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bdnf AND p75

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https://www.readbyqxmd.com/read/28320273/impact-of-changes-in-neurotrophic-supplementation-on-development-of-alzheimer-s-disease-like-pathology-in-oxys-rats
#1
E A Rudnitskaya, N G Kolosova, N A Stefanova
Alzheimer's disease (AD) is the most common type of age-related dementia. The development of neurodegeneration in AD is closely related to alterations in neurotrophic supplementation of the brain, which may be caused either by disorder of neurotrophin metabolism or by modification of its availability due to changes in the microenvironment of neurons. The underlying mechanisms are not fully understood. In this work, we used senescence-accelerated OXYS rats as a unique model of the sporadic form of AD to examine the relationship of development of AD signs and changes in neurotrophic supplementation of the cortex...
March 2017: Biochemistry. Biokhimii︠a︡
https://www.readbyqxmd.com/read/28230291/therapeutic-potentials-of-bdnf-trkb-in-breast-cancer-current-status-and-perspectives
#2
Amir Tajbakhsh, Amin Mokhtari-Zaer, Mehdi Rezaee, Fahimeh Afzaljavan, Mehdi Rivandi, Seyed Mahdi Hassanian, Gordon A Ferns, Alireza Pasdar, Amir Avan
Brain-derived neurotrophic factor (BDNF) is a potent neurotrophic factor that has been shown to stimulate breast cancer cell growth and metastasis via tyrosine kinase receptors TrkA, TrkB and the p75(NTR) death receptor. The aberrant activation of BDNF/TrkB pathways can modulate several signaling pathways, including Akt/PI3K, Jak/STAT, NF-kB, UPAR/UPA, Wnt/β-catenin and VEGF pathways as well as the ER receptor. Several microRNAs have been identified that are involved in the modulation of BDNF/TrkB pathways...
February 23, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/28215294/bdnf-and-hippocampal-synaptic-plasticity
#3
G Leal, C R Bramham, C B Duarte
Brain-derived neurotrophic factor (BDNF) belongs to a family of small secreted proteins that also include nerve growth factor, neurotrophin 3, and neurotrophin 4. BDNF stands out among all neurotrophins by its high expression levels in the brain and its potent effects at synapses. Several aspects of BDNF biology such as transcription, processing, and secretion are regulated by synaptic activity. Such observations prompted the suggestion that BDNF may regulate activity-dependent forms of synaptic plasticity such as long-term potentiation (LTP), a sustained enhancement of excitatory synaptic efficacy thought to underlie learning and memory...
2017: Vitamins and Hormones
https://www.readbyqxmd.com/read/28150859/brain-derived-neurotrophic-factor-improves-proliferation-of-endometrial-epithelial-cells-by-inhibition-of-endoplasmic-reticulum-stress-during-early-pregnancy
#4
Whasun Lim, Hyocheol Bae, Fuller W Bazer, Gwonhwa Song
Brain-derived neurotrophic factor (BDNF) is a member of the neurotrophin family binds to two transmembrane receptors; neurotrophic receptor tyrosine kinase 2 (NTRK2) with high affinity and p75 with low affinity. Although BDNF-NTRK2 signaling in the central nervous system is known, signaling in the female reproductive system is unknown. Therefore, we determined effects of BDNF on porcine endometrial luminal epithelial (pLE) cells isolated from Day 12 of pregnancy, as well as expression of BDNF and NTRK2 in endometria of cyclic and pregnant pigs...
February 2, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/28119091/functional-interaction-between-bdnf-and-mglur-ii-in-vitro-bdnf-down-regulated-mglur-ii-gene-expression-and-an-mglur-ii-agonist-enhanced-bdnf-induced-bdnf-gene-expression-in-rat-cerebral-cortical-neurons
#5
Shingo Suzuki, Hisatsugu Koshimizu, Naoki Adachi, Hidetada Matsuoka, Satoko Fushimi, Junichiro Ono, Ken-Ichi Ohta, Takanori Miki
Accumulating evidence suggests functional interaction between brain-derived neurotrophic factor (BDNF) and metabotropic glutamate receptor (mGluR) signaling pathways in the central nervous system (CNS). To date, eight subtypes of mGluRs, mGluR1-8, have been identified, and a previous study suggested that BDNF leads to down-regulation of GluR2 mRNA in rat cerebral cortical cultures. However, precise transcriptomic effects of BDNF on other mGluRs and their cellular significance on the BDNF signaling pathway remain largely unknown...
