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https://www.readbyqxmd.com/read/28805359/medicare-program-prospective-payment-system-and-consolidated-billing-for-skilled-nursing-facilities-for-fy-2018-snf-value-based-purchasing-program-snf-quality-reporting-program-survey-team-composition-and-correction-of-the-performance-period-for-the-nhsn-hcp
#1
(no author information available yet)
This final rule updates the payment rates used under the prospective payment system (PPS) for skilled nursing facilities (SNFs) for fiscal year (FY) 2018. It also revises and rebases the market basket index by updating the base year from 2010 to 2014, and by adding a new cost category for Installation, Maintenance, and Repair Services. The rule also finalizes revisions to the SNF Quality Reporting Program (QRP), including measure and standardized resident assessment data policies and policies related to public display...
August 4, 2017: Federal Register
https://www.readbyqxmd.com/read/28793846/health-literacy-and-written-communication-in-skilled-nursing-subacute-facilities
#2
Christopher Galati, Rachel Adams, Kay Graham, Katharyn Reynolds, Julia Zametin
Health literacy is a concern for older adults. Low health literacy can lead to adverse health outcomes; therefore, practitioners should address health literacy with clients. There is limited research addressing occupational therapy (OT) practitioners' knowledge of health literacy and its implementation in written communication in skilled nursing facility (SNF)/subacute settings. Researchers explored practitioners' knowledge and current practices when using written communication with older adult clients in skilled nursing and subacute settings...
August 1, 2017: OTJR: Occupation, Participation and Health
https://www.readbyqxmd.com/read/28783755/snrk1-activates-autophagy-via-the-tor-signaling-pathway-in-arabidopsis-thaliana
#3
Junmarie Soto-Burgos, Diane C Bassham
Autophagy is a degradation process in which cells break down and recycle their cytoplasmic contents when subjected to environmental stress or during cellular remodeling. The Arabidopsis thaliana SnRK1 complex is a protein kinase that senses changes in energy levels and triggers downstream responses to enable survival. Its mammalian ortholog, AMPK, and yeast ortholog, Snf-1, activate autophagy in response to low energy conditions. We therefore hypothesized that SnRK1 may play a role in the regulation of autophagy in response to nutrient or energy deficiency in Arabidopsis...
2017: PloS One
https://www.readbyqxmd.com/read/28782593/the-subsequent-course-of-disability-in-older-persons-discharged-to-a-skilled-nursing-facility-after-an-acute-hospitalization
#4
Zuyun Liu, Ling Han, Linda Leo-Summers, Evelyne A Gahbauer, Heather G Allore, Thomas M Gill
OBJECTIVES: To evaluate the association between the type of acute hospitalization and subsequent course of disability in older persons discharged to a skilled nursing facility (SNF). DESIGN: Longitudinal study of 754 community-living persons aged 70 or older. PARTICIPANTS: The analytical sample included 365 participants who had one or more admissions to a SNF after an acute hospitalization (n=520 index admissions). MEASUREMENTS: Information on hospitalizations, SNF admissions, and disability was ascertained over 15years...
August 4, 2017: Experimental Gerontology
https://www.readbyqxmd.com/read/28768829/the-saga-complex-together-with-transcription-factors-and-the-endocytic-protein-rvs167p-coordinate-the-reprofiling-of-gene-expression-in-response-to-changes-in-sterol-composition-in-saccharomyces-cerevisiae
#5
Gisèle Dewhurst-Maridor, Daniel Abegg, Fabrice P A David, Jacques Rougemont, Cameron C Scott, Alexander Adibekian, Howard Riezman
Changes in cellular sterol species and concentrations can have profound effects on the transcriptional profile. In yeast, mutants defective in sterol biosynthesis show a wide range of changes in transcription, including a co-induction of anaerobic genes and ergosterol biosynthesis genes, biosynthesis of basic amino acids, and several stress genes. However the mechanisms underlying these changes are unknown. We identified mutations in the SAGA complex, a co-activator of transcription, which abrogate the ability to carry out most of these sterol-dependent transcriptional changes...
