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https://www.readbyqxmd.com/read/27932218/bisphenol-a-bpa-in-the-serum-of-pet-dogs-following-short-term-consumption-of-canned-dog-food-and-potential-health-consequences-of-exposure-to-bpa
#1
Zoe L Koestel, Robert C Backus, Kaoru Tsuruta, William G Spollen, Sarah A Johnson, Angela B Javurek, Mark R Ellersieck, Charles E Wiedmeyer, Kurunthachalam Kannan, Jingchuan Xue, Nathan J Bivens, Scott A Givan, Cheryl S Rosenfeld
Bisphenol A (BPA) is a widely present endocrine disruptor chemical found in many household items. Moreover, this chemical can bioaccumulate in various terrestrial and aquatic sources; thereby ensuring continual exposure of animals and humans. For most species, including humans, diet is considered the primary route of exposure. However, there has been little investigation whether commercial-brands of dog foods contain BPA and potential health ramifications of BPA-dietary exposure in dogs. We sought to determine BPA content within dog food, whether short-term consumption of these diets increases serum concentrations of BPA, and potential health consequences, as assessed by potential hematological, serum chemistry, cortisol, DNA methylation, and gut microbiome changes, in dogs associated with short-term dietary exposure to BPA...
December 5, 2016: Science of the Total Environment
https://www.readbyqxmd.com/read/27931721/mesoporous-silica-fillers-and-resin-composition-effect-on-dental-composites-cytocompatibility
#2
Nina Attik, Franck Hallay, Laurence Bois, Arnaud Brioude, Brigitte Grosgogeat, Pierre Colon
OBJECTIVE: Many new dental composites containing mesoporous silica fillers have been developed to improve rheological properties and enhance the resin-filler interface. To investigate the correlation between the cytocompatibility of several dental composites and their composition; two aspects have been considered: presence of bisphenol A (BPA)-glycidyl methacrylate (Bis-GMA) or triethyleneglycol-dimethacrylate (TEGDMA) among the resin monomers and presence of porous particles among the filler blends...
December 5, 2016: Dental Materials: Official Publication of the Academy of Dental Materials
https://www.readbyqxmd.com/read/27930651/maternal-and-fetal-pharmacokinetics-of-oral-radiolabeled-and-authentic-bisphenol-a-in-the-rhesus-monkey
#3
Catherine A VandeVoort, Roy R Gerona, Frederick S Vom Saal, Alice F Tarantal, Patricia A Hunt, Anne Hillenweck, Daniel Zalko
The present study was conducted in pregnant rhesus monkeys to determine the rapidity and extent to which BPA reaches the fetal compartment following oral ingestion, and the 24-hr fate of BPA. To assess metabolism changes during the course of pregnancy, we compared BPA biotransformation during the second and third trimesters in the same animals, measuring the levels of sulfated, gluronidated, and free BPA in maternal serum, amniotic fluid, and fetal serum. All animals showed measurable unconjugated and conjugated BPA in the fetal compartment and slow clearance compared to maternal serum...
2016: PloS One
https://www.readbyqxmd.com/read/27926830/what-s-the-key-to-unlocking-the-proteasome-s-gate
#4
Andres H de la Peña, Gabriel C Lander
In this issue of Structure, Bolten et al. (2016) describe the organization of the mycobacterial proteasome in complex with the ATP-independent bacterial proteasome activator (Bpa, PafE). They confirm several activation motifs employed by archaea and eukaryotes and highlight differences that pose Bpa as a novel architectural class of proteasome activators.
December 6, 2016: Structure
https://www.readbyqxmd.com/read/27925325/inflammation-oxidative-stress-and-apoptosis-cascade-implication-in-bisphenol-a-induced-liver-fibrosis-in-male-rats
#5
Sahar El-Sayed Elswefy, Fatma Rizk Abdallah, Hebatallah Husseini Atteia, Alaa Samir Wahba, Rehab Abdallah Hasan
Bisphenol A (BPA) is a key monomer in the production of plastics. It has been shown to be hepatotoxic. Inflammation and oxidative stress are closely linked with liver fibrosis, the major contributing factor to hepatic failure. Therefore, the aim of this study was to evaluate the impact of chronic exposure to BPA on the development of hepatic fibrosis in male rats and to determine the cross-talk between the hepatic cytokine network, oxidative stress and apoptosis. For this purpose, 30 male Wistar albino rats were divided into three equal groups as follows: the first group was given no treatment (normal control group); the second group was given corn oil once daily by oral gavage for 8 weeks (vehicle control group); and the third group received BPA (50 mg/kg body weight/day, p...
