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Anu Haaramo, Heikki Alapulli, Liisa Aine, Jetta Tuokkola, Ulla Saarnisto, Risto P Roine, Anne Pitkäranta, Kaija-Leena Kolho
BACKGROUND: Up to 50% of pediatric patients with Crohn's disease (CD) report oral manifestations, but less is known about their oral health when they become adults. GOALS: Our aim was to provide detailed descriptions of the presence of oral and otorhinolaryngological manifestations in patients with pediatric onset CD once they reached adulthood, to look for predisposing factors and to compare the findings to matched controls. STUDY: Adult patients diagnosed with CD in childhood at the Children's Hospital, University of Helsinki, Finland, after 2000 were invited for a follow-up appointment in 2016 and 24 were examined by a dentist and otorhinolaryngologist...
June 16, 2018: Journal of Clinical Gastroenterology
Wael El-Matary, Thomas D Walters, Hien Q Huynh, Jennifer deBruyn, David R Mack, Kevan Jacobson, Mary E Sherlock, Peter Church, Eytan Wine, Matthew W Carroll, Eric I Benchimol, Sally Lawrence, Anne M Griffiths
Background: There is some evidence in adults that higher serum infliximab (IFX) levels are needed to adequately treat fistulizing perianal Crohn's disease (CD). However, data in children are lacking. We aimed to determine postinduction serum trough IFX levels that are associated with healing of fistulizing perianal CD (PCD) at week 24. Methods: In a multicenter inception cohort study, consecutive children younger than age 17 years with fistulizing perianal CD treated with IFX between April 2014 and June 2017 who had serum trough IFX titers measured before the fourth infusion were included...
June 15, 2018: Inflammatory Bowel Diseases
Susan E Little, Anne W Barrett, Yoko Nagamori, Brian H Herrin, Dorothy Normile, Kathleen Heaney, Rob Armstrong
Ticks are an important but under recognized parasitic threat to cats in many areas of the United States. To characterize the species and stages of ticks most commonly recovered from cats and determine the prevalence of disease agents in the ticks, we conducted a survey of ticks removed from cats at veterinary practices in 18 states from April 2016-June 2017. A total of 796 ticks were submitted from 332 cats from 41 different veterinary practices. A single tick was submitted from the majority of cats, with a mean infestation intensity of 2...
June 15, 2018: Veterinary Parasitology
M Fevzi Celayir, Kinyas Kartal, Mehmet Mihmanli
OBJECTIVES: Condyloma acuminata (CA) is mainly caused by human papillomavirus (HPV) types 6 and 11. Clinicians use many different methods to treat analcondyloma acuminate ( CA). In this study, we aimed to compare electrocautery ablation (ECA) and argon plasma coagulation (APC) techniques in terms of postoperative bleeding, pain, scar development, loss of sexual sensation, and recurrence rates. METHODS: A retrospective analysis of collected data was performed for 49consecutive patients with CA, who underwent surgery between July 2011 and July 2014...
June 14, 2018: Annali Italiani di Chirurgia
Michael Ryan, Hamad Alabdulrazzaq, Jennifer Toyohara
Perianal basal cell carcinoma (BCC) is a rare lesion that accounts for less than 0.08% of all BCCs. It is challenging to diagnose, as it can be overlooked or mistaken for an inflammatory dermatosis. When discovered early and treated properly, BCC is associated with low mortality and a good prognosis. Thorough total-body skin examinations and biopsy of suspected lesions found in the perianal region is recommended. We present a case of a superficial nodular perianal BCC that was discovered following a routine total-body skin examination and was treated with Mohs micrographic surgery (MMS)...
May 2018: Cutis; Cutaneous Medicine for the Practitioner
Paweł W Petryszyn, Leszek Paradowski
BACKGROUND: Crohn's disease (CD) and ulcerative colitis (UC) typically clinically manifest with symptoms like chronic diarrhea, cramps, abdominal pain, and rectal bleeding. However, symptoms of abnormal anorectal function seem to be of equal importance, regardless of the presence or absence of perianal disease. OBJECTIVES: The aim of this study was to assess stool patterns and the prevalence of symptoms of disordered anorectal function, particularly urgency and fecal incontinence, and their severity in patients with inflammatory bowel diseases (IBDs)...
