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Oxidative stress,inflammation,atherosclerosis,stroke

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https://www.readbyqxmd.com/read/27766082/exercise-does-not-protect-against-peripheral-and-central-effects-of-a-high-cholesterol-diet-given-ad-libitum-in-old-apoe-mice
#1
Vanessa Di Cataldo, Alain Géloën, Jean-Baptiste Langlois, Fabien Chauveau, Benoît Thézé, Violaine Hubert, Marlène Wiart, Erica N Chirico, Jennifer Rieusset, Hubert Vidal, Vincent Pialoux, Emmanuelle Canet-Soulas
Aim: Advanced atherosclerosis increases inflammation and stroke risk in the cerebral vasculature. Exercise is known to improve cardio-metabolic profiles when associated with a caloric restriction, but it remains debated whether it is still beneficial without the dietary control. The aim of this study was to determine both the peripheral and central effects of exercise training combined with a cholesterol-rich diet given ad libitum in old ApoE(-/-) mice. Methods: Forty-five-weeks old obese ApoE(-/-) mice fed with a high cholesterol diet ad libitum were divided into Exercise-trained (EX; running wheel free access) and Sedentary (SED) groups...
2016: Frontiers in Physiology
https://www.readbyqxmd.com/read/27066292/circulating-endothelial-microparticles-a-key-hallmark-of-atherosclerosis-progression
#2
REVIEW
Keshav Raj Paudel, Nisha Panth, Dong-Wook Kim
The levels of circulating microparticles (MPs) are raised in various cardiovascular diseases. Their increased level in plasma is regarded as a biomarker of alteration in vascular function. The prominent MPs present in blood are endothelial microparticles (EMPs) described as complex submicron (0.1 to 1.0 μm) vesicles like structure, released in response to endothelium cell activation or apoptosis. EMPs possess both physiological and pathological effects and may promote oxidative stress and vascular inflammation...
2016: Scientifica
https://www.readbyqxmd.com/read/27004027/better-prognosis-in-overweight-obese-coronary-heart-disease-patients-with-high-plasma-levels-of-leptin
#3
Luminita Animarie Vida Simiti, Irina Todor, Mirela Anca Stoia, Cerasela Mihaela Goidescu, Florin Petru Anton, Anca Daniela Farcas
BACKGROUND AND AIM: The involvement of leptin in atherosclerosis is very complex, including inflammation, the oxidative stress and thrombosis. Leptin has atherogenic and also antiatherogenic actions. In obesity elevated leptin levels are not sufficient to prevent disturbances of energy balance, suggesting that obese people are leptin resistant. The aim of the study was to investigate the relationship between baseline plasma levels of leptin and the incidence of new ischemic events in patients with CHD...
2016: Clujul Medical (1957)
https://www.readbyqxmd.com/read/26904258/air-particulate-matter-and-cardiovascular-disease-the-epidemiological-biomedical-and-clinical-evidence
#4
REVIEW
Yixing Du, Xiaohan Xu, Ming Chu, Yan Guo, Junhong Wang
Air pollution is now becoming an independent risk factor for cardiovascular morbidity and mortality. Numerous epidemiological, biomedical and clinical studies indicate that ambient particulate matter (PM) in air pollution is strongly associated with increased cardiovascular disease such as myocardial infarction (MI), cardiac arrhythmias, ischemic stroke, vascular dysfunction, hypertension and atherosclerosis. The molecular mechanisms for PM-caused cardiovascular disease include directly toxicity to cardiovascular system or indirectly injury by inducing systemic inflammation and oxidative stress in peripheral circulation...
January 2016: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/26878282/the-association-of-urinary-polycyclic-aromatic-hydrocarbon-biomarkers-and-cardiovascular-disease-in-the-us-population
#5
Omayma Alshaarawy, Hosam A Elbaz, Michael E Andrew
BACKGROUND: Polycyclic aromatic hydrocarbons (PAHs) are potent atmospheric pollutants produced by incomplete combustion of organic materials. Pre-clinical and occupational studies have reported a positive association of PAHs with oxidative stress, inflammation and subsequent development of atherosclerosis, a major underlying risk factor for cardiovascular disease (CVD). The aim of the current study is to estimate the association between levels of PAH biomarkers and CVD in a national representative sample of United States (US) adults...
