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REVIEW
Silvia Casagrande, Luigi Zuliani, Wolfgang Grisold
The first reports of encephalitis associated with cancer date to the 1960s and were characterized by clinical and pathologic involvement of limbic areas. This specific association was called limbic encephalitis (LE). The subsequent discovery of several "onconeural" antibodies (Abs), i.e., Abs targeting an antigen shared by neurons and tumor cells, supported the hypothesis of an autoimmune paraneoplastic etiology of LE and other forms of rapidly progressive encephalopathy. Over the past 20 years, similar clinical pictures with different clinical courses have been described in association with novel Abs-binding neuronal membrane proteins and proved to be pathogenic...
2024: Handbook of Clinical Neurology
#2
MULTICENTER STUDY
Alberto Vogrig, Sara Tartaglia, Marta Dentoni, Martina Fabris, Francesco Bax, Marco Belluzzo, Lorenzo Verriello, Daniele Bagatto, Matteo Gastaldi, Pierluigi Tocco, Marco Zoccarato, Luigi Zuliani, Andrea Pilotto, Alessandro Padovani, Macarena Villagrán-García, Vincent Davy, Gian Luigi Gigli, Jérôme Honnorat, Mariarosaria Valente
BACKGROUND: COVID-19 vaccines have been approved due to their excellent safety and efficacy data and their use has also permitted to reduce neurological complications of SARS-CoV-2. However, clinical trials were underpowered to detect rare adverse events. Herein, the aim was to characterize the clinical spectrum and immunological features of central nervous system (CNS) immune-related events following SARS-CoV-2 vaccination. METHODS: Multicenter, retrospective, cohort study (December 1, 2020-April 30, 2022)...
2024: Frontiers in Immunology
#3
JOURNAL ARTICLE
Giulia Musso, Marco Zoccarato, Nicoletta Gallo, Andrea Padoan, Chiara Cosma, Luigi Zuliani, Piera De Gaspari, Elena Pegoraro, Mario Plebani, Daniela Basso
OBJECTIVES: Antibodies against glutamic acid decarboxylase isoform 65 (GAD-Ab) have been found in different severe neurological conditions associated with altered synthesis of γ-aminobutyric acid (GABA). Serum GAD-Ab can be found in up to 90 % of patients with Type 1 Diabetes mellitus (T1DM), mostly at relatively low concentrations, while high concentrations of GAD-ab are thought to be more frequently associate to a neurological condition, with levels 100-folds higher than those found in T1DM...
May 1, 2023: Clinical Chemistry and Laboratory Medicine: CCLM
#4
JOURNAL ARTICLE
Gianfranco De Stefano, Patrizia Pulitano, Carlo Di Bonaventura, Luigi Zuliani, Alessandra Morano
Here we describe the second ever-reported case of familial anti-leucine-rich glioma-inactivated protein 1 (LGI1) limbic encephalitis (LE). Two elderly Caucasian sisters presented with psychiatric symptoms and cognitive impairment, followed by faciobrachial dystonic seizures. Anti-LGI1 antibodies were detected in their serum. Considering they had been living in distant regions for decades, environmental factors could be ruled out. Human leukocyte antigen (HLA) genotyping revealed that both carried HLA-DRB1*07, found in 90% of anti-LGI1 encephalitis patients, HLA-DQA1*02:01 and HLA-DQB1*03:03, commonly associated with DRB1*07:01...
April 5, 2023: Journal of Neuroimmunology
#5
MULTICENTER STUDY
Margherita Nosadini, Michael Eyre, Thea Giacomini, Massimiliano Valeriani, Marida Della Corte, Andrea D Praticò, Pietro Annovazzi, Ramona Cordani, Duccio Maria Cordelli, Giovanni Crichiutti, Gabriella Di Rosa, Valentina Dolcemascolo, Anna Fetta, Elena Freri, Paolo Gallo, Matteo Gastaldi, Tiziana Granata, Luisa Grazian, Raffaele Iorio, Martina Lombardini, Monica Margoni, Sara Mariotto, Sara Matricardi, Federico Melani, Nardo Nardocci, Laura Papetti, Alice Passarini, Francesco Pisani, Chiara Po', Marco Puthenparampil, Francesca Ragona, Salvatore Savasta, Sabrina Siliquini, Irene Toldo, Alessandra Tozzo, Emanuela Claudia Turco, Antonio Varone, Alberto Vogrig, Luigi Zuliani, Samuela Bugin, Sara Rossato, Alessandro Orsini, Gaetano Cantalupo, Maria Margherita Mancardi, Michela Ada Noris Ferilli, Thomas Foiadelli, Stefano Sartori
BACKGROUND AND OBJECTIVES: We sought to identify early factors associated with relapse and outcome in paediatric-onset myelin oligodendrocyte glycoprotein antibody-associated disorders (MOGAD). METHODS: In a multicenter retrospective cohort of pediatric MOGAD (≤18 years), onset features and treatment were compared in patients with monophasic vs relapsing disease (including cases with follow-up ≥12 months after onset or relapse at any time) and in patients with final Expanded Disability Status Scale (EDSS) 0 vs ≥1 at last follow-up (including cases with follow-up >3 months after last event or EDSS0 at any time)...