August 2, 2017: Molecular Biology of the Cell
https://www.readbyqxmd.com/read/28767641/iswi-chromatin-remodellers-sense-nucleosome-modifications-to-determine-substrate-preference
#6
Geoffrey P Dann, Glen Liszczak, John D Bagert, Manuel M Müller, Uyen T T Nguyen, Felix Wojcik, Zachary Z Brown, Jeffrey Bos, Tatyana Panchenko, Rasmus Pihl, Samuel B Pollock, Katharine L Diehl, C David Allis, Tom W Muir
ATP-dependent chromatin remodelers regulate access to genetic information by controlling nucleosome positions in vivo(1). However, the mechanism by which remodelers discriminate between different nucleosome substrates is poorly understood. Considering that many chromatin remodeling proteins possess conserved protein domains that interact with nucleosomal features(2), we employed a quantitative high-throughput approach, based on the use of a DNA-barcoded mononucleosome library, to profile the biochemical activity of human ISWI remodelers in response to a diverse set of nucleosome modifications...
August 2, 2017: Nature
https://www.readbyqxmd.com/read/28762548/health-literacy-cognition-and-urinary-incontinence-among-geriatric-inpatients-discharged-to-skilled-nursing-facilities
#7
Joshua A Cohn, Avantika S Shah, Kathryn M Goggins, Sandra F Simmons, Sunil Kripalani, Roger R Dmochowski, John F Schnelle, William Stuart Reynolds
AIMS: To investigate the association between health literacy and cognition and nursing and patient-reported incontinence in a geriatric inpatient population transitioning to skilled nursing facilities (SNF). METHODS: Health literacy, depression, and cognition were assessed via the Brief Health Literacy Screen (BHLS), Geriatric Depression Scale 5-item (GDS) and Brief Interview for Mental Status (BIMS), respectively. Multivariable logistic regression assessed the association between BHLS score and incontinence by: (1) nursing-reported urinary incontinence during hospitalization; and (2) patient self-reported "bladder accidents" in the post-enrollment study interview...
August 1, 2017: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/28754838/the-chromatin-remodeling-bap-complex-limits-tumor-promoting-activity-of-the-hippo-pathway-effector-yki-to-prevent-neoplastic-transformation-in-drosophila-epithelia
#8
Shilin Song, Héctor Herranz, Stephen M Cohen
SWI/SNF chromatin remodeling complexes are mutated in many human cancers. In this report we make use of a Drosophila genetic model for epithelial tumor formation to explore the tumor suppressive role of SWI/SNF complex proteins. Members of the BAP complex exhibit tumor suppressor activity in tissue overexpressing the Yorkie (Yki) proto-oncogene, but not in tissue overexpressing EGFR. The BAP complex has been reported to serve as a Yki-binding cofactor to support Yki target expression. However, we observed that depletion of BAP leads to ectopic expression of Yki targets both autonomously and non-autonomously, suggesting additional indirect effects...
July 28, 2017: Disease Models & Mechanisms
https://www.readbyqxmd.com/read/28753627/nuclear-cytoplasmic-transport-defects-in-bbs6-underlie-congenital-heart-disease-through-perturbation-of-a-chromatin-remodeling-protein
#9
Charles Anthony Scott, Autumn N Marsden, Michael R Rebagliati, Qihong Zhang, Xitiz Chamling, Charles C Searby, Lisa M Baye, Val C Sheffield, Diane C Slusarski
Mutations in BBS6 cause two clinically distinct syndromes, Bardet-Biedl syndrome (BBS), a syndrome caused by defects in cilia transport and function, as well as McKusick-Kaufman syndrome, a genetic disorder characterized by congenital heart defects. Congenital heart defects are rare in BBS, and McKusick-Kaufman syndrome patients do not develop retinitis pigmentosa. Therefore, the McKusick-Kaufman syndrome allele may highlight cellular functions of BBS6 distinct from the presently understood functions in the cilia...
