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https://www.readbyqxmd.com/read/29928760/mild-electrical-stimulation-with-heat-shock-reduces-the-inflammatory-symptoms-in-imiquimod-induced-psoriasis-mouse-model
#1
Yu Tsurekawa, Misaki Morita, Mary Ann Suico, Masataka Moriuchi, Yoshio Nakano, Mariam Piruzyan, Masafumi Takada, Sanako Fukami, Tsuyoshi Shuto, Hirofumi Kai
Psoriasis is a chronic skin disease caused by immune disorder. The chronic skin inflammation involves inflammatory molecules that are released from T lymphocytes and keratinocytes. Therefore, developing an anti-inflammatory therapy that is suitable for long-term treatment is needed. Electrical stimulation induces biological responses by modulating intracellular signaling pathways. Our previous studies showed that the optimized combination treatment of mild electrical stimulation (MES, 0.1-millisecond; ms, 55-pulses per second; pps) and heat shock (HS, 42°C) modulates inflammatory symptoms of metabolic disorders and chronic kidney disease in mice models and clinical trials...
June 21, 2018: Experimental Dermatology
https://www.readbyqxmd.com/read/29928647/loss-of-metabolic-flexibility-in-the-failing-heart
#2
REVIEW
Qutuba G Karwi, Golam M Uddin, Kim L Ho, Gary D Lopaschuk
To maintain its high energy demand the heart is equipped with a highly complex and efficient enzymatic machinery that orchestrates ATP production using multiple energy substrates, namely fatty acids, carbohydrates (glucose and lactate), ketones and amino acids. The contribution of these individual substrates to ATP production can dramatically change, depending on such variables as substrate availability, hormonal status and energy demand. This "metabolic flexibility" is a remarkable virtue of the heart, which allows utilization of different energy substrates at different rates to maintain contractile function...
2018: Frontiers in Cardiovascular Medicine
https://www.readbyqxmd.com/read/29928466/genome-wide-analysis-reveals-the-extrinsic-cellulolytic-and-biohydrogen-generating-abilities-of-neocallimastigomycota-fungi
#3
Ayyappa Kumar Sista Kameshwar, Wensheng Qin
Ruminating animals, especially cattle lack the carbohydrate active enzyme encoding genes which are required for the degradation of the glycosidic linkages of plant cell wall carbohydrates (such as cellulose, hemicellulose, lignin and pectin). Thus, ruminating animals are completely dependent on the microorganisms (anaerobic bacteria and fungi, methanogenic archaea and protozoa) residing in their rumen (hindgut). In this study, we have retrieved and analyzed the complete genome wide annotations of the Neocallimastigomycota division fungi such as Anaeromyces robustus, Neocallismatix californiae, Orpinomyces sp, Piromyces finnis, Piromyces sp E2...
2018: Journal of Genomics
https://www.readbyqxmd.com/read/29928337/dysregulated-genes-targeted-by-micrornas-and-metabolic-pathways-in-bladder-cancer-revealed-by-bioinformatics-methods
#4
Lu Zhang, Cuihua Feng, Yamin Zhou, Qiong Zhou
The present study aimed to identify bladder cancer-associated microRNAs (miRNAs) and target genes, and further analyze the potential molecular mechanisms involved in bladder cancer. The mRNA and miRNA expression profiling dataset GSE40355 was downloaded from the Gene Expression Omnibus database. The Limma package in R was used to identify differential expression levels. The Human microRNA Disease Database was used to identify bladder cancer-associated miRNAs and Target prediction programs were used to screen for miRNA target genes...
June 2018: Oncology Letters
https://www.readbyqxmd.com/read/29927623/modulating-glucose-metabolism-and-lactate-synthesis-in-injured-mouse-tendons-treatment-with-dichloroacetate-a-lactate-synthesis-inhibitor-improves-tendon-healing
#5
Kairui Zhang, Michael W Hast, Soutarou Izumi, Yu Usami, Snehal Shetye, Ngozi Akabudike, Nancy J Philp, Masahiro Iwamoto, Itzhak Nissim, Louis J Soslowsky, Motomi Enomoto-Iwamoto
BACKGROUND: Tendon injuries are common problems among athletes. Complete recovery of the mechanical structure and function of ruptured tendons is challenging. It has been demonstrated that upregulation of glycolysis and lactate production occurs in wounds, inflammation sites, and cancerous tumors, and these metabolic changes also control growth and differentiation of stem and progenitor cells. Similar metabolic changes have been reported in human healing tendons. In addition, lactate production has increased in progenitors isolated from injured tendons after treatment with IL-1β...