January 2023: Neurology® Neuroimmunology & Neuroinflammation
#6
JOURNAL ARTICLE
Alessandra Morano, Emanuele Cerulli Irelli, Enrico Michele Salamone, Biagio Orlando, Martina Fanella, Emanuele Tinelli, Gabriele Ruffolo, Luigi Zuliani, Jinane Fattouch, Mario Manfredi, Anna Teresa Giallonardo, Carlo Di Bonaventura
INTRODUCTION: Late-onset epilepsy (LOE) has recently become a topic of intense research. Besides stroke, tumors, and dementia, autoimmune encephalitis (AE) has emerged as another possible cause of recurrent seizures in the elderly, and may account for a proportion of cases of LOE of unknown origin (LOEUO). This 24-h ambulatory electroencephalography (AEEG)-based study compared patients with LOEUO and AE to identify features suggestive of immune-mediated seizures in the elderly. MATERIALS AND METHODS: We retrospectively reviewed 232 AEEG examinations performed in patients over 55 years with ≥6-month follow-up, and selected 21 subjects with AE and 25 subjects with LOEUO...
2022: Frontiers in Neurology
#7
JOURNAL ARTICLE
Sara Matricardi, Sara Casciato, Silvia Bozzetti, Sara Mariotto, Andrea Stabile, Elena Freri, Francesco Deleo, Stefano Sartori, Margherita Nosadini, Irene Pappalardo, Stefano Meletti, Giada Giovannini, Elisabetta Zucchi, Carlo Di Bonaventura, Giancarlo Di Gennaro, Sergio Ferrari, Luigi Zuliani, Marco Zoccarato, Alberto Vogrig, Simona Lattanzi, Roberto Michelucci, Antonio Gambardella, Edoardo Ferlazzo, Lucia Fusco, Tiziana Granata, Flavio Villani
OBJECTIVE: To describe the clinical and paraclinical findings, treatment options and long-term outcomes in autoimmune encephalitis (AE), with a close look to epilepsy. METHODS: In this retrospective observational cohort study, we enrolled patients with new-onset seizures in the context of AE. We compared clinical and paraclinical findings in patients with and without evidence of antibodies. RESULTS: Overall, 263 patients (138 females; median age 55 years, range 4-86) were followed up for a median time of 30 months (range 12-120)...
July 25, 2022: Journal of Neurology, Neurosurgery, and Psychiatry
#8
JOURNAL ARTICLE
Marco Zuin, Antonio Cherubini, Stefano Volpato, Luigi Ferrucci, Giovanni Zuliani
We evaluated the effect of Acetyl-cholinesterase-inhibitors (AChEIs) on cognitive decline and overall survival in a large sample of older patients with late onset Alzheimer's disease (LOAD), vascular dementia (VD) or Lewy body disease (LBD) from a real world setting. Patients with dementia enrolled between 2005 and 2020 by the "Alzheimer's Disease Research Centers" were analysed; the mean follow-up period was 7.9 years. A 1:1 propensity score matching was performed generating a cohort of 1.572 patients (786 treated [AChEIs +] and 786 not treated [AChEIs-] with AChEIs...
July 16, 2022: Scientific Reports
#9
JOURNAL ARTICLE
Alessandra Morano, Emanuele Cerulli Irelli, Martina Fanella, Biagio Orlando, Enrico Michele Salamone, Emanuele Tinelli, Gabriele Ruffolo, Luigi Zuliani, Jinane Fattouch, Mario Manfredi, Anna Teresa Giallonardo, Carlo Di Bonaventura
BACKGROUND: Despite being long neglected, olfaction has recently become a focus of intense research in neuroscience, as smell impairment has been consistently documented in both neurodegenerative and neuroinflammatory diseases. Considering the close anatomo-functional correlations between the limbic system and the central olfactory structures, we investigated olfaction in a population of patients with autoimmune encephalitis (AE). METHODS: Nineteen adult subjects (14 males, median age 64 years) diagnosed with definite (14/19) or possible (5/19) AE and followed for ≥ 6 months were enrolled...
