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https://www.readbyqxmd.com/read/29118754/critical-role-of-plasmacytoid-dendritic-cells-in-regulating-gene-expression-and-innate-immune-responses-to-human-rhinovirus-16
#1
Yang Xi, Niamh M Troy, Denise Anderson, Olga M Pena, Jason P Lynch, Simon Phipps, Anthony Bosco, John W Upham
Though human rhinoviruses (HRVs) are usually innocuous viruses, they can trigger serious consequences in certain individuals, especially in the setting of impaired interferon (IFN) synthesis. Plasmacytoid dendritic cells (pDCs) are key IFN producing cells, though we know little about the role of pDC in HRV-induced immune responses. Herein, we used gene expression microarrays to examine HRV-activated peripheral blood mononuclear cells (PBMCs) from healthy people, in combination with pDC depletion, to assess whether observed gene expression patterns were pDC dependent...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/29107422/synthesis-antitumor-evaluation-and-microarray-study-of-some-new-pyrazolo-3-4-d-1-2-3-triazine-derivatives
#2
Tamer Nasr, Samir Bondock, Mahmoud Youns, Walid Fayad, Wafaa Zaghary
Design and synthesis of new anticancer scaffolds; pyrazolo[3,4-d][1,2,3]triazine derivatives, is a promising solution to overcome drug resistance problem. A series of (E)-2-cyano-N-(aryl)-3-methylthio-3-(substituted-amino)acrylamides 3a-e was synthesized and transformed to the 3-aminopyrazole derivatives 4a-e which were then transformed to the target pyrazolotriazinones 6a-e. All compounds were evaluated for their anticancer activity against three different cancer cell lines namely Huh-7, Panc-1 and CCRF. Compounds 3a, 3c, 6a and 6c showed excellent anticancer activity against Huh-7 cell line (IC50: 4...
December 1, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29031635/correlation-of-altered-expression-of-a-long-non-coding-rna-neat1-in-peripheral-blood-mononuclear-cells-with-dengue-disease-progression
#3
Abhay Deep Pandey, Saptamita Goswami, Shweta Shukla, Shaoli Das, Suman Ghosal, Manisha Pal, Bhaswati Bandyopadhyay, Vishnampettai Ramachandran, Nandita Basu, Vikas Sood, Priyanka Pandey, Jayprokas Chakrabarti, Sudhanshu Vrati, Arup Banerjee
The association of long non-coding RNAs (lncRNAs) with dengue disease progression is currently unknown. Therefore, the present study aimed to identify lncRNAs in different categories of dengue patients and evaluate their association with dengue disease progression. Herein, we examined the expression profiles of lncRNAs and protein-coding genes between other febrile illness (OFI) and different grade of dengue patients through high-throughput RNA sequencing. We identified Nuclear Enriched Abundant Transcript 1 (NEAT1) as one of the differentially expressed lncRNAs (adjusted P ≤ 0...
October 12, 2017: Journal of Infection
https://www.readbyqxmd.com/read/28865488/distinct-transcriptional-and-metabolic-profiles-associated-with-empathy-in-buddhist-priests-a-pilot-study
#4
Junji Ohnishi, Satoshi Ayuzawa, Seiji Nakamura, Shigeko Sakamoto, Miyo Hori, Tomoko Sasaoka, Eriko Takimoto-Ohnishi, Masakazu Tanatsugu, Kazuo Murakami
BACKGROUND: Growing evidence suggests that spiritual/religious involvement may have beneficial effects on both psychological and physical functions. However, the biological basis for this relationship remains unclear. This study explored the role of spiritual/religious involvement across a wide range of biological markers, including transcripts and metabolites, associated with the psychological aspects of empathy in Buddhist priests. METHODS: Ten professional Buddhist priests and 10 age-matched non-priest controls were recruited...