June 12, 2018: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
X R Peng, Y Lu, M H Zhang, L T Li, X B Xie, J Y Gong, J S Wang
Objective: To explore the relationship between genotype and phenotype of ABCB11 deficiency. Methods: Clinical data of two siblings with ABCB11 deficiency were retrospectively analyzed. Related literature from PubMed, CNKI and Wangfang databases was reviewed to date (up to August 2017) with 'ABCB11 gene' or 'bile salt export pump', 'cholestasis' and 'child' as key words. Results: The patients were siblings. Both of them presented as jaundice, pruritus and hepatosplenomegaly since 3 days after birth. Significant laboratory findings on admission of the older sister included high total bilirubin, 170 µmol/L;conjugated bilirubin, 115...
June 2, 2018: Zhonghua Er Ke za Zhi. Chinese Journal of Pediatrics
Sevgen Tanır Basaranoglu, Yasemin Ozsurekci, Ali Bulent Cengiz, Eda Karadag Oncel, Kubrac Aykac, Ates Kara, Mehmet Ceyhan
INTRODUCTION: There are limited data on the aetiology and management of perianal abscesses (PAs). The aim of this retrospective study was to define the characteristics of children with PAs; describe our experience with PA from the perspective of paediatric infectious medicine and determine the factors that influence clinical outcomes. METHODS: We performed a retrospective review of cases of PA in children with no underlying disease managed in a tertiary referral hospital between January 2005 and July 2015...
June 4, 2018: Anales de Pediatría: Publicación Oficial de la Asociación Española de Pediatría (A.E.P.)
Bharati Kochar, Edward L Barnes, Hans H Herfarth, Christopher F Martin, Ashwin N Ananthakrishnan, Dermot McGovern, Millie Long, Robert S Sandler
Background: Inflammatory bowel disease (IBD) is increasing in Asians. We sought tobetter understand differences in IBD between Asians and whites in the United States (U.S.). Methods: We used data from the Sinai-Helmsley Alliance for Research Excellence cohort to assess disease characteristics for U.S.-born Asians, Asian immigrants and whites. We used bivariate analyses to describe clinical characteristics by race. We used logistic regression to determine baseline odds of immunosuppression and binomial regression to estimate risk ratios for worsening disease at follow-up...
March 2018: Inflammatory Intestinal Diseases
Wesley E Barry, Grace E Asuelime, Shengmei Zhou, Jeffrey Hammoudeh, Henri R Ford, Eugene S Kim
Perianal abscess and fistula-in-ano are well-described in the pediatric population. They are most common in infants less than 1 year of age and often resolve with oral antibiotics; occasionally they require drainage or fistulotomy. The etiology is commonly associated with cryptoglandular obstruction and subsequent infection, however alternative diagnoses should be considered in cases of recurrent abscesses and fistulae that are refractory to standard treatments. In this report, we present the case of an 8-year-old boy with a complex, recurrent fistula-in-ano that resulted from a rare congenital perirectal dermoid cyst...
2018: Frontiers in Pediatrics
Xiaohui Wu, Huanjun Huang, Hongyan Hou, Guanxin Shen, Jing Yu, Yu Zhou, Munyemana Jean Bosco, Lie Mao, Feng Wang, Ziyong Sun
Background: The differentiation between intestinal tuberculosis (ITB) and Crohn's disease (CD) is a challenge. The aim of this study was to investigate a predictive model for differential diagnosis between ITB and CD. Methods: A total of 268 patients who were suspected of having ITB or CD were prospectively recruited between January 2013 and September 2016. The clinical, laboratory, radiological, endoscopic, and histological features were investigated and subjected to univariate and multivariate analyses...
May 30, 2018: Inflammatory Bowel Diseases
Shaofang Wu, Wu Wang, Huan Chen, Wen Xiong, Xin Song, Xinmin Yu
RATIONALE: Ulcerative skin tuberculosis (TB) is a rare form of extrapulmonary TB. CASE REPORT: We present a case of a 65-year-old patient with perianal ulcer, which had been present for 1 year. Anamnesis revealed he had been persistently coughing for the same period of time. Histological examination of perianal skin showed necrotizing granulomatous lesions, acid-fast staining in sputum samples was ++++, TB antibody in the blood was positive, TB DNA test was positive, and chest scan that showed secondary pulmonary TB accompanied by possible pulmonary cavity formation in the 2 upper lungs...
June 2018: Medicine (Baltimore)
V Alegría-Landa, M Jo-Velasco, L Requena
A young woman presented with a perianal nodular lesion, which was found to have histopathological findings of hidradenoma papilliferum. The anal skin is an uncommon location for this neoplasm.
