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Radiation and salivary gland

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https://www.readbyqxmd.com/read/28721884/dosimetric-predictors-of-patient-reported-xerostomia-and-dysphagia-with-deintensified-chemoradiation-therapy-for-hpv-associated-oropharyngeal-squamous-cell-carcinoma
#1
Bhishamjit S Chera, David Fried, Alex Price, Robert J Amdur, William Mendenhall, Chiray Lu, Shiva Das, Nathan Sheets, Lawrence Marks, Panayiotis Mavroidis
PURPOSE/OBJECTIVE(S): To estimate the association between different dose-volume metrics of the salivary glands and pharyngeal constrictors with patient reported severity of xerostomia/dysphagia in the setting of deintensified chemoradiation therapy (CRT). METHODS AND MATERIALS: Forty-five patients were treated on a phase 2 study assessing the efficacy of deintensified CRT for favorable-risk, HPV-associated oropharyngeal squamous cell carcinoma. Patients received 60 Gy intensity modulated radiation therapy with concurrent weekly cisplatin (30 mg/m(2)), and reported the severity of their xerostomia/dysphagia (before and after treatment) using the patient-reported outcome version of the Common Terminology Criteria for Adverse Events (CTCAE) (PRO-CTCAE)...
August 1, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28714550/optimal-timing-and-frequency-of-bone-marrow-soup-therapy-for-functional-restoration-of-salivary-gland-injured-by-single-dose-or-fractionated-irradiation
#2
Dongdong Fang, Sixia Shang, Younan Liu, Mohammed Bakkar, Yoshinori Sumita, Jan Seuntjens, Simon D Tran
Injections of bone marrow (BM) cell extract, known as "BM Soup", was previously reported to mitigate ionizing radiation (IR) injury to salivary glands (SGs). However the optimal starting time and frequency to maintain BM Soup therapeutic efficacy remains unknown. This study tests the optimal starting time and frequency of BM Soup injections in mice radiated with either a single dose or fractionated dose. First, BM Soup treatment is started at 1, 3, or 7 weeks post-IR, while positive (non-IR) and negative (IR) control mice receive injections of saline (vehicle control)...
July 17, 2017: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/28712533/dose-volume-toxicity-modeling-for-de-intensified-chemo-radiation-therapy-for-hpv-positive-oropharynx-cancer
#3
Panayiotis Mavroidis, Alex Price, David Fried, Mark Kostich, Robert Amdur, William Mendenhall, Chihray Liu, Shiva Das, Lawrence B Marks, Bhishamjit Chera
BACKGROUND AND PURPOSE: The aim is to determine the radiobiological parameters of four popular normal tissue complication probability (NTCP) models that describe the dose-response relations of salivary glands and pharyngeal constrictors to the severity of patient reported xerostomia and dysphagia, respectively 6 and 12months post chemo-radiotherapy, furthermore, to evaluate the goodness-of-fit of the NTCP models for different combinations of glands and constrictors. MATERIAL AND METHODS: Forty-three patients were treated on a prospective multi-institutional phase II study (ClinicalTrials...
July 13, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/28708300/radioprotective-effect-of-thymoquinone-on-salivary-gland-of-rats-exposed-to-total-cranial-irradiation
#4
Mehmet Akyuz, Seyithan Taysi, Elif Baysal, Elif Demir, Hilal Alkis, Muslum Akan, Habip Binici, Zeynel Abidin Karatas
BACKGROUND: The purpose of this study was to investigate the radioprotective effects of thymoquinone against radiation-induced damage in the salivary glands of rats exposed to total cranial gamma irradiation. METHODS: Thirty-two Sprague-Dawley rats were divided into 4 groups to test the radioprotective effectiveness of thymoquinone by intraperitoneal injection. An appropriate control group was also studied. Biochemical parameters in liver tissue of rats were determined by spectrophotometer...
July 14, 2017: Head & Neck
https://www.readbyqxmd.com/read/28707525/is-there-a-role-for-ultrasound-guided-sialoplasty-in-the-management-of-salivary-duct-strictures
#5
Jimmy Makdissi, Lee Feinberg, Amit Roy
Ductal stricture is a common cause of obstructive salivary gland disease. Balloon dilatation of the parotid duct as a minimally invasive technique is currently carried out under fluoroscopic guidance or during sialendocopy. We present a case report of ultrasound guided balloon dilatation. A 45 year old lady presented with a long history of obstructive symptoms affecting the right parotid gland. Ultrasound examination revealed a tortuous right main parotid duct with marked dilatation throughout its course and multiple sites of focal stricture formation...
