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https://www.readbyqxmd.com/read/29775793/analysis-of-dna-methylation-at-specific-loci-in-stool-samples-detects-colorectal-cancer-and-high-grade-dysplasia-in-patients-with-inflammatory-bowel-disease
#1
John B Kisiel, Pasquale Klepp, Hatim T Allawi, William R Taylor, Maria Giakoumopoulos, Tamara Sander, Tracy C Yab, Bjorn A Moum, Graham P Lidgard, Stephan Brackmann, Douglas W Mahoney, Arne Roseth, David A Ahlquist
BACKGROUND & AIMS: Patients with inflammatory bowel diseases (IBD), including ulcerative colitis (UC) and Crohn's disease (CD), are at increased risk for colorectal cancer (CRC). Analyses of DNA methylation patterns in stool samples have been reported to detect CRC in patients with IBD. We sought to validate these findings in larger cohorts and assess the accuracy of analysis of DNA methylation patterns in stool for detection of CRC and high-grade dysplasia (HGD) normalized to methylation level at ZDHHC1...
May 15, 2018: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29774226/metastatic-gastric-signet-ring-cell-carcinoma-mimicking-crohn-s-disease
#2
Michael W Winter, Amr Dokmak, Zachary Marnoy, Shweta Sinagare, Alexander N Levy
Signet-ring cell carcinoma (SRCC) is an adenocarcinoma characterized by mucin-producing cells and most commonly arises in the stomach. Colonic SRCC can share features of colitis, including long segments of concentric bowel wall thickening and ulcerated mucosa with regions of sparing. We describe a rare case of metastatic gastric SRCC mimicking Crohn's disease. Our patient underwent 2 colonoscopies, and biopsies revealed chronic active inflammation with no evidence of malignancy. The diagnosis of SRCC was only made after colectomy was performed for recurrent bowel obstruction...
2018: ACG Case Reports Journal
https://www.readbyqxmd.com/read/29774225/polypectomy-for-recurrent-inflammatory-cap-polyposis-combined-with-argon-plasma-coagulation
#3
Soros Anuchapreeda, Patduangpuk Phengsuthi, Prapimphan Aumpansub, Naruemon Wisedopas, Thawee Ratanachuek
A 15-year-old adolescent boy presented with chronic constipation, difficulty in defecation, and episodic bloody stools. A rectal mass lesion was digitally palpated. Colonoscopy showed a large circumferential polypoid lesion of the mid-rectum. Snare polypectomy was performed, and histopathology confirmed a diagnosis of benign inflammatory cap polyposis. At 3-month follow-up, sigmoidoscopy showed multiple recurrences of polyps at the site of the previous rectal polypectomy, which were removed by combined hot snare polypectomy and argon plasma coagulation...
2018: ACG Case Reports Journal
https://www.readbyqxmd.com/read/29774162/a-large-proportion-of-fecal-immunochemical-test-positive-participants-in-colorectal-cancer-screening-is-symptomatic
#4
Clasine M de Klerk, Manon van der Vlugt, Patrick M Bossuyt, Evelien Dekker
Background: Symptomatic invitees are advised not to participate in colorectal cancer (CRC) screening but to directly consult their general practitioner (GP), because fecal immunochemical test (FIT) sensitivity for cancer is not optimal. This recommendation may not always be followed in daily practice. We evaluated how many FIT-positive participants had CRC-related symptoms and whether the presence of symptoms was associated with the presence and location of CRC/advanced neoplasia. Methods: We prospectively collected data on CRC-related symptoms in all FIT-positive participants in the Dutch CRC screening program, referred to our endoscopy centers between 2014 and 2016, and evaluated whether symptoms were associated with detected CRC/advanced neoplasia at colonoscopy...
April 2018: United European Gastroenterology Journal
https://www.readbyqxmd.com/read/29774160/underwater-endoscopic-colorectal-polyp-resection-feasibility-in-everyday-clinical-practice
#5
Sergio Cadoni, Mauro Liggi, Paolo Gallittu, Donatella Mura, Lorenzo Fuccio, Malcolm Koo, Sauid Ishaq
Background: Endoscopic mucosal resection is well-established for resecting flat or sessile benign colon polyps. The novel underwater endoscopic mucosal resection eschews submucosal injection prior to endoscopic mucosal resection. Reports about underwater endoscopic mucosal resection were limited to small series of single and/or tertiary-care referral centers, with single or supervised operators. Objective: The purpose of this study was to determine feasibility and efficacy of underwater resection of polyps of any morphology (underwater polypectomy, here includes underwater endoscopic mucosal resection) in routine clinical practice...
