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bdnf AND p75

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https://www.readbyqxmd.com/read/29731813/sevoflurane-induced-memory-impairment-in-the-postnatal-developing-mouse-brain
#1
Zhijun Lu, Jihui Sun, Yichun Xin, Ken Chen, Wen Ding, Yujia Wang
The aim of the present study was to confirm that sevoflurane induces memory impairment in the postnatal developing mouse brain and determine its mechanism of action. C57BL/6 mice 7 days old were randomly assigned into a 2.6% sevoflurane (n=68), a 1.3% sevoflurane (n=68) and a control (n=38) group. Blood gas analysis was performed to evaluate hypoxia and respiratory depression during anesthesia in 78 mice. Measurements for expression of caspase-3 by immunohistochemistry, cleavage of poly adenosine diphosphate-ribose polymerase (PARP) by western blotting, as well as levels of brain-derived neurotrophic factor (BDNF), tyrosine kinase receptor type 2 (Ntrk2), pro-BDNF, p75 neurotrophin receptor (p75NTR) and protein kinase B (PKB/Akt) by enzyme-linked immunosorbent assay were performed in the hippocampus of 12 mice from each group...
May 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29626490/beyond-good-and-evil-a-putative-continuum-sorting-hypothesis-for-the-functional-role-of-probdnf-bdnf-propeptide-mbdnf-in-antidepressant-treatment
#2
REVIEW
Cassiano R A F Diniz, Plinio C Casarotto, Leonardo Resstel, R L Joca Sâmia
Depression and posttraumatic stress disorder are assumed to be maladaptive responses to stress and antidepressants are thought to counteract such responses by increasing BDNF (brain-derived neurotrophic factor) levels. BDNF acts through TrkB (tropomyosin-related receptor kinase B) and plays a central role in neuroplasticity. In contrast, both precursor proBDNF and BDNF propeptide (another metabolic product from proBDNF cleavage) have a high affinity to p75 receptor (p75R) and usually convey apoptosis and neuronal shrinkage...
April 4, 2018: Neuroscience and Biobehavioral Reviews
https://www.readbyqxmd.com/read/29580890/mifepristone-attenuates-depression-like-changes-induced-by-chronic-central-administration-of-interleukin-1%C3%AE-in-rats
#3
Yong-Ping Zhang, Hao-Yin Wang, Cai Zhang, Bai-Ping Liu, Zhi-Lan Peng, Yu-Yu Li, Cai Song
Increased proinflammatory cytokines, such as interleukin (IL)-1β, may play an important role in the etiology of depression because they cause the hypothalamic-pituitary-adrenal axis to release glucocorticoids (GC) and induce dysfunction of serotonin and norepinephrine neurotransmission. Sustained increase in GC may activate microglia to induce neuroinflammation, and suppress astrocytes to produce neurotrophins, which lead to neuronal apoptosis. Here, we tested the hypothesis that glucocorticoid receptor (GR) antagonist mifepristone (RU486) may attenuate IL-1β-induced depression-like behavior by regulating the neuroinflammation and neurotrophin functions of microglia and astrocytes...
March 23, 2018: Behavioural Brain Research
https://www.readbyqxmd.com/read/29490590/effect-of-brain-derived-neurotrophic-factor-on-the-neurogenesis-and-osteogenesis-in-bone-engineering
#4
Qing Liu, Lei Lei, Tao Yu, Ting Jiang, Yunqing Kang
During bone growth, the lack of a neuralized vascular network in the regenerating area can affect subsequent bone quality. This study aimed to investigate if brain-derived neurotrophic factor (BDNF) could promote neurogenesis and osteogenesis in human bone mesenchymal stem cells (hBMSCs) to improve bone formation during tissue engineering. Initially, a safe and effective BDNF concentration that facilitated hBMSC proliferation in vitro was determined. Subsequently, examination of mineralized nodule formation and evaluation of alkaline phosphatase (ALP) activity and ALP gene expression revealed that the most effective concentration of BDNF to elicit a response in hBMSCs was 100 ng/mL...