July 2017: PLoS Genetics
https://www.readbyqxmd.com/read/28749952/an-innovative-way-of-thinking-nuclear-waste-management-neutron-physics-of-a-reactor-directly-operating-on-snf
#10
Bruno Merk, Dzianis Litskevich, Mark Bankhead, Richard J Taylor
A solution for the nuclear waste problem is the key challenge for an extensive use of nuclear reactors as a major carbon free, sustainable, and applied highly reliable energy source. Partitioning and Transmutation (P&T) promises a solution for improved waste management. Current strategies rely on systems designed in the 60's for the massive production of plutonium. We propose an innovative strategic development plan based on invention and innovation described with the concept of developments in s-curves identifying the current boundary conditions, and the evolvable objectives...
2017: PloS One
https://www.readbyqxmd.com/read/28747241/developing-a-predictive-model-for-the-energy-content-of-goat-milk-as-the-basis-for-a-functional-unit-formulation-to-be-used-in-the-life-cycle-assessment-of-dairy-goat-production-systems
#11
P P Danieli, B Ronchi
Recent reports on livestock environmental impact based on life cycle assessment (LCA) did not fully consider the case of the dairy goat. Assignment of an environmental impact (e.g. global warming potential) to a specific product needs to be related to the appropriate 'unitary amount' or functional unit (FU). For milk, the energy content may provide a common basis for a definition of the FU. To date, no ad hoc formulations for the FU of goat milk have been proposed. For these reasons, this study aimed to develop and test one or more predictive models (DPMs) for the gross energy (GE) content of goat milk, based on published compositional data, such as fat (F), protein, total solids (TS), solid non-fat matter (SNF), lactose (Lac) and ash...
July 27, 2017: Animal: An International Journal of Animal Bioscience
https://www.readbyqxmd.com/read/28741798/novel-orally-bioavailable-ezh1-2-dual-inhibitors-with-greater-antitumor-efficacy-than-an-ezh2-selective-inhibitor
#12
Daisuke Honma, Osamu Kanno, Jun Watanabe, Junzo Kinoshita, Makoto Hirasawa, Emi Nosaka, Machiko Shiroishi, Takeshi Takizawa, Isao Yasumatsu, Takao Horiuchi, Akira Nakao, Keisuke Suzuki, Tomonori Yamasaki, Katsuyoshi Nakajima, Miho Hayakawa, Takanori Yamazaki, Ajay Singh Yadav, Nobuaki Adachi
Polycomb repressive complex 2 (PRC2) methylates histone H3 lysine 27 and represses gene expression to regulate cell proliferation and differentiation. Enhancer of zeste homolog 2 (EZH2) or its close homolog EZH1 functions as a catalytic subunit of PRC2, so there are two PRC2 complexes containing either EZH2 or EZH1. Tumorigenic functions of EZH2 and its synthetic lethality with some subunits of SWItch/Sucrose Non-Fermentable (SWI/SNF) chromatin remodeling complexes have been observed. However, little is known about the function of EZH1 in tumorigenesis...
July 25, 2017: Cancer Science
https://www.readbyqxmd.com/read/28739803/chromatin-remodeling-swi-snf-complex-regulates-coenzyme-q6-synthesis-and-a-metabolic-shift-to-respiration-in-yeast
#13
Agape M Awad, Srivats Venkataramanan, Anish Nag, Anoop Raj Galivanche, Michelle C Bradley, Lauren Neves, Stephen Douglass, Catherine F Clarke, Tracy L Johnson
Despite its relatively streamlined genome, there are many important examples of regulated RNA splicing in Saccharomyces cerevisiae Here we report a role for the chromatin remodeler SWI/SNF in respiration, partially via the regulation of splicing. We find that a nutrient-dependent decrease in Snf2 leads to an increase in splicing of the PTC7 transcript. The spliced PTC7 transcript encodes a mitochondrial phosphatase regulator of biosynthesis of coenzyme Q6 (ubiquinone, or CoQ6), a mitochondrial redox-active lipid essential for electron and proton transport in respiration, and increased splicing of PTC7 increases CoQ6 levels...
