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One Health

Money Gupta, Rashi Chauhan, Yamuna Prasad, Gulshan Wadhwa, Chakresh Kumar Jain
The lack of complete treatments and appearance of multiple drug-resistance strains of Burkholderia cepacia complex (Bcc) are causing an increased risk of lung infections in cystic fibrosis patients. Bcc infection is a big risk to human health and demands an urgent need to identify new therapeutics against these bacteria. Network biology has emerged as one of the prospective hope in identifying novel drug targets and hits. We have applied protein-protein interaction methodology to identify new drug-target candidates (orthologs) in Burkhloderia cepacia GG4, which is an important strain for studying the quorum-sensing phenomena...
October 8, 2016: Computational Biology and Chemistry
Mohammadhossein Hajiebrahimi, Scott Montgomery, Sarah Burkill, Shahram Bahmanyar
OBJECTIVE: To investigate risk of premenopausal and postmenopausal breast cancer among Multiple Sclerosis (MS) patients, considering tumor stage. METHODS: The Swedish Patient Register identified 19,330 women with MS between 1968 and 2012, matched individually with a cohort of 193,458 without MS. Matching variables were year of birth, sex, region of residence and vital status at the time of diagnosis. The cancer register identified 471 and 5,753 breast cancer cases among the MS and non-MS cohorts, respectively...
2016: PloS One
Titia F Beek, Peggy T Cohen-Kettenis, Walter P Bouman, Annelou L C de Vries, Thomas D Steensma, Gemma L Witcomb, Jon Arcelus, Christina Richards, Els Elaut, Baudewijntje P C Kreukels
The World Health Organization (WHO) is currently updating the tenth version of their diagnostic tool, the International Classification of Diseases (ICD, WHO, 1992). Changes have been proposed for the diagnosis of Transsexualism (ICD-10) with regard to terminology, placement and content. The aim of this study was to gather the opinions of transgender individuals (and their relatives/partners) and clinicians in the Netherlands, Flanders (Belgium) and the United Kingdom regarding the proposed changes and the clinical applicability and utility of the ICD-11 criteria of 'Gender Incongruence of Adolescence and Adulthood' (GIAA)...
2016: PloS One
Thanh Tam Tran, Joel Adams-Bedford, Vasoontara Yiengprugsawan, Sam-Ang Seubsman, Adrian Sleigh
INTRODUCTION: Injury and psychological distress are public health priorities because of their high occurrence in the population. This study examines the longitudinal effects of injury characteristics on psychological distress. METHODS: Study participants were enrolled distance learning Thai adults (N = 42,785 at 2013 follow-up) residing nationwide. We analysed 2009 and 2013 data. Injury questions included injury prevalence, causes and levels of severity. Distress was measured using the standard Kessler-6...
2016: PloS One
Samuel A Sakyi, Samuel Yaw Aboagye, Isaac Darko Otchere, Albert M Liao, Thomas G Caltagirone, Dorothy Yeboah-Manu
BACKGROUND: Buruli ulcer (BU) is a subcutaneous skin disease listed among the neglected tropical diseases by the World Health Organization (WHO). Early case detection and management is very important to reduce morbidity and the accompanied characteristic disfiguring nature of BU. Since diagnosis based on clinical evidence can lead to misdiagnosis, microbiological confirmation is essential to reduce abuse of drugs; since the anti-mycobacterial drugs are also used for TB treatment. The current WHO gold standard PCR method is expensive, requires infrastructure and expertise are usually not available at the peripheral centers where BU cases are managed...
October 2016: PLoS Neglected Tropical Diseases
(no author information available yet)
Checklists are used in medical and nonmedical settings as cognitive aids to ensure that users complete all the items associated with a particular task. They are ideal for tasks with many steps, for tasks performed under stressful circumstances, or for reminding people to perform tasks that they are not routinely accustomed to doing. In medicine, they are ideal for promoting standardized processes of care in situations in which variation in practice may increase patient risk and the chance of medical errors...
November 2016: Obstetrics and Gynecology
(no author information available yet)
Checklists are used in medical and nonmedical settings as cognitive aids to ensure that users complete all the items associated with a particular task. They are ideal for tasks with many steps, for tasks performed under stressful circumstances, or for reminding people to perform tasks that they are not routinely accustomed to doing. In medicine, they are ideal for promoting standardized processes of care in situations in which variation in practice may increase patient risk and the chance of medical errors...