April 10, 2018: Tissue Engineering. Part A
https://www.readbyqxmd.com/read/29374533/circadian-control-of-p75-neurotrophin-receptor-leads-to-alternate-activation-of-nrf2-and-c-rel-to-reset-energy-metabolism-in-astrocytes-via-brain-derived-neurotrophic-factor
#5
REVIEW
Tetsuro Ishii, Eiji Warabi, Giovanni E Mann
Circadian clock genes regulate energy metabolism partly through neurotrophins in the body. The low affinity neurotrophin receptor p75NTR is a clock component directly regulated by the transcriptional factor Clock:Bmal1 complex. Brain-derived neurotrophic factor (BDNF) is expressed in the brain and plays a key role in coordinating metabolic interactions between neurons and astrocytes. BDNF transduces signals through TrkB and p75NTR receptors. This review highlights a novel molecular mechanism by which BDNF via circadian control of p75NTR leads to daily resetting of glucose and glycogen metabolism in brain astrocytes to accommodate their functional interaction with neurons...
May 1, 2018: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/29330684/investigation-of-mature-bdnf-and-probdnf-signaling-in-a-rat-photothrombotic-ischemic-model
#6
Mehreen Rahman, Haiyun Luo, Neil R Sims, Larisa Bobrovskaya, Xin-Fu Zhou
Treatment with mature brain-derived neurotrophic factor (mBDNF) promotes functional recovery after ischemia in animal trials but the possible role of its precursor protein proBDNF and its receptors or the factors responsible for the conversion of proBDNF to mBDNF in ischemic stroke are not known. The main aim of this study was to characterize the time-dependent expression of genes and/or proteins related to BDNF processing and signaling after ischemia as well as the sensorimotor behavioral dysfunction in a photothrombotic ischemic model in rats...
March 2018: Neurochemical Research
https://www.readbyqxmd.com/read/29129676/exercise-enhances-cognitive-function-and-neurotrophin-expression-in-the-hippocampus-accompanied-by-changes-in-epigenetic-programming-in-senescence-accelerated-mice
#7
Hiroshi Maejima, Naohiko Kanemura, Takanori Kokubun, Kenji Murata, Kiyomi Takayanagi
Aerobic exercise is known to increase expression of neurotrophins, particularly brain-derived neurotrophic factor (BDNF), in the hippocampus and to improve cognitive function. Exercise exerts neuroprotective effects in the hippocampus by inducing epigenetic changes, which play crucial roles in aging and neurodegenerative diseases. Specifically, the activity levels of histone acetyltransferases (HATs) and histone deacetylases (HDACs) regulate histone acetylation and modulate gene transcription. The objective of the present study was to assess the interactive effects of exercise and aging on cognitive function, expression of neurotrophins (BDNF and neurotrophin-4) and their receptors (tyrosine receptor kinase B and p75), and epigenetic regulations, including the activity of HATs and HADCs in the hippocampus...
February 5, 2018: Neuroscience Letters
https://www.readbyqxmd.com/read/29127334/biological-assessments-of-multifunctional-hydrogel-decorated-implantable-neural-cuff-electrode-for-clinical-neurology-application
#8
Han-Jun Kim, Dong Nyoung Heo, Yi Jae Lee, Sang Jin Lee, Ji Yoon Kang, Soo Hyun Lee, I I Keun Kwon, Sun Hee Do
The implantable cuff electrode is an effective neuroprosthetic device in current nerve tissue engineering. However, biocompatibility and stability are still a serious dispute in terms of in vivo function and continuous monitoring. In this regard, assessing the host's biological response to biomaterials is one of the key factors of chronic implantation. In this article, we analyzed the peripheral nerve specific-biological responses to the application of multi-functional hydrogel-coated electrodes. The surface of the cuff electrode was modified using a multifunctional hydrogel composed of PEG hydrogel, cyclosporin A(CsA)-microsphere(MS) and electrodeposited PEDOT:PSS...
