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Reward dysfunction

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https://www.readbyqxmd.com/read/29444252/human-striatal-response-to-reward-anticipation-linked-to-hippocampal-glutamate-levels
#1
Matthijs G Bossong, Robin Wilson, Elizabeth Appiah-Kusi, Philip McGuire, Sagnik Bhattacharyya
Background: Dysfunctional reward processing is associated with a number of psychiatric disorders, such as addiction and schizophrenia. It is thought that reward is regulated mainly by dopamine transmission in the ventral striatum. Contemporary animal models suggest that striatal dopamine concentrations and associated behaviours are related to glutamatergic functioning in the ventral hippocampus. However, in humans the association between reward-related ventral striatal response and hippocampal glutamate levels is unclear...
February 10, 2018: International Journal of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29439750/differential-neural-reward-mechanisms-in-treatment-responsive-and-treatment-resistant-schizophrenia
#2
Lucy D Vanes, Elias Mouchlianitis, Tracy Collier, Bruno B Averbeck, Sukhi S Shergill
BACKGROUND: The significant proportion of schizophrenia patients refractory to treatment, primarily directed at the dopamine system, suggests that multiple mechanisms may underlie psychotic symptoms. Reinforcement learning tasks have been employed in schizophrenia to assess dopaminergic functioning and reward processing, but these have not directly compared groups of treatment-refractory and non-refractory patients. METHODS: In the current functional magnetic resonance imaging study, 21 patients with treatment-resistant schizophrenia (TRS), 21 patients with non-treatment-resistant schizophrenia (NTR), and 24 healthy controls (HC) performed a probabilistic reinforcement learning task, utilizing emotionally valenced face stimuli which elicit a social bias toward happy faces...
February 14, 2018: Psychological Medicine
https://www.readbyqxmd.com/read/29436061/anterior-insular-volume-decrease-is-associated-with-dysfunction-of-the-reward-system-in-patients-with-chronic-pain
#3
E Ikeda, T Li, H Kobinata, S Zhang, J Kurata
BACKGROUND: Chronification of pain is associated with both anatomical and functional alterations of the brain. Alteration in regional gray matter volume might potentially be associated with modified activity of specific brain networks. In this cross-sectional, observational study, we sought to identify brain regions with gray matter volume changes in patients with chronic pain and to reveal its significance by analysing alteration in functional connectivity from those regions. We further explored relevance of such alterations with psychometrics of chronic pain...
February 13, 2018: European Journal of Pain: EJP
https://www.readbyqxmd.com/read/29423135/altered-reward-system-reactivity-for-personalized-circumscribed-interests-in-autism
#4
Gregor Kohls, Ligia Antezana, Maya G Mosner, Robert T Schultz, Benjamin E Yerys
Background: Neurobiological research in autism spectrum disorders (ASD) has paid little attention on brain mechanisms that cause and maintain restricted and repetitive behaviors and interests (RRBIs). Evidence indicates an imbalance in the brain's reward system responsiveness to social and non-social stimuli may contribute to both social deficits and RRBIs. Thus, this study's central aim was to compare brain responsiveness to individual RRBI (i.e., circumscribed interests), with social rewards (i...
2018: Molecular Autism
https://www.readbyqxmd.com/read/29407687/cognitive-deficits-in-individuals-with-methamphetamine-use-disorder-a-meta-analysis
#5
REVIEW
Stéphane Potvin, Julie Pelletier, Stéphanie Grot, Catherine Hébert, Alastair Barr, Tania Lecomte
BACKGROUND: Methamphetamine has long been considered as a neurotoxic substance causing cognitive deficits. Recently, however, the magnitude and the clinical significance of the cognitive effects associated with methamphetamine use disorder (MUD) have been debated. To help clarify this controversy, we performed a meta-analysis of the cognitive deficits associated with MUD. METHODS: A literature search yielded 44 studies that assessed cognitive dysfunction in 1592 subjects with MUD and 1820 healthy controls...
