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https://www.readbyqxmd.com/read/28636524/his-bundle-pacing-using-dual-chamber-cardioverter-defibrillator-in-patients-with-chronic-atrial-fibrillation-different-pacing-and-sensing-features
#1
Agnieszka Sławuta, Dariusz Biały, Dorota Zyśko, Grzegorz Mazur, Jacek Gajek
No abstract text is available yet for this article.
March 31, 2017: Acta Cardiologica
https://www.readbyqxmd.com/read/28634048/activation-volume-vs-bold-signal-change-as-measures-of-fmri-activation-its-impact-on-gaba-fmri-activation-correlation
#2
Pallab K Bhattacharyya, Micheal D Phillips, Lael A Stone, Mark J Lowe
PURPOSE: To explore the relative robustness of functional MRI (fMRI) activation volume and blood oxygen level-dependent (BOLD) signal change as fMRI metric, and to study the effect of relative robustness on the correlation between fMRI activation and cortical gamma amino butyric acid (GABA) in healthy controls and patients with multiple sclerosis (MS). METHODS: fMRI data were acquired from healthy controls and patients with MS, with the subjects peforming self paced bilateral finger tapping in block design...
June 17, 2017: Magnetic Resonance Imaging
https://www.readbyqxmd.com/read/28633659/computing-patient-data-in-the-cloud-practical-and-legal-considerations-for-genetics-and-genomics-research-in-europe-and-internationally
#3
Fruzsina Molnár-Gábor, Rupert Lueck, Sergei Yakneen, Jan O Korbel
Biomedical research is becoming increasingly large-scale and international. Cloud computing enables the comprehensive integration of genomic and clinical data, and the global sharing and collaborative processing of these data within a flexibly scalable infrastructure. Clouds offer novel research opportunities in genomics, as they facilitate cohort studies to be carried out at unprecedented scale, and they enable computer processing with superior pace and throughput, allowing researchers to address questions that could not be addressed by studies using limited cohorts...
June 20, 2017: Genome Medicine
https://www.readbyqxmd.com/read/28633339/will-electronic-health-record-data-become-the-standard-resource-for-clinical-research
#4
Jeffrey F Scherrer, Wilson D Pace
No abstract text is available yet for this article.
June 14, 2017: Family Practice
https://www.readbyqxmd.com/read/28632322/reduced-intensity-conditioning-allogeneic-transplantation-after-salvage-treatment-with-dt-pace-in-myeloma-patients-relapsing-early-after-autologous-transplant
#5
K Randall, M Kaparou, E Xenou, S Paneesha, B Kishore, A Kanellopoulos, R Lovell, K Holder, J Suhr, L Baker, L Ryan, E Nikolousis
OBJECTIVE: In this retrospective single center study we have looked into the transplant outcomes(overall survival OS, progression free survival PFS,GvHD) and the role of chimerism, DLI and pre-transplant characteristics in patients who had a suboptimal response (<12 months)to an autologous stem cell transplant for myeloma and underwent an Alemtuzumab T-cell depleted reduced intensity allograft(RIC). METHODS: 24 patients were salvaged with 2 cycles of DT-PACE and received a RIC transplant with Fludarabine, Melphalan and Alemtuzumab...
June 20, 2017: European Journal of Haematology
https://www.readbyqxmd.com/read/28632278/paper-microfluidics-for-nucleic-acid-amplification-testing-naat-of-infectious-diseases
#6
Laura Magro, Camille Escadafal, Pierre Garneret, Béatrice Jacquelin, Aurélia Kwasiborski, Jean-Claude Manuguerra, Fabrice Monti, Anavaj Sakuntabhai, Jessica Vanhomwegen, Pierre Lafaye, Patrick Tabeling
The diagnosis of infectious diseases is entering a new and interesting phase. Technologies based on paper microfluidics, coupled to developments in isothermal amplification of Nucleic Acids (NAs) raise opportunities for bringing the methods of molecular biology in the field, in a low setting environment. A lot of work has been performed in the domain over the last few years and the landscape of contributions is rich and diverse. Most often, the level of sample preparation differs, along with the sample nature, the amplification and detection methods, and the design of the device, among other features...
