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Zuliani, luigi

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https://www.readbyqxmd.com/read/29063242/clinical-spectrum-and-igg-subclass-analysis-of-anti-myelin-oligodendrocyte-glycoprotein-antibody-associated-syndromes-a-multicenter-study
#1
Sara Mariotto, Sergio Ferrari, Salvatore Monaco, Maria Donata Benedetti, Kathrin Schanda, Daniela Alberti, Alessia Farinazzo, Ruggero Capra, Chiara Mancinelli, Nicola De Rossi, Roberto Bombardi, Luigi Zuliani, Marco Zoccarato, Raffaella Tanel, Adriana Bonora, Marco Turatti, Massimiliano Calabrese, Alberto Polo, Antonino Pavone, Luisa Grazian, GianPietro Sechi, Elia Sechi, Daniele Urso, Rachele Delogu, Francesco Janes, Luciano Deotto, Morena Cadaldini, Maria Rachele Bianchi, Gaetano Cantalupo, Markus Reindl, Alberto Gajofatto
Anti-myelin oligodendrocyte glycoprotein antibodies (MOG-Ab) recently emerged as a potential biomarker in patients with inflammatory demyelinating diseases of the central nervous system. We here compare the clinical and laboratory findings observed in a cohort of MOG-Ab seropositive and seronegative cases and describe IgG subclass analysis results. Consecutive serum samples referred to Verona University Neuropathology Laboratory for aquaporin-4 (AQP4)-Ab and/or MOG-Ab testing were analysed between March 2014 and May 2017...
October 23, 2017: Journal of Neurology
https://www.readbyqxmd.com/read/29030768/diagnostics-of-the-neuromyelitis-optica-spectrum-disorders-nmosd
#2
REVIEW
Diego Franciotta, Matteo Gastaldi, Arianna Sala, Francesca Andreetta, Elena Rinaldi, Maddalena Ruggieri, Rosaria Leante, Gianna Costa, Tiziana Biagioli, Luca Massacesi, Elena Bazzigaluppi, Raffaella Fazio, Sara Mariotto, Sergio Ferrari, Elisabetta Galloni, Francesco Perini, Elisabetta Zardini, Luigi Zuliani, Marco Zoccarato, Bruno Giometto, Antonio Bertolotto
This document presents the guidelines for anti-aquaporin-4 (AQP4) antibody testing that has been developed following a consensus process built on questionnaire-based surveys, internet contacts, and discussions at workshops of the sponsoring Italian Association of Neuroimmunology (AINI) congresses. Essential clinical information on neuromyelitis optica spectrum disorders, indications and limits of anti-AQP4 antibody testing, instructions for result interpretation, and an agreed laboratory protocol (Appendix) are reported for the communicative community of neurologists and clinical pathologists...
October 2017: Neurological Sciences
https://www.readbyqxmd.com/read/29030767/diagnostics-of-autoimmune-encephalitis-associated-with-antibodies-against-neuronal-surface-antigens
#3
REVIEW
Luigi Zuliani, Marco Zoccarato, Matteo Gastaldi, Raffaele Iorio, Amelia Evoli, Tiziana Biagioli, Silvia Casagrande, Elena Bazzigaluppi, Raffaella Fazio, Claudia Giannotta, Eduardo Nobile-Orazio, Francesca Andreetta, Ornella Simoncini, Gianna Costa, Sara Mariotto, Sergio Ferrari, Elisabetta Galloni, Michela Marcon, Diego Franciotta, Bruno Giometto
This document presents the guidelines for testing antibodies against neuronal surface antigens that have been developed following a consensus process built on questionnaire-based surveys, internet contacts, and discussions at workshops of the sponsoring Italian Association of Neuroimmunology (AINI) congresses. Essential clinical information on autoimmune encephalitis associated with antibodies against neuronal surface antigens, indications and limits of testing for such antibodies, instructions for result interpretation, and an agreed laboratory protocol (Appendix A) are reported for the communicative community of neurologists and clinical pathologists...
