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https://www.readbyqxmd.com/read/28432120/two-glycosaminoglycan-binding-domains-of-the-mouse-cytomegalovirus-encoded-chemokine-mck-2-are-critical-for-oligomerization-of-the-full-length-protein
#1
Sergio M Pontejo, Philip M Murphy
Chemokines are essential for antimicrobial host defenses and tissue repair. Herpesviruses and poxviruses also encode chemokines, copied from their hosts and repurposed for multiple functions, including immune evasion. The CC chemokine MCK-2 encoded by mouse cytomegalovirus (MCMV) has an atypical structure consisting of a classic chemokine domain N-terminal to a second unique domain, resulting from the splicing of MCMV ORFs m131 and m129. MCK-2 is essential for full MCMV infectivity in macrophages and for persistent infection in the salivary gland...
April 21, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28423973/neurological-involvement-of-igg4-related-disease-description-of-a-case-and-review-of-the-literature
#2
Marco Varrassi, Camilla Gianneramo, Francesco Arrigoni, Paolo Cerrone, Patrizia Sucapane, Carmine Marini, Alessandra Splendiani
IgG4-related disease is a recently discovered pathological entity, histologically characterised by fibrosis and IgG4-positive plasma cell infiltration. This condition may virtually involve every site of the organism, with a various range of clinical presentations. The most commonly affected organ is the pancreatic gland, but it can also involve the biliary tract, salivary and lacrimal glands, kidneys, orbital tissues, lymph nodes, lungs and many others. More recently, IgG4-related disease has been demonstrated to involve, in rare cases, also the central nervous system, with a pattern mainly characterised by hypertrophic pachymeningitis...
January 1, 2017: Neuroradiology Journal
https://www.readbyqxmd.com/read/28421710/synovial-sarcoma-metastatic-to-the-parotid-gland-a-possible-pitfall-in-salivary-gland-fine-needle-aspiration-cytology-report-of-a-case-with-immunocytochemical-and-fluorescence-in-situ-hybridization-findings
#3
Franco Fulciniti, Jessica Barizzi, Vittoria Martin, Vittorio Tarallo, Stefano Ermanni
We report one case of metastatic synovial sarcoma (SS) to the parotid gland in a 93-year-old male. The patient had undergone upper left pulmonary lobectomy with mediastinal lymphadenectomy for SS of the lung 5 years before. The cytopathologic presentation and the immunocytochemical findings on the FNA sample were suggestive of a spindle cell myoepithelioma, while a SYT rearrangement was identified by a FISH performed on a cytological smear of the lesion. The diagnosis was further confirmed also by positive immunocytochemical expression of TLE1 on a section from the obtained cell block...
April 19, 2017: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/28415674/primary-sj%C3%A3-gren-s-syndrome-with-diffuse-cystic-lung-changes-developed-systemic-lupus-erythematosus-a-case-report-and-literature-review
#4
Xiao Liu, Hao Li, Yunhong Yin, Dedong Ma, Yiqing Qu
Sjögren's syndrome (SS) is a chronic inflammatory autoimmune disease that can occur as a unique existence (primary Sjögren's syndrome) or merge with other systemic diseases like systemic lupus erythematosus (SLE), rheumatoid arthritis or systemic sclerosis (secondary Sjögren's syndrome). Data on the two diseases occurrence order are inadequate. Primary Sjögren's syndrome (pSS) may relatively uncommonly lead to diffuse cystic lung changes. We represent a female who was diagnosed pSS with diffuse cystic lung alterations developed SLE two years later...
March 8, 2017: Oncotarget
https://www.readbyqxmd.com/read/28409070/a-rare-case-of-a-benign-primary-pleomorphic-adenoma-of-the-lung
#5
Venkatkiran Kanchustambham, Swetha Saladi, Setu Patolia, Sara Mahmoud Assaf, David Stoeckel
Salivary gland tumors (SGT) constitute a small proportion of primary respiratory system neoplasms. Benign SGT comprises pleomorphic adenoma and is exceedingly rare in the lungs. We hereby present a rare case of a benign primary pleomorphic adenoma of the lung. The histological pattern of the tumor was indistinguishable from the head and neck SGT counterparts and showed biphasic morphology. Malignant features were not observed and a metastatic SGT was ruled out. Although little is known about the clinical progression of these rare tumors, surgical resection and interval surveillance remains the treatment of choice...
