keyword
https://read.qxmd.com/read/38485766/lamin-b1-curtails-early-human-papillomavirus-infection-by-safeguarding-nuclear-compartmentalization-and-autophagic-capacity
#1
JOURNAL ARTICLE
Freya Molenberghs, Marlies Verschuuren, Lauran Vandeweyer, Sarah Peeters, Johannes J Bogers, Claudina Perez Novo, Wim Vanden Berghe, Hans De Reu, Nathalie Cools, Mario Schelhaas, Winnok H De Vos
Human papillomavirus (HPV) infection is a primary cause of cervical and head-and-neck cancers. The HPV genome enters the nucleus during mitosis when the nuclear envelope disassembles. Given that lamins maintain nuclear integrity during interphase, we asked to what extent their loss would affect early HPV infection. To address this question, we infected human cervical cancer cells and keratinocytes lacking the major lamins with a HPV16 pseudovirus (HP-PsV) encoding an EGFP reporter. We found that a sustained reduction or complete loss of lamin B1 significantly increased HP-PsV infection rate...
March 14, 2024: Cellular and Molecular Life Sciences: CMLS
https://read.qxmd.com/read/38482414/-hes1-induces-itpr1-mediated-autophagy-to-exert-anti-metastatic-effects-in-pituitary-adenomas
#2
JOURNAL ARTICLE
Chunjian Qiu, Yao Yao, Suqin Hu, Yixin Xu
BACKGROUND: Pituitary adenomas (PAs) are prevalent intracranial tumors necessitating a comprehensive exploration of their molecular intricacies. This study delved into the molecular interactions among HES1 (hairy and enhancer of split 1), ITPR1 (inositol 1,4,5-trisphosphate receptor, type 1), and autophagy to elucidate their contributions to PA progression. METHODS: Our in-depth bioinformatics analysis identified ITPR1 as a central hub gene in the PA-associated dataset...
February 29, 2024: Translational Cancer Research
https://read.qxmd.com/read/38472198/identifying-regulators-of-aberrant-stem-cell-and-differentiation-activity-in-colorectal-cancer-using-a-dual-endogenous-reporter-system
#3
JOURNAL ARTICLE
Sandor Spisak, David Chen, Pornlada Likasitwatanakul, Paul Doan, Zhixin Li, Pratyusha Bala, Laura Vizkeleti, Viktoria Tisza, Pushpamali De Silva, Marios Giannakis, Brian Wolpin, Jun Qi, Nilay S Sethi
Aberrant stem cell-like activity and impaired differentiation are central to the development of colorectal cancer (CRC). To identify functional mediators of these key cellular programs, we engineer a dual endogenous reporter system by genome-editing the SOX9 and KRT20 loci of human CRC cell lines to express fluorescent reporters, broadcasting aberrant stem cell-like and differentiation activity, respectively. By applying a CRISPR screen targeting 78 epigenetic regulators with 542 sgRNAs to this platform, we identify factors that contribute to stem cell-like activity and differentiation in CRC...
March 12, 2024: Nature Communications
https://read.qxmd.com/read/38460559/achieving-advanced-nitrogen-removal-from-mature-landfill-leachate-in-continuous-flow-system-involving-partial-nitrification-anammox-and-denitrification
#4
JOURNAL ARTICLE
Lina Wu, Yulin Zhang, Jian Yin, Anteng Luo, Yinghao Tian, Yufan Liu, Jiayuan Xu, Yongzhen Peng
Considering the challenges associated with nitrogen removal from mature landfill leachate, a novel combined continuous-flow process integrating denitrification and partial nitrification-Anammox (PN/A) was developed using an internal circulation (IC) system and a biological aerated filter (BAF) biofilm reactor (IBBR). In this study, IBBR successfully operated for 343 days, and when influent NH4 + -N concentration of mature landfill leachate reached 1258.1 mg/L, an impressive total nitrogen removal efficiency (TNRE) of 93...
