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Amiya Kumar Ghosh, Theresa Mau, Martin O'Brien, Sanjay Garg, Raymond Yung
Adipose tissue dysfunction in aging is associated with inflammation, metabolic syndrome and other diseases. We propose that impaired protein homeostasis due to compromised lysosomal degradation (micro-autophagy) might promote aberrant ER stress response and inflammation in aging adipose tissue. Using C57BL/6 mouse model, we demonstrate that adipose tissue-derived stromal vascular fraction (SVF) cells from old (18-20 months) mice have reduced expression of autophagy markers as compared to the younger (4-6 months) cohort...
October 24, 2016: Aging
Changyong Wu, Yuexi Zhou, Yi Wang, Mingkun Guo
Two sets of BAF - ozonation systems, with (System-A) and without (System-B) Fe(2+) dosing into BAF, were used for organic micropollutants (OMPs) and phosphorus removal in the advanced treatment of petrochemical secondary effluent. Pilot scale study showed that when the influent COD, TP and TSS were 73.0, 1.40 and 24.6mgL(-1), the effluent COD, TP and TSS were 48.9, 0.32, 7.78mgL(-1) for System-A with the ozone and Fe(2+) dosage of 25mgL(-1) and 0.08mmolL(-1), and 60.2, 1.16, 6.44mgL(-1) for System-B with the ozone dosage of 25mgL(-1)...
October 14, 2016: Journal of Hazardous Materials
Yanping Wang, Jin Li, Thomas F Kolon, Alicia Olivant Fisher, T Ernesto Figueroa, Ahmad H BaniHani, Jennifer A Hagerty, Ricardo Gonzalez, Paul H Noh, Rosetta M Chiavacci, Kisha R Harden, Debra J Abrams, Deborah Stabley, Cecilia E Kim, Katia Sol-Church, Hakon Hakonarson, Marcella Devoto, Julia Spencer Barthold
BACKGROUND: Copy number variation (CNV) is a potential contributing factor to many genetic diseases. Here we investigated the potential association of CNV with nonsyndromic cryptorchidism, the most common male congenital genitourinary defect, in a Caucasian population. METHODS: Genome wide genotyping were performed in 559 cases and 1772 controls (Group 1) using Illumina HumanHap550 v1, HumanHap550 v3 or Human610-Quad platforms and in 353 cases and 1149 controls (Group 2) using the Illumina Human OmniExpress 12v1 or Human OmniExpress 12v1-1...
October 21, 2016: BMC Urology
Liwen Qiang, Meng Chen, Ling-Yan Zhu, Wei Wu, Qiang Wang
As one of the most popular carbon-based nano-materials, graphene oxide (GO) has the potential to be released in aquatic environment and interact with some coexistent organic pollutants, such as perfluorooctane sulfonate (PFOS), which is an emerging persistent organic pollutant. In this study, the adsorption of PFOS on GO in presence of fulvic acid (FA), the impacts of GO and FA on PFOS toxicokinetics in carp (Cyprinus carpio), and in vitro digestion behaviors were examined. The results indicated that PFOS could be strongly adsorbed on GO with a Freundlich affinity coefficient KF of 580 ± 205 (mg/g)/(mg/L)n, while the adsorption was suppressed by FA due to competitive adsorption...
October 10, 2016: Environmental Science & Technology
Yunqiao Zhou, Tieyu Wang, Zhaoze Jiang, Xiaoxiao Kong, Qifeng Li, Yajun Sun, Pei Wang, Zhaoyang Liu
In the present study, the concentrations and proportions of perfluoroalkyl substances (PFASs) in water and sediments (in different seasons) from the Qing River were investigated. The highest concentration of PFASs in water (207.59 ng L(-1)) was found in summer. The composition of PFASs in water changed with time, perfluorobutane sulfonate (PFBS) was the predominant compound in spring and summer, while long-chain PFASs, perfluorooctanoic acid (PFOA) and perfluorooctane sulfonate (PFOS), started to increase in autumn and winter...
October 3, 2016: Chemosphere
Shivika S Gupta, Matthew R Zeglinski, Sunil G Rattan, Natalie M Landry, Saeid Ghavami, Jeffrey T Wigle, Thomas Klonisch, Andrew J Halayko, Ian M C Dixon
The incidence of heart failure with concomitant cardiac fibrosis is very high in developed countries. Fibroblast activation in heart is causal to cardiac fibrosis as they convert to hypersynthetic cardiac myofibroblasts. There is no known treatment for cardiac fibrosis. Myofibroblasts contribute to the inappropriate remodeling of the myocardial interstitium, which leads to reduced cardiac function and ultimately heart failure. Elevated levels of autophagy have been linked to stress-induced ventricular remodeling and other cardiac diseases...
October 1, 2016: Oncotarget
Soheila Rezaitabar, Abbas Esmaili Sari, Nader Bahramifar, Zohreh Ramezanpour
This study was conducted to determine Microcystin LR concentration in the aquatic ecosystem of the Anzali wetland in Iran. Extraction and detection of MC-LR from the water and fish samples was conducted by the SPE and HPLC-UV apparatus. Our results showed that among toxic cyanobacteria, Anabaena was the dominant genera during the study period. The results indicated that MC-LR content in water ranged from 0.18 to 3.02μg/L in dissolved fraction and undetectable level to 1.13μg/L in cellular fraction, in all three seasons...