July 14, 2017: Dento Maxillo Facial Radiology
https://www.readbyqxmd.com/read/28705916/biodistribution-and-dosimetry-of-18-f-meta-fluorobenzyl-guanidine-mfbg-a-first-in-human-pet-ct-imaging-study-of-patients-with-neuroendocrine-malignancies
#6
Neeta Pandit-Taskar, Pat B Zanzonico, Kevin D Staton, Jorge A Carrasquillo, Diane Reidy-Lagunes, Serge K Lyashchenko, Eva Burnazi, Hanwen Zhang, Jason S Lewis, Ronald Blasberg, Steven M Larson, Wolfgang Andreas Weber, Shakeel Modak
Introduction: Iodine-123-meta-iodobenzylguanidine ((123)I-MIBG) imaging is currently a mainstay in the evaluation of many neuroendocrine tumors, especially neuroblastoma. (123)I-MIBG imaging has several limitations that can be overcome by the use of a PET agent. (18)F-MFBG is a positron emission tomography (PET) analog of MIBG that may allow for single-day, high-resolution quantitative imaging. We conducted a first-in-human study of (18)F-MFBG PET imaging to evaluate the safety, feasibility, pharmacokinetics, and dosimetry of (18)F-MFBG in neuroendocrine tumors (NETs)...
July 13, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/28678820/effect-of-reduced-z-axis-scan-coverage-on-diagnostic-performance-and-radiation-dose-of-neck-computed-tomography-in-patients-with-suspected-cervical-abscess
#7
Jakob Weiss, Michael Maurer, Dominik Ketelsen, Mike Notohamiprodjo, Dominik Zinsser, Julian L Wichmann, Konstantin Nikolaou, Fabian Bamberg, Ahmed E Othman
PURPOSE: To evaluate the effect of reduced z-axis scan coverage on diagnostic performance and radiation dose of neck CT in patients with suspected cervical abscess. METHODS: Fifty-one patients with suspected cervical abscess were included and underwent contrast-enhanced neck CT on a 2nd or 3rd generation dual-source CT system. Image acquisition ranged from the aortic arch to the upper roof of the frontal sinuses (CTstd). Subsequently, series with reduced z-axis coverage (CTred) were reconstructed starting at the aortic arch up to the orbital floor...
2017: PloS One
https://www.readbyqxmd.com/read/28678755/radiation-therapy-and-serum-salivary-amylase-in-head-and-neck-cancer
#8
REVIEW
Francesca De Felice, Mario Tombolini, Angela Musella, Francesco Marampon, Vincenzo Tombolini, Daniela Musio
Radiation therapy (RT) is a valid treatment option for head and neck cancer (HNC). The risk of RT-induced toxicities is significant, especially due to extended treatment fields. The raise in amylase activity is strictly dependent on the volume of salivary glands included in the irradiated target volume and it is firmly related to the dose. The aim of this review is to report the effects on salivary amylase activity after radiation exposure of salivary glands, in patients with HNC.
June 28, 2017: Oncotarget
https://www.readbyqxmd.com/read/28675085/impact-of-adjuvant-radiotherapy-for-malignant-salivary-gland-tumors
#9
Joseph Safdieh, Babak Givi, Virginia Osborn, Ariel Lederman, David Schwartz, David Schreiber
Objective Using the National Cancer Database (NCDB), we investigated the characteristics, outcomes, and benefits of adjuvant therapy for patients diagnosed with malignant salivary gland tumors between 2004 and 2012. Study Design Retrospective analysis. Setting NCDB. Subject and Methods The cases of patients diagnosed with a nonmetastatic major salivary gland tumor who underwent resection between 2004 and 2012 were abstracted from the NCDB. Patients were further included if they had pT1-4NX-1M0 high-grade disease or pT3-4NX-0M0 or pT1-4N1M0 low-grade disease...
June 1, 2017: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/28659312/radiosensitization-of-adenoid-cystic-carcinoma-with-mdm2-inhibition
#10
Prashanth J Prabakaran, Amal M Javaid, Adam D Swick, Lauryn R Werner, Kwangok P Nickel, Emmanuel Sampene, Rong Hu, Irene M Ong, Justine Y Bruce, Gregory K Hartig, Aaron Wieland, Jude Canon, Paul M Harari, Randall J Kimple
Adenoid cystic carcinoma (ACC) is a rare cancer arising from the major or minor salivary gland tissues of the head and neck. There are currently no approved systemic agents or known radiosensitizers for ACC. Unlike the more common head and neck squamous cell carcinomas that frequently harbor TP53 mutations, ACC contain TP53 mutations at a rate of <5%, rendering them an attractive target for MDM2 inhibition. <p>Experimental Design: We report the successful establishment and detailed characterization of a TP53-WT ACC patient derived xenograft (PDX) which retained the histologic features of the original patient tumor...
