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https://www.readbyqxmd.com/read/29682686/resolution-of-metastatic-colon-cancer-upon-withdrawal-of-anti-tnf-therapy-for-crohn-s-disease
#1
Bradley Wiksyk, Howard Joe, David Fenton, James K Kelly, Pauline T Truong
No abstract text is available yet for this article.
April 23, 2018: Journal of Gastrointestinal Cancer
https://www.readbyqxmd.com/read/29682493/the-frequency-of-clinic-visits-was-not-associated-with-medication-adherence-or-outcome-in-children-with-inflammatory-bowel-diseases
#2
Cheryl Kluthe, Jenkin Tsui, Donald Spady, Matthew Carroll, Eytan Wine, Hien Quoc Huynh
Background: Medication nonadherence is a challenge in pediatric patients with inflammatory bowel diseases (IBD). Poor adherence can result in disease flare-ups, disease complicationstherapy escalation, and the need for corticosteroids. The aim was to determine if clinic visit frequency was associated with treatment adherence. Methods: A retrospective chart review of patients attending the Edmonton Pediatric IBD Clinic (EPIC) at the Stollery Children's Hospital from January 2012 to December 2013 was completed...
2018: Canadian Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29681874/alexithymia-in-gastroenterology-and-hepatology-a-systematic-review
#3
Danilo Carrozzino, Piero Porcelli
Background: Alexithymia is a multifaceted personality construct that represents a deficit in the cognitive processing of emotions and is currently understood to be related to a variety of medical and psychiatric conditions. The present review aims to investigate the relationship of alexithymia with gastrointestinal (GI) disorders as functional gastrointestinal disorders (FGID, as irritable bowel syndrome (IBS) and functional dyspepsia) and inflammatory bowel disease (IBD) [ulcerative colitis (UC) and Crohn's disease (CD)] and liver diseases as chronic hepatitis C (CHC), cirrhosis, and liver transplantation...
2018: Frontiers in Psychology
https://www.readbyqxmd.com/read/29681789/alterations-in-lipid-amino-acid-and-energy-metabolism-distinguish-crohn-s-disease-from-ulcerative-colitis-and-control-subjects-by-serum-metabolomic-profiling
#4
Elizabeth A Scoville, Margaret M Allaman, Caroline T Brown, Amy K Motley, Sara N Horst, Christopher S Williams, Tatsuki Koyama, Zhiguo Zhao, Dawn W Adams, Dawn B Beaulieu, David A Schwartz, Keith T Wilson, Lori A Coburn
Introduction: Biomarkers are needed in inflammatory bowel disease (IBD) to help define disease activity and identify underlying pathogenic mechanisms. We hypothesized that serum metabolomics, which produces unique metabolite profiles, can aid in this search. Objectives: The aim of this study was to characterize serum metabolomic profiles in patients with IBD, and to assess for differences between patients with ulcerative colitis (UC), Crohn's disease (CD), and non- IBD subjects...
January 2018: Metabolomics: Official Journal of the Metabolomic Society
https://www.readbyqxmd.com/read/29676289/natural-history-and-outcome-of-inflammatory-bowel-diseases-in-children-in-saudi-arabia-a-single-center-experience
#5
Khalid M Alreheili, Khalid A Alsaleem, Ali I Almehaidib
Background/Aim: Inflammatory bowel disease (IBD) is a chronic gastrointestinal disorder which includes ulcerative colitis (UC), Crohn's disease (CD), and indeterminate colitis (IC). The natural history of pediatric IBDs is poorly understood and generally unpredictable. We aim to study the natural history of IBD in Saudi children including the extraintestinal manifestations, changes in diagnosis, disease behavior, medical management, and surgical outcome. Patients and Methods: A retrospective review of all the charts of children less than 14 years of age who were diagnosed as IBD and followed up in King Faisal Specialist Hospital and Research Center (KFSH and RC) from January 2001 to December 2011 was performed...
