Hiromitsu Asashima, Dongjoo Kim, Kaicheng Wang, Nikhil Lele, Nicholas C Buitrago-Pocasangre, Rachel Lutz, Isabella Cruz, Khadir Raddassi, William E Ruff, Michael K Racke, JoDell E Wilson, Tara S Givens, Alba Grifoni, Daniela Weiskopf, Alessandro Sette, Steven H Kleinstein, Ruth R Montgomery, Albert C Shaw, Fangyong Li, Rong Fan, David A Hafler, Mary M Tomayko, Erin E Longbrake
BACKGROUNDWhile B cell depletion is associated with attenuated antibody responses to SARS-CoV-2 mRNA vaccination, responses vary among individuals. Thus, elucidating the factors that affect immune responses after repeated vaccination is an important clinical need.METHODSWe evaluated the quality and magnitude of the T cell, B cell, antibody, and cytokine responses to a third dose of BNT162b2 or mRNA-1273 mRNA vaccine in patients with B cell depletion.RESULTSIn contrast with control individuals (n = 10), most patients on anti-CD20 therapy (n = 48) did not demonstrate an increase in spike-specific B cells or antibodies after a third dose of vaccine...
August 22, 2023: JCI Insight