March 2, 2017: Curēus
https://www.readbyqxmd.com/read/28393980/-igg4-associated-nephritis-and-recurrent-hemoptysis-case-report
#6
Daniel Erlij, Ángela Rivera, Juan Carlos Maya, Carolina Cuellar, Gonzalo Correa, Susana Michalland, Gonzalo P Méndez
IgG4 disease is a multi-systemic condition involving pancreas, salivary glands and lymph nodes. Less frequently, it causes interstitial nephritis and involves the lungs. We report a 58 years old male with a four years history of hemoptysis and renal dysfunction characterized by hematuria and proteinuria, responsive to steroidal therapy. The renal biopsy established the diagnosis of IgG4 associated interstitial nephritis. Lung involvement was considered secondary to the same systemic disease.
January 2017: Revista Médica de Chile
https://www.readbyqxmd.com/read/28381457/a-novel-biomarker-associated-with-distress-in-humans-calcium-binding-protein-spermatid-specific-1-cabs1
#7
Thomas Ritz, David Rosenfield, Chris D St Laurent, Ana F Trueba, Chelsey A Werchan, Pia D Vogel, Richard J Auchus, Eduardo Reyes-Serratos, A Dean Befus
BACKGROUND: Calcium binding protein, spermatid specific 1 (CABS1) is expressed in human submandibular gland and has an anti-inflammatory motif similar to that in submandibular rat 1 (SMR1) in rats. Here we investigate CABS1 in human saliva and its association with psychological and physiological distress and inflammation in humans. METHOD: Volunteers participated across three studies: weekly baseline measures; a psychosocial speech and mental arithmetic stressor under evaluative threat; and during academic exam stress...
April 5, 2017: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
https://www.readbyqxmd.com/read/28349433/targeting-promoter-associated-noncoding-rna-in-vivo
#8
Gianluca Civenni
There are many classes of noncoding RNAs (ncRNAs), with wide-ranging functionalities (e.g., RNA editing, mediation of mRNA splicing, ribosomal function). MicroRNAs (miRNAs) and long ncRNAs (lncRNAs) are implicated in a wide variety of cellular processes, including the regulation of gene expression. Incorrect expression or mutation of lncRNAs has been reported to be associated with several disease conditions, such a malignant transformation in humans. Importantly, pivotal players in tumorigenesis and cancer progression, such as c-Myc, may be regulated by lncRNA at promoter level...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28341276/lung-metastasectomy-in-adenoid-cystic-cancer-is-it-worth-it
#9
Lara Girelli, Laura Locati, Carlotta Galeone, Paolo Scanagatta, Leonardo Duranti, Lisa Licitra, Ugo Pastorino
BACKGROUND AND PURPOSE: Adenoid cystic carcinoma (ACC) of salivary glands is characterized by long-term distant metastasis, most commonly in lungs. No agreement has been reached about the role of surgical treatment of pulmonary lesions. We evaluated the long-term results of lung metastasectomy for ACC in order to identify factors that should be taken into account in selecting patients eligible for surgery and treatment planning. PATIENTS AND METHODS: A retrospective study was conducted on 109 patients selected from our institutional experience and from the International Registry of Lung Metastases...
February 2017: Oral Oncology
https://www.readbyqxmd.com/read/28325631/new-concepts-of-personalized-therapy-in-salivary-gland-carcinomas
#10
REVIEW
Gunter Keller, Diana Steinmann, Alexander Quaas, Viktor Grünwald, Stefan Janssen, Kais Hussein
Salivary gland carcinomas are rare tumours and therapy strategies are less standardized than in lung, gastric or breast cancer. Therapy is based on surgery, but not all carcinomas are completely resectable, e.g. because carcinomas often show infiltration of nerves. For further therapy decision pathology is recommended, but evaluation of potential targets for personalized therapy is not part of the routine panel. Many salivary gland carcinomas can be resistant to radio- and/or chemotherapy, which limits therapeutic options...
March 18, 2017: Oral Oncology
https://www.readbyqxmd.com/read/28306727/biodistribution-and-pet-imaging-of-pharmacokinetics-of-manganese-in-mice-using-manganese-52
#11
A Lake Wooten, Tolulope A Aweda, Benjamin C Lewis, Rebecca B Gross, Suzanne E Lapi
Manganese is essential to life, and humans typically absorb sufficient quantities of this element from a normal healthy diet; however, chronic, elevated ingestion or inhalation of manganese can be neurotoxic, potentially leading to manganism. Although imaging of large amounts of accumulated Mn(II) is possible by MRI, quantitative measurement of the biodistribution of manganese, particularly at the trace level, can be challenging. In this study, we produced the positron-emitting radionuclide 52Mn (t1/2 = 5.6 d) by proton bombardment (Ep<15 MeV) of chromium metal, followed by solid-phase isolation by cation-exchange chromatography...