November 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29024578/morpho-functional-features-of-the-gonads-of-danio-rerio-the-role-of-brain-derived-neurotrophic-factor
#9
Pietro Cacialli, Livia D'Angelo, Paolo de Girolamo, Luigi Avallone, Carla Lucini, Elisabeth Pellegrini, Luciana Castaldo
Zebrafish, a suitable and widely used teleost fish model in basic biomedical research, displays morphophysiological features of adult gonads that share some commonalities with those of mammalian species. In mammals, gametogenesis is regulated, among several factors, by brain-derived neurotrophic factor (BDNF). This neurotrophin has a well-established role in the developing and adult nervous system, as well as gonads development and functions in vertebrate species. We hypothesize that BDNF has a role also in the gonadal functions of zebrafish...
January 2018: Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology
https://www.readbyqxmd.com/read/28966252/inhibitory-effects-of-polyacetylene-compounds-from-panax-ginseng-on-neurotrophin-receptor-mediated-hair-growth
#10
Aoi Suzuki, Daisuke Matsuura, Hirotoshi Kanatani, Shingo Yano, Mitsuo Tsunakawa, Shigeru Matsuyama, Hideyuki Shigemori
Neurotrophins play an important role in the control of the hair growth cycle. Therefore, neurotrophin receptor antagonists have therapeutic potential for the treatment of hair growth disorders. In this study, we investigated the inhibitory effect of Panax ginseng, a medicinal plant commonly used to treat alopecia, on the binding of neurotrophins to their receptors. In addition, we isolated and characterized the bioactive compounds of P. ginseng extracts. P. ginseng hexane extracts strongly inhibited brain-derived neurotrophic factor (BDNF)-TrkB and β-nerve growth factor (β-NGF)-p75 neurotrophin receptor (p75NTR) binding...
2017: Biological & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/28951257/protective-effects-of-the-neurosteroid-allopregnanolone-in-a-mouse-model-of-spontaneous-motoneuron-degeneration
#11
Maria Meyer, Laura I Garay, María Sol Kruse, Agustina Lara, Gisella Gargiulo-Monachelli, Michael Schumacher, Rachida Guennoun, Hector Coirini, Alejandro F De Nicola, Maria Claudia Gonzalez Deniselle
Amyotrophic lateral sclerosis (ALS) is a devastating disorder characterized by progressive death of motoneurons. The Wobbler (WR) mouse is a preclinical model sharing neuropathological similarities with human ALS. We have shown that progesterone (PROG) prevents the progression of motoneuron degeneration. We now studied if allopregnanolone (ALLO), a reduced metabolite of PROG endowed with gabaergic activity, also prevents WR neuropathology. Sixty-day old WRs remained untreated or received two steroid treatment regimens in order to evaluate the response of several parameters during early or prolonged steroid administration...
November 2017: Journal of Steroid Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/28912711/increased-hippocampal-probdnf-contributes-to-memory-impairments-in-aged-mice
#12
Mona Buhusi, Chris Etheredge, Ann-Charlotte Granholm, Catalin V Buhusi
Memory decline during aging or accompanying neurodegenerative diseases, represents a major health problem. Neurotrophins have long been considered relevant to the mechanisms of aging-associated cognitive decline and neurodegeneration. Mature Brain-Derived Neurotrophic Factor (BDNF) and its precursor (proBDNF) can both be secreted in response to neuronal activity and exert opposing effects on neuronal physiology and plasticity. In this study, biochemical analyses revealed that increased levels of proBDNF are present in the aged mouse hippocampus relative to young and that the level of hippocampal proBDNF inversely correlates with the ability to perform in a spatial memory task, the water radial arm maze (WRAM)...
2017: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/28900083/-the-effects-of-chronic-alcoholization-on-the-expression-of-brain-derived-neurotrophic-factor-and-its-receptors-in-the-brains-of-mice-genetically-predisposed-to-depressive-like-behavior
#13
D V Bazovkina, E M Kondaurova, A S Tsybko, A I Kovetskaya, T V Ilchibaeva, V S Naumenko
Brain-derived neurotropic factor (BDNF) plays an important role in mechanisms of depression. Precursor protein of this factor (proBDNF) can initiate apoptosis in the brain, while the mature form of BDNF is involved in neurogenesis. It is known that chronic alcoholization leads to the activation of apoptotic processes, neurodegeneration, brain injury, and cognitive dysfunction. In this work, we have studied the influence of long-term ethanol exposure on the proBDNF and BDNF protein levels, as well as on the expression of genes that encode these proteins in the brain structures of ASC mice with genetic predisposition to depressive-like behavior and in mice from parental nondepressive CBA strain...
