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https://www.readbyqxmd.com/read/29471590/consumer-use-and-response-to-online-third-party-raw-dna-interpretation-services
#1
Catharine Wang, Tiernan J Cahill, Andrew Parlato, Blake Wertz, Qiankun Zhong, Tricia Norkunas Cunningham, James J Cummings
BACKGROUND: With the availability of raw DNA generated from direct-to-consumer (DTC) testing companies, there has been a proliferation of third-party online services that are available to interpret the raw data for both genealogy and/or health purposes. This study examines the current landscape and downstream clinical implications of consumer use of third-party services. METHODS: Study participants were recruited online from social media platforms. A total of 321 survey respondents reported using third-party services for raw DNA interpretation...
January 2018: Molecular Genetics & Genomic Medicine
https://www.readbyqxmd.com/read/29471491/farming-characteristics-and-self-reported-health-outcomes-of-irish-farmers
#2
D van Doorn, N Richardson, A Storey, A Osborne, C Cunningham, C Blake, J McNamara
Background: Irish farmers represent a 'high-risk' group for non-communicable diseases, which, arguably, pose a greater occupational health challenge for farmers. To date, there has been little exploration of the farming characteristics associated with farmers' poor health outcomes. Aims: To examine the relationship between farming and male farmers' self-reported health outcomes and to compare the study findings to national health studies to explore which factors specifically are associated with Irish farmers' poorer health outcomes relative to the general population...
February 17, 2018: Occupational Medicine
https://www.readbyqxmd.com/read/29471438/development-of-a-health-assessment-instrument-for-people-with-intellectual-disabilities-a-delphi-study
#3
Esther J Bakker-van Gijssel, Peter L B J Lucassen, Tim C Olde Hartman, Willem J J Assendelft, Henny M J van Schrojenstein Lantman-de Valk
Background: People with intellectual disabilities (IDs) experience health inequalities. Applying health assessments is one way of diminishing these inequalities. A health assessment instrument can support general practitioners (GPs) in providing better medical care to people with ID. Objectives: The aim of this study was to determine which items should be part of a health assessment instrument for people with ID to be used in primary care. Methods: This Delphi consensus study was conducted among 24 GP experts and 21 ID physicians...
February 17, 2018: Family Practice
https://www.readbyqxmd.com/read/29471397/a-conceptual-framework-the-musical-self-as-a-unique-pathway-to-outcomes-in-the-acute-pediatric-health-setting
#4
Helen Shoemark, Jo Rimmer, Janeen Bower, Belinda Tucquet, Lauren Miller, Michelle Fisher, Nicholas Ogburn, Beth Dun
This article reports on a project at the Royal Children's Hospital Melbourne in which the music therapy team synthesized their practice and related theories to propose a new conceptual framework for music therapy in their acute pediatric setting. The impetus for the project was the realization that in the process of producing key statements about the non-musical benefits of music therapy, the cost was often the suppression of information about the patient's unique musical potential as the major (mediating) pathway from referral reason, to music therapy, and to effective outcomes...
February 17, 2018: Journal of Music Therapy
https://www.readbyqxmd.com/read/29471351/viability-of-campylobacter-spp-in-frozen-and-chilled-broiler-carcasses-according-to-real-time-pcr-with-propidium-monoazide-pretreatment
#5
Andréa G S A Castro, Elaine M S Dorneles, Ethiene L S Santos, Telma M Alves, Guilherme R Silva, Tadeu C Figueiredo, Débora C S Assis, Andrey P Lage, Silvana V Cançado
The aim of this study was to evaluate the viability of Campylobacter spp. in frozen and chilled broiler carcasses using real-time PCR with propidium monoazide (PMA) pretreatment. Sixty broiler carcasses were collected: 30 frozen and 30 chilled. Each carcass was submitted to 2 real-time PCR protocols to detect and quantify Campylobacter spp.: one using pretreatment with PMA, which blocks the amplification of DNA from dead bacteria, and the other without PMA. The results showed that PMA-pretreated carcasses, either frozen or chilled, had a lower positivity rate compared to untreated samples (P < 0...
