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Tracheal stenosis

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https://www.readbyqxmd.com/read/27916370/tanshinone-iia-attenuates-epithelial-mesenchymal-transition-to-inhibit-the-tracheal-narrowing
#1
Hongtao Duan, Lijie Ma, Honggang Liu, Yong Zhang, Zhipei Zhang, Xiaolong Yan, Xiaofei Li
BACKGROUND: This study examines the effects of tanshinone IIA (TIIA) on epithelial-mesenchymal transition (EMT) in tracheal transplantation and the ability of TIIA to inhibit tracheal narrowing after tracheal transplantation. Mechanisms that may be involved in this process are also explored. METHODS: Human bronchial epithelial cells were treated in vitro with TGF-β1 for 72 h. The cells were pretreated with TIIA (40 μg/mL) or DMSO for 2 h before TGF-β1 stimulation...
November 2016: Journal of Surgical Research
https://www.readbyqxmd.com/read/27890997/complete-subglottic-tracheal-stenosis-managed-with-rigid-bronchoscopy-and-t-tube-placement
#2
Kuruswamy Thurai Prasad, Sahajal Dhooria, Inderpaul Singh Sehgal, Ashutosh Nath Aggarwal, Ritesh Agarwal
Surgery is the preferred treatment modality for benign tracheal stenosis. Interventional bronchoscopy is used as a bridge to surgery or in instances when surgery is not feasible or has failed. Stenosis in the subglottic trachea is particularly a treatment challenge, in view of its proximity to the vocal cords. Herein, we describe a patient with complete tracheal stenosis in the subglottic region, which developed after prolonged intubation and mechanical ventilation. The patient developed recurrent stenosis despite multiple surgical and endoscopic procedures...
November 2016: Lung India: Official Organ of Indian Chest Society
https://www.readbyqxmd.com/read/27885873/effects-of-artificial-tracheal-fixation-on-tracheal-epithelial-regeneration-and-prevention-of-tracheal-stenosis
#3
Yuta Nakaegawa, Ryosuke Nakamura, Yasuhiro Tada, Ryo Suzuki, Toshiaki Takezawa, Tatsuo Nakamura, Koichi Omori
CONCLUSION: Tight fixation of the artificial trachea is important for epithelialization and tracheal stenosis. OBJECTIVE: The authors have developed an artificial trachea and have used it for tracheal reconstruction. Although various studies on tracheal reconstruction have been conducted, no studies have examined the effect of artificial tracheal fixation on tracheal stenosis and regeneration. Therefore, the purpose of the present study was to evaluate the effect of artificial tracheal fixation...
November 25, 2016: Acta Oto-laryngologica
https://www.readbyqxmd.com/read/27882259/right-lung-agenesis-with-tracheal-stenosis-due-to-complete-tracheal-rings-and-postpneumonectomy-like-syndrome-treated-with-tissue-expander-placement
#4
Yashwant Agrawal, Sandeep Patri, Jagadeesh K Kalavakunta
Congenital lung agenesis is an extremely rare condition with an estimated prevalence of 34 in 1,000,000 live births. It is often associated with other congenital malformations of the skeletal, cardiovascular, urogenital, and gastrointestinal systems. We discuss the case of a 5-month-old who presented with increasing stridor over 1 month. Imaging revealed right lung agenesis, complete dextromalposition of heart, and compression of distal trachea. An intrathoracic saline tissue expander was placed which marked improved distal tracheal stenosis...
2016: Case Reports in Pulmonology
https://www.readbyqxmd.com/read/27873529/tracheal-allotransplantation-and-regeneration
#5
P Delaere, M Molitor
Non-malignant and malignant obstruction of the tracheal airway causes significant morbidity and mortality. With increased use of artificial airways, benign and iatrogenic complications are increasing. A tracheal stenosis that is less than 5 cm in length can be resected with end-to-end anastomosis. Longer tracheal lesions can be treated in a palliative way by placement of a stent to secure airway lumen patency. The management of tracheal defects is an evolving field. Tracheal transplantation and tracheal regeneration may provide major treatment advances to cases with long-segment tracheal involvement...
