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https://www.readbyqxmd.com/read/28662230/vascular-adhesion-protein-1-blockade-suppresses-ocular-inflammation-after-retinal-laser-photocoagulation-in-mice
#1
Takashi Matsuda, Kousuke Noda, Miyuki Murata, Akiko Kawasaki, Atsuhiro Kanda, Yukihiko Mashima, Susumu Ishida
Purpose: To investigate the effect of the vascular adhesion protein-1 (VAP-1) inhibitor RTU-1096 on retinal morphologic changes and ocular inflammation after retinal laser photocoagulation in mice. Methods: C57BL/6JJcl mice were fed a diet containing RTU-1096, a specific inhibitor for VAP-1, or a control diet ad libitum for 7 days. Laser photocoagulation was performed on the peripheral retina of the animals. The semicarbazide sensitive amine oxidase (SSAO) activities in plasma and chorioretinal tissues were measured...
June 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28627649/hypoxia-serves-a-key-function-in-the-upregulated-expression-of-vascular-adhesion-protein%C3%A2-1-in%C3%A2-vitro-and-in-a-rat-model-of-hemorrhagic-shock
#2
Yuxing Zhang, Wei Yi, Jun Yao, Xiaojun Yu, Cheng Qian, Zhiqian Hu
Hemorrhagic shock following major trauma results in mortality, but the function of vascular adhesion protein‑1 (VAP‑1), implicated in intracranial hemorrhage, remains unknown. This study aimed to determine whether expression of the AOC3 gene and its encoded protein, VAP‑1, is altered by hypoxia. Rat hepatic sinusoidal endothelial cells (RHSECs) and rat intestinal microvascular endothelial cells (RIMECs) were transduced with a viral vector carrying AOC3, and AOC3 mRNA expression levels were measured by reverse transcription‑quantitative polymerase chain reaction...
August 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28437839/inhibition-of-semicarbazide-sensitive-amine-oxidase-vascular-adhesion-protein-1-reduces-lipopolysaccharide-induced-neuroinflammation
#3
Serena Becchi, Alberto Buson, Jonathan Foot, Wolfgang Jarolimek, Bernard W Balleine
BACKGROUND AND PURPOSE: Neuroinflammation is initiated by a variety of stimuli including infections, sepsis, neurodegenerative diseases or traumatic brain injury and, if not adequately controlled, can lead to various degrees of neuronal damage and behavioural impairment. A critical event in the initial steps of inflammation is neutrophil extravasation. Semicarbazide-sensitive amine oxidase (SSAO, also known as vascular adhesion protein 1 or VAP-1) regulates neutrophil adhesion and extravasation...
July 2017: British Journal of Pharmacology
https://www.readbyqxmd.com/read/28435530/small-molecule-lysyl-oxidase-like-2-loxl2-inhibitors-the-identification-of-an-inhibitor-selective-for-loxl2-over-lox
#4
John H Hutchinson, Martin W Rowbottom, David Lonergan, Janice Darlington, Pat Prodanovich, Christopher D King, Jilly F Evans, Gretchen Bain
Two series of novel LOXL2 enzyme inhibitors are described: benzylamines substituted with electron withdrawing groups at the para-position and 2-substituted pyridine-4-ylmethanamines. The most potent compound, (2-chloropyridin-4-yl)methanamine 20 (hLOXL2 IC50 = 126 nM), was shown to be selective for LOXL2 over LOX and three other amine oxidases (MAO-A, MAO-B, and SSAO). Compound 20 is the first published small molecule inhibitor selective for LOXL2 over LOX.
