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Salivary gland and stem cell

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https://www.readbyqxmd.com/read/29776537/comparative-study-on-metabolite-level-in-tissue-specific-human-mesenchymal-stem-cells-by-an-ultra-performance-liquid-chromatography-quadrupole-time-of-flight-mass-spectrometry
#1
Seul Ji Lee, TacGhee Yi, Soo Hyun Ahn, Dong Kyu Lim, Si-Na Kim, Hyun-Joo Lee, Yun-Kyoung Cho, Jae-Yol Lim, Jong-Hyuk Sung, Jeong-Ho Yun, Johan Lim, Sun U Song, Sung Won Kwon
Mesenchymal stem cells (MSCs) are a promising therapeutic option for cell-based therapy due to their immunomodulatory and regenerative properties. They can be isolated from various adult tissues, including bone marrow, fat, dental tissue, and glandular tissue. Although they share common characteristics, little is known about the biological differences between MSC populations derived from different tissues. In this study, we used MS to compare the endogenous metabolite level in the human MSCs originating from the bone marrow, adipose tissue, periodontal ligaments, and salivary glands...
September 18, 2018: Analytica Chimica Acta
https://www.readbyqxmd.com/read/29771921/mosquito-saliva-alone-has-profound-effects-on-the-human-immune-system
#2
Megan B Vogt, Anismrita Lahon, Ravi P Arya, Alexander R Kneubehl, Jennifer L Spencer Clinton, Silke Paust, Rebecca Rico-Hesse
Mosquito saliva is a very complex concoction of >100 proteins, many of which have unknown functions. The effects of mosquito saliva proteins injected into our skin during blood feeding have been studied mainly in mouse models of injection or biting, with many of these systems producing results that may not be relevant to human disease. Here, we describe the numerous effects that mosquito bites have on human immune cells in mice engrafted with human hematopoietic stem cells. We used flow cytometry and multiplex cytokine bead array assays, with detailed statistical analyses, to detect small but significant variations in immune cell functions after 4 mosquitoes fed on humanized mice footpads...
May 2018: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29736173/inhibitory-effects-of-ipsc-mscs-and-their-extracellular-vesicles-on-the-onset-of-sialadenitis-in-a-mouse-model-of-sj%C3%A3-gren-s-syndrome
#3
Bo Hai, Taeko Shigemoto-Kuroda, Qingguo Zhao, Ryang Hwa Lee, Fei Liu
No effective treatment for Sjögren's syndrome (SS), a chronic autoimmune disease affecting mainly salivary and lacrimal glands, is available now. Systemic infusion of allogeneic mesenchymal stem cells (MSCs) isolated from tissues such as bone marrow (BM) alleviated SS in mouse models and a small clinical trial, but further research and application of this MSC therapy were hindered by limited expandability, significant donor variations, and safety concerns of tissue-derived MSCs. To circumvent these issues, we derived MSCs from human iPSCs using an optimized protocol that can be easily scaled up to produce a huge amount of standardized MSCs...
2018: Stem Cells International
https://www.readbyqxmd.com/read/29679075/apkc%C3%AE-dependent-repression-of-yap-is-necessary-for-functional-restoration-of-irradiated-salivary-glands-with-igf-1
#4
Alejandro M Chibly, Wen Yu Wong, Maricela Pier, Hongqiang Cheng, Yongxin Mu, Ju Chen, Sourav Ghosh, Kirsten H Limesand
Xerostomia and salivary hypofunction often result as a consequence of radiation therapy for head and neck cancers, which are diagnosed in roughly 60,000 individuals every year in the U.S. Due to the lack of effective treatments for radiation-induced salivary hypofunction, stem cell-based therapies have been suggested to regenerate the irradiated salivary glands. Pharmacologically, restoration of salivary gland function has been accomplished in mice by administering IGF-1 shortly after radiation treatment, but it is not known if salivary stem and progenitor cells play a role...
April 20, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29678523/safety-and-efficacy-of-mesenchymal-stem-cells-for-radiation-induced-xerostomia-a-randomized-placebo-controlled-phase-1-2-trial-mesrix
#5
Christian Grønhøj, David H Jensen, Peter Vester-Glowinski, Siri Beier Jensen, Allan Bardow, Roberto S Oliveri, Lea Munthe Fog, Lena Specht, Carsten Thomsen, Sune Darkner, Michael Jensen, Vera Müller, Katalin Kiss, Tina Agander, Elo Andersen, Anne Fischer-Nielsen, Christian von Buchwald
BACKGROUND: Salivary gland hypofunction and xerostomia are major complications to head and neck radiotherapy. This trial assessed the safety and efficacy of adipose tissue-derived mesenchymal stem cell (ASC) therapy for radiation-induced xerostomia. PATIENT AND METHODS: This randomized, placebo-controlled phase 1/2 trial included 30 patients, randomized in a 1:1 ratio to receive ultrasound-guided transplantation of ASCs or placebo to the submandibular glands. Patients had previously received radiotherapy for a T1-2, N0-2A, human papillomavirus-positive, oropharyngeal squamous cell carcinoma...