June 20, 2017: Lab on a Chip
https://www.readbyqxmd.com/read/28631799/droplet-control-technologies-for-microfluidic-high-throughput-screening-%C3%AE-hts
#7
REVIEW
Muhsincan Sesen, Tuncay Alan, Adrian Neild
The transition from micro well plate and robotics based high throughput screening (HTS) to chip based screening has already started. This transition promises reduced droplet volumes thereby decreasing the amount of fluids used in these studies. Moreover, it significantly boosts throughput allowing screening to keep pace with the overwhelming number of molecular targets being discovered. In this review, we analyse state-of-the-art droplet control technologies that exhibit potential to be used in this new generation of screening devices...
June 20, 2017: Lab on a Chip
https://www.readbyqxmd.com/read/28630581/5000-meter-run-performance-is-not-enhanced-24-hrs-after-an-intense-exercise-bout-and-cold-water-immersion
#8
Mary C Stenson, Matthew R Stenson, Tracey D Matthews, Vincent J Paolone
Cold water immersion (CWI) is used by endurance athletes to speed recovery between exercise bouts, but little evidence is available on the effects of CWI on subsequent endurance performance. The purpose of this study was to investigate the effects of CWI following an acute bout of interval training on 5000 m run performance 24 hrs after interval training, perceived muscle soreness (PMS), range of motion (ROM), thigh circumference (TC), and perceived exertion (RPE). Nine endurance-trained males completed 2 trials, each consisting of an interval training session of 8 repetitions of 1200 m at a running pace equal to 75% of VO2peak, either a control or CWI treatment, and a timed 5000 m run 24 hrs post interval training session...
June 2017: Journal of Sports Science & Medicine
https://www.readbyqxmd.com/read/28630405/sex-differences-in-prostaglandin-biosynthesis-in-neutrophils-during-acute-inflammation
#9
Simona Pace, Antonietta Rossi, Verena Krauth, Friederike Dehm, Fabiana Troisi, Rossella Bilancia, Christina Weinigel, Silke Rummler, Oliver Werz, Lidia Sautebin
The severity and course of inflammatory processes differ between women and men, but the biochemical mechanisms underlying these sex differences are elusive. Prostaglandins (PG) and leukotrienes (LT) are lipid mediators linked to inflammation. We demonstrated superior LT biosynthesis in human neutrophils and monocytes, and in mouse macrophages from females, and we confirmed these sex differences in vivo where female mice produced more LTs during zymosan-induced peritonitis versus males. Here, we report sex differences in PG production in neutrophils during acute inflammation...
June 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28630373/incidence-and-time-course-for-developing-heart-failure-with-high-burden-right-ventricular-pacing
#10
Faisal M Merchant, Michael H Hoskins, Dan L Musat, Julie B Prillinger, Gregory J Roberts, Yelena Nabutovsky, Suneet Mittal
BACKGROUND: Although right ventricular pacing can contribute to cardiomyopathy, the impact of complete atrioventricular block (cAVB) on heart failure (HF) development in pacemaker patients has not been well characterized. We evaluated the incidence and time course for developing HF after pacemaker implantation for cAVB. METHODS AND RESULTS: A MarketScan database identified patients undergoing dual-chamber pacemaker implantation from 2008 to 2014. Patients with cAVB were identified by an atrioventricular node ablation or diagnosis of third-degree AVB...
June 2017: Circulation. Cardiovascular Quality and Outcomes
https://www.readbyqxmd.com/read/28630244/a-case-of-recurrent-multifocal-anastomosing-haemangiomas
#11
Kirsteen R Burton, Kiran Jakate, Kenneth T Pace, Paraskevi A Vlachou
Anastomosing haemangiomas are relatively rare lesions, with a renal predilection, and which, given their imaging and pathologic appearance, mimic aggressive malignancies such as angiosarcoma. The imaging characteristics of this case are informative when evaluating a vascular lesion of the adrenal gland.