January 10, 2022: Journal of Neurology
#10
JOURNAL ARTICLE
Chiara Spigarelli, Marco Berton, Mirco Corazzin, Luigi Gallo, Sabine Pinterits, Maurizio Ramanzin, Wolfgang Ressi, Enrico Sturaro, Anna Zuliani, Stefano Bovolenta
The multidimensional concept of animal welfare includes physical health, good emotional state, and appropriate behavior of the animals. The most recent methods for its assessment are inspired by the Welfare Quality, a project compiling animal-, resource-, and management-based measures. Recently, animal welfare assessment has also considered the human factor in a so-called "One Welfare" approach. The One Welfare framework highlights the interconnections between animal welfare, human well-being, and the environment...
2021: Frontiers in Veterinary Science
#11
JOURNAL ARTICLE
Luigi Zuliani, Sabrina Marangoni, Piera De Gaspari, Irene Rosellini, Margherita Nosadini, Joanne M Fleming, Valentina De Riva, Elisabetta Galloni, Francesco Perini, Anna Chiara Frigo, Stefano Sartori, Marco Zoccarato, Bruno Giometto
Epidemiologic data on neuronal surface antibody (NSAb)-associated autoimmune encephalitides (NSAE) are scarce and heterogeneous. We review our 13-year-long biobank-data collection and provide the incidence of NSAE in two Italian provinces (approx. Population of 1,400,000) over a 5-year period (July 2013-June 2018). NSAbs were diagnosed in 75 out of 1179 tested patients (6.4%). The most common NSAbs were anti-LGI1 (30 cases), followed by NMDAR (24). Eleven cases of NSAE were diagnosed in Treviso and Trento provinces with an estimated incidence of 1...
August 15, 2021: Journal of Neuroimmunology
#12
MULTICENTER STUDY
Laura Andreoli, Cecilia Nalli, Maria Grazia Lazzaroni, Chiara Carini, Francesca Dall'Ara, Rossella Reggia, Marília Rodrigues, Carolina Benigno, Elena Baldissera, Elena Bartoloni, Fabio Basta, Francesca Bellisai, Alessandra Bortoluzzi, Corrado Campochiaro, Francesco Paolo Cantatore, Roberto Caporali, Angela Ceribelli, Cecilia B Chighizola, Paola Conigliaro, Addolorata Corrado, Maurizio Cutolo, Salvatore D'Angelo, Elena De Stefani, Andrea Doria, Maria Favaro, Colomba Fischetti, Rosario Foti, Armando Gabrielli, Elena Generali, Roberto Gerli, Maria Gerosa, Maddalena Larosa, Armin Maier, Nazzarena Malavolta, Marianna Meroni, Pier Luigi Meroni, Carlomaurizio Montecucco, Marta Mosca, Melissa Padovan, Giuseppe Paolazzi, Giulia Pazzola, Susanna Peccatori, Roberto Perricone, Giorgio Pettiti, Valentina Picerno, Immacolata Prevete, Véronique Ramoni, Nicoletta Romeo, Amelia Ruffatti, Carlo Salvarani, Gian Domenico Sebastiani, Carlo Selmi, Francesca Serale, Luigi Sinigaglia, Chiara Tani, Marica Trevisani, Marta Vadacca, Eleonora Valentini, Guido Valesini, Elisa Visalli, Ester Vivaldelli, Lucia Zuliani, Angela Tincani
The concern about the offspring's health is one of the reasons for a reduced family size of women with rheumatic diseases (RD). Increased risk of autoimmune diseases (AD) and neurodevelopmental disorders (ND) has been reported in children born to patients with RD. Within a nationwide survey about reproductive issues of women with RD, we aimed at exploring the long-term outcome of their children. By surveying 398 patients who received their diagnosis of RD during childbearing age (before the age of 45), information about the offspring were obtained from 230 women who declared to have had children...