June 28, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/28658925/effect-of-cell-phone-radiations-on-orofacial-structures-a-systematic-review
#11
REVIEW
Sunil Kumar Mishra, Ramesh Chowdhary, Shail Kumari, Srinivasa B Rao
INTRODUCTION: The widespread use of cell phone in recent years has raised many questions whether their use is safe to operator who is exposed to Electromagnetic Waves (EMV). AIM: To find out the effect of cell phone emitted radiations on the orofacial structures. MATERIALS AND METHODS: To identify suitable literature, an electronic search was performed using Medline, Pubmed and EBSCO host database in December 2016. The search was focused on effect of cell phone on orofacial structures...
May 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28650891/pretreatment-primary-tumor-suvmax-on-18f-fdg-pet-ct-images-predicts-outcomes-in-patients-with-salivary-gland-carcinoma-treated-with-definitive-intensity-modulated-radiation-therapy
#12
Cheng-En Hsieh, Kung-Chu Ho, Chia-Hsun Hsieh, Tzu-Chen Yen, Chun-Ta Liao, Hung-Ming Wang, Chien-Yu Lin
PURPOSE: The aim of this study was to investigate the prognostic significance of F-FDG uptake in salivary gland carcinoma (SGC) patients treated with definitive intensity-modulated radiation therapy (IMRT). METHODS: We retrospectively examined 46 SGC patients who received pretreatment F-FDG PET/CT and definitive IMRT between 2007 and 2014. Most tumors were located in the minor salivary glands (n = 35 [76%]). Forty-six percent (n = 21) of the participants had unresectable disease...
June 24, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28640094/effects-of-first-radioiodine-ablation-on-functions-of-salivary-glands-in-patients-with-differentiated-thyroid-cancer
#13
Arun Upadhyaya, Zhaowei Meng, Peng Wang, Guizhi Zhang, Qiang Jia, Jian Tan, Xue Li, Tianpeng Hu, Na Liu, Pingping Zhou, Sen Wang, Xiaoxia Liu, Huiying Wang, Chunmei Zhang, Fengxiao Zhao, Ziyu Yan
The aim of this study was to evaluate the effects of the first radioactive iodine (I) therapy on functions of salivary glands in patients with differentiated thyroid carcinoma (DTC).There were 36 consented patients with DTC enrolled in this study, who received 3.7 GBq (100mCi) I for ablation after total thyroidectomy. Salivary gland function was assessed using salivary gland scintigraphy in two phases, one 4 hours before and the other 6 months after I therapy (both under thyrotropin stimulation condition)...
June 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28637715/tyrosine-kinase-inhibitors-protect-the-salivary-gland-from-radiation-damage-by-inhibiting-activation-of-protein-kinase-c-%C3%AE
#14
Sten M Wie, Elizabeth Wellberg, Sana D Karam, Mary E Reyland
In patients undergoing irradiation therapy, injury to non-tumor tissues can result in debilitating, and sometimes permanent, side effects. We have defined Protein Kinase C-delta (PKCδ) as a regulator of DNA damage induced apoptosis and have shown that phosphorylation of PKCδ by c-Abl and c-Src activates its pro-apoptotic function.  Here we have explored the use of tyrosine kinase inhibitors (TKIs) of c-Src and c-Abl to block activation of PKCδ for radioprotection of the salivary gland.  Dasatinib, imatinib, and bosutinib all suppressed tyrosine phosphorylation of PKCδ and inhibited IR-induced apoptosis in vitro  To determine if TKIs can provide radioprotection of salivary gland function in vivo, mice were treated with TKIs and a single or fractionated doses of irradiation...
June 21, 2017: Molecular Cancer Therapeutics
https://www.readbyqxmd.com/read/28588084/highlight-understanding-radiation-sialadenitis
#15
Michael B Yaffe
A nonapoptotic function of caspase-3 underlies the salivary gland complications of radiation therapy of head and neck cancers.
June 6, 2017: Science Signaling
https://www.readbyqxmd.com/read/28588083/science-signaling-podcast-for-6-june-2017-calcium-signaling-and-dry-mouth
#16
Indu Ambudkar, Annalisa M VanHook
This Podcast features a conversation with Indu Ambudkar, senior author of a Research Resource that appears in the 6 June 2017 issue of Science Signaling, about how activation of the cation channel TRPM2 is involved in radiation-induced dry mouth. Patients who receive radiation therapy for head and neck cancers often develop dry mouth as a side effect, and this condition is frequently permanent. Radiation does not kill cells in the salivary gland, yet it causes the acinar cells of the gland to reduce the amount of saliva they secrete...
