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https://www.readbyqxmd.com/read/29334615/hemodynamic-and-metabolic-responses-to-self-paced-and-ramp-graded-exercise-testing-protocols
#1
Nicholas M Beltz, Fabiano Amorim, Ann L Gibson, Jeffrey M Janot, Len Kravitz, Christine M Mermier, Nathan Cole, Terence A Moriarty, Tony P Nunez, Sam Trigg, Lance Dalleck
PURPOSE: Recent examinations have shown lower maximal oxygen uptake (VO2max) during traditional ramp (RAMP) compared to self-paced (SPV) graded exercise testing (GXT) attributed to differences in cardiac ouput. The current study examined the differences in hemodyamic and metabolic responses between RAMP and SPV during treadmill exercise. METHODS: Sixteen recreationally trained men (23.7±3.0 yrs) completed two separate treadmill GXT protocols. SPV consisted of five 2-min stages (10 min total) of increasing speed clamped by the Borg RPE6-20 scale...
January 15, 2018: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
https://www.readbyqxmd.com/read/29334380/light-activated-chemical-probing-of-nucleobase-solvent-accessibility-inside-cells
#2
Chao Feng, Dalen Chan, Jojo Joseph, Mikko Muuronen, William H Coldren, Nan Dai, Ivan R Corrêa, Filipp Furche, Christopher M Hadad, Robert C Spitale
The discovery of functional RNAs that are critical for normal and disease physiology continues to expand at a breakneck pace. Many RNA functions are controlled by the formation of specific structures, and an understanding of each structural component is necessary to elucidate its function. Measuring solvent accessibility intracellularly with experimental ease is an unmet need in the field. Here, we present a novel method for probing nucleobase solvent accessibility, Light Activated Structural Examination of RNA (LASER)...
January 15, 2018: Nature Chemical Biology
https://www.readbyqxmd.com/read/29332817/miniaturised-electrically-actuated-high-pressure-injection-valve-for-portable-capillary-liquid-chromatography
#3
Yan Li, Kirsten Pace, Pavel N Nesterenko, Brett Paull, Roger Stanley, Mirek Macka
A miniaturised high pressure 6-port injection valve has been designed and evaluated for its performance in order to facilitate the development of portable capillary high performance liquid chromatography (HPLC). The electrically actuated valve features a very small size (65 × 19 × 19mm) and light weight (33g), and therefore can be easily integrated in a miniaturised modular capillary LC system suited for portable field analysis. The internal volume of the injection valve was determined as 98 nL. The novel conical shape of the stator and rotor and the spring-loaded rotor performed well up to 32MPa (4641psi), the maximum operating pressure investigated...
April 1, 2018: Talanta
https://www.readbyqxmd.com/read/29331720/temporal-spatial-gait-parameter-models-of-very-slow-walking
#4
Andrew J J Smith, Edward D Lemaire
This study assessed the relationship between walking speed and common temporal-spatial stride-parameters to determine if a change in gait strategy occurs at extremely slow walking speeds. Stride-parameter models that represent slow walking can act as a reference for lower extremity exoskeleton and powered orthosis controls since these devices typically operate at walking speeds less than 0.4 m/s. Full-body motion capture data were collected from 30 health adults while walking on a self-paced treadmill, within a CAREN-Extended virtual reality environment...
January 6, 2018: Gait & Posture
https://www.readbyqxmd.com/read/29331571/interdepartmental-imaging-protocol-for-clinically-based-three-dimensional-computed-tomography-can-provide-accurate-measurement-of-glenoid-version
#5
Connor L Zale, Gregory I Pace, Gregory S Lewis, John Chan, H Mike Kim
BACKGROUND: Conventional computed tomography (CT) is not accurate for glenoid version measurement. This study sought to examine the feasibility of an interdepartmental protocol implemented between orthopedic surgery and radiology departments for acquisition of anatomic axial CT images and to validate the glenoid version measured through such a protocol. MATERIALS AND METHODS: Data of 30 conventional CT scans of 10 normal and 20 osteoarthritic glenoids were transferred to clinical 3-dimensional imaging software by a radiology technician trained for the study...
