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https://www.readbyqxmd.com/read/29166757/hybrid-imaging-of-musculoskeletal-infections
#1
Andor W Glaudemans, Napoleone Prandini, Marco DI Girolamo, Giuseppe Argento, Chiara Lauri, Elena Lazzeri, Mario Muto, Luca M Sconfienza, Alberto Signore
This review article highlights the role of radiological and nuclear medicine techniques in diagnosis of musculoskeletal infections with particular regard to hybrid imaging of osteomyelitis, prosthetic joint infections, sternal infections and spine infections. Authors conclude on the complementary role of the several techniques with indications for an appropriate diagnostic flow chart, in the light of the recent EANM guidelines on infection.
November 22, 2017: Quarterly Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29166752/immunotherapy-treatment-an-issue-for-metabolic-response
#2
Luca Tagliabue, Antonella Capozza, Claudio Maioli, Andrea Luciani, Anna M Ierardi, Gianpaolo Carrafiello
Since the beginning of second decade of this century, when it was introduced in many oncologic scenarios, immunotherapy has become an important tool in the management of a growing number of cancers. Engaging the host immune system in cancer therapy seems to be useful, improving not only progression free survival but also overall survival, until the achieving the goal that many advanced cancers, previously considered without effective treatment options, have now become successfully treatable. Moreover, considering the relatively recent introduction of these drugs in clinical scenarios and the continuous releasing of new drugs, large validated clinical experiences are lacking and many issues are today debated; by the way, the evaluation of the response to immune-therapy poses major concerns...
November 22, 2017: Quarterly Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29166684/-implantation-of-a-modular-distal-femoral-replacement-with-compressive-osseointegration-as-a-salvage-procedure-in-a-complex-femoral-posttraumatic-setting
#3
Anna Janine Schreiner, Peter Marten de Zwart, Christian Arnscheidt, Ulrich Stöckle, Björn Gunnar Ochs
Background Large bone defects and losses play a crucial role in both tumour surgery and in complex primary and revision total knee replacement. The established options of cemented or uncemented long intramedullary stems are limited by large bone defects and are at risk from relatively high exposure to aseptic loosening. There is no general valid agreement on implant fixation of the distal femur. A further option is the cementless fixation method with compressive osseointegration, based on the so-called Wolff law of bone remodelling...
November 22, 2017: Zeitschrift Für Orthopädie und Unfallchirurgie
https://www.readbyqxmd.com/read/29166245/evidence-supporting-li-rads-major-features-for-ct-and-mr-imaging-based-diagnosis-of-hepatocellular-carcinoma-a-systematic-review
#4
An Tang, Mustafa R Bashir, Michael T Corwin, Irene Cruite, Christoph F Dietrich, Richard K G Do, Eric C Ehman, Kathryn J Fowler, Hero K Hussain, Reena C Jha, Adib R Karam, Adrija Mamidipalli, Robert M Marks, Donald G Mitchell, Tara A Morgan, Michael A Ohliger, Amol Shah, Kim-Nhien Vu, Claude B Sirlin
The Liver Imaging Reporting and Data System (LI-RADS) standardizes the interpretation, reporting, and data collection for imaging examinations in patients at risk for hepatocellular carcinoma (HCC). It assigns category codes reflecting relative probability of HCC to imaging-detected liver observations based on major and ancillary imaging features. LI-RADS also includes imaging features suggesting malignancy other than HCC. Supported and endorsed by the American College of Radiology (ACR), the system has been developed by a committee of radiologists, hepatologists, pathologists, surgeons, lexicon experts, and ACR staff, with input from the American Association for the Study of Liver Diseases and the Organ Procurement Transplantation Network/United Network for Organ Sharing...
November 21, 2017: Radiology
https://www.readbyqxmd.com/read/29166151/biomarkers-and-imaging-of-breast-cancer
#5
Olena Weaver, Jessica W T Leung
OBJECTIVE: The goals of this review are to provide background information on the definitions and applications of the general term "biomarker" and to highlight the specific roles of breast imaging biomarkers in research and clinical breast cancer care. A search was conducted of the main electronic biomedical databases (PubMed, Cochrane, Embase, MEDLINE [Ovid], Scopus, and Web of Science). The search was focused on review literature in general radiology and biomedical sciences and on reviews and primary research articles on biomarkers in breast imaging over the 15 years ending in June 2017...
