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https://www.readbyqxmd.com/read/29331715/toxicokinetics-of-zn-and-cd-in-the-earthworm-eisenia-andrei-exposed-to-metal-contaminated-soils-under-different-combinations-of-air-temperature-and-soil-moisture-content
#1
M Nazaret González-Alcaraz, Susana Loureiro, Cornelis A M van Gestel
This study evaluated how different combinations of air temperature (20 °C and 25 °C) and soil moisture content (50% and 30% of the soil water holding capacity, WHC), reflecting realistic climate change scenarios, affect the bioaccumulation kinetics of Zn and Cd in the earthworm Eisenia andrei. Earthworms were exposed for 21 d to two metal-contaminated soils (uptake phase), followed by 21 d incubation in non-contaminated soil (elimination phase). Body Zn and Cd concentrations were checked in time and metal uptake (k1) and elimination (k2) rate constants determined; metal bioaccumulation factor (BAF) was calculated as k1/k2...
January 8, 2018: Chemosphere
https://www.readbyqxmd.com/read/29323272/dominant-negative-smarca4-mutants-alter-the-accessibility-landscape-of-tissue-unrestricted-enhancers
#2
H Courtney Hodges, Benjamin Z Stanton, Katerina Cermakova, Chiung-Ying Chang, Erik L Miller, Jacob G Kirkland, Wai Lim Ku, Vaclav Veverka, Keji Zhao, Gerald R Crabtree
Mutation of SMARCA4 (BRG1), the ATPase of BAF (mSWI/SNF) and PBAF complexes, contributes to a range of malignancies and neurologic disorders. Unfortunately, the effects of SMARCA4 missense mutations have remained uncertain. Here we show that SMARCA4 cancer missense mutations target conserved ATPase surfaces and disrupt the mechanochemical cycle of remodeling. We find that heterozygous expression of mutants alters the open chromatin landscape at thousands of sites across the genome. Loss of DNA accessibility does not directly overlap with Polycomb accumulation, but is enriched in 'A compartments' at active enhancers, which lose H3K27ac but not H3K4me1...
January 2018: Nature Structural & Molecular Biology
https://www.readbyqxmd.com/read/29315779/trophic-transfer-of-cadmium-from-duckweed-lemna-minor-l-to-tilapia-oreochromis-mossambicus
#3
Yan Xue, Willie J G M Peijnenburg, Jin Huang, Dengjun Wang, Yan Jin
The transfer of the toxic heavy metal Cd from duckweed (Lemna minor L.) to the freshwater fish tilapia (Oreochromis mossambicus) was investigated. Concentrations of Cd in different chemical forms in duckweed and in different tissues (gut, edible muscle, and remnants) of tilapia, i.e., ethanol-extractable (FE ), HCl-extractable (FHCl ), and residual fractions (FR ) were quantified, and the bioaccumulation factors (BAF) of Cd in the tilapia body were calculated. Simple linear regression analysis was used to unravel the correlation and accumulation mechanisms of Cd along the short food chain...
January 5, 2018: Environmental Toxicology and Chemistry
https://www.readbyqxmd.com/read/29313217/temporal-pattern-and-crosstalk-of-necroptosis-markers-with-autophagy-and-apoptosis-associated-proteins-in-ischemic-hippocampus
#4
Fari Ryan, Fariba Khodagholi, Leila Dargahi, Dariush Minai-Tehrani, Abolhassan Ahmadiani
Necroptosis, a novel type of programmed cell death, has been recently implicated as a possible mechanism for cerebral ischemia-reperfusion (I/R) injury. We herein studied time-dependent changes of necroptosis markers along with apoptosis- and autophagy-associated proteins in rat hippocampus at 1, 3, 6, 12, 24, and 48 h after global cerebral I/R injury. Furthermore, to determine the cross talk between autophagy and necroptosis, we examined the effects of pretreatment with bafilomycin-A1 (Baf-A1), as a late-stage autophagy inhibitor, on necroptosis...
January 8, 2018: Neurotoxicity Research
https://www.readbyqxmd.com/read/29300412/the-influence-of-chemical-degradation-during-dietary-exposures-to-fish-on-biomagnification-factors-and-bioaccumulation-factors
#5
Jon A Arnot, Donald Mackay
The chemical dietary absorption efficiency (ED) quantifies the amount of chemical absorbed by an organism relative to the amount of chemical an organism is exposed to following ingestion. In particular, ED can influence the extent of bioaccumulation and biomagnification for hydrophobic chemicals. A new ED model is developed to quantify chemical process rates in the gastrointestinal tract (GIT). The new model is calibrated with critically evaluated measured ED values (n = 250) for 80 hydrophobic persistent chemicals...
