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https://www.readbyqxmd.com/read/28226247/biologically-active-filters-an-advanced-water-treatment-process-for-contaminants-of-emerging-concern
#1
Shuangyi Zhang, Stephen W Gitungo, Lisa Axe, Robert F Raczko, John E Dyksen
With the increasing concern of contaminants of emerging concern (CECs) in source water, this study examines the hypothesis that existing filters in water treatment plants can be converted to biologically active filters (BAFs) to treat these compounds. Removals through bench-scale BAFs were evaluated as a function of media, granular activated carbon (GAC) and dual media, empty bed contact time (EBCT), and pre-ozonation. For GAC BAFs, greater oxygen consumption, increased pH drop, and greater dissolved organic carbon removal normalized to adenosine triphosphate (ATP) were observed indicating increased microbial activity as compared to anthracite/sand dual media BAFs...
February 7, 2017: Water Research
https://www.readbyqxmd.com/read/28214847/contribution-of-p62-to-phenotype-transition-of-coronary-arterial-myocytes-with-defective-autophagy
#2
Junxiang Bao, Guangbi Li, Xinxu Yuan, Erich Gulbins, Pin-Lan Li
BACKGROUND: Autophagy disorder contributes to dedifferentiation of arterial smooth muscle cells, but the mechanisms are poorly understood. Here, we sought to investigate the role of scaffolding adaptor p62/SQSTM1 (p62) in phenotype switching of mouse coronary arterial myocytes (CAMs) induced by CD38 gene deficiency or lysosomal dysfunction which blocks autophagic flux in the cells. METHODS: Protein expression was measured by western blot analysis and immunofluorescent staining...
3, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/28212528/the-crispr-cas9%C3%A2-system-efficiently-reverts-the-tumorigenic-ability-of-bcr-abl-in-vitro-and-in-a-xenograft-model-of-chronic-myeloid-leukemia
#3
Ignacio García-Tuñón, María Hernández-Sánchez, José Luis Ordoñez, Veronica Alonso-Pérez, Miguel Álamo-Quijada, Rocio Benito, Carmen Guerrero, Jesús María Hernández-Rivas, Manuel Sánchez-Martín
CRISPR/Cas9 technology was used to abrogate p210 oncoprotein expression in the Boff-p210 cell line, a pro-B line derived from interlukin-3-dependent Baf/3, that shows IL-3-independence arising from the constitutive expression of BCR-ABL p210. Using this approach, pools of Boff-p210-edited cells and single edited cell-derived clones were obtained and functionally studied in vitro. The loss of p210 expression in Boff-p210 cells resulted in the loss of ability to grow in the absence of IL-3, as the Baf/3 parental line, showing significantly increased apoptosis levels...
February 9, 2017: Oncotarget
https://www.readbyqxmd.com/read/28197973/assessment-and-evaluation-of-an-integrated-hybrid-anaerobic-aerobic-sewage-treatment-system-for-the-removal-of-enteric-viruses
#4
Waled Morsy El-Senousy, Sohair Imam Abou-Elela
The capability of a cost-effective and a small size decentralized pilot wastewater treatment plant (WWTP) to remove enteric viruses such as rotavirus, norovirus genogroup I (GGI), norovirus genogroup II (GGII), Hepatitis E virus (HEV), and adenovirus was studied. This pilot plant is an integrated hybrid anaerobic/aerobic setup which consisted of anaerobic sludge blanket (UASB), biological aerated filter (BAF), and inclined plate settler (IPS). Both the UASB and BAF are packed with a non-woven polyester fabric (NWPF)...
February 14, 2017: Food and Environmental Virology
https://www.readbyqxmd.com/read/28194222/intelligibility-evaluation-of-pathological-speech-through-multigranularity-feature-extraction-and-optimization
#5
Chunying Fang, Haifeng Li, Lin Ma, Mancai Zhang
Pathological speech usually refers to speech distortion resulting from illness or other biological insults. The assessment of pathological speech plays an important role in assisting the experts, while automatic evaluation of speech intelligibility is difficult because it is usually nonstationary and mutational. In this paper, we carry out an independent innovation of feature extraction and reduction, and we describe a multigranularity combined feature scheme which is optimized by the hierarchical visual method...
2017: Computational and Mathematical Methods in Medicine
https://www.readbyqxmd.com/read/28193841/dual-roles-of-akirin2-during-xenopus-neural-development
#6
Xiaoliang Liu, Yingjie Xia, Jixin Tang, Li Ma, Chaocui Li, Pengcheng Ma, Bingyu Mao
To ensure correct spatial and temporal patterning, embryos must maintain pluripotent cell populations and control when cells undergo commitment. The newly identified nucleoprotein Akirin has been shown to modulate the innate immune response through epigenetic regulation and to play important roles in other physiological processes, but its role in neural development remains unknown. Here, we show that Akirin2 is required for neural development in Xenopus and knockdown of Akirin2 expands the expression of the neural progenitor marker Sox2 and inhibits expression of the differentiated neuronal marker N-tubulin...
February 13, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28192988/accumulation-of-perfluoroalkylated-substances-in-oceanic-plankton
#7
Paulo Casal, Belén González-Gaya, Yifeng Zhang, Anthony J F Reardon, Jonathan W Martin, Begoña Jiménez, Jordi Dachs
The bioaccumulation of perfluoroalkylated substances (PFASs) in plankton has previously been evaluated only in freshwater and regional seas, but not for the large oligotrophic global oceans. Plankton samples from the tropical and subtropical Pacific, Atlantic and Indian Oceans were collected during the Malaspina 2010 circumnavigation expedition, and analyzed for 14 ionizable PFASs, including perfluorooctanoate (PFOA), perfluorooctanesulfonate (PFOS) and their respective linear and branched isomers. PFOA and PFOS concentrations in plankton ranged from 0...
February 24, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28166918/the-concomitant-occurrence-of-pulmonary-tuberculosis-with-bronchial-anthracofibrosis
#8
Shekhar Kunal, Ashok Shah
BACKGROUND: Bronchial anthracofibrosis (BAF), diagnosed bronchoscopically, is a clinical entity which is now beginning to emerge from obscurity. This is commonly encountered in elderly females with history of long-standing exposure to biomass fuel smoke in poorly ventilated kitchens. As awareness of BAF has increased in recent times, distinct clinicoradiological and bronchoscopic features of the disease have emerged. Diagnosis is achieved by visualisation of bluish-black mucosal hyperpigmentation along with narrowing/distortion of the affected bronchus on fibreoptic bronchoscopy (FOB)...
January 2017: Indian Journal of Tuberculosis
https://www.readbyqxmd.com/read/28124119/heterozygosity-for-arid2-loss-of-function-mutations-in-individuals-with-a-coffin-siris-syndrome-like-phenotype
#9
Nuria C Bramswig, O Caluseriu, H-J Lüdecke, F V Bolduc, N C L Noel, T Wieland, H M Surowy, H-J Christen, H Engels, T M Strom, D Wieczorek
Chromatin remodeling is a complex process shaping the nucleosome landscape, thereby regulating the accessibility of transcription factors to regulatory regions of target genes and ultimately managing gene expression. The SWI/SNF (switch/sucrose nonfermentable) complex remodels the nucleosome landscape in an ATP-dependent manner and is divided into the two major subclasses Brahma-associated factor (BAF) and Polybromo Brahma-associated factor (PBAF) complex. Somatic mutations in subunits of the SWI/SNF complex have been associated with different cancers, while germline mutations have been associated with autism spectrum disorder and the neurodevelopmental disorders Coffin-Siris (CSS) and Nicolaides-Baraitser syndromes (NCBRS)...
January 25, 2017: Human Genetics
https://www.readbyqxmd.com/read/28120307/performance-of-the-biological-aerated-filter-bioaugmented-by-a-yeast-magnusiomyces-ingens-lh-f1-for-treatment-of-acid-red-b-and-microbial-community-dynamics
#10
Muyang He, Liang Tan, Shuxiang Ning, Li Song, Shengnan Shi
Biological aerated filters (BAFs) were constructed and operated for assessing the effectiveness of bacterial community bioaugmented by a yeast Magnusiomyces ingens LH-F1 for treatment of azo dye Acid Red B (ARB). Dynamics of both bacterial and fungal communities were analyzed through MiSeq sequencing method. The results showed that the bioaugmented BAF displayed obviously better performance for decolorization, COD removal and detoxification of ARB wastewater than the other two which were inoculated with activated sludge (AS) and single M...
