keyword
MENU ▼
Read by QxMD icon Read
search

Inflammation, atherosclerosis

keyword
https://www.readbyqxmd.com/read/29045618/cd27-co-stimulation-increases-the-abundance-of-regulatory-t-cells-and-reduces-atherosclerosis-in-hyperlipidaemic-mice
#1
Holger Winkels, Svenja Meiler, Dirk Lievens, David Engel, Charlotte Spitz, Christina Bürger, Linda Beckers, Angelika Dandl, Sigrid Reim, Maiwand Ahmadsei, Helene Hartwig, Lesca M Holdt, Michael Hristov, Remco T A Megens, Martin M Schmitt, Eric A Biessen, Jannie Borst, Alexander Faussner, Christian Weber, Esther Lutgens, Norbert Gerdes
Aims: The co-stimulatory receptor CD27 modulates responses of T cells, B cells, and NK cells. Various T cell subsets participate in atherogenesis. However, the role of CD27 in atherosclerosis remains unexplored. Methods and results: Here we investigated the effect of bone marrow-derived and systemic CD27 deficiency in Apolipoprotein E-deficient (Apoe-/-) mice in early and advanced stages of atherosclerosis. Lethally-irradiated Apoe-/- mice reconstituted with Cd27-/-Apoe-/- bone marrow and consuming an atherogenic diet displayed a markedly increased plaque size and lesional inflammation compared to mice receiving Cd27+/+Apoe-/- bone marrow...
October 16, 2017: European Heart Journal
https://www.readbyqxmd.com/read/29038791/traditional-chinese-medicine-protects-against-cytokine-production-as-the-potential-immunosuppressive-agents-in-atherosclerosis
#2
REVIEW
Yan Ren, Wei Qiao, Dongliang Fu, Zhiwei Han, Wei Liu, Weijie Ye, Zunjing Liu
Atherosclerosis is a chronic inflammatory disease caused by dyslipidemia and mediated by both innate and adaptive immune responses. Inflammation is a critical factor at all stages of atherosclerosis progression. Proinflammatory cytokines accelerate atherosclerosis progression, while anti-inflammatory cytokines ameliorate the disease. Accordingly, strategies to inhibit immune activation and impede immune responses towards anti-inflammatory activity are an alternative therapeutic strategy to conventional chemotherapy on cardiocerebrovascular outcomes...
2017: Journal of Immunology Research
https://www.readbyqxmd.com/read/29038592/in-vivo-imaging-of-lung-inflammation-with-neutrophil-specific-68-ga-nano-radiotracer
#3
Juan Pellico, Ana V Lechuga-Vieco, Elena Almarza, Andrés Hidalgo, Cristina Mesa-Nuñez, Irene Fernández-Barahona, Juan A Quintana, Juan Bueren, Jose A Enríquez, Jesús Ruiz-Cabello, Fernando Herranz
In vivo detection and quantification of inflammation is a major goal in molecular imaging. Furthermore, cell-specific detection of inflammation would be a tremendous advantage in the characterization of many diseases. Here, we show how this goal can be achieved through the synergistic combination of nanotechnology and nuclear imaging. One of the most remarkable features of this hybrid approach is the possibility to tailor the pharmacokinetics of the nanomaterial-incorporated biomolecule and radionuclide. A good example of this approach is the covalent binding of a large amount of a neutrophil-specific, hydrophobic peptide on the surface of (68)Ga core-doped nanoparticles...
October 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29038540/regulation-of-endothelial-intracellular-adenosine-via-adenosine-kinase-epigenetically-modulates-vascular-inflammation
#4
Yiming Xu, Yong Wang, Siyuan Yan, Qiuhua Yang, Yaqi Zhou, Xianqiu Zeng, Zhiping Liu, Xiaofei An, Haroldo A Toque, Zheng Dong, Xuejun Jiang, David J Fulton, Neal L Weintraub, Qinkai Li, Zsolt Bagi, Mei Hong, Detlev Boison, Chaodong Wu, Yuqing Huo
The molecular mechanisms underlying vascular inflammation and associated inflammatory vascular diseases are not well defined. Here we show that endothelial intracellular adenosine and its key regulator adenosine kinase (ADK) play important roles in vascular inflammation. Pro-inflammatory stimuli lead to endothelial inflammation by increasing endothelial ADK expression, reducing the level of intracellular adenosine in endothelial cells, and activating the transmethylation pathway through increasing the association of ADK with S-adenosylhomocysteine (SAH) hydrolase (SAHH)...