July 24, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28737768/arid1a-mutated-ovarian-cancers-depend-on-hdac6%C3%A2-activity
#14
Benjamin G Bitler, Shuai Wu, Pyoung Hwa Park, Yang Hai, Katherine M Aird, Yemin Wang, Yali Zhai, Andrew V Kossenkov, Ana Vara-Ailor, Frank J Rauscher Iii, Weiping Zou, David W Speicher, David G Huntsman, Jose R Conejo-Garcia, Kathleen R Cho, David W Christianson, Rugang Zhang
ARID1A, encoding a subunit of the SWI/SNF chromatin-remodelling complex, is the most frequently mutated epigenetic regulator across all human cancers. ARID1A and TP53 mutations are typically mutually exclusive. Therapeutic approaches that correlate with this genetic characteristic remain to be explored. Here, we show that HDAC6 activity is essential in ARID1A-mutated ovarian cancers. Inhibition of HDAC6 activity using a clinically applicable small-molecule inhibitor significantly improved the survival of mice bearing ARID1A-mutated tumours...
August 2017: Nature Cell Biology
https://www.readbyqxmd.com/read/28737171/brg1-swi-snf-dependent-regulation-of-the-wt1-transcriptional-landscape-mediates-epicardial-activity-during-heart-development-and-disease
#15
Joaquim Miguel Vieira, Sara Howard, Cristina Villa Del Campo, Sveva Bollini, Karina N Dubé, Megan Masters, Damien N Barnette, Mala Rohling, Xin Sun, Laura E Hankins, Daria Gavriouchkina, Ruth Williams, Daniel Metzger, Pierre Chambon, Tatjana Sauka-Spengler, Benjamin Davies, Paul R Riley
Epicardium-derived cells (EPDCs) contribute cardiovascular cell types during development and in adulthood respond to Thymosin β4 (Tβ4) and myocardial infarction (MI) by reactivating a fetal gene programme to promote neovascularization and cardiomyogenesis. The mechanism for epicardial gene (re-)activation remains elusive. Here we reveal that BRG1, the essential ATPase subunit of the SWI/SNF chromatin-remodelling complex, is required for expression of Wilms' tumour 1 (Wt1), fetal EPDC activation and subsequent differentiation into coronary smooth muscle, and restores Wt1 activity upon MI...
July 24, 2017: Nature Communications
https://www.readbyqxmd.com/read/28731166/screening-of-the-prognostic-targets-for-breast-cancer-based-co-expression-modules-analysis
#16
Huijuan Liu, Hui Ye
The purpose of the present study was to screen the prognostic targets for breast cancer based on a co-expression modules analysis. The microarray dataset GSE73383 was downloaded from the Gene Expression Omnibus (GEO) database, including 15 breast cancer samples with good prognosis and 9 breast cancer samples with poor prognosis. The differentially expressed genes (DEGs) were identified with the limma package. The Database for Annotation, Visualization and Integrated Discovery was used to perform Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis...