September 2, 2017: Human Genomics
https://www.readbyqxmd.com/read/28619954/a-novel-immune-biomarker-ifi27-discriminates-between-influenza-and-bacteria-in-patients-with-suspected-respiratory-infection
#5
Benjamin M Tang, Maryam Shojaei, Grant P Parnell, Stephen Huang, Marek Nalos, Sally Teoh, Kate O'Connor, Stephen Schibeci, Amy L Phu, Anand Kumar, John Ho, Adrienne F A Meyers, Yoav Keynan, Terry Ball, Amarnath Pisipati, Aseem Kumar, Elizabeth Moore, Damon Eisen, Kevin Lai, Mark Gillett, Robert Geffers, Hao Luo, Fahad Gul, Jens Schreiber, Sandra Riedel, David Booth, Anthony McLean, Klaus Schughart
Host response biomarkers can accurately distinguish between influenza and bacterial infection. However, published biomarkers require the measurement of many genes, thereby making it difficult to implement them in clinical practice. This study aims to identify a single-gene biomarker with a high diagnostic accuracy equivalent to multi-gene biomarkers.In this study, we combined an integrated genomic analysis of 1071 individuals with in vitro experiments using well-established infection models.We identified a single-gene biomarker, IFI27, which had a high prediction accuracy (91%) equivalent to that obtained by multi-gene biomarkers...
June 2017: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/28605413/acute-bovine-viral-diarrhea-virus-infection-inhibits-expression-of-interferon-tau-stimulated-genes-in-bovine-endometrium
#6
Zhangrui Cheng, Latta Chauhan, Amy Teresa Barry, Ayimuguli Abudureyimu, Chike F Oguejiofor, Xing Chen, D Claire Wathes
Bovine viral diarrhea virus (BVDV) can evade host detection by downregulation of interferon signaling pathways. Infection of cows with noncytopathic (ncp) BVDV can cause early embryonic mortality. Upregulation of type I interferon stimulated genes (ISGs) by blastocyst-secreted interferon tau (IFNT) is a crucial component of the maternal recognition of pregnancy (MRP) in ruminants. This study investigated the potential of acute BVDV infection to disrupt MRP by modulating endometrial ISG expression. Endometrial cells from 10 BVDV-free cows were cultured and treated with 0 or 100 ng/ml IFNT for 24 h in the absence or presence of ncpBVDV infection to yield four treatment groups: CONT, ncpBVDV, IFNT, or ncpBVDV+IFNT...
June 1, 2017: Biology of Reproduction
https://www.readbyqxmd.com/read/28558652/salivary-epidermal-growth-factor-correlates-with-hospitalization-length-in-rotavirus-infection
#7
J Gómez-Rial, M J Curras-Tuala, C Talavero-González, C Rodríguez-Tenreiro, L Vilanova-Trillo, A Gómez-Carballa, I Rivero-Calle, A Justicia-Grande, J Pardo-Seco, L Redondo-Collazo, A Salas, F Martinón-Torres
BACKGROUND: The IFI27 interferon gene expression has been found to be largely increased in rotavirus (RV)-infected patients. IFI27 gene encodes for a protein of unknown function, very recently linked to epidermal proliferation and related to the epidermal growth factor (EGF) protein. The EGF is a low-molecular-weight polypeptide that is mainly produced by submandibular and parotid glands, and it plays an important physiological role in the maintenance of oro-esophageal and gastric tissue integrity...
May 30, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28387595/interferon-stimulated-gene-expression-as-a-preferred-biomarker-for-disease-activity-in-aicardi-gouti%C3%A3-res-syndrome
#8
Ben X Wang, Stephanie A Grover, Peter Kannu, Grace Yoon, Ronald M Laxer, E Ann Yeh, Eleanor N Fish
Aicardi-Goutières syndrome (AGS) is an early-onset, genetic disease characterized by recurrent fever, multifocal lesions of the brain, and systemic autoimmunity. We report on 3 AGS patients, 2 siblings with an RNASEH2A gene mutation and 1 patient with a SAMHD1 gene mutation. Serial analysis of peripheral blood from all 3 AGS patients showed consistently elevated expression of the interferon-stimulated genes (ISGs): ISG15, RSAD2, and IFI27, not observed in unaffected family members. Enumeration of circulating white blood cells and platelets and examination of C-reactive protein showed no significant deviation from the normal range for Patient 2 with the RNASEH2A mutation and Patient 3 with the SAMHD1 mutation, even when Patient 2 had magnetic resonance imaging abnormalities and ongoing febrile episodes...