June 18, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28630174/experimental-pathologic-and-clinical-findings-of-radiofrequency-catheter-ablation-of-para-hisian-region-from-the-right-ventricle-in-dogs-and-humans
#12
Yumei Xue, Xianzhang Zhan, Shulin Wu, Hongyue Wang, Yang Liu, Zili Liao, Hai Deng, Xuejing Duan, Shaoying Zeng, Dongpo Liang, Arif Elvan, Xianhong Fang, Hongtao Liao, Anand R Ramdat Misier, Jaap Jan J Smit, Andreas Metzner, Christian-Hendrik Heeger, Fangzhou Liu, Feng Wang, Zhiwei Zhang, Karl-Heinz Kuck, Siew Yen Ho, Feifan Ouyang
BACKGROUND: Ablation of para-Hisian accessory pathway (AP) poses high risks of atrioventricular block. We developed a pacing technique to differentiate the near-field (NF) from far-field His activations to avoid the complication. METHODS AND RESULTS: Three-dimensional mapping of the right ventricle was performed in 15 mongrel dogs and 23 patients with para-Hisian AP. Using different pacing outputs, the NF- and far-field His activation was identified on the ventricular aspect...
June 2017: Circulation. Arrhythmia and Electrophysiology
https://www.readbyqxmd.com/read/28630001/host-influence-in-the-genomic-composition-of-flaviviruses-a-multivariate-approach
#13
Diego Simón, Alvaro Fajardo, Martín Sóñora, Adriana Delfraro, Héctor Musto
Flaviviruses present substantial differences in their host range and transmissibility. We studied the evolution of base composition, dinucleotide biases, codon usage and amino acid frequencies in the genus Flavivirus within a phylogenetic framework by principal components analysis. There is a mutual interplay between the evolutionary history of flaviviruses and their respective vectors and/or hosts. Hosts associated to distinct phylogenetic groups may be driving flaviviruses at different pace and through various sequence landscapes, as can be seen for viruses associated with Aedes or Culex spp...
June 16, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28629807/spike-or-not-a-spike-that-is-the-question-in-a-patient-with-single-lead-pacemaker
#14
Antonio Rojas-González, Alberto Cecconi, Jose L Merino, Luis J Jimenez-Borreguero, Fernando Alfonso
Dual-chamber pacing is feasible via the floating atrial sensor electrodes of a single-pass VDD lead but the atrial lead threshold is higher than the accepted clinical standard. Furthermore, due to the floating nature of the system, atrial sensing and pacing thresholds may vary during the follow up. For these reasons this strategy is seldom considered a common pacing solution in routine clinical practice. Alternatively, this phenomenon is likely to be observed as a result of incorrect generator configuration...
June 8, 2017: Journal of Electrocardiology
https://www.readbyqxmd.com/read/28629252/study-of-composite-vascular-scaffold-combining-with-differentiated-vsmc-and-vec-like-cells-in%C3%A2-vitro-and-in%C3%A2-vivo
#15
Xuqian Liu, Jie Wang, Fusheng Dong, Peng Song, Hexiang Li, Yali Hou
Although research into the tissue engineering of vessels has proceeded at a tremendous pace, many deficiencies still need to be resolved. A well-adopted constructed vessel requires both functional and structural properties to stimulate the native vessel and resist stress and tension in vivo. In the present study, we developed a novel three-layer composite vascular scaffold consisting of differentiated vascular smooth muscle cell-, vascular endothelial cell-like cells, and a rabbit acellular vascular matrix (ACVM)-0...