November 22, 2017: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/29166150/exploring-the-negative-likelihood-ratio-and-how-it-can-be-used-to-minimize-false-positives-in-breast-imaging
#6
Wei T Yang, Jay R Parikh, A Thomas Stavros, Pam Otto, Greg Maislin
OBJECTIVE: This article describes the definition and proposed utilization of negative likelihood ratios (NLRs) as statistical parameters in breast imaging. Examples with calculations are provided using BI-RADS category 4 subcategories. CONCLUSION: By auditing individual performance early and often against American College of Radiology benchmark positive predictive value ranges for the BI-RADS category 4 subcategories, and by fully understanding NLRs and their application in breast imaging, radiologists can minimize false-positive findings and unnecessary biopsies...
November 22, 2017: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/29166149/journal-club-redefining-the-radiology-curriculum-in-medical-school-vertical-integration-and-global-accessibility
#7
Michele Retrouvey, Anthony Paul Trace, Craig W Goodmurphy, Sarah Shaves
OBJECTIVE: Radiology interconnects medical disciplines given that a working understanding of imaging is essential to clinicians of every specialty. Using online education, we created a globally accessible, web-based undergraduate medical radiology curriculum modeled after the National Medical Student Curriculum in Radiology program of the Alliance of Medical Student Educators in Radiology. SUBJECTS AND METHODS: Seventy-four radiology faculty-mentored video modules were produced, 50 of which were integrated into the 1st-year anatomy course...
November 22, 2017: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/29166146/screening-for-lung-cancer-communicating-with-patients
#8
Daniel B Green, Bradley B Pua, Carolyn B Crawford, Genevieve N Abbey, Ian R Drexler, Alan C Legasto, James F Gruden
OBJECTIVE: The purposes of this article are to detail the experience of a single-center academic institution in applying the patient-centered approach to a lung cancer screening program and to examine how this approach can expand to other aspects of follow-up imaging of lung nodules. CONCLUSION: As the practice of patient-centered radiology gains attention, diagnostic radiologists are findings new ways to become more involved in patient care. A lung cancer screening program is one opportunity for radiologists to consult with and educate patients...
November 22, 2017: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/29165823/identification-of-predisposing-factors-for-osteonecrosis-of-the-jaw-after-marginal-mandibulectomy-in-the-surgical-management-of-oral-squamous-cell-carcinoma
#9
Ran Ito, Jung-Ju Huang, Wei-Chuan Hsieh, Huang-Kai Kao, William Wei-Kai Lao, Ku-Hao Fang, Yenlin Huang, Yu-Liang Chang, Ming-Huei Cheng, Kai-Ping Chang
BACKGROUND: The aim of this study is to evaluate osteonecrosis of the jaw (ONJ) with the extent of marginal mandibulectomy. METHODS: Between January 2006 and December 2012, 3087 patients undergoing ablative resection were consecutively enrolled. Among them, 345 cases undergoing marginal mandibulectomy were retrospectively reviewed. RESULTS: The occurrence of ONJ was 5.51% and associated with body mass index, overall stage, diabetes, concomitant mandibulotomy, and radiotherapy (P = 0...
November 22, 2017: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29165809/medical-industry-at-tumor-board-three-years-analysis-of-the-open-payments-database-and-comparison-of-oncologic-specialties
#10
Amanjit S Baadh, Mikin Patel, Ketan Patel, Osman Ahmed
BACKGROUND AND OBJECTIVES: To analyze and contrast medical industry payments across U.S. oncologic providers, including hematology-oncology (HO), surgical oncology (SO), interventional radiology (IR), and radiation oncology (RO). METHODS: Open-payment-data for each provider including provider specialty, state of practice, industry payor, reason for payment, and amount was compiled for each transaction between 2013 and 2015. Total, mean, and median payment amounts per-provider were calculated for each specialty...