January 4, 2018: Environmental Science. Processes & Impacts
https://www.readbyqxmd.com/read/29281090/novel-reagents-for-human-prolactin-research-large-scale-preparation-and-characterization-of-prolactin-receptor-extracellular-domain-non-pegylated-and-pegylated-prolactin-and-prolactin-receptor-antagonist
#6
Ewa Oclon, Gili Solomon, Zvi Hayouka, Tomer Meir Salame, Vincent Goffin, Arieh Gertler
To provide new tools for in vitro and in vivo prolactin (PRL) research, novel protocols for large-scale preparation of untagged human PRL (hPRL), a hPRL antagonist (del 1-9-G129R hPRL) that acts as a pure antagonist of hPRL in binding to hPRL receptor extracellular domain (hPRLR-ECD), and hPRLR-ECD are demonstrated. The interaction of del 1-9-G129R hPRL with hPRLR-ECD was demonstrated by competitive non-radioactive binding assay using biotinylated hPRL as the ligand and hPRLR-ECD as the receptor, by formation of stable 1:1 complexes with hPRLR-ECD under non-denaturing conditions using size-exclusion chromatography, and by surface plasmon resonance methodology...
December 21, 2017: Protein Engineering, Design & Selection: PEDS
https://www.readbyqxmd.com/read/29273567/1-hydroxy-3-e-4-piperazine-diium-but-2-enyloxy-9-10-anthraquinone-ditrifluoroactate-induced-autophagic-cell-death-in-human-pc3-cells
#7
A-Mei Huang, Kai-Wei Lin, Wei-Hong Lin, Li-Hung Wu, Hao-Chun Chang, Chujun Ni, Danny Ling Wang, Hsue-Yin Hsu, Chun-Li Su, Chiaho Shih
The autophagy of human prostate cancer cells (PC3 cells) induced by a new anthraquinone derivative, 1-Hydroxy-3-[(E)-4-(piperazine-diium)but-2-enyloxy]-9,10-anthraquinone ditrifluoroactate (PA) was investigated, and the relationship between autophagy and reactive oxygen species (ROS) generation was studied. The results indicated that PA induced PC3 cell death in a time- and dose-dependent manner, could inhibit PC3 cell growth by G1 phase cell cycle arrest and corresponding decrease in the G2/M cell population and induced S-phase arrest accompanied by a significant decrease G2/M and G1 phase numbers after PC3 cells treated with PA for 48 h, and increased the accumulation of autophagolysosomes and microtubule-associated protein LC3-ll, a marker of autophagy...
December 19, 2017: Chemico-biological Interactions
https://www.readbyqxmd.com/read/29247770/apigenin-promotes-trail-mediated-apoptosis-regardless-of-ros-generation
#8
Chang-Hee Kang, Ilandarage Menu Neelaka Molagoda, Yung Hyun Choi, Cheol Park, Dong-Oh Moon, Gi-Young Kim
Apigenin is a bioactive flavone in several herbs including parsley, thyme, and peppermint. Apigenin possesses anti-cancer and anti-inflammatory properties; however, whether apigenin enhances TRAIL-mediated apoptosis in cancer cells is unknown. In the current study, we found that apigenin enhanced TRAIL-induced apoptosis by promoting caspase activation and death receptor 5 (DR5) expression and a chimeric antibody against DR5 completely blocked the apoptosis. Apigenin also upregulated reactive oxygen species (ROS) generation; however, intriguingly, ROS inhibitors, glutathione (GSH) or N-acetyl-l-cysteine (NAC), moderately increased apigenin/TRAIL-induced apoptosis...
December 13, 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/29208974/bioaccumulation-of-pharmaceuticals-and-personal-care-product-chemicals-in-fish-exposed-to-wastewater-effluent-in-an-urban-wetland
#9
Derek Muir, Denina Simmons, Xiaowa Wang, Tom Peart, Maria Villella, Jason Miller, Jim Sherry
The bioaccumulation of a broad range of pharmaceuticals and personal care product chemicals (PPCPs) was studied in Cootes Paradise Marsh (CPM), an urban wetland that receives tertiary treated municipal waste waters as well as urban storm runoff. We measured PPCPs in caged and wild goldfish, as well as wild carp, and compared observed bioaccumulation factors (BAFP) using concentrations in surface waters and fish blood plasma, with modeled BAFs. Thirty-two PPCPs were detected in water from the central CPM site (CPM3) while 64 PPCPs were found at higher concentrations at a site immediately downstream of the effluent outflow (CPM1)...