April 2018: United European Gastroenterology Journal
https://www.readbyqxmd.com/read/29774146/endoscopic-and-angiographic-management-of-lower-gastrointestinal-bleeding-review-of-the-published-literature
#6
REVIEW
David J Werner, Hendrik Manner, Marc Nguyen-Tat, Roman Kloeckner, Ralf Kiesslich, Nael Abusalim, Johannes W Rey
Lower gastrointestinal bleeding is common and occurs often in elderly patients. In rare cases it is associated with hemorrhagic shock. A large number of such bleedings, which are often caused by colon diverticula, subside spontaneously. Alternatively they can be treated by endoscopic procedures successfully. Given the aging population of our society, the rising incidence of lower gastrointestinal tract bleeding and new anticoagulant therapies, some of the bleedings tend to be severe. Colonoscopy is the established standard procedure for the diagnosis and treatment of lower gastrointestinal bleeding...
April 2018: United European Gastroenterology Journal
https://www.readbyqxmd.com/read/29771698/updates-in-colorectal-cancer-screening-in-inflammatory-bowel-disease
#7
William T Clarke, Joseph D Feuerstein
PURPOSE OF REVIEW: This review article will discuss the risk of colorectal cancer (CRC) in patients with inflammatory bowel disease (IBD), as well as the current recommendations for CRC screening and surveillance in patients with ulcerative colitis or Crohn's colitis involving one-third of the colon. RECENT FINDINGS: Given that most cases of CRC are thought to arise from dysplasia, previous guidelines have recommended endoscopic surveillance with random biopsies obtained from all segments of the colon...
May 15, 2018: Current Opinion in Gastroenterology
https://www.readbyqxmd.com/read/29770281/intestinal-spirochetosis-in-an-immunocompetent-patient
#8
Patricia Guzman Rojas, Jelena Catania, Jignesh Parikh, Tran C Phung, Glenn Speth
Intestinal spirochetosis (IS) is an infestation defined by the presence of spirochetes on the surface of the colonic mucosa. The implicated organisms can be Brachyspira aalborgi or Brachyspira pilosicoli . We present the case of a 66-year-old man with a past medical history of diabetes mellitus, hypertension, morbid obesity, and gastroesophageal reflux. The patient was sent to the gastroenterology clinic for a screening colonoscopy due to a prior history of colonic polyps. The patient was completely asymptomatic as he denies any abdominal pain, diarrhea, melena, or hematochezia...
March 15, 2018: Curēus
https://www.readbyqxmd.com/read/29770208/case-report-polyarteritis-nodosa-or-complicated-henoch-schonlein-purpura-a-rare-case
#9
Sajad Hasanzadeh, Seyedeh Maryam Alavi, Elahe Masnavi, Maryam Rohani, Saeid Jokar
Background: Polyarteritis nodosa (PAN) is a vasculitis that affects medium sized arteries. PAN is a rare disease and requires a high vilgilance for diagnosis. For instance, PAN and Henoch-Schonlein purpura (HSP) have narrowing differential diagnosis. Here, we report a case of PAN. Case presentation : Our patient was a 65 year old woman that came to hospital due to abdominal pain and skin lesion on the right upper and right lower extremities. All rheumatologic tests were negative. A biopsy of the skin lesion was reported as mild hyperkeratosis, slight spongiosis with intact basal layer...
2018: F1000Research
https://www.readbyqxmd.com/read/29768508/i-scan-optical-enhancement-for-the-in-vivo-prediction-of-diminutive-colorectal-polyp-histology-results-from-a-prospective-three-phased-multicentre-trial
#10
Entcho Klenske, Steffen Zopf, Clemens Neufert, Andreas Nägel, Jürgen Siebler, Jürgen Gschossmann, Steffen Mühldorfer, Lukas Pfeifer, Sarah Fischer, Francesco Vitali, Marietta Iacucci, Subrata Ghosh, Michelle G Rath, Peter Klare, Gian E Tontini, Markus F Neurath, Timo Rath
BACKGROUND AND AIMS: Dye-less chromoendoscopy is an emerging technology for colorectal polyp characterization. Herein, we investigated whether the newly introduced I-scan optical enhancement (OE) can accurately predict polyp histology in vivo in real-time. METHODS: In this prospective three-phased study, 84 patients with 230 diminutive colorectal polyps were included. During the first two study phases, five endoscopists assessed whether analysis of polyp colour, surface and vascular pattern under i-scan OE can differentiate in vivo between adenomatous and hyperplastic polyps...