January 10, 2018: Journal of Shoulder and Elbow Surgery
https://www.readbyqxmd.com/read/29331490/supervised-machine-learning-for-population-genetics-a-new-paradigm
#6
REVIEW
Daniel R Schrider, Andrew D Kern
As population genomic datasets grow in size, researchers are faced with the daunting task of making sense of a flood of information. To keep pace with this explosion of data, computational methodologies for population genetic inference are rapidly being developed to best utilize genomic sequence data. In this review we discuss a new paradigm that has emerged in computational population genomics: that of supervised machine learning (ML). We review the fundamentals of ML, discuss recent applications of supervised ML to population genetics that outperform competing methods, and describe promising future directions in this area...
January 10, 2018: Trends in Genetics: TIG
https://www.readbyqxmd.com/read/29330131/response-of-human-induced-pluripotent-stem-cell-derived-cardiomyocytes-to-several-pharmacological-agents-when-intrinsic-syncytial-pacing-is-overcome-by-acute-external-stimulation
#7
Haoyu Zeng, Bharathi Balasubramanian, Armando Lagrutta, Frederick Sannajust
We challenged human induced pluripotent stem cell-derived cardiomyocyte (hiPSC-CM) syncytia, mainly, CDI iCells with several classes of well-characterized pharmacological agents (including hERG blocker, Nav1.5 blocker, Cav1.2 blocker and opener, β-adrenergic agonist, and If blocker) under pacing conditions, utilizing the Cardio-ECR instrument, a non-invasive platform featuring simultaneous and continuous measurement of synchronized beating rate and contractility (both signals were acquired simultaneously and well aligned) ...
January 9, 2018: Journal of Pharmacological and Toxicological Methods
https://www.readbyqxmd.com/read/29328900/detecting-and-managing-device-leads-inadvertently-placed-in-the-left-ventricle
#8
REVIEW
Richard G Trohman, Parikshit S Sharma
Inadvertent malpositioning of a cardiac implantable electronic device lead into the left ventricle is a rare complication of transvenous pacing and defibrillation. Rapid identification of lead position is critical during implantation and just after the procedure, with immediate correction required if malpositioning is detected. If lead misplacement is discovered late after implantation, the lead should be surgically removed or chronic anticoagulation with warfarin should be instituted.
January 2018: Cleveland Clinic Journal of Medicine
https://www.readbyqxmd.com/read/29328532/population-genomic-footprints-of-host-adaptation-introgression-and-recombination-in-coffee-leaf-rust
#9
Diogo Nuno Silva, Vítor Várzea, Octávio Salgueiro Paulo, Dora Batista
Coffee Leaf Rust, caused by Hemileia vastatrix (Hv), represents the biggest threat to coffee production worldwide and ranks amongst the most serious fungal diseases in history. Despite a recent series of outbreaks and emergence of hyper-virulent strains, the population evolutionary history and potential of this pathogen remains poorly understood. To address this issue, we used RADseq to generate ∼19,000 SNPs across a worldwide collection of 37 Hv samples. Contrarily to the longstanding idea that Hv represents a genetically unstructured and cosmopolitan species, our results reveal the existence of a cryptic species complex with marked host tropism...
January 12, 2018: Molecular Plant Pathology
https://www.readbyqxmd.com/read/29327704/emerging-nonmetabolic-functions-of-skin-fat
#10
REVIEW
Christian F Guerrero-Juarez, Maksim V Plikus
Although the major white adipose depots evolved primarily to store energy, secrete hormones and thermo-insulate the body, multiple secondary depots developed additional specialized and unconventional functions. Unlike any other fat tissue, dermal white adipose tissue (dWAT) evolved a large repertoire of novel features that are central to skin physiology, which we discuss in this Review. dWAT exists in close proximity to hair follicles, the principal appendages of the skin that periodically grow new hairs. Responding to multiple hair-derived signals, dWAT becomes closely connected to cycling hair follicles and periodically cycles itself...