June 1, 2018: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/29926968/effect-of-tildrakizumab-mk-3222-a-high-affinity-selective-anti-il23p19-monoclonal-antibody-on-cytochrome-p450-metabolism-in-subjects-with-moderate-to-severe-psoriasis
#6
S Khalilieh, A Hussain, D Montgomery, V Levine, P M Shaw, I Bodrug, L Mekokishvili, C Bailey-Smith, X S Glasgow, A Cheng, M Martinho, M Iwamoto
AIMS: Tildrakizumab, an interleukin (IL)-23 inhibitor, is indicated for the treatment of moderate to severe chronic plaque psoriasis. Although tildrakizumab is not metabolized by, and does not alter, cytochrome P450 (CYP) expression in vitro, clinically-significant pharmacokinetic effects through changes in systemic inflammation, which alters CYP metabolism, have been well documented. At the time of study conduct, the effect of modulation of inflammation/cytokines, including IL-23 inhibition with tildrakizumab, on CYP metabolism, and therefore the potential for disease-drug interactions, in psoriasis patients was unknown...
June 21, 2018: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/29926420/pharmacological-modulation-of-glycosphingolipid-metabolism
#7
Jin-Ichi Inokuchi, Takashi Ode, Miki Hara-Yokoyama
The experimental approach to deplete cellular glycosphingolipids (GSLs) with the specific inhibitors of glycosphingolipid biosynthesis has the potential to identify functions of endogenous GSLs. Most GSLs are derived from glucosylceramide (GlcCer). D-threo-1-phenyl-2-decanoylamino-3-morpholino-1-propanol (D-PDMP) inhibits GIcCer synthase and has been used extensively to study the biological functions of living cells. D-PDMP inhibits mTORC1 activity, which is independent of its inhibitory activity on GlcCer synthase...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29926355/identification-of-proteins-differentially-expressed-by-quercetin-treatment-in-a-middle-cerebral-artery-occlusion-model-a-proteomics-approach
#8
Fawad-Ali Shah, Dong-Ju Park, Phil-Ok Koh
Cerebral ischemia is a major cause of death and neurological disability. It also leads to severe brain tissue damage by excessive generation of oxidative stress. Quercetin is a bioflavonoid substance that acts an antioxidant agent and exerts a neuroprotective effect against cerebral ischemia. The aim of this study was to detect specific proteins that are differentially expressed in response to quercetin treatment in focal cerebral ischemia. Adult male rats were intraperitoneally injected with vehicle or quercetin (10 mg/kg) 30 min prior to right middle cerebral artery occlusion (MCAO)...
June 20, 2018: Neurochemical Research
https://www.readbyqxmd.com/read/29925944/a-stromal-cell-population-that-inhibits-adipogenesis-in-mammalian-fat-depots
#9
Petra C Schwalie, Hua Dong, Magda Zachara, Julie Russeil, Daniel Alpern, Nassila Akchiche, Christian Caprara, Wenfei Sun, Kai-Uwe Schlaudraff, Gianni Soldati, Christian Wolfrum, Bart Deplancke
Adipocyte development and differentiation have an important role in the aetiology of obesity and its co-morbidities1,2 . Although multiple studies have investigated the adipogenic stem and precursor cells that give rise to mature adipocytes3-14 , our understanding of their in vivo origin and properties is incomplete2,15,16 . This is partially due to the highly heterogeneous and unstructured nature of adipose tissue depots 17 , which has proven difficult to molecularly dissect using classical approaches such as fluorescence-activated cell sorting and Cre-lox lines based on candidate marker genes16,18 ...
June 20, 2018: Nature
https://www.readbyqxmd.com/read/29925918/aspirin-inhibits-the-proliferation-of-hepatoma-cells-through-controlling-glut1-mediated-glucose-metabolism
#10
Yun-Xia Liu, Jin-Yan Feng, Ming-Ming Sun, Bo-Wen Liu, Guang Yang, Ya-Nan Bu, Man Zhao, Tian-Jiao Wang, Wei-Ying Zhang, Hong-Feng Yuan, Xiao-Dong Zhang
Aspirin can efficiently inhibit liver cancer growth, but the mechanism is poorly understood. In this study, we report that aspirin modulates glucose uptake through downregulating glucose transporter 1 (GLUT1), leading to the inhibition of hepatoma cell proliferation. Our data showed that aspirin significantly decreased the levels of reactive oxygen species (ROS) and glucose consumption in hepatoma cells. Interestingly, we identified that GLUT1 and HIF1α could be decreased by aspirin. Mechanically, we demonstrated that the -1008/-780 region was the regulatory element of transcriptional factor NF-κB in GLUT1 promoter by luciferase report gene assays...