2016: Acta Chirurgiae Plasticae
https://www.readbyqxmd.com/read/27873304/stent-induced-tracheal-stenosis-can-be-predicted-by-il-8-expression-in-rabbits
#6
Elena Arellano-Orden, Carolina Serrano, Ana Montes-Worboys, Verónica Sánchez-López, Alicia Laborda, Fernando Lostalé, Celia Lahuerta, Francisco Rodríguez-Panadero, Miguel Ángel de Gregorio
BACKGROUND: Bare metal stents may cause complications like fibrous encapsulation, granulation and tracheal stenosis. We investigated the behavior of three commercially available stents in vivo (rabbits) and in vitro (co-culture of those stents with epithelial and fibroblast cell lines). Also, we investigated whether development of tracheal stenosis could be predicted by any biological marker. METHODS: The tracheae of 30 rabbits were implanted with either nitinol stents, with or without paclitaxel elution, or a cobalt-based stent...
November 22, 2016: European Journal of Clinical Investigation
https://www.readbyqxmd.com/read/27871527/two-lost-airways-and-one-unexpected-problem-undiagnosed-tracheal-stenosis-in-a-morbidly-obese-patient
#7
Miguel A Cobas, Nicole D Martin, Heather B Barkin
Anesthetic care of the morbidly obese is complex due to anatomic and physiologic alterations. Airway management in particular can be challenging. High body mass index is predictive of difficult ventilation and possibly difficult intubation. Other airway anomalies, such as tracheal stenosis, add to the complexity of airway management. Tracheal stenosis, a form of central airway obstruction, may be challenging to diagnose, especially in the obese. Comorbidities can mask the diagnosis and routine imaging may fail to identify the pathology...
December 2016: Journal of Clinical Anesthesia
https://www.readbyqxmd.com/read/27862085/rabbit-model-of-tracheal-stenosis-using-cylindrical-diffuser
#8
Hyoung Shin Lee, Sung Won Kim, Chulho Oak, Hyun Wook Kang, Junghwan Oh, Min Jung Jung, Sung Bin Kim, Jun Hee Won, Kang Dae Lee
BACKGROUND AND OBJECTIVE: Variable methods of animal model have been introduced to develop tracheal stenosis. However, none of the prior models allow for predictable determination of the grade of stenosis. This study sought to establish an animal model of tracheal stenosis by using a cylindrical diffuser and to evaluate the feasibility of a reproducible model. STUDY DESIGN/MATERIALS AND METHODS: A cylindrical diffuser was developed to have a 5 mm active segment to emit laser light circumferentially...
November 16, 2016: Lasers in Surgery and Medicine
https://www.readbyqxmd.com/read/27861870/iatrogenic-burns-of-the-neckline-in-a-patient-with-tetraparesis-during-tracheotomy
#9
Anna Smędra, Ewa Meissner, Maciej Barzdo, Przemysław Grabowski, Michał Kartasiński, Wojciech Krajewski, Jarosław Berent
The paper presents a case of an atypical iatrogenic complication after tracheotomy analyzed on the basis of the case dossier materials submitted to the authors by the court of justice to prepare a forensic medical opinion concerning the correctness of the medical procedure. A 37-year-old woman was brought by the ambulance service to the hospital with acute respiratory failure due to post-tracheostomy tracheal stenosis. Tracheotomy was performed on an emergency basis. The patient suffered severe burns of the chest and neck...
November 10, 2016: Journal of Forensic Sciences
https://www.readbyqxmd.com/read/27859296/slide-tracheoplasty-outcomes-in-children-with-congenital-pulmonary-malformations
#10
Michael A DeMarcantonio, Catherine K Hart, Christina J Yang, Meredith Tabangin, Michael J Rutter, Roosevelt Bryant, Peter B Manning, Alessandro de Alarcón
OBJECTIVES/HYPOTHESIS: Evaluate and compare surgical outcomes of slide tracheoplasty for the treatment of congenital tracheal stenosis in children with and without pulmonary malformations. STUDY DESIGN: Retrospective chart review at a tertiary care pediatric medical center. METHODS: We identified patients with tracheal stenosis who underwent slide tracheoplasty from 2001 to 2014, and a subset of these patients who were diagnosed with congenital pulmonary malformations...