April 2017: Journal of Interferon & Cytokine Research
https://www.readbyqxmd.com/read/28176846/prediction-of-biomarkers-of-oral-squamous-cell-carcinoma-using-microarray-technology
#9
Guang Li, Xian Li, Meng Yang, Lvzi Xu, Shixiong Deng, Longke Ran
Microarray data is used to screen the genes of oral squamous cell carcinoma (OSCC). Microarray data of OSCC and normal tissues were downloaded from GEO database and analyzed with Benjamini-Hochberg (BH) method. Differentially expressed genes (DEGs) were then uploaded on DAVID database to process enrichment analysis. Target genes were finally chosen for verification experiment in vitro and in vivo. 78 DEGs were selected from 54676 genes, including 46 up- and 32 down- regulation. GO term showed that these genes were related to epidermal growth (biological processes), extracellular region (cellular components) and cytokines activity (molecular function)...
February 8, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28108626/a-new-role-for-er%C3%AE-silencing-via-dna-methylation-of-basal-stem-cell-and-emt-genes
#10
Eric A Ariazi, John C Taylor, Michael A Black, Emmanuelle Nicolas, Michael J Slifker, Diana J Azzam, Jeff Boyd
Resistance to hormonal therapies is a major clinical problem in the treatment of estrogen receptor α-positive (ERα(+)) breast cancers. Epigenetic marks, namely DNA methylation of cytosine at specific CpG sites (5mCpG), are frequently associated with ERα(+) status in human breast cancers. Therefore, ERα may regulate gene expression in part via DNA methylation. This hypothesis was evaluated using a panel of breast cancer cell line models of antiestrogen resistance. Microarray gene expression profiling was used to identify genes normally silenced in ERα(+) cells but derepressed upon exposure to the demethylating agent decitabine, derepressed upon long-term loss of ERα expression, and resuppressed by gain of ERα activity/expression...
February 2017: Molecular Cancer Research: MCR
https://www.readbyqxmd.com/read/28038473/gene-expression-changes-in-tumor-free-tongue-tissue-adjacent-to-tongue-squamous-cell-carcinoma
#11
COMPARATIVE STUDY
Linda Boldrup, Xiaolian Gu, Philip J Coates, Lena Norberg-Spaak, Robin Fahraeus, Göran Laurell, Torben Wilms, Karin Nylander
Due to the high frequency of loco-regional recurrences, which could be explained by changes in the field surrounding the tumor, patients with squamous cell carcinoma of head and neck show poor survival. Here we identified a total of 554 genes as dysregulated in clinically tumor free tongue tissue in patients with tongue tumors when compared to healthy control tongue tissue. Among the top dysregulated genes when comparing control and tumor free tissue were those involved in apoptosis (CIDEC, MUC1, ZBTB16, PRNP, ECT2), immune response (IFI27) and differentiation (KRT36)...
March 21, 2017: Oncotarget
https://www.readbyqxmd.com/read/27988795/a-novel-anti-viral-role-for-stat3-in-ifn-%C3%AE-signalling-responses
#12
Rebecca Mahony, Siobhán Gargan, Kim L Roberts, Nollaig Bourke, Sinead E Keating, Andrew G Bowie, Cliona O'Farrelly, Nigel J Stevenson
The cytokine, Interferon (IFN)-α, induces a wide spectrum of anti-viral mediators, via the Janus kinase/signal transducer and activator of transcription (JAK/STAT) pathway. STAT1 and STAT2 are well characterised to upregulate IFN-stimulated gene (ISG) expression; but even though STAT3 is also activated by IFN-α, its role in anti-viral ISG induction is unclear. Several viruses, including Hepatitis C and Mumps, reduce cellular STAT3 protein levels, via the promotion of ubiquitin-mediated proteasomal degradation...