October 2017: Neurological Sciences
https://www.readbyqxmd.com/read/29030766/diagnostics-of-paraneoplastic-neurological-syndromes
#4
REVIEW
Marco Zoccarato, Matteo Gastaldi, Luigi Zuliani, Tiziana Biagioli, Marco Brogi, Gaetano Bernardi, Elena Corsini, Elena Bazzigaluppi, Raffaella Fazio, Claudia Giannotta, Eduardo Nobile-Orazio, Gianna Costa, Raffaele Iorio, Amelia Evoli, Sara Mariotto, Sergio Ferrari, Elisabetta Galloni, Valentina De Riva, Elisabetta Zardini, Diego Franciotta, Bruno Giometto
This document presents the guidelines for onconeural antibody testing that have been developed following a consensus process built on questionnaire-based surveys, internet contacts, and discussions at workshops of the sponsoring Italian Association of Neuroimmunology (AINI) congresses. Essential clinical information on paraneoplastic neurological syndromes, indications and limits of onconeural antibody testing, instructions for result interpretation, and an agreed laboratory protocol (Appendix) are reported for the communicative community of neurologists and clinical pathologists...
October 2017: Neurological Sciences
https://www.readbyqxmd.com/read/28957382/combining-ldl-c-and-hdl-c-to-predict-survival-in-late-life-the-inchianti-study
#5
Giovanni Zuliani, Stefano Volpato, Marco Dugo, Giovanni B Vigna, Mario Luca Morieri, Marcello Maggio, Antonio Cherubini, Stefania Bandinelli, Jack M Guralnik, Luigi Ferrucci
BACKGROUND: While the relationship between total cholesterol (TC) and cardiovascular disease (CVD) progressively weakens with aging, several studies have shown that low TC is associated with increased mortality in older individuals. However, the possible additive/synergic contribution of the two most important cholesterol rich fractions (LDL-C and HDL-C) to mortality risk has not been previously investigated. Our study aimed to investigate the relationship between baseline LDL-C and HDL-C, both separately and combined, and 9-years mortality in a sample of community dwelling older individuals from the InCHIANTI study...
2017: PloS One
https://www.readbyqxmd.com/read/28029688/combining-gait-speed-and-recall-memory-to-predict-survival-in-late-life-population-based-study
#6
Alessandra Marengoni, Stefania Bandinelli, Elisa Maietti, Jack Guralnik, Giovanni Zuliani, Luigi Ferrucci, Stefano Volpato
OBJECTIVES: To evaluate the relationship between gait speed, recall memory, and mortality. DESIGN: A cohort study (last follow-up December 2009). SETTING: Tuscany, Italy. PARTICIPANTS: Individual data from 1,014 community-dwelling older adults aged 60 years or older with baseline gait speed and recall memory measurements and follow-up for a median time of 9.10 (IQR 7.1;9.3) years. Participants were a mean (SD) age of 73...
March 2017: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/27710962/voltage-gated-potassium-channel-antibodies-in-slow-progression-motor-neuron-disease
#7
MULTICENTER STUDY
Massimiliano Godani, Marco Zoccarato, Alessandro Beronio, Luigi Zuliani, Luana Benedetti, Bruno Giometto, Massimo Del Sette, Elisa Raggio, Roberta Baldi, Angela Vincent
BACKGROUND: The spectrum of autoimmune neurological diseases associated with voltage-gated potassium channel (VGKC)-complex antibodies (Abs) ranges from peripheral nerve disorders to limbic encephalitis. Recently, low titers of VGKC-complex Abs have also been reported in neurodegenerative disorders, but their clinical relevance is unknown. OBJECTIVE: The aim of the study was to explore the prevalence of VGKC-complex Abs in slow-progression motor neuron disease (MND)...
