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https://www.readbyqxmd.com/read/29770166/free-radical-damage-in-ischemia-reperfusion-injury-an-obstacle-in-acute-ischemic-stroke-after-revascularization-therapy
#1
REVIEW
Ming-Shuo Sun, Hang Jin, Xin Sun, Shuo Huang, Fu-Liang Zhang, Zhen-Ni Guo, Yi Yang
Acute ischemic stroke is a common cause of morbidity and mortality worldwide. Thrombolysis with recombinant tissue plasminogen activator and endovascular thrombectomy are the main revascularization therapies for acute ischemic stroke. However, ischemia-reperfusion injury after revascularization therapy can result in worsening outcomes. Among all possible pathological mechanisms of ischemia-reperfusion injury, free radical damage (mainly oxidative/nitrosative stress injury) has been found to play a key role in the process...
2018: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/29765502/the-phenolic-components-of-gastrodia-elata-improve-prognosis-in-rats-after-cerebral-ischemia-reperfusion-by-enhancing-the-endogenous-antioxidant-mechanisms
#2
Anhuan Shi, Jianming Xiang, Fangyan He, Yanping Zhu, Gongbei Zhu, Yuhan Lin, Ningna Zhou
Pharmacological or spontaneous thrombolysis in ischemic stroke triggers an outbreak of reactive oxygen species and results in neuron death. Nrf2-mediated antioxidation in cells has been proved as a pivotal target for neuroprotection. This research reports that phenolic components of Gastrodia elata Blume (PCGE), a traditional Chinese medicine, can alleviate the pathological lesions in the penumbra and hippocampus by increasing the survival of neurons and astrocytes and improve neurofunction and cognition after reperfusion in a rat model of middle cerebral artery occlusion...
2018: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/29751188/reversible-cerebral-vasoconstriction-syndrome-as-an-unusual-complication-of-a-dural-arteriovenous-fistula-treated-with-onyx-embolization
#3
Douglas Gonsales, Fabiano das Gracas, Roberta Santos, Pedro Aguilar-Salinas, Ricardo A Hanel
BACKGROUND: Reversible cerebral vasoconstriction syndrome (RCVS) is a rare entity with an unknown pathophysiology. RCVS has been reported to occur more frequently in women aged 20 to 50 years. Several mechanisms have been postulated involving transient deregulation of cerebral arterial tone, small vessel endothelial dysfunction, biochemical factors, hormonal deregulation, oxidative stress, and genetic predisposition. All these mechanisms and triggers are related with sympathetic over-activation which eventually produce vasoconstriction...
May 8, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29749459/ctrp9-ameliorates-cellular-senescence-via-pgc%C3%A2-1%C3%AE-ampk-signaling-in-mesenchymal-stem-cells
#4
Qun Li, Zhangzhang Zhu, Chengde Wang, Lin Cai, Jianglong Lu, Yongchun Wang, Jiadong Xu, Zhipeng Su, Weiming Zheng, Xianbin Chen
Stroke is the second most common cause of death worldwide, and thus, it imposes great financial burdens on both individuals and society. Mesenchymal stem cell (MSC) therapy is a promising approach for ischemic brain injury. However, MSC treatment potential is progressively reduced with age, limiting their therapeutic efficacy for brain repair post‑stroke. C1q and tumor necrosis factor‑related protein 9 (CTRP9) is a novel cytoprotective cytokine with antioxidant effects, which is highly expressed in brain tissue...
May 9, 2018: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29743967/neuropharmacological-potential-and-delivery-prospects-of-thymoquinone-for-neurological-disorders
#5
REVIEW
Md Jakaria, Duk-Yeon Cho, Md Ezazul Haque, Govindarajan Karthivashan, In-Su Kim, Palanivel Ganesan, Dong-Kug Choi
Thymoquinone (TQ) is an active ingredient isolated from Nigella sativa and has various pharmacological activities, such as protection against oxidative stress, inflammation, and infections. In addition, it might be a potential neuropharmacological agent because it exhibits versatile potential for attenuating neurological impairments. It features greater beneficial effects in toxin-induced neuroinflammation and neurotoxicity. In various models of neurological disorders, it demonstrates emergent functions, including safeguarding various neurodegenerative diseases and other neurological diseases, such as stroke, schizophrenia, and epilepsy...
2018: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/29742480/clinical-benefits-and-pharmacology-of-scutellarin-a-comprehensive-review
#6
REVIEW
Liping Wang, Qiang Ma
Stroke and myocardial infarction are among the most common causes of mortality and disability in the world. The ischemic injury underlying these illnesses is complex, involving intricate interplays among many biological functions including energy metabolism, vascular regulation, hemodynamics, oxidative stress, inflammation, platelet activation, and tissue repair that take place in a context- and time-dependent manner. The current drug therapy of choice is to timely resupply the blood to the ischemic tissue; but reperfusion may introduce additional harm to the tissue through a process known as ischemia/reperfusion injury...
May 6, 2018: Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/29739681/cruciferous-vegetable-intake-and-mortality-in-middle-aged-adults-a-prospective-cohort-study
#7
Nagisa Mori, Taichi Shimazu, Hadrien Charvat, Michihiro Mutoh, Norie Sawada, Motoki Iwasaki, Taiki Yamaji, Manami Inoue, Atsushi Goto, Ribeka Takachi, Junko Ishihara, Mitsuhiko Noda, Hiroyasu Iso, Shoichiro Tsugane
BACKGROUND & AIMS: Cruciferous vegetables contain isothiocyanates, which effectively reduce inflammation and oxidative stress related to chronic diseases, inhibit the bioactivation of procarcinogens, and enhance the excretion of carcinogens. However, at present, no large cohort studies have investigated the effect of cruciferous vegetable on mortality. We aimed to examine the association between cruciferous vegetable intake and all-cause mortality, namely cancer, heart disease, cerebrovascular disease, and injuries, in a large cohort study conducted between 1990 and 1993, in Japan...
April 24, 2018: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/29739082/molecular-mechanism-exploration-of-ischemic-stroke-by-integrating-mrna-and-mirna-expression-profiles
#8
Jianhong Bao, Saijun Zhou, Sipei Pan, Yang Zhang
BACKGROUND: Stroke is one of the leading causes of death worldwide, and ischemic stroke accounts for about 80 percent of all cases. Ischemic stroke is usually caused by a blockage in an artery to the brain. However, its molecular mechanisms remain largely unclear. The integration of mRNA and miRNA expression patterns is an effective strategy to investigate the potential molecular mechanisms of ischemic stroke in posttranscriptional regulation level. METHODS: The mRNA and miRNA expression data were downloaded from the GEO database...
April 1, 2018: Clinical Laboratory
https://www.readbyqxmd.com/read/29731655/immune-regulating-effects-of-exercise-on-cigarette-smoke-induced-inflammation
#9
REVIEW
Ashkan Madani, Katharina Alack, Manuel Jonas Richter, Karsten Krüger
Long-term cigarette smoking (LTCS) represents an important risk factor for cardiac infarction and stroke and the central risk factor for the development of a bronchial carcinoma, smoking-associated interstitial lung fibrosis, and chronic obstructive pulmonary disease. The pathophysiologic development of these diseases is suggested to be promoted by chronic and progressive inflammation. Cigarette smoking induces repetitive inflammatory insults followed by a chronic and progressive activation of the immune system...
2018: Journal of Inflammation Research
https://www.readbyqxmd.com/read/29723859/upregulation-of-nox2-and-nox4-mediated-by-tgf-%C3%AE-signaling-pathway-exacerbates-cerebral-ischemia-reperfusion-oxidative-stress-injury
#10
Zheng Lou, Ai-Ping Wang, Xiao-Ming Duan, Guo-Huang Hu, Gui-Lin Song, Mei-Ling Zuo, Zhong-Bao Yang
BACKGROUND/AIMS: Ischemic stroke is still one of the leading debilitating diseases with high morbidity and mortality. NADPH oxidase (NOX)-derived reactive oxygen species (ROS) play an important role in cerebral ischemia/reperfusion (I/R) injury. However, the mechanism underlying the regulation of ROS generation is still not fully elucidated. This study aims to explore the role of transforming growth beta (TGF-β) signals in ROS generation. METHODS: Sprague-Dawley rats were subjected to I/R injury, and PC-12 cells were challenged by hypoxia/reoxygenation (H/R) and/or treated with activin receptor-like kinase (ALK5) inhibitor Sb505124 or siRNA against ALK5...
April 28, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29723536/4-5-tert-butyl-3-chloro-2-hydroxybenzyl-amino-2-hydroxybenzoic-acid-protects-against-oxygen-glucose-deprivation-reperfusion-injury
#11
Yuexinzi Jin, Xuelian Tang, Xiang Cao, Linjie Yu, Jian Chen, Haoran Zhao, Yan Chen, Lijuan Han, Xinyu Bao, Fei Li, Yun Xu
AIMS: Oxidative stress is one of the most important pathological mechanisms which could aggravate ischemic stroke injury. In order to seek for better treatment therapies to alleviate stroke injury, novel chemicals have been synthetized. In the present study, a new compound 4-((5-(tert-butyl)-3-chloro-2-hydroxybenzyl) amino)-2- hydroxybenzoic acid, named LX009, was used to determine whether it could reduce the oxidative stress caused by oxygen-glucose deprivation (OGD)/reperfusion (RP) and exert neuroprotective effect both in mouse Neuro 2A (N2A) neuroblastoma cells and mouse primary cortical neurons...
April 30, 2018: Life Sciences
https://www.readbyqxmd.com/read/29722298/acupuncture-and-neuroregeneration-in-ischemic-stroke
#12
REVIEW
Qwang-Yuen Chang, Yi-Wen Lin, Ching-Liang Hsieh
Acupuncture is potentially beneficial for post-stroke rehabilitation and is considered a promising preventive strategy for stroke. Electroacupuncture pretreatment or treatment after ischemic stroke by using appropriate electroacupuncture parameters generates neuroprotective and neuroregenerative effects that increase cerebral blood flow, regulate oxidative stress, attenuate glutamate excitotoxicity, maintain blood-brain barrier integrity, inhibit apoptosis, increase growth factor production, and induce cerebral ischemic tolerance...
April 2018: Neural Regeneration Research
https://www.readbyqxmd.com/read/29720501/bilirubin-is-inversely-associated-with-cardiovascular-disease-among-hiv-positive-and-hiv-negative-individuals-in-vacs-veterans-aging-cohort-study
#13
Vincent C Marconi, Meredith S Duncan, Kaku So-Armah, Vincent Lo Re, Joseph K Lim, Adeel A Butt, Matthew Bidwell Goetz, Maria C Rodriguez-Barradas, Charles W Alcorn, Jeffrey Lennox, Joshua A Beckman, Amy Justice, Matthew Freiberg
BACKGROUND: Bilirubin may protect against cardiovascular disease (CVD) by reducing oxidative stress. Whether elevated bilirubin reduces the risk of CVD events among HIV+ individuals and if this differs from uninfected individuals remain unclear. We assessed whether bilirubin independently predicted the risk of CVD events among HIV+ and uninfected participants in VACS (Veterans Aging Cohort Study). METHODS AND RESULTS: We conducted a prospective cohort study using VACS participants free of baseline CVD...
May 2, 2018: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29719841/pre-treatment-with-metformin-in-comparison-with-post-treatment-reduces-cerebral-ischemia-reperfusion-induced-injuries-in-rats
#14
Mojtaba Karimipour, Sara Shojaei Zarghani, Majid Mohajer Milani, Hamid Soraya
Objective: To explore the effects of pre versus post ischemic treatment with metformin after global cerebral ischemia in rats. Methods: Male Wister rats underwent forebrain ischemia by bilateral common carotid artery occlusion for 17 min. Metformin (200 mg/kg) or vehicle was given orally by gavage for 7-14 days. Rats were divided into: control, metformin pre-treatment, metformin post-treatment and metformin pre and post continuous treatment groups. Cerebral infarct size, histopathology, myeloperoxidase and serum malondialdehyde were measured 7 days after ischemia...
April 2018: Bulletin of Emergency and Trauma
https://www.readbyqxmd.com/read/29710464/cistanche-deserticola-polysaccharides-protects-pc12-cells-against-ogd-rp-induced-injury
#15
Yue Liu, Hui Wang, Mei Yang, Ning Liu, Yuping Zhao, Xue Qi, Yang Niu, Tao Sun, Yuxiang Li, Jianqiang Yu
Ischemia stroke is a disease with high morbidity and mortality. Cistanche deserticola polysaccharides (CDP) possess a wide range of beneficial effects, including hepatoprotection and immune homeostasis. As far as we know, the protective effect of CDP on neurons injured by oxygen-glucose deprivation/reperfusion (OGD/RP) has not been investigated. In this study, OGD/RP injured a PC12 cell model. Briefly, CDP (0.05, 0.5 and 5??g/ml) was administered before reperfusion. The protective effect of CDP was then evaluated on the basis of cell viability, lactate dehydrogenase (LDH) leakage, [Ca2+ ]i , mitochondrial membrane potential (MMP)and cell apoptosis, and redox status after reperfusion was evaluated by assaying reactive oxygen species (ROS), catalase (CAT), glutathione peroxidase (GSH-Px) and total antioxidant capacity...