December 5, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29197284/detection-of-ppcps-in-marine-organisms-from-contaminated-coastal-waters-of-the-saudi-red-sea
#10
Aasim M Ali, Helene Thorsen Rønning, Leiv K Sydnes, Walied M Alarif, Roland Kallenborn, Sultan S Al-Lihaibi
The occurrence of PPCPs in macroalgae, barnacle and fish samples from contaminated coastal waters of the Saudi Red Sea is reported. Solvent extraction followed by solid phase extraction was applied to isolate the compounds, and their quantification was carried out by high performance liquid chromatography-tandem mass spectrometry. Atenolol, ranitidine, chlorpheniramine, DEET, and atrazine were detected in one or more macroalgae at <LOQ concentration, whereas caffeine, methylparaben, and carbamazepine were present atmaximum concentrations of 41...
November 29, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29190594/correlating-microbial-community-structure-with-operational-conditions-in-biological-aerated-filter-reactor-for-efficient-nitrogen-removal-of-municipal-wastewater
#11
Bo Yang, Jinzhao Wang, Junfeng Wang, Hui Xu, Xinshan Song, Yuhui Wang, Fang Li, Yanbiao Liu, Junhong Bai
In this study, the combination of strengthen circulation anaerobic (SCA) and biological aerated filter (BAF) reactor was employed to treat municipal wastewater. Different reflux percentages or gas/water ratios were selected for evaluating the removal performance of contaminants in SCA-BAF system and sequential nitrification and denitrification process in BAF reactor. In general, reflux percentage (200%) and gas/water ratio (3:1) were a relatively suitable operational condition for BAF reactor. The COD, NH3-N, TN concentrations of effluents collected from BAF reactor varied in the ranges of 18-80, 0...
November 23, 2017: Bioresource Technology
https://www.readbyqxmd.com/read/29189191/edible-mushrooms-from-niger-delta-nigeria-with-heavy-metal-levels-of-public-health-concern-a-human-health-risk-assessment
#12
Sorbari Igbiri, Nnaemeka Arinze Udowelle, Osazuwa Clinton Ekhator, Rose Ngozi Asomugha, Zelinjo Nkeiruka Igweze, Orish Ebere Orisakwe
Edible mushrooms are highly nutritious with vast pharmacological/medicinal properties. This study has determined the potential human health risk associated with the consumption of mushroom in Niger Delta, Nigeria. Concentrations of Pb, Cd, Sn, Cu, Ni, Al and Zn in both wild/cultivated mushroom and background soil/substrate were determined using Atomic Absorption Spectrometer (AAS). Heavy metal pollution was calculated using bioaccumulation factor (BAF) and pollution load index (PLI) while human health risk assessment employed estimated daily intake (EDI), target hazard quotient (THQ), hazard index (HI), carcinogenic risk (CR) and total cancer risk (TCR)...
November 29, 2017: Recent Patents on Food, Nutrition & Agriculture
https://www.readbyqxmd.com/read/29188441/vulnerability-of-canadian-aquatic-ecosystems-to-nuclear-accidents
#13
Lars Brinkmann, David J Rowan
Several cesium and strontium bioaccumulation models are used widely in national and international guidance for ecological and human health risk assessments for radiocesium (134Cs and 137Cs) and radiostrontium (90Sr), but have not been used to make predictions of radiological risk from nuclear accidents under variable environmental conditions on broad geographical scales. In this paper, we first present models for predicting the bioaccumulation of cesium and strontium by aquatic biota based on ambient concentrations of dissolved potassium and calcium, respectively, and then test these models using independent data from aquatic ecosystems at Canadian nuclear sites...
November 29, 2017: Ambio
https://www.readbyqxmd.com/read/29187968/the-xeric-side-of-the-brazilian-atlantic-forest-the-forces-shaping-phylogeographic-structure-of-cacti
#14
Fernando Faria Franco, Cecília Leiko Jojima, Manolo Fernandez Perez, Daniela Cristina Zappi, Nigel Taylor, Evandro Marsola Moraes
In order to investigate biogeographic influences on xeric biota in the Brazilian Atlantic Forest (BAF), a biodiversity hotspot, we used a monophyletic group including three cactus taxa as a model to perform a phylogeographic study: Cereus fernambucensis subsp. fernambucensis, C. fernambucensis subsp. sericifer, and C. insularis. These cacti are allopatric and grow in xeric habitats along BAF, including isolated granite and gneiss rock outcrops (Inselbergs), sand dune vegetation (Restinga forest), and the rocky shore of an oceanic archipelago (islands of Fernando de Noronha)...