April 18, 2018: Saudi Journal of Gastroenterology: Official Journal of the Saudi Gastroenterology Association
https://www.readbyqxmd.com/read/29675304/identifying-intestinal-fibrosis-and-inflammation-by-spectroscopic-photoacoustic-imaging-an-animal-study-in-vivo
#6
Yunhao Zhu, Laura A Johnson, Ziyi Huang, Jonathan M Rubin, Jie Yuan, Hao Lei, Jun Ni, Xueding Wang, Peter D R Higgins, Guan Xu
Crohn's disease (CD) is a chronic autoimmune disease characterized by obstructing intestinal strictures. Conventional imaging modalities can identify the strictures but cannot characterize whether a stricture is predominantly inflammatory or fibrotic. The purpose of this study is to examine the capability of photoacoustic (PA) imaging to characterize intestinal fibrosis and inflammation in vivo . Intestinal strictures in a rat model of CD were imaged with a PA-ultrasound parallel imaging system. Internal and external illuminations were attempted, both with transcutaneous PA signal reception...
April 1, 2018: Biomedical Optics Express
https://www.readbyqxmd.com/read/29674398/intestinal-granulomatous-disease-what-is-the-first-call
#7
Alex Guri, Michal Kori, Pearl Herskovitz, Oren Zimhony
A 15-year-old girl presented with erythema nodosum and mild abdominal complaints. Her intestinal granulomatous disease was erroneously diagnosed as Crohn's disease despite the fact that the possibility of tuberculosis was considered. The final diagnosis of tuberculosis was made only when an anti-tumour necrosis factor therapy resulted in further deterioration. The patient was treated with isoniazid, rifampin, pyrazinamide and ethambutol, with slow and steady clinical improvement until complete recovery was achieved...
April 19, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29673210/bioelectrical-impedance-phase-angle-as-an-indicator-of-malnutrition-in-hospitalized-children-with-diagnosed-inflammatory-bowel-diseases-a-case-control-study
#8
Paweł Więch, Mariusz Dąbrowski, Dariusz Bazaliński, Izabela Sałacińska, Bartosz Korczowski, Monika Binkowska-Bury
The phase angle (PhA) seems to be a reliable screening tool for the identification of malnutrition risk in hospitalized children with inflammatory bowel disease (IBD). The aim of the present study was to assess the body composition and nutritional status of hospitalized children and adolescents with IBD by using bioelectrical impedance analysis (BIA) with phase angle (PhA) calculation, which has not been evaluated in hospitalized children with IBD yet. A total of 59 children and adolescents aged 4–18 years, with IBD: 34 ulcerative colitis (UC) and 25 Crohn’s disease (CD) were included in the study...
April 17, 2018: Nutrients
https://www.readbyqxmd.com/read/29673053/vedolizumab-as-a-rescue-therapy-for-patients-with-medically-refractory-crohn-s-disease
#9
Kristen T Crowell, Andrew Tinsley, Emmanuelle D Williams, Matthew D Coates, Anne Bobb, Walter A Koltun, Evangelos Messaris
AIM: Vedolizumab, a monoclonal antibody resulting in gut-selective anti-inflammatory activity, was FDA-approved in 2014 for use in patients with Crohn's disease (CD). The aim of the study was to investigate the efficacy of vedolizumab as a rescue therapy when other medical therapies have failed. METHOD: A retrospective review was performed on consecutive CD patients receiving vedolizumab between May 2014 and March 2016 at the Penn State Hershey IBD Center. These patients were unresponsive or intolerant to TNF antagonist therapy, and previously would have been surgical candidates...
April 19, 2018: Colorectal Disease: the Official Journal of the Association of Coloproctology of Great Britain and Ireland
https://www.readbyqxmd.com/read/29672874/review-article-novel-oral-targeted-therapies-in-inflammatory-bowel-disease
#10
REVIEW
J R White, F Phillips, T Monaghan, W Fateen, S Samuel, S Ghosh, G W Moran
BACKGROUND: There is a great unmet clinical need for efficacious, tolerable, economical and orally administrated drugs for the treatment of inflammatory bowel disease (IBD). New therapeutic avenues have become possible including the development of medications that target specific genetic pathways found to be relevant in other immune mediated diseases. AIMS: To provide an overview of recent clinical trials for new generation oral targeted medications that may have a future role in IBD management...
April 19, 2018: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/29672662/fibrostenotic-phenotype-of-myofibroblasts-in-crohn-s-disease-is-dependent-on-tissue-stiffness-and-reversed-by-lox-inhibition
#11
Jessica R de Bruyn, Gijs R van den Brink, Jessica Steenkamer, Christianne J Buskens, Willem A Bemelman, Sander Meisner, Vanesa Muncan, Anje A Te Velde, Geert R D'Haens, Manon E Wildenberg
Background and Aims: Crohn's disease is a chronic inflammatory disorder of the intestine and often leads to fibrosis, characterized by excess extracellular matrix [ECM] deposition, increased tissue stiffness, and stricture formation. Here we evaluated the contribution of myofibroblast-ECM interactions to the development of intestinal fibrosis in Crohn's disease. Methods: Matched primary human myofibroblasts were isolated from stenotic, inflamed and normal-appearing small intestine within the same Crohn's disease patient [n = 10]...