May 2017: Cellular and Molecular Life Sciences: CMLS
https://www.readbyqxmd.com/read/27870860/gene-expression-profile-of-high-ifn-%C3%AE-producers-stimulated-with-leishmania-braziliensis-identifies-genes-associated-with-cutaneous-leishmaniasis
#13
Marcia W Carneiro, Kiyoshi F Fukutani, Bruno B Andrade, Rebecca P Curvelo, Juqueline R Cristal, Augusto M Carvalho, Aldina Barral, Johan Van Weyenbergh, Manoel Barral-Netto, Camila I de Oliveira
BACKGROUND: The initial response to Leishmania parasites is essential in determining disease development or resistance. In vitro, a divergent response to Leishmania, characterized by high or low IFN-γ production has been described as a potential tool to predict both vaccine response and disease susceptibility in vivo. METHODS AND FINDINGS: We identified uninfected and healthy individuals that were shown to be either high- or low IFN-γ producers (HPs and LPs, respectively) following stimulation of peripheral blood cells with Leishmania braziliensis...
November 2016: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/27822537/a-simple-screening-approach-to-prioritize-genes-for-functional-analysis-identifies-a-role-for-interferon-regulatory-factor-7-in-the-control-of-respiratory-syncytial-virus-disease
#14
Jacqueline U McDonald, Myrsini Kaforou, Simon Clare, Christine Hale, Maria Ivanova, Derek Huntley, Marcus Dorner, Victoria J Wright, Michael Levin, Federico Martinon-Torres, Jethro A Herberg, John S Tregoning
Greater understanding of the functions of host gene products in response to infection is required. While many of these genes enable pathogen clearance, some enhance pathogen growth or contribute to disease symptoms. Many studies have profiled transcriptomic and proteomic responses to infection, generating large data sets, but selecting targets for further study is challenging. Here we propose a novel data-mining approach combining multiple heterogeneous data sets to prioritize genes for further study by using respiratory syncytial virus (RSV) infection as a model pathogen with a significant health care impact...
May 2016: MSystems
https://www.readbyqxmd.com/read/27554456/identification-and-validation-of-gene-expression-pattern-and-signature-in-patients-with-immune-thrombocytopenia
#15
Qi-Dong Ye, Hui Jiang, Xue-Lian Liao, Kai Chen, Shan-Shan Li
In the present study, we sought to define genes associated with immune thrombocytopenia (ITP). Microarray analysis revealed that of 1002 genes associated with ITP, 309 genes had downregulated expression and 693 genes had upregulated expression in patients with ITP. Gene set enrichment analysis revealed that 11 pathways were positively correlated to ITP, such as type I diabetes mellitus, intestinal immune network for IgA production, and oxidative phosphorylation. The messenger RNA expression levels of the indicated genes, including HLA-DRB5, IGHV3-66, IFI27, FAM212A, PLD5, tumor necrosis factor (TNF)-α, interferon-γ, interleukin (IL)-1β, and IL-4, were significantly increased in patients with ITP compared with healthy humans, while MMP8, SLC1A3, CRISP3, THBS1, FMN1, and IL-10 were decreased...
February 2017: SLAS Discovery
https://www.readbyqxmd.com/read/27491455/strong-down-regulation-of-glycophorin-genes-a-host-defense-mechanism-against-rotavirus-infection
#16
Antonio Salas, Guillermo Marco-Puche, Juan Carlos Triviño, Alberto Gómez-Carballa, Miriam Cebey-López, Irene Rivero-Calle, Lucía Vilanova-Trillo, Carmen Rodríguez-Tenreiro, José Gómez-Rial, Federico Martinón-Torres
The mechanisms of rotavirus (RV) infection have been analyzed from different angles but the way in which RV modifies the transcriptome of the host is still unknown. Whole transcriptome shotgun sequencing of peripheral blood samples was used to reveal patterns of expression from the genome of RV-infected patients. RV provokes global changes in the transcriptome of infected cells, involving an over-expression of genes involved in cell cycle and chromatin condensation. While interferon IFI27 was hyper-activated, interferon type II was not suggesting that RV has developed mechanisms to evade the innate response by host cells after virus infection...
