Alberto Souza de Sá Filho, Antonio Marcos de Souza Moura, Murilo Khede Lamego, Nuno Barbosa Ferreira Rocha, Flávia Paes, Ana Cristina Oliveira, Eduardo Lattari, Ridson Rimes, João Manochio, Henning Budde, Mirko Wegner, Gioia Mura, Oscar Arias-Carrión, Elie Cheniaux, Ti-Fei Yuan, Antonio Egidio Nardi, Sergio Machado
Cognitive deficits are observed in a variety of domains in patients with bipolar disorder (BD). These deficits are attributed to neurobiological, functional and structural brain factors, particularly in prefrontal cortex. Furthermore, cortical alterations in each phase (mania/hypomania, euthymia and depression) are also present. A growing basis of evidence supports aerobic exercise as an alternative treatment method for BD symptoms. Its benefits for physical health in healthy subjects and some psychiatric disorders are fairly established; however evidence directly addressed to BD is scant...
2015: CNS & Neurological Disorders Drug Targets