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https://www.readbyqxmd.com/read/29677538/improvement-effects-of-a-mixed-extract-of-flowers-of-pueraria-thomsonii-benth-and-peels-of-citrus-unshiu-markovich-on-postmenopausal-symptoms-of-ovariectomized-mice
#1
Na-Ra Han, Sun-Young Nam, Sungwei Hong, Hee-Yun Kim, Phil-Dong Moon, Hyeong-Jin Kim, Hosong Cho, Boyoung Lee, Hyung-Min Kim, Hyun-Ja Jeong
BACKGROUND: Menopausal hot flushes occur frequently in postmenopausal women. In the present study, we investigated a regulatory effect of a mixed extract of flowers of Pueraria thomsonii Benth. and peels of Citrus unshiu Markovich (PCE17), an extract of flowers of Pueraria thomsonii Benth. (PE), an extract of peels of Citrus unshiu Markovich (CE), a mixture of tectorigenin 7-O-xylosylglucoside, tectoridin, and tectorigenin (Tec, the active compounds of PE), and hesperidin (Hes, an active compound of CE) on menopausal hot flushes...
April 17, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29676796/sympathetic-control-of-cardiac-output-by-norepinephrine-quasi-synaptic-quantal-release-or-interstitial-diffusion-and-spill-over
#2
Philipp Sasse
No abstract text is available yet for this article.
April 20, 2018: Journal of Physiology
https://www.readbyqxmd.com/read/29675711/%C3%AE-2-adrenoceptor-signaling-reduction-is-involved-in-the-inflammatory-response-of-fibroblast-like-synoviocytes-from-adjuvant-induced-arthritic-rats
#3
Huaxun Wu, Jingyu Chen, Chun Wang, Lihua Liu, Yujing Wu, Yunfang Zhang, Aiwu Zhou, Lingling Zhang, Wei Wei
OBJECTIVE: To investigate the effects of β-AR signaling on fibroblast-like synoviocytes (FLS) from adjuvant-induced arthritis (AA) rats and the partial mechanisms focused on β-AR desensitization mediated by GRK2 and β-arrestin2. METHODS: Animals were divided into a control group and an AA model group, and FLSs were cultured. Arthritis index, histopathology of joints, epinephrine (Epi) and norepinephrine (NE) were detected in vivo. The effect of the β-AR agonist isoprenaline (ISO) and the β2 -AR agonist salbutamol on FLS cell viability were detected by CCK8...
April 19, 2018: Inflammopharmacology
https://www.readbyqxmd.com/read/29675424/erratum-to-contribution-of-ca-2-dependent-cl-channels-to-norepinephrine-induced-contraction-of-femoral-artery-is-replaced-by-increasing-edcf-contribution-during-ageing
#4
Silvia Liskova, Miriam Petrova, Petr Karen, Michal Behuliak, Josef Zicha
[This corrects the article DOI: 10.1155/2014/289361.].
2018: BioMed Research International
https://www.readbyqxmd.com/read/29674777/-la-diagnostic-clinical-interview-for-drug-withdrawal-1-did-w1-new-symptoms-of-selective-serotonin-reuptake-inhibitors-ssri-or-serotonin-norepinephrine-reuptake-inhibitors-snri-affidabilit%C3%A3-fra-valutatori
#5
Fiammetta Cosci, Guy Chouinard, Virginie-Anne Chouinard, Giovanni Andrea Fava
RIASSUNTO. Scopo. Dopo la riduzione della dose o la sospensione di Selective Serotonin Reuptake Inhibitors (SSRI) o di Serotonin Norepinephrine Reuptake Inhibitors (SNRI) si possono verificare molti fenomeni clinici. Nel 2015, è stata delineata una nuova classificazione delle sindromi d'astinenza da SSRI/SNRI (cioè, nuovi sintomi, rimbalzo, disturbi persistenti post-astinenza) sulla base della letteratura e delle osservazioni cliniche. Un'intervista clinica semistrutturata, la Diagnostic clinical Interview for Drug Withdrawal 1 - New Symptoms of SSRI and SNRI (DID-W1), è stata sviluppata allo scopo di identificare e differenziare queste sindromi...
