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Oxidative stress, atherosclerosis,inflammation

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https://www.readbyqxmd.com/read/29341349/peroxiredoxin-4-prdx4-its-critical-in-vivo-roles-in-animal-models-of-metabolic-syndrome-ranging-from-atherosclerosis-to-nonalcoholic-fatty-liver-disease
#1
REVIEW
Sohsuke Yamada, Xin Guo
The peroxiredoxin (PRDX) family, a new family of proteins with a pivotal antioxidative function, is ubiquitously synthesized and abundantly identified in various organisms. In contrast to the intracellular localization of other family members (PRDX1/2/3/5/6), PRDX4 is the only known secretory form and protects against oxidative damage by scavenging reactive oxygen species in both the intracellular (especially the endoplasmic reticulum) compartments and the extracellular space. We generated unique human PRDX4 (hPRDX4) transgenic (Tg) mice on a C57BL/6J background and investigated the critical and diverse protective roles of PRDX4 against diabetes mellitus, atherosclerosis, insulin resistance, and nonalcoholic fatty liver disease (NAFLD) as well as evaluated its role in the intestinal function in various animal models...
January 17, 2018: Pathology International
https://www.readbyqxmd.com/read/29325849/coagonist-of-glp-1-and-glucagon-decreases-liver-inflammation-and-atherosclerosis-in-dyslipidemic-condition
#2
Vishal Patel, Amit Joharapurkar, Samadhan Kshirsagar, Brijesh Sutariya, Maulik Patel, Dhreerendra Pandey, Hiren Patel, Ramchandra Ranvir, Shekhar Kadam, Dipam Patel, Rajesh Bahekar, Mukul Jain
Dyslipidemia enhances progression of atherosclerosis. Coagonist of GLP-1 and glucagon are under clinical investigation for the treatment of obesity and diabetes. Earlier, we have observed that coagonist reduced circulating and hepatic lipids, independent of its anorexic effects. Here, we investigated the role of coagonist of GLP-1 and glucagon receptors in complications of diet-induced dyslipidemia in hamsters and humanized double transgenic mice. Hamsters fed on high fat high cholesterol diet were treated for 8 weeks with coagonist of GLP-1 and glucagon receptors (75 and 150 μg/kg)...
January 8, 2018: Chemico-biological Interactions
https://www.readbyqxmd.com/read/29323716/oxidative-burden-in-familial-hypercholesterolemia
#3
REVIEW
Hamid Mollazadeh, Federico Carbone, Fabrizio Montecucco, Matteo Pirro, Amirhossein Sahebkar
Familial hypercholesterolemia (FH) is a genetic disorder characterized by high serum levels of low-density lipoprotein cholesterol (LDL-c). FH is characterized by accelerated development of atherosclerosis and represents the most frequent hereditary cause of premature coronary heart disease. Mutations of the LDL receptor gene are the genetic signature of FH, resulting in abnormal levels of circulating LDLs. Moreover, FH promotes the generation of reactive oxygen species (ROS) which is another key mechanism involved in atherosclerosis development and progression...
January 11, 2018: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29301530/understanding-amd-by-analogy-systematic-review-of-lipid-related-common-pathogenic-mechanisms-in-amd-ad-as-and-gn
#4
REVIEW
Qinyuan Xu, Sijia Cao, Sanjeeva Rajapakse, Joanne A Matsubara
RATIONALE: Age-related macular degeneration (AMD) is one of the leading causes of blindness among the elderly. Due to its complex etiology, current treatments have been insufficient. Previous studies reveal three systems closely involved in AMD pathogenesis: lipid metabolism, oxidation and inflammation. These systems are also involved in Alzheimer's disease, atherosclerosis and glomerulonephritis. Understanding commonalities of these four diseases may provide insight into AMD etiology...
January 4, 2018: Lipids in Health and Disease
https://www.readbyqxmd.com/read/29260581/dietary-phenolic-acids-reverse-insulin-resistance-hyperglycaemia-dyslipidaemia-inflammation-and-oxidative-stress-in-high-fructose-diet-induced-metabolic-syndrome-rats
#5
Oluwayemisi B Ibitoye, Taofeek O Ajiboye
This study investigated the influence of caffeic, ferulic, gallic and protocatechuic acids on high-fructose diet-induced metabolic syndrome in rats. Oral administration of the phenolic acids significantly reversed high-fructose diet-mediated increase in body mass index and blood glucose. Furthermore, phenolic acids restored high-fructose diet-mediated alterations in metabolic hormones (insulin, leptin and adiponectin). Similarly, elevated tumour necrosis factor-α, interleukin-6 and -8 were significantly lowered...