February 19, 2018: Poultry Science
https://www.readbyqxmd.com/read/29471329/effects-of-varenicline-depressive-symptoms-and-region-of-enrollment-on-smoking-cessation-in-depressed-smokers
#6
Neal Doran, Sarah Dubrava, Robert M Anthenelli
Introduction: Despite effective treatments, relapse to smoking remains a vexing global health problem. One predictor of relapse is depressive symptoms. Medications such as varenicline reduce withdrawal-related symptoms of depression, reducing relapse. This study examined whether varenicline moderated the effect of depressive symptoms on relapse, and whether this varied by region of enrollment. Methods: Adult smokers (n=525; 37% male) with past or current, stable major depressive disorder recruited from US (n=255), and European (n=270) sites participated in a randomized, double-blind cessation treatment trial including 12 weeks of varenicline or placebo, with 40-week non-treatment follow-up...
February 17, 2018: Nicotine & Tobacco Research: Official Journal of the Society for Research on Nicotine and Tobacco
https://www.readbyqxmd.com/read/29471292/step-numbers-and-hoehn-yahr-stage-after-six-years
#7
Hiroshi Kataoka, Noriyuki Tanaka, Takao Kiriyama, Nobuyuki Eura, Masanori Ikeda, Tesseki Izumi, Yoshiko Furiya, Kazuma Sugie, Satoshi Ueno
BACKGROUND: Freezing of gait (FOG) has been linked to increased numbers of steps taken while walking. We tested the hypothesis that an increased number of steps associated with FOG might predict the exacerbation of the severity of Parkinson's disease (PD). METHODS: We prospectively studied 26 patients. Clinical assessments were performed and balance was evaluated in 30 patients with Hoehn-Yahr stage III PD 6 years previously. Gait parameters were analyzed with the use of an originally designed, suddenly narrowed path...
February 22, 2018: European Neurology
https://www.readbyqxmd.com/read/29471284/adverse-metabolic-effects-in-fish-exposed-to-contaminants-of-emerging-concern-in-the-field-and-laboratory
#8
James P Meador, Andrew Yeh, Evan P Gallagher
Several metabolic parameters were assessed in juvenile Chinook salmon (Oncorhynchus tshawytscha) and staghorn sculpin (Leptocottus armatus) residing in two estuaries receiving wastewater treatment effluent and one reference estuary. We also conducted a laboratory study with fish dosed for 32 days with 16 of the most common contaminants of emerging concern (CECs) detected in feral fish. Several blood chemistry parameters and other indicators of health were measured in fish from the field and laboratory study that were used to assess potential metabolic disruption...
February 19, 2018: Environmental Pollution
https://www.readbyqxmd.com/read/29471256/consensus-research-priorities-for-paediatric-status-epilepticus-a-delphi-study-of-health-consumers-researchers-and-clinicians
#9
Jeremy Furyk, Robin Ray, Kerriane Watt, Stuart R Dalziel, Ed Oakely, Mark Mackay, Gabriel Dabscheck, Kate Riney, Franz E Babl
PURPOSE: Status epilepticus (SE) is a paediatric emergency with significant morbidity and mortality. Recommendations beyond first line care are not based on high quality evidence. Emergency physicians and neurologists are key stakeholders in managing this condition. A collaborative, widely consulted approach to identifying priorities can help direct limited research funds appropriately. The objectives of this study are to identify consensus research priorities in paediatric SE among experts and health consumers...
February 5, 2018: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/29471185/the-attention-training-technique-improves-children-s-ability-to-delay-gratification-a-controlled-comparison-with-progressive-relaxation
#10
Joanne Murray, Helen Scott, Claire Connolly, Adrian Wells
The ability to delay gratification at a young age is a predictor of psychological, cognitive, health, and academic later-life outcomes. This study aimed to extend earlier research and explore whether a metacognitive intervention, Wells' (1990) Attention Training Technique (ATT), could improve young children's ability to delay gratification compared to an active-control (Progressive Muscle Relaxation: PMR), and no-intervention group. One hundred and one children aged 5-6 years old were recruited from schools...