April 2022: Clinical Reviews in Allergy & Immunology
#13
JOURNAL ARTICLE
Sebastiano Bucello, Pietro Annovazzi, Paolo Ragonese, Marta Altieri, Valeria Barcella, Roberto Bergamaschi, Alessia Bianchi, Giovanna Borriello, Maria Chiara Buscarinu, Graziella Callari, Marco Capobianco, Fioravante Capone, Paola Cavalla, Rosella Cavarretta, Antonio Cortese, Giovanna De Luca, Massimiliano Di Filippo, Vincenzo Dattola, Roberta Fantozzi, Elisabetta Ferraro, Maria Maddalena Filippi, Claudio Gasperini, Luigi Maria Edoardo Grimaldi, Doriana Landi, Marianna Lo Re, Giulia Mallucci, Paolo Manganotti, Girolama Alessandra Marfia, Massimiliano Mirabella, Paola Perini, Marco Pisa, Sabrina Realmuto, Margherita Russo, Valentina Tomassini, Valentina Liliana Adriana Torri-Clerici, Mauro Zaffaroni, Cristina Zuliani, Sofia Zywicki, Massimo Filippi, Luca Prosperini
OBJECTIVE: To identify baseline factors associated with disease activity in patients with relapsing-remitting multiple sclerosis (RRMS) under teriflunomide treatment. METHODS: This was an independent, multi-centre, retrospective post-marketing study. We analysed data of 1,507 patients who started teriflunomide since October 2014 and were regularly followed in 28 Centres in Italy. We reported the proportions of patients who discontinued treatment (after excluding 32 lost to follow-up) and who experienced clinical disease activity, i...
August 2021: Journal of Neurology
#14
JOURNAL ARTICLE
Serena Zuliani, Ilaria Zampiva, Daniela Tregnago, Miriam Casali, Alessandro Cavaliere, Arianna Fumagalli, Sara Merler, Silvia Teresa Riva, Alice Rossi, Francesca Zacchi, Elisa Zaninotto, Alessandra Auriemma, Michele Pavarana, Caterina Soldà, Lavinia Benini, Michele Borghesani, Alberto Caldart, Simona Casalino, Marina Gaule, Dzenete Kadrija, Marta Mongillo, Camilla Pesoni, Pamela Biondani, Sara Cingarlini, Elena Fiorio, Davide Melisi, Veronica Parolin, Luca Tondulli, Lorenzo Belluomini, Camilla Zecchetto, Barbara Avesani, Assunta Biasi, Chiara Bovo, Elena Dazzani, Alessandra Dodi, Sara Gelmini, Luigi Carmine Leta, Giuliana Lo Cascio, Fiorella Lombardo, Eleonora Lucin, Ilaria Asja Martinelli, Luisa Messineo, Viola Moscarda, Sarah Pafumi, Anna Reni, Giulia Sartori, Ilaria Mariangela Scaglione, Yiftach Shoval, Marco Sposito, Evelina Tacconelli, Ilaria Trestini, Valentina Zambonin, Sara Zanelli, Sara Pilotto, Michele Milella
BACKGROUND: On February 23rd, the 1st case of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection was diagnosed at the University Hospital Trust of Verona, Italy. On March 13th, the Oncology Section was converted into a 22-inpatient bed coronavirus disease (COVID) Unit, and we reshaped our organisation to face the SARS-CoV-2 epidemic, while maintaining oncological activities. METHODS: We tracked down (i) volumes of oncological activities (January 1st - March 31st, 2020 versus the same period of 2019), (ii) patients' and caregivers' perception and (iii) SARS-CoV-2 infection rate in oncology health professionals and SARS-CoV-2 infection-related hospital admissions of "active"' oncological patients...
August 2020: European Journal of Cancer
#15
MULTICENTER STUDY
Riccardo Orlandi, Sara Mariotto, Sergio Ferrari, Francesca Gobbin, Elia Sechi, Ruggero Capra, Chiara Rosa Mancinelli, Roberto Bombardi, Luigi Zuliani, Marco Zoccarato, Francesca Rossi, Valentina Camera, Diana Ferraro, Maria Donata Benedetti, Markus Reindl, Alberto Gajofatto
BACKGROUND: Myelin oligodendrocyte glycoprotein (MOG)-IgG associated disorders are increasingly recognized as a distinct disease entity. However, diagnostic sensitivity and specificity of serum MOG-IgG as well as recommendations for testing are still debated. MATERIALS AND METHODS: Between October 2015 and July 2017 we tested serum MOG-IgG in 91 adult patients (49 females) with a demyelinating event (DE) not fulfilling 2010 McDonald criteria for MS at sampling, negative for neuromyelitis optica (NMO)-IgG and followed-up for at least 12 months...