October 2016: Infection, Genetics and Evolution
https://www.readbyqxmd.com/read/27257790/common-marker-genes-identified-from-various-sample-types-for-systemic-lupus-erythematosus
#17
Peng-Fei Bing, Wei Xia, Lan Wang, Yong-Hong Zhang, Shu-Feng Lei, Fei-Yan Deng
OBJECTIVE: Systemic lupus erythematosus (SLE) is a complex auto-immune disease. Gene expression studies have been conducted to identify SLE-related genes in various types of samples. It is unknown whether there are common marker genes significant for SLE but independent of sample types, which may have potentials for follow-up translational research. The aim of this study is to identify common marker genes across various sample types for SLE. METHODS: Based on four public microarray gene expression datasets for SLE covering three representative types of blood-born samples (monocyte; peripheral blood mononuclear cell, PBMC; whole blood), we utilized three statistics (fold-change, FC; t-test p value; false discovery rate adjusted p value) to scrutinize genes simultaneously regulated with SLE across various sample types...
2016: PloS One
https://www.readbyqxmd.com/read/27193023/elevated-hepatic-lipid-and-interferon-stimulated-gene-expression-in-hcv-gt3-patients-relative-to-non-alcoholic-steatohepatitis
#18
Shikha Shrivastava, Eric G Meissner, Emily Funk, Seerat Poonia, Virender Shokeen, Arun Thakur, Bhawna Poonia, Shiv Kumar Sarin, Nirupma Trehanpati, Shyamasundaran Kottilil
BACKGROUND AND AIMS: HCV GT-3 has a more pronounced effect on hepatic steatosis and host lipids than other HCV genotypes and is proving less responsive to all oral interferon-free treatment with direct acting antiviral agents. As both HCV GT3 infection and NASH can result in steatosis and cirrhosis, we asked whether hepatic transcriptional profiles reflective of the host response to inflammation differed based on the etiology of injury. METHODS: Hepatic gene expression was determined for 48 pre-selected genes known to be associated with hepatic interferon signaling and lipid metabolic pathways in treatment-naïve HCV GT-3 (n = 9) and NASH (n = 14) patients...
November 2016: Hepatology International
https://www.readbyqxmd.com/read/27135915/distinct-expression-of-interferon-induced-protein-with-tetratricopeptide-repeats-ifit-1-2-3-and-other-antiviral-genes-between-subsets-of-dendritic-cells-induced-by-dengue-virus-2-infection
#19
Jingshu Zhang, Daniel Man-Yuen Sze, Benjamin Yat-Ming Yung, Petrus Tang, Wei-June Chen, Kwok-Hung Chan, Polly Hang-Mei Leung
Dengue virus (DENV) infection is an emerging public health hazard threatening inhabitants of the tropics and sub-tropics. Dendritic cells (DCs) are one of the major targets of DENV and the initiators of the innate immune response against the virus. However, current in vitro research on the DENV-DC interaction is hampered by the low availability of ex vivo DCs and donor variation. In the current study, we attempted to develop a novel in vitro DC model using immature DCs derived from the myeloid leukaemia cell line MUTZ-3 (IMDCs) to investigate the DENV-DC interaction...
August 2016: Immunology
https://www.readbyqxmd.com/read/27100186/ifi27-is-a-useful-genetic-marker-for-diagnosis-of-immunoglobulin-a-nephropathy-and-membranous-nephropathy-using-peripheral-blood
#20
Yasuyuki Nagasawa, Daisuke Okuzaki, Eri Muso, Ryohei Yamamoto, Maki Shinzawa, Yukako Iwasaki, Hirotsugu Iwatani, Takeshi Nakanishi, Yoshitaka Isaka, Hiroshi Nojima
Diagnosis of chronic glomerulonephritis (CGN) depends primarily on renal biopsy, which is expensive and requires hospitalization, creating a demand for noninvasive diagnostic method for this disease. We used DNA microarray analysis to search for genes whose expression levels in peripheral blood mononuclear cells (PBMCs) could distinguish between patients with CGN and healthy volunteers (HVs). We selected immunoglobulin A nephropathy (IgAN) and membranous nephropathy (MN) as typical forms of CGN. The mRNA level of the gene encoding interferon (IFN)-alpha-inducible protein 27, IFI27, which is preferentially expressed in podocytes of glomeruli, was lower in PBMCs of IgAN and MN patients than in those of HVs...
2016: PloS One
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