2017: Neuro-degenerative Diseases
https://www.readbyqxmd.com/read/27113605/multicentre-comparison-of-a-diagnostic-assay-aquaporin-4-antibodies-in-neuromyelitis-optica
#8
RANDOMIZED CONTROLLED TRIAL
Patrick Waters, Markus Reindl, Albert Saiz, Kathrin Schanda, Friederike Tuller, Vlastimil Kral, Petra Nytrova, Ondrej Sobek, Helle Hvilsted Nielsen, Torben Barington, Søren T Lillevang, Zsolt Illes, Kristin Rentzsch, Achim Berthele, Tímea Berki, Letizia Granieri, Antonio Bertolotto, Bruno Giometto, Luigi Zuliani, Dörte Hamann, E Daniëlle van Pelt, Rogier Hintzen, Romana Höftberger, Carme Costa, Manuel Comabella, Xavier Montalban, Mar Tintoré, Aksel Siva, Ayse Altintas, Günnur Deniz, Mark Woodhall, Jacqueline Palace, Friedemann Paul, Hans-Peter Hartung, Orhan Aktas, Sven Jarius, Brigitte Wildemann, Christian Vedeler, Anne Ruiz, M Isabel Leite, Peter Trillenberg, Monika Probst, Sandra Saschenbrecker, Angela Vincent, Romain Marignier
OBJECTIVE: Antibodies to cell surface central nervous system proteins help to diagnose conditions which often respond to immunotherapies. The assessment of antibody assays needs to reflect their clinical utility. We report the results of a multicentre study of aquaporin (AQP) 4 antibody (AQP4-Ab) assays in neuromyelitis optica spectrum disorders (NMOSD). METHODS: Coded samples from patients with neuromyelitis optica (NMO) or NMOSD (101) and controls (92) were tested at 15 European diagnostic centres using 21 assays including live (n=3) or fixed cell-based assays (n=10), flow cytometry (n=4), immunohistochemistry (n=3) and ELISA (n=1)...
September 2016: Journal of Neurology, Neurosurgery, and Psychiatry
https://www.readbyqxmd.com/read/26926399/plasma-exchange-in-pediatric-anti-nmdar-encephalitis-a-systematic-review
#9
REVIEW
Agnese Suppiej, Margherita Nosadini, Luigi Zuliani, Maria Federica Pelizza, Irene Toldo, Chiara Bertossi, Tiziana Tison, Marco Zoccarato, Piero Marson, Bruno Giometto, Russell C Dale, Stefano Sartori
OBJECTIVE: To clarify the most frequent modalities of use of plasma exchange (PE) in pediatric anti-N-methyl-d-aspartate receptor (anti-NMDAR) encephalitis and to establish the most effective association with other immunotherapies. METHODS: Systematic literature review on PE in pediatric anti-NMDAR encephalitis (2007-2015). RESULTS: Seventy-one articles were included (mostly retrospective), reporting a total of 242 subjects (73.2%, 93/127 females; median age at onset 12years, range 1-18)...
August 2016: Brain & Development
https://www.readbyqxmd.com/read/26335011/role-of-amylase-%C3%AE-2a-autoantibodies-in-the-diagnosis-of-autoimmune-pancreatitis
#10
María Sánchez Castañón, Valeria Zuliani, Antonio Amodio, Pietro Campagnola, Anna Granato, Armando Gabbrielli, Luigi Benini, Marcos López Hoyos, Luca Frulloni
OBJECTIVES: Several serological markers have been reported in autoimmune pancreatitis (AIP) patients. However, only serum IgG4 (sIgG4) is available in clinical practice for AIP diagnosis. Antiamylase α antibodies (AMY-α Abs) have been proposed to diagnose AIP. This study evaluates the utility of AMY-α Abs and sIgG4 for AIP diagnosis. METHODS: Twenty-five AIP patients, 84 disease control groups (31 chronic pancreatitis, 30 acute pancreatitis, 23 pancreatic adenocarcinoma), and 59 healthy donors were prospectively studied...
