keyword
MENU ▼
Read by QxMD icon Read
search

Crohn's

keyword
https://www.readbyqxmd.com/read/29029152/surgical-treatment-in-childhood-onset-inflammatory-bowel-disease-a-nationwide-register-based-study-of-4-695-incident-patients-in-sweden-2002-2014
#1
Caroline Nordenvall, Oda Rosvall, Matteo Bottai, Åsa H Everhov, Petter Malmborg, Karin E Smedby, Anders Ekbom, Johan Askling, Jonas F Ludvigsson, Pär Myrelid, Ola Olén
Background and Aims: The incidence of childhood-onset (<18 years) inflammatory bowel disease is increasing worldwide, and some studies suggest that it represents a more severe disease phenotype. Few nationwide, population-based studies have evaluated the surgical burden in patients with childhood-onset IBD, and whether the improved medical treatment has influenced the need for gastrointestinal surgery. The aim was to examine whether the surgical treatment at any age of patients with childhood-onset IBD has changed over time...
September 27, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/29029150/antibiotic-use-and-new-onset-inflammatory-bowel-disease-in-olmsted-county-minnesota-a-population-based-case-control-study
#2
Satimai Aniwan, William J Tremaine, Laura E Raffals, Sunanda V Kane, Edward V Loftus
Background and Aims: Several studies have suggested significant associations between environmental factors and the risk of developing inflammatory bowel disease (IBD). However, data supporting the role of antibiotics are conflicting. The aim of this study was to evaluate the association between antibiotic use and new-onset IBD. Methods: We conducted a population-based case-control study using the Rochester Epidemiology Project of Olmsted County, Minnesota. We identified 736 county residents diagnosed with IBD between 1980 and 2010 who were matched to 1472 controls, based on age, sex and date of IBD diagnosis...
September 28, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/29029098/genital-granulomatosis-in-male-and-female-patients-with-crohn-s-disease-clinical-presentation-and-treatment-outcomes
#3
F Dederichs, I Iesalnieks, M Sladek, Ch Tzivinikos, R Hansen, C Muñoz, P Pavli, M N Cavicchi, V Abitbol, J-F Rahier, S R Vavricka, K Katsanos, E Domènech
Background: Genital granulomatosis (GG) is a metastatic form of Crohn's Disease (CD), characterized by granulomatous inflammation of the genital skin without contact to the gastrointestinal tract. Little is known about GG as most publications are case reports or small series, and only sporadic in male cases. Methods and Aims: Cases of GG were retrospectively collected through the Collaborative Network For Exceptionally Rare case reports project of the European Crohn´s and Colitis Organization...
September 27, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/29028958/development-of-clinical-prediction-models-for-surgery-and-complications-in-crohn-s-disease
#4
Leonardo Guizzetti, Guangyong Zou, Reena Khanna, Parambir S Dulai, William J Sandborn, Vipul Jairath, Brian G Feagan
Background and Aims: Crohn's disease-related complications account for a substantial proportion of inflammatory bowel disease-associated healthcare expenditure. Identifying patients at risk for complications may allow for targeted use of early therapeutic interventions to off-set this natural course. We aimed to develop risk prediction models for Crohn's disease-related surgery and complications. Methods: Using data from the Randomized Evaluation of an Algorithm for Crohn's Disease cluster-randomized clinical Trial (REACT), which involved 1898 patients from 40 community practices...
September 19, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/29028817/mitochondrial-dysfunction-in-the-gastrointestinal-mucosa-of-children-with-autism-a-blinded-case-control-study
#5
Shannon Rose, Sirish C Bennuri, Katherine F Murray, Timothy Buie, Harland Winter, Richard Eugene Frye
Gastrointestinal (GI) symptoms are prevalent in autism spectrum disorder (ASD) but the pathophysiology is poorly understood. Imbalances in the enteric microbiome have been associated with ASD and can cause GI dysfunction potentially through disruption of mitochondrial function as microbiome metabolites modulate mitochondrial function and mitochondrial dysfunction is highly associated with GI symptoms. In this study, we compared mitochondrial function in rectal and cecum biopsies under the assumption that certain microbiome metabolites, such as butyrate and propionic acid, are more abundant in the cecum as compared to the rectum...
2017: PloS One
https://www.readbyqxmd.com/read/29028807/ulcerative-colitis-crohn-s-disease-and-irritable-bowel-syndrome-have-different-profiles-of-extracellular-matrix-turnover-which-also-reflects-disease-activity-in-crohn-s-disease
#6
Joachim Høg Mortensen, Tina Manon-Jensen, Michael Dam Jensen, Per Hägglund, Lone Gabriels Klinge, Jens Kjeldsen, Aleksander Krag, Morten Asser Karsdal, Anne-Christine Bay-Jensen
BACKGROUND: Increased protease activity is a key pathological feature of inflammatory bowel disease (IBD). However, the differences in extracellular matrix remodelling (ECM) in Crohn's disease (CD) and ulcerative colitis (UC) are not well described. An increased understanding of the inflammatory processes may provide optimized disease monitoring and diagnostics. We investigated the tissue remodelling in IBD and IBS patients by using novel blood-based biomarkers reflecting ECM remodelling...
2017: PloS One
https://www.readbyqxmd.com/read/29028149/solitary-perianal-rectal-mass-as-the-only-manifestation-of-crohn-s-disease
#7
Hu Dan Dan, Bei Tan, Jia Ming Qian
Crohn's disease (CD) is a chronic relapsing inflammatory disorder that can affect any part of the gastrointestinal tract, from mouth to anus. Bissell et al first described the regional enteritis with perianal disease in 1934(1) .
October 13, 2017: Journal of Digestive Diseases
https://www.readbyqxmd.com/read/29027693/efficacy-and-safety-of-golimumab-in-crohn-s-disease-a-french-national-retrospective-study
#8
C Martineau, B Flourié, P Wils, T Vaysse, R Altwegg, A Buisson, A Amiot, G P de Chambrun, V Abitbol, M Fumery, X Hébuterne, S Viennot, D Laharie, L Beaugerie, S Nancey, H Sokol
BACKGROUND: Anti-tumour necrosis factor (TNF) agents have improved the care of Crohn's disease (CD). After the first anti-TNF discontinuation, it is possible to switch to another anti-TNF. Three anti-TNF agents are available for ulcerative colitis (infliximab, adalimumab and golimumab), but only the first 2 have been approved for CD because golimumab has not been studied for this indication. AIM: To report the efficacy and safety of golimumab in CD. METHODS: Crohn's disease patients who received golimumab were identified in 12 French tertiary centres and were retrospectively analysed...
October 13, 2017: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/29027585/the-features-of-adipose-derived-stem-cells-in-patients-with-inflammatory-bowel-diseases
#9
Tsunekazu Mizushima, Tadafumi Fukata, Hiroshi Takeyama, Hidekazu Takahashi, Naotsugu Haraguchi, Junichi Nishimura, Taishi Hata, Chu Matsuda, Hirofumi Yamamoto, Yuichiro Doki, Masaki Mori
PURPOSE: The treatment outcomes for inflammatory bowel disease (IBD) have been improving, but the development of better therapies is needed. Stem cell therapy is promising, but little is known about the differences in adipose-derived stem cells (ADSCs) between IBD patients and healthy individuals. METHODS: ADSCs were isolated from subcutaneous adipose tissue (SAT) in IBD (Crohn's disease, 3; ulcerative colitis, 2) and non-IBD (colorectal cancer, 5; breast cancer, 1) patients...
October 12, 2017: Surgery Today
https://www.readbyqxmd.com/read/29027377/contribution-of-extracellular-matrix-and-signal-mechanotransduction-to-epithelial-cell-damage-in-inflammatory-bowel-disease-patients-a-proteomic-study
#10
Manuela Moriggi, Luca Pastorelli, Enrica Torretta, Gian Eugenio Tontini, Daniele Capitanio, Stefano Ferrero Bogetto, Maurizio Vecchi, Cecilia Gelfi
This study utilized 2D-DIGE, isotope-coded protein labelling (ICPL) and biochemical assays to characterize protein alteration in Ulcerative Colitis (UC) and Crohn's Disease (CD) in human epithelial cell and mucosal biopsies in Inflammatory Bowel Disease (IBD)-affected patients. The aim of this study is to identify the key molecular signatures involved in epithelial cell structure of IBDs. In non-inflamed UC (QUC) keratins, vimentin and FAK increased, whereas vinculin and de-tyrosinated α-tubulin decreased; inflammation (IUC) exacerbated molecular changes, being COL6A1, tenascin-C and vimentin increased...
October 13, 2017: Proteomics
https://www.readbyqxmd.com/read/29026838/tumor-necrosis-factor-alpha-antibodies-in-fistulizing-crohn-s-disease-an-updated-systematic-review-and-meta-analysis
#11
REVIEW
Pardis Zaboli, Mohammad Abdollahi, Shilan Mozaffari, Shekoufeh Nikfar
Medical treatment for fistulizing Crohn's disease (FCD) is changing rapidly over the time by the introduction of novel therapeutic medicines, while no global consensus is available. This study aims to accomplish a systematic review and meta-analysis on the efficacy of tumor necrosis factor-alpha antibodies (anti-TNF-α antibodies) versus placebo in FCD. A systematic review of published literature was carried out till December 2016, and a meta-analysis of identified studies was done. Data have been explored from PubMed, Scopus, Cochrane Library Database, and Web of Science...