April 13, 2017: ACS Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/28409494/association-between-metabolically-healthy-central-obesity-in-women-and-levels-of-soluble-receptor-for-advanced-glycation-end-products-soluble-vascular-adhesion-protein-1-and-the-activity-of-semicarbazide-sensitive-amine-oxidase
#5
Ivana Koborová, Radana Gurecká, Melinda Csongová, Katarína Volkovová, Éva Szökő, Tamás Tábi, Katarína Šebeková
AIM: To determine the levels of circulating soluble receptor for advanced glycation end products (sRAGE), as a biomarker of risk of metabolic syndrome and cardiovascular disease development in centrally obese (CO) women considered metabolically healthy (COH) in comparison with those metabolically unhealthy (COU). METHODS: 47 lean healthy, 17 COH (presenting waist-to-height ratio ≥0.5 but not elevated blood pressure, atherogenic lipid profile, and insulin resistance), and 50 COU (CO presenting ≥2 risk factors) women aged 40-45 years were included...
April 14, 2017: Croatian Medical Journal
https://www.readbyqxmd.com/read/28228728/perivascular-adipose-tissue-s-impact-on-norepinephrine-induced-contraction-of-mesenteric-resistance-arteries
#6
Nadia Ayala-Lopez, Janice M Thompson, Stephanie W Watts
Background: Perivascular adipose tissue (PVAT) can decrease vascular contraction to NE. We tested the hypothesis that metabolism and/or uptake of vasoactive amines by mesenteric PVAT (MPVAT) could affect NE-induced contraction of the mesenteric resistance arteries. Methods: Mesenteric resistance vessels (MRV) and MPVAT from male Sprague-Dawley rats were used. RT-PCR and Western blots were performed to detect amine metabolizing enzymes. The Amplex® Red Assay was used to quantify oxidase activity by detecting the oxidase reaction product H2O2 and the contribution of PVAT on the mesenteric arteries' contraction to NE was measured by myography...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28067251/analgesic-and-anti-inflammatory-effects-of-the-novel-semicarbazide-sensitive-amine-oxidase-inhibitor-szv-1287-in-chronic-arthritis-models-of-the-mouse
#7
Ádám Horváth, Awt Menghis, Bálint Botz, Éva Borbély, Ágnes Kemény, Valéria Tékus, Janka Zsófia Csepregi, Attila Mócsai, Tamás Juhász, Róza Zákány, Dóra Bogdán, Péter Mátyus, Julie Keeble, Erika Pintér, Zsuzsanna Helyes
Semicarbazide-sensitive amine oxidase (SSAO) catalyses oxidative deamination of primary amines. Since there is no data about its function in pain and arthritis mechanisms, we investigated the effects of our novel SSAO inhibitor SzV-1287 in chronic mouse models of joint inflammation. Effects of SzV-1287 (20 mg/kg i.p./day) were investigated in the K/BxN serum-transfer and complete Freund's adjuvant (CFA)-evoked active immunization models compared to the reference SSAO inhibitor LJP-1207. Mechanonociception was assessed by aesthesiometry, oedema by plethysmometry, clinical severity by scoring, joint function by grid test, myeloperoxidase activity by luminescence, vascular leakage by fluorescence in vivo imaging, histopathological changes by semiquantitative evaluation, and cytokines by Luminex assay...
January 9, 2017: Scientific Reports
https://www.readbyqxmd.com/read/27802225/urine-formaldehyde-predicts-cognitive-impairment-in-post-stroke-dementia-and%C3%A2-alzheimer-s-disease
#8
Zhiqian Tong, Weishan Wang, Wenhong Luo, Jihui Lv, Hui Li, Hongjun Luo, Jianping Jia, Rongqiao He
Although Alzheimer's disease (AD) was first described over 100 years ago, there is still no suitable biomarker for diagnosing AD in easily collectable samples (e.g., blood plasma, saliva, and urine). Here, we investigated the relationship between morning urine formaldehyde concentration and cognitive impairment in patients with post-stroke dementia (PSD) or AD in this cross-sectional survey for 7 years. Cognitive abilities of the study participants (n = 577, four groups: 231 controls, 61 stroke, 65 PSD, and 220 AD) were assessed by Mini-Mental State Examination (MMSE)...