November 15, 2016: Laryngoscope
https://www.readbyqxmd.com/read/27859294/tgf-%C3%AE-antagonist-attenuates-fibrosis-but-not-luminal-narrowing-in-experimental-tracheal-stenosis
#11
Juan L Antón-Pacheco, Alicia Usategui, Iván Martínez, Carmen M García-Herrero, Antonio P Gamez, Montserrat Grau, Ana M Martínez, José L Rodríguez-Peralto, José L Pablos
OBJECTIVE: Acquired tracheal stenosis (ATS) is an unusual disease often secondary to prolonged mechanical trauma. Acquired tracheal stenosis pathogenesis involves inflammation and subsequent fibrosis with narrowing of the tracheal lumen. Transforming growth factor-β1 (TGF-β) represents a pivotal factor in most fibrotic processes, and therefore a potential target in this context. The aim of this study is to analyze the role of TGF-β as a target for anti-fibrotic interventions in tracheal stenosis...
November 16, 2016: Laryngoscope
https://www.readbyqxmd.com/read/27853078/recurred-post-intubation-tracheal-stenosis-treated-with-bronchoscopic-cryotherapy
#12
Ye-Ryung Jung, Joon Taek Jeong, Myoung Kyu Lee, Sang-Ha Kim, Suk Joong Yong, Seok Jeong Lee, Won-Yeon Lee
Post-intubation tracheal stenosis accounts for the greatest proportion of whole-cause tracheal stenosis. Treatment of post-intubation tracheal stenosis requires a multidisciplinary approach. Surgery or an endoscopic procedure can be used, depending on the type of stenosis. However, the efficacy of cryotherapy in post-intubation tracheal stenosis has not been validated. Here, we report a case of recurring post-intubation tracheal stenosis successfully treated with bronchoscopic cryotherapy that had previously been treated with surgery...
2016: Internal Medicine
https://www.readbyqxmd.com/read/27847813/jet-ventilation-during-rigid-bronchoscopy-in-adults-a-focused-review
#13
REVIEW
Laurie Putz, Alain Mayné, Anne-Sophie Dincq
The indications for rigid bronchoscopy for interventional pulmonology have increased and include stent placements and transbronchial cryobiopsy procedures. The shared airway between anesthesiologist and pulmonologist and the open airway system, requiring specific ventilation techniques such as jet ventilation, need a good understanding of the procedure to reduce potentially harmful complications. Appropriate adjustment of the ventilator settings including pause pressure and peak inspiratory pressure reduces the risk of barotrauma...
2016: BioMed Research International
https://www.readbyqxmd.com/read/27846248/elective-tracheotomy-practices-in-turkey
#14
Bulent Gucyetmez, Hakan Korkut Atalan, Nahit Cakar
OBJECTIVES: Elective tracheotomy (ET) procedures in intensive care units (ICU) might be different in accordance with countries and ICUs' features. The aim of the present study was to search the epidemiology of ET procedures in Turkey. METHODS: A questionnaire which consists of 43 questions was sent by e-mail to 238 ICUs which were officially recognized by The Turkish Ministry of Health. All answers were obtained between August 1, 2015 and August 31, 2015. RESULTS: Two hundred and three ICUs (85...
2016: PloS One
https://www.readbyqxmd.com/read/27833870/use-of-conchal-cartilages-for-laryngotracheal-stenosis-experiences-at-a-tertiary-care-hospital-of-eastern-india
#15
Santosh Kumar Swain, Neha Singh, Rankanidhi Samal, Santosh Kumar Pani, Mahesh Chandra Sahu
To describe the experience of anterior cricotracheal split with insertion of conchal cartilage graft in the treatment of subglottic and tracheal stenosis at a tertiary care hospital of eastern India. Six patients were included in the study, in the age group of 20-48 years. Out of which five patients were successfully decannulated after 3 months of laryngotracheal reconstruction with help of conchal cartilage. One case was undergone resection anastomosis after failure of the above technique. Successful restoration of the airway with decannulation in five cases and failure in one case...