March 6, 2018: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/29670709/comparative-study-of-the-osteogenic-potential-of-mesenchymal-stem-cells-derived-from-different-sources
#6
Iman M Aboushady, Zeinab A Salem, Dina Sabry, Abbas Mohamed
Background: Mesenchymal stem cells (MSCs) can regenerate missing tissues and treat diseases. Hence, the current work aimed to compare the proliferation rate and the osteogenic differentiation potential of bone marrow MSCs (BMSCs), gingival MSCs (GMSCs) and submandibular MSCs (SMSCs). Material and Methods: MSCs derived from bone marrow, gingiva and submandibular salivary gland were isolated and cultured from rats. The proliferation capacity was judged by MTT proliferation Assay...
January 2018: Journal of Clinical and Experimental Dentistry
https://www.readbyqxmd.com/read/29663717/salivary-gland-stem-cells-a-review-of-development-regeneration-and-cancer
#7
REVIEW
Elaine Emmerson, Sarah M Knox
Salivary glands are responsible for maintaining the health of the oral cavity and are routinely damaged by therapeutic radiation for head and neck cancer as well as by autoimmune diseases such as Sjögren's syndrome. Regenerative approaches based on the reactivation of endogenous stem cells or the transplant of exogenous stem cells hold substantial promise in restoring the structure and function of these organs to improve patient quality of life. However, these approaches have been hampered by a lack of knowledge on the identity of salivary stem cell populations and their regulators...
April 16, 2018: Genesis: the Journal of Genetics and Development
https://www.readbyqxmd.com/read/29620098/maintenance-of-the-spheroid-organization-and-properties-of-glandular-progenitor-cells-by-fabricated-chitosan-based-biomaterials
#8
Hao-Wei Lee, Ya-Chuan Hsiao, Tai-Horng Young, Tsung-Lin Yang
Dysfunctional salivary gland (SG) is an unsolved clinical challenge, which is presented as xerostomia. Cell therapy is a promising treatment for restoring SG function. Salispheres are spheroid cellular organizations derived from SG stem cells. Benefitting from these cellular organizations, SG stem cells can be expanded to regenerate SG. During in vitro culture, the spontaneous reorganization of salispheres may change the features of residing SG stem cells. Therefore, it is imperative to explore ways to maintain the spheroid structure of salispheres during cell expansion in vitro...
April 5, 2018: Biomaterials Science
https://www.readbyqxmd.com/read/29615296/reexamining-post-transplant-lymphoproliferative-disorders-newly-recognized-and-enigmatic-types
#9
REVIEW
Nadine Aguilera, Alejandro A Gru
Post-transplant lymphoproliferative disorders (PTLD) are a known risk for both solid organ transplant and stem cell transplant recipients. Overall transplant recipients have a six fold increase in risk for developing any kind of non-Hodgkin lymphoma and PTLDs occur in up to 10% of SOT recipients. Several new entities have been accepted or renamed in the 2018 update of the WHO classification of tumors of hematopoietic and lymphoid neoplasms, including florid follicular hyperplasia and extranodal marginal zone lymphomas of mucosa-associated lymphoid tissue (MALT-lymphoma) (excluding common locations such as stomach and salivary gland)...
March 3, 2018: Seminars in Diagnostic Pathology
https://www.readbyqxmd.com/read/29590144/administration-of-growth-factors-promotes-salisphere-formation-from-irradiated-parotid-salivary-glands
#10
Vicky T Nguyen, Peter Dawson, Qionghui Zhang, Zoey Harris, Kirsten H Limesand
Worldwide, 500,000 cases of head and neck cancer (HNC) are reported each year and the primary treatment for HNC is radiotherapy. Although the goal of radiotherapy is to target the tumor, secondary exposure occurs in surrounding normal tissues, such as the salivary glands. As a result, despite successful treatment of the cancer, patients are left with long-term side effects due to direct damage to the salivary glands. The effect is chronic and currently there is no treatment. Stem cells are an attractive therapeutic option for treatment of radiation-induced glandular dysfunction because of the potential to regenerate damaged cell populations and restore salivary gland function...