2018: PloS One
https://www.readbyqxmd.com/read/29768328/efficacy-and-safety-of-etomidate-midazolam-for-screening-colonoscopy-in-the-elderly-a-prospective-double-blinded-randomized-controlled-study
#11
Jung Min Lee, Geeho Min, Jae Min Lee, Seung Han Kim, Hyuk Soon Choi, Eun Sun Kim, Bora Keum, Yoon Tae Jeen, Hoon Jai Chun, Hong Sik Lee, Chang Duck Kim, Jong-Jae Park, Beom Jae Lee, Seong Ji Choi, Woojung Kim
BACKGROUND AND AIMS: Recent studies have shown that etomidate is associated with fewer serious adverse events than propofol and has a noninferior sedative effect. We investigated whether etomidate-midazolam is associated with fewer cardiopulmonary adverse events and has noninferior efficacy compared to propofol-midazolam for screening colonoscopy in the elderly. METHODS: A prospective, single-center, double-blinded, randomized controlled trial was performed. Patients aged over 65 years who were scheduled to undergo screening colonoscopy were randomized to receive either etomidate or propofol based on midazolam...
May 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29767821/formative-research-on-knowledge-and-preferences-for-stool-based-tests-compared-to-colonoscopy-what-patients-and-providers-think
#12
John S Luque, Kristin Wallace, Bridgette F Blankenship, Lydia G Roos, Frank G Berger, Nancy R LaPelle, Cathy L Melvin
The rates of colorectal cancer (CRC) screening in the U.S. remain below national targets, so many people at risk are not being screened. The objective of this qualitative research project was to assess patient and provider knowledge and preferences about CRC screening modalities and specifically the use of the fecal immunochemical test (FIT) as a first line screening choice. Nine focus groups were conducted with a medically underserved patient population and qualitative interviews were administered to their medical providers...
May 16, 2018: Journal of Community Health
https://www.readbyqxmd.com/read/29767287/screening-for-comorbid-conditions-in-patients-enrolled-in-the-soda-registry-a-2-year-observational-analysis
#13
Whitney W Woodmansee, Murray B Gordon, Mark E Molitch, Adriana G Ioachimescu, Don W Carver, Beloo Mirakhur, David Cox, Roberto Salvatori
PURPOSE: This 2-year analysis assessed frequency of comorbidities and comorbidity screening in the Somatuline® (lanreotide, LAN) Depot for Acromegaly (SODA) registry. METHODS: Patient data collected included pituitary hormone deficiencies, sleep studies, echocardiograms, gallbladder sonographies, colonoscopies, and glycated hemoglobin (HbA1c) levels. Insulin-like growth factor-1 (IGF-1) and growth hormone levels in patients with (DM) and without (non-DM) diabetes mellitus were analyzed...
May 16, 2018: Endocrine
https://www.readbyqxmd.com/read/29766314/metastatic-colon-cancer-derived-from-a-diverticulum-incidentally-found-at-herniorrhaphy-a-case-report
#14
Jiro Kimura, Alan Kawarai Lefor, Shota Fukai, Kentaro Yoshikawa, Shingo Sasamatsu, Takashi Sakamoto, Ken Mizokami, Masaki Kanzaki, Tadao Kubota, Akira Saito, Hiroshi Izumi, Kunpei Honjo, Kunihiko Nagakari, Masaki Fukunaga
BACKGROUND: There are few reports of metastases from colon cancer to an inguinal hernia sac, and few reports of colon cancer originating in diverticula. We report a patient with carcinoma of the sigmoid colon arising in two diverticula, who presented with peritoneal seeding to an inguinal hernia sac, and a review of the literature. CASE PRESENTATION: A 55-year-old male underwent open herniorrhaphy for a left inguinal hernia. At operation, a nodule in the inguinal hernia sac was resected and histologic examination revealed adenocarcinoma, which was suspected to be a metastasis from a distant primary lesion...
May 15, 2018: Surgical Case Reports
https://www.readbyqxmd.com/read/29764845/endoscopic-diagnosis-of-a-goblet-cell-carcinoid-tumour-of-the-appendix
#15
Vanessa Falk, Marcia Ballantyne, Sergio Zepeda-Gómez, Ali Kohansal-Vajargah
Primary malignancies of the appendix are rare. Of these, less than 5% are goblet cell carcinoid (GCC) tumours. The majority of GCC present with findings of acute appendicitis or advanced peritoneal spread. We describe a rare presentation of GCC as subtle mucosal abnormality of the appendiceal orifice seen on colonoscopy performed for iron-deficiency anaemia. Biopsies were interpreted as adenocarcinoma; however, final surgical pathology confirmed GCC of the appendix with caecal involvement. The patient recovered well from surgery, anaemia resolved and follow-up did not show metastatic disease...