December 2016: Indian Journal of Otolaryngology and Head and Neck Surgery
https://www.readbyqxmd.com/read/27824004/paclitaxel-drug-eluting-tracheal-stent-could-reduce-granulation-tissue-formation-in-a-canine-model
#16
Ting Wang, Jie Zhang, Juan Wang, Ying-Hua Pei, Xiao-Jian Qiu, Yu-Ling Wang
BACKGROUND: Currently available silicone and metallic stents for tracheal stenosis are associated with many problems. Granulation proliferation is one of the main complications. The present study aimed to evaluate the efficacy of paclitaxel drug-eluting tracheal stent in reducing granulation tissue formation in a canine model, as well as the pharmacokinetic features and safety profiles of the coated drug. METHODS: Eight beagles were randomly divided into a control group (bare-metal stent group, n = 4) and an experimental group (paclitaxel-eluting stent group, n = 4)...
2016: Chinese Medical Journal
https://www.readbyqxmd.com/read/27792824/a-novel-approach-to-excision-of-distal-tracheal-granulation-tissue-in-tracheostomy-patients-with-difficult-anatomy
#17
Allison Rasband-Lindquist, Keith Sale
Tracheostomy predisposes patients to various complications. The most common late complication is granuloma formation; others include tracheal stenosis, bleeding, infection, and fistula development. Small granulomas may not require treatment, but large ones necessitate removal to prevent bleeding, obstruction, respiratory distress and, in rare cases, death. Various treatment options have been described, but no single modality has proved to be superior. We describe a novel approach to treating substomal tracheal granulation by using trans-stomal Coblation for patients whose granulation is difficult to visualize...
October 2016: Ear, Nose, & Throat Journal
https://www.readbyqxmd.com/read/27784503/-montgomery-t-tube-in-the-treatment-of-tracheal-stenosis
#18
J W Wang, Y B Dong, Y Jin
No abstract text is available yet for this article.
October 12, 2016: Chinese Journal of Tuberculosis and Respiratory Diseases
https://www.readbyqxmd.com/read/27777507/fully-covered-metallic-stents-for-the-treatment-of-benign-airway-stenosis
#19
Caroline Dahlqvist, Sebahat Ocak, Maximilien Gourdin, Anne Sophie Dincq, Laurie Putz, Jean-Paul d'Odémont
Introduction. We herein report our experience with new fully covered self-expanding metallic stents in the setting of inoperable recurrent benign tracheobronchial stenosis. Methods. Between May 2010 and July 2014, 21 Micro-Tech® FC-SEMS (Nanjing Co., Republic of Korea) were placed in our hospital in 16 patients for inoperable, recurrent (after dilatation), and symptomatic benign airway stenosis. Their medical files were retrospectively reviewed in December 2014, with focus on stent's tolerance and durability data...
2016: Canadian Respiratory Journal: Journal of the Canadian Thoracic Society
https://www.readbyqxmd.com/read/27776743/open-airway-reconstruction-in-adults-outcomes-and-prognostic-factors
#20
Marianne Abouyared, Mikhaylo Szczupak, Eric Barbarite, Zoukaa B Sargi, David E Rosow
PURPOSE: The purpose was to assess the success of open tracheal resection and re-anastomosis for non-malignant tracheal stenosis in adults. Successful operations were defined as T-tube or tracheostomy-free status by 6months post-operatively. MATERIALS AND METHODS: Retrospective chart review was performed and data were recorded in a de-identified manner. The primary outcome was T-tube or tracheostomy-free status by 6months following tracheal resection. Clinical and demographic characteristics were evaluated as potential prognostic variables...
September 7, 2016: American Journal of Otolaryngology
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