April 2016: Environment International
https://www.readbyqxmd.com/read/26605517/severity-of-coronary-atherosclerosis-in-patients-with-copd
#6
Neşe Dursunoglu, Dursun Dursunoglu, Ali İhsan Yıldız, Burcu Uludag, Zahide Namlı Alaçam, Ahmet Sarıçopur
OBJECTIVES: Chronic obstructive pulmonary disease (COPD) has many comorbidities such as coronary artery disease (CAD) and stroke. Chronic low-grade systemic inflammation and oxidative stress play a significant role in CAD and COPD. We analysed that impact of COPD on intensity and severity of coronary artery lesions on the angiogram in the groups of patients with COPD according to the Global Initiative for Obstructive Lung Disease (GOLD) grades updated in 2015. METHODS: The study included 102 COPD patients and 80 randomly selected subjects without any pulmonary disease who underwent coronary angiography...
November 25, 2015: Clinical Respiratory Journal
https://www.readbyqxmd.com/read/26542505/soluble-receptor-for-advanced-glycation-end-products-and-the-risk-for-incident-heart-failure-the-atherosclerosis-risk-in-communities-study
#7
MULTICENTER STUDY
Mariana Lazo, Marc K Halushka, Lu Shen, Nisa Maruthur, Casey M Rebholz, Andreea M Rawlings, Ron C Hoogeveen, Tina E Brinkley, Christie M Ballantyne, Brad C Astor, Elizabeth Selvin
BACKGROUND: Experimental studies in animals suggest that circulating soluble receptor for advanced glycation end products (sRAGE) decrease oxidative stress, inflammation, and fibrosis. The association between sRAGE and incident heart failure has not been systematically examined in a prospective study. METHODS: We conducted a prospective analysis of a subsample of 1,086 participants from the Atherosclerosis Risk in Communities Study who attended visit 2 (1990-1992) without a history of coronary heart disease, stroke, or heart failure and with measured plasma sRAGE levels...
November 2015: American Heart Journal
https://www.readbyqxmd.com/read/26510435/the-role-of-nadph-oxidase-in-vascular-disease-hypertension-atherosclerosis-stroke
#8
REVIEW
Stephen P Gray, Karin A M Jandeleit-Dahm
The family of NADPH oxidase (Nox) proteins plays an integral role in the homeostatic functions of the cell, including gene expression, cell migration, proliferation, senescence and inflammation. There are currently 4 isoforms (Nox1, 2, 4 and 5) that are expressed across all cell types of the vascular system and play an important role in many physiological processes such as endothelial function, vascular tone and angiogenesis. The balance between Nox derived reactive oxygen species production and their elimination by dismutase enzymes is a critical finely tuned process...
2015: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/26441842/mineralocorticoid-receptors-in-the-pathophysiology-of-vascular-inflammation-and-atherosclerosis
#9
REVIEW
Mary E Moss, Iris Z Jaffe
Atherosclerosis is a chronic inflammatory disease of the vasculature that causes significant morbidity and mortality from myocardial infarction, stroke, and peripheral vascular disease. Landmark clinical trials revealed that mineralocorticoid receptor (MR) antagonists improve outcomes in cardiovascular patients. Conversely, enhanced MR activation by the hormone aldosterone is associated with increased risk of MI, stroke, and cardiovascular death. This review summarizes recent advances in our understanding of the role of aldosterone and the MR in the pathogenesis of vascular inflammation and atherosclerosis as it proceeds from risk factor-induced endothelial dysfunction and inflammation to plaque formation, progression, and ultimately rupture with thrombosis, the cause of acute ischemia...
2015: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/26322175/inflammation-oxidative-stress-and-renin-angiotensin-system-in-atherosclerosis
#10
REVIEW
Kazim Husain, Wilfredo Hernandez, Rais A Ansari, Leon Ferder
Atherosclerosis is a chronic inflammatory disease associated with cardiovascular dysfunction including myocardial infarction, unstable angina, sudden cardiac death, stroke and peripheral thromboses. It has been predicted that atherosclerosis will be the primary cause of death in the world by 2020. Atherogenesis is initiated by endothelial injury due to oxidative stress associated with cardiovascular risk factors including diabetes mellitus, hypertension, cigarette smoking, dyslipidemia, obesity, and metabolic syndrome...