October 16, 2017: Nature Communications
https://www.readbyqxmd.com/read/29037856/platelet-cd40-mediates-leukocyte-recruitment-and-neointima-formation-after-arterial-denudation-injury-in-atherosclerosis-prone-mice
#5
Rong Jin, Adam Y Xiao, Zifang Song, Shiyong Yu, Jarvis Li, Mei-Zhen Cui, Guohong Li
The role of platelets in the development of thrombosis and abrupt closure after angioplasty is well recognized. However, the direct impact of platelets on neointima formation after arterial injury remains undetermined. Here we show that neointima formation after carotid artery wire injury reduces markedly in CD40(-/-)apoE(-/-) mice but only slightly in CD40L(-/-)apoE(-/-) mice, compared with apolipoprotein E-deficient (apoE(-/-)) mice. Wild-type and CD40-deficient platelets were isolated from blood of apoE(-/-) and CD40(-/-)apoE(-/-) mice, respectively...
October 13, 2017: American Journal of Pathology
https://www.readbyqxmd.com/read/29035781/lack-of-myeloid-fatp1-increases-atherosclerotic-lesion-size-in-ldlr-mice
#6
Liyang Zhao, Alyssa J Cozzo, Amy R Johnson, Taylor Christensen, Alex J Freemerman, James E Bear, Jeremy D Rotty, Brian J Bennett, Liza Makowski
BACKGROUND AND AIMS: Altered metabolism is an important regulator of macrophage (MΦ) phenotype, which contributes to inflammatory diseases such as atherosclerosis. Broadly, pro-inflammatory, classically-activated MΦs (CAM) are glycolytic while alternatively-activated MΦs (AAM) oxidize fatty acids, although overlap exists. We previously demonstrated that MΦ fatty acid transport protein 1 (FATP1, Slc27a1) was necessary to maintain the oxidative and anti-inflammatory AAM phenotype in vivo in a model of diet-induced obesity...
October 7, 2017: Atherosclerosis
https://www.readbyqxmd.com/read/29035165/development-of-highly-sensitive-cell-based-akt-kinase-elisa-for-monitoring-pi3k-beta-activity-and-compound-efficacy
#7
Mahesh Yanamandra, Labanyamoy Kole, Archana Giri, Sayan Mitra
Phosphatidylinositol-3 kinase pathway regulates multiple cellular function involving cell survival, growth, motility proliferation, apoptosis, and adhesion. These are deregulated in various diseases like cancer, atherosclerosis, and inflammation. PI3Ks phosphorylate phosphatidylinositol 4,5 biphosphate (PIP2) yielding phosphatidylinositol 3, 4, 5 triphosphate (PIP3) that in turn activates AKT kinase (serine/threonine kinase) which is the central enzyme in regulation of metabolic functions. Due to their implications in disease pathophysiology, PI3K/AKT inhibitors became attractive targets for pharmaceutical industries...
October 16, 2017: Journal of Immunoassay & Immunochemistry
https://www.readbyqxmd.com/read/29034031/coronary-artery-bypass-surgery-in-end-stage-renal-disease-patients
#8
REVIEW
Daijiro Hori, Atsushi Yamaguchi, Hideo Adachi
The number of patients requiring hemodialysis is continuously increasing around the world. Hemodialysis affects patient quality of life and it is also associated with a higher risk for cardiovascular events. In addition to traditional risk factors for cardiovascular events such as hypertension, hyperlipidemia, and diabetes, hemodialysis is associated with hyperphosphatemia, chronic inflammation, vascular calcification, and anemia which accelerate atherosclerosis, vascular stiffness, and cardiac ischemia. Treatment strategy for coronary revascularization in this progressive disease remains controversial...
June 25, 2017: Annals of Vascular Diseases
https://www.readbyqxmd.com/read/29032752/association-between-apolipoproteins-ai-and-b-and-ultrasound-indicators-of-carotid-atherosclerosis
#9
Zeljko Zivanovic, Ivana Divjak, Mirjana Jovicevic, Tamara Rabi-Zikic, Biljana Radovanovic, Svetlana Ruzicka-Kaloci, Djordje Stevan Popovic, Edita Stokic, Ksenija Gebauer-Bukurov, Katarina Zivanovic-Vujcic, Petar Slankamenac
BACKGROUND: Apolipoproteins A-I and B (apoA-I and apoB) may be better indicators of the risk of cardiovascular and cerebrovascular diseases than conventional risk factors (RFs). The onset of ischemic stroke (IS) may be preceded by the development of atherosclerotic changes in carotid arteries, which can be detected by ultrasound. Only a certain % of patients with IS have an (underlying) carotid etiology. OBJECTIVE: The aim of our study was to determine the association between ultrasound indicators of carotid atherosclerosis and the presence of apolipoproteins and other biomarkers in patients with IS...
