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Radiation and salivary gland

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https://www.readbyqxmd.com/read/29767566/external-beam-radiotherapy-for-the-treatment-of-feline-salivary-gland-carcinoma-six-new-cases-and-a-review-of-the-literature
#1
Laura Blackwood, Aaron Harper, James Elliott, Irina Gramer
Case series summary Salivary gland carcinoma is uncommon in cats. We report the outcome of radiation therapy in six cases (four salivary gland adenocarcinomas, one tubulopapillary adenocarcinoma, one carcinoma). Five were treated after surgical excision of the primary tumour, but four had gross disease (primary or metastatic) at the time of starting radiotherapy. Exact progression-free interval from the start of radiotherapy in the two cats where this was known was 120 and 144 days, respectively. One cat was signed off at 766 days with no evidence of recurrence...
May 1, 2018: Journal of Feline Medicine and Surgery
https://www.readbyqxmd.com/read/29765265/is-volumetric-modulated-arc-therapy-with-constant-dose-rate-a-valid-option-in-radiation-therapy-for-head-and-neck-cancer-patients
#2
Annamaria Didona, Valentina Lancellotta, Claudio Zucchetti, Bianca Moira Panizza, Alessandro Frattegiani, Martina Iacco, Anna Concetta Di Pilato, Simonetta Saldi, Cynthia Aristei
Background: Intensity-modulated radiotherapy (IMRT) improves dose distribution in head and neck (HN) radiation therapy. Volumetric-modulated arc therapy (VMAT), a new form of IMRT, delivers radiation in single or multiple arcs, varying dose rates (VDR-VMAT) and gantry speeds, has gained considerable attention. Constant dose rate VMAT (CDR-VMAT) associated with a fixed gantry speed does not require a dedicated linear accelerator like VDR-VMAT. The present study explored the feasibility, efficiency and delivery accuracy of CDR-VMAT, by comparing it with IMRT and VDR-VMAT in treatment planning for HN cancer...
May 2018: Reports of Practical Oncology and Radiotherapy
https://www.readbyqxmd.com/read/29726401/adaptation-of-stochastic-microdosimetric-kinetic-model-for-charged-particle-therapy-treatment-planning
#3
T Inaniwa, N Kanematsu
The microdosimetric kinetic (MK) model underestimates the cell-survival fractions for high linear energy transfer (LET) and high dose irradiations. To address the issue, some researchers previously extended the MK model to the stochastic microdosimetric kinetic (SMK) model. In the SMK model, the radiation induced cell-survival fractions were estimated from the specific energies z d and z n absorbed by a microscopic subnuclear structure domain and a cell nucleus, respectively. By taking the stochastic nature of z n as well as that of z d into account, the SMK model could reproduce the measured cell-survival fractions for radiations with wide LET and dose ranges...
May 4, 2018: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/29720332/standard-and-low-dose-cone-beam-computer-tomography-protocol-for-orthognatodontic-diagnosis-a-comparative-evaluation
#4
M Portelli, A Militi, A Lo Giudice, R Lo Giudice, R Fastuca, I Ielo, V Mongelli, G Lo Giudice, A Martintoni, M Manuelli, A Lucchese, R Nucera
Considering the diagnostic capability offered by cone-beam computed tomography (CBCT), nowadays orthodontists often use this exam for treatment planning, especially in cases of impacted teeth, maxillary ipoplasia, orthognathic surgery etc. The aim of this study was to compare the radiation doses related to a conventional CBCT setting and that of a low dose protocol, usable in orthodontic practice. The absorbed organ doses were measured using an anthropomorphic phantom loaded with thermo-luminescent dosimeters related to sensitive organs (brain, bone marrow, salivary glands, thyroid, esophagus, oral mucosa, extrathoracic airways, lymph nodes)...
March 2018: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/29703045/a-feasibility-and-safety-study-of-concurrent-chemotherapy-based-on-genetic-testing-in-patients-with-high-risk-salivary-gland-tumors-preliminary-results
#5
Rongrong Li, Shengjin Dou, Min Ruan, Chenping Zhang, Guopei Zhu
BACKGROUND: This prospective study was conducted to evaluate the feasibility and safety of customized chemotherapy regimens based on the gene characteristics of salivary gland tumors. METHODS: Patients were enrolled with histologically confirmed intermediate or high grade, stage T3-4, N1-3 disease, and T1-2, N0 patients with a close (≤1 mm) or microscopically positive surgical margin were also enrolled in the study. All patients received radical surgery and postoperative concurrent chemoradiotherapy...
