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https://www.readbyqxmd.com/read/29243105/comparative-effectiveness-of-infliximab-versus-adalimumab-in-patients-with-biologic-na%C3%A3-ve-crohn-s-disease
#1
Amine Benmassaoud, Talal Al-Taweel, Mark Solomon Sasson, Dasha Moza, Matthew Strohl, Uri Kopylov, Laurence Paradis-Surprenant, Mohanad Almaimani, Alain Bitton, Waqqas Afif, Peter L Lakatos, Talat Bessissow
BACKGROUND: Direct head-to-head studies comparing the long-term outcomes of infliximab (IFX) to adalimumab (ADA) in Crohn's disease (CD) are sparse. AIMS: We compared the short-term and long-term efficacy and safety of IFX and ADA in CD. METHODS: We performed a single-center retrospective study including biologic-naïve adult patients with CD who were started on IFX or ADA at the McGill University Health Center. The primary end points were clinical response and remission at 12 months...
December 14, 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/29240869/recalcitrant-diffuse-cutaneous-sarcoidosis-with-perianal-involvement-responding-to-adalimumab
#2
George F Cohen, Christopher M Wolfe
<p>Recalcitrant cutaneous sarcoidosis with perianal involvement is rare. To our knowledge we present the first documented case of cutaneous sarcoidosis with perianal involvement successfully treated with adalimumab.</p> <p><em>J Drugs Dermatol. 2017;16(12):1305-1306.</em></p>.
December 1, 2017: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/29237100/perianal-tuberculosis-in-an-immunocompetent-patient
#3
Gabriela Mosena, Andréia Della Giustina Pires, Jessica Matos D'Almeida Santos, Joel Schwartz, Josué Victorino
Tuberculosis (TB) is a major public health problem worldwide, considered to be the main cause of death from infectious diseases, ranking alongside HIV infection. Skin involvement occurs in 1.5% of the cases, and perianal involvement is extremely rare and tends to occur among immunocompromised patients. Due to its heterogeneous clinical presentation, the diagnosis of cutaneous TB is challenging, requiring a high level of suspicion. This article is protected by copyright. All rights reserved.
December 13, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29232767/a-comparative-immunohistochemical-study-of-anal-canal-epithelium-in-humans-and-swine-focusing-on-the-anal-transitional-zone-epithelium-and-the-anal-glands
#4
Futoshi Muranaka, Tomoyuki Nakajima, Mai Iwaya, Keiko Ishii, Kayoko Higuchi, Naoko Ogiwara, Shinichi Miyagawa, Hiroyoshi Ota
To better understand the cellular origins and differentiation of anal canal epithelial neoplasms, the immunohistochemical profiles of the anal canal epithelium in humans and swine were evaluated. Formalin-fixed tissue sections were immunostained for mucin (MUC: MUC2, MUC5AC, MUC5B), desmoglein 3 (DGS3), p63, CDX2, SOX2, and α-smooth muscle actin (α-SMA). The anal transitional zone (ATZ) epithelium covered the anal sinus and consisted of a stratified epithelium with mucous cells interspersed within the surface lining...
December 12, 2017: Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology
https://www.readbyqxmd.com/read/29232211/improving-the-understanding-of-perianal-crohn-fistula-through-3d-modeling
#5
Kapil Sahnan, Samuel O Adegbola, Phillip J Tozer, Arun Gupta, Rachel Baldwin-Cleland, Nuha Yassin, Janindra Warusavitarne, Omar D Faiz, Ailsa L Hart, Robin K S Phillips, Phillip F C Lung
No abstract text is available yet for this article.
December 11, 2017: Annals of Surgery
https://www.readbyqxmd.com/read/29231502/-clinical-observation-of-chronic-perianal-eczema-treated-with-auricular-point-sticking-therapy-and-western-medication
#6
Yong Wen, Jun Li, Qing Long, Chuan Wan, Xiaolin Lan, Ye Chen
OBJECTIVE: To observe the differences in the therapeutic effects on chronic perianal eczema between auricular point sticking therapy and auricular sticking pseudo-press therapy on the basis of the treatment with western medication. METHODS: Ninety patients were randomized into an auricular therapy group and an auricular pseudo-press therapy group (pseudo group), 45 cases in each one. The western medication was used in both of the groups. In the auricular therapy group, the auricular sticking method with semen vaccariae was added at Fengxi (SF1,zi), Shenshangxian (TG2p), Duipingjian (AT1,2,4i), Fei (CO14), Pi (CO13), Gangmen (HX5)...