November 2016: Obstetrics and Gynecology
Peter J Stasikelis, Aaron T Creek, Linda I Wack
BACKGROUND: The purpose of this study is to examine the frequency of complications in children with myelodysplasia (MD) undergoing tibial rotational osteotomies with a matched cohort of children with cerebral palsy (CP). It was postulated that because of the unique health issues facing children with MD more complications would be observed. METHODS: A retrospective chart review was performed to identify children with MD who underwent primary tibial rotational osteotomy between 1997 and 2012 and had a minimum 2-year follow-up...
October 21, 2016: Journal of Pediatric Orthopedics
Hyung Nam Kim, Tami H Wyatt, Xueping Li, Mark Gaylord
Although parents of premature infants experience many challenges when transitioning home from the neonatal intensive care unit, healthcare providers and social support systems tend to focus on mothers and infants rather than fathers. Unfortunately, very little is known about paternal concerns and needs as compared with maternal ones. The lack of understanding about paternal needs may lead to inadequate designs of neonatal intensive care unit family support programs with less involved fathers, all of which contribute to increased burdens on mothers and poor health outcomes for their infants...
October 2016: Journal of Perinatal & Neonatal Nursing
Omair Atiq, Jasmin Tiro, Adam C Yopp, Adam Muffler, Jorge A Marrero, Neehar D Parikh, Caitlin Murphy, Katharine McCallister, Amit G Singal
: Although surveillance ultrasound and alpha fetoprotein (AFP) have minimal direct harm, downstream harms from follow-up tests must be weighed against surveillance benefits when determining the value of hepatocellular carcinoma (HCC) screening programs. Our study's aims were to characterize prevalence and correlates of surveillance benefits and harms in cirrhosis patients undergoing HCC surveillance. We conducted a retrospective cohort study among patients with cirrhosis followed at a safety-net health system between July 2010 and July 2013...
October 24, 2016: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
J Liu, H Yang, B Yu
OBJECTIVE: The objective of the present study was to determine the correlation between blood calcium level, hematoma volume and stroke severity in the prognosis of acute cerebral hemorrhage patients. PATIENTS AND METHODS: We selected 125 patients with acute cerebral hemorrhage admitted within 24 hours of symptom onset. Blood calcium levels were assessed by standard biochemical methods. Hematoma volume was measured by quantitative computed tomography. NIHSS (National Institutes of Health Stroke Scale) scores at one month, and the differences in survival rate and survival period at follow-up visits were assessed...
October 2016: European Review for Medical and Pharmacological Sciences
Gordon Gong, Cassandra C Huey, Coleman Johnson, Debra Curti, Billy U Philips
One of the goals of the Affordable Care Act aims to provide affordable health insurance through the health insurance exchange marketplace (the Marketplace). This study explores enrollments in the Marketplace in Texas and in rural vs urban areas in the East, South, and West regions of the state. Data are derived from the US Census Bureau and the Department of Health and Human Services. A total of 92.7% of eligible non-elderly adult Texans (NEATs) had enrolled in Marketplace insurance as of February 2015. Rural residents were less likely than urban residents to use the Marketplace...
October 1, 2016: Texas Medicine
Erin Hawkins, Susan Gathercole, Duncan Astle, The Calm Team, Joni Holmes
Symptoms of inattention and hyperactivity frequently co-occur with language difficulties in both clinical and community samples. We explore the specificity and strength of these associations in a heterogeneous sample of 254 children aged 5 to 15 years identified by education and health professionals as having problems with attention, learning and/or memory. Parents/carers rated pragmatic and structural communication skills and behaviour, and children completed standardised assessments of reading, spelling, vocabulary, and phonological awareness...
October 21, 2016: Brain Sciences
Mariangela Marrelli, Filomena Conforti, Fabrizio Araniti, Giancarlo A Statti
Obesity is one of the greatest public health problems. This complex condition has reached epidemic proportions in many parts of the world, and it constitutes a risk factor for several chronic disorders, such as hypertension, cardiovascular diseases and type 2 diabetes. In the last few decades, several studies dealt with the potential effects of natural products as new safe and effective tools for body weight control. Saponins are naturally-occurring surface-active glycosides, mainly produced by plants, whose structure consists of a sugar moiety linked to a hydrophobic aglycone (a steroid or a triterpene)...