January 30, 2018: Addictive Behaviors
https://www.readbyqxmd.com/read/29407682/sociodemographic-and-psychopathological-predictors-of-criminal-behavior-in-women-with-gambling-disorder
#6
Gemma Mestre-Bach, Trevor Steward, Roser Granero, Fernando Fernández-Aranda, María Teresa Talón-Navarro, Àngel Cuquerella, Amparo Del Pino-Gutiérrez, Neus Aymamí, Mónica Gómez-Peña, Núria Mallorquí-Bagué, Teresa Mena-Moreno, Cristina Vintró-Alcaraz, Marta Baño, Laura Moragas, Pablo Magaña, José Manuel Menchón, Susana Jiménez-Murcia
INTRODUCTION: Women have been underrepresented in the empirical research of gambling disorder (GD), a psychiatric condition included in the Diagnostic and Statistical Manual of Mental Health Disorders (DSM-5). More specifically, no studies to date have been carried out exploring the clinical phenotype of women with GD who have committed gambling-related illegal acts. AIMS: In this study, we sought to delineate the clinical, personality and psychopathological differences between treatment-seeking women with GD, with and without a criminal record...
January 24, 2018: Addictive Behaviors
https://www.readbyqxmd.com/read/29397080/distinct-associations-between-low-positive-affect-panic-and-neural-responses-to-reward-and-threat-during-late-stages-of-affective-picture-processing
#7
Anna Weinberg, Aislinn Sandre
BACKGROUND: Abnormal patterns of attention to threat and reward have been proposed as potential mechanisms of dysfunction in anxiety and mood disorders. However, research on this topic has been inconsistent, perhaps because of both clinical heterogeneity in the samples assessed and measurement of attentional biases that is temporally imprecise. METHODS: The present study measured transdiagnostic symptoms of anxiety and depression in 205 young adults and recorded affect-modulated event-related potentials in response to task-irrelevant pictures in a speeded response task...
January 2018: Biological Psychiatry: Cognitive Neuroscience and Neuroimaging
https://www.readbyqxmd.com/read/29394100/sleep-health-and-psychopathology-mediate-executive-deficits-in-pediatric-obesity
#8
Alaina L Pearce, Eleanor Mackey, Evan P Nadler, Chandan J Vaidya
OBJECTIVE: Executive and motivational dysfunction have been associated with pediatric obesity. Poor sleep quality and psychopathology, often comorbid with obesity, are also associated with executive and motivational dysfunction. We examined the contribution of these comorbid factors to the association between obesity and executive function and reward-related decision-making. METHODS: Seven- to 18-year-old children with and without obesity performed a working memory task with low and high loads, a response inhibition task, and a probabilistic reward-related decision-making task...
February 2, 2018: Childhood Obesity
https://www.readbyqxmd.com/read/29357198/inactivation-of-nucleus-reuniens-impairs-spatial-working-memory-and-behavioral-flexibility-in-the-rat
#9
Tatiana D Viena, Stephanie B Linley, Robert P Vertes
The hippocampal formation (HF) and medial prefrontal cortex (mPFC) play critical roles in spatial working memory (SWM). The nucleus reuniens (RE) of the ventral midline thalamus is an important anatomical link between the HF and mPFC, and as such is crucially involved SWM functions that recruit both structures. Little is known, however, regarding the role of RE in other behaviors mediated by this circuit. In the present study, we examined the role of RE in spatial working memory and executive functioning following reversible inactivation of RE with either muscimol or procaine...
January 22, 2018: Hippocampus
https://www.readbyqxmd.com/read/29355692/pregabalin-induces-conditioned-place-preference-in-the-rat-during-the-early-but-not-late-stage-of-neuropathic-pain
#10
Yuta Asaoka, Takahiro Kato, Soichiro Ide, Taiju Amano, Masabumi Minami
The present study aimed to examine the rewarding effects of pain relief during the early and late stages of neuropathic pain using a conditioned place preference (CPP) test. Animal models of neuropathic pain were prepared by spinal nerve ligation in male Sprague-Dawley rats. Intraperitoneal and intrathecal injections of pregabalin (300 mg/kg and 100 μg/10 μL, respectively) suppressed allodynia in the von Frey test both 2 weeks (early stage) and 4 weeks (late stage) after nerve injury. Intraperitoneal and intrathecal injections of pregabalin induced CPP during the early stage of neuropathic pain, suggesting that the CPP test serves as an objective and quantifiable behavioral assay to assess the emotional aspect of pain relief...