December 20, 2017: Archives of Physiology and Biochemistry
https://www.readbyqxmd.com/read/29259496/immunosenescence-in-aging-between-immune-cells-depletion-and-cytokines-up-regulation
#6
REVIEW
Maria Teresa Ventura, Marco Casciaro, Sebastiano Gangemi, Rosalba Buquicchio
Background: The immunosenescence is a relatively recent chapter, correlated with the linear extension of the average life began in the nineteenth century and still in progress. The most important feature of immunosenescence is the accumulation in the "immunological space" of memory and effector cells as a result of the stimulation caused by repeated clinical and subclinical infections and by continuous exposure to antigens (inhalant allergens, food, etc.). This state of chronic inflammation that characterizes senescence has a significant impact on survival and fragility...
2017: Clinical and Molecular Allergy: CMA
https://www.readbyqxmd.com/read/29227739/chronic-exposure-to-external-low-dose-gamma-radiation-induces-an-increase-in-anti-inflammatory-and-anti-oxidative-parameters-resulting-in-atherosclerotic-plaque-size-reduction-in-apoe-mice
#7
T G Ebrahimian, L Beugnies, J Surette, N Priest, Y Gueguen, C Gloaguen, M Benderitter, J R Jourdain, K Tack
Populations living in radiation-contaminated territories, such as Chernobyl and Fukushima, are chronically exposed to external gamma radiation and internal radionuclide contamination due to the large amount of 137Cs released in the environment. The effect of chronic low-dose exposure on the development of cardiovascular diseases remains unclear. Previously reported studies have shown that low-dose radiation exposure could lead to discrepancies according to dose rate. In this study, we examined the effect of very low-dose and dose-rate chronic external exposure on atherosclerosis development...
December 11, 2017: Radiation Research
https://www.readbyqxmd.com/read/29226948/mir-182-5p-inhibited-oxidative-stress-and-apoptosis-triggered-by-oxidized-low-density-lipoprotein-via-targeting-toll-like-receptor-4
#8
Song-Bai Qin, Da-Yan Peng, Yan Shi, Zun-Ping Ke
MicroRNAs (miRNAs) exhibit various roles in multiple biological processes and abnormal expression of miR-182-5p has been involved in many diseases. However, the role miR-182-5p in Atherosclerosis (AS) remains poorly understood. In our current investigation, an AS model was established by using oxidized low-density lipoprotein (ox-LDL) in RAW264.7 cells. miR-182-5p was markedly decreased in AS model dose-dependently and time-dependently. Additionally, CD36, oil-red staining levels, TC and TG were inhibited by miR-182-5p mimics, meanwhile ROS levels, MDA and cell apoptosis were also restrained with an enhancement of SOD activity...
December 11, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29220092/dose-rectification-of-an-unbalance-between-dpp4-and-glp-1-ameliorates-chronic-stress-related-vascular-aging-and-atherosclerosis
#9
Xian Wu Cheng, Megumi Narisawa, Enze Jin, Chenglin Yu, Wenhu Xu, Limei Piao
Exposure to psychosocial stress is a risk factor for cardiovascular disease, including vascular aging and regeneration. Dipeptidyl peptidase-4 (DPP-4) exerts many physiological and pharmacological functions by regulating its extremely abundant substrates [e.g., glucagon-like peptide-1 (GLP-1), stromal cell-derived factor-1α/ C-X-C chemokine receptor type-4, etc.]. Over the past decade, emerging data revealed unexpected roles for DPP-4 and GLP-1 in intracellular signaling, oxidative stress production, lipid metabolism, cell apoptosis, immune activation, insulin resistance, and inflammation...
December 8, 2017: Clinical and Experimental Pharmacology & Physiology
https://www.readbyqxmd.com/read/29215758/plin5-deficiency-promotes-atherosclerosis-progression-through-accelerating-inflammation-apoptosis-and-oxidative-stress
#10
Peng-Li Zhou, Min Li, Xin-Wei Han, Yong-Hua Bi, Wen-Guang Zhang, Zheng-Yang Wu, Gang Wu
Excessive plasma triglyceride and cholesterol levels promote the progression of several prevalent cardiovascular risk factors, including atherosclerosis, which is a leading death cause. Perilipin 5 (Plin5), an important perilipin protein, is abundant in tissues with very active lipid catabolism, and is involved in the regulation of oxidative stress. Although, in?ammation and oxidative stress play a critical role in atherosclerosis development, the underlying mechanisms are complex and not completely understood...