August 26, 2015: World Journal of Biological Chemistry
https://www.readbyqxmd.com/read/26277384/resveratrol-neuroprotection-in-stroke-and-traumatic-cns-injury
#11
REVIEW
Mary S Lopez, Robert J Dempsey, Raghu Vemuganti
Resveratrol, a stilbene formed in many plants in response to various stressors, elicits multiple beneficial effects in vertebrates. Particularly, resveratrol was shown to have therapeutic properties in cancer, atherosclerosis and neurodegeneration. Resveratrol-induced benefits are modulated by multiple synergistic pathways that control oxidative stress, inflammation and cell death. Despite the lack of a definitive mechanism, both in vivo and in vitro studies suggest that resveratrol can induce a neuroprotective state when administered acutely or prior to experimental injury to the CNS...
October 2015: Neurochemistry International
https://www.readbyqxmd.com/read/26033474/angiopoietin-like-4-a-double-edged-sword-in-atherosclerosis-and-ischemic-stroke
#12
Liang Xu, Zhen-Ni Guo, Yi Yang, Jun Xu, Sherrefa R Burchell, Jiping Tang, Jianmin Zhang, Jing Xu, John H Zhang
Ischemic stroke is one of the leading causes of death in the world, and thus is a major public health concern. Atherosclerosis, also known as atherogenesis, is a crucial risk factor for cerebral ischemia, yet how it develops remains largely unknown. It has been found, however, that angiopoietin-like protein 4 (ANGPTL4), a protein expressed in vascular endothelial cells, plays a role in the pathophysiology of atherosclerosis and may therefore be involved in ischemic stroke. ANGPTL4 activity is associated with endothelial cell integrity, inflammation, oxidative stress, and lipid metabolism...
October 2015: Experimental Neurology
https://www.readbyqxmd.com/read/26016451/oxidative-stress-and-paraoxonase-1-status-in-acute-ischemic-stroke-patients
#13
Jelena Kotur-Stevuljevic, Natasa Bogavac-Stanojevic, Zorana Jelic-Ivanovic, Aleksandra Stefanovic, Tamara Gojkovic, Jelena Joksic, Miron Sopic, Brankica Gulan, Jelena Janac, Sanja Milosevic
OBJECTIVE: The connection of oxidative stress with dyslipidemia creates a newly-emerging atherosclerosis risk factor involved in acute ischemic stroke development. This study analyzed the influence of oxidative stress on structural changes of high-density lipoprotein (HDL) particles connected with modification in protective paraoxonase 1 (PON1) activity. METHODS: This study used 185 patients with acute ischemic stroke and 185 apparently healthy controls. Oxidative stress status, PON1 status, lipids and high-sensitivity C-reactive protein (hsCRP) were determined...
July 2015: Atherosclerosis
https://www.readbyqxmd.com/read/25987425/the-renin-angiotensin-system-and-its-involvement-in-vascular-disease
#14
REVIEW
Bibi S van Thiel, Ingrid van der Pluijm, Luuk te Riet, Jeroen Essers, A H Jan Danser
The renin-angiotensin system (RAS) plays a critical role in the pathogenesis of many types of cardiovascular diseases including cardiomyopathy, valvular heart disease, aneurysms, stroke, coronary artery disease and vascular injury. Besides the classical regulatory effects on blood pressure and sodium homoeostasis, the RAS is involved in the regulation of contractility and remodelling of the vessel wall. Numerous studies have shown beneficial effect of inhibition of this system in the pathogenesis of cardiovascular diseases...
September 15, 2015: European Journal of Pharmacology
https://www.readbyqxmd.com/read/25940230/benefits-of-the-mediterranean-diet-insights-from-the-predimed-study
#15
REVIEW
Miguel A Martínez-González, Jordi Salas-Salvadó, Ramón Estruch, Dolores Corella, Montse Fitó, Emilio Ros
The PREDIMED (PREvención con DIeta MEDiterránea) multicenter, randomized, primary prevention trial assessed the long-term effects of the Mediterranean diet (MeDiet) on clinical events of cardiovascular disease (CVD). We randomized 7447 men and women at high CVD risk into three diets: MeDiet supplemented with extra-virgin olive oil (EVOO), MeDiet supplemented with nuts, and control diet (advice on a low-fat diet). No energy restriction and no special intervention on physical activity were applied. We observed 288 CVD events (a composite of myocardial infarction, stroke or CVD death) during a median time of 4...
