Cristina Moglia, Andrea Calvo, Antonio Canosa, Umberto Manera, Rosario Vasta, Francesca Di Pede, Margherita Daviddi, Enrico Matteoni, Maura Brunetti, Luca Sbaiz, Sara Cabras, Salvatore Gallone, Maurizio Grassano, Laura Peotta, Francesca Palumbo, Gabriele Mora, Barbara Iazzolino, Adriano Chio
BACKGROUND AND OBJECTIVES: TARDBP patients are considered particularly prone to cognitive involvement, but no systematic studies of cognitive impairment in TARDBP patients are available. The aim of this article was to depict in depth the cognitive-behavioral characteristics of a cohort of patients with amyotrophic lateral sclerosis (ALS) carrying TARDBP pathogenetic variants followed by an ALS referral center. METHODS: We enrolled all patients with ALS seen at the Turin ALS expert center in the 2009-2021 period who underwent extensive genetic testing and a neuropsychological battery encompassing executive function, verbal memory, language, visual memory, visuoconstructive abilities, attention/working memory, psychomotor speed, nonverbal intelligence, cognitive flexibility, social cognition, and behavior...
February 27, 2024: Neurology