June 20, 2018: Acta Pharmacologica Sinica
https://www.readbyqxmd.com/read/29925774/dietary-supplementation-with-a-magnesium-rich-marine-mineral-blend-enhances-the-diversity-of-gastrointestinal-microbiota
#11
Erin K Crowley, Caitriona M Long-Smith, Amy Murphy, Elaine Patterson, Kiera Murphy, Denise M O'Gorman, Catherine Stanton, Yvonne M Nolan
Accumulating evidence demonstrates that dietary supplementation with functional food ingredients play a role in systemic and brain health as well as in healthy ageing. Conversely, deficiencies in calcium and magnesium as a result of the increasing prevalence of a high fat/high sugar "Western diet" have been associated with health problems such as obesity, inflammatory bowel diseases, and cardiovascular diseases, as well as metabolic, immune, and psychiatric disorders. It is now recognized that modulating the diversity of gut microbiota, the population of intestinal bacteria, through dietary intervention can significantly impact upon gut health as well as systemic and brain health...
June 20, 2018: Marine Drugs
https://www.readbyqxmd.com/read/29925765/anti-inflammatory-effects-of-resveratrol-mechanistic-insights
#12
REVIEW
Diego de Sá Coutinho, Maria Talita Pacheco, Rudimar Luiz Frozza, Andressa Bernardi
Inflammation is the principal response invoked by the body to address injuries. Despite inflammation constituting a crucial component of tissue repair, it is well known that unchecked or chronic inflammation becomes deleterious, leading to progressive tissue damage. Studies over the past years focused on foods rich in polyphenols with anti-inflammatory and immunomodulatory properties, since inflammation was recognized to play a central role in several diseases. In this review, we discuss the beneficial effects of resveratrol, the most widely investigated polyphenol, on cancer and neurodegenerative, respiratory, metabolic, and cardiovascular diseases...
June 20, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29925665/apobec3g-regulated-host-factors-interfere-with-measles-virus-replication-role-of-redd1-and-mtorc1-inhibition
#13
Vishakha Tiwarekar, Julia Wohlfahrt, Markus Fehrholz, Claus-Jürgen Scholz, Susanne Kneitz, Jürgen Schneider-Schaulies
We found earlier that ectopic expression of the cytidine deaminase APOBEC3G (A3G) in Vero cells inhibits measles (MV), respiratory syncytial and mumps virus, while the mechanism of inhibition remained unclear. A microarray analysis revealed that in A3G transduced Vero cells several cellular transcripts were differentially expressed suggesting that A3G regulates the expression of host factors. One of the best up-regulated host cell factors, REDD1 (regulated in development and DNA damage response-1, also called DDIT4), reduced MV replication ∼10 fold upon over-expression in Vero cells...
June 20, 2018: Journal of Virology
https://www.readbyqxmd.com/read/29925637/interrogation-of-nonconserved-human-adipose-lincrnas-identifies-a-regulatory-role-of-linc-adal-in-adipocyte-metabolism
#14
Xuan Zhang, Chenyi Xue, Jennie Lin, Jane F Ferguson, Amber Weiner, Wen Liu, Yumiao Han, Christine Hinkle, Wenjun Li, Hongfeng Jiang, Sager Gosai, Melanie Hachet, Benjamin A Garcia, Brian D Gregory, Raymond E Soccio, John B Hogenesch, Patrick Seale, Mingyao Li, Muredach P Reilly
Long intergenic noncoding RNAs (lincRNAs) have emerged as important modulators of cellular functions. Most lincRNAs are not conserved among mammals, raising the fundamental question of whether nonconserved adipose-expressed lincRNAs are functional. To address this, we performed deep RNA sequencing of gluteal subcutaneous adipose tissue from 25 healthy humans. We identified 1001 putative lincRNAs expressed in all samples through de novo reconstruction of noncoding transcriptomes and integration with existing lincRNA annotations...
June 20, 2018: Science Translational Medicine
https://www.readbyqxmd.com/read/29925517/feeding-state-regulates-pheromone-mediated-avoidance-behavior-via-the-insulin-signaling-pathway-in-caenorhabditis-elegans
#15
Leesun Ryu, YongJin Cheon, Yang Hoon Huh, Seondong Pyo, Satya Chinta, Hongsoo Choi, Rebecca A Butcher, Kyuhyung Kim
Animals change sensory responses and their eventual behaviors, depending on their internal metabolic status and external food availability. However, the mechanisms underlying feeding state-dependent behavioral changes remain undefined. Previous studies have shown that Caenorhabditis elegans hermaphrodite exhibits avoidance behaviors to acute exposure of a pheromone, ascr#3 (asc-ΔC9, C9). Here, we show that the ascr#3 avoidance behavior is modulated by feeding state via the insulin signaling pathway. Starvation increases ascr#3 avoidance behavior, and loss-of-function mutations in daf-2 insulin-like receptor gene dampen this starvation-induced ascr#3 avoidance behavior...