June 12, 2017: Zhongguo Zhen Jiu, Chinese Acupuncture & Moxibustion
https://www.readbyqxmd.com/read/29216685/patient-compliance-with-surveillance-colonoscopy-patient-factors-and-the-use-of-a-graded-recall-system
#7
Chahaya Gauci, Rebecca Lendzion, Kim-Chi Phan-Thien, Denis King, Dayashan S Perera
BACKGROUND: Surveillance colonoscopy allows for the early detection and improved treatment outcomes in colorectal neoplasms but compliance rates and factors require further investigation. METHODS: This is a retrospective cohort study examining 816 patients recalled for surveillance colonoscopy at an Australian colorectal practice over a 6-month period. Primary outcome was compliance with colonoscopy within 12 months of recall. The secondary outcome of this study was to identify factors affecting compliance including patient factors and the practices' graded recall system...
December 7, 2017: ANZ Journal of Surgery
https://www.readbyqxmd.com/read/29215479/major-abdominal-and-perianal-surgery-in-crohn-s-disease-long-term-follow-up-of-australian-patients-with-crohn-s-disease
#8
James W T Toh, Nelson Wang, Christopher J Young, Matthew J F X Rickard, Anil Keshava, Peter Stewart, Viraj Kariyawasam, Rupert Leong
BACKGROUND: Most patients with Crohn's disease still require surgery despite significant advances in medical therapy, surveillance, and management strategies. OBJECTIVE: The purpose of this study was to assess surgical strategies and outcomes in Crohn's disease, including surgical recurrence and emergency surgery. DESIGN: This was a multicenter, retrospective review of a prospectively collected database. SETTINGS: A specialist-referred cohort of patients with Crohn's disease between 1970 and 2009 was studied...
January 2018: Diseases of the Colon and Rectum
https://www.readbyqxmd.com/read/29215330/quantifying-hospital-acquired-carriage-of-extended-spectrum-beta-lactamase-producing-enterobacteriaceae-among-patients-in-dutch-hospitals
#9
Marjolein F Q Kluytmans-van den Bergh, Suzan P van Mens, Manon R Haverkate, Martin C J Bootsma, Jan A J W Kluytmans, Marc J M Bonten
BACKGROUND Extended-spectrum β-lactamase-producing Enterobacteriaceae (ESBL-E) are emerging worldwide. Contact precautions are recommended for known ESBL-E carriers to control the spread of ESBL-E within hospitals. OBJECTIVE This study quantified the acquisition of ESBL-E rectal carriage among patients in Dutch hospitals, given the application of contact precautions. METHODS Data were used from 2 cluster-randomized studies on isolation strategies for ESBL-E: (1) the SoM study, performed in 14 Dutch hospitals from 2011 through 2014 and (2) the R-GNOSIS study, for which data were limited to those collected in a Dutch hospital in 2014...
December 7, 2017: Infection Control and Hospital Epidemiology
https://www.readbyqxmd.com/read/29211872/misplacement-of-stent-into-epidural-venous-plexus-with-resultant-cauda-equina-syndrome-and-open-surgical-treatment-a-case-report
#10
Benjamin B Whiting, Celene B Mulholland, Lorin Daniels, U Kumar Kakarla, Nicholas Theodore, Laura A Snyder
BACKGROUND AND IMPORTANCE: Endovascular therapy has proven to be a safe, minimally invasive treatment for multiple etiologies, but proper precautions must be taken to avoid complications. When complications occur, they should be promptly identified and corrected when possible. This case report describes endovascular stents misplaced into the epidural spinous venous plexus rather than the iliofemoral arteries, causing cauda equina syndrome, as well as the spinal procedure performed to treat the resulting spinal canal compression...