December 7, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29210129/effect-of-resveratrol-and-pterostilbene-on-aging-and-longevity
#11
REVIEW
Yi-Rong Li, Shiming Li, Chi-Chien Lin
Over the past years, several studies have found that foods rich in polyphenols protect against age-related disease, such as atherosclerosis, cardiovascular disease, cancer, arthritis, cataracts, osteoporosis, type 2 diabetes (T2D), hypertension and Alzheimer's disease. Resveratrol and pterostilbene, the polyphenol found in grape and blueberries, have beneficial effects as anti-aging compounds through modulating the hallmarks of aging, including oxidative damage, inflammation, telomere attrition and cell senescence...
December 6, 2017: BioFactors
https://www.readbyqxmd.com/read/29207167/prazosin-protects-myocardial-cells-against-anoxia-reoxygenation-injury-via-the-extracellular-signal%C3%A2-regulated-kinase-signaling-pathway
#12
Lixin Wang, Yan Xue, Hao Ma, Haiyan Shi, Ling Wang, Xiaozheng Cui
Ischemic heart disease (including coronary arterial atherosclerosis, or vascular cavity stenosis or occlusion) remains the leading cause of disease‑associated mortality worldwide. Prazosin, a receptor blocker of postsynaptic adrenaline, is essential in expanding peripheral arteries, which decreases peripheral vascular resistance, and regulates anti‑hypertensive action. However, the mechanisms underlying the effects of prazosin have not been fully elucidated. The aim of the present study was to investigate the protective effects of prazosin on myocardial cells against anoxia‑reoxygenation injury in a mouse model...
November 28, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29196930/association-of-alox12-gene-polymorphism-with-all-cause-and-cardiovascular-mortality-in-diabetic-nephropathy
#13
Athanasios K Roumeliotis, Stefanos K Roumeliotis, Stylianos A Panagoutsos, Fotis Tsetsos, Marianthi Georgitsi, Vangelis Manolopoulos, Peristera Paschou, Ploumis S Passadakis
PURPOSE: Cardiovascular (CV) events are the first cause of death in patients with chronic renal disease (CKD) and in patients with type 2 diabetes mellitus (DM2). The combination of CKD and DM2 elevates the risk of both cardiovascular disease (CVD) and death in this high-risk population. Besides traditional risk factors, such as dyslipidemia, smoking, obesity, and carotid atherosclerosis, novel factors are under investigation such as genetic polymorphisms. Lipoxygenases (LOXs) and their genes are of critical importance in oxidative stress, inflammation, and atherosclerosis...
December 1, 2017: International Urology and Nephrology
https://www.readbyqxmd.com/read/29195136/oxidized-ldl-triggers-changes-in-oxidative-stress-and-inflammatory-biomarkers-in-human-macrophages
#14
Oscar J Lara-Guzmán, Ángel Gil-Izquierdo, Sonia Medina, Edison Osorio, Rafael Álvarez-Quintero, Natalia Zuluaga, Camille Oger, Jean-Marie Galano, Thierry Durand, Katalina Muñoz-Durango
Oxidized low-density lipoprotein (oxLDL) is a well-recognized proatherogenic particle that functions in atherosclerosis. In this study, we established conditions to generate human oxLDL, characterized according to the grade of lipid and protein oxidation, particle size and oxylipin content. The induction effect of the cellular proatherogenic response was assessed in foam cells by using an oxLDL-macrophage interaction model. Uptake of oxLDL, reactive oxygen species production and expression of oxLDL receptors (CD36, SR-A and LOX-1) were significantly increased in THP-1 macrophages...
