Yan Yi, Jing Fu, Shi Xie, Qiong Zhang, Bin Xu, Yonggang Wang, Yijing Wang, Bin Li, Guihu Zhao, Jinchen Li, Yanping Li, Jing Zhao
STUDY QUESTION: Can potential mechanisms involved in the likely concurrence of diminished ovarian reserve (DOR) and miscarriage be identified using genetic data? SUMMARY ANSWER: Concurrence between ovarian reserve and spontaneous miscarriage was observed, and may be attributed to shared genetic risk loci enriched in antigen processing and presentation and autoimmune disease pathways. WHAT IS KNOWN ALREADY: Previous studies have shown that lower serum anti-Müllerian hormone (AMH) levels are associated with increased risk of embryo aneuploidy and spontaneous miscarriage, although findings have not been consistent across all studies...
November 2, 2023: Human Reproduction