February 2017: World Journal of Microbiology & Biotechnology
https://www.readbyqxmd.com/read/28095087/binocular-and-accommodative-characteristics-in-a-normal-population
#11
AbbasAli Yekta, Mehdi Khabazkhoob, Hassan Hashemi, Hadi Ostadimoghaddam, Somayeh Ghasemi-Moghaddam, Javad Heravian, Asgar Doostdar, Payam Nabovati
PURPOSE: To study binocular and accommodative characteristics and their associations with age and gender in an Iranian young adult population. METHODS: In this cross-sectional study, multistage cluster sampling was done from the students of Mashhad University of Medical Sciences. All participants had visual acuity, refraction, and cover tests followed by measurements of the near point of convergence (NPC), amplitude of accommodation (AA), monocular and binocular accommodative facility (MAF and BAF) using ±2...
January 17, 2017: Strabismus
https://www.readbyqxmd.com/read/28078134/malignant-transformation-of-biliary-adenofibroma-a-rare-biliary-cystic-tumor
#12
Scott M Thompson, Benjamin Zendejas-Mummert, Mindy L Hartgers, Sudhakar K Venkatesh, Thomas C Smyrk, Amit Mahipal, Rory L Smoot
Biliary adenofibromas (BAFs) are rare, benign biliary cystic tumors with potential for malignant transformation. Of the eleven prior cases of BAF reported in the literature, six showed evidence of malignant transformation. We describe the clinical, imaging and pathology features of two cases of malignant BAF and review the existing literature to raise awareness of this entity and provide additional tools for diagnosing this rare tumor Additionally, we identified a loss of function mutation in the cyclin-dependent kinase inhibitor 2A (CDKN2A) tumor suppressor gene in a malignant caudate lobe BAF, thereby providing potential insight into the molecular pathogenesis of BAF malignant transformation...
December 2016: Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/28053089/individual-bromodomains-of-polybromo-1-contribute-to-chromatin-association-and-tumor-suppression-in-clear-cell-renal-carcinoma
#13
Elizabeth G Porter, Emily C Dykhuizen
The architecture of chromatin is governed, in part, by ATP-dependent chromatin remodelers. These multiprotein complexes contain targeting domains that recognize post-translational marks on histones. One such targeting domain is the bromodomain (BD), which recognizes acetyl-lysines and recruits proteins to sites of acetylation across the genome. Polybromo1 (PBRM1), a subunit of the Polybromo-associated BRG1- or hBRM-associated factors (PBAF) chromatin remodeler, contains six tandem BDs and is frequently mutated in clear cell renal cell carcinoma (ccRCC)...
February 17, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28040337/bioaccumulation-of-short-chain-chlorinated-paraffins-in-a-typical-freshwater-food-web-contaminated-by-e-waste-in-south-china-bioaccumulation-factors-tissue-distribution-and-trophic-transfer
#14
Runxia Sun, Xiaojun Luo, Bin Tang, Laiguo Chen, Yu Liu, Bixian Mai
Short chain chlorinated paraffins (SCCPs) are under review for inclusion into the Stockholm Convention on Persistent Organic Pollutants. However, limited information is available on their bioaccumulation and biomagnification in ecosystems, which is hindering evaluation of their ecological and health risks. In the present study, wild aquatic organisms (fish and invertebrates), water, and sediment collected from an enclosed freshwater pond contaminated by electronic waste (e-waste) were analyzed to investigate the bioaccumulation, distribution, and trophic transfer of SCCPs in the aquatic ecosystem...
March 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28034558/bioaccumulation-and-trophic-transfer-of-pharmaceuticals-in-food-webs-from-a-large-freshwater-lake
#15
Zhengxin Xie, Guanghua Lu, Zhenhua Yan, Jianchao Liu, Peifang Wang, Yonghua Wang
Pharmaceuticals are increasingly detected in environmental matrices, but information on their trophic transfer in aquatic food webs is insufficient. This study investigated the bioaccumulation and trophic transfer of 23 pharmaceuticals in Taihu Lake, China. Pharmaceutical concentrations were analyzed in surface water, sediments and 14 aquatic species, including plankton, invertebrates and fish collected from the lake. The median concentrations of the detected pharmaceuticals ranged from not detected (ND) to 49 ng/L in water, ND to 49 ng/g dry weight (dw) in sediments, and from ND to 130 ng/g dw in biota...