January 12, 2018: Nature Reviews. Endocrinology
https://www.readbyqxmd.com/read/29327439/the-hidden-concealed-left-sided-accessory-pathway-an-uncommon-cause-of-svt-in-young-people
#11
Robert H Pass, Leonardo Liberman, Eric S Silver, Christopher M Janson, Andrew D Blaufox, Lynn Nappo, Scott R Ceresnak
BACKGROUND: Concealed left sided accessory pathways (CLAP) are a cause of SVT in the young. Most are mapped with RV apical/outflow pacing. Rarely, alternative means of mapping are required. We review our experience from 3 pediatric EP centers with a rare form of "hidden" CLAP. METHODS: All patients < 21 years undergoing EP study from 2008-2014 with a "hidden" CLAP (defined as an accessory pathway (AP) for which RV pacing at CL's stable for mapping did not demonstrate eccentric retrograde conduction) were included...
January 12, 2018: Pacing and Clinical Electrophysiology: PACE
https://www.readbyqxmd.com/read/29327371/variable-degrees-of-ventricular-preexcitation-during-rapid-atrial-pacing-what-is-the-mechanism
#12
Taihei Itoh, Takumi Yamada
No abstract text is available yet for this article.
January 12, 2018: Pacing and Clinical Electrophysiology: PACE
https://www.readbyqxmd.com/read/29327140/children-s-experiences-of-congenital-heart-disease-a-systematic-review-of-qualitative-studies
#13
REVIEW
Lauren S H Chong, Dominic A Fitzgerald, Jonathan C Craig, Karine E Manera, Camilla S Hanson, David Celermajer, Julian Ayer, Nadine A Kasparian, Allison Tong
We aimed to describe the experiences of children and adolescents with congenital heart disease (CHD). Electronic databases were searched until August 2016. Qualitative studies of children's perspectives on CHD were included. Data was extracted using thematic synthesis. From 44 studies from 12 countries involving 995 children, we identified 6 themes: disrupting normality (denying the diagnosis, oscillating between sickness and health, destabilizing the family dynamic), powerlessness in deteriorating health (preoccupation with impending mortality, vulnerability to catastrophic complications, exhaustion from medical testing), enduring medical ordeals (traumatized by invasive procedures, disappointed by treatment failure, displaced by transition, valuing empathy and continuity in care, overcoming uncertainty with information), warring with the body (losing stamina, distressing inability to participate in sport, distorted body image, testing the limits), hampering potential and goals (feeling disabled, unfair judgment and exclusion, difficulties with academic achievement, limiting attainment and maintenance of life milestones), and establishing one's own pace (demarcating disease from life, determination to survive, taking limitations in their stride, embracing the positives, finding personal enrichment, relying on social or spiritual support)...
January 11, 2018: European Journal of Pediatrics
https://www.readbyqxmd.com/read/29326829/choice-of-ventricular-pacing-site-the-end-of-non-physiological-apical-ventricular-pacing
#14
Demosthenes G Katritsis
No abstract text is available yet for this article.
December 2017: Arrhythmia & Electrophysiology Review
https://www.readbyqxmd.com/read/29326416/strategies-to-restore-adenosine-triphosphate-atp-level-after-more-than-20-hours-of-cold-ischemia-time-in-human-marginal-kidney-grafts
#15
Matteo Ravaioli, Maurizio Baldassare, Francesco Vasuri, Gianandrea Pasquinelli, Maristella Laggetta, Sabrina Valente, Vanessa De Pace, Flavia Neri, Antonio Siniscalchi, Chiara Zanfi, Valentina R Bertuzzo, Paolo Caraceni, Davide Trerè, Pasquale Longobardi, Antonio D Pinna
BACKGROUND The persisting organ shortage in the field of transplantation recommends the use of marginal kidneys which poorly tolerate ischemic damage. Adenosine triphosphate (ATP) depletion during cold ischemia time (CIT) is considered crucial for graft function. We tested different strategies of kidney perfusion before transplantation in the attempt to improve the technique. MATERIAL AND METHODS Twenty human discarded kidneys from donors after brain death and with at least 20 hours of CIT were randomized to the following experimental groups (treatment time three-hours at 4°C): a) static cold storage (CS); b) static cold hyperbaric oxygenation (Hyp); c) hypothermic perfusion (PE); d) hypothermic perfusion in hyperbaric oxygenation (PE-Hyp); and e) hypothermic oxygenated perfusion (PE-O2)...
