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https://www.readbyqxmd.com/read/29434951/a-retrospective-study-of-34-patients-with-unicentric-and-multicentric-castleman-s-disease-experience-from-a-single-institution
#1
Jin-Peng Jiang, Xiao-Fei Shen, Jun-Feng Du, Wen-Xian Guan
The aim of the present study was to share the experience of a single institute in the diagnosis, use of accessory examinations and treatment strategies of Castleman's disease (CD). The present study analyzed 34 patients (13 males and 21 females) with CD who were hospitalized between January 2006 and September 2014. The patients were divided into two groups based on the anatomical distribution of the disease: Unicentric CD (UCD) and multicentric CD (MCD). Histological data was obtained from lymph node biopsies...
February 2018: Oncology Letters
https://www.readbyqxmd.com/read/29432340/castleman-s-disease-of-the-kidney-mimicking-renal-cell-carcinoma-on-fdg-pet-ct
#2
Yang Wang, Aisheng Dong, Bo Yang, Jianping Lu
Castleman's disease of the kidney is extremely rare. We present a case of Castleman's disease in the left kidney with multiple para-aortic enlarged lymph nodes. Both the renal lesion and para-aortic lymph nodes showed hypervascularity on enhanced CT and minimally increased FDG uptake on FDG PET/CT, mimicking renal cell carcinoma with para-aortic nodal metastases. This case suggests that Castleman's disease should be considered as a rare differential diagnosis in patients with a hypervascular and hypermetabolic renal lesion...
February 9, 2018: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/29424337/successful-use-of-rituximab-in-glomerular-basement-membrane-nephritis-associated-with%C3%A2-hiv-interstitial-nephritis-secondary-to-castleman-disease%C3%A2
#3
Nathan Calabro, Kammi Henriksen, Seah H Lim, Eric Kerns
We report a case of glomerular basement membrane crescentic glomerulonephritis and multicentric Castleman disease-associated interstitial nephritis in a patient with human immunodeficiency virus (HIV) infection. The patient received corticosteroids, cyclophosphamide, and plasmapheresis, and within 3 weeks, there was worsening thrombocytopenia, anemia, and renal function requiring initiation of hemodialysis. He then received 8 weekly doses of rituximab, and there was steady improvement in renal function, such that he stopped dialysis within 6 weeks and has remained in disease remission at 1-year follow-up...
February 9, 2018: Clinical Nephrology
https://www.readbyqxmd.com/read/29415978/hyaline-vascular-castleman-s-disease-representing-18-trisomy
#4
Masaru Kojima, Seiichi Shimizu
No abstract text is available yet for this article.
February 8, 2018: Journal of Clinical and Experimental Hematopathology: JCEH
https://www.readbyqxmd.com/read/29403325/tafro-syndrome-current-perspectives
#5
REVIEW
Kentaro Sakashita, Kengo Murata, Mikio Takamori
Multicentric Castleman's disease (MCD), a distinct subtype of Castleman's disease, is a rare, nonneoplastic, lymphoproliferative disorder. Patients with MCD present with systemic symptoms and multiple lymphadenopathy. Lymph node biopsy is necessary for the diagnosis of various histological MCD patterns including hyaline vascular, plasma cell, and mixed types. Human herpesvirus 8 (HHV8) infection was identified as an important etiology of MCD among immunocompromised patients such as those positive for human immunodeficiency virus...
2018: Journal of Blood Medicine
https://www.readbyqxmd.com/read/29394794/-a-resected-case-of-castleman-s-disease-that-was-difficult-to-diagnose-preoperatively
#6
Kenji Sakai, Marie Toudou, Yuuhi Shimura, Reyugo Teranishi, Shouhei Takaichi, Chihyon Son, Tomofumi Ohhashi, Hideki Osawa, Hiroshi Noro, Keigo Yasumasa, Takafumi Hirao, Teruo Iwasaki, Yoshikazu Morimoto, Nobutaka Hatanaka, Yoshio Yamasaki
A 70-year-old man was referred to our hospital and admitted after abdominal computed tomography(CT)examination revealed a tumor in the retroperitoneum. The specific blood test findings were poor, and surveillance CT demonstrated a wellcircumscribed, enhanced mass measuring 40mm with calcification behind the horizontal portion of the duodenum. The tumor presented with a slightly high signal in low signal, T2 in T1, and it showed a diffusion decrease in DWI; the simple abdominal MRIrevealed heterogeneous accumulation of SUVmax 3...
November 2017: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29391839/impact-of-siltuximab-on-patient-related-outcomes-in-multicentric-castleman-s-disease
#7
REVIEW
Jenna Sitenga, Gregory Aird, Aabra Ahmed, Peter T Silberstein
Multicentric Castleman's disease (MCD) is a rare, widespread lymphoproliferative disorder and a life-threatening disease involving hyperactivity of the immune system, excessive proinflammatory cytokine release, immune cell proliferation, and organ system dysfunction. Interleukin-6 (IL-6) is a cytokine that plays a key role in the pathogenesis of MCD, as it is involved in the synthesis of acute-phase reactants and aids in the induction of B-cell proliferation. Siltuