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https://www.readbyqxmd.com/read/28107758/retroperitoneal-unicentric-castleman-s-disease-a-case-report
#1
Nihed Abdessayed, Ahlem Bdioui, Houssem Ammar, Rahul Gupta, Nozha Mhamdi, Marwa Guerfela, Moncef Mokni
INTRODUCTION: Castleman's disease (CD) is an angio-follicular lymph node hyperplasia presenting as a localized or a systemic disease masquerading malignancy. The most common sites of CD are mediastinum, neck, axilla and pelvis. Unicentric CD in the peripancreatic region is very rare. PRESENTATION OF CASE: We report a case of the 34-year-old lady presenting with epigastric pain for 3 months. Abdominal imaging revealed a retroperitoneal mass arising from the pancreas suspected to be neuroendocrine tumor...
January 5, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/28100861/-a-case-of-intracranial-localized-castleman-s-disease-mimicking-convexity-meningioma
#2
Keisuke Ozono, Takashi Fujimoto, Makoto Hirose, Ichiro Kawahara, Kazuyoshi Uchihashi
A 68-year-old man presented with abnormal behavior and Todd's paralysis on the right side after having taken a bath. Computed tomography and magnetic resonance imaging revealed a tumor mimicking convexity meningioma that had a perifocal edema, although its mass was not very large. The patient underwent surgery, and full recovery was achieved following a total removal of the lesion. Pathohistological examination demonstrated an intermediate type of Castleman's disease. The final diagnosis was intracranial localized Castleman's disease because the results of the full physical examination and laboratory analyses were normal...
January 2017: No Shinkei Geka. Neurological Surgery
https://www.readbyqxmd.com/read/28100459/clinical-and-pathological-characteristics-of-hiv-and-hhv8-negative-castleman-disease
#3
Li Yu, Meifeng Tu, Jorge Cortes, Zijun Y Xu-Monette, Roberto N Miranda, Jun Zhang, Robert Z Orlowski, Sattva Neelapu, Prajwal C Boddu, Mary A Akosile, Thomas S Uldrick, Robert Yarchoan, L Jeffrey Medeiros, Yong Li, David C Fajgenbaum, Ken H Young
Castleman disease (CD) comprises three poorly-understood lymphoproliferative variants that share several common histopathological features. Unicentric CD (UCD) is localized to a single region of lymph nodes. Multicentric CD (MCD) manifests with systemic inflammatory symptoms and organ dysfunction due to cytokine dysregulation, and involves multiple lymph node regions. Human herpes virus-8 causes MCD (HHV-8-associated MCD) in immunocompromised individuals, such as HIV infected patients. However, greater than 50% MCD cases are HIV and HHV-8 negative, defined as idiopathic (iMCD)...
January 18, 2017: Blood
https://www.readbyqxmd.com/read/28087540/international-evidence-based-consensus-diagnostic-criteria-for-hhv-8-negative-idiopathic-multicentric-castleman-disease
#4
David C Fajgenbaum, Thomas S Uldrick, Adam Bagg, Dale Frank, David Wu, Gordan Srkalovic, David Simpson, Amy Y Liu, David Menke, Shanmuganathan Chandrakasan, Mary Jo Lechowicz, Raymond S M Wong, Sheila Pierson, Michele Paessler, Jean-François Rossi, Makoto Ide, Jason Ruth, Michael Croglio, Alexander Suarez, Vera Krymskaya, Amy Chadburn, Gisele Colleoni, Sunita Nasta, Raj Jayanthan, Christopher S Nabel, Corey Casper, Angela Dispenzieri, Alexander Fosså, Dermot Kelleher, Razelle Kurzrock, Peter Voorhees, Ahmet Dogan, Kazuyuki Yoshizaki, Frits van Rhee, Eric Oksenhendler, Elaine S Jaffe, Kojo S J Elenitoba-Johnson, Megan S Lim
Human Herpesvirus-8(HHV-8)-negative, idiopathic multicentric Castleman disease (iMCD) is a rare and life-threatening disorder involving systemic inflammatory symptoms, polyclonal lymphoproliferation, cytopenias, and multiple organ system dysfunction due to a cytokine storm often including interleukin-6. iMCD accounts for one-third to one-half of all cases of MCD and can occur in individuals of any age. Accurate diagnosis is challenging, as no standard diagnostic criteria or diagnostic biomarkers currently exist, and there is significant overlap with malignant, autoimmune, and infectious disorders...
January 13, 2017: Blood
https://www.readbyqxmd.com/read/28074445/intrathoracic-tumor-of-the-chest-wall-a-case-of-castleman-s-disease-mimicking-myositis-of-the-lower-extremities
#5
Athanasios Tampakis, Ekaterini Christina Tampaki, Thomas Daikeler, Didier Lardinois
Castleman's disease refers to a group of uncommon lymphoproliferative disorders which exhibit common lymph-node histological features. A 72-year-old male patient presented with signs of lower limb myositis. Detailed work-up focused initially on evaluating hematological malignancies, the presence of a solid tumor, autoimmune diseases and degenerative disorders of the peripheral nerves. Finally, a PET-CT scan was performed to exclude paraneoplastic manifestations of a primary tumor, revealing  however a tumor of the thoracic wall...
January 10, 2017: General Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/28060720/inkt-and-memory-b-cells-alterations-in-hhv-8-multicentric-castleman-disease
#6
Zineb Sbihi, Antoine Dossier, David Boutboul, Lionel Galicier, Christophe Parizot, Amandine Emarre, Bénédicte Hoareau, Nicolas Dupin, Anne-Geneviève Marcelin, Anne Oudin, Claire Fieschi, Félix Agbalika, Brigitte Autran, Eric Oksenhendler, Guislaine Carcelain
Human herpesvirus 8 (HHV-8) is the causative agent of Kaposi's sarcoma (KS) and multicentric Castleman disease (MCD), a life-threatening, virally-induced, B-cell lymphoproliferative disorder. HHV-8 is a B-lymphotropic gamma-herpesvirus closely related to the Epstein-Barr virus (EBV). Invariant natural killer T (iNKT) cells are innate-like T cells that play a role in antiviral immunity, specifically in controlling viral replication in EBV-infected B cells. Decline of iNKT cells is associated with age or HIV-infection, both situations associated with HHV-8-related diseases...
November 9, 2016: Blood
https://www.readbyqxmd.com/read/28057712/embolization-of-blood-supply-artery-followed-by-surgery-for-treatment-of-mesorectal-castleman-s-disease-case-report-and-literature-review
#7
Guanyu Yu, Fuao Cao, Haifeng Gong, Peng Liu, Ge Sun, Wei Zhang
A 23-year-old male patient was diagnosed as having a hypervascular pelvic mass by ultrasonography and magnetic resonance examination. A pathology puncture showed vitreous vascular Castleman's disease. Because of concerns about tumor blood supply, embolization under digital subtraction angiography (DSA) was performed on the artery of the pelvic tumor before resection of the mass and surrounding rectum. Castleman's disease of pelvic lymph node (mixed type, mainly hyaline vascular type) was confirmed pathologically from postoperative biopsy...
January 5, 2017: Gastroenterology Report
https://www.readbyqxmd.com/read/28024116/mulberry-cells-in-the-thyroid-warthin-finkeldey-like-cells-in-hashimoto-thyroiditis-associated-lymphoma
#8
Razvan Lapadat, Moon Woo Nam, Swati Mehrotra, Milind Velankar, Stefan E Pambuccian
Warthin-Finkeldey type giant cells were first described in autopsies performed on young children who died during the highly lethal measles epidemic in Palermo during the winter of 1908. The cells had 8-15 nuclei without identifiable cytoplasm within the germinal centers of lymphoid organs resembling megakaryocytes. We describe a case of Hashimoto thyroiditis with an enlarging substernal throid mass. The resection specimen contained many Warthin-Finkeldey-Like Cells (WFLC) in an extranodal marginal zone lymphoma (MALT type) with focal transformation to diffuse large B-cell lymphoma...