December 7, 2016: International Journal of Experimental Pathology
https://www.readbyqxmd.com/read/27923681/evaluation-of-dna-damaging-potential-of-bisphenol-a-and-its-selected-analogs-in-human-peripheral-blood-mononuclear-cells-in-vitro-study
#6
Katarzyna Mokra, Agnieszka Kuźmińska-Surowaniec, Katarzyna Woźniak, Jaromir Michałowicz
In the present study, we have investigated DNA-damaging potential of BPA and its analogs, i.e. bisphenol S (BPS), bisphenol F (BPF) and bisphenol AF (BPAF) in human peripheral blood mononuclear cells (PBMCs) using the alkaline and neutral versions of the comet assay, which allowed to evaluate DNA single strand-breaks (SSBs) and double strandbreaks (DSBs). The use of the alkaline version of comet assay made also possible to analyze the kinetics of DNA repair in PBMCs after exposure of the cells to BPA or its analogs...
December 3, 2016: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/27920131/maternal-urinary-bisphenol-a-concentration-during-midterm-pregnancy-and-children-s-blood-pressure-at-age-4
#7
Sanghyuk Bae, Youn-Hee Lim, Young Ah Lee, Choong Ho Shin, Se-Young Oh, Yun-Chul Hong
Bisphenol A (BPA) has been reported to be associated with adverse health effects, including high blood pressure (BP). BPA is also suspected to cross placenta in pregnancy and might affect children's health. The present study was aimed to evaluate the effect of prenatal exposure to BPA on the BP of the child at the age of 4. We followed up 645 children at the age of 4 who were born from women who participated midterm during their pregnancy in a birth cohort study from August 2008 to July 2011. Because BPA and BP showed nonlinear association, we constructed a piecewise regression model to examine the association between urinary BPA concentration of mother at around 20 weeks of gestation and BP of the child at age 4 and to determine threshold level of BPA for the association...
December 5, 2016: Hypertension
https://www.readbyqxmd.com/read/27918998/simultaneously-determination-of-bisphenol-a-and-its-alternatives-in-sediment-by-ultrasound-assisted-and-solid-phase-extractions-followed-by-derivatization-using-gc-ms
#8
Qiang Wang, Lingyan Zhu, Meng Chen, Xinxin Ma, Xiaolei Wang, Junchao Xia
Bisphenol analogues are a group of chemicals which are being widely applied in industrial and household products owing to regulations on bisphenol A (BPA) in many countries. In this study, an analytical method, including extraction from complex environmental matrices, clean-up using solid phase extraction (SPE) and following-up derivatization prior to gas chromatography coupled with mass spectrometry (GC-MS), was developed to analyze seven commonly used bisphenols in sediment. Five kinds of extraction solvents, four kinds of SPE cartridges, and four kinds of SPE eluting solvents were individually tested for their performances; and the conditions for derivatizing were also optimized...
December 2, 2016: Chemosphere
https://www.readbyqxmd.com/read/27916947/preparation-of-a-bis-gma-free-dental-resin-system-with-synthesized-fluorinated-dimethacrylate-monomers
#9
Shuzhen Luo, Wenbin Zhu, Fang Liu, Jingwei He
With the aim of reducing human exposure to Bisphenol A (BPA) derivatives in dentistry, a fluorinated dimethacrylate monomer was synthesized to replace 2,2-bis[4-(2-hydroxy-3-methacryloy-loxypropyl)-phenyl]propane (Bis-GMA) as the base monomer of dental resin. After mixing with reactive diluent triethyleneglycol dimethacrylate (TEGDMA), fluorinated dimethacrylate (FDMA)/TEGDMA was prepared and compared with Bis-GMA/TEGDMA in physicochemical properties, such as double bond conversion (DC), volumetric shrinkage (VS), water sorption (WS) and solubility (WSL), flexural strength (FS) and modulus (FM)...
December 1, 2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/27916133/the-use-of-a-restricted-access-volatile-supramolecular-solvent-for-the-lc-ms-ms-assay-of-bisphenol-a-in-urine-with-a-significant-reduction-of-phospholipid-based-matrix-effects
#10
José Ángel Salatti-Dorado, Noelia Caballero-Casero, María Dolores Sicilia, María Loreto Lunar, Soledad Rubio
Restricted access-volatile supramolecular solvents (RAM-VOL-SUPRAS) are here proposed as a new strategy for the quick removal of protein and phospholipids and efficient analyte extraction in LC-MS bioanalysis. Quantification of bisphenol A in urine was selected to prove the suitability of this approach for the intended purpose. RAM-VOL-SUPRAS were spontaneously synthesized in urine by addition of hexanol (83 μL) dissolved in THF (150 μL). SUPRAS composition was environment-dependent and an equation for prediction of SUPRAS volume under given experimental conditions was proposed...