March 2017: Peptides
https://www.readbyqxmd.com/read/28032807/region-specific-expression-of-precursor-and-mature-brain-derived-neurotrophic-factors-after-chronic-alcohol-exposure
#6
Jin-Wei Yang, Wei Ma, Yan-Lei Yang, Xian-Bin Wang, Xing-Tong Li, Tong-Tong Wang, Xiang-Peng Wang, Wei Gao, Jun-Yan Li, Xin-Fu Zhou, Jian-Hui Guo, Li-Yan Li
BACKGROUND: Alcohol abuse is a serious health problem worldwide that causes a variety of physical and mental disorders. Research has shown that the brain-derived neurotrophic factor (BDNF) plays an important role in alcohol addiction. The BDNF precursor (proBDNF) exhibits different actions than BDNF through separate receptors and pathways in the central nervous system. However, the effects of proBDNF and BDNF in alcohol addiction are not fully known. OBJECTIVES: The objective was to identify the expression patterns and effects of proBDNF and BDNF after chronic alcohol exposure...
December 29, 2016: American Journal of Drug and Alcohol Abuse
https://www.readbyqxmd.com/read/27913431/pro-brain-derived-neurotrophic-factor-probdnf-mediated-p75ntr-activation-promotes-depolarizing-actions-of-gaba-and-increases-susceptibility-to-epileptic-seizures
#7
Baptiste Riffault, Nazim Kourdougli, Camille Dumon, Nadine Ferrand, Emmanuelle Buhler, Fabienne Schaller, Caroline Chambon, Claudio Rivera, Jean-Luc Gaiarsa, Christophe Porcher
The brain-derived neurotrophic factor (BDNF) is synthesized as a precursor, namely proBDNF, which can be processed into mature BDNF (mBDNF). Evidences suggest that proBDNF signaling through p75(NTR) may account for the emergence of neurological disorders. These findings support the view that the relative availability of mBDNF and proBDNF forms is an important mechanism underlying brain circuit formation and cognitive functions. Here we describe novel insights into the proBDNF/p75(NTR) mechanisms and function in vivo in modulating neuronal circuit and synaptic plasticity during the first postnatal weeks in rats...
December 1, 2016: Cerebral Cortex
https://www.readbyqxmd.com/read/27878552/strength-and-aerobic-exercises-improve-spatial-memory-in-aging-rats-through-stimulating-distinct-neuroplasticity-mechanisms
#8
Thais Ceresér Vilela, Alexandre Pastoris Muller, Adriani Paganini Damiani, Tamires Pavei Macan, Sabrina da Silva, Paula Bortoluzzi Canteiro, Alisson de Sena Casagrande, Giulia Dos Santos Pedroso, Renata Tiscoski Nesi, Vanessa Moraes de Andrade, Ricardo Aurino de Pinho
Aging is associated with impaired cognition and memory and increased susceptibility to neurodegenerative disorders. Physical exercise is neuroprotective; however, the major evidence of this effect involves studies of only aerobic training in young animals. The benefits of other exercise protocols such as strength training in aged animals remains unknown. Here, we investigated the effect of aerobic and strength training on spatial memory and hippocampal plasticity in aging rats. Aging Wistar rats performed aerobic or strength training for 50 min 3 to 4 days/week for 8 weeks...
November 22, 2016: Molecular Neurobiology
https://www.readbyqxmd.com/read/27830679/-effects-of-ischemia-on-the-expression-of-neurotrophins-and-their-receptors-in-rat-brain-structures-outside-the-lesion-site-including-on-the-opposite-hemisphere
#9
V G Dmitrieva, V V Stavchansky, O V Povarova, V I Skvortsova, S A Limborska, L V Dergunova
Neurotrophins stimulate the regeneration of neural tissue after lesions. It is also known that the sources of neurogenesis and cerebral function recovery are predominantly located in subcortical brain structures. The effects of ischemia on the expression of genes that encode neurotrophins (Bdnf, Ngf, Nt-3) and their receptors (TrkB, TrkA, TrkC, p75) in brain structures outside the lesion site were studied 3, 24, and 72 h after irreversible unilateral occlusion of the middle cerebral artery in rats. Changes in the mRNA expression of these genes were assessed by relative quantification using real-time RT-PCR...
September 2016: Molekuliarnaia Biologiia
https://www.readbyqxmd.com/read/27804259/neuromodulation-by-cerebrovasculature-bdnf-is-it-much-greater-than-we-think
#10
EDITORIAL
C J Ek
No abstract text is available yet for this article.
November 2, 2016: Acta Physiologica
https://www.readbyqxmd.com/read/27683907/the-neurotrophic-factor-receptor-p75-in-the-rat-dorsolateral-striatum-drives-excessive-alcohol-drinking
#11
Emmanuel Darcq, Nadege Morisot, Khanhky Phamluong, Vincent Warnault, Jerome Jeanblanc, Frank M Longo, Stephen M Massa, Dorit Ron
UNLABELLED: Brain-derived neurotrophic factor (BDNF) signaling in the dorsolateral striatum (DLS) keeps alcohol intake in moderation. For example, activation of the BDNF receptor tropomyosin receptor kinase B (TrkB) in the DLS reduces intake in rats that consume moderate amounts of alcohol. Here, we tested whether long-term excessive consumption of alcohol produces neuroadaptations in BDNF signaling in the rat DLS. We found that BDNF was no longer able to gate alcohol self-administration after a history of repeated cycles of binge alcohol drinking and withdrawal...