December 26, 2016: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/28013535/human-herpes-virus-8-epstein-barr-virus-copositive-plasmablastic-microlymphoma-arising-in-multicentric-castleman-s-disease-of-an-immunocompetent-patient
#9
Yong-Moon Lee, Jin-Man Kim, Sam-Yong Kim
No abstract text is available yet for this article.
January 2017: Journal of Pathology and Translational Medicine
https://www.readbyqxmd.com/read/27999828/a-case-of-abdominal-mesenteric-castleman-s-disease-with-left-renal-cell-carcinoma-and-stomach-leiomyoma
#10
Shunjun Chen, Lele Song, Xinli Xie, Xingmin Han, Bing Cheng
: A rare case of abdominal mesenteric Castleman's disease with left renal cell carcinoma and stomach leiomyoma is reported. A 57 years old male patient was transferred to our hospital for investigation of a left kidney tumor. Physical examination and routine laboratory tests were normal. Multi mode imaging by 64-slices spiral computed tomography (CT) scan, the enhanced CT scan and the fluorine-18-fluorodeoxyglucose positron emission tomography/CT ((18)F-FDG PET/CT) scan were applied. Computed tomography showed a 5...
September 2016: Hellenic Journal of Nuclear Medicine
https://www.readbyqxmd.com/read/27997883/human-immunodeficiency-virus-lymphadenitis-patterns-on-fine-needle-aspiration-cytology
#11
Mona Agnihotri, Leena Naik, Sachin Chaudhari, Kanchan Kothari
OBJECTIVE: The aim of this work was to study the microscopic patterns of human immunodeficiency virus (HIV) lymphadenitis on fine-needle aspiration cytology (FNAC) and correlate them with cluster of differentiation 4 (CD4) counts. STUDY DESIGN: A retrospective study of known HIV-positive patients who underwent lymph node FNAC over a period of 5 years (2009-2013) was undertaken. The cytology slides were retrieved and reviewed. Out of 317 cases, 38 (11.7%) were diagnosed as HIV lymphadenitis...
December 21, 2016: Acta Cytologica
https://www.readbyqxmd.com/read/27989713/castleman-s-disease-presenting-in-the-pelvis
#12
Wang Ping, Xia Dan, Kong Debo, Qin Jie, Mao Yeqing, Wang Shuo
Castleman's disease (CD) is a rare benign lymphoid disorder with unknown etiology. There are two major forms of this disease, unicentric (i.e. localized CD) and multicentric, which play a major role in determining therapy. The mediastinum is the most common localization for the localized CD; while its occurrence in the pelvis is even rarer. We report the case of a 22-year-old woman who had an pelvic mass located in the region of the left iliac fossa. The patient subsequently underwent an robotic-assisted laparoscopic tumorectomy...
December 15, 2016: Urology
https://www.readbyqxmd.com/read/27960263/reactivity-of-metal-clusters
#13
Zhixun Luo, A W Castleman, Shiv N Khanna
We summarize here the research advances on the reactivity of metal clusters. After a simple introduction of apparatuses used for gas-phase cluster reactions, we focus on the reactivity of metal clusters with various polar and nonpolar molecules in the gas phase and illustrate how elementary reactions of metal clusters proceed one-step at a time under a combination of geometric and electronic reorganization. The topics discussed in this study include chemical adsorption, addition reaction, cleavage of chemical bonds, etching effect, spin effect, the harpoon mechanism, and the complementary active sites (CAS) mechanism, among others...
December 14, 2016: Chemical Reviews
https://www.readbyqxmd.com/read/27939464/remote-monitoring-of-blood-pressure-to-reduce-the-risk-of-preeclampsia-related-complications-with-an-innovative-use-of-mobile-technology
#14
R Ganapathy, A Grewal, J S Castleman
OBJECTIVE: Assess suitability of remote self-monitoring of blood pressure with an innovative use of technology in detecting raised blood pressure in pregnancy. STUDY DESIGN: Assess ease of use and safety of the newly developed kit which included a Bluetooth enabled blood pressure machine and an android based mobile phone. The phone was modified to have only one application in it which showed the blood pressure readings with a traffic light system. The study was a proof of concept for wider use of the kit...