November 22, 2017: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29165750/our-experience-in-the-management-of-csf-otorrhea-a-transmastoid-approach-with-middle-ear-cavity-obliteration-and-a-middle-cranial-fossa-approach
#11
Asli Cakir Cetin, Nuri Karabay, Enis Alpin Guneri
In this report, we present two cases of patients with cerebrospinal fluid (CSF) otorrhea who underwent surgical repair through either a transmastoid or middle cranial fossa approach. In our first case, a 34-year-old male after head trauma with conductive hearing loss and a House-Brackmann grade 2 facial palsy was found to have a soft tissue mass protruding through his right tympanic membrane. Radiological examination revealed a wide tegmen tympani defect. He underwent surgery via a transmastoid approach with repair of the defect and blind sac closure of the external auditory canal after middle ear cavity obliteration...
November 1, 2017: Turkish Neurosurgery
https://www.readbyqxmd.com/read/29165745/supratentorial-embryonal-tumors-in-elderly-diagnostic-pitfalls-and-clinical-prognosis
#12
Pierluigi Granaroli, Federica Novegno, Tommaso Lunardi, Pierpaolo Lunardi
Supratentorial embryonal tumours are very rare malignant tumours of neuroectodermal origin, characterized by an aggressive clinical behavior. They occur prevalently in children. They have been sporadically described in adults and represent an even rarer occurrence in elderly patients, raising many issues on the diagnostic pitfalls and their appropriate management. We present an unusual case of embryonal tumor in a 62-year-old man who presented with speech disorder, left IIIrd and Vth cranial nerves partial deficit secondary to a left temporo-insular embryonal tumour: clinico-radiological features, histopathological insights, therapeutic options and results are discussed along with a review of the most relevant literature, addressing the specific issue of differential diagnosis and the expected results in the elderly population...
November 1, 2017: Turkish Neurosurgery
https://www.readbyqxmd.com/read/29165705/preliminary-exploration-of-the-diagnosis-and-treatment-of-skull-based-chondromyxoid-fibromas
#13
Kangmin He, Shize Jiang, Xin Zhang, Ying Mao, Wei Zhu, Yin Wang, Jianping Song, Liang Chen
BACKGROUND: Chondromyxoid fibromas (CMFs) are benign tumors that occur rarely in the skull base. OBJECTIVE: To conduct a preliminary exploration of the diagnosis and treatment of cranial CMFs. METHODS: A retrospective analysis of 19 cases of CMFs in the base of the skull between 2009 and 2014 in our hospital was conducted. The clinical manifestations, imaging characteristics, pathology, treatment strategies, and outcomes were examined. RESULTS: The study cohort included 7 women (36...
November 18, 2017: Operative Neurosurgery (Hagerstown, Md.)
https://www.readbyqxmd.com/read/29165642/the-corticospinal-reserve-capacity-reorganization-of-motor-area-and-excitability-as-a-novel-pathophysiological-concept-in-cervical-myelopathy
#14
Anna Zdunczyk, Vera Schwarzer, Michael Mikhailov, Brendon Bagley, Tizian Rosenstock, Thomas Picht, Peter Vajkoczy
BACKGROUND: In degenerative cervical myelopathy (DCM), the dynamics of disease progression and the outcome after surgical decompression vary interindividually and do not necessarily correlate with radiological findings. OBJECTIVE: To improve diagnostic power in DCM by better characterization of the underlying pathophysiology using navigated transcranial magnetic stimulation (nTMS). METHODS: Eighteen patients with DCM due to cervical spinal canal stenosis were examined preoperatively with nTMS...
November 18, 2017: Neurosurgery
https://www.readbyqxmd.com/read/29165437/endolymphatic-sac-tumour-in-von-hippel-lindau-disease-management-strategies
#15
E Zanoletti, L Girasoli, D Borsetto, G Opocher, A Mazzoni, A Martini
Endolymphatic sac tumour (ELST) is infrequent, as emerges from small series reported in the literature. It is a slow-growing malignancy with local aggressiveness and a low risk of distant metastases. It is often misdiagnosed because of the late onset of symptoms and difficulty in obtaining a biopsy. Its frequency is higher in von Hippel-Lindau (VHL) disease (a genetic systemic syndrome involving multiple tumours), with a prevalence of around 25%. The diagnosis is based on radiology, with specific patterns on contrast-enhanced MRI and typical petrous bone erosion on bone CT scan...