March 2018: Rivista di Psichiatria
https://www.readbyqxmd.com/read/29674241/protective-effect-of-betulinic-acid-against-intracerebroventricular-streptozotocin-induced-cognitive-impairment-and-neuronal-damage-in-rats-possible-neurotransmitters-and-neuroinflammatory-mechanism
#6
Madhu Kaundal, Rahul Deshmukh, Mohd Akhtar
BACKGROUND: The purpose of the study was to explore the therapeutic potential of Betulinic acid (BA) in streptozotocin (STZ) induced memory damage in experimental rats. METHODS: STZ (3 mg/kg bilaterally) as intracerebroventrical (icv) route was administered on day 1 and 3 in rats. Donepezil (5 mg/kg/day po), used as standard, and BA (5, 10 and 15 mg/kg/day po) were administered after 1 h of 1st STZ infusion up to 21 days. Object recognition task (ORT) for non-spatial, Morris water maze (MWM) for spatial and locomotor activity were performed to evaluate behavioral changes in rats...
December 6, 2017: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/29673396/measurement-of-plasma-norepinephrine-and-3-4-dihydroxyphenylglycol-method-development-for-a-translational-research-study
#7
Quin E Denfeld, Beth A Habecker, William R Woodward
OBJECTIVE: Norepinephrine (NE), a sympathetic neurotransmitter, is often measured in plasma as an index of sympathetic activity. To better understand NE dynamics, it is important to measure its principal metabolite, 3,4-dihydroxyphenylglycol (DHPG), concurrently. Our aim was to present a method, developed in the course of a translational research study, to measure NE and DHPG in human plasma using high performance liquid chromatography with electrochemical detection (HPLC-ED). RESULTS: After pre-purifying plasma samples by alumina extraction, we used HPLC-ED to separate and quantify NE and DHPG...
April 19, 2018: BMC Research Notes
https://www.readbyqxmd.com/read/29673366/improving-cytocompatibility-of-cdte-quantum-dots-by-schiff-base-coordinated-lanthanides-surface-doping
#8
Hana Buchtelova, Vladislav Strmiska, Zuzana Skubalova, Simona Dostalova, Petr Michalek, Sona Krizkova, David Hynek, Lukas Kalina, Lukas Richtera, Amitava Moulick, Vojtech Adam, Zbynek Heger
BACKGROUND: Suitable fluorophores are the core of fluorescence imaging. Among the most exciting, yet controversial, labels are quantum dots (QDs) with their unique optical and chemical properties, but also considerable toxicity. This hinders QDs applicability in living systems. Surface chemistry has a profound impact on biological behavior of QDs. This study describes a two-step synthesis of QDs formed by CdTe core doped with Schiff base ligand for lanthanides [Ln (Yb3+ , Tb3+ and Gd3+ )] as novel cytocompatible fluorophores...
April 19, 2018: Journal of Nanobiotechnology
https://www.readbyqxmd.com/read/29673128/synthesis-analytical-characterization-and-monoamine-transporter-activity-of-the-new-psychoactive-substance-4-methylphenmetrazine-4-mpm-with-differentiation-from-its-ortho-and-meta-positional-isomers
#9
Gavin McLaughlin, Michael H Baumann, Pierce V Kavanagh, Noreen Morris, John D Power, Geraldine Dowling, Brendan Twamley, John O'Brien, Gary Hessman, Folker Westphal, Donna Walther, Simon D Brandt
The availability of new psychoactive substances on the recreational drug market continues to create challenges for scientists in the forensic, clinical and toxicology fields. Phenmetrazine (3-methyl-2-phenylmorpholine) and an array of its analogs form a class of psychostimulants that are well documented in the patent and scientific literature. The present study reports on two phenmetrazine analogs that have been encountered on the NPS drug market following the introduction of 3-fluorophenmetrazine (3-FPM), namely 4-methylphenmetrazine (4-MPM) and 3-methylphenmetrazine (3-MPM)...
April 19, 2018: Drug Testing and Analysis
https://www.readbyqxmd.com/read/29671235/evaluation-of-neurotransmitter-alterations-in-four-distinct-brain-regions-after-rapid-eye-movement-sleep-deprivation-remsd-induced-mania-like-behaviour-in-swiss-albino-mice
#10
Saiful Alom Siddique, Thangavel Tamilselvan, Manikkannan Vishnupriya, Elumalai Balamurugan
A number of neurotransmitter systems have been implicated in contributing to the pathology of mood disorders, including those of dopamine (DA), serotonin (5-HT), norepinephrine (NE) and γ-aminobutyric acid (GABA). Rapid eye movement sleep deprivation (REMSD) alters most of the neurotransmitters, which may have adverse behavioural changes and other health consequences like mania and other psychiatric disorders. The exact role of REMSD altered neurotransmitter levels and the manner in which emerging consequences lead to mania-like behaviour is poorly understood...