March 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28030837/bafilomycin-a1-triggers-proliferative-potential-of-senescent-cancer-cells-in-vitro-and-in-nod-scid-mice
#16
Halina Was, Kamila Barszcz, Joanna Czarnecka, Agata Kowalczyk, Tytus Bernas, Ewelina Uzarowska, Paulina Koza, Agata Klejman, Katarzyna Piwocka, Bozena Kaminska, Eva Sikora
Anticancer therapies that induce DNA damage tend to trigger senescence in cancer cells, a process known as therapy-induced senescence (TIS). Such cells may undergo atypical divisions, thus contributing to tumor re-growth. Accumulation of senescent cancer cells reduces survival of patients after chemotherapy. As senescence interplays with autophagy, a dynamic recycling process, we sought to study whether inhibition of autophagy interferes with divisions of TIS cells. We exposed human colon cancer HCT116 cells to repeated cycles of a chemotherapeutic agent - doxorubicin (doxo) and demonstrated induction of hallmarks of TIS (e...
February 7, 2017: Oncotarget
https://www.readbyqxmd.com/read/27984864/electric-potential-invariants-and-ions-in-molecules-effective-potentials-for-molecular-rydberg-states
#17
Stephen L Coy, David D Grimes, Yan Zhou, Robert W Field, Bryan M Wong
The dependence of multipole moments and polarizabilities on external fields appears in many applications including biomolecular molecular mechanics, optical non-linearity, nanomaterial calculations, and the perturbation of spectroscopic signatures in atomic clocks. Over a wide range of distances, distributed multipole and polarizability potentials can be applied to obtain the variation of atom-centered atoms-in-molecules electric properties like bonding-quenched polarizability. For cylindrically symmetric charge distributions, we examine single-center and atom-centered effective polarization potentials in a non-relativistic approximation for Rydberg states...
December 21, 2016: Journal of Chemical Physics
https://www.readbyqxmd.com/read/27979647/bioaccessibility-of-u-th-and-pb-in-solid-wastes-and-soils-from-an-abandoned-uranium-mine
#18
Michael Foulkes, Geoffrey Millward, Samuel Henderson, William Blake
Bioaccessible U, Th, Pb and the (238)U decay products (214)Pb and (210)Pb have been determined, using a modified Unified BARGE Method (UBM), in waste solids and soils from an abandoned uranium mine in South West England, UK. Maximum aqua regia extractable concentrations for U, Th and Pb were 16,200, 3.8 and 4750 μg g(-1), respectively. (238)U had highest activity concentrations near the mine shaft, where the decay products(214)Pb and (210)Pb had values of 235 and 180 Bq g(-1), respectively. UBM extractions gave mean gastro-intestinal bioaccessibility factors (BAFs) for U and Pb in the waste solids of 0...
December 12, 2016: Journal of Environmental Radioactivity
https://www.readbyqxmd.com/read/27960036/emerin-self-assembly-mechanism-role-of-the-lem-domain
#19
Camille Samson, Florian Celli, Kitty Hendriks, Maximilian Zinke, Nada Essawy, Isaline Herrada, Ana-Andreea Arteni, François-Xavier Theillet, Béatrice Alpha-Bazin, Jean Armengaud, Catherine Coirault, Adam Lange, Sophie Zinn-Justin
At the nuclear envelope, the inner nuclear membrane protein emerin contributes to the interface between the nucleoskeleton and the chromatin. Emerin is an essential actor of the nuclear response to a mechanical signal. Genetic defects in emerin cause Emery-Dreifuss muscular dystrophy. It was proposed that emerin oligomerization regulates nucleoskeleton binding, and impaired oligomerization contributes to the loss of function of emerin disease-causing mutants. We here report the first structural characterization of emerin oligomers...
December 13, 2016: FEBS Journal
https://www.readbyqxmd.com/read/27956235/valproic-acid-protects-against-mpp-mediated-neurotoxicity-in-sh-sy5y-cells-through-autophagy
#20
Y Zhang, J Y Wu, L H Weng, X X Li, L J Yu, Y Xu
Autophagy is a common physiological activity in cells. Studies show that dysregulation of autophagy is involved in the pathogenesis of Parkinson's disease (PD). As a commonly used anti-epileptic drug, valproic acid (VPA) has shown neuroprotective effects in PD. The aim of this study was to explore whether the autophagy induced by VPA involved in the neuroprotective effects in PD cell model. We found that VPA treatment counteracted MPP(+)-caused autophagic flux impairment. Forthermore, VPA could alleviates apoptosis, reduce reactive oxygen species (ROS) production and mitochondrial membrane potential (MMP) loss caused by MPP(+)...
December 9, 2016: Neuroscience Letters
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