April 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29696945/the-effect-of-chewing-gum-on-dose-rate-of-salivary-gland-in-differentiated-thyroid-carcinoma-patients-treated-with-radioiodine
#6
Mahdi Haghighatafshar, Reza Nowshad, Zahra Etemadi, Tahereh Ghaedian
BACKGROUND: Although, different methods have been suggested on reducing salivary gland radiation after radioiodine administration, an effective preventive or therapeutic measure is still debateful. To the best of our knowledge this is the second study that aimed to evaluate the effect of chewing-gum as a sialagogue on the radioiodine content of salivary gland, and radioiodine- induced symptoms of salivary gland dysfunction. METHODS: Twenty two patients who were referred to radioiodine therapy were randomized into chewing-gum (group A) and control (group B) groups...
April 26, 2018: Quarterly Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29688951/prediction-of-normal-organ-absorbed-doses-for-177lu-lu-psma-617-using-44sc-sc-psma-617-pharmacokinetics-in-patients-with-metastatic-castration-resistant-prostate-carcinoma
#7
Ambreen Khawar, Elisabeth Eppard, Jean Phlippe Sinnes, Frank Roesch, Hojjat Ahmadzadehfar, Stefan Kürpig, Michael Meisenheimer, Florian C Gaertner, Markus Essler, Ralph A Bundschuh
In vivo pharmacokinetic analysis of [Sc]Sc-PSMA-617 was used to determine the normal organ-absorbed doses that may result from therapeutic activity of [Lu]Lu-PSMA-617 and to predict the maximum permissible activity of [Lu]Lu-PSMA-617 for patients with metastatic castration-resistant prostate carcinoma. METHODS: Pharmacokinetics of [Sc]Sc-PSMA-617 was evaluated in 5 patients with metastatic castration-resistant prostate carcinoma using dynamic PET/CT, followed by 3 static PET/CT acquisitions and blood sample collection over 19...
April 23, 2018: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/29688836/pediatric-salivary-cancer-epidemiology-treatment-trends-and-association-of-treatment-modality-with-survival
#8
Elliot Morse, Rance J T Fujiwara, Zain Husain, Benjamin Judson, Saral Mehra
Objective To characterize the epidemiology of pediatric salivary cancer and associate patient, tumor, and treatment factors with treatment modality and survival. Study Design Cross-sectional analysis. Setting US national database. Subjects and Methods We identified 588 patients 19 years or younger diagnosed with salivary cancer in the National Cancer Database 2004-2013. We characterized patient, tumor, and treatment factors as proportions and associated these factors with treatment modality and overall survival via multivariable logistic regression and multivariable Cox proportional hazards regression, respectively...
April 1, 2018: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/29679075/apkc%C3%AE-dependent-repression-of-yap-is-necessary-for-functional-restoration-of-irradiated-salivary-glands-with-igf-1
#9
Alejandro M Chibly, Wen Yu Wong, Maricela Pier, Hongqiang Cheng, Yongxin Mu, Ju Chen, Sourav Ghosh, Kirsten H Limesand
Xerostomia and salivary hypofunction often result as a consequence of radiation therapy for head and neck cancers, which are diagnosed in roughly 60,000 individuals every year in the U.S. Due to the lack of effective treatments for radiation-induced salivary hypofunction, stem cell-based therapies have been suggested to regenerate the irradiated salivary glands. Pharmacologically, restoration of salivary gland function has been accomplished in mice by administering IGF-1 shortly after radiation treatment, but it is not known if salivary stem and progenitor cells play a role...
April 20, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29678523/safety-and-efficacy-of-mesenchymal-stem-cells-for-radiation-induced-xerostomia-a-randomized-placebo-controlled-phase-1-2-trial-mesrix
#10
Christian Grønhøj, David H Jensen, Peter Vester-Glowinski, Siri Beier Jensen, Allan Bardow, Roberto S Oliveri, Lea Munthe Fog, Lena Specht, Carsten Thomsen, Sune Darkner, Michael Jensen, Vera Müller, Katalin Kiss, Tina Agander, Elo Andersen, Anne Fischer-Nielsen, Christian von Buchwald
BACKGROUND: Salivary gland hypofunction and xerostomia are major complications to head and neck radiotherapy. This trial assessed the safety and efficacy of adipose tissue-derived mesenchymal stem cell (ASC) therapy for radiation-induced xerostomia. PATIENT AND METHODS: This randomized, placebo-controlled phase 1/2 trial included 30 patients, randomized in a 1:1 ratio to receive ultrasound-guided transplantation of ASCs or placebo to the submandibular glands. Patients had previously received radiotherapy for a T1-2, N0-2A, human papillomavirus-positive, oropharyngeal squamous cell carcinoma...