September 30, 2016: Science of the Total Environment
Marja L Boström, Gustaf Ugge, Jan Åke Jönsson, Olof Berglund
Although reports of pharmaceutical bioconcentration in aquatic organisms are increasing, less is known about trophic transfer in aquatic food webs. In the present study, we tested the bioaccumulation and trophodynamics of sertraline and fluoxetine, two selective serotonin reuptake inhibitors (SSRIs) frequently detected in aquatic environments, by exposing constructed aquatic food chains under controlled laboratory conditions. Both of these ionizable, weak base pharmaceuticals, showed lower bioaccumulation factors (BAFs) with increasing trophic level, i...
October 3, 2016: Environmental Toxicology and Chemistry
Tao Lu, Jumei Li, Xiaoqing Wang, Yibing Ma, Erik Smolders, Nanwen Zhu
The difference in availability between soil metals added via biosolids and soluble salts was not taken into account in deriving the current land-applied biosolids standards. In the present study, a biosolids availability factor (BAF) approach was adopted to investigate the ecological thresholds for copper (Cu) in land-applied biosolids and biosolid-amended agricultural soils. First, the soil property-specific values of HC5add (the added hazardous concentration for 5% of species) for Cu(2+) salt amended were collected with due attention to data for organisms and soils relevant to China...
December 1, 2016: Journal of Environmental Management
Slađana Č Alagić, Snežana B Tošić, Mile D Dimitrijević, Jelena V Petrović, Dragana V Medić
The samples of spatial soils and different organs of Prunus persica L. Batech and Malus domestica were analyzed by methods such as inductively coupled plasma optical emission spectroscopy (ICP-OES), Hierarchical Cluster Analysis (HCA), One-way ANOVA, and calculation of biological accumulation factors (BAFs) with the aim of investigating whether these methods may help in the evaluation of trace metals in plants, as well as in the estimation of plant bioaccumulation potentials. ICP-OES provided accurate data on present concentrations of Cu, Zn, Pb, As, Cd, and Ni which showed that most concentrations were in normal ranges, except in some cases for Cu, Zn, and As...
February 15, 2017: Food Chemistry
Bobo Guo, Deqi Jiao, Jing Wang, Kai Lei, Chunye Lin
In order to study element accumulation and trophic transfer in the food web, sixteen benthic invertebrate species and nine fish species were collected from the Daliao River estuary for analysis of toxic elements and nitrogen stable isotope in the muscle tissue. The concentrations ranged between 1.44-17.98, 0.01-9.30, 0.17-36.15, 0.7-145.4, 0.01-0.33, 0.14-14.88, 0.10-2.51, 0.02-0.14, and 19.3-221.1mgkg(-1) for As, Cd, Cu, Hg, Ni, Pb, Sb, and Zn, respectively. As, Cd, Cu, and Zn were significantly higher in the benthic invertebrates than in fish, whereas Hg and Sb were significantly lower...
September 19, 2016: Marine Pollution Bulletin
Boris Kolar, Lovro Arnuš, Boštjan Križanec, Willie Peijnenburg, Mojca Kos Durjava
The selective uptake of polybrominated diphenyl ethers (PBDEs) by oligochaetes makes it possible to assess the bioaccumulation of individual congeners in commercial mixtures. Twenty-one congeners from three BDE commercial mixtures (TBDE-71, TBDE-79 and TBDE-83R) and as individual congeners (BDE-77, BDE-126, BDE-198 and BDE-204) were tested on Tubifex tubifex in accordance with the OECD TG 315 "Bioaccumulation in Sediment-Dwelling Benthic Oligochaetes". All the congeners that were spiked in the sediment were detected at the end of the uptake phase and at the end of the experiment...
2016: Acta Chimica Slovenica
Vojtěch Ettler, Ladislav Polák, Martin Mihaljevič, Gildas Ratié, Jérémie Garnier, Cécile Quantin
The laterite Ni ore smelting operations in Niquelândia and Barro Alto (Goiás State, Brazil) have produced large amounts of fine-grained smelting wastes, which have been stockpiled on dumps and in settling ponds. We investigated granulated slag dusts (n = 5) and fly ash samples (n = 4) with a special focus on their leaching behaviour in deionised water and on the in vitro bioaccessibility in a simulated gastric fluid, to assess the potential exposure risk for humans. Bulk chemical analyses indicated that both wastes contained significant amounts of contaminants: up to 2...
September 14, 2016: Environmental Geochemistry and Health
Teng-Fei Ma, You-Peng Chen, Jia Kang, Xu Gao, Jin-Song Guo, Fang Fang, Xiao-Tian Zhang
Biological aerated filters (BAFs) are widely used for the treatment of micropolluted surface water. However, the biological process produces dissolved organic nitrogen (DON), which, as precursors of nitrogenous disinfection by-products, pose potential threats to drinking water safety. Therefore, to control DON in BAF effluent, it is necessary to study the influence of BAF operation parameters on DON production. In this study, the influence of filtration velocity in a BAF on DON production was investigated. Under different filtration velocity (0...