October 10, 2017: Current Vascular Pharmacology
https://www.readbyqxmd.com/read/29032340/quinic-acid-inhibits-vascular-inflammation-in-tnf-%C3%AE-stimulated-vascular-smooth-muscle-cells
#10
Seon-A Jang, Dae Won Park, Jeong Eun Kwon, Hae Seong Song, Bongkyun Park, Hyelin Jeon, Eun-Hwa Sohn, Hyun Jung Koo, Se Chan Kang
Atherosclerosis is a chronic inflammatory disease, and the increased expression of adhesion molecules on vascular smooth muscle cells contributes to the progression of vascular disease. Quinic acid (QA) has been shown to possess radioprotection, anti-neuroinflammatory, and anti-oxidant activities; however, an anti-vascular inflammatory effect has not been reported. This study investigated the effect of QA on the expression of vascular cell adhesion molecule-1 (VCAM-1) stimulated by TNF-α in MOVAS cells. Pre-incubation of MOVAS cells, the mouse vascular smooth muscle cell line for 2h with QA (0...
October 12, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29032330/biofabricating-atherosclerotic-plaques-in%C3%A2-vitro-engineering-of-a-three-dimensional-human-fibroatheroma-model
#11
Anna Mallone, Chantal Stenger, Arnold Von Eckardstein, Simon P Hoerstrup, Benedikt Weber
Atherosclerotic plaques are cholesterol-induced inflammatory niches accumulating in the vascular sub-endothelial space. Cellular and extracellular composition of human plaques is maneuvered by local inflammation that leads to alterations in the original vascular microenvironment and to the recruitment of an invading fibrous layer (fibroatharoma). In the present study we introduce a bioengineered three-dimensional model of human fibroatheroma (ps-plaque) assembled with a tailored hanging-drop protocol. Using vi-SNE based multidimensional flow cytometry data analysis we compared the myeloid cell-populations in ps-plaques to those in plaques isolated from human carotid arteries...
September 28, 2017: Biomaterials
https://www.readbyqxmd.com/read/29030487/macrophage-specific-expression-of-il-37-in-hyperlipidemic-mice-attenuates-atherosclerosis
#12
Sara McCurdy, Yvonne Baumer, Emma Toulmin, Bog-Hieu Lee, William A Boisvert
Atherosclerosis, the progressive buildup of plaque within arterial blood vessels, can lead to fatal downstream events, such as heart attack or stroke. A key event contributing to the development of atherosclerosis is the infiltration of monocytes and its associated inflammation, as well as the formation of lipid-laden macrophage foam cells within the vessel wall. IL-37 is recognized as an important anti-inflammatory cytokine expressed especially by immune cells. This study was undertaken to elucidate the role of macrophage-expressed IL-37 in reducing the production and effects of proinflammatory cytokines, preventing foam cell formation, and reducing the development of atherosclerosis...
October 13, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/29029593/lymphatic-dysfunction-leukotrienes-and-lymphedema
#13
Xinguo Jiang, Mark R Nicolls, Wen Tian, Stanley G Rockson
The lymphatic system is essential for the maintenance of tissue fluid homeostasis, gastrointestinal lipid absorption, and immune trafficking. Whereas lymphatic regeneration occurs physiologically in wound healing and tissue repair, pathological lymphangiogenesis has been implicated in a number of chronic diseases such as lymphedema, atherosclerosis, and cancer. Insight into the regulatory mechanisms of lymphangiogenesis and the manner in which uncontrolled inflammation promotes lymphatic dysfunction is urgently needed to guide the development of novel therapeutics: These would be designed to reverse lymphatic dysfunction, either primary or acquired...
October 13, 2017: Annual Review of Physiology
https://www.readbyqxmd.com/read/29028081/serum-ykl-40-level-is-correlated-with-apnea-hypopnea-index-in-patients-with-obstructive-sleep-apnea-sindrome
#14
L C Mutlu, F Tülübaş, R Alp, G Kaplan, Z D Yildiz, A Gürel
OBJECTIVE: Obstructive sleep apnea syndrome (OSAS) has been associated with elevated biochemical markers of inflammation. Although the exact mechanism is unknown, both sleep deprivation and hypoxemia are believed to be important causative factors. YKL-40, also known as chitinase-like protein, has been shown to be related to various inflammatory conditions including atherosclerosis, diabetes, cancer, and asthma. The present study aimed to evaluate the relationship between YKL-40 levels and the Apnea Hypopnea Index (AHI) in patients with obstructive sleep apnea syndrome...