February 15, 2018: Behaviour Research and Therapy
https://www.readbyqxmd.com/read/29471182/the-impact-of-vitamin-a-supplementation-in-childhood-on-adult-outcomes-an-exploration-of-mechanisms-timing-of-exposure-and-heterogeneous-effects
#11
Yubraj Acharya
There is now a critical threshold of evidence documenting the relationship between one's exposure to shocks in early life and outcomes in adulthood. Using Nepal's vitamin A supplementation program, this study provides additional insights on the mechanisms and differences in effects by the timing of the first exposure and across different groups. The program's sequential rollout between 1993 and 2001 and the age eligibility provide an exogenous variation in exposure to the program. I utilize that variation and data on more than 700,000 individuals from the 2011 census to estimate the program's causal effect on long-term health and educational outcomes...
February 5, 2018: Social Science & Medicine
https://www.readbyqxmd.com/read/29471181/clinic-access-and-teenage-birth-rates-racial-ethnic-and-spatial-disparities-in-houston-tx
#12
Megan M Wisniewski, Heather A O'Connell
Teenage motherhood is a pressing issue in the United States, and one that is disproportionately affecting racial/ethnic minorities. In this research, we examine the relationship between the distance to the nearest reproductive health clinic and teenage birth rates across all zip codes in Houston, Texas. Our primary data come from the Texas Department of State Health Services. We use spatial regression analysis techniques to examine the link between clinic proximity and local teenage birth rates for all females aged 15 to 19, and separately by maternal race/ethnicity...
February 14, 2018: Social Science & Medicine
https://www.readbyqxmd.com/read/29470802/male-undergraduates-hpv-vaccination-behavior-implications-for-achieving-hpv-associated-cancer-equity
#13
Hee Yun Lee, Katherine Lust, Suzanne Vang, Jay Desai
Despite the availability of the human papillomavirus (HPV) vaccine for males, uptake of the vaccine has been low, particularly among young adult males. This study aimed to investigate the levels of HPV vaccination and predictors of HPV vaccine completion in college men ages 18-26. We analyzed data from the 2015 College Student Health Survey, which was administered at 17 post-secondary institutions in Midwest areas. We included only responses from male participants who were ages 18-26 years old, resulting in a sample size of 2516...
February 22, 2018: Journal of Community Health
https://www.readbyqxmd.com/read/29470789/evaluation-of-psychometric-and-linguistic-properties-of-the-italian-adolescent-pain-assessment-scales-a-systematic-review
#14
REVIEW
Flavio Marti, Antonella Paladini, Giustino Varrassi, Roberto Latina
INTRODUCTION: Adolescents' pain experiences are complex and multidimensional, and evaluating pain only from a sensory and affective point of view may be in many instances limiting and inadequate; this is the reason why it is of paramount importance to identify the tools which can better assess the pain experienced by young patients. A person-oriented approach is highly encouraged, as it may better investigate the cognitive and behavioral development typical of this age group. The aim of this review paper is to describe the available tools which are able to adequately assess pain intensity in adolescents, in particular those validated in Italian...
February 22, 2018: Pain and Therapy
https://www.readbyqxmd.com/read/29470775/influence-of-body-mass-index-in-anti-m%C3%A3-llerian-hormone-levels-in-951-non-polycystic-ovarian-syndrome-women-followed-at-a-reproductive-medicine-unit
#15
Joana Simões-Pereira, Joaquim Nunes, Ana Aguiar, Sandra Sousa, Cátia Rodrigues, Joaquim Sampaio Matias, Carlos Calhaz-Jorge
PURPOSE: Anti-Müllerian hormone (AMH) is a useful marker of ovarian reserve. Obesity/overweight are increasing and may affect the reproductive health. Previous studies regarding the effect of body mass index (BMI) on AMH levels are discordant. Our main goal was to evaluate the influence of BMI on AMH levels in women without polycystic ovarian syndrome. METHODS: Revision of medical records of 951 women who performed AMH determinations as part of their fertility workup, between 2011 and 2016...
February 22, 2018: Endocrine
https://www.readbyqxmd.com/read/29470774/multi-indication-and-combination-pricing-and-reimbursement-of-pharmaceuticals-opportunities-for-improved-health-care-through-faster-uptake-of-new-innovations
#16
Ulf Persson, J M Norlin
Many pharmaceuticals are effective in multiple indications and the degree of effectiveness may differ. A product-based pricing and reimbursement system with a single price per product is insufficient to reflect the variable values between different indications. The objective of this article is to present examples of actual pricing and reimbursement decisions using current value-based pricing in Sweden and to discuss their implications and possible solutions. The value of several cancer drugs was estimated for various indications based on a willingness-to-pay threshold of 1 million SEK (EUR 104,000) per QALY gained...