March 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29708005/microrna-based-therapeutics-in-central-nervous-system-injuries
#16
Ping Sun, Da Zhi Liu, Glen C Jickling, Frank R Sharp, Ke-Jie Yin
Central nervous system (CNS) injuries, such as stroke, traumatic brain injury (TBI) and spinal cord injury (SCI), are important causes of death and long-term disability worldwide. MicroRNA (miRNA), small non-coding RNA molecules that negatively regulate gene expression, can serve as diagnostic biomarkers and are emerging as novel therapeutic targets for CNS injuries. MiRNA-based therapeutics include miRNA mimics and inhibitors (antagomiRs) to respectively decrease and increase the expression of target genes...
January 1, 2018: Journal of Cerebral Blood Flow and Metabolism
https://www.readbyqxmd.com/read/29700768/proteomic-analysis-of-cerebral-cortex-extracts-from-sus-scrofa-with-induced-hemorrhagic-stroke
#17
Alexander A Sidyakin, Anna L Kaysheva, Artur T Kopylov, Alexander V Lobanov, Sergei G Morozov
Cerebrovascular diseases, including stroke and micro stroke, are the main causes of death in contemporary society. Hemorrhagic stroke is the fast emerging defficiency in the brain function resulting from disturbance of blood supply to the brain caused by the rapture of blood vessels (Lopez et al. in Proteomics Clin Appl 6:190-200, 2012). The influence of a model hemorrhagic stroke on white pigs with the change in the protein profile of their cortical samples 24 h and 2 months after the stroke was examined using mass-spectrometric analysis...
April 26, 2018: Journal of Molecular Neuroscience: MN
https://www.readbyqxmd.com/read/29697839/brain-derived-erythropoietin-protects-from-intermittent-hypoxia-induced-cardiorespiratory-dysfunction-and-oxidative-stress-in-mice
#18
Elizabeth Elliot-Portal, Sofien Laouafa, Christian Arias-Reyes, Tara Adele Janes, Vincent Joseph, Jorge Soliz
Study Objectives: Based on the fact that erythropoietin (Epo) administration in rodents protects against spatial learning and cognitive deficits induced by chronic intermittent hypoxia (CIH)-mediated oxidative damage, here we tested the hypothesis that Epo in the brain protects against cardiorespiratory disorders and oxidative stress induced by CIH in adult mice. Methods: Adult control and transgenic mice overexpressing Epo in the brain only (Tg21) were exposed to CIH (21%-10% O2-10 cycles/hour-8 hours/day-7 days) or room air...
April 25, 2018: Sleep
https://www.readbyqxmd.com/read/29688134/genistein-attenuates-brain-damage-induced-by-transient-cerebral-ischemia-through-up-regulation-of-nrf2-expression-in-ovariectomized-rats
#19
Zhong-Yan Miao, Xu Xia, Lu Che, Yan-Tao Song
OBJECTIVE: Postmenopausal women possess higher incidence of stroke and worse prognosis. Although estrogen replacement therapy has obvious neuroprotective effects against stroke, it is always accompanied with several adverse effects and undesired outcomes. Genistein, a natural phytoestrogen, has been indicated to be a potential neuroprotective alternative for postmenopausal women against stroke. However, the role and mechanism of genistein's neuroprotective effects against stroke in ovariectomized rats have rarely been explored...
April 24, 2018: Neurological Research
https://www.readbyqxmd.com/read/29686642/efficacy-of-novel-carbon-nanoparticle-antioxidant-therapy-in-a-severe-model-of-reversible-middle-cerebral-artery-stroke-in-acutely-hyperglycemic-rats
#20
Roderic H Fabian, Paul J Derry, Harriett Charmaine Rea, William V Dalmeida, Lizanne G Nilewski, William K A Sikkema, Pitchaiah Mandava, Ah-Lim Tsai, Kimberly Mendoza, Vladimir Berka, James M Tour, Thomas A Kent
Introduction: While oxidative stress can be measured during transient cerebral ischemia, antioxidant therapies for ischemic stroke have been clinically unsuccessful. Many antioxidants are limited in their range and/or capacity for quenching radicals and can generate toxic intermediates overwhelming depleted endogenous protection. We developed a new antioxidant class, 40 nm × 2 nm carbon nanoparticles, hydrophilic carbon clusters, conjugated to poly(ethylene glycol) termed PEG-HCCs...
2018: Frontiers in Neurology
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