July 2017: Journal of Research in Pharmacy Practice
https://www.readbyqxmd.com/read/29026602/re-phrasing-the-question-a-simple-tool-for-evaluation-of-adherence-to-therapy-in-patients-with-inflammatory-bowel-disease
#12
T Engel, B Ungar, G Ben-Haim, N Levhar, R Eliakim, S Ben-Horin
BACKGROUND: Non-adherence to medication in patients with inflammatory bowel disease (IBD) is a challenging problem which is often overlooked or under-estimated by the physician or denied by the patient. We aimed to examine if re-phrasing the wording of the question used by the physician could help in revealing more patients who are non-adherent, and for whom appropriate counseling may be instituted. METHODS: A cross-sectional questionnaire-based study of IBD patients treated in a tertiary center was conducted...
October 2017: United European Gastroenterology Journal
https://www.readbyqxmd.com/read/29026590/eosinophilic-esophagitis-what-can-we-learn-from-crohn-s-disease
#13
REVIEW
Javier Molina-Infante, Alain M Schoepfer, Alfredo J Lucendo, Evan S Dellon
Eosinophilic esophagitis (EoE) is an emerging esophageal inflammatory disorder affecting children and young adults. As a relatively new disease, EoE is still burdened by frequent diagnostic and therapeutic pitfalls in clinical practice. This manuscript posits a number of similarities with Crohn's disease, which may help optimize EoE patient management. Commonalities include epidemiologic trends (Westernized diseases, rising incidence, early-life risk factors), diagnostic considerations (symptoms are poor predictors of disease activity, difficulties in disease activity assessment) and therapeutic issues (similar natural history and therapeutic goals, induction and maintenance phases, combination of drug and endoscopic treatment, potential drug interchangeability, long-term unsolved issues)...
October 2017: United European Gastroenterology Journal
https://www.readbyqxmd.com/read/29026420/quality-of-life-in-inflammatory-bowel-disease-patients-a-cross-sectional-study
#14
Farzaneh Habibi, Mohammad Emadoddin Habibi, Ali Gharavinia, Sadegh Baradaran Mahdavi, Mohammad Javad Akbarpour, Abdolmehdi Baghaei, Mohammad Hassan Emami
BACKGROUND: Inflammatory bowel disease (IBD) has a significant impact on health-related quality of life (HRQOL). This study aims to investigate the variables which can be attributed to HRQOL in IBD patients. MATERIALS AND METHODS: Seventy-one patients filled in IBD questionnaire (IBDQ-32), Pittsburgh sleep quality index questionnaire, and sociodemographic questionnaire. Disease activity was assessed by Crohn's disease activity index (CDAI) and ulcerative colitis activity index (UCAI)...
2017: Journal of Research in Medical Sciences: the Official Journal of Isfahan University of Medical Sciences
https://www.readbyqxmd.com/read/29026327/characterization-and-prevalence-of-spondyloarthritis-and-peripheral-arthritis-among-patients-with-inflammatory-bowel-disease
#15
Hoda M Malaty, Grace Hsiao-Wei Lo, Jason K Hou
BACKGROUND: Joint complaints such as spondyloarthritis and peripheral arthritis are the most common extraintestinal manifestations in patients with inflammatory bowel disease (IBD); however, the evaluation of these symptoms are poorly described. OBJECTIVES: To examine the clinical characteristics and prevalence of ankylosing spondylitis (AS) and other joint complaints among patients with IBD. METHODS: In a local cohort of patients diagnosed with IBD between 1996 and 2009, we performed a retrospective study at the Veterans Affairs Hospital...
2017: Clinical and Experimental Gastroenterology
https://www.readbyqxmd.com/read/29025009/crohn-s-disease-bamboo-joint-like-appearance
#16
Hiroki Matsuura, Hisae Yasuhara
No abstract text is available yet for this article.