April 16, 2018: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/29672285/long-term-outcome-of-endoscopic-balloon-dilatation-for-strictures-in-patients-with-crohn-s-disease
#12
Takashi Taida, Tomoo Nakagawa, Yuki Ohta, Shinsaku Hamanaka, Kenichiro Okimoto, Keiko Saito, Daisuke Maruoka, Tomoaki Matsumura, Makoto Arai, Tatsuro Katsuno, Naoya Kato
BACKGROUND/AIMS: Endoscopic balloon dilatation (EBD) is an alternative to surgery for strictures in patients with Crohn's disease (CD). The aim of the present study was to clarify the efficacy and safety of EBD for strictures in patients with CD. METHODS: Twenty-six patients with CD who underwent EBD for strictures from August 2008 to November 2015 were followed up after dilatation. Short-term success was defined as the disappearance of obstructive symptoms after technically adequate dilatation was achieved...
April 19, 2018: Digestion
https://www.readbyqxmd.com/read/29671171/new-use-for-cetsa-monitoring-innate-immune-receptor-stability-via-post-translational-modification-by-ogt
#13
Walter R Drake, Ching-Wen Hou, Natasha E Zachara, Catherine Leimkuhler Grimes
O-GlcNAcylation is a dynamic and functionally diverse post-translational modification shown to affect thousands of proteins, including the innate immune receptor nucleotide-binding oligomerization domain-containing protein 2 (Nod2). Mutations of Nod2 (R702W, G908R and 1007 fs) are associated with Crohn's disease and have lower stabilities compared to wild type. Cycloheximide (CHX)-chase half-life assays have been used to show that O-GlcNAcylation increases the stability and response of both wild type and Crohn's variant Nod2, R702W...
April 18, 2018: Journal of Bioenergetics and Biomembranes
https://www.readbyqxmd.com/read/29670872/a-challenging-treatment-decision-for-a-rare-association-case-report-of-familial-turcot-syndrome-with-fistulizing-crohn-s-disease
#14
Montserrat Corbera-Hincapie, Genie L Beasley
Turcot syndrome and fistulizing Crohn's disease (CD) are two disease entities that are not usually associated with one another, particularly given the rarity of the former. This is a case of a pediatric patient with fistulizing CD treated with biologic therapy, who was later found to have Turcot syndrome. Management of this rare combination of diseases can present several challenges, as surgical options may be limited and chronic immunosuppression to treat CD may lead to accelerated progression of malignancy in Turcot syndrome...
2018: Frontiers in Pediatrics
https://www.readbyqxmd.com/read/29670622/immune-reconstitution-after-autologous-hematopoietic-stem-cell-transplantation-in-crohn-s-disease-current-status-and-future-directions-a-review-on-behalf-of-the-ebmt-autoimmune-diseases-working-party-and-the-autologous-stem-cell-transplantation-in-refractory
#15
REVIEW
Alan Graham Pockley, James O Lindsay, Gemma A Foulds, Sergio Rutella, John G Gribben, Tobias Alexander, John A Snowden
Patients with treatment refractory Crohn's disease (CD) suffer debilitating symptoms, poor quality of life, and reduced work productivity. Surgery to resect inflamed and fibrotic intestine may mandate creation of a stoma and is often declined by patients. Such patients continue to be exposed to medical therapy that is ineffective, often expensive and still associated with a burden of adverse effects. Over the last two decades, autologous hematopoietic stem cell transplantation (auto-HSCT) has emerged as a promising treatment option for patients with severe autoimmune diseases (ADs)...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29670513/altered-brain-excitability-and-increased-anxiety-in-mice-with-experimental-colitis-consideration-of-hyperalgesia-and-sex-differences
#16
Kewir D Nyuyki, Nina L Cluny, Mark G Swain, Keith A Sharkey, Quentin J Pittman
Crohn's disease (CD) and ulcerative colitis (UC) are incurable lifelong inflammatory bowel diseases (IBD) with a rising worldwide incidence. IBD is characterized by diarrhea, rectal bleeding, severe cramping and weight loss. However, there is a growing evidence that IBD is also associated with anxiety- and depression-related disorders, which further increase the societal burden of these diseases. Given the limited knowledge of central nervous system (CNS) changes in IBD, we investigated CNS-related comorbidities in a mouse model of experimental colitis induced by dextran sulfate sodium (DSS) administration in drinking water for 5 days...
