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Zuliani, luigi

Alessandra Marengoni, Stefania Bandinelli, Elisa Maietti, Jack Guralnik, Giovanni Zuliani, Luigi Ferrucci, Stefano Volpato
OBJECTIVES: To evaluate the relationship between gait speed, recall memory, and mortality. DESIGN: A cohort study (last follow-up December 2009). SETTING: Tuscany, Italy. PARTICIPANTS: Individual data from 1,014 community-dwelling older adults aged 60 years or older with baseline gait speed and recall memory measurements and follow-up for a median time of 9.10 (IQR 7.1;9.3) years. Participants were a mean (SD) age of 73...
March 2017: Journal of the American Geriatrics Society
Massimiliano Godani, Marco Zoccarato, Alessandro Beronio, Luigi Zuliani, Luana Benedetti, Bruno Giometto, Massimo Del Sette, Elisa Raggio, Roberta Baldi, Angela Vincent
BACKGROUND: The spectrum of autoimmune neurological diseases associated with voltage-gated potassium channel (VGKC)-complex antibodies (Abs) ranges from peripheral nerve disorders to limbic encephalitis. Recently, low titers of VGKC-complex Abs have also been reported in neurodegenerative disorders, but their clinical relevance is unknown. OBJECTIVE: The aim of the study was to explore the prevalence of VGKC-complex Abs in slow-progression motor neuron disease (MND)...
2017: Neuro-degenerative Diseases
Patrick Waters, Markus Reindl, Albert Saiz, Kathrin Schanda, Friederike Tuller, Vlastimil Kral, Petra Nytrova, Ondrej Sobek, Helle Hvilsted Nielsen, Torben Barington, Søren T Lillevang, Zsolt Illes, Kristin Rentzsch, Achim Berthele, Tímea Berki, Letizia Granieri, Antonio Bertolotto, Bruno Giometto, Luigi Zuliani, Dörte Hamann, E Daniëlle van Pelt, Rogier Hintzen, Romana Höftberger, Carme Costa, Manuel Comabella, Xavier Montalban, Mar Tintoré, Aksel Siva, Ayse Altintas, Günnur Deniz, Mark Woodhall, Jacqueline Palace, Friedemann Paul, Hans-Peter Hartung, Orhan Aktas, Sven Jarius, Brigitte Wildemann, Christian Vedeler, Anne Ruiz, M Isabel Leite, Peter Trillenberg, Monika Probst, Sandra Saschenbrecker, Angela Vincent, Romain Marignier
OBJECTIVE: Antibodies to cell surface central nervous system proteins help to diagnose conditions which often respond to immunotherapies. The assessment of antibody assays needs to reflect their clinical utility. We report the results of a multicentre study of aquaporin (AQP) 4 antibody (AQP4-Ab) assays in neuromyelitis optica spectrum disorders (NMOSD). METHODS: Coded samples from patients with neuromyelitis optica (NMO) or NMOSD (101) and controls (92) were tested at 15 European diagnostic centres using 21 assays including live (n=3) or fixed cell-based assays (n=10), flow cytometry (n=4), immunohistochemistry (n=3) and ELISA (n=1)...
September 2016: Journal of Neurology, Neurosurgery, and Psychiatry
Agnese Suppiej, Margherita Nosadini, Luigi Zuliani, Maria Federica Pelizza, Irene Toldo, Chiara Bertossi, Tiziana Tison, Marco Zoccarato, Piero Marson, Bruno Giometto, Russell C Dale, Stefano Sartori
OBJECTIVE: To clarify the most frequent modalities of use of plasma exchange (PE) in pediatric anti-N-methyl-d-aspartate receptor (anti-NMDAR) encephalitis and to establish the most effective association with other immunotherapies. METHODS: Systematic literature review on PE in pediatric anti-NMDAR encephalitis (2007-2015). RESULTS: Seventy-one articles were included (mostly retrospective), reporting a total of 242 subjects (73.2%, 93/127 females; median age at onset 12years, range 1-18)...