March 6, 2018: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/29668308/ultrasound-elastography-in-diagnosis-and-follow-up-for-patients-with-sialolithiasis
#11
Christoph A Reichel, Teresa Vincek, Donata Gellrich, Florian Schrötzlmair, Dirk Clevert, Pamela Zengel
OBJECTIVE: This study aims to answer whether Acoustic Radiation Force Impulse Imaging (ARFI) can reasonably be employed in initial examination and follow-up during therapy in patients with sialolithiasis, one of the most common non-malignant disorders of the salivary glands. METHODS: Mechanical tissue properties of affected and contralateral healthy salivary glands were analyzed by ARFI in 129 patients with sialolithiasis. In different subgroup analyses, ARFI shear wave velocity values were compared between healthy and diseased submandibular or parotid glands, salivary glands with calculi exhibiting different sizes, as well as before and after therapy...
April 18, 2018: Dento Maxillo Facial Radiology
https://www.readbyqxmd.com/read/29663717/salivary-gland-stem-cells-a-review-of-development-regeneration-and-cancer
#12
REVIEW
Elaine Emmerson, Sarah M Knox
Salivary glands are responsible for maintaining the health of the oral cavity and are routinely damaged by therapeutic radiation for head and neck cancer as well as by autoimmune diseases such as Sjögren's syndrome. Regenerative approaches based on the reactivation of endogenous stem cells or the transplant of exogenous stem cells hold substantial promise in restoring the structure and function of these organs to improve patient quality of life. However, these approaches have been hampered by a lack of knowledge on the identity of salivary stem cell populations and their regulators...
April 16, 2018: Genesis: the Journal of Genetics and Development
https://www.readbyqxmd.com/read/29655708/salivary-flow-rate-after-conventional-and-intensity-modulated-radiation-therapy
#13
Caroline Tram Nguyen, Spencer Lin, Haley Clark, Allan Hovan, Jonn Wu
BACKGROUND: Conventional 3-dimensional conformal radiation therapy (3DCRT) for head and neck cancer (HNC) can cause hyposalivation, leading to caries and tooth extraction-related osteoradionecrosis. Intensity-modulated radiation therapy (IMRT) delivers more focused radiation than does 3DCRT. To reduce hyposalivation, the Quantitative Analysis of Normal Tissue Effects in the Clinic (QUANTEC) guidelines limit salivary gland radiation dose. In this study, the authors compared the salivary flow rate in patients receiving 3DCRT and those receiving IMRT and evaluated the effect of their treatment satisfying the QUANTEC guidelines on hyposalivation...
April 11, 2018: Journal of the American Dental Association
https://www.readbyqxmd.com/read/29622117/routine-and-advanced-diffusion-imaging-modules-of-the-salivary-glands
#14
REVIEW
Ahmed Abdel Khalek Abdel Razek
This article reviews the role of routine and advanced diffusion imaging modules of the salivary glands. Routine and advanced diffusion imaging modules have a role in differentiation of malignant from benign salivary gland tumors, characterization of some benign salivary gland tumors, and staging of salivary gland cancer. The role of advanced diffusion modules in patients with salivary gland cancer after surgery, radiation therapy, or radioiodine therapy is discussed. Advanced diffusion imaging modules can help in diagnosis and staging of Sjögren syndrome...
May 2018: Neuroimaging Clinics of North America
https://www.readbyqxmd.com/read/29596382/mesenchymal-cells-affect-salivary-epithelial-cell-morphology-on-pgs-plga-core-shell-nanofibers
#15
Lauren Sfakis, Tim Kamaldinov, Alexander Khmaladze, Zeinab F Hosseini, Deirdre A Nelson, Melinda Larsen, James Castracane
Engineering salivary glands is of interest due to the damaging effects of radiation therapy and the autoimmune disease Sjögren's syndrome on salivary gland function. One of the current problems in tissue engineering is that in vitro studies often fail to predict in vivo regeneration due to failure of cells to interact with scaffolds and of the single cell types that are typically used for these studies. Although poly (lactic co glycolic acid) (PLGA) nanofiber scaffolds have been used for in vitro growth of epithelial cells, PLGA has low compliance and cells do not penetrate the scaffolds...
March 29, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29594057/thyroid-cancer-induction-nitrates-as-independent-risk-factors-or-risk-modulators-after-radiation-exposure-with-a-focus-on-the-chernobyl-accident
#16
REVIEW
Valentina M Drozd, Igor Branovan, Nikolay Shiglik, Johannes Biko, Christoph Reiners
In recent decades, differentiated thyroid cancer (DTC) incidence has been increasing worldwide. The important contributions to this phenomenon of "overdiagnosis" driven by wider use of improved ultrasound systems are amply documented, notwithstanding the "real" carcinogenic effects of ionizing radiation, e.g., from the Chernobyl accident or health care interventions. Less well understood is the role of nitrates - as environmental pollutants, in diet, and in medication - in thyroid carcinogenesis...
March 2018: European Thyroid Journal
https://www.readbyqxmd.com/read/29590144/administration-of-growth-factors-promotes-salisphere-formation-from-irradiated-parotid-salivary-glands
#17
Vicky T Nguyen, Peter Dawson, Qionghui Zhang, Zoey Harris, Kirsten H Limesand
Worldwide, 500,000 cases of head and neck cancer (HNC) are reported each year and the primary treatment for HNC is radiotherapy. Although the goal of radiotherapy is to target the tumor, secondary exposure occurs in surrounding normal tissues, such as the salivary glands. As a result, despite successful treatment of the cancer, patients are left with long-term side effects due to direct damage to the salivary glands. The effect is chronic and currently there is no treatment. Stem cells are an attractive therapeutic option for treatment of radiation-induced glandular dysfunction because of the potential to regenerate damaged cell populations and restore salivary gland function...
2018: PloS One
https://www.readbyqxmd.com/read/29572856/the-relative-biological-effectiveness-for-carbon-nitrogen-and-oxygen-ion-beams-using-passive-and-scanning-techniques-evaluated-with-fully-3d-silicon-microdosimeters
#18
Linh T Tran, David Bolst, Susanna Guatelli, Alex Pogossov, Marco Petasecca, Michael L F Lerch, Lachlan Chartier, Dale A Prokopovich, Mark I Reinhard, Marco Povoli, Angela Kok, Vladimir L Perevertaylo, Naruhiro Matsufuji, Tatsuaki Kanai, Michael Jackson, Anatoly B Rosenfeld
BACKGROUND: The aim of this study was to measure the microdosimetric distributions of a carbon pencil-beam scanning (PBS) and passive scattering system as well as to evaluate the relative biological effectiveness (RBE) of different ions, namely12 C,14 N and16 O, using a silicon-on-insulator (SOI) microdosimeter with well-defined 3D sensitive volumes (SV). Geant4 simulations were performed with the same experimental setup and results were compared to the experimental results for benchmarking...
March 23, 2018: Medical Physics
https://www.readbyqxmd.com/read/29569726/xerostomia-salivary-characteristics-and-gland-volumes-following-intensity-modulated-radiotherapy-for-nasopharyngeal-carcinoma-two-year-follow-up
#19
Christina P C Sim, Yoke-Lim Soong, Eric P P Pang, Cindy Lim, Glenn D Walker, David J Manton, Eric C Reynolds, Joseph T S Wee
BACKGROUND: To evaluate changes in xerostomia status, salivary characteristics and gland volumes two years following radiotherapy in nasopharyngeal carcinoma patients. METHODS: Xerostomia scores, salivary flow rates, pH and buffering capacity were measured at pre-radiotherapy, mid-radiotherapy, two-weeks, three-months and two-years post-radiotherapy. Salivary gland volumes and their correlation with radiation dose were also assessed. RESULTS: Mean radiation dose to oral cavity, parotid and submandibular glands was 44...
March 23, 2018: Australian Dental Journal
https://www.readbyqxmd.com/read/29568026/insufficient-evidence-for-interventions-to-prevent-dry-mouth-and-salivary-gland-dysfunction-post-head-and-neck-radiotherapy
#20
Debra M Ferraiolo, Analia Veitz-Keenan
Data sourcesCochrane Oral Health's Trials Register, the Cochrane Central Register of Controlled Trials (CENTRAL), Medline, Embase, CINAHL, EBSCO (Cumulative Index to Nursing and Allied Health Literature, LILACS, BIREME, Virtual Health Library (Latin American and Caribbean Health Science Information database), Zetoc Conference Proceedings, the US National Institutes of Health Ongoing Trials Register, (ClinicalTrials.gov) and the World Health Organization International Clinical Trials Registry Platform for ongoing trials...
March 23, 2018: Evidence-based Dentistry
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