2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/27766585/anatomical-distribution-of-primary-amine-oxidase-activity-in-four-adipose-depots-and-plasma-of-severely-obese-women-with-or-without-a-dysmetabolic-profile
#9
Christian Carpéné, Francisco Les, Mounia Hasnaoui, Simon Biron, Picard Marceau, Denis Richard, Jean Galitzky, Denis R Joanisse, Pascale Mauriège
Semicarbazide-sensitive amine oxidase (SSAO), identical to primary amine oxidase or vascular adhesion protein-1, is a membrane enzyme that generates hydrogen peroxide. SSAO is highly expressed at the adipocyte surface, and its plasma levels increase with type 2 diabetes. Since visceral adipose tissue (AT) is more tightly associated with obesity complications than subcutaneous (SC) abdominal fat, we compared SSAO activity in plasma and 4 distinct AT locations in 48 severely obese women (body mass index (BMI), averaging 54 ± 11 kg/m(2)), with or without a dysmetabolic profile...
October 21, 2016: Journal of Physiology and Biochemistry
https://www.readbyqxmd.com/read/27699080/brain-formaldehyde-is-related-to-water-intake-behavior
#10
Ting Li, Tao Su, Yingge He, Jihui Lu, Weichuan Mo, Yan Wei, Rongqiao He
A promising strategy for the prevention of Alzheimer's disease (AD) is the identification of age-related changes that place the brain at risk for the disease. Additionally, AD is associated with chronic dehydration, and one of the significant changes that are known to result in metabolic dysfunction is an increase in the endogenous formaldehyde (FA) level. Here, we demonstrate that the levels of uric formaldehyde in AD patients were markedly increased compared with normal controls. The brain formaldehyde levels of wild-type C57 BL/6 mice increased with age, and these increases were followed by decreases in their drinking frequency and water intake...
October 2016: Aging and Disease
https://www.readbyqxmd.com/read/27495192/the-inhibitor-of-semicarbazide-sensitive-amine-oxidase-pxs-4728a-ameliorates-key-features-of-chronic-obstructive-pulmonary-disease-in-a-mouse-model
#11
A G Jarnicki, H Schilter, G Liu, K Wheeldon, A-T Essilfie, J S Foot, T T Yow, W Jarolimek, P M Hansbro
BACKGROUND AND PURPOSE: Chronic obstructive pulmonary disease (COPD) is a major cause of illness and death, often induced by cigarette smoking (CS). It is characterized by pulmonary inflammation and fibrosis that impairs lung function. Existing treatments aim to control symptoms but have low efficacy, and there are no broadly effective treatments. A new potential target is the ectoenzyme, semicarbazide-sensitive mono-amine oxidase (SSAO; also known as vascular adhesion protein-1). SSAO is elevated in smokers' serum and is a pro-inflammatory enzyme facilitating adhesion and transmigration of leukocytes from the vasculature to sites of inflammation...
November 2016: British Journal of Pharmacology
https://www.readbyqxmd.com/read/27475863/piceatannol-and-resveratrol-share-inhibitory-effects-on-hydrogen-peroxide-release-monoamine-oxidase-and-lipogenic-activities-in-adipose-tissue-but-differ-in-their-antilipolytic-properties
#12
Francisco Les, Simon Deleruyelle, Laure-Estelle Cassagnes, Jean A Boutin, Balázs Balogh, José M Arbones-Mainar, Simon Biron, Picard Marceau, Denis Richard, Françoise Nepveu, Pascale Mauriège, Christian Carpéné
Piceatannol is a hydroxylated derivative of resveratrol. While both dietary polyphenols coexist in edible plants and fruits, and share equivalent concentrations in several wines, the influence of piceatannol on adiposity has been less studied than that of resveratrol. Though resveratrol is now recognized to limit fat deposition in various obesity models, the benefit of its dietary supplementation remains under debate regarding human obesity treatment or prevention. The research for more potent resveratrol analogs is therefore still undergoing...