August 2016: Brain & Development
María Sánchez Castañón, Valeria Zuliani, Antonio Amodio, Pietro Campagnola, Anna Granato, Armando Gabbrielli, Luigi Benini, Marcos López Hoyos, Luca Frulloni
OBJECTIVES: Several serological markers have been reported in autoimmune pancreatitis (AIP) patients. However, only serum IgG4 (sIgG4) is available in clinical practice for AIP diagnosis. Antiamylase α antibodies (AMY-α Abs) have been proposed to diagnose AIP. This study evaluates the utility of AMY-α Abs and sIgG4 for AIP diagnosis. METHODS: Twenty-five AIP patients, 84 disease control groups (31 chronic pancreatitis, 30 acute pancreatitis, 23 pancreatic adenocarcinoma), and 59 healthy donors were prospectively studied...
October 2015: Pancreas
Lara Bianchi, Luigi Ferrucci, Antonio Cherubini, Marcello Maggio, Stefania Bandinelli, Elisabetta Savino, Gloria Brombo, Giovanni Zuliani, Jack M Guralnik, Francesco Landi, Stefano Volpato
BACKGROUND: Sarcopenia is associated with increased risk of adverse outcomes in older people. Aim of the study was to explore the predictive value of the European Working Group on Sarcopenia in Older People (EWGSOP) diagnostic algorithm in terms of disability, hospitalization, and mortality and analyze the specific role of grip strength and walking speed as diagnostic criteria for sarcopenia. METHODS: Longitudinal analysis of 538 participants enrolled in the InCHIANTI study...
February 2016: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
Lucia Nardetto, Simone Tonello, Luigi Zuliani, Bruno Giometto
No abstract text is available yet for this article.
December 2015: Neurological Sciences
Luigi Zuliani, Edoardo Ferlazzo, Cinzia Andrigo, Alessandro Casano, Vittoria Cianci, Marco Zoccarato, Maria Isabel Leite, Patrick Waters, Mark Woodhall, Ernesto Della Mora, Michele Morra, Bruno Giometto, Umberto Aguglia, Angela Vincent
No abstract text is available yet for this article.
August 2014: Neurology® Neuroimmunology & Neuroinflammation
Giovanni Zuliani, Mario Luca Morieri, Stefano Volpato, Marcello Maggio, Antonio Cherubini, Daniela Francesconi, Stefania Bandinelli, Giuseppe Paolisso, Jack M Guralnik, Luigi Ferrucci
BACKGROUND: Although metabolic syndrome (MS) is a typical condition of middle-aged/older person, the association between MS and mortality risk has not been confirmed in people over 65 years. We hypothesized that while in the elderly MS phenotype might lose its value in predicting mortality risk, the two core factors of MS, i.e. insulin resistance (IR) and low grade systemic inflammation (LGSI) would not. METHODS: 1011 community-dwelling older individuals (InCHIANTI study) were included...
August 2014: Atherosclerosis
Margherita Nosadini, Clementina Boniver, Luigi Zuliani, Luca de Palma, Elisa Cainelli, Pier Antonio Battistella, Irene Toldo, Agnese Suppiej, Stefano Sartori
To contribute to characterize electroencephalographic (EEG) activity in pediatric anti-N-methyl-d-aspartate (anti-NMDA) receptor encephalitis, we reviewed electroclinical data of 5 children with anti-NMDA receptor encephalitis diagnosed in our department. We identified 4 longitudinal electroencephalographic phases: in the early phase, background activity was normal, with intermixed nonreactive slow waves; in the florid phase, background activity deteriorated with appearance of sequences of peculiar rhythmic theta and/or delta activity unrelated to clinical changes, unresponsive to stimuli and antiepileptic medications; in the recovery phase, these sequences decreased and reactive posterior rhythm re-emerged; electroencephalogram normalized 2 to 5 months after onset...