October 20, 2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Marion Fiorentino, Edwige Landais, Guillaume Bastard, Alicia Carriquiry, Frank T Wieringa, Jacques Berger
Due to rapid urbanization and high food prices and in the absence of nutrition programs, school children from urban areas in West Africa often have insufficient and inadequate diet leading to nutrient deficiencies that affect their health and schooling performance. Acute malnutrition and micronutrient deficiencies are prevalent in children from primary state schools of Dakar (Senegal). The objectives of the present study were to assess the overall diet of these children, to report insufficient/excessive energy and nutrient intakes and to investigate association between insufficient nutrient intake and micronutrient deficiencies...
October 20, 2016: Nutrients
Ye Chang, Yuan Li, Xiaofan Guo, Dongxue Dai, Yingxian Sun
In 2010, the American Heart Association has proposed a new concept "ideal cardiovascular health" (CVH) based on seven CVH metrics: smoking, body mass index, physical activity, diet score, total cholesterol, blood pressure, and fasting plasma glucose. We aimed to determine the association of CVH with atherogenic index of plasma (AIP), a strong marker for atherosclerosis (AS). This cross-sectional study was conducted in the rural areas of northeast China and 11,113 middle-aged subjects were enrolled. Seven CVH metrics were classified into ideal, intermediate, and poor groups...
October 19, 2016: International Journal of Environmental Research and Public Health
César González-Ramírez, Jesús Montanero-Fernández, Diego Peral-Pacheco
BACKGROUND: The extreme variability of Temporary disability duration causes a deep impact in Public Health. We try to understand what factors does duration of disability depend on. METHODS: Through cohort study with data of temporal disabilities collected by Ibermutuamur from 2008 to 2012, we use statistical multivariate methods. RESULTS: The most reliable and convenient algorithm to predict duration was a categorical classification tree that distinguished between brief and long disabilities, taking into account both medical-biological and socioeconomic factors...
October 24, 2016: Archives of Environmental & Occupational Health
Daniel Berglind, Lena Hansson, Per Tynelius, Finn Rasmussen
BACKGROUND: Levels of physical activity (PA) affect health already at four years of age. The aims of this study were to describe levels and patterns of PA and sedentary time (ST) in a sample of four-year-old Swedish children and to assess the number of children achieving PA guidelines throughout the week. METHODS: Data from 540 four-year old children enrolled in the population-based PRIMROSE trial was used. PA was measured for a period of one week by the Actigraph GT3X+ accelerometer...
October 24, 2016: Journal of Physical Activity & Health
Catherine E Mosher, Rebecca N Adams, Paul R Helft, Bert H O'Neil, Safi Shahda, Nicholas A Rattray, Victoria L Champion
OBJECTIVE: This study assessed positive changes in patients with advanced colorectal cancer and their family caregivers following diagnosis. We compared self-reported positive changes within patient-caregiver dyads as well as self-reports and patient reports of positive changes in caregivers. DESIGN: Individual, semi-structured qualitative interviews were conducted with 23 patients with advanced colorectal cancer and 23 caregivers. A theoretical thematic analysis of interview transcripts was framed by posttraumatic growth theory...
October 24, 2016: Psychology & Health
Matthew Blake, Joanna M Waloszek, Orli Schwartz, Monika Raniti, Julian G Simmons, Laura Blake, Greg Murray, Ronald E Dahl, Richard Bootzin, Paul Dudgeon, John Trinder, Nicholas B Allen
Objective: Sleep problems are a major risk factor for the emergence of mental health problems in adolescence. The aim of this study was to investigate the post intervention effects of a cognitive-behavioral/mindfulness-based group sleep intervention on sleep and mental health among at-risk adolescents. Method: A randomized controlled trial (RCT) was conducted across High schools in Melbourne, Australia. One hundred forty-four adolescents (aged 12-17 years) with high levels of anxiety and sleeping difficulties, but without past or current depressive disorder, were randomized into either a sleep improvement intervention or an active control 'study skills' intervention...
October 24, 2016: Journal of Consulting and Clinical Psychology
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