March 7, 2024: Bioresource Technology
https://read.qxmd.com/read/38458188/smarca4-is-a-haploinsufficient-b-cell-lymphoma-tumor-suppressor-that-fine-tunes-centrocyte-cell-fate-decisions
#5
JOURNAL ARTICLE
Qing Deng, Priya Lakra, Panhong Gou, Haopeng Yang, Cem Meydan, Matthew Teater, Christopher Chin, Wenchao Zhang, Tommy Dinh, Usama Hussein, Xubin Li, Estela Rojas, Weiguang Liu, Patrick K Reville, Atish Kizhakeyil, Darko Barisic, Sydney Parsons, Ashley Wilson, Jared Henderson, Brooks Scull, Channabasavaiah Gurumurthy, Francisco Vega, Amy Chadburn, Branko Cuglievan, Nader Kim El-Mallawany, Carl Allen, Christopher Mason, Ari Melnick, Michael R Green
SMARCA4 encodes one of two mutually exclusive ATPase subunits in the BRG/BRM associated factor (BAF) complex that is recruited by transcription factors (TFs) to drive chromatin accessibility and transcriptional activation. SMARCA4 is among the most recurrently mutated genes in human cancer, including ∼30% of germinal center (GC)-derived Burkitt lymphomas. In mice, GC-specific Smarca4 haploinsufficiency cooperated with MYC over-expression to drive lymphomagenesis. Furthermore, monoallelic Smarca4 deletion drove GC hyperplasia with centroblast polarization via significantly increased rates of centrocyte recycling to the dark zone...
March 1, 2024: Cancer Cell
https://read.qxmd.com/read/38458187/arid1a-orchestrates-swi-snf-mediated-sequential-binding-of-transcription-factors-with-arid1a-loss-driving-pre-memory-b-cell-fate-and-lymphomagenesis
#6
JOURNAL ARTICLE
Darko Barisic, Christopher R Chin, Cem Meydan, Matt Teater, Ioanna Tsialta, Coraline Mlynarczyk, Amy Chadburn, Xuehai Wang, Margot Sarkozy, Min Xia, Sandra E Carson, Santo Raggiri, Sonia Debek, Benedikt Pelzer, Ceyda Durmaz, Qing Deng, Priya Lakra, Martin Rivas, Christian Steidl, David W Scott, Andrew P Weng, Christopher E Mason, Michael R Green, Ari Melnick
ARID1A, a subunit of the canonical BAF nucleosome remodeling complex, is commonly mutated in lymphomas. We show that ARID1A orchestrates B cell fate during the germinal center (GC) response, facilitating cooperative and sequential binding of PU.1 and NF-kB at crucial genes for cytokine and CD40 signaling. The absence of ARID1A tilts GC cell fate toward immature IgM+ CD80- PD-L2- memory B cells, known for their potential to re-enter new GCs. When combined with BCL2 oncogene, ARID1A haploinsufficiency hastens the progression of aggressive follicular lymphomas (FLs) in mice...
March 4, 2024: Cancer Cell
https://read.qxmd.com/read/38455530/health-risk-assessment-of-heavy-metals-in-saffron-crocus-sativus-l-cultivated-in-domestic-wastewater-and-lake-water-irrigated-soils
#7
JOURNAL ARTICLE
Sami Abou Fayssal, Pankaj Kumar, Simona M Popescu, Mehraj Ud-Din Khanday, Hasan Sardar, Riaz Ahmad, Deep Gupta, Sudhir Kumar Gaur, Hesham F Alharby, Abdullah G Al-Ghamdi
Irrigation of crops with domestic wastewater (DW) is a common practice in developing countries like India. However, domestic wastewater irrigation poses a risk of migration of toxic heavy metals to edible parts of crops, which requires serious measures to prevent their uptake. In this study, the effect of DW irrigation in comparison with Sarbal Lake water (SLW) and borewell water (BW) on soil characteristics and cultivated saffron ( Crocus sativus L.) was investigated. For this purpose, samples of water, soil, and saffron (corm, petal, and stigma) were collected from the suburban area of Pampore, Srinagar district, Jammu and Kashmir, India...