July 2015: Progress in Cardiovascular Diseases
https://www.readbyqxmd.com/read/25631392/aging-exacerbates-pressure-induced-mitochondrial-oxidative-stress-in-mouse-cerebral-arteries
#16
Zsolt Springo, Stefano Tarantini, Peter Toth, Zsuzsanna Tucsek, Akos Koller, William E Sonntag, Anna Csiszar, Zoltan Ungvari
Epidemiological studies demonstrate that in addition to the increased prevalence of hypertension in old patients, the deleterious cerebrovascular effects of hypertension (including atherosclerosis, stroke, and vascular cognitive impairment) are also exacerbated in elderly individuals. The cellular mechanisms by which aging and hypertension interact to promote cerebrovascular pathologies are not well understood. To test the hypothesis that aging exacerbates high pressure-induced mitochondrial oxidative stress, we exposed isolated segments of the middle cerebral arteries of young (3 months) and aged (24 months) C57BL/6 mice to 60 or 140 mmHg intraluminal pressure and assessed changes in mitochondrial reactive oxygen species production using a mitochondria-targeted redox-sensitive fluorescent indicator dye (MitoSox) by confocal microscopy...
November 2015: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/25515699/contribution-of-neovascularization-and-intraplaque-haemorrhage-to-atherosclerotic-plaque-progression-and-instability
#17
REVIEW
D A Chistiakov, A N Orekhov, Y V Bobryshev
Atherosclerosis is a continuous pathological process that starts early in life and progresses frequently to unstable plaques. Plaque rupture leads to deleterious consequences such as acute coronary syndrome, stroke and atherothrombosis. The vulnerable lesion has several structural and functional hallmarks that distinguish it from the stable plaque. The unstable plaque has large necrotic core (over 40% plaque volume) composed of cholesterol crystals, cholesterol esters, oxidized lipids, fibrin, erythrocytes and their remnants (haeme, iron, haemoglobin), and dying macrophages...
March 2015: Acta Physiologica
https://www.readbyqxmd.com/read/25483717/naringenin-and-atherosclerosis-a-review-of-literature
#18
REVIEW
Ilkay E Orhan, Seyed F Nabavi, Maria Daglia, Gian C Tenore, Kowsar Mansouri, Seyed M Nabavi
Atherosclerosis is a multifactorial disease mainly caused by deposition of low-density lipoprotein (LD) cholesterol in macrophages of arterial walls. Atherosclerosis leads to heart attacks as well as stroke. Epidemiological studies showed that there is an inverse correlation between fruit and vegetable consumption and the risk of atherosclerosis. The promising effect of high vegetable and fruit containing diet on atherosclerosis is approved by several experimental studies on isolated phytochemicals such as flavonoids...
2015: Current Pharmaceutical Biotechnology
https://www.readbyqxmd.com/read/25174928/smoking-and-atherosclerosis-mechanisms-of-disease-and-new-therapeutic-approaches
#19
REVIEW
Gerasimos Siasos, Vasiliki Tsigkou, Eleni Kokkou, Evangelos Oikonomou, Manolis Vavuranakis, Charalambos Vlachopoulos, Alexis Verveniotis, Maria Limperi, Vasiliki Genimata, Athanasios G Papavassiliou, Christodoulos Stefanadis, Dimitris Tousoulis
It has been clear that at least 1 billion adults worldwide are smokers and at least 700 million children are passive smokers at home. Smoking exerts a detrimental effect to many organ systems and is responsible for illnesses such as lung cancer, pneumonia, chronic obstructive pulmonary disease, cancer of head and neck, cancer of the urinary and gastrointestinal tract, periodontal disease, cataract and arthritis. Additionally, smoking is an important modifiable risk factor for the development of cardiovascular disease such as coronary artery disease, stable angina, acute coronary syndromes, sudden death, stroke, peripheral vascular disease, congestive heart failure, erectile dysfunction and aortic aneurysms via initiation and progression of atherosclerosis...
2014: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/25036262/cardiovascular-mortality-how-can-it-be-prevented
#20
Ramón Estruch
The first step in the prevention and treatment of many chronic diseases such as cardiovascular diseases is to follow a healthy diet. Several epidemiological studies have observed that following a traditional Mediterranean diet reduces overall and cardiovascular mortality, as well as the incidence of chronic diseases such as cardiovascular diseases, cancer and neurodegenerative diseases. However, up to now, only one study has analysed the effects of the Mediterranean diet on the primary prevention of cardiovascular disease, the PREDIMED (PREvención con DIeta MEDiterránea) study...
2014: Nefrología: Publicación Oficial de la Sociedad Española Nefrologia
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