January 1, 2017: Journal of Biomaterials Applications
https://www.readbyqxmd.com/read/28629101/a-mini-review-on-hydrogels-classification-and-recent-developments-in-miscellaneous-applications
#16
REVIEW
Kokkarachedu Varaprasad, Gownolla Malegowd Raghavendra, Tippabattini Jayaramudu, Murali Mohan Yallapu, Rotimi Sadiku
Hydrogels are composed of three-dimensional smart and/or hungry networks, which do not dissolve in water but swell considerably in an aqueous medium, demonstrating an extraordinary ability to absorb water into the reticulated structure. Such inherent feature is a subject of considerable scientific research interest which leads to a dominating path in extending their potential in hi-tech applications. Over the past decades, significant progress has been made in the field of hydrogels. Further, explorations are continuously being made in all directions at an accelerated pace for their extensive usage...
October 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28628349/evaluation-of-a-client-centered-linkage-intervention-for-patients-newly-diagnosed-with-hiv-at-an-urban-united-states-lgbt-center-the-linkage-to-care-specialist-project
#17
Jesse Bendetson, Rhodri Dierst-Davies, Risa Flynn, Matthew R Beymer, Amy R Wohl, K Rivet Amico, Robert K Bolan
Linkage to care (LTC) is a key element of the HIV care continuum, and a crucial bridge from testing and diagnosis to receipt of antiretroviral therapies and viral suppression. In 2012, the Los Angeles LGBT Center hired a full-time LTC specialist (LTC-S), who developed a unique client-centered approach to LTC. This single-arm demonstration project was designed to systematically evaluate the LTC-S intervention. Individuals who were newly diagnosed with HIV between March 2014 and September 2015 were eligible for enrollment...
June 19, 2017: AIDS Patient Care and STDs
https://www.readbyqxmd.com/read/28628011/-criteria-for-selection-of-tumor-cells-and-prospects-for-specific-immunotherapy-for-bladder-cancer
#18
T Slavyanskaya, S -Salnikova, R Sepiashvili
Specific antitumor immunotherapy with autologous dendritic cell vaccines is one of the new approaches of modern medicine. For activation of dendritic cells highly immunogenic antigens are used, however optimal antigens in case of bladder cancer (BC) are still not researched. Cancer-testis antigens (CTA) are the most promising target in the context of creation of antitumor vaccines, because they are distinguished by pronounced immunogenicity, they are detected in different types of tumors and have limited pattern of expression in healthy tissues of grown-up organism...
May 2017: Georgian Medical News
https://www.readbyqxmd.com/read/28627809/ivabradine-reduces-digitalis-induced-ventricular-arrhythmias
#19
Gerrit Frommeyer, Jan Weller, Christian Ellermann, Nils Bögeholz, Patrick Leitz, Dirk G Dechering, Simon Kochhäuser, Kristina Wasmer, Lars Eckardt
The I(f) channel inhibitor ivabradine is recommended for treatment of heart failure but also affects potassium currents and thereby prolongs ventricular repolarization. The aim of the present study was to examine the electrophysiological effects of ivabradine on digitalis-induced ventricular arrhythmias. Thirteen rabbit hearts were isolated and Langendorff-perfused. After obtaining baseline data, the digitalis glycoside ouabain was infused (0.2μM). Monophasic action potentials and ECG showed a significant abbreviation of QT interval (-34ms,p<0...
June 19, 2017: Basic & Clinical Pharmacology & Toxicology
https://www.readbyqxmd.com/read/28627293/new-evidence-of-relative-age-effects-in-super-elite-sportsmen-a-case-for-the-survival-and-evolution-of-the-fittest
#20
Benjamin D Jones, Gavin P Lawrence, Lew Hardy
The relative age effect (RAE) describes an overrepresentation of players born early (Q1) in a selection year and is highly prevalent within youth sport pathways. However, a dearth of research has investigated the RAE at the "super-elite" level. The present research assessed the presence of RAE in super-elite performers. Study 1 investigated RAEs in the world's best international Test cricketers (N = 262) over a 20-year period according to a robust and stringent "super-elite" criteria. Results revealed the RAE (Q1) when all disciplines were combined...
June 19, 2017: Journal of Sports Sciences
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