December 2, 2017: Operative Neurosurgery (Hagerstown, Md.)
https://www.readbyqxmd.com/read/29209921/fourteen-year-anti-tnf-therapy-in-crohn-s-disease-patients-clinical-characteristics-and-predictive-factors
#11
Aisaku Osamura, Yasuo Suzuki
BACKGROUND: Crohn's disease (CD) is an intractable disease that requires long-term treatment. Tumor necrosis factor (TNF) inhibitors have strong efficacy and are widely used for CD treatment. However, a loss of response is one of the issues in long-term TNF therapy. To identify the factors affecting the efficacy of long-term CD treatment with TNF inhibitors, we conducted a retrospective study of treatment outcomes and clinical factors using clinical data over a 14-year period. METHODS: Clinical characteristics and factors for surgery, hospitalization, and TNF inhibitor treatment discontinuation were examined in 219 biologic-naïve patients who were treated with TNF inhibitors at our hospital before October 2014...
December 5, 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/29203997/perianal-paget-s-disease-a-case-report-and-a-review-of-current-diagnosis-and-management
#12
Chintamani Godbole, Jyoti Mehta, Bijoy Methil, Reshma Palep, Prajesh Bhuta
Paget's disease is an intraepithelial adenocarcinoma arising from the apocrine gland component of the skin. Paget's disease is most common in the breast but extra mammary disease is also seen. Perianal Paget's disease is a rare form of extramammary disease with few cases reported in literature. It can be primary-arising from the skin or secondary-cutaneous metastases of anorectal or genitourinary malignancy. We hereby wish to report a case of perianal Paget's disease that presented as an eczematous lesion and was diagnosed incidentally on biopsy...
December 2017: Indian Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29202553/extramammary-paget-s-disease-associated-with-genital-wart-and-lichen-sclerosus
#13
Rana Rafiei, Hojat Eftekhari, Siamak Granmayeh, Nahid Nickhah, Behnam Rafiee
Extramammary Paget's disease is an uncommon intraepithelial adenocarcinoma in genital and perianal regions. Genital wart is the most common sexually transmitted disease caused by human papilloma viruses and vulval lichen sclerosus is chronic pruritic dermatitis in genital area which could be able to change to invasive squamous cell carcinoma. We report a patient who had simultaneous lichen sclerosus, genital wart and extramammary Paget's disease of the vulva. We could not find any significant association between them in literature...
September 2017: Acta Medica Iranica
https://www.readbyqxmd.com/read/29199142/high-risk-of-anal-and-rectal-cancer-in-patients-with-anal-and-or-perianal-crohn-s-disease
#14
Laurent Beaugerie, Fabrice Carrat, Stéphane Nahon, Jean-David Zeitoun, Jean-Marc Sabate, Laurent Peyrin-Biroulet, Jean-Frédéric Colombel, Matthieu Allez, Jean-François Fléjou, Julien Kirchgesner, Magali Svrcek
BACKGROUND AND AIMS: Little is known about the magnitude of the risk of anal and rectal cancer in patients with anal and/or perineal Crohn's disease. We aimed to assess the risk of anal and rectal cancer in patients with Crohn's perianal disease followed in the Cancers Et Surrisque Associé aux Maladies inflammatoires intestinales En France (CESAME) cohort. METHODS: We collected data from 19,486 patients with Inflammatory Bowel Disease (IBD) enrolled in the observational CESAME study in France, from May 2004 through June 2005; 14...
November 30, 2017: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29191530/acute-bilateral-isolated-foot-drop-changing-the-paradigm-in-management-of-degenerative-spine-surgery-with-percutaneous-endoscopy
#15
Nitin Adsul, Hyeun Sung Kim, Sung Ho Choi, Jee-Soo Jang, Il-Tae Jang, Seong-Hoon Oh
BACKGROUND: Acute bilateral isolated foot drop due to Lumbar disc prolapse with canal stenosis is very rare with only three cases reported in literature. Our patient was managed using the percutaneous full endoscopic technique. This is mainly to highlight the ease of access and patient outcome with pre and postoperative images to support our minimally invasive treatment for this rare condition. CASE DESCRIPTION: A 46-year-old male presented with sudden onset severe back pain with bilateral foot drop...