May 15, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29764832/large-bowel-obstruction-in-a-27-year-old-woman-caused-by-a-sigmoid-faecal-bolus
#16
Radford Arran James Smith, Muhammad Abdalkoddus, Robert Bethune
A 27-year-old woman presented to the emergency department with a 24-hour history of severe left iliac fossa pain associated with vomiting. She reported a history of ovarian cysts and was provisionally diagnosed with a ruptured ovarian cyst and admitted under the obstetrics and gynaecology team for further investigation. 24 hours later, she became haemodynamically unstable with increasing abdominal distention and developed a metabolic acidosis. A CT scan revealed large bowel obstruction (LBO) secondary to a faecal bolus in the sigmoid colon with appearances suggestive of adult-onset Hirschsprung's disease...
May 14, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29763272/colorectal-cancer-screening-and-prevention
#17
Thad Wilkins, Danielle McMechan, Asif Talukder
Colorectal cancer is a common cause of morbidity and mortality in the United States. Most colorectal cancers arise from preexisting adenomatous or serrated polyps. The incidence and mortality of colorectal cancer can be reduced with screening of average-risk adults 50 to 75 years of age. Randomized controlled trials show evidence of reduced colorectal cancer-specific mortality with guaiac-based fecal occult blood tests and flexible sigmoidoscopy. There are no randomized controlled trials on the effectiveness of colonoscopy to reduce colorectal cancer-specific mortality; however, several randomized controlled trials comparing colonoscopy with other strategies are in progress...
May 15, 2018: American Family Physician
https://www.readbyqxmd.com/read/29761359/ct-colonography-size-reduction-of-submerged-colorectal-polyps-due-to-electronic-cleansing-and-ct-window-settings
#18
Christian Bräuer, Philippe Lefere, Stefaan Gryspeerdt, Helmut Ringl, Ali Al-Mukhtar, Paul Apfaltrer, Dominik Berzaczy, Barbara Füger, Julia Furtner, Christina Müller-Mang, Matthias Pones, Martina Scharitzer, Ramona Woitek, Anno Graser, Michael Weber, Thomas Mang
OBJECTIVES: To assess whether electronic cleansing (EC) of tagged residue and different computed tomography (CT) windows influence the size of colorectal polyps in CT colonography (CTC). METHODS: A database of 894 colonoscopy-validated CTC datasets of a low-prevalence cohort was retrospectively reviewed to identify patients with polyps ≥6 mm that were entirely submerged in tagged residue. Ten radiologists independently measured the largest diameter of each polyp, two-dimensionally, before and after EC in colon, bone, and soft-tissue-windows, in randomised order...
May 14, 2018: European Radiology
https://www.readbyqxmd.com/read/29757376/the-role-of-perceived-benefits-and-barriers-in-colorectal-cancer-screening-in-intervention-trials-among-african-americans
#19
Randi M Williams, Thomas Wilkerson, Cheryl L Holt
The Health Belief Model (HBM) is widely used in health behavior interventions. The lack of diverse samples in the development of this theory warrants additional study on how it performs among minorities. While studies have utilized HBM to address colorectal cancer (CRC) screening, limited information exists confirming how these constructs influence screening. Data from three CRC screening trials were used to examine how perceived benefits/barriers perform among African Americans (AA) and whether they serve as mechanisms of the intervention effects on screening...
May 10, 2018: Health Education Research
https://www.readbyqxmd.com/read/29756684/a-prospective-bottom-up-study-of-the-costs-of-faecal-incontinence-in-ambulatory-patients
#20
Vicki Patton, Katrina Parkin, Kate H Moore
BACKGROUND AND AIM: The few studies that have examined direct costs of faecal incontinence are limited in that they employed retrospective databases, postal surveys, and focused upon institutionalised patients or post partum women. The aim of the current study was to identify the direct pre-treatment costs of faecal incontinence expended by a range of home dwelling patients and identify relationships between costs and severity of incontinence. METHODS: Consecutive patients attending an outpatient clinic for treatment of faecal incontinence were interviewed using a questionnaire, modeled on the Dowel Bryant Incontinence Cost Index...
May 14, 2018: Neurourology and Urodynamics
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