January 17, 2018: Neuroscience Letters
https://www.readbyqxmd.com/read/29339724/granulocyte-colony-stimulating-factor-controls-neural-and-behavioral-plasticity-in-response-to-cocaine
#11
Erin S Calipari, Arthur Godino, Emily G Peck, Marine Salery, Nicholas L Mervosh, Joseph A Landry, Scott J Russo, Yasmin L Hurd, Eric J Nestler, Drew D Kiraly
Cocaine addiction is characterized by dysfunction in reward-related brain circuits, leading to maladaptive motivation to seek and take the drug. There are currently no clinically available pharmacotherapies to treat cocaine addiction. Through a broad screen of innate immune mediators, we identify granulocyte-colony stimulating factor (G-CSF) as a potent mediator of cocaine-induced adaptations. Here we report that G-CSF potentiates cocaine-induced increases in neural activity in the nucleus accumbens (NAc) and prefrontal cortex...
January 16, 2018: Nature Communications
https://www.readbyqxmd.com/read/29336871/epigenetic-regulation-of-the-kappa-opioid-receptor-gene-by-an-insertion-deletion-in-the-promoter-region
#12
Pierre-Eric Lutz, Daniel Almeida, Raoul Belzeaux, Ipek Yalcin, Gustavo Turecki
Preclinical and clinical studies have demonstrated that the kappa opioid receptor (KOR) regulates reward, hedonic tone and emotions. At therapeutic level, on-going clinical trials are assessing the potential of targeting the KOR for the management of depression, anxiety disorders and substance use disorders. However, genetic polymorphisms in the KOR gene that potentially contribute to its implication in these phenotypes have been poorly studied. Here we investigated an insertion-deletion in the promoter region of KOR (rs35566036), recently associated with alcohol addiction, in a cohort of depressed subjects who died by suicide, as well as psychiatrically healthy individuals...
January 11, 2018: European Neuropsychopharmacology: the Journal of the European College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29336819/identification-of-a-corticohabenular-circuit-regulating-socially-directed-behavior
#13
Madhurima Benekareddy, Tevye Jason Stachniak, Andreas Bruns, Frederic Knoflach, Markus von Kienlin, Basil Künnecke, Anirvan Ghosh
BACKGROUND: The prefrontal cortex (PFC) has been implicated in the pathophysiology of social dysfunction, but the specific circuit partners mediating PFC function in health and disease are unclear. METHODS: The excitatory designer receptor exclusively activated by designer drugs (DREADD) hM3Dq was used to induce PFC activation during social behavior measured in the three-chamber sociability assay (rats/mice). Functional magnetic resonance imaging was combined with hM3Dq-mediated PFC activation to identify novel nodes in the "social brain" in a hypothesis-free manner...
December 2, 2017: Biological Psychiatry
https://www.readbyqxmd.com/read/29309800/partial-reversal-of-the-effort-related-motivational-effects-of-tetrabenazine-with-the-mao-b-inhibitor-deprenyl-selegiline-implications-for-treating-motivational-dysfunctions
#14
Hector Contreras-Mora, Megan A Rowland, Samantha E Yohn, Merce Correa, John D Salamone
People with depression and Parkinsonism frequently show effort-related motivational symptoms, such as anergia, psychomotor retardation, and fatigue. Tasks that assess effort-related choice are being used as animal models of these motivational symptoms. The present studies characterized the ability of monoamine oxidase (MAO) inhibitors with varying selectivity profiles to reverse the low effort bias induced by the monoamine storage inhibitor tetrabenazine. Tetrabenazine produces depressive symptoms in humans, and because of its selective inhibition of VMAT-2, it preferentially depletes DA at low doses...
