki Kitagwa, Masaya Munekage, Kazuhiro Hanazaki
Several studies have reported that activation of nuclear factor-kappa B(NF-kB)leads to resistance to chemotherapy and radiotherapy, whereas inhibition of NF-kB activity decreases malignant manifestations and enhances sensitivity to anticancer drugs. In the present study, we used bile duct cancer(BDC)cell lines HuH28 and HuCCT1 to examine if bortezomib, an inhibitor of NF-kB activity, enhances the sensitivity to the currently used chemotherapy drug gemcitabine. We carried out experiments in the following 4 treatment groups: control, 100 nM gemcitabine, 80 nM bortezomib, and a combination of 80 nM bortezomib and 100 nM gemcitabine...
November 2016: Gan to Kagaku Ryoho. Cancer & Chemotherapy
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