January 15, 2017: Analytica Chimica Acta
https://www.readbyqxmd.com/read/27912114/remediation-of-cr-vi-by-inorganic-organic-clay
#11
Suramya I Rathnayake, Wayde N Martens, Yunfei Xi, Ray L Frost, Godwin A Ayoko
Application of inorganic-organic clays (IOCs) for the remediation of hexavalent chromium (Cr (VI)) and the effect of bisphenol-A (BPA) were investigated. IOCs were better adsorbents for the removal of Cr (VI) than organoclay. Solution pH significantly affected the surface charge of IOCs and speciation of Cr in the solution; hence, the adsorption of Cr onto IOCs. Pseudo-second order model and Langmuir model were the best fit for the kinetics and equilibrium data, indicating chemisorption and formation of monolayer on homogenous adsorption sites, respectively...
November 21, 2016: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/27903287/high-content-imaging-quantification-of-multiple-in-vitro-human-neurogenesis-events-after-neurotoxin-exposure
#12
Xian Wu, Anirban Majumder, Robin Webb, Steven L Stice
BACKGROUND: Our objective was to test neural active compounds in a human developmental neurotoxicity (DNT) model that represents neural tube stages of vulnerability. Previously we showed that 14 days in vitro (DIV 14) was sufficient to generate cryopreserved neuronal cells for post thaw neurite recovery assays. However, short exposure and assessment may not detect toxicants that affect an early neurogenesis continuum, from a mitotic human neural progenitor (hNP) cell population through the course of neurite outgrowth in differentiating neurons...
December 1, 2016: BMC Pharmacology & Toxicology
https://www.readbyqxmd.com/read/27898309/diverging-temporal-trends-of-human-exposure-to-bisphenols-and-plastizisers-such-as-phthalates-caused-by-substitution-of-legacy-edcs
#13
Irina Gyllenhammar, Anders Glynn, Bo A G Jönsson, Christian H Lindh, Per Ola Darnerud, Kettil Svensson, Sanna Lignell
Phthalates and phenolic substances were investigated in urine samples from first-time mothers in Uppsala, Sweden, collected between 2009 and 2014. These substances have a comparably fast metabolism and urinary metabolites are predominantly analysed. The main aim was to investigate if measures to decrease production and use of certain phthalates and bisphenol A (BPA) have resulted in decreased human exposure, and to determine if exposures to replacement chemicals have increased. Temporal trends were evaluated for metabolites (n=13) of seven phthalates, a phthalate replacer, four different bisphenols, triclosan, one organophosphate-based flame retardant, and for two pesticides...
November 26, 2016: Environmental Research
https://www.readbyqxmd.com/read/27897085/bisphenol-a-in-soft-drinks-and-canned-foods-and-data-evaluation
#14
Manolis N Tzatzarakis, Vasiliki Karzi, Elena Vakonaki, Marina Goumenou, Matthaios Kavvalakis, Polychronis Stivaktakis, Christina Tsitsimpikou, Ioannis Tsakiris, Apostolos Rizos, Aristidis M Tsatsakis
Bisphenol A is one of the most common industrial chemicals and known to exert endocrine disruption activity. The aim of this study was the quantification of BPA in food stuffs on the Greek market. The applied LC-MS (liquid chromatography mass spectrometry) method was validated for linearity, limit of quantification, accuracy, precision and recovery. 41.7% of the canned solid phase samples, 25.0 % of the canned liquid phase samples and 43.8% of the soft drinks were positive. Mean BPA concentrations (and range) were 33...
November 29, 2016: Food Additives & Contaminants. Part B, Surveillance
https://www.readbyqxmd.com/read/27894913/the-regulation-of-cellular-apoptosis-by-the-ros-triggered-perk-eif2%C3%AE-chop-pathway-plays-a-vital-role-in-bisphenol-a-induced-male-reproductive-toxicity
#15
Li Yin, Yanlin Dai, Zhihong Cui, Xiao Jiang, Wenbin Liu, Fei Han, Ao Lin, Jia Cao, Jinyi Liu
Bisphenol A (2,2-bis(4-hydroxyphenyl)propane, BPA) is ubiquitous in the environment, wildlife, and humans. Evidence from past studies suggests that BPA is associated with decreased semen quality. However, the molecular basis for the adverse effect of BPA on male reproductive toxicity remains unclear. We evaluated the effect of BPA on mouse spermatocytes GC-2 cells and adult mice, and we explored the potential mechanism of its action. The results showed that BPA inhibited cell proliferation and increased the apoptosis rate...