February 2015: Journal of Child Neurology
Marco Zoccarato, Maria Valeria Saddi, Giulia Serra, Maria Federica Pelizza, Irene Rosellini, Luigi Peddone, Anna Ticca, Bruno Giometto, Luigi Zuliani
No abstract text is available yet for this article.
December 2013: Journal of Neurology
Stefano Volpato, Lara Bianchi, Antonio Cherubini, Francesco Landi, Marcello Maggio, Elisabetta Savino, Stefania Bandinelli, Gian Paolo Ceda, Jack M Guralnik, Giovanni Zuliani, Luigi Ferrucci
BACKGROUND: Muscle impairment is a common condition in older people and a powerful risk factor for disability and mortality. The aim of this study was to apply the European Working Group on Sarcopenia in Older People criteria to estimate the prevalence and investigate the clinical correlates of sarcopenia, in a sample of Italian community-dwelling older people. METHODS: Cross-sectional analysis of 730 participants (74% aged 65 years and older) enrolled in the InCHIANTI study...
April 2014: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
Giovanni Zuliani, Mario Luca Morieri, Stefano Volpato, Giovanni B Vigna, Cristina Bosi, Marcello Maggio, Antonio Cherubini, Stefania Bandinelli, Jack M Guralnik, Luigi Ferrucci
Oxidized LDLs (ox.LDLs) uptake by macrophages inside the arterial wall is a crucial step in atherosclerotic disease, and some studies suggest that high ox.LDLs plasma levels might be associated with cardiovascular disease (CVD). However, whether high ox.LDLs continue to be a CVD risk factors in older persons is unknown. We investigated the clinical correlates of plasma ox.LDLs, and their role in predicting long-term CVD/cardiac mortality in 1025 older community dwelling individuals (mean age: 75.5 ± 7.4 years; females: 55%) from the InCHIANTI study...
January 2013: Atherosclerosis
Murat Kürtüncü, Dilaver Kaya, Luigi Zuliani, Ece Erdağ, Sema Içöz, Elif Uğurel, Filiz Cavuş, Neşe Ayşit, Omer Birişik, Angela Vincent, Mefkure Eraksoy, Burçak Vural, Gülşen Akman-Demir, Erdem Tüzün
BACKGROUND: Patients with the syndrome of headache with neurological deficits and lymphocytosis (HaNDL) typically present with recurrent and temporary attacks of neurological symptoms and cerebrospinal fluid lymphocytosis. AIM AND METHODS: To identify potential HaNDL-associated antibodies directed against neuronal surface and/or synapse antigens, sera of four HaNDL patients and controls were screened with indirect immunohistochemistry, immunofluorescence, cell-based assay, radioimmunoassay, protein macroarray and enzyme-linked immunosorbent assay (ELISA)...
January 2013: Cephalalgia: An International Journal of Headache
Stefano Volpato, Lara Bianchi, Fulvio Lauretani, Fabrizio Lauretani, Stefania Bandinelli, Jack M Guralnik, Giovanni Zuliani, Luigi Ferrucci
OBJECTIVE: Older people with type 2 diabetes are at high risk of mobility disability. We investigated the association of diabetes with lower-limb muscle mass and muscle quality to verify whether diabetes-related muscle impairments mediate the association between diabetes and low walking speed. RESEARCH DESIGN AND METHODS: We performed a cross-sectional analysis of 835 participants (65 years old and older) enrolled in the InCHIANTI (Invecchiare in Chianti, aging in the Chianti area) population-based study...