October 25, 2016: Chemico-biological Interactions
https://www.readbyqxmd.com/read/27300745/correlation-among-soluble-receptors-for-advanced-glycation-end-products-soluble-vascular-adhesion-protein-1-semicarbazide-sensitive-amine-oxidase-svap-1-and-cardiometabolic-risk-markers-in-apparently-healthy-adolescents-a-cross-sectional-study
#13
Radana Gurecká, Ivana Koborová, Melinda Csongová, Jozef Šebek, Katarína Šebeková
In non-diabetics, low levels of soluble receptor for advanced glycations end products (sRAGE) associate with an increased risk of development of diabetes, cardiovascular afflictions, or death. The majority of studies in non-diabetics report an inverse relationship between measures of obesity, cardiometabolic risk factors and sRAGE and/or endogenous secretory RAGE (esRAGE) levels. To elucidate whether this inconsistency is related to the metabolically healthy obese phenotype, or a different impact of the risk factors in presence and absence of obesity, we analyzed data from 2206 apparently healthy adolescents (51 % girls) aged 15-to-19 years...
August 2016: Glycoconjugate Journal
https://www.readbyqxmd.com/read/27133345/evidence-for-existence-of-thyroid-hormone-inducible-semicarbazide-sensitive-amine-oxidase-ssao-in-rat-heart-cytosol
#14
Toshio Obata, Michiko Nakashima
BACKGROUND: Semicarbazide-sensitive amine oxidase (SSAO; EC; 1.4.3.6.) has widespread tissue distribution, and the physiological role of SSAO is quite well known through its involvement in several pathological states. AIMS: The present study examined modulators of SSAO which might be present in the rat heart cytosol and looked for changes in SSAO modulatory activity. METHODS: An endogenous inhibitor of SSAO was separated by gel filtration from 105,000g supernate of T4-treated rat heart cytosol...
March 2016: Indian Heart Journal
https://www.readbyqxmd.com/read/27129976/hplc-uv-method-for-evaluation-of-inhibitors-of-plasma-amine-oxidase-using-derivatization-of-an-aliphatic-aldehyde-product-with-tris
#15
Kira Mergemeier, Matthias Lehr
Plasma amine oxidase (PAO), which is also designated as semicarbazide-sensitive amine oxidase (SSAO), copper-containing amine oxidase 3 (AOC3), or vascular adhesion protein-1 (VAP-1), catalyzes the oxidative deamination of primary amines to aldehydes using copper and a quinone as cofactors. Because it participates in the transmigration of inflammatory cells through the blood vessels into the tissue, PAO is attributed an important role in inflammatory diseases. Therefore, inhibitors of this enzyme could lead to new therapeutics for the treatment of inflammation-related conditions...
July 2016: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/27065245/inactivation-of-semicarbazide-sensitive-amine-oxidase-induces-the-phenotypic-switch-of-smooth-muscle-cells-and-aggravates-the-development-of-atherosclerotic-lesions
#16
Miao Zhang, Limin Liu, Feng Zhi, Panpan Niu, Mengya Yang, Xuemei Zhu, Ying Diao, Yanmei Li, Jun Wang, Ying Zhao
BACKGROUND AND AIMS: Clinical studies have demonstrated that serum semicarbazide-sensitive amine oxidase (SSAO) activities positively correlate with the progression of atherosclerosis. The aim of the present study is to investigate the effect of SSAO inactivation on the development of atherosclerosis. METHODS: Female LDLr knockout (KO) mice were given the Western-type diet for 6 and 9 weeks to induce the formation of early and advanced lesions, and semicarbazide (SCZ, 0...