July 2017: Molekuliarnaia Biologiia
https://www.readbyqxmd.com/read/28800076/human-dental-pulp-cells-differentiate-toward-neuronal-cells-and-promote-neuroregeneration-in-adult-organotypic-hippocampal-slices-in-vitro
#14
Li Xiao, Ryoji Ide, Chikako Saiki, Yasuo Kumazawa, Hisashi Okamura
The adult mammalian central nerve system has fundamental difficulties regarding effective neuroregeneration. The aim of this study is to investigate whether human dental pulp cells (DPCs) can promote neuroregeneration by (i) being differentiated toward neuronal cells and/or (ii) stimulating local neurogenesis in the adult hippocampus. Using immunostaining, we demonstrated that adult human dental pulp contains multipotent DPCs, including STRO-1, CD146 and P75-positive stem cells. DPC-formed spheroids were able to differentiate into neuronal, vascular, osteogenic and cartilaginous lineages under osteogenic induction...
August 11, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28761093/combined-serum-levels-of-multiple-proteins-in-tpa-bdnf-pathway-may-aid-the-diagnosis-of-five-mental-disorders
#15
Suzhen Chen, Haitang Jiang, Yang Liu, Zhenhua Hou, Yingying Yue, Yuqun Zhang, Fuying Zhao, Zhi Xu, Yinghui Li, Xiaodong Mou, Lei Li, Tianyu Wang, Jingjing Zhao, Chongyang Han, Yuxiu Sui, Ming Wang, Zhong Yang, Yan Lu, Yifeng Zhu, Jianhua Li, Xinhua Shen, Fei Sun, Qingsong Chen, Huanxin Chen, Yonggui Yuan
Mental disorders are severe, disabling conditions with unknown etiology and are commonly misdiagnosed when clinical symptomology criteria are solely used. Our previous work indicated that combination of serum levels of multiple proteins in tissue plasminogen activator (tPA)-brain-derived neurotrophic factor (BDNF) pathway improved accuracy of diagnosis of major depressive disorder (MDD). Here, we measured serum levels of tPA, plasminogen activator inhibitor-1 (PAI-1), BDNF, precursor-BDNF (proBDNF), tropomyosin-related kinase B (TrkB) and neurotrophin receptor p75 (p75NTR) in patients with paranoid schizophrenia (SZ, n = 34), MDD (n = 30), bipolar mania (BM, n = 30), bipolar depression (BD, n = 22), panic disorder (PD, n = 30), and healthy controls (HCs, n = 30) by Enzyme-linked immunosorbent assay kits...
July 31, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28694020/transdifferentiation-of-brain-derived-neurotrophic-factor-bdnf-secreting-mesenchymal-stem-cells-significantly-enhance-bdnf-secretion-and-schwann-cell-marker-proteins
#16
Metzere Bierlein De la Rosa, Anup D Sharma, Surya K Mallapragada, Donald S Sakaguchi
The use of genetically modified mesenchymal stem cells (MSCs) is a rapidly growing area of research targeting delivery of therapeutic factors for neuro-repair. Cells can be programmed to hypersecrete various growth/trophic factors such as brain-derived neurotrophic factor (BDNF), glial cell line-derived neurotrophic factor (GDNF), and nerve growth factor (NGF) to promote regenerative neurite outgrowth. In addition to genetic modifications, MSCs can be subjected to transdifferentiation protocols to generate neural cell types to physically and biologically support nerve regeneration...