2018: Frontiers in Behavioral Neuroscience
https://www.readbyqxmd.com/read/29669068/adverse-reactions-after-intravenous-iron-infusion-among-inflammatory-bowel-disease-patients-in-the-united-states-2010-2014
#17
Eboselume Akhuemonkhan, Alyssa Parian, Kathryn A Carson, Susan Hutfless
Background: Anemia is a frequent complication of Crohn's disease (CD) and ulcerative colitis (UC), collectively known as inflammatory bowel disease (IBD). Intravenous (IV) iron is recommended as the initial therapy for patients with clinically active IBD, severe anemia, and intolerance to oral iron. IV iron is associated with serious adverse effects including a black box warning for anaphylaxis with iron dextran and ferumoxytol. We aimed to examine the occurrence of adverse reactions including anaphylaxis after IV iron infusions in a large database of US IBD patients...
April 13, 2018: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/29669023/the-relevance-of-vitamin-and-iron-deficiency-in-patients-with-inflammatory-bowel-diseases-in-patients-of-the-swiss-ibd-cohort
#18
Matiar Madanchi, Stefania Fagagnini, Nicolas Fournier, Luc Biedermann, Jonas Zeitz, Edouard Battegay, Lukas Zimmerli, Stephan R Vavricka, Gerhard Rogler, Michael Scharl
Background andAims: Vitamin and iron deficiencies are common in patients with inflammatory bowel disease (IBD) as a result of chronic intestinal inflammation, increase in demand, or dietary restrictions. Here, we assessed the frequency of complications in relation to deficiency of iron, folate acid, and vitamin B12 in patients enrolled in the nationwide Swiss Inflammatory Bowel Disease Cohort Study (SIBDCS). Methods: A total of 2666 patients were included in the study, 1558 with Crohn's disease (CD) and 1108 with ulcerative colitis (UC)...
April 13, 2018: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/29669006/gene-signature-based-approach-identified-mek1-2-as-a-potential-target-associated-with-relapse-after-anti-tnf%C3%AE-treatment-for-crohn-s-disease
#19
Kanae Gamo, Yuumi Okuzono, Masato Yabuki, Takashi Ochi, Kyoko Sugimura, Yosuke Sato, Masaki Sagara, Hiroki Hayashi, Yoshimasa Ishimura, Yutaka Nishimoto, Yusuke Murakawa, Zenyu Shiokawa, Masayuki Gotoh, Takahiro Miyazaki, Yukihiko Ebisuno
Background: Anti-tumor necrosis factor alpha (anti-TNFα) therapy has become the mainstay of therapy for Crohn's disease (CD). However, post-therapy, the recurrence rate is still high. The aim of this study was to dissect the molecular mechanism for recurrence of CD treated with anti-TNFα therapy and investigate novel therapeutic options that could induce complete remission. Methods: We re-analyzed publicly available mucosal gene expression data from CD patients pre- and post-infliximab therapy to extract the transcriptional differences between responders and healthy controls...
April 13, 2018: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/29668998/methotrexate-and-thioguanine-rescue-therapy-for-conventional-thiopurine-failing-ulcerative-colitis-patients-a-multi-center-database-study-on-tolerability-and-effectiveness
#20
Berrie Meijer, Chris J J Mulder, Gerd Bouma, Cyriel Y Ponsioen, C Janneke van der Woude, Andrea E van der Meulen, Dion S J Wintjens, Gerard Dijkstra, Frank Hoentjen, Bas Oldenburg, Adriaan A van Bodegraven, Nanne K H de Boer
Background: Patients with active ulcerative colitis (UC) failing conventional therapies are in need of rescue strategies. Due to the fact that accepted step-up therapy with biologicals is expensive and sometimes unavailable, alternative therapies are warranted. Methotrexate (MTX) and thioguanine (TG) have both been suggested as alternative maintenance strategies in conventional thiopurine failing UC patients. In this multicenter database study, we compared safety and effectiveness (drug-survival) of MTX and TG in UC patients...
April 13, 2018: Inflammatory Bowel Diseases
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