September 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29026413/evaluation-of-pentraxin-3-level-and-its-related-factors-in-patients-undergoing-primary-percutaneous-coronary-intervention
#15
Saeed Alipour-Parsa, Habib Haybar, Mohammad Hasan Namazi, Morteza Safi, Isa Khaheshi, Mehdi Memaryan, Amir Mohammad Eghbalnejad-Mofrad
BACKGROUND: Inflammation has an important role in the development and progression of atherosclerosis, and acute phase proteins such as pentraxin-3 (PTX3) can be deployed in determining the prognosis of coronary artery disease (CAD). So the purpose of this paper was to evaluate the PTX3 level and its related factors in patients undergoing primary percutaneous coronary intervention (PCI). METHODS: In this cross-sectional study, the PTX3 levels were determined for 100 patients with ST-elevation myocardial infarction referred to the Modarres Hospital, Tehran, Iran...
March 2017: ARYA Atherosclerosis
https://www.readbyqxmd.com/read/29025405/the-anti-inflammatory-function-of-hdl-is-impaired-in-type-2-diabetes-role-of-hyperglycemia-paraoxonase-1-and-low-grade-inflammation
#16
Sanam Ebtehaj, Eke G Gruppen, Mojtaba Parvizi, Uwe J F Tietge, Robin P F Dullaart
BACKGROUND: Functional properties of high density lipoproteins (HDL) are increasingly recognized to play a physiological role in atheroprotection. Type 2 diabetes mellitus (T2DM) is characterized by low HDL cholesterol, but the effect of chronic hyperglycemia on the anti-inflammatory capacity of HDL, a metric of HDL function, is unclear. Therefore, the aim of the present study was to establish the impact of T2DM on the HDL anti-inflammatory capacity, taking paraoxonase-1 (PON-1) activity and low grade inflammation into account...
October 12, 2017: Cardiovascular Diabetology
https://www.readbyqxmd.com/read/29024702/polycystic-ovarian-syndrome-pcos-long-term-metabolic-consequences
#17
Panagiotis Anagnostis, Basil C Tarlatzis, Robert P Kauffman
Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in women during their reproductive ages, associated with a plethora of cardiometabolic consequences, with obesity, insulin resistance and hyperandrogenemia playing a major role in the degree of such manifestations. These consequences include increased risk of glucose intolerance and diabetes mellitus (both type 2 and gestational), atherogenic dyslipidemia, systemic inflammation, non-alcoholic fatty liver disease, hypertension and coagulation disorders...
October 9, 2017: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/29023363/lps-induced-systemic-inflammation-does-not-alter-atherosclerotic-plaque-area-or-inflammation-in-apoe3-leiden-mice-in-the-early-phase-up-to-15-days
#18
Wessel W Fuijkschot, Martine C Morrison, Ilse P A Zethof, Paul A J Krijnen, Robert Kleemann, Hans W M Niessen, Yvo M Smulders
BACKGROUND AND AIMS: Observational studies show a peak incidence in cardiovascular events during and early after clinical conditions associated with substantial systemic inflammation, such as pneumonia. The acuteness of this increased risk suggests rapid plaque destabilization and associated intra-plaque inflammation. We evaluated whether LPS-evoked acute systemic inflammation would induce such detrimental vascular changes in murine aortas with manifest atherosclerotic lesions. METHODS AND RESULTS: ApoE3*Leiden mice were fed a high cholesterol diet for 20 weeks to establish atherosclerosis...
October 11, 2017: Shock
https://www.readbyqxmd.com/read/29022506/autologous-cell-therapy-for-vascular-regeneration-the-role-of-proangiogenic-cells
#19
Vanessa Bianconi, Francesca Fallarino, Massimo Raffaele Mannarino, Francesco Bagaglia, Meisam Naeimi Kararoudi, Caterina Oriana Aragona, Rita Romani, Matteo Pirro
Autologous cell therapy represents a novel treatment option for vascular regeneration in different disease conditions. Both experimental and clinical studies indicate a therapeutic potential for different proangiogenic cells (PCs), including endothelial progenitor cells (EPCs) in the treatment of peripheral artery disease. A significant improvement of ischemic symptoms has been reported in different trials evaluating PCs for the treatment of critical limb ischemia. However, contrasting results from different meta-analyses question the efficacy of PC-based approaches on long-term outcomes, including amputation and survival...
October 12, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/29022053/glycated-albumin-ga-and-inflammation-role-of-ga-as-a-potential-marker-of-inflammation
#20
REVIEW
H Vernon Roohk, Asad R Zaidi, Dimple Patel
AIMS: Abnormal levels of glycated albumin (GA) are associated with the onset of both diabetes and inflammation. Although inflammation has long been associated with diabetes, this article aims to explore the underlying mechanisms of this relationship as it pertains to the role of GA. METHODS: We have reviewed 52 research articles since the year 2000. Common search terms used were "(inflammatory mediator) and GA" or "inflammation and GA". The findings have been organized according to diabetic complications with respect to the interactions of GA and inflammatory mediators...
October 11, 2017: Inflammation Research: Official Journal of the European Histamine Research Society ... [et Al.]
keyword
keyword
20781
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"