October 2015: Pancreas
https://www.readbyqxmd.com/read/26333772/the-predictive-value-of-the-ewgsop-definition-of-sarcopenia-results-from-the-inchianti-study
#11
Lara Bianchi, Luigi Ferrucci, Antonio Cherubini, Marcello Maggio, Stefania Bandinelli, Elisabetta Savino, Gloria Brombo, Giovanni Zuliani, Jack M Guralnik, Francesco Landi, Stefano Volpato
BACKGROUND: Sarcopenia is associated with increased risk of adverse outcomes in older people. Aim of the study was to explore the predictive value of the European Working Group on Sarcopenia in Older People (EWGSOP) diagnostic algorithm in terms of disability, hospitalization, and mortality and analyze the specific role of grip strength and walking speed as diagnostic criteria for sarcopenia. METHODS: Longitudinal analysis of 538 participants enrolled in the InCHIANTI study...
February 2016: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/26209928/intravenous-thrombolysis-for-acute-stroke-in-a-patient-on-treatment-with-rivaroxaban
#12
LETTER
Lucia Nardetto, Simone Tonello, Luigi Zuliani, Bruno Giometto
No abstract text is available yet for this article.
December 2015: Neurological Sciences
https://www.readbyqxmd.com/read/25340068/glycine-receptor-antibodies-in-2-cases-of-new-adult-onset-epilepsy
#13
Luigi Zuliani, Edoardo Ferlazzo, Cinzia Andrigo, Alessandro Casano, Vittoria Cianci, Marco Zoccarato, Maria Isabel Leite, Patrick Waters, Mark Woodhall, Ernesto Della Mora, Michele Morra, Bruno Giometto, Umberto Aguglia, Angela Vincent
No abstract text is available yet for this article.
August 2014: Neurology® Neuroimmunology & Neuroinflammation
https://www.readbyqxmd.com/read/24956526/insulin-resistance-and-systemic-inflammation-but-not-metabolic-syndrome-phenotype-predict-9-years-mortality-in-older-adults
#14
Giovanni Zuliani, Mario Luca Morieri, Stefano Volpato, Marcello Maggio, Antonio Cherubini, Daniela Francesconi, Stefania Bandinelli, Giuseppe Paolisso, Jack M Guralnik, Luigi Ferrucci
BACKGROUND: Although metabolic syndrome (MS) is a typical condition of middle-aged/older person, the association between MS and mortality risk has not been confirmed in people over 65 years. We hypothesized that while in the elderly MS phenotype might lose its value in predicting mortality risk, the two core factors of MS, i.e. insulin resistance (IR) and low grade systemic inflammation (LGSI) would not. METHODS: 1011 community-dwelling older individuals (InCHIANTI study) were included...
August 2014: Atherosclerosis
https://www.readbyqxmd.com/read/24396130/longitudinal-electroencephalographic-eeg-findings-in-pediatric-anti-n-methyl-d-aspartate-anti-nmda-receptor-encephalitis-the-padua-experience
#15
Margherita Nosadini, Clementina Boniver, Luigi Zuliani, Luca de Palma, Elisa Cainelli, Pier Antonio Battistella, Irene Toldo, Agnese Suppiej, Stefano Sartori
To contribute to characterize electroencephalographic (EEG) activity in pediatric anti-N-methyl-d-aspartate (anti-NMDA) receptor encephalitis, we reviewed electroclinical data of 5 children with anti-NMDA receptor encephalitis diagnosed in our department. We identified 4 longitudinal electroencephalographic phases: in the early phase, background activity was normal, with intermixed nonreactive slow waves; in the florid phase, background activity deteriorated with appearance of sequences of peculiar rhythmic theta and/or delta activity unrelated to clinical changes, unresponsive to stimuli and antiepileptic medications; in the recovery phase, these sequences decreased and reactive posterior rhythm re-emerged; electroencephalogram normalized 2 to 5 months after onset...
February 2015: Journal of Child Neurology
https://www.readbyqxmd.com/read/24253480/aquaporin-4-antibody-neuromyelitis-optica-following-anti-nmda-receptor-encephalitis
#16
LETTER
Marco Zoccarato, Maria Valeria Saddi, Giulia Serra, Maria Federica Pelizza, Irene Rosellini, Luigi Peddone, Anna Ticca, Bruno Giometto, Luigi Zuliani
No abstract text is available yet for this article.
December 2013: Journal of Neurology
https://www.readbyqxmd.com/read/24085400/prevalence-and-clinical-correlates-of-sarcopenia-in-community-dwelling-older-people-application-of-the-ewgsop-definition-and-diagnostic-algorithm
#17
Stefano Volpato, Lara Bianchi, Antonio Cherubini, Francesco Landi, Marcello Maggio, Elisabetta Savino, Stefania Bandinelli, Gian Paolo Ceda, Jack M Guralnik, Giovanni Zuliani, Luigi Ferrucci
BACKGROUND: Muscle impairment is a common condition in older people and a powerful risk factor for disability and mortality. The aim of this study was to apply the European Working Group on Sarcopenia in Older People criteria to estimate the prevalence and investigate the clinical correlates of sarcopenia, in a sample of Italian community-dwelling older people. METHODS: Cross-sectional analysis of 730 participants (74% aged 65 years and older) enrolled in the InCHIANTI study...
April 2014: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/23141584/determinants-and-clinical-significance-of-plasma-oxidized-ldls-in-older-individuals-a-9-years-follow-up-study
#18
Giovanni Zuliani, Mario Luca Morieri, Stefano Volpato, Giovanni B Vigna, Cristina Bosi, Marcello Maggio, Antonio Cherubini, Stefania Bandinelli, Jack M Guralnik, Luigi Ferrucci
Oxidized LDLs (ox.LDLs) uptake by macrophages inside the arterial wall is a crucial step in atherosclerotic disease, and some studies suggest that high ox.LDLs plasma levels might be associated with cardiovascular disease (CVD). However, whether high ox.LDLs continue to be a CVD risk factors in older persons is unknown. We investigated the clinical correlates of plasma ox.LDLs, and their role in predicting long-term CVD/cardiac mortality in 1025 older community dwelling individuals (mean age: 75.5 ± 7.4 years; females: 55%) from the InCHIANTI study...
January 2013: Atherosclerosis
https://www.readbyqxmd.com/read/23111027/cacna1h-antibodies-associated-with-headache-with-neurological-deficits-and-cerebrospinal-fluid-lymphocytosis-handl
#19
Murat Kürtüncü, Dilaver Kaya, Luigi Zuliani, Ece Erdağ, Sema Içöz, Elif Uğurel, Filiz Cavuş, Neşe Ayşit, Omer Birişik, Angela Vincent, Mefkure Eraksoy, Burçak Vural, Gülşen Akman-Demir, Erdem Tüzün
BACKGROUND: Patients with the syndrome of headache with neurological deficits and lymphocytosis (HaNDL) typically present with recurrent and temporary attacks of neurological symptoms and cerebrospinal fluid lymphocytosis. AIM AND METHODS: To identify potential HaNDL-associated antibodies directed against neuronal surface and/or synapse antigens, sera of four HaNDL patients and controls were screened with indirect immunohistochemistry, immunofluorescence, cell-based assay, radioimmunoassay, protein macroarray and enzyme-linked immunosorbent assay (ELISA)...
January 2013: Cephalalgia: An International Journal of Headache
https://www.readbyqxmd.com/read/22596176/role-of-muscle-mass-and-muscle-quality-in-the-association-between-diabetes-and-gait-speed
#20
Stefano Volpato, Lara Bianchi, Fulvio Lauretani, Fabrizio Lauretani, Stefania Bandinelli, Jack M Guralnik, Giovanni Zuliani, Luigi Ferrucci
OBJECTIVE: Older people with type 2 diabetes are at high risk of mobility disability. We investigated the association of diabetes with lower-limb muscle mass and muscle quality to verify whether diabetes-related muscle impairments mediate the association between diabetes and low walking speed. RESEARCH DESIGN AND METHODS: We performed a cross-sectional analysis of 835 participants (65 years old and older) enrolled in the InCHIANTI (Invecchiare in Chianti, aging in the Chianti area) population-based study...
August 2012: Diabetes Care
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