June 19, 2018: EMBO Journal
https://www.readbyqxmd.com/read/29925320/root-proteomic-and-metabolic-analyses-reveal-specific-responses-to-drought-stress-in-differently-tolerant-grapevine-rootstocks
#16
Bhakti Prinsi, Alfredo Simone Negri, Osvaldo Failla, Attilio Scienza, Luca Espen
BACKGROUND: Roots play a central role in plant response to water stress (WS). They are involved in its perception and signalling to the leaf as well as in allowing the plant to adapt to maintaining an adequate water balance. Only a few studies have investigated the molecular/biochemical responses to WS in roots of perennial plants, such as grapevine. This study compares two grapevine rootstock genotypes (i.e. 101.14 and M4) with different tolerance to WS, evaluating the responses at proteomic and metabolite levels...
June 20, 2018: BMC Plant Biology
https://www.readbyqxmd.com/read/29925319/integration-of-proteomic-and-transcriptomic-profiles-reveals-multiple-levels-of-genetic-regulation-of-salt-tolerance-in-cotton
#17
Zhen Peng, Shoupu He, Wenfang Gong, Feifei Xu, Zhaoe Pan, Yinhua Jia, Xiaoli Geng, Xiongming Du
BACKGROUND: Salinity is a major abiotic stress that limits upland cotton growth and reduces fibre production worldwide. To reveal genetic regulation via transcript and protein levels after salt stress, we comprehensively analysed the global changes in mRNA, miRNA, and protein profiles in response to salt stress in two contrasting salt-tolerant cotton genotypes. RESULTS: In the current study, proteomic and mRNA-seq data were combined to reveal that some genes are differentially expressed at both the proteomic and mRNA levels...
June 20, 2018: BMC Plant Biology
https://www.readbyqxmd.com/read/29925069/vasopressin-and-diabetic-kidney-disease
#18
Ray El Boustany
BACKGROUND: Diabetic nephropathy has become the most common cause of chronic kidney disease (CKD). Despite the progress accomplished in therapy, the prevalence of renal disorders remains high. Some modifiable factors driving the increase in incidence of CKD, in diabetes and other settings, might have been overlooked. Consistent evidence supports a role for vasopressin, hydration state, and urine concentration in kidney health. SUMMARY: Plasma vasopressin is elevated in diabetes, even if metabolic control is good...
2018: Annals of Nutrition & Metabolism
https://www.readbyqxmd.com/read/29925002/an-hsp20-fbxo4-axis-regulates-adipocyte-function-through-modulating-ppar%C3%AE-ubiquitination
#19
Jiangtong Peng, Yutian Li, Xiaohong Wang, Shan Deng, Jenna Holland, Emily Yates, Jing Chen, Haitao Gu, Kobina Essandoh, Xingjiang Mu, Boyu Wang, Robert K McNamara, Tianqing Peng, Anil G Jegga, Tiemin Liu, Takahisa Nakamura, Kai Huang, Diego Perez-Tilve, Guo-Chang Fan
Exposure to cold temperature is well known to upregulate heat shock protein (Hsp) expression and recruit and/or activate brown adipose tissue and beige adipocytes in humans and animals. However, whether and how Hsps regulate adipocyte function for energy homeostatic responses is poorly understood. Here, we demonstrate a critical role of Hsp20 as a negative regulator of adipocyte function. Deletion of Hsp20 enhances non-shivering thermogenesis and suppresses inflammatory responses, leading to improvement of glucose and lipid metabolism under both chow diet and high-fat diet conditions...
June 19, 2018: Cell Reports
https://www.readbyqxmd.com/read/29924727/the-role-of-acid-sphingomyelinase-and-modulation-of-sphingolipid-metabolism-in-bacterial-infection
#20
Alexander Simonis, Alexandra Schubert-Unkmeir
Acid sphingomyelinase (ASM) is a key enzyme in sphingolipid metabolism that converts sphingomyelin to ceramide, thereby modulating membrane structures and signal transduction. Bacterial pathogens can manipulate ASM activity and function, and use host sphingolipids during multiple steps of their infection process. An increase in ceramides upon infection results in the formation of ceramide-enriched membrane platforms that serve to cluster receptor molecules and organize intracellular signaling molecules, thus facilitating bacterial uptake...
June 1, 2018: Biological Chemistry
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