November 2017: Ecology and Evolution
https://www.readbyqxmd.com/read/29183906/cardiac-enriched-baf-chromatin-remodeling-complex-subunit-baf60c-regulates-gene-expression-programs-essential-for-heart-development-and-function
#15
Xin Sun, Swetansu K Hota, Yu-Qing Zhou, Stefanie Novak, Dario Miguel-Perez, Danos Christodoulou, Christine E Seidman, J G Seidman, Carol C Gregorio, R Mark Henkelman, Janet Rossant, Benoit G Bruneau
How chromatin-remodeling complexes modulate gene networks to control organ-specific properties is not well understood. For example, Baf60c (Smarcd3) encodes a cardiac-enriched subunit of the SWI/SNF-like BAF chromatin complex, but its role in heart development is not fully understood. We found that constitutive loss of Baf60c leads to embryonic cardiac hypoplasia and pronounced cardiac dysfunction. Conditional deletion of Baf60c in cardiomyocytes resulted in postnatal dilated cardiomyopathy with impaired contractile function...
November 28, 2017: Biology Open
https://www.readbyqxmd.com/read/29176924/novel-phonotactic-learning-tracking-syllable-position-and-co-occurrence-constraints
#16
Amélie Bernard
Are syllable-level and co-occurrence representations simultaneously available when one learns novel phonotactics? After training on word-medial consonant restrictions (e.g., word-medial onsets P/Z, codas D/F, and cross-syllable consonant clusters FP/DZ in items like baF.Pev, tiD.Zek), adults falsely recognized novel items containing restricted consonants with the same co-occurrences (e.g., FP) more often than those with different co-occurrences (e.g., FZ) when syllable-position information was kept constant (e...
October 2017: Journal of Memory and Language
https://www.readbyqxmd.com/read/29156303/assessment-of-nickel-bioavailability-through-chemical-extractants-and-red-clover-trifolium-pratense-l-in-an-amended-soil-related-changes-in-various-parameters-of-red-clover
#17
Ali Khan Shahbaz, Muhammad Iqbal, Abdul Jabbar, Sabir Hussain, Muhammad Ibrahim
Application of immobilizing agents may efficiently reduce the bioavailability of nickel (Ni) in the soil. Here we report the effect of biochar (BC), gravel sludge (GS) and zeolite (ZE) as a sole treatment and their combinations on the bioavailability of Ni after their application into a Ni-polluted soil. The bioavailability of Ni after the application of immobilizing agents was assessed through an indicator plant (red clover) and chemical indicators of bioavailability like soil water extract (SWE), DTPA and Ca(NO3)2 extracts...
November 17, 2017: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/29144431/bioabsorption-and-bioaccumulation-of-cadmium-in-the-straw-and-grain-of-maize-zea-mays-l-in-growing-soils-contaminated-with-cadmium-in-different-environment
#18
Jorge Retamal-Salgado, Juan Hirzel, Ingrid Walter, Iván Matus
There is a worldwide increase of heavy metal or potentially toxic element (PTE), contamination in agricultural soils caused mainly by human and industrial action, which leads to food contamination in crops such as in maize. Cadmium (Cd) is a PTE often found in soils and it is ingested through food. It is necessary to determine the bioabsorption, distribution, and accumulation levels in maize to reduce or prevent food chain contamination. Cadmium absorption and accumulation in three maize cultivars were evaluated in three agricultural environments in Chile by increasing CdCl₂ rates (0, 1, and 2 mg·kg(-1))...
November 16, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29138773/cooperating-dipole-dipole-and-van-der-waals-interactions-driven-2d-self-assembly-of-fluorenone-derivatives-ester-chain-length-effect
#19
Meiqiu Dong, Kai Miao, Yi Hu, Juntian Wu, Jinxing Li, Peng Pang, Xinrui Miao, Wenli Deng
Two-dimensional supramolecular assemblies of a series of 2,7-bis(10-n-alkoxycarbonyl-decyloxy)-9-fluorenone derivatives (BAF-Cn, n = 1, 3-6) consisting of polar fluorenone moieties and ester alkoxy chains were investigated by scanning tunneling microscopy on highly oriented pyrolytic graphite surfaces. The chain-length effect was observed in the self-assembly of BAF-Cn. Self-assembly of BAF-C1 was composed of a linear I pattern, where the side chains adopted a fully interdigitated arrangement. As the length of side chains increased, the coexistence of a linear I pattern and a cyclic pattern for the self-assembly of BAF-C3 was observed...
November 15, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/29136498/a-two-faced-mswi-snf-subunit-dual-roles-for-arid1a-in-tumor-suppression-and-oncogenicity-in-the-liver
#20
Jordan E Otto, Cigall Kadoch
In this issue of Cancer Cell, Sun et al. describe context-dependent oncogenic and tumor-suppressive functions for the mammalian SWI/SNF (BAF) complex subunit ARID1A in the development and progression of hepatocellular carcinoma (HCC).
November 13, 2017: Cancer Cell
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