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Y-J Yu, W Xiong
OBJECTIVE: To investigate the curative effect of tirofiban combined with recombinant tissue-plasminogen activator (rt-PA) selective intra-arterial thrombolysis on acute middle cerebral artery occlusion (MCAO). MATERIALS AND METHODS: A total of 60 adult male Japanese white rabbits weighing 2.5-3.0 kg were selected, and the acute cerebral infarction model was established via autologous thromboembolism of middle cerebral artery. Rabbits were randomly divided into 4 groups: tirofiban group (Ti group, 5 μg/kg, n=15), rt-PA group (rt-PA group, 2 mg/kg, n=15), tirofiban + rt-PA group (Ti + rt-PA group, 3 μg/kg Ti + 1 mg/kg rt-PA, n=15), and control group (Co group, n=15)...
May 2018: European Review for Medical and Pharmacological Sciences
Che-Sheng Chu, Chin-Liang Chu, Chih-Ching Wu, Ti Lu
BACKGROUND: There is accumulating evidence that neurotrophic factors may be involved in the pathophysiology of patients with schizophrenia. This study aimed to explore the relationship between serum nerve growth factor beta (NGF-beta), brain-derived neurotrophic factor (BDNF), and glial-derived neurotrophic factor (GDNF) levels and psychopathology in unmedicated patients with schizophrenia. METHODS: Serum NGF-beta, BDNF, and GDNF levels were determined using enzyme-linked-immunosorbent assay (ELISA) in the serum of 30 unmedicated patients with schizophrenia...
January 20, 2018: Journal of the Chinese Medical Association: JCMA
I-Hua Wei, Kuang-Ti Chen, Mang-Hung Tsai, Ching-Hsiang Wu, Hsien-Yuan Lane, Chih-Chia Huang
d-Serine is an amino acid and can work as an agonist at the glycine sites of N-methyl-d-aspartate receptor (NMDAR). Interestingly, both types of glutamatergic modulators, NMDAR enhancers and blockers, can improve depression through common targets, namely alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionaic acid receptors (AMPARs) and mammalian target of rapamycin (mTOR). To elucidate the cellular signaling pathway underlying this counterintuitive observation, we activated NMDARs in rats by using d-serine. Saline, ketamine (NMDAR antagonist), and desipramine (tricyclic antidepressant) were used as controls...
December 13, 2017: Journal of Agricultural and Food Chemistry
Michał Panek, Mateusz Jonakowski, Jan Zioło, Tadeusz Pietras, Łukasz Wieteska, Beata Małachowska, Łukasz Mokros, Janusz Szemraj, Piotr Kuna
Asthma is a chronic inflammatory and heterogeneous disease developing mostly through allergic inflammation, which modifies the expression of various cytokines and neurotrophins. Previous studies suggest the involvement of interleukin (IL)-15 in the regulation of immune response in asthma. Brain-derived neurotrophic factor (BDNF) II plays an important role as a regulator of development and survival of neurons as well as maintenance of their physiological activity. Chronic stress associated with asthma and elevated IL-15 mRNA and BDNFII mRNA levels may affect the mood and a subjective sensation of dyspnoea-inducing anxiety...
April 2017: Molecular Neurobiology
Alberto Souza de Sá Filho, Antonio Marcos de Souza Moura, Murilo Khede Lamego, Nuno Barbosa Ferreira Rocha, Flávia Paes, Ana Cristina Oliveira, Eduardo Lattari, Ridson Rimes, João Manochio, Henning Budde, Mirko Wegner, Gioia Mura, Oscar Arias-Carrión, Elie Cheniaux, Ti-Fei Yuan, Antonio Egidio Nardi, Sergio Machado
Cognitive deficits are observed in a variety of domains in patients with bipolar disorder (BD). These deficits are attributed to neurobiological, functional and structural brain factors, particularly in prefrontal cortex. Furthermore, cortical alterations in each phase (mania/hypomania, euthymia and depression) are also present. A growing basis of evidence supports aerobic exercise as an alternative treatment method for BD symptoms. Its benefits for physical health in healthy subjects and some psychiatric disorders are fairly established; however evidence directly addressed to BD is scant...
2015: CNS & Neurological Disorders Drug Targets
Murilo Khede Lamego, Antonio Marcos de Souza Moura, Flávia Paes, Nuno Barbosa Ferreira Rocha, Alberto Souza de Sá Filho, Eduardo Lattari, Ridson Rimes, João Manochio, Henning Budde, Mirko Wegner, Gioia Mura, Oscar Arias-Carrión, Ti-Fei Yuan, Antonio Egidio Nardi, Sergio Machado
The pathophysiology of depression is related to neurobiological changes that occur in the monoamine system, hypothalamic-pituitary-adrenal axis, neurogenesis system and the neuroimmune system. In recent years, there has been a growing interest in the research of the effects of exercise on brain function, with a special focus on its effects on brain-derived neurotrophic factor (BDNF), cortisol and other biomarkers. Thus, the aim of this study is to present a review investigating the acute and chronic effects of aerobic exercise on BDNF and cortisol levels in individuals with depression...
2015: CNS & Neurological Disorders Drug Targets
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