June 2016: Atherosclerosis
https://www.readbyqxmd.com/read/27043821/inactivation-of-semicarbazide-sensitive-amine-oxidase-stabilizes-the-established-atherosclerotic-lesions-via-inducing-the-phenotypic-switch-of-smooth-muscle-cells
#17
Ya Peng, Jun Wang, Miao Zhang, Panpan Niu, Mengya Yang, Yilin Yang, Ying Zhao
Given that the elevated serum semicarbazide-sensitive amine oxidase (SSAO) activity is associated with the severity of carotid atherosclerosis in clinic, the current study aims to investigate whether SSAO inactivation by semicarbazide is beneficial for established atherosclerotic lesions in LDLr knockout mice on a high-fat/high- cholesterol Western-type diet or after dietary lipid lowering. Despite no impact on plasma total cholesterol levels, the infiltration of circulating monocytes into peripheral tissues, and the size of atherosclerotic lesions, abrogation of SSAO activity resulted in the stabilization of established lesions as evidenced by the increased collagen contents under both conditions...
2016: PloS One
https://www.readbyqxmd.com/read/26930003/a-novel-3-4-5-diphenyl-1-3-oxazol-2-yl-propanal-oxime-compound-is-a-potent-transient-receptor-potential-ankyrin-1-and-vanilloid-1-trpa1-and-v1-receptor-antagonist
#18
M Payrits, É Sághy, P Mátyus, A Czompa, R Ludmerczki, R Deme, Z Sándor, Zs Helyes, É Szőke
Transient Receptor Potential Ankyrin 1 and Vanilloid 1 (TRPA1, TRPV1) ion channels expressed on nociceptive primary sensory neurons are important regulators of pain and inflammation. TRPA1 is activated by several inflammatory mediators including formaldehyde and methylglyoxal that are products of the semicarbazide-sensitive amine-oxidase enzyme (SSAO). SZV-1287 is a new 3-(4,5-diphenyl-1,3-oxazol-2-yl)propanal oxime SSAO inhibitor, its chemical structure is similar to other oxime derivatives described as TRPA1 antagonists...
June 2, 2016: Neuroscience
https://www.readbyqxmd.com/read/26886786/identification-of-protein-complexes-of-microsomes-in-rat-adipocytes-by-native-gel-coupled-with-lc-esi-qtof
#19
Ming Ke, Yongqian Zhang, Yan Xiong, Yasmeen Saeed, Yulin Deng
The study of the composition of microsome proteins/complexes/interactions in adipocytes provides useful information for researchers related to energy metabolism disorders. The native gel coupled with LC-ESI-QTOF approach was employed here for separating protein complexes. We found a series of proteins functionally clustered in biological processes of protein metabolism, cellular carbohydrate catabolism, response to stimulus and wounding, macromolecular complex subunit organization, positive regulation of molecular function, regulation of programmed cell death and biomolecule transport...
April 2016: Molecular BioSystems
https://www.readbyqxmd.com/read/26881018/dietary-phenolic-compounds-interfere-with-the-fate-of-hydrogen-peroxide-in-human-adipose-tissue-but-do-not-directly-inhibit-primary-amine-oxidase-activity
#20
Christian Carpéné, Mounia Hasnaoui, Balázs Balogh, Peter Matyus, Alfredo Fernández-Quintela, Víctor Rodríguez, Josep Mercader, Maria P Portillo
Resveratrol has been reported to inhibit monoamine oxidases (MAO). Many substrates or inhibitors of neuronal MAO interact also with other amine oxidases (AO) in peripheral organs, such as semicarbazide-sensitive AO (SSAO), known as primary amine oxidase, absent in neurones, but abundant in adipocytes. We asked whether phenolic compounds (resveratrol, pterostilbene, quercetin, and caffeic acid) behave as MAO and SSAO inhibitors. AO activity was determined in human adipose tissue. Computational docking and glucose uptake assays were performed in 3D models of human AO proteins and in adipocytes, respectively...
2016: Oxidative Medicine and Cellular Longevity
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