November 22, 2017: Redox Biology
https://www.readbyqxmd.com/read/29187192/comprehensive-metabolic-profiling-of-chronic-low-grade-inflammation-among-generally-healthy-individuals
#15
Maik Pietzner, Anne Kaul, Ann-Kristin Henning, Gabi Kastenmüller, Anna Artati, Markus M Lerch, Jerzy Adamski, Matthias Nauck, Nele Friedrich
BACKGROUND: Inflammation occurs as an immediate protective response of the immune system to a harmful stimulus, whether locally confined or systemic. In contrast, a persisting, i.e., chronic, inflammatory state, even at a low-grade, is a well-known risk factor in the development of common diseases like diabetes or atherosclerosis. In clinical practice, laboratory markers like high-sensitivity C-reactive protein (hsCRP), white blood cell count (WBC), and fibrinogen, are used to reveal inflammatory processes...
November 30, 2017: BMC Medicine
https://www.readbyqxmd.com/read/29175647/gamma-glutamyl-transferase-and-the-risk-of-atherosclerosis-and-coronary-heart-disease
#16
REVIEW
Gjin Ndrepepa, Roisin Colleran, Adnan Kastrati
Gamma-glutamyl transferase (GGT) is a ubiquitous cell surface enzyme that cleaves extracellular glutathione (G-SH) or other gamma-glutamyl compounds. GGT serves to increase the availability of amino acids, primarily cysteine, for intracellular G-SH synthesis and plays a crucial role in maintaining G-SH homeostasis and defense against oxidative stress in organisms. Measurement of circulating GGT activity is widely used for the diagnosis of liver and obstructive biliary diseases and as an indicator of alcohol consumption...
November 23, 2017: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/29167617/statin-attenuated-myocardial-inflammation-induced-by-pm2-5-in-rats
#17
Hongmei Yao, Jiyuan Lv
Background: Here, the study aims to explore the effect of PM2.5 exposure on atherosclerosis in rats. Materials and Methods: 32 Wistar rats were selected in our study. An atherosclerosis model was established. All rats were evenly divided into four groups, including normal control group (NC), model control group (MC), model PM2.5 group (PM2.5) and model Atorvastatin group (Atorvastatin). The rats in NC and model control group were treated with saline 1 ml/kg body weight by tail intravenous injection, while the rats in PM2...
November 2017: Acta Cardiologica Sinica
https://www.readbyqxmd.com/read/29167167/cellular-mechanisms-underlying-obesity-induced-arterial-stiffness
#18
Annayya R Aroor, Guanghong Jia, James R Sowers
Obesity is an emerging pandemic driven by consumption of a diet rich in high fat and high refined carbohydrates (western diet [WD]) and a sedentary life style in both children and adults. There is mounting evidence that arterial stiffness in obesity is an independent and strong predictor of adverse cardiovascular disease (CVD), cognitive functional decline and chronic kidney disease. Cardiovascular stiffness is a precursor to systolic hypertension, cardiac diastolic dysfunction, impairment of coronary and cerebral blood flow, and atherosclerosis...
November 22, 2017: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
https://www.readbyqxmd.com/read/29163665/chlorinative-stress-in-age-related-diseases-a-literature-review
#19
REVIEW
Marco Casciaro, Eleonora Di Salvo, Elisabetta Pace, Elvira Ventura-Spagnolo, Michele Navarra, Sebastiano Gangemi
Aging is an agglomerate of biological long-lasting processes that result being inevitable. Main actors in this scenario are both long-term inflammation and oxidative stress. It has been proved that oxidative stress induce alteration in proteins and this fact itself is critically important in the pathophysiological mechanisms leading to diseases typical of aging. Among reactive species, chlorine ones such as hypochlorous acid (HOCl) are cytotoxic oxidants produced by activated neutrophils during chronic inflammation processes...
2017: Immunity & Ageing: I & A
https://www.readbyqxmd.com/read/29156574/infectious-agents-in-atherosclerotic-cardiovascular-diseases-through-oxidative-stress
#20
REVIEW
Marisa Di Pietro, Simone Filardo, Francesca Falasca, Ombretta Turriziani, Rosa Sessa
Accumulating evidence demonstrates that vascular oxidative stress is a critical feature of atherosclerotic process, potentially triggered by several infectious agents that are considered as risk co-factors for the atherosclerotic cardiovascular diseases (CVDs). C. pneumoniae has been shown to upregulate multiple enzymatic systems capable of producing reactive oxygen species (ROS) such as NADPH oxidase (NOX) and cyclooxygenase in vascular endothelial cells, NOX and cytochrome c oxidase in macrophages as well as nitric oxide synthase and lipoxygenase in platelets contributing to both early and late stages of atherosclerosis...
November 18, 2017: International Journal of Molecular Sciences
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