March 15, 2024: Heliyon
https://read.qxmd.com/read/38437498/brg1-brm-inhibitor-targets-aml-stem-cells-and-exerts-superior-preclinical-efficacy-combined-with-bet-or-menin-inhibitor
#8
JOURNAL ARTICLE
Warren Fiskus, Jessica Piel, Michael P Collins, Murphy Hentemann, Branko Cuglievan, Christopher P Mill, Christine Birdwell, Kaberi Das, John A Davis, Hanxi Hou, Antrix Jain, Anna Malovannaya, Tapan M Kadia, Naval G Daver, Koji Sasaki, Koichi Takahashi, Danielle Hammond, Patrick K Reville, Jian Wang, Sanam Loghavi, Rwik Sen, Xinjia Ruan, Xiaoping Su, Lauren Flores, Courtney D DiNardo, Kapil N Bhalla
BRG1 (SMARCA4) and BRM (SMARCA2) are the mutually exclusive core ATPases of the chromatin remodeling BAF (BRG1/BRM-associated factor) complexes. They enable transcription factors/co-factors to access enhancers/promoter and modulate gene-expressions responsible for cell growth and differentiation of AML stem/progenitor cells. In AML with MLL1r (MLL1 rearrangement) or mutant (mt) NPM1, although Menin inhibitor (MI) treatment induces clinical remissions, most patients either fail to respond or relapse, some harboring Menin mutations...
February 16, 2024: Blood
https://read.qxmd.com/read/38432362/responses-and-resistance-capacity-of-solanum-nigrum-l-mediated-by-three-ecological-category-earthworms-in-metal-cd-as-cu-pb-contaminated-soils-of-north-china
#9
JOURNAL ARTICLE
Xiaoquan Mu, Bo Li, Wenju Liu, Yuhui Qiao, Caide Huang, Yang Yang, Menghan Zhang, Xinru Wang, Yanan Liu, Yin Yue, Kun Wang
Earthworms play vital functions affecting plant growth and metal accumulation from downground to aboveground. Soil metal mobilization may be combined with use of earthworm and hyperaccumulator-Solanum nigrum to improve its remediation efficiency. Understanding the effects of specific-species earthworm belonging to different ecological categories on mechanisms underlying of S. nigrum is critical for metal-polluted remediation. However, seldom studies concerned earthworm-assisted phytoremediation of metal contaminated soil in Northern China...
March 1, 2024: Science of the Total Environment
https://read.qxmd.com/read/38427725/brg1-establishes-the-neuroectodermal-chromatin-landscape-to-restrict-dorsal-cell-fates
#10
JOURNAL ARTICLE
Jackson A Hoffman, Ginger W Muse, Lee F Langer, A Isabella Patterson, Isabella Gandara, James M Ward, Trevor K Archer
Cell fate decisions are achieved with gene expression changes driven by lineage-specific transcription factors (TFs). These TFs depend on chromatin remodelers including the Brahma-related gene 1 (BRG1)-associated factor (BAF) complex to activate target genes. BAF complex subunits are essential for development and frequently mutated in cancer. Thus, interrogating how BAF complexes contribute to cell fate decisions is critical for human health. We examined the requirement for the catalytic BAF subunit BRG1 in neural progenitor cell (NPC) specification from human embryonic stem cells...
March 2024: Science Advances
https://read.qxmd.com/read/38427563/swi-snf-dependent-genes-are-defined-by-their-chromatin-landscape
#11
JOURNAL ARTICLE
Laura Basurto-Cayuela, José A Guerrero-Martínez, Elena Gómez-Marín, Elena Sánchez-Escabias, María Escaño-Maestre, María Ceballos-Chávez, José C Reyes
SWI/SNF complexes are evolutionarily conserved, ATP-dependent chromatin remodeling machines. Here, we characterize the features of SWI/SNF-dependent genes using BRM014, an inhibitor of the ATPase activity of the complexes. We find that SWI/SNF activity is required to maintain chromatin accessibility and nucleosome occupancy for most enhancers but not for most promoters. SWI/SNF activity is needed for expression of genes with low to medium levels of expression that have promoters with (1) low chromatin accessibility, (2) low levels of active histone marks, (3) high H3K4me1/H3K4me3 ratio, (4) low nucleosomal phasing, and (5) enrichment in TATA-box motifs...