June 6, 2017: Science Signaling
https://www.readbyqxmd.com/read/28588080/radiation-inhibits-salivary-gland-function-by-promoting-stim1-cleavage-by-caspase-3-and-loss-of-soce-through-a-trpm2-dependent-pathway
#17
Xibao Liu, Baijuan Gong, Lorena Brito de Souza, Hwei Ling Ong, Krishna P Subedi, Kwong Tai Cheng, William Swaim, Changyu Zheng, Yasuo Mori, Indu S Ambudkar
Store-operated Ca(2+) entry (SOCE) is critical for salivary gland fluid secretion. We report that radiation treatment caused persistent salivary gland dysfunction by activating a TRPM2-dependent mitochondrial pathway, leading to caspase-3-mediated cleavage of stromal interaction molecule 1 (STIM1) and loss of SOCE. After irradiation, acinar cells from the submandibular glands of TRPM2(+/+) , but not those from TRPM2(-/-) mice, displayed an increase in the concentrations of mitochondrial Ca(2+) and reactive oxygen species, a decrease in mitochondrial membrane potential, and activation of caspase-3, which was associated with a sustained decrease in STIM1 abundance and attenuation of SOCE...
June 6, 2017: Science Signaling
https://www.readbyqxmd.com/read/28583248/pediatric-phantom-dosimetry-of-kodak-9000-cone-beam-computed-tomography
#18
Juan F Yepes, Megan R Booe, Brian J Sanders, James E Jones, Ygal Ehrlich, John B Ludlow, Brandon Johnson
PURPOSE: The purpose of the study was to evaluate the radiation dose of the Kodak 9000 cone-beam computed tomography (CBCT) device for different anatomical areas using a pediatric phantom. METHODS: Absorbed doses resulting from maxillary and mandibular region three by five cm CBCT volumes of an anthropomorphic 10-year-old child phantom were acquired using optical stimulated dosimetry. Equivalent doses were calculated for radiosensitive tissues in the head and neck area, and effective dose for maxillary and mandibular examinations were calculated following the 2007 recommendations of the International Commission on Radiological Protection (ICRP)...
May 15, 2017: Pediatric Dentistry
https://www.readbyqxmd.com/read/28575794/-99m-tc-labeled-psma-inhibitor-biokinetics-and-radiation-dosimetry-in-healthy-subjects-and-imaging-of-prostate-cancer-tumors-in-patients
#19
Clara Santos-Cuevas, Jenny Davanzo, Guillermina Ferro-Flores, Francisco O García-Pérez, Blanca Ocampo-García, Eleazar Ignacio-Alvarez, Edgar Gómez-Argumosa, Martha Pedraza-López
The prostate-specific membrane antigen (PSMA) is expressed in epithelial cells of the prostate and highly overexpressed in 95% of advanced prostate cancers. The aims of this study was to estimate the biokinetics and dosimetry of (99m)Tc-EDDA/HYNIC-iPSMA ((99m)Tc-labeled PSMA inhibitor) in eight healthy subjects and evaluate its usefulness as a tumor-imaging agent in eight prostate cancer patients. METHODS: (99m)Tc-EDDA/HYNIC-iPSMA was obtained from a lyophilized formulation with radiochemical purities >98%, determined by reversed-phase HPLC and ITLC-SG analyses...
May 25, 2017: Nuclear Medicine and Biology
https://www.readbyqxmd.com/read/28530137/intravoxel-incoherent-motion-magnetic-resonance-imaging-of-the-normal-appearing-parotid-glands-in-patients-with-differentiated-thyroid-cancer-after-radioiodine-therapy
#20
Jie Shen, Xiao-Quan Xu, Guo-Yi Su, Hao Hu, Hai-Bin Shi, Wei Liu, Fei-Yun Wu
Background Radiation damage to the salivary gland is a common complication of radioiodine therapy (RIT) in the patients with differentiated thyroid cancer (DTC). Purpose To investigate the feasibility of using intravoxel incoherent motion (IVIM) magnetic resonance imaging (MRI) to detect radiation-induced changes of normal-appearing parotid glands in the patients after RIT for DTC. Material and Methods We prospectively enrolled 20 patients with RIT-induced sialoadenitis and 20 healthy control (HC) participants...
January 1, 2017: Acta Radiologica
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