Jutta S Mayer, Laura Kohlhas, Jacek Stermann, Juliane Medda, Geva A Brandt, Oliver Grimm, Adam D Pawley, Philip Asherson, Judit Palacio Sanchez, Vanesa Richarte, Douwe Bergsma, Elena D Koch, Adrià Muntaner-Mas, Ulrich W Ebner-Priemer, Meinhard Kieser, Wolfgang Retz, Francisco B Ortega, Michael Colla, Jan K Buitelaar, Jonna Kuntsi, Josep A Ramos-Quiroga, Andreas Reif, Christine M Freitag
Depression is common in attention-deficit/hyperactivity disorder (ADHD), but preventive behavioural interventions are lacking. This randomised controlled, pilot phase-IIa trial aimed to study a physical exercise intervention (EI) and bright light therapy (BLT)-both implemented and monitored in an individual, naturalistic setting via a mobile health (m-health) system-for feasibility of trial design and interventions, and to estimate their effects on depressive symptoms in young people with ADHD. Two hundred seven participants aged 14-45 years were randomised to 10-week add-on intervention of either BLT (10,000 lx; daily 30-min sessions) (n = 70), EI (aerobic and muscle-strengthening activities 3 days/ week) (n = 69), or treatment-as-usual (TAU) (n = 68), of whom 165 (80%) were retained (BLT: n = 54; EI: n = 52; TAU: n = 59)...
April 16, 2024: European Archives of Psychiatry and Clinical Neuroscience