July 21, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28731042/molecular-alterations-of-coexisting-thyroid-papillary-carcinoma-and-anaplastic-carcinoma-identification-of-tert-mutation-as-an-independent-risk-factor-for-transformation
#17
Naoki Oishi, Tetsuo Kondo, Aya Ebina, Yukiko Sato, Junko Akaishi, Rumi Hino, Noriko Yamamoto, Kunio Mochizuki, Tadao Nakazawa, Hiroshi Yokomichi, Koichi Ito, Yuichi Ishikawa, Ryohei Katoh
Thyroid papillary carcinoma is the most common endocrine neoplasm and generally carries a favorable prognosis. However, a small subset of papillary carcinomas transforms into anaplastic carcinoma, an undifferentiated cancer with a dismal prognosis. Recent studies using next-generation sequencing revealed the genomic landscape of papillary carcinoma and anaplastic carcinoma. However, risk factors for anaplastic transformation in papillary carcinoma remain obscure. In the present study, we investigated molecular alterations of papillary carcinoma and anaplastic carcinoma components in 27 tumors in which anaplastic carcinoma coexisted with antecedent papillary carcinoma...
July 21, 2017: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://www.readbyqxmd.com/read/28728166/whole-genome-sequencing-revealed-novel-prognostic-biomarkers-and-promising-targets-for-therapy-of-ovarian-clear-cell-carcinoma
#18
Hiroaki Itamochi, Tetsuro Oishi, Nao Oumi, Satoshi Takeuchi, Kosuke Yoshihara, Mikio Mikami, Nobuo Yaegashi, Yasuhisa Terao, Kazuhiro Takehara, Kimio Ushijima, Hidemichi Watari, Daisuke Aoki, Tadashi Kimura, Toshiaki Nakamura, Yoshihito Yokoyama, Junzo Kigawa, Toru Sugiyama
BACKGROUND: Ovarian clear cell carcinoma (OCCC) is mostly resistant to standard chemotherapy that results in poor patient survival. To understand the genetic background of these tumours, we performed whole-genome sequencing of OCCC tumours. METHODS: Tumour tissue samples and matched blood samples were obtained from 55 Japanese women diagnosed with OCCC. Whole-genome sequencing was performed using the Illumina HiSeq platform according to standard protocols. RESULTS: Alterations to the switch/sucrose non-fermentable (SWI/SNF) subunit, the phosphatidylinositol-3-kinase (PI3K)/Akt signalling pathway, and the receptor tyrosine kinase (RTK)/Ras signalling pathway were found in 51%, 42%, and 29% of OCCC tumours, respectively...
July 20, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/28716950/analysis-of-small-critical-regions-of-swi1-conferring-prion-formation-maintenance-and-transmission
#19
Stephanie Valtierra, Zhiqiang Du, Liming Li
Saccharomyces cerevisiae contains several prion elements, which are epigenetically transmitted as self-perpetuating protein conformations. One such prion is [SWI(+) ], whose protein determinant is Swi1, a subunit of the SWI/SNF chromatin-remodeling complex. We previously reported that [SWI(+) ] formation results in a partial loss-of-function phenotype of poor growth in non-glucose media and abolishment of multicellularity. We also showed that the first 38 amino acids of Swi1 propagated [SWI(+)]. We show here that a region as small as the first 32 amino acids of Swi1 (Swi11-32) can decorate [SWI(+)] aggregation and stably maintain and transmit [SWI(+)] independently of full-length Swi1...
July 17, 2017: Molecular and Cellular Biology
https://www.readbyqxmd.com/read/28716731/arid1a-represses-hepatocellular-carcinoma-cell-proliferation-and-migration-through-lncrna-mvih
#20
Sheng Cheng, Lan Wang, Chuan-Huai Deng, Shi-Chun Du, Ze-Guang Han
ARID1A, encoding the BAF250a subunit of SWI/SNF complex, has a high mutation frequency in numerous types of cancer. LncRNAs, a type of non-coding RNAs longer than 200 nucleotides, have been reported to interplay with SWI/SNF complex during cancer progression. However, whether the interaction between ARID1A and lncRNA affects hepatocellular carcinoma (HCC) still needs to be investigated. Here, we reveal that ARID1A interacts with lncRNA MVIH through some region(s) or domain(s) including ARID domain and C-terminal ARID1A protein binding domain...
July 14, 2017: Biochemical and Biophysical Research Communications
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