February 29, 2024: Cell Reports
https://read.qxmd.com/read/38426308/pilot-study-assessing-the-safety-and-acceptance-of-a-novel-virtual-reality-system-to-improve-visual-function
#12
JOURNAL ARTICLE
David P Piñero, Luis Leal-Vega, Ainhoa Molina-Martín, Carlos J Hernández-Rodríguez, Rubén Cuadrado-Asensio, Adrián Martín-Gutiérrez, Juan Francisco Arenillas Lara, María Begoña Coco Martín
PURPOSE: To assess the feasibility of the clinical use of a novel Virtual Reality (VR) training software designed to be used for active vision therapy in amblyopic patients by determining its preliminary safety and acceptance on the visual function of healthy adults. METHODS: Pilot study enrolling 10 individuals (3 men, 7 women, mean age: 31.8 ± 6.5 years) with a best-corrected visual acuity (BCVA) of ≥ .90 (decimal) in both eyes were evaluated before and after 20 minutes of exposure to the NEIVATECH VR system using the HTC Vive Pro Eye head mounted display...
March 1, 2024: Seminars in Ophthalmology
https://read.qxmd.com/read/38423320/impact-of-harmful-algal-bloom-severity-on-bacterial-communities-in-a-full-scale-biological-filtration-system-for-drinking-water-treatment
#13
JOURNAL ARTICLE
Youchul Jeon, Lei Li, Mudit Bhatia, Hodon Ryu, Jorge W Santo Domingo, Jess Brown, Jake Goetz, Youngwoo Seo
The occurrence of harmful algal blooms (HABs) in freshwater environments has been expanded worldwide with growing frequency and severity. HABs can pose a threat to public water supplies, raising concerns about safety of treated water. Many studies have provided valuable information about the impacts of HABs and management strategies on the early-stage treatment processes (e.g., pre-oxidation and coagulation/flocculation) in conventional drinking water treatment plants (DWTPs). However, the potential effect of HAB-impacted water in the granular media filtration has not been well studied...
February 27, 2024: Science of the Total Environment
https://read.qxmd.com/read/38417525/site-and-species-specific-metal-concentrations-mobility-and-bioavailability-in-sediment-flora-and-fauna-of-a-southeastern-united-states-salt-marsh
#14
JOURNAL ARTICLE
Sarah E Donaher, Shanna L Estes, Robert P Dunn, Annelise K Gonzales, Brian A Powell, Nicole E Martinez
Salt marshes are highly productive and valuable coastal ecosystems that act as filters for nutrients and pollutants at the land-sea interface. The salt marshes of the mid-Atlantic United States often exhibit geochemical behavior that varies significantly from other estuaries around the world, but our understanding of metal mobility and bioavailability remains incomplete for these systems. We sampled abiotic (water and sediment) and native biotic (three halophyte and two bivalve species) compartments of a southeastern United States salt marsh to understand the site- and species-specific metal concentrations, fractionation, and bioavailability for 16 metals and metalloids, including two naturally occurring radionuclides...
February 26, 2024: Science of the Total Environment
https://read.qxmd.com/read/38406272/heavy-metal-movement-through-insect-food-chains-in-pristine-thermal-springs-of-yellowstone-national-park
#15
JOURNAL ARTICLE
Braymond Adams, John Bowley, Monica Rohwer, Erik Oberg, Kelly Willemssens, Wendy Wintersteen, Robert K D Peterson, Leon G Higley
Yellowstone National Park thermal features regularly discharge various heavy metals and metalloids. These metals are taken up by microorganisms that often form mats in thermal springs. These microbial mats also serve as food sources for invertebrate assemblages. To examine how heavy metals move through insect food webs associated with hot springs, two sites were selected for this study. Dragon-Beowulf Hot Springs, acid-sulfate chloride springs, have a pH of 2.9, water temperatures above 70 °C, and populations of thermophilic bacterial, archaeal, and algal mats...
2024: PeerJ
https://read.qxmd.com/read/38393247/removal-of-chromium-iii-and-reduction-in-toxicity-in-a-primary-tannery-effluent-using-two-floating-macrophytes
#16
JOURNAL ARTICLE
Tomás R López Arias, Deidamia Franco, Leonida Medina, César Benítez, Verónica Villagra, Shaun McGahan, Giselle Mariza Duré, Hajime G Kurita-Oyamada
Trivalent chromium (Cr(III)) is a contaminant with toxic activity. Its presence in waters and soils is usually related to industrial activities such as tanneries. The aim of this study was to compare the removal of Cr(III) in hydroponic solutions and tannery effluents using two floating macrophytes: Salvinia auriculata and Eichhornia crassipes . First, to determine the chromium removal capacity in solution and the bioaccumulation factor (BAF) in tissues of each plant, experiments were set up with contaminated solutions with Cr(III) concentrations of 2, 5, 10, 20, and 40 mg/L...