August 23, 2017: QJM: Monthly Journal of the Association of Physicians
https://www.readbyqxmd.com/read/29024102/asian-organization-for-crohn-s-and-colitis-and-asia-pacific-association-of-gastroenterology-consensus-on-tuberculosis-infection-in-patients-with-inflammatory-bowel-disease-receiving-anti-tumor-necrosis-factor-treatment-part-2-management
#17
REVIEW
Dong Il Park, Tadakazu Hisamatsu, Minhu Chen, Siew Chien Ng, Choon Jin Ooi, Shu Chen Wei, Rupa Banerjee, Ida Normiha Hilmi, Yoon Tae Jeen, Dong Soo Han, Hyo Jong Kim, Zhihua Ran, Kaichun Wu, Jiaming Qian, Pin-Jin Hu, Katsuyoshi Matsuoka, Akira Andoh, Yasuo Suzuki, Kentaro Sugano, Mamoru Watanabe, Toshifumi Hibi, Amarender S Puri, Suk-Kyun Yang
Because anti-tumor necrosis factor (anti-TNF) therapy has become increasingly popular in many Asian countries, the risk of developing active tuberculosis (TB) among anti-TNF users may raise serious health problems in this region. Thus, the Asian Organization for Crohn's and Colitis and the Asia Pacific Association of Gastroenterology have developed a set of consensus statements about risk assessment, detection and prevention of latent TB infection, and management of active TB infection in patients with inflammatory bowel disease (IBD) receiving anti-TNF treatment...
October 10, 2017: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29023984/partial-to-complete-abrogation-of-the-sub-epithelial-macrophage-barrier-against-the-gut-microbiota-in-patients-with-ulcerative-colitis-and-crohn-s-colitis
#18
Carlos A Rubio, Cord Langner, Peter T Schmidt
AIMS: The integrity of the subepithelial band of indigenous macrophages in the lamina-propria (SLP-MΦ) is crucial in deterring the commensal gut-microbiota from host-assailment. The breakdown of the SLP-MΦ barrier results in microbiota inflow and improper immune responses; this might lead to IBD. During inflammation, the SLP-MΦ-barrier is reinforced by inflammation-elicited MΦ (IEMΦ, derived from blood-circulating monocytes). The aim was to explore the characteristics of the SLP-MΦ band in a cohort of biopsies without inflammation, in patients with ulcerative colitis-in remission (UCre), and in patients with right-sided Crohn's colitis (RCC)...
October 11, 2017: Histopathology
https://www.readbyqxmd.com/read/29023903/asian-organization-for-crohn-s-and-colitis-and-asia-pacific-association-of-gastroenterology-consensus-on-tuberculosis-infection-in-patients-with-inflammatory-bowel-disease-receiving-anti-tumor-necrosis-factor-treatment-park-1-risk-assessment
#19
REVIEW
Dong Il Park, Tadakazu Hisamatsu, Minhu Chen, Siew Chien Ng, Choon Jin Ooi, Shu Chen Wei, Rupa Banerjee, Ida Normiha Hilmi, Yoon Tae Jeen, Dong Soo Han, Hyo Jong Kim, Zhihua Ran, Kaichun Wu, Jiaming Qian, Pin-Jin Hu, Katsuyoshi Matsuoka, Akira Andoh, Yasuo Suzuki, Kentaro Sugano, Mamoru Watanabe, Toshifumi Hibi, Amarender S Puri, Suk-Kyun Yang
Because anti-tumor necrosis factor (anti-TNF) therapy has become increasingly popular in many Asian countries, the risk of developing active tuberculosis (TB) among anti-TNF users may raise serious health problems in this region. Thus, the Asian Organization for Crohn's and Colitis and the Asia Pacific Association of Gastroenterology have developed a set of consensus statements about risk assessment, detection and prevention of latent TB infection, and management of active TB infection in patients with inflammatory bowel disease (IBD) receiving anti-TNF treatment...
October 10, 2017: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29023532/risk-factors-for-gallstones-and-kidney-stones-in-a-cohort-of-patients-with-inflammatory-bowel-diseases
#20
Stefania Fagagnini, Henriette Heinrich, Jean-Benoît Rossel, Luc Biedermann, Pascal Frei, Jonas Zeitz, Marianne Spalinger, Edouard Battegay, Lukas Zimmerli, Stephan R Vavricka, Gerhard Rogler, Michael Scharl, Benjamin Misselwitz
BACKGROUND: Gallstones and kidney stones are known complications of inflammatory bowel diseases (IBD). Risk factors have been insufficiently studied and explanatory studies date back up to 30 years. It remains unclear, whether improved treatment options also influenced risk factors for these complications. OBJECTIVES: Identifying risk factors for gallstones and kidney stones in IBD patients. METHODS: Using data from the Swiss Inflammatory Bowel Disease Cohort Study we assessed associations of diseases characteristics with gallstones and kidney stones in univariate and multivariate logistic regression analyses...
2017: PloS One
keyword
keyword
2081
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"