July 15, 2020: Journal of Neuroimmunology
#16
MULTICENTER STUDY
Giovanni Novi, Francesca Bovis, Marco Capobianco, Jessica Frau, Giorgia Mataluni, Erica Curti, Luigi Zuliani, Paola Cavalla, Laura Brambilla, Pietro Annovazzi, Anna Maria Repice, Roberta Lanzillo, Sabrina Esposito, Luana Benedetti, Ilaria Maietta, Francesco Sica, Fabio Buttari, Simona Malucchi, Giuseppe Fenu, Doriana Landi, Chiara Bosa, Sabrina Realmuto, Maria Malentacchi, Franco Granella, Alessio Signori, Simona Bonavita, Antonio Uccelli, Maria Pia Sormani
OBJECTIVE: To evaluate disease activity according to rituximab (RTX) induction and maintenance regimens in a multicenter real-life dataset of NMOSD patients. METHODS: This is an observational-retrospective multicentre study including patients with NMOSD treated with RTX in 21 Italian and 1 Swiss centers. Demographics, relapse rate and adverse events over the follow-up were summarized taking into account induction strategy (two-1 g infusions at a 15-day interval (IND-A) vs...
November 2019: Multiple Sclerosis and related Disorders
#17
JOURNAL ARTICLE
Gloria Brombo, Francesco Bonetti, Stefano Volpato, Mario L Morieri, Ettore Napoli, Stefania Bandinelli, Antonio Cherubini, Marcello Maggio, Jack Guralnik, Luigi Ferrucci, Giovanni Zuliani
BACKGROUND AND AIMS: Increased uric acid levels correlate with cardiovascular disease and cardiovascular/overall mortality. To identify a uric acid threshold above which cardiovascular mortality rises, we studied the relationship between uric acid concentration and overall/cardiovascular mortality. METHODS AND RESULTS: We analyzed data from the InCHIANTI study, a cohort study of Italian community-dwelling people with 9 years of follow-up. We selected a sample of 947 individuals over 64 years of age, free from cardio-cerebrovascular disease and with available uric acid measurement at baseline...
October 2019: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
#18
JOURNAL ARTICLE
Margherita Nosadini, Irene Toldo, Benedetta Tascini, Christian G Bien, Lucio Parmeggiani, Piera De Gaspari, Luigi Zuliani, Stefano Sartori
Leucine-rich glioma-inactivated protein 1 (LGI1) and contactin-associated protein-like 2 (CASPR2) neurological autoimmunity in adults has been associated with various clinical syndromes involving central, peripheral and autonomic nervous system, while data in children is limited. We perform the first systematic literature review on paediatric LGI1 and CASPR2 autoimmunity, with focus on clinical data, in order to contribute to the definition of clinical features of LGI1 and CASPR2 autoimmunity in paediatric age and favour early diagnosis...
October 15, 2019: Journal of Neuroimmunology
#19
REVIEW
Luigi Zuliani, Margherita Nosadini, Matteo Gastaldi, Marianna Spatola, Raffaele Iorio, Marco Zoccarato, Sara Mariotto, Piera De Gaspari, Francesco Perini, Sergio Ferrari, Amelia Evoli, Stefano Sartori, Diego Franciotta, Bruno Giometto
Autoimmune encephalitis associated with antibodies against neuronal surface targets (NSAE) are rare but still underrecognized conditions that affect adult and pediatric patients. Clinical guidelines have recently been published with the aim of providing diagnostic clues regardless of antibody status. These syndromes are potentially treatable but the choice of treatment and its timing, as well as differential diagnoses, long-term management, and clinical and paraclinical follow-up, remain major challenges. In the absence of evidence-based guidelines, management of these conditions is commonly based on single-center expertise...
October 2019: Neurological Sciences
#20
JOURNAL ARTICLE
Marco Zoccarato, Silvia Valeggia, Luigi Zuliani, Matteo Gastaldi, Sara Mariotto, Diego Franciotta, Sergio Ferrari, Giuseppe Lombardi, Vittorina Zagonel, Piera De Gaspari, Mario Ermani, Alessio Signori, Anna Pichiecchio, Bruno Giometto, Renzo Manara
PURPOSE: Radiological hallmark of autoimmune limbic encephalitis (LE) is a hyperintense signal in MRI T2-weighted images of mesial temporal structures. We aimed to identify conventional magnetic resonance imaging (MRI) features that can help distinguish LE from temporal glioma. METHODS: Brain MRIs of 25 patients affected by antibody-positive autoimmune LE, 24 patients affected by temporal glioma (tumor group), and 5 negative controls were retrospectively blindly evaluated in random order...
August 2019: Neuroradiology
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