November 25, 2016: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/27889673/conformational-equilibrium-of-phenylacetic-acid-and-its-halogenated-analogues-through-theoretical-studies-nmr-and-ir-spectroscopy
#16
Mariana N Levandowski, Thiago C Rozada, Ulisses Z Melo, Ernani A Basso, Barbara C Fiorin
This paper presents a study on the conformational preferences of phenylacetic acid (PA) and its halogenated analogues (FPA, CPA, BPA). To clarify the effects that rule these molecules' behaviour, theoretical calculations were used, for both the isolated phase and solution, combined with nuclear magnetic resonance (NMR) and infrared (IR) spectroscopy. Most conformations of phenylacetic acid and its halogenated derivatives are stabilized through the hyperconjugative effect, which rules the conformational preference...
November 9, 2016: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/27888310/determination-of-trace-bisphenol-a-in-environmental-water-by-high-performance-liquid-chromatography-using-magnetic-reduced-graphene-oxide-based-solid-phase-extraction-coupled-with-dispersive-liquid-liquid-microextraction
#17
Danping Li, Xiaoguo Ma, Rui Wang, Yumian Yu
Bisphenol A (BPA), an endocrine-disrupting chemical, has received much attention from researchers and the general public. In this paper, a novel method of determining BPA at trace levels was developed, using magnetic reduced graphene oxide (rGO-Fe3O4)-based solid-phase extraction coupled with dispersive liquid-liquid microextraction (DLLME), followed by high-performance liquid chromatographic determination. The rGO-Fe3O4 was prepared and then characterized by Fourier transform infrared spectroscopy, transmission electron microscopy, and vibrating sample magnetometry...
November 25, 2016: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/27888119/prenatal-phthalate-triclosan-and-bisphenol-a-exposures-and-child-visual-spatial-abilities
#18
Joseph M Braun, David C Bellinger, Russ Hauser, Robert O Wright, Aimin Chen, Antonia M Calafat, Kimberly Yolton, Bruce P Lanphear
INTRODUCTION: During fetal development, sex steroids influence sexually dimorphic behaviors, such as visual-spatial abilities. Thus, endocrine disrupting chemicals that impact sex steroids during gestation may affect these behaviors. OBJECTIVE: We investigated the relationship between prenatal urinary phthalate metabolite, triclosan, and BPA concentrations and visual-spatial abilities in a prospective cohort of 198 mother-child dyads. METHODS: Data are from a prospective cohort in Cincinnati, OH (HOME Study)...
November 23, 2016: Neurotoxicology
https://www.readbyqxmd.com/read/27880925/developmental-bisphenol-a-exposure-impairs-sperm-function-and-reproduction-in-zebrafish
#19
Jiangfei Chen, Katerine S Saili, Yueqin Liu, Lelin Li, Yuxin Zhao, Yinhang Jia, Chenglian Bai, Robert L Tanguay, Qiaoxiang Dong, Changjiang Huang
The developmental and reproductive toxicity of bisphenol A (BPA) has been demonstrated in a variety of model systems. Zebrafish (Danio rerio) were waterborne-exposed to BPA during three different developmental stages: embryonic period:6 h post fertilization (hpf) to 5 months post fertilization (mpf); larval period: 6 days post fertilization (dpf) to 5 mpf; and sexually mature period: 3 mpf to 5 mpf. Evaluations included F0 adult growth, reproduction parameters, and F1 offspring development. BPA exposure did not affect zebrafish growth in any of exposure groups...
November 20, 2016: Chemosphere
https://www.readbyqxmd.com/read/27880919/activation-of-g-protein-coupled-receptor-30-by-thiodiphenol-promotes-proliferation-of-estrogen-receptor-%C3%AE-positive-breast-cancer-cells
#20
Bingli Lei, Wei Peng, Gang Xu, Minghong Wu, Yu Wen, Jie Xu, Zhiqiang Yu, Yipei Wang
Many studies have been shown that environmental estrogen bisphenol A (BPA) can activate nuclear receptor (estrogen receptor alpha, ERα) or membrane receptor (G-protein-coupled receptor, GPR30) in breast cancer cells and exerts genomic or nongenomic actions inducing cell proliferation. 4,4'-thiodiphenol (TDP) as one of BPA derivatives exhibits more potent estrogenic activity than BPA does. However, comparatively little is known about the ways in which TDP interferes with these signaling pathways and produces cell biological changes...
November 20, 2016: Chemosphere
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