May 30, 2018: Clinical and Experimental Dermatology
Astrid-Helene Ravn Jørgensen, Yiqiu Yao, Simon Francis Thomsen
Hidradenitis suppurativa (HS) is a chronic inflammatory skin disorder involving primarily the intertriginous skin of the axillary, inguinal, genital, and perianal areas of the body. It is characterized by recurrent inflamed nodules and abscesses, resulting in fistulae, fibrosis, and scarring. We present a case of HS refractory to local and systemic antibiotic therapy as well as anti-TNF and anti-IL12/23 that was successfully treated with secukinumab (anti-IL17A).
2018: Case Reports in Dermatological Medicine
Juan José Cerezo-Manchado, Begoña Navarro-Almenzar, Ginés Elvira Ruiz, Faustino García-Candel, Pedro Flores Blanco, Cesar Caro-Martínez, Sergio Manzano-Fernández, Natalia García-Iniesta, Javier Sánchez-García, Valentín Cabañas-Perianes, José María Moraleda Jiménez
AIM: To evaluate the clinical profile and effectiveness/safety of patients taking rivaroxaban in clinical practice. METHODS: Retrospective study that included patients with nonvalvular atrial fibrillation treated with rivaroxaban for the prevention of stroke between January 2012 and December 2016 in a tertiary hospital in Spain. RESULTS: A total of 142 patients (median age 78 years, 40.1% men, 32.4% creatinine clearance <50 ml/min; 96...
May 2018: Future Cardiology
Francesca Prignano, Veronica Rogai, Elisabetta Cavallucci, Alessandro Bitossi, Volker Hammen, Fabrizio Cantini
PURPOSE OF REVIEW: Understanding prevalence of diseases within specific regions of a country is important for optimal allocation of healthcare resources/funds. We performed a systematic review to obtain a clearer picture of the epidemiology of psoriasis and psoriatic arthritis across and within specific regions of Italy. RECENT FINDINGS: Prevalence of psoriasis in specific regions showed more variability (0.8-4.5%) than that in the total population (1.8-3.1%). Prevalence of psoriatic arthritis in the general population was reported for only two regions, Chiavari (0...
May 30, 2018: Current Rheumatology Reports
Patrick Téoule, Steffen Seyfried, Andreas Joos, Dieter Bussen, Alexander Herold
PURPOSE: Proximal intersphincteric fistulas with proximal extension causing supralevatoric, retrorectal abscesses are a rare disease. There is only very limited experience, with small groups, and the limited published literature confirms the complexity of diagnostics and treatment. The aim of this study was to evaluate transrectal internal abscess drainage as planned definitive treatment. METHODS: We retrospectively studied medical records of all patients with the diagnosis of retrorectal abscesses that underwent transrectal internal abscess drainage in the Department of Colo-proctology of the University Medical Centre Mannheim (2003-2012)...
May 29, 2018: International Journal of Colorectal Disease
G Watermeyer, S Thomson
BACKGROUND: Overlapping clinical, endoscopic, radiographic and histological features, coupled with poor microbiological yield, make differentiating Crohn's disease (CD) from intestinal tuberculosis (ITB) challenging. Granulomas are present in both diseases; in CD they predict the need for immunosuppressive therapy that requires ITB to be excluded before initiation. OBJECTIVES: To compare granuloma-positive CD and ITB, to identify factors that may aid in diagnosis...
April 25, 2018: South African Medical Journal, Suid-Afrikaanse Tydskrif Vir Geneeskunde
Sanjog Bastola, Alexandra Halalau, Ojbindra Kc, Anju Adhikari
Buschke-Löwenstein tumor of anorectal and perianal area is a rare but highly aggressive tumor, frequently associated with human papillomavirus (HPV) types 6 and 11. It often grows over years in immunocompetent patients and can be highly destructive to local tissue. We present a case of a 61-year-old male with HIV infection who presented with worsening pain and swelling in the anorectal area for one-year duration. Exam revealed a 15 × 10 cm mass in the anorectal area with multiple sinuses and fistulas...
2018: Case Reports in Infectious Diseases
Samuel O Adegbola, Kapil Sahnan, Philip J Tozer, Raimund Strouhal, Ailsa L Hart, Phillip Fc Lung, Robin Ks Phillips, Omar Faiz, Janindra Warusavitarne
Methods: Consecutive patients with complex Crohn's fistula undergoing a VAAFT for symptomatic Crohn's anal fistula were included. They were identified from a prospectively maintained database, which was interrogated from June 2015-November 2017. Patients underwent diagnostic fistuloscopy and fulguration of tracts/secondary extensions. Setons were sited/replaced after the procedure to maintain postoperative drainage. Primary endpoint was completion of the "Measure your medical outcome profile" (MYMOP2) quality of life (QoL) questionnaire at 6 weeks postoperatively...
May 25, 2018: Journal of Crohn's & Colitis
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