February 16, 2024: Toxics
https://read.qxmd.com/read/38382184/fate-and-effects-of-a-new-generation-fluorosurfactant-cc-6-o-4-in-freshwater-mesocosms
#17
JOURNAL ARTICLE
Andreu Rico, Melina Crettaz-Minaglia, Ariadna García-Astillero, Elisa Bizzotto, Marco Vighi
Per- and polyfluorinated alkyl substances (PFAS) have raised international concerns due to their widespread use, environmental persistence and potential bioaccumulative and ecotoxicological effects. Therefore, the chemical industry has been dedicated to develop new generation fluorosurfactants which are aimed to replace the most concerning PFAS. Here we investigated the fate and effects of cyclic C6 O4 (cC6 O4 ), a compound used as alternative to long-chain perfluorocarboxylic acids, in freshwater mesocosms located in the Mediterranean region (Spain) over a period of 90 days...
February 18, 2024: Aquatic Toxicology
https://read.qxmd.com/read/38377757/a-novel-physical-biochemical-treatment-of-refinery-wastewater
#18
JOURNAL ARTICLE
Yong Gu, Pinyi Dai, Tao Wu, Fang Yuan, Qiang Yang
As of 2022, China has achieved a crude oil processing capacity of 918 million tons, leading to a notable escalation in the production of refinery wastewater. The composition of refinery wastewater is intricate and diverse, posing a substantial challenge to its treatment. In order to facilitate appropriate discharge or reuse, an exhaustive separation process is imperative for refinery wastewater. Conventional pre-treatment processes typically employ inclined plate separators and dissolved air flotation (DAF) for the removal of oil and suspended solids (SS), while sequencing batch reactor (SBR), oxidation ditch, or biological aerated filter (BAF) are employed for the biological treatment process...
February 19, 2024: Journal of Environmental Management
https://read.qxmd.com/read/38374207/baf-mediated-transcriptional-regulation-of-teashirt-is-essential-for-the-development-of-neural-progenitor-cell-lineages
#19
JOURNAL ARTICLE
Byung Su Ko, Myeong Hoon Han, Min Jee Kwon, Dong Gon Cha, Yuri Ji, Eun Seo Park, Min Jae Jeon, Somi Kim, Kyeongho Lee, Yoon Ha Choi, Jusung Lee, Monica Torras-Llort, Ki-Jun Yoon, Hyosang Lee, Jong Kyoung Kim, Sung Bae Lee
Accumulating evidence hints heterochromatin anchoring to the inner nuclear membrane as an upstream regulatory process of gene expression. Given that the formation of neural progenitor cell lineages and the subsequent maintenance of postmitotic neuronal cell identity critically rely on transcriptional regulation, it seems possible that the development of neuronal cells is influenced by cell type-specific and/or context-dependent programmed regulation of heterochromatin anchoring. Here, we explored this possibility by genetically disrupting the evolutionarily conserved barrier-to-autointegration factor (Baf) in the Drosophila nervous system...
February 19, 2024: Experimental & Molecular Medicine
https://read.qxmd.com/read/38361405/autophagy-inhibitors-3-ma-and-baf-may-attenuate-hippocampal-neuronal-necroptosis-after-global-cerebral-ischemia-reperfusion-injury-in-male-rats-by-inhibiting-the-interaction-of-the-rip3-aif-cypa-complex
#20
JOURNAL ARTICLE
Chen Zhang, Renhui Liu, Mengmeng Chen, Yang Xu, Xiaoqin Jin, Bing Shen, Jingye Wang
Our previous study found that receptor interacting protein 3 (RIP3) and apoptosis-inducing factor (AIF) were involved in neuronal programmed necrosis during global cerebral ischemia-reperfusion (I/R) injury. Here, we further studied its downstream mechanisms and the role of the autophagy inhibitors 3-methyladenine (3-MA) and bafilomycin A1 (BAF). A 20-min global cerebral I/R injury model was constructed using the 4-vessel occlusion (4-VO) method in male rats. 3-MA and BAF were injected into the lateral ventricle 1 h before ischemia...
February 2024: Journal of Neuroscience Research
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