October 2016: Pregnancy Hypertension
https://www.readbyqxmd.com/read/27930276/unicentric-castlemans-disease-masquerading-as-a-carcinoid-tumor-of-the-small-intestine
#15
Warqaa Akram, John Degliuomini, Marc K Wallack, Shan Huang, Enyioma Okechukwu, Tam Eric
No abstract text is available yet for this article.
September 2016: American Surgeon
https://www.readbyqxmd.com/read/27904739/review-of-siltuximab-in-the-treatment-of-multicentric-castleman-s-disease
#16
REVIEW
Shayna Sarosiek, Ruchit Shah, Nikhil C Munshi
Castleman's disease (CD) is a rare lymphoproliferative disorder that has multiple histologic patterns, as well as two distinct clinical forms: unicentric or multicentric. Multicentric Castleman's disease (MCD) may have mild symptoms in some cases, but in others it can progress to severe pancytopenia, life-threatening infection, secondary malignancy, multiorgan failure, or death. Recent research has determined that the etiology of the disease signs and symptoms is related to elevated cytokines, including interleukin 6 (IL-6)...
December 2016: Therapeutic Advances in Hematology
https://www.readbyqxmd.com/read/27898752/-tocilizumab-treatment-of-hhv8-positive-hiv-negative-multricentric-plasma-cell-type-castleman-s-disease
#17
Györgyi Mûzes, Judit Csomor, Ferenc Sipos
This is a case presentation of a HHV8-positive multicentric Castleman's disease (MCD) of plasma cell type. The patient failed to respond to combined immunosuppressive therapy and monoclonal anti-CD20 therapy. Interestingly, administration of anti-IL-6R antibody stabilized the disease and resulted in clearance of HHV8 from the involved lymph nodes.
November 29, 2016: Magyar Onkologia
https://www.readbyqxmd.com/read/27893813/azidothymidine-sensitizes-primary-effusion-lymphoma-cells-to-kaposi-sarcoma-associated-herpesvirus-specific-cd4-t-cell-control-and-inhibits-virf3-function
#18
Samantha J Williamson, Samantha M Nicol, Michael Stürzl, Shereen Sabbah, Andrew D Hislop
Kaposi sarcoma-associated herpesvirus (KSHV) is linked with the development of Kaposi sarcoma and the B lymphocyte disorders primary effusion lymphoma (PEL) and multi-centric Castleman disease. T cell immunity limits KSHV infection and disease, however the virus employs multiple mechanisms to inhibit efficient control by these effectors. Thus KSHV-specific CD4+ T cells poorly recognize most PEL cells and even where they can, they are unable to kill them. To make KSHV-infected cells more sensitive to T cell control we treated PEL cells with the thymidine analogue azidothymidine (AZT), which sensitizes PEL lines to Fas-ligand and TRAIL challenge; effector mechanisms which T cells use...
November 2016: PLoS Pathogens
https://www.readbyqxmd.com/read/27891007/multicentric-castleman-s-disease-a-rare-entity-that-mimics-malignancy
#19
Vishak K Acharya, Santosh Rai, Sachin Shirgavi, Radha R Pai, R Anand
No abstract text is available yet for this article.
November 2016: Lung India: Official Organ of Indian Chest Society
https://www.readbyqxmd.com/read/27888220/castleman-s-disease-in-carcinoma-gall-bladder
#20
Vijay Waman Dhakre, Sanjay Nagral, Aditya Jayesh Nanavati
Castleman's disease (CD) also known as angiofollicular lymph node hyperplasia represents a group of uncommon non-clonal lymphoproliferation. We herein report a case of CD associated with carcinoma of the gall bladder. To the best of our knowledge, it is the first of its kind and has not been reported in the past. The hypothesis regarding the aetiopathogenesis of CD is that it is associated with interleukin-6 surges. This may be explained by the overproduction of IL-6 by tumour cells or IL-6 production due to a long-standing/smouldering localised inflammatory response...
November 25, 2016: BMJ Case Reports
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