September 28, 2016: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/27590859/down-regulation-of-brain-derived-neurotrophic-factor-and-its-signaling-components-in-the-brain-tissues-of-scrapie-experimental-animals
#12
Ting-Ting Wang, Chan Tian, Jing Sun, Hui Wang, Bao-Yun Zhang, Cao Chen, Jing Wang, Kang Xiao, Li-Na Chen, Yan Lv, Chen Gao, Qi Shi, Yan Xin, Xiao-Ping Dong
Prion is a unique nucleic acid-free pathogen that causes human and animal fatal neurodegenerative diseases. Brain-derived neurotrophic factor (BDNF) is a prototypic neurotrophin that helps to support the survival of existing neurons, and encourage the growth and differentiation of new neurons and synapses through axonal and dendritic sprouting. There are two distinct classes of glycosylated receptors, neurotrophin receptor p75 (p75NTR) and tropomyosin-related kinase (Trk), that can bind to BDNF. To obtain insights into the possible alterations of brain BDNF and its signaling pathway in prion disease, the levels of BDNF and several molecules in the BDNF pathway in the brain tissues of scrapie agents 263K-infected hamsters were separately evaluated...
October 2016: International Journal of Biochemistry & Cell Biology
https://www.readbyqxmd.com/read/27519317/localization-of-trkb-and-p75-receptors-in-peritoneal-and-deep-infiltrating-endometriosis-an-immunohistochemical-study
#13
Agung Dewanto, Jozsef Dudas, Rudolf Glueckert, Sylvia Mechsner, Anneliese Schrott-Fischer, Ludwig Wildt, Beata Seeber
BACKGROUND: The roles of the neurotrophins NGF (Neurotrophic growth factor) and BDNF (brain-derived neurotrophic factor) in neuronal growth and development are already known. Meanwhile, the neurotrophin receptors TrkA (tropomyosin related kinase A), TrkB, and p75 are important for determining the fate of cells. In endometriosis, this complex system has not been fully elucidated yet. The aim of this study was to evaluate the expression and location of these neurotrophins and their receptors in peritoneal (PE) and deep infiltrating endometriotic (DIE) tissues and to measure and compare the density of nerve fibers in the disease subtypes...
August 12, 2016: Reproductive Biology and Endocrinology: RB&E
https://www.readbyqxmd.com/read/27457814/sorcs2-is-required-for-bdnf-dependent-plasticity-in-the-hippocampus
#14
S Glerup, U Bolcho, S Mølgaard, S Bøggild, C B Vaegter, A H Smith, J L Nieto-Gonzalez, P L Ovesen, L F Pedersen, A N Fjorback, M Kjolby, H Login, M M Holm, O M Andersen, J R Nyengaard, T E Willnow, K Jensen, A Nykjaer
SorCS2 is a member of the Vps10p-domain receptor gene family receptors with critical roles in the control of neuronal viability and function. Several genetic studies have suggested SORCS2 to confer risk of bipolar disorder, schizophrenia and attention deficit-hyperactivity disorder. Here we report that hippocampal N-methyl-d-aspartate receptor-dependent synaptic plasticity is eliminated in SorCS2-deficient mice. This defect was traced to the ability of SorCS2 to form complexes with the neurotrophin receptor p75(NTR), required for pro-brain-derived neurotrophic factor (BDNF) to induce long-term depression, and with the BDNF receptor tyrosine kinase TrkB to elicit long-term potentiation...
December 2016: Molecular Psychiatry
https://www.readbyqxmd.com/read/27425886/brain-derived-neurotrophic-factor-in-mood-disorders-and-antidepressant-treatments
#15
REVIEW
Eero Castrén, Masami Kojima
Levels of brain-derived neurotrophic factor (BDNF) are reduced in the brain and serum of depressed patients and at least the reduction in serum levels is reversible upon successful treatment. These data, together with a wealth of reports using different animal models with depression-like behavior or manipulation of expression of BDNF or its receptor TrkB have implicated BDNF in the pathophysiology of depression as well as in the mechanism of action of antidepressant treatments. Recent findings have shown that posttranslational processing of BDNF gene product can yield different molecular entities that differently influence signaling through BNDF receptor TrkB and the pan-neurotrophin receptor p75(NTR)...