September 9, 2016: Environmental Science and Pollution Research International
Mostafa Mazloum Farsi Baf, Mozhgan Mazloum Farsi Baf, Fatemeh Noorollahi, Morteza Mazloum Farsi Baf
OBJECTIVE: Congenital hypothyroidism (CH) is one of the most common treatable causes of mental retardation and neurodevelopmental impairment. METHODS: In a cross-sectional study, 114342 neonates born in 28 cities in Razavi Khorasan province, northeastern Iran from Aril 2013 to March 2014, were screened for congenital hypothyroidism by taking blood sample from heel prick. The newborns with TSH ≥5 mIU/L were recalled for further assessment of TSH concentration in serum sample...
September 9, 2016: Journal of Clinical Research in Pediatric Endocrinology
Christina Bachmann, Huong Nguyen, Joachim Rosenbusch, Linh Pham, Tamara Rabe, Megha Patwa, Godwin Sokpor, Rho H Seong, Ruth Ashery-Padan, Ahmed Mansouri, Anastassia Stoykova, Jochen F Staiger, Tran Tuoc
Neurogenesis is a key developmental event through which neurons are generated from neural stem/progenitor cells. Chromatin remodeling BAF (mSWI/SNF) complexes have been reported to play essential roles in the neurogenesis of the central nervous system. However, whether BAF complexes are required for neuron generation in the olfactory system is unknown. Here, we identified onscBAF and ornBAF complexes, which are specifically present in olfactory neural stem cells (oNSCs) and olfactory receptor neurons (ORNs), respectively...
September 2016: PLoS Genetics
Joshua A Smith, Kenton R Holden, Michael J Friez, Julie R Jones, Michael J Lyons
Recent studies have identified mutations in the ARID1B gene responsible for neurodevelopmental delays, intellectual disability, growth delay, and dysmorphic features. ARID1B encodes a subunit of the BAF chromatin-remodeling complex, and mutations in multiple components of the BAF complex have been implicated as causes of Coffin-Siris syndrome, Nicolaides-Baraitser syndrome, and non-syndromic intellectual disability. The majority of documented pathogenic ARID1B mutations to date have arisen in a sporadic, de novo manner with no reports of inheritance of a pathogenic mutation from an affected parent...
August 29, 2016: American Journal of Medical Genetics. Part A
Wei Guo, Yu Wang, Zhu Wang, Yan-Ping Wang, Hong Zheng
Chemotherapy, radiotherapy, and endocrinotherapy are documented to induce autophagy among breast cancer cells, but the role of autophagy in this disease has been attributed to be cytoprotective as well as tumor-suppressing. Thus we studied MDA-MB-231 and SK-BR-3 breast cancer cell lines treated with epirubicin (EPI) to assess autophagy and apoptosis. We found out that EPI induced apoptosis and autophagy in both cell lines, the lysosomal inhibitor bafilomycin A1 (BAF) inhibited cellular autophagy and enhanced EPI-triggered apoptosis perhaps due to inhibition of autolysosome formation, which then inhibited autophagic effects of engulfing and clearing damaged mitochondria...
August 25, 2016: Cancer Science
Pi Wei Zhang, Chong Tian, Fang Yi Xu, Zhuo Chen, Raynard Burnside, Wei Jie Yi, Si Yun Xiang, Xiao Xie, Nan Nan Wu, Hui Yang, Na Na4 Zhao, Xiao Lei Ye, Chen Jiang1 Ying
Bovine aortic endothelial cells (BAECs) were cultured with high glucose (33 mmol/L), 4 mg/L green tea polyphenols (GTPs) or 4 mg/L GTPs co-treatment with high glucose for 24 h in the presence or absence of Bafilomycin-A1 (BAF). We observed that high glucose increased the accumulation of LC3-II. Treatment with BAF did not further increase the accumulation of LC3-II. Results also showed an increased level of p62 and decreased Beclin-1. However, GTPs showed inversed trends of those proteins. Furthermore, GTPs co-treatment with high glucose decreased the level of LC3-II and a much higher accumulation of LC3-II was observed in the presence of BAF in comparison with high glucose alone...
July 2016: Biomedical and Environmental Sciences: BES
Shi He, Chao-chao Gu, Xin Wei, Sheng-lin Huang, Zhen-hong Liu, Gang Xue, Pin Gao
Effect of low-concentration ciprofloxacin (CIP) on nitrification and nitrifying microorganisms of biofilms was studied in biological aerated filters (BAF). Quantitative PCR (qPCR) was used to determine the abundance variance of four ciprofloxacin resistance genes (CIP-ARGs) during nitrification in biofilms. The correlations between the abundances of CIP-ARGs and nitrifying microorganisms were also discussed. The results showed that CIP had little influence on the ammonium oxidation process of biofilm microorganisms, whereas inhibition of the nitrite oxidation process was found...
April 15, 2016: Huan Jing Ke Xue= Huanjing Kexue
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