January 12, 2018: Annals of Transplantation: Quarterly of the Polish Transplantation Society
https://www.readbyqxmd.com/read/29326266/the-epigenetic-control-of-stemness-in-cd8-t-cell-fate-commitment
#16
Luigia Pace, Christel Goudot, Elina Zueva, Paul Gueguen, Nina Burgdorf, Joshua J Waterfall, Jean-Pierre Quivy, Geneviève Almouzni, Sebastian Amigorena
After priming, naïve CD8+ T lymphocytes establish specific heritable transcription programs that define progression to long-lasting memory cells or to short-lived effector cells. Although lineage specification is critical for protection, it remains unclear how chromatin dynamics contributes to the control of gene expression programs. We explored the role of gene silencing by the histone methyltransferase Suv39h1. In murine CD8+ T cells activated after Listeria monocytogenes infection, Suv39h1-dependent trimethylation of histone H3 lysine 9 controls the expression of a set of stem cell-related memory genes...
January 12, 2018: Science
https://www.readbyqxmd.com/read/29326129/machine-learning-algorithm-predicts-cardiac-resynchronization-therapy-outcomes-lessons-from-the-companion-trial
#17
Matthew M Kalscheur, Ryan T Kipp, Matthew C Tattersall, Chaoqun Mei, Kevin A Buhr, David L DeMets, Michael E Field, Lee L Eckhardt, C David Page
BACKGROUND: Cardiac resynchronization therapy (CRT) reduces morbidity and mortality in heart failure patients with reduced left ventricular function and intraventricular conduction delay. However, individual outcomes vary significantly. This study sought to use a machine learning algorithm to develop a model to predict outcomes after CRT. METHODS AND RESULTS: Models were developed with machine learning algorithms to predict all-cause mortality or heart failure hospitalization at 12 months post-CRT in the COMPANION trial (Comparison of Medical Therapy, Pacing, and Defibrillation in Heart Failure)...
January 2018: Circulation. Arrhythmia and Electrophysiology
https://www.readbyqxmd.com/read/29325977/role-of-apamin-sensitive-small-conductance-calcium-activated-potassium-currents-in-long-term-cardiac-memory-in-rabbits
#18
Dechun Yin, Mu Chen, Na Yang, Adonis Z Wu, Dongzhu Xu, Wei-Chung Tsai, Yuan Yuan, Zhipeng Tian, Yi-Hsin Chan, Changyu Shen, Zhenhui Chen, Shien-Fong Lin, James N Weiss, Peng-Sheng Chen, Thomas H Everett
BACKGROUND: Apamin-sensitive small conductance calcium-activated K current (IKAS) is upregulated during ventricular pacing and masks short-term cardiac memory (CM). OBJECTIVE: - To determine the role of IKAS in long-term CM. METHODS: - CM was created with 3-5 weeks of ventricular pacing and defined by a flat or inverted T-wave off pacing. Epicardial optical mapping was performed in both paced and normal ventricles. Action potential duration (APD80) was determined during RA pacing...
January 8, 2018: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/29325638/implantable-cardioverter-defibrillators-in%C3%A2-children-and-adolescents-with-brugada%C3%A2-syndrome
#19
M Cecilia Gonzalez Corcia, Juan Sieira, Gudrun Pappaert, Carlo de Asmundis, Gian Battista Chierchia, Mark La Meir, Andrea Sarkozy, Pedro Brugada
BACKGROUND: Young patients presenting with symptomatic Brugada syndrome have very high risks for ventricular arrhythmias and should be carefully considered for implantable cardioverter-defibrillator (ICD) placement. However, this therapy is associated with high rates of inappropriate shocks and device-related complications. OBJECTIVES: This study investigated clinical features, management, and long-term follow-up of young patients with Brugada syndrome and ICD. METHODS: Patients diagnosed with Brugada syndrome, who underwent implantation of an ICD at an age of ≤20 years, were studied...
January 16, 2018: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/29325242/-keep-pace-with-the-time-do-our-best-in-pathology
#20
J Chen
No abstract text is available yet for this article.
January 8, 2018: Zhonghua Bing Li Xue za Zhi Chinese Journal of Pathology
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