November 27, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/29191059/optimization-of-biologic-therapy-in-crohn-s-disease
#16
Mohammed Razvi, Mark Lazarev
Crohn's disease (CD) is a manifestation of inflammatory bowel disease (IBD), which can result in significant morbidity. Biologic therapy with anti-TNF medication has been effective in treating inflammation and reducing complications in CD. It is important for clinicians to have better knowledge of the various biologic therapies including mechanisms of action and optimization strategies. Areas covered: The review describes optimization of biologic therapy in CD including different mechanisms of loss of response, therapeutic drug monitoring in CD, clinical implications and management strategies which utilize drug monitoring, and areas of future development and research in optimization of biologic therapy...
November 30, 2017: Expert Opinion on Biological Therapy
https://www.readbyqxmd.com/read/29182022/persistent-perianal-rash-in-a-young-boy
#17
Megan S Evans, Paul B Googe, Dean S Morrell
No abstract text is available yet for this article.
November 1, 2017: Clinical Pediatrics
https://www.readbyqxmd.com/read/29177796/molecular-and-cellular-mechanisms-involved-in-mesenchymal-stem-cell-based-therapy-of-inflammatory-bowel-diseases
#18
REVIEW
Bojana Simovic Markovic, Tatjana Kanjevac, C Randall Harrell, Marina Gazdic, Crissy Fellabaum, Nebojsa Arsenijevic, Vladislav Volarevic
Mesenchymal stem cells (MSCs) are promising resource for the therapy of inflammatory bowel diseases (IBDs) on the grounds of their differentiation capabilities and immuno-modulatory characteristics. Results of clinical studies indicate that local application of MSCs is a secure and beneficial approach for the treatment of perianal fistulas while systemic application of MSCs leads to the attenuation or aggravation of IBDs. Herein, we emphasized molecular mechanisms and approaches that should improve efficacy of MSC-based therapy of IBDs...
November 25, 2017: Stem Cell Reviews
https://www.readbyqxmd.com/read/29168104/safe-use-of-infliximab-for-the-treatment-of-severe-perianal-crohn-s-disease-after-diagnosis-and-treatment-of-lymphoma
#19
Carlos Bernardes, Pedro Russo, Diana Carvalho, Joana Saiote, Jaime Ramos
Inflammatory bowel disease is associated with an increased likelihood of developing lymphoma. However, it is still controversial if this risk may be attributed to the disease itself or rather represents an effect of immunosuppressive treatment. Although tumor necrosis factor alpha (TNFα) is a key cytokine for cancer immunosurveillance, the potential relationship between anti-TNFα agents and the pathogenesis of lymphoproliferative disorders remains unclear. Here, we describe the case of a patient with severe perianal Crohn's disease, treated with infliximab monotherapy, whose unusual presentation with acute groin pain required surgical intervention and led to the diagnosis of diffuse large B-cell lymphoma...
November 22, 2017: Clinical Journal of Gastroenterology
https://www.readbyqxmd.com/read/29166675/perianal-dermatitis-its-incidence-and-patterns-of-topical-therapies-in-a-level-iv-neonatal-intensive-care-unit
#20
Anuj Malik, Emily Witsberger, Lesley Cottrell, Autumn Kiefer, Panitan Yossuck
Objective To define the incidence of perianal dermatitis (PD) and determine the usage pattern and cost efficacy of diaper products among neonates admitted to a level IV neonatal intensive care unit (NICU) including those with a diagnosis of neonatal abstinence syndrome (NAS). Methods A retrospective cohort study to evaluate neonates with PD based on number of orders for Aquaphor, Bagbalm, Desitin, Flanders, or Nystatin. Various demographic and clinical parameters were recorded. Usage patterns of these five products were analyzed, and their costs estimated...
November 22, 2017: American Journal of Perinatology
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