October 2017: Acta Otorhinolaryngologica Italica
https://www.readbyqxmd.com/read/29165288/treatment-related-noncontiguous-radiologic-changes-in-children-with-diffuse-intrinsic-pontine-glioma-treated-with-expanded-irradiation-fields-and-antiangiogenic-therapy
#16
Zoltan Patay, Thomas E Merchant, Rosa Nguyen, Christopher R Pierson, Arzu Onar-Thomas, Alberto Broniscer
PURPOSE: We previously reported the cases of 3 children with diffuse intrinsic pontine glioma (DIPG) in whom noncontiguous treatment-related abnormalities (NCTRAs) developed in the brain after expanded-field radiation therapy (RT). To investigate the occurrence and putative mechanism of NCTRAs, we reviewed brain magnetic resonance imaging studies of patients with DIPG treated in 2 consecutive phase I clinical trials (trials 1 and 2). METHODS AND MATERIALS: The 55 children included in these trials received small-molecule inhibitors: vandetanib in trial 1 (n=32; mean age 6...
December 1, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/29164837/serum-surfactant-protein-d-and-exhaled-nitric-oxide-as-biomarkers-of-early-lung-damage-in-systemic-sclerosis
#17
Alida Benfante, Riccardo Messina, Alessandra Paternò, Nicola Scichilone
BACKGROUND: Interstitial lung disease (ILD) complicates the course of systemic sclerosis (SSc), representing the main cause of death in these patients. The identification of parameters that can predict the early onset and progression of ILD in SSc represents an unmet need in clinical practice. The study was designed to explore whether the surfactant proteins (SP) A and D may be used as noninvasive tools for the early identification of ILD in SSc. Alveolar exhaled nitric oxide (NO) was investigated as a surrogate marker of distal inflammation...
November 21, 2017: Minerva Medica
https://www.readbyqxmd.com/read/29164561/study-of-prevalence-and-influencing-factors-of-depression-in-tumor-patients-and-the-therapeutic-effects-of-fluoxetine
#18
J Dai, N Liao, J Shi, J-Q Tao
OBJECTIVE: To observe the depression in patients with malignant tumor and influencing factors of the disease, as well as to investigate the effects of fluoxetine on depressive symptoms in cancer patients and the immune function. PATIENTS AND METHODS: 262 patients with malignant tumors, confirmed by pathological and radiological diagnosis as malignant tumor were randomly divided into 2 groups: the control group with chemotherapy; the treatment group with chemotherapy and 20 mg/d fluoxetine for six weeks...
November 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29164531/biphasic-bioresorbable-scaffold-trufit-%C3%A2-in-knee-osteochondral-defects-3-t-mri-evaluation-of-osteointegration-in-patients-with-a-5-year-minimum-follow-up
#19
G Bugelli, F Ascione, G Dell'Osso, V Zampa, S Giannotti
PURPOSE: The aim of this study is to follow morphological imaging characteristics and osteointegration of TruFit(®) bone graft substitute (BGS) plugs in cases of chondral and osteochondral defects of the articular surface of the knee joint, using high-quality cartilage-sensitive 3-T magnetic resonance imaging (MRI), linked to clinical outcomes. METHODS: The MRI was used to assess osteointegration and biological evolution of the TruFit(®) BGS plugs in cases with minimum 5-year follow-up: The TruFit(®) plug was used in 46 patients for a total of 47 cases with mean age of 57...
November 21, 2017: Musculoskeletal Surgery
https://www.readbyqxmd.com/read/29164508/eus-guided-transrectal-evacuation-of-organized-pelvic-collection-following-roux-en-y-gastric-bypass-after-failure-of-radiological-and-surgical-approach
#20
Gianfranco Donatelli, Jean-Loup Dumont, Fabrizio Cereatti, Bruto Randone, Bruno Meduri, Panagiotis Lainas, Hadrien Tranchart, Ibrahim Dagher
INTRODUCTION: Postoperative collections are an important cause of morbidity following obesity surgery. Surgical revision is most often required if general sepsis is present. Conservative treatment consists of broad spectrum antibiotics and percutaneous drainage of any collection. EUS drainage is a new technique that is gaining momentum allowing an easy access to collections close to the GI tract. MATERIALS AND METHODS: We present the case report of a 39-year-old woman who underwent to robotic Roux-en-Y gastric bypass for morbid obesity...
November 21, 2017: Obesity Surgery
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