2018: PloS One
https://www.readbyqxmd.com/read/29569790/hypoxia-activated-adipose-mesenchymal-stem-cells-prevents-irradiation-induced-salivary-hypofunction-by-enhanced-paracrine-effect-through-fgf10
#11
Hyun-Soo Shin, Songyi Lee, Young-Mo Kim, Jae-Yol Lim
PURPOSE: To explore the effects and mechanisms of paracrine factors secreted from human adipose mesenchymal stem cells (hAdMSCs) that are activated by hypoxia on radioprotection against irradiation-induced salivary hypofunction in subjects undergoing radiotherapy for head and neck cancers. MATERIALS AND METHODS: An organotypic spheroid coculture model to mimic IR-induced salivary hypofunction was set up for in vitro experiments. Human parotid gland epithelial cells were organized to form three-dimensional acinus-like spheroids on growth factor reduced (GFR)-Matrigel...
March 23, 2018: Stem Cells
https://www.readbyqxmd.com/read/29566770/stem-cell-properties-of-human-clonal-salivary-gland-stem-cells-are-enhanced-by-three-dimensional-priming-culture-in-nanofibrous-microwells
#12
Hyun-Soo Shin, Songyi Lee, Hye Jin Hong, Young Chang Lim, Won-Gun Koh, Jae-Yol Lim
BACKGROUND: Three-dimensional (3D) cultures recapitulate the microenvironment of tissue-resident stem cells and enable them to modulate their properties. We determined whether salivary gland-resident stem cells (SGSCs) are primed by a 3D spheroid culture prior to treating irradiation-induced salivary hypofunction using in-vitro coculture and in-vivo transplant models. METHODS: 3D spheroid-derived SGSCs (SGSCs3D ) were obtained from 3D culture in microwells consisting of a nanofiber bottom and cell-repellent hydrogel walls, and were examined for salivary stem or epithelial gene/protein expression, differentiation potential, and paracrine secretory function compared with monolayer-cultured SGSCs (SGSCs2D ) in vitro and in vivo...
March 22, 2018: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/29555661/salivary-gland-cancer-patient-derived-xenografts-enable-characterization-of-cancer-stem-cells-and-new-gene-fusions-associated-with-tumor-progression
#13
Stephen Keysar, Justin Eagles, Bettina Miller, Brian C Jackson, Farshad N Chowdhury, Julie Reisinger, Tugs-Saikhan Chimed, Phuong N Le, J Jason Morton, Hilary Somerset, Marileila Varella-Garcia, Aik-Choon Tan, John I Song, Daniel W Bowles, Mary E Reyland, Antonio Jimeno
PURPOSE: Salivary gland cancers (SGC) frequently present with distant metastases many years after diagnosis, suggesting a cancer stem cell (CSC) subpopulation that initiates late recurrences; however current models are limited both in their availability and suitability to characterize these rare cells. EXPERIMENTAL DESIGN: Patient-derived xenografts (PDX) were generated by engrafting patient tissue onto nude mice from one acinic cell carcinoma (AciCC), four adenoid cystic carcinoma (ACC), and three mucoepidermoid carcinoma (MEC) cases, which were derived from successive relapses from the same MEC patient...
March 19, 2018: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/29536733/effect-of-cell-sex-on-uptake-of-nanoparticles-the-overlooked-factor-at-the-nanobio-interface
#14
Vahid Serpooshan, Sara Sheibani, Pooja Pushparaj, Michal Wojcik, Albert Y Jang, Michelle R Santoso, Joyce H Jang, Haina Huang, Reihaneh Safavi-Sohi, Niloofar Haghjoo, Hossein Nejadnik, Haniyeh Aghaverdi, Hojatollah Vali, Joseph Matthew Kinsella, John Presley, Ke Xu, Phillip Chung-Ming Yang, Morteza Mahmoudi
Cellular uptake of nanoparticles (NPs) depends on the nature of the nanobio system including the solid nanocomponents ( e. g., physicochemical properties of NPs), nanobio interfaces ( e. g., protein corona composition), and the cellular characteristics ( e. g., cell type). In this study, we document the role of sex in cellular uptake of NPs as an "overlooked" factor in nanobio interface investigations. We demonstrate that cell sex leads to differences in NP uptake between male and female human amniotic stem cells (hAMSCs), with greater uptake by female cells...
March 27, 2018: ACS Nano
https://www.readbyqxmd.com/read/29484115/transcriptomes-define-distinct-subgroups-of-salivary-gland-adenoid-cystic-carcinoma-with-different-driver-mutations-and-outcomes
#15
Candace A Frerich, Kathryn J Brayer, Brandon M Painter, Huining Kang, Yoshitsugu Mitani, Adel K El-Naggar, Scott A Ness
The relative rarity of salivary gland adenoid cystic carcinoma (ACC) and its slow growing yet aggressive nature has complicated the development of molecular markers for patient stratification. To analyze molecular differences linked to the protracted disease course of ACC and metastases that form 5 or more years after diagnosis, detailed RNA-sequencing (RNA-seq) analysis was performed on 68 ACC tumor samples, starting with archived, formalin-fixed paraffin-embedded (FFPE) samples up to 25 years old, so that clinical outcomes were available...