2017: PloS One
https://www.readbyqxmd.com/read/28288723/clinical-features-and-management-of-non-gastrointestinal-non-ocular-extranodal-mucosa-associated-lymphoid-tissue-enmalt-marginal-zone-lymphomas
#12
REVIEW
Estella Matutes, Carlos Montalban
Extranodal mucosa associated lymphoid tissue (ENMALT) marginal zone lymphomas may arise at any site of the body. The most frequent localizations other than gastrointestinal and eye are salivary gland, skin, lung and thyroid. These lymphomas usually arise in a setting of inflammation due to a persistent infection or autoimmune diseases such as Sjogren syndrome in salivary MALT lymphomas and Hashimoto's thryroiditis in thyroid lymphomas. They affect middle-aged patients with a female predominance when lymphoma arises in certain locations...
March 2017: Best Practice & Research. Clinical Haematology
https://www.readbyqxmd.com/read/28245826/host-pathogen-interplay-at-primary-infection-sites-in-pigs-challenged-with-actinobacillus-pleuropneumoniae
#13
Elena L Sassu, Janna Frömbling, J Catharina Duvigneau, Ingrid Miller, Andrea Müllebner, Ana M Gutiérrez, Tom Grunert, Martina Patzl, Armin Saalmüller, Alexandra von Altrock, Anne Menzel, Martin Ganter, Joachim Spergser, Marion Hewicker-Trautwein, Jutta Verspohl, Monika Ehling-Schulz, Isabel Hennig-Pauka
BACKGROUND: Actinobacillus (A.) pleuropneumoniae is the causative agent of porcine pleuropneumonia and causes significant losses in the pig industry worldwide. Early host immune response is crucial for further progression of the disease. A. pleuropneumoniae is either rapidly eliminated by the immune system or switches to a long-term persistent form. To gain insight into the host-pathogen interaction during the early stages of infection, pigs were inoculated intratracheally with A. pleuropneumoniae serotype 2 and humanely euthanized eight hours after infection...
February 28, 2017: BMC Veterinary Research
https://www.readbyqxmd.com/read/28243943/fluoride-alteration-of-3-h-glucose-uptake-in-wistar-rat-brain-and-peripheral-tissues
#14
Anna Rogalska, Katarzyna Kuter, Aleksandra Żelazko, Anna Głogowska-Gruszka, Elżbieta Świętochowska, Przemysław Nowak
The present study was designed to investigate the role of postnatal fluoride intake on [3H]glucose uptake and transport in rat brain and peripheral tissues. Sodium fluoride (NaF) in a concentration of 10 or 50 ppm was added to the drinking water of adult Wistar rats. The control group received distilled water. After 4 weeks, respective plasma fluoride levels were 0.0541 ± 0.0135 μg/ml (control), 0.0596 ± 0.0202 μg/ml (10 ppm), and 0.0823 ± 0.0199 μg/ml (50 ppm). Although plasma glucose levels were not altered in any group, the plasma insulin level in the fluoride (50 ppm) group was elevated (0...
April 2017: Neurotoxicity Research
https://www.readbyqxmd.com/read/28214199/primary-acinic-cell-carcinoma-of-the-lung-with-psammoma-bodies-a-case-report-and-review-of-literature
#15
Xiu-Peng Zhang, Gui-Yang Jiang, Qing-Fu Zhang, Hong-Tao Xu, Qing-Chang Li, En-Hua Wang
Salivary gland-type tumors are rare in the lung. Primary acinic cell carcinoma of the lung is extremely rare. Here, we report a case of primary acinic cell carcinoma of the lung with prominent psammoma bodies. A 31-year-old man came to our hospital with a tumor in the basal segment of the lower lobe of the right lung. The tumor tissue displayed solid, acinar, or microcystic structures at different regions. A large amount of psammoma bodies were scattered in more than half of the tumor. The majority of the tumor cells were round or polygonal in shape, with abundant acidophilic granular or vacuolated cytoplasm...