January 5, 2018: Pharmacology, Biochemistry, and Behavior
https://www.readbyqxmd.com/read/29307561/reward-processing-dysfunction-in-ventral-striatum-and-orbitofrontal-cortex-in-parkinson-s-disease
#15
Stéfan du Plessis, Meija Bossert, Matthijs Vink, Leigh van den Heuvel, Soraya Bardien, Robin Emsley, Chanelle Buckle, Soraya Seedat, Jonathan Carr
BACKGROUND: Parkinson's disease is a growing concern as the longevity of the world's population steadily increases. Both ageing and Parkinson's disease have an impact on dopamine neurotransmission. It is therefore important to investigate their relative impact on the fronto-striatal reward system. There has been little investigation of reward processing in terms of anticipation and reward outcome in Parkinson's disease. Abnormal responses during reward processing have previously been demonstrated in whole-brain analysis of Parkinson's patients with mild lateralized disease, but the exact impact in regions specific to reward processing is still unknown...
December 24, 2017: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/29303969/workaholism-as-a-mediator-between-work-related-stressors-and-health-outcomes
#16
Cecilie Schou Andreassen, Ståle Pallesen, Torbjørn Torsheim
It is currently unknown if unfavorable working conditions, reflected by the demand-control-support model and the effort-reward imbalance model, directly influence health or if the effects may be mediated by work-related attitudes and behaviors such as workaholism. In the present study, 988 employees (55.6% males, mean age 36.09, SD = 9.23) from a large consultant firm participated in a cross-sectional survey assessing work variables such as job demands, job control, social support, effort, reward, and overcommitment...
January 5, 2018: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29303955/reward-dysfunction-in-the-manic-spectrum-unable-to-win-the-use-of-biographical-information-to-refine-neurobiological-modeling
#17
David A Kahn
OBJECTIVE: The manic spectrum is thought to be characterized by a hypersensitive biobehavioral reward system, the behavioral activation system. Evidence for this framework comes from questionnaire-based, self-report data collected in cross-sectional and prospective studies of mania, mania in remission, and proneness to hypomania, and from functional neuroimaging investigations of brain reward circuit activity during incentivized choice protocols. Although heightened reward anticipation is consistently documented, the status of later goal attainment activity, hedonic responses, and satiety reactions is less clear...
November 2017: Journal of Psychiatric Practice
https://www.readbyqxmd.com/read/29303954/reward-dysfunction-in-the-manic-spectrum-unable-to-win-the-use-of-biographical-information-to-refine-neurobiological-modeling
#18
John F Gottlieb
OBJECTIVE: The manic spectrum is thought to be characterized by a hypersensitive biobehavioral reward system, the behavioral activation system. Evidence for this framework comes from questionnaire-based, self-report data collected in cross-sectional and prospective studies of mania, mania in remission, and proneness to hypomania, and from functional neuroimaging investigations of brain reward circuit activity during incentivized choice protocols. Although heightened reward anticipation is consistently documented, the status of later goal attainment activity, hedonic responses, and satiety reactions is less clear...
November 2017: Journal of Psychiatric Practice
https://www.readbyqxmd.com/read/29285721/altered-monetary-loss-processing-and-reinforcement-based-learning-in-individuals-with-obesity
#19
Jana Kube, David Mathar, Annette Horstmann, Sonja A Kotz, Arno Villringer, Jane Neumann
Individuals with obesity are often characterized by alterations in reward processing. This may affect how new information is used to update stimulus values during reinforcement-based learning. Here, we investigated obesity-related changes in non-food reinforcement processing, their impact on learning performance as well as the neural underpinnings of reinforcement-based learning in obesity. Nineteen individuals with obesity (BMI > = 30 kg/m2, 10 female) and 23 lean control participants (BMI 18.5-24...
December 29, 2017: Brain Imaging and Behavior
https://www.readbyqxmd.com/read/29247674/developmental-exposure-to-low-level-ambient-ultrafine-particle-air-pollution-and-cognitive-dysfunction
#20
D A Cory-Slechta, J L Allen, K Conrad, E Marvin, M Sobolewski
Developmental exposures to ambient ultrafine particles (UFPs) can produce multiple neuropathological and neurochemical changes that might contribute to persistent alterations in cognitive-type functions. The objective of the current study was to test the hypothesis that developmental UFP exposure produced impairments in learning, memory and impulsive-like behaivors and to determine whether these were selective and thus independent of deficits in other behavioral domains such as motor activity or motivation...
December 13, 2017: Neurotoxicology
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