January 2017: Neurobiology of Disease
https://www.readbyqxmd.com/read/27334657/a-small-molecule-trkb-trkc-neurotrophin-receptor-co-activator-with-distinctive-effects-on-neuronal-survival-and-process-outgrowth
#16
Tao Yang, Stephen M Massa, Kevin C Tran, Danielle A Simmons, Jayakumar Rajadas, Anne Y Zeng, Taichang Jang, Sara Carsanaro, Frank M Longo
Neurotrophin (NT) receptors are coupled to numerous signaling networks that play critical roles in neuronal survival and plasticity. Several non-peptide small molecule ligands have recently been reported that bind to and activate specific tropomyosin-receptor kinase (Trk) NT receptors, stimulate their downstream signaling, and cause biologic effects similar to, though not completely overlapping, those of the native NT ligands. Here, in silico screening, coupled with low-throughput neuronal survival screening, identified a compound, LM22B-10, that, unlike prior small molecule Trk ligands, binds to and activates TrkB as well as TrkC...
November 2016: Neuropharmacology
https://www.readbyqxmd.com/read/27312407/probdnf-signaling-regulates-depression-like-behaviors-in-rodents-under-chronic-stress
#17
Yin-Yin Bai, Chun-Sheng Ruan, Chun-Rui Yang, Jia-Yi Li, Zhi-Long Kang, Li Zhou, Dennis Liu, Yue-Qing Zeng, Ting-Hua Wang, Chang-Fu Tian, Hong Liao, Larisa Bobrovskaya, Xin-Fu Zhou
Chronic exposure to stressful environment is a key risk factor contributing to the development of depression. However, the mechanisms involved in this process are still unclear. Brain-derived neurotropic factor (BDNF) has long been investigated for its positive role in regulation of mood, although the role of its precursor, proBDNF, in regulation of mood is not known. In this study, using an unpredictable chronic mild stress (UCMS) paradigm we found that the protein levels of proBDNF were increased in the neocortex and hippocampus of stressed mice and this UCMS-induced upregulation of proBDNF was abolished by chronic administration of fluoxetine...
November 2016: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/27259880/effects-of-cyp-induced-cystitis-on-growth-factors-and-associated-receptor-expression-in-micturition-pathways-in-mice-with-chronic-overexpression-of-ngf-in-urothelium
#18
Beatrice M Girard, Susan Malley, Victor May, Margaret A Vizzard
We have determined if cyclophosphamide (CYP)-induced cystitis produces additional changes in growth factor/receptors expression in the urinary bladder (urothelium, detrusor) and lumbosacral (L6-S1) dorsal root ganglia (DRG) in a transgenic mouse model with chronic urothelial overexpression of NGF (NGF-OE). Functionally, NGF-OE mice treated with CYP exhibit significant increases in voiding frequency above that observed in control NGF-OE mice (no CYP). Quantitative PCR was used to determine NGF, BDNF, VEGF, and receptors (TrkA, TrkB, p75(NTR)) transcripts expression in tissues from NGF-OE and wild-type (WT) mice with CYP-induced cystitis of varying duration (4 h, 48 h, 8 days)...
August 2016: Journal of Molecular Neuroscience: MN
https://www.readbyqxmd.com/read/27251195/peripheral-brain-derived-neurotrophic-factor-precursor-regulates-pain-as-an-inflammatory-mediator
#19
Cong Luo, Xiao-Lin Zhong, Fiona H Zhou, Jia-Yi Li, Pei Zhou, Jun-Mei Xu, Bo Song, Chang-Qi Li, Xin-Fu Zhou, Ru-Ping Dai
The precursor of brain derived neurotrophic factor (proBDNF), the unprocessed BDNF gene product, binds to its receptors and exerts the opposing biologic functions of mature BDNF. proBDNF is expressed in the peripheral tissues but the functions of peripheral proBDNF remain elusive. Here we showed that proBDNF and its predominant receptor, p75 pan-neurotrophin receptor were upregulated in the nerve fibers and inflammatory cells in the local tissue in inflammatory pain. Neutralization of proBDNF by polyclonal antibody attenuated pain in different models of inflammatory pain...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27223597/cellular-and-molecular-mechanisms-regulating-neuronal-growth-by-brain-derived-neurotrophic-factor-bdnf
#20
A Gonzalez, G Moya-Alvarado, C Gonzalez-Billaut, F C Bronfman
Brain-derived neurotrophic factor (BDNF) and its receptors TrkB and p75 regulate dendritic and axonal growth during development and maintenance of the mature nervous system; however, the cellular and molecular mechanisms underlying this process are not fully understood. In recent years, several advances have shed new light on the processes behind the regulation of BDNF-mediated structural plasticity including control of neuronal transcription, local translation of proteins, and regulation of cytoskeleton and membrane dynamics...
May 25, 2016: Cytoskeleton
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