November 2017: Journal of Bioscience and Bioengineering
https://www.readbyqxmd.com/read/28680965/a-brain-derived-neurotrophic-factor-based-p75-ntr-peptide-mimetic-ameliorates-experimental-autoimmune-neuritis-induced-axonal-pathology-and-demyelination
#17
David G Gonsalvez, Giang Tran, Jessica L Fletcher, Richard A Hughes, Suzanne Hodgkinson, Rhiannon J Wood, Sang Won Yoo, Mithraka De Silva, Wong W Agnes, Catriona McLean, Paul Kennedy, Trevor J Kilpatrick, Simon S Murray, Junhua Xiao
Axonal damage and demyelination are major determinants of disability in patients with peripheral demyelinating neuropathies. The neurotrophin family of growth factors are essential for the normal development and myelination of the peripheral nervous system (PNS), and as such are potential therapeutic candidates for ameliorating axonal and myelin damage. In particular, BDNF promotes peripheral nerve myelination via p75 neurotrophin receptor (p75(NTR)) receptors. Here, we investigated the therapeutic efficacy of a small structural mimetic of the region of BDNF that binds to p75(NTR) (cyclo-dPAKKR) in experimental autoimmune neuritis (EAN), an established animal model of peripheral demyelinating neuropathy...
May 2017: ENeuro
https://www.readbyqxmd.com/read/28596120/myelin-induced-inhibition-in-a-spiral-ganglion-organ-culture-approaching-a-natural-environment-in-vitro
#18
Benedikt Kramer, Anke Tropitzsch, Marcus Müller, Hubert Löwenheim
The performance of a cochlear implant depends on the defined interaction between afferent neurons of the spiral ganglion and the inserted electrode. Neurite outgrowth can be induced by neurotrophins such as brain-derived neurotrophic factor (BDNF) via tropomyosin kinase receptor B (TrkB). However, neurotrophin signaling through the p75 neurotrophin receptor (p75) inhibits neurite outgrowth in the presence of myelin. Organotypic cultures derived from postnatal (P3-5) mice were used to study myelin-induced inhibition in the cochlear spiral ganglion...
June 14, 2017: Neuroscience
https://www.readbyqxmd.com/read/28572757/muscle-contraction-regulates-bdnf-trkb-signaling-to-modulate-synaptic-function-through-presynaptic-cpkc%C3%AE-and-cpkc%C3%AE-i
#19
Erica Hurtado, Víctor Cilleros, Laura Nadal, Anna Simó, Teresa Obis, Neus Garcia, Manel M Santafé, Marta Tomàs, Katherine Halievski, Cynthia L Jordan, Maria A Lanuza, Josep Tomàs
The neurotrophin brain-derived neurotrophic factor (BDNF) acts via tropomyosin-related kinase B receptor (TrkB) to regulate synapse maintenance and function in the neuromuscular system. The potentiation of acetylcholine (ACh) release by BDNF requires TrkB phosphorylation and Protein Kinase C (PKC) activation. BDNF is secreted in an activity-dependent manner but it is not known if pre- and/or postsynaptic activities enhance BDNF expression in vivo at the neuromuscular junction (NMJ). Here, we investigated whether nerve and muscle cell activities regulate presynaptic conventional PKC (cPKCα and βI) via BDNF/TrkB signaling to modulate synaptic strength at the NMJ...
2017: Frontiers in Molecular Neuroscience
https://www.readbyqxmd.com/read/28541476/7-8-dihydroxyflavone-ameliorates-cognitive-and-motor-deficits-in-a-huntington-s-disease-mouse-model-through-specific-activation-of-the-plc%C3%AE-1-pathway
#20
Gerardo García-Díaz Barriga, Albert Giralt, Marta Anglada-Huguet, Nuria Gaja-Capdevila, Javier G Orlandi, Jordi Soriano, Josep-Maria Canals, Jordi Alberch
Huntington's disease (HD) is a fatal neurodegenerative disease with motor, cognitive and psychiatric impairment. Dysfunctions in HD models have been related to reduced levels of striatal brain-derived neurotrophic factor (BDNF) and imbalance between its receptors TrkB and p75(NTR). Thus, molecules with activity on the BDNF/TrkB/p75 system can have therapeutic potential. 7,8-Dihydroxyflavone (7,8-DHF) was described as a TrkB agonist in several models of neuro-degenerative diseases, however, its TrkB activation profile needs further investigation due to its pleiotropic properties and divergence from BDNF effect...
August 15, 2017: Human Molecular Genetics
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