April 18, 2018: Neurochemical Research
https://www.readbyqxmd.com/read/29670821/amphetamine-but-not-methylphenidate-increases-ethanol-intake-in-adolescent-male-but-not-in-female-rats
#11
Paul Ruiz, Aldo Calliari, Patricia Genovese, Cecilia Scorza, Ricardo Marcos Pautassi
Introduction: There has been an increasing interest in analyzing the interactions between stimulants and ethanol during childhood and adolescence. Stimulants are used to treat attention-deficit hyperactivity disorder (ADHD) in these developmental stages, during which ethanol initiation and escalation often occur. Methods: This study assessed the effects of repeated d-amphetamine (AMPH) or methylphenidate (MPH) treatment during adolescence [male and female Wistar rats, between postnatal day (PD) 28 to PD34, approximately] on the initiation of ethanol intake during a later section of adolescence (PD35 to PD40)...
April 2018: Brain and Behavior
https://www.readbyqxmd.com/read/29670504/clozapine-induced-cardiovascular-side-effects-and-autonomic-dysfunction-a-systematic-review
#12
Jessica W Y Yuen, David D Kim, Ric M Procyshyn, Randall F White, William G Honer, Alasdair M Barr
Background: Clozapine is the antipsychotic of choice for treatment-resistant schizophrenia and has minimal risk for extrapyramidal symptoms. Therapeutic benefits, however, are accompanied by a myriad of cardiometabolic side-effects. The specific reasons for clozapine's high propensity to cause adverse cardiometabolic events remain unknown, but it is believed that autonomic dysfunction may play a role in many of these. Objective: This systematic review summarizes the literature on autonomic dysfunction and related cardiovascular side effects associated with clozapine treatment...
2018: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/29668843/effects-of-catecholamines-on-secretion-of-interferon-tau-and-expression-of-genes-for-synthesis-of-polyamines-and-apoptosis-by-ovine-trophectoderm
#13
Mohammed A Elmetwally, Yasser Lenis, Wanjin Tang, Guoyao Wu, Fuller W Bazer
Ovine trophectoderm (oTr1) cells were used to investigate effects of epinephrine (EP), norepinephrine (NE) and dopamine (DA) on their proliferation, migration and adhesion, secretion of interferon tau (IFNT), and expression of genes for synthesis of polyamines and apoptosis. Expression of mRNAs for agmatinase (AGMAT), arginine decarboxylase (ADC), ornithine decarboxylase (ODC1) and solute carrier family 7 (SLC7A1) cationic amino acid transporter, Y + system), member 1 increased (P < 0.05) in oTr1 cells in response to EP and DA...
April 12, 2018: Biology of Reproduction
https://www.readbyqxmd.com/read/29668606/terlipressin-in-the-treatment-of-hepatorenal-syndrome-a-systematic-review-and-meta-analysis
#14
Haiqing Wang, Aixiang Liu, Wentao Bo, Xielin Feng, Yong Hu
BACKGROUND: Hepatorenal syndrome is a fatal complication of advanced cirrhosis. Terlipressin is the most widely used treatment method, however, the therapy effects remain inconsonant. We aim to systematically assess the safety and efficacy of terlipressin for hepatorenal syndrome. METHODS: We conducted a systematic review and meta-analysis. Randomized controlled trials involving terlipressin for hepatorenal syndrome were included in a systematic literature search...
April 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29668464/effects-of-%C3%AE-prazosin-and-yohimbine-and-%C3%AE-receptors-activity-on-camp-generation-and-ucp1-gene-expression-in-brown-adipocytes
#15
Hirendra M Biswas
BACKGROUND: Brown adipose tissue (BAT) contains both α- and β-adrenergic receptors. In the literature, the activity of α-adrenoreceptors is less documented, and their functions still remain puzzling. The present investigation has been undertaken to understand α-adrenoreceptors' activity and their relation between uncoupling protein 1 (UCP1) mRNA expression and cyclic AMP (cAMP) generation in BAT. METHODS: BAT precursor cells from young mice were grown in culture...
April 18, 2018: Journal of Basic and Clinical Physiology and Pharmacology
https://www.readbyqxmd.com/read/29668082/altered-stress-hormone-response-following-acute-exercise-during-prostate-cancer-treatment
#16
Erik D Hanson, Samy Sakkal, William S Evans, John A Violet, Claudio L Battaglini, Glenn K McConell, Alan Hayes
Exercise training reduces the side effects of cancer treatments, however, the stress hormone response to acute exercise during prostate cancer (PCa) treatment is unclear. PURPOSE: To examine the effects of acute exercise on circulating cortisol, epinephrine (Epi), and norepinephrine (NE) concentrations during PCa treatment with and without androgen deprivation therapy (ADT). METHODS: Men with PCa (n=11), with PCa on ADT (n=11) and non-cancer controls (n=8) had blood samples for stress hormones collected before and immediately (0h), 2h, and 24h after 45 minutes of intermittent cycling at 60% of peak wattage...