January 26, 2018: Oncotarget
https://www.readbyqxmd.com/read/29434684/intraglandular-transplantation-of-adipose-derived-stem-cells-combined-with-platelet-rich-fibrin-extract-for-the-treatment-of-irradiation-induced-salivary-gland-damage
#16
Zhifa Wang, Hongyan Xing, Hanqing Hu, Taiqiang Dai, Yan Wang, Zhijin Li, Ran An, Haiyan Xu, Yanpu Liu, Bin Liu
The aim of the present study was to determine the effect of adipose-derived mesenchymal stem cells (ADSCs) combined with heterologous platelet-rich fibrin extract (PRFe) on irradiation-induced salivary gland (SG) damage. ADSCs were isolated from C3H mice, whereas PRFe was obtained from New Zealand rabbits. Twelve weeks post irradiation, the ADSCs or PRFe or their combination were transplanted into the submandibular glands of C3H mice with irradiation-induced damage. The salivary flow rate (SFR) was determined and histopathological analysis was performed at 12 weeks post transplantation...
January 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29391537/targeting-histone-deacetylase-and-nf%C3%AE%C2%BAb-signaling-as-a-novel-therapy-for-mucoepidermoid-carcinomas
#17
Vivian P Wagner, Manoela D Martins, Marco A T Martins, Luciana O Almeida, Kristy A Warner, Jacques E Nör, Cristiane H Squarize, Rogerio M Castilho
Malignancies from the salivary glands are rare and represent 11% of all cancers from the oropharyngeal anatomical area. Mucoepidermoid Carcinomas (MEC) is the most common malignancy from the salivary glands. Low survival rates of high-grade Mucoepidermoid Carcinomas (MEC) are particularly associated with the presence of positive lymph nodes, extracapsular lymph node spread, and perineural invasion. Most recently, the presence of cancer stem cells (CSC), and the activation of the NFκB signaling pathway have been suggested as cues for an acquired resistance phenotype...
February 1, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29387612/expression-of-vascular-endothelial-cadherin-in-mucoepidermoid-carcinoma-role-in-cancer-development
#18
Soussan Irani, Arash Dehghan
Objectives: Mucoepidermoid carcinoma (MEC) accounts for 35% of all malignant salivary gland tumors. Previous investigations have shown that vasculogenic mimicry (VM) exists in many cancers which can be used as a prognostic factor of poor prognosis. Elevated expression level of vascular endothelial (VE)-cadherin has been implicated in cancer neovascularization, growth, and progression. The current study aimed to study the presence of VE-cadherin in VM channels and tumor cells in different grades of MEC...
November 2017: Journal of International Society of Preventive & Community Dentistry
https://www.readbyqxmd.com/read/29363541/vitamin-a-coupled-liposomes-containing-sirna-against-hsp47-ameliorate-skin-fibrosis-in-chronic-graft-versus-host-disease
#19
Tomohiro Yamakawa, Hiroyuki Ohigashi, Daigo Hashimoto, Eiko Hayase, Shuichiro Takahashi, Miyono Miyazaki, Kenjiro Minomi, Masahiro Onozawa, Yoshiro Niitsu, Takanori Teshima
Chronic graft-versus-host disease (GVHD) after allogeneic hematopoietic stem cell transplantation (SCT) is characterized by multiorgan fibrosis and profoundly affects the quality of life of transplant survivors. Heat shock protein 47 (HSP47), a collagen-specific molecular chaperone, plays a critical role in collagen synthesis in myofibroblasts. We explored the role of HSP47 in the fibrotic process of cutaneous chronic GVHD in mice. Immunohistochemical analysis showed massive fibrosis with elevated amounts of collagen deposits and accumulation of F4/80+ macrophages, as well as myofibroblasts expressing HSP47 and retinol-binding protein 1 in the skin after allogeneic SCT...
March 29, 2018: Blood
https://www.readbyqxmd.com/read/29335337/salivary-glands-regenerate-after-radiation-injury-through-sox2-mediated-secretory-cell-replacement
#20
Elaine Emmerson, Alison J May, Lionel Berthoin, Noel Cruz-Pacheco, Sara Nathan, Aaron J Mattingly, Jolie L Chang, William R Ryan, Aaron D Tward, Sarah M Knox
Salivary gland acinar cells are routinely destroyed during radiation treatment for head and neck cancer that results in a lifetime of hyposalivation and co-morbidities. A potential regenerative strategy for replacing injured tissue is the reactivation of endogenous stem cells by targeted therapeutics. However, the identity of these cells, whether they are capable of regenerating the tissue, and the mechanisms by which they are regulated are unknown. Using in vivo and ex vivo models, in combination with genetic lineage tracing and human tissue, we discover a SOX2+ stem cell population essential to acinar cell maintenance that is capable of replenishing acini after radiation...
January 15, 2018: EMBO Molecular Medicine
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