February 22, 2018: Applied Health Economics and Health Policy
https://www.readbyqxmd.com/read/29470746/nitinol-stents-in-the-femoropopliteal-artery-a-mechanical-perspective-on-material-design-and-performance
#17
REVIEW
Kaspars Maleckis, Eric Anttila, Paul Aylward, William Poulson, Anastasia Desyatova, Jason MacTaggart, Alexey Kamenskiy
Endovascular stenting has matured into a commonly used treatment for peripheral arterial disease (PAD) due to its minimally invasive nature and associated reductions in short-term morbidity and mortality. The mechanical properties of the superelastic Nitinol alloy have played a major role in the explosion of peripheral artery stenting, with modern stents demonstrating reasonable resilience and durability. Yet in the superficial femoral and popliteal arteries, even the newest generation Nitinol stents continue to demonstrate clinical outcomes that leave significant room for improvement...
February 22, 2018: Annals of Biomedical Engineering
https://www.readbyqxmd.com/read/29470731/sacral-neuromodulation-versus-personalized-conservative-treatment-in-patients-with-idiopathic-slow-transit-constipation-study-protocol-of-the-no-2-trial-a-multicenter-open-label-randomized-controlled-trial-and-cost-effectiveness-analysis
#18
S C M Heemskerk, A H Rotteveel, M A Benninga, C I M Baeten, A A M Masclee, J Melenhorst, S M J van Kuijk, C D Dirksen, S O Breukink
PURPOSE: The evidence regarding the (cost-)effectiveness of sacral neuromodulation (SNM) in patients with therapy-resistant idiopathic slow-transit constipation is of suboptimal quality. The Dutch Ministry of Health, Welfare and Sports has granted conditional reimbursement for SNM treatment. The objective is to assess the effectiveness, cost-effectiveness, and budget impact of SNM compared to personalized conservative treatment (PCT) in patients with idiopathic slow-transit constipation refractory to conservative treatment...
February 22, 2018: International Journal of Colorectal Disease
https://www.readbyqxmd.com/read/29470596/mental-health-burden-in-a-national-sample-of-american-indian-and-alaska-native-adults-differences-between-multiple-race-and-single-race-subgroups
#19
Nancy L Asdigian, Ursula Running Bear, Janette Beals, Spero M Manson, Carol E Kaufman
PURPOSE: Research on American Indian and Alaska Native (AIAN) mental health disparities is based largely on either tribal populations or national samples of adults that do not account for multiracial AIANs, even though over 40% of AIANs identify with multiple racial groups. The present investigation extends this research by assessing mental health status in a national sample of multiracial AIAN adults relative to adults who identify exclusively as either AIAN or White. METHODS: 2012 BRFSS data were used to conduct multinomial logistic regression analyses comparing mental health outcomes among respondents who identified as either AIAN and one or more other races (AIAN-MR), AIAN-Single Race (AIAN-SR), or White-SR...
February 22, 2018: Social Psychiatry and Psychiatric Epidemiology
https://www.readbyqxmd.com/read/29470565/sociodemographic-medical-and-psychosocial-factors-associated-with-supportive-care-needs-in-adults-diagnosed-with-uveal-melanoma
#20
Timothy J Williamson, Alexandra Jorge-Miller, Tara A McCannel, Tammy M Beran, Annette L Stanton
Importance: Understanding supportive care needs in patients with cancer is important for developing approaches that enhance quality of life and promote satisfaction with care. Objective: To characterize the nature and frequency of sociodemographic, medical, and psychosocial factors associated with unmet needs in patients with uveal melanoma 1 week and 3 months after diagnosis. Design, Setting, and Participants: This 3-month, prospective, longitudinal survey study was conducted at a university-based ophthalmology practice from June 1, 2007, to July 1, 2011...
February 22, 2018: JAMA Ophthalmology
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