April 18, 2018: Scandinavian Journal of Medicine & Science in Sports
https://www.readbyqxmd.com/read/29667909/losartan-does-not-decrease-renal-oxygenation-and-norepinephrine-effects-in-rats-after-resuscitated-haemorrhage
#17
Sofia Jönsson, Jacqueline M Melville, Mediha Becirovic-Agic, Michael Hultström
Renin-angiotensin-system blockers are thought to increase the risk of acute kidney injury after surgery and haemorrhage. We found that Losartan does not cause renal cortical hypoxia after haemorrhage in rats because of decreased renal vascular resistance, but did not evaluate resuscitation. AIM: Study Losartan´s effect on renal cortical and medullary oxygenation, and norepinephrine´s vasopressor effect in a model of resuscitated haemorrhage. METHOD: After seven days Losartan (60 mg/kg/day) or control treatment, male Wistar rats were haemorrhaged 20 % of the blood volume and resuscitated with Ringer's Acetate...
April 18, 2018: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/29666153/the-ins-and-outs-of-vesicular-monoamine-transporters
#18
REVIEW
Dana Yaffe, Lucy R Forrest, Shimon Schuldiner
The H+ -coupled vesicular monoamine transporter (VMAT) is a transporter essential for life. VMAT mediates packaging of the monoamines serotonin, dopamine, norepinephrine, and histamine from the neuronal cytoplasm into presynaptic vesicles, which is a key step in the regulated release of neurotransmitters. However, a detailed understanding of the mechanism of VMAT function has been limited by the lack of availability of high-resolution structural data. In recent years, a series of studies guided by homology models has revealed significant insights into VMAT function, identifying residues that contribute to the binding site and to specific steps in the transport cycle...
April 17, 2018: Journal of General Physiology
https://www.readbyqxmd.com/read/29662268/a-pediatric-case-of-pheochromocytoma-without-apparent-hypertension-associated-with-von-hippel-lindau-disease
#19
Junko Igaki, Akira Nishi, Takeshi Sato, Tomonobu Hasegawa
Pheochromocytomas are catecholamine-secreting tumors. These tumors are rare in children, and they may be associated with hereditary syndromes such as von Hippel-Lindau (VHL) disease. Most pediatric patients with pheochromocytoma present with sustained hypertension, while 10% to 69% of adult patients are asymptomatic. Herein, we present the case of a 12-yr-old Japanese girl with pheochromocytoma due to a germline mutation in the VHL (Arg161Gln). The only complaint was loss of weight. Pyrexia, anemia, and increases in C-reactive protein (CRP) and ferritin were observed...
2018: Clinical Pediatric Endocrinology: Case Reports and Clinical Investigations: Official Journal of the Japanese Society for Pediatric Endocrinology
https://www.readbyqxmd.com/read/29661830/sustained-adrenergic-signaling-promotes-intratumoral-innervation-through-bdnf-induction
#20
Julie K Allen, Guillermo N Armaiz-Pena, Archana S Nagaraja, Nouara C Sadaoui, Tatiana Ortiz, Robert Dood, Merve Ozcan, Danielle M Herder, Monika Haemerrle, Kshipra M Gharpure, Rajesha Rupaimoole, Rebecca Previs, Sherry Y Wu, Sunila Pradeep, Xiaoyun Xu, Hee Dong Han, Behrouz Zand, Heather J Dalton, Morgan Taylor, Wei Hu, Justin Bottsford-Miller, Myrthala Moreno-Smith, Yu Kang, Lingegowda S Mangala, Cristian Rodriguez-Aguayo, Vasudha Sehgal, Erika L Spaeth, Prahlad T Ram, Stephen Tc Wong, Frank C Marini, Gabriel Lopez-Berestein, Steve W Cole, Susan K Lutgendorf, Mariella diBiasi, Anil K Sood
Mounting clinical and preclinical evidence supports a key role for sustained adrenergic signaling in the tumor microenvironment as a driver of tumor growth and progression. However, the mechanisms by which adrenergic neurotransmitters are delivered to the tumor microenvironment are not well understood. Here we present evidence for a feedforward loop whereby adrenergic signaling leads to increased tumoral innervation. In response to catecholamines, tumor cells produced brain-derived neurotrophic factor (BDNF) in an ADRB3/cAMP/Epac/JNK-dependent manner...
April 16, 2018: Cancer Research
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