January 19, 2017: Pathology, Research and Practice
https://www.readbyqxmd.com/read/28210575/cytokeratin-immunoprofile-of-primary-and-metastatic-adenoid-cystic-carcinoma-of-salivary-glands-a-report-of-two-cases
#16
Cibele Pidorodeski Nagano, Cláudia Malheiros Coutinho-Camillo, Clovis Antônio Pinto, Fernando Augusto Soares, Filipa Santos, Isabel Fonseca, Silvia Vanessa Lourenço
Distant metastases from salivary gland tumors are considered infrequent: the incidence of distant metastases ranges from 24% to 61% according to different histotypes and to the site of the primary mass. The most common site of distant metastases due to salivary gland malignancies is the lung. From the pathology point of view, cytokeratins (CK) are important differentiation markers in salivary gland tumors, which are often used for the diagnostic process. Their employment also may be useful to identify and confirm the diagnosis of their distant metastases...
October 2016: Autopsy & case reports
https://www.readbyqxmd.com/read/28099576/bpi-fold-bpif-containing-plunc-protein-expression-in-human-fetal-major-and-minor-salivary-glands
#17
Daniel Berretta Moreira Alves, Lynne Bingle, Colin David Bingle, Silvia Vanessa Lourenço, Andréia Aparecida Silva, Débora Lima Pereira, Pablo Agustin Vargas
The aim of this study was to determine expression, not previously described, of PLUNC (palate, lung, and nasal epithelium clone) (BPI-fold containing) proteins in major and minor salivary glands from very early fetal tissue to the end of the second trimester and thus gain further insight into the function of these proteins. Early fetal heads, and major and minor salivary glands were collected retrospectively and glands were classified according to morphodifferentiation stage. Expression of BPI-fold containing proteins was localized through immunohistochemistry...
January 16, 2017: Brazilian Oral Research
https://www.readbyqxmd.com/read/28091932/current-concept-of-igg4-related-disease
#18
Kazuichi Okazaki, Hisanori Umehara
IgG4-related disease (IgG4-RD) is a fibroinflammatory disease of unknown etiology, which is characterized by a tendency to form tumefactive lesions, increased serum levels of IgG4, and massive infiltration of IgG4-positive plasma cells with storiform fibrosis and/or obliterative phlebitis. Patients with IgG4-RD have frequently multiorgan involvements such as the pancreas, biliary tree, salivary glands, periorbital tissues, kidneys, lungs, lymph nodes, and retroperitoneum. IgG4-RD mainly affects middle-aged to elderly men except for involvement in lachrymal and salivary glands, so-called Mikulicz's disease...
2017: Current Topics in Microbiology and Immunology
https://www.readbyqxmd.com/read/28061862/bulbar-conjunctival-metastasis-from-mucoepidermoid-carcinoma-of-parotid-a-case-report-and-review-of-literature
#19
Rajshri Yadav, Azhar J Battoo, Abdul W Mir, Altaf G Haji
BACKGROUND: Mucoepidermoid carcinoma of salivary glands usually metastasizes to the lungs, liver, bone, brain, and skin. We report a rare case of distant metastasis of high-grade mucoepidermoid carcinoma of the parotid to the ipsilateral bulbar conjunctiva of the eye. CASE PRESENTATION: Sixty-year-old male of Kashmiri origin presented to our tertiary care referral cancer institute with exophytic lesion of the left bulbar conjunctiva following his treatment for mucoepidermoid cancer of ipsilateral parotid gland, 9 months back...
January 7, 2017: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28049394/coexistence-of-amyloidosis-and-primary-sj%C3%A3-gren-s-syndrome-an-overview-amyloidosis-and-sj%C3%A3-gren-s-syndrome
#20
Gabriela Hernandez-Molina, David Faz-Muñoz, Miguel Astudillo-Angel, Alejandra Iturralde-Chávez, Edgardo Reyes
BACKGROUND: The association of primary Sjögren´s syndrome (SS) and amyloidosis has been recognized but scarcely assessed. OBJECTIVE: Herein we analyzed the literature regarding this association in order to describe a SS phenotype prone to both conditions. METHODS: PubMed and CINAHL databases were searched from inception until April 2016 for the key words: amyloidosis, amyloid, Sjögren's syndrome and their combinations. RESULTS: Most of the cases corresponded to localized amyloidosis mainly at skin and lung, whereas only three cases were systemic...
January 3, 2017: Current Rheumatology Reviews
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