August 2012: Diabetes Care
Sarosh R Irani, Philippa Pettingill, Kleopas A Kleopa, Natasa Schiza, Patrick Waters, Claudio Mazia, Luigi Zuliani, Osamu Watanabe, Bethan Lang, Camilla Buckley, Angela Vincent
OBJECTIVE: A study was undertaken to describe the clinical spectrum, voltage-gated potassium channel (VGKC) complex antibody specificities, and central nervous system localization of antibody binding in 29 patients diagnosed with Morvan syndrome (MoS). METHODS: Clinical data were collected using questionnaires. Radioimmunoassay, cell-based assays, and mouse brain immunohistochemistry were used to characterize the serum antibodies. RESULTS: Neuromyotonia (100%), neuropsychiatric features (insomnia 89...
August 2012: Annals of Neurology
Luigi Zuliani, Francesc Graus, Bruno Giometto, Christian Bien, Angela Vincent
The concept of antibody mediated CNS disorders is relatively recent. The classical CNS paraneoplastic neurological syndromes are thought to be T cell mediated, and the onconeural antibodies merely biomarkers for the presence of the tumour. Thus it was thought that antibodies rarely, if ever, cause CNS disease. Over the past 10 years, identification of autoimmune forms of encephalitis with antibodies against neuronal surface antigens, particularly the voltage gated potassium channel complex proteins or the glutamate N-methyl-D-aspartate receptor, have shown that CNS disorders, often without associated tumours, can be antibody mediated and benefit from immunomodulatory therapies...
June 2012: Journal of Neurology, Neurosurgery, and Psychiatry
Esther B E Becker, Luigi Zuliani, Rosemary Pettingill, Bethan Lang, Patrick Waters, Anna Dulneva, Frank Sobott, Mark Wardle, Francesc Graus, Luis Bataller, Neil P Robertson, Angela Vincent
BACKGROUND: Relatively few studies have searched for potentially pathogenic antibodies in non-paraneoplastic patients with cerebellar ataxia. METHODS AND RESULTS: We first screened sera from 52 idiopathic ataxia patients for binding of serum IgG antibodies to cerebellar neurons. One strong-binding serum was selected for immunoprecipitation and mass spectrometry, which resulted in the identification of contactin-associated protein 2 (CASPR2) as a major antigen. CASPR2 antibodies were then found by a cell-based assay in 9/88 (10%) ataxia patients, compared to 3/144 (2%) multiple sclerosis or dementia controls (p=0...
April 2012: Journal of Neurology, Neurosurgery, and Psychiatry
Burçak Vural, Elif Uğurel, Erdem Tüzün, Murat Kürtüncü, Luigi Zuliani, Filiz Cavuş, Sema Içöz, Ece Erdağ, Ahmet Gül, Ali O Güre, Angela Vincent, Uğur Ozbek, Mefkure Eraksoy, Gülşen Akman-Demir
No disease-specific neuronal antibodies have so far been defined in neuro-Behçet's disease (NBD). Immunohistochemistry and immunocytochemistry studies showed antibodies to hippocampal and cerebellar molecular layers and the surface antigens of cultured hippocampal neurons in sera and/or cerebrospinal fluids (CSF) of 13 of 20 NBD and 6 of 20 BD patients but not in multiple sclerosis or headache controls. Screening with a protein macroarray led to identification of stress-induced-phosphoprotein-1 (STIP-1) as an antigenic target...
October 28, 2011: Journal of Neuroimmunology
Erdem Tüzün, Erdem Yaka, Luigi Zuliani, Sema Içöz, Bariş Baklan, Omer Birişik, Pinar Kurd, Gülşen Akman-Demir, Angela Vincent, Gülden Akdal
Paraneoplastic limbic encephalitis (PLE) associated with small cell lung cancer (SCLC) often presents with antibodies to intracellular antigens and a poor outcome even after tumor resection and immunotherapy. We report a PLE patient presenting with generalized seizures, shortterm memory impairment and medial temporal lobe hyperintensity in MRI. Initial screening revealed significantly elevated thyroid antibody levels suggesting Hashimoto's encephalopathy. Following methylprednisolone treatment, her seizures ceased, MRI findings disappeared and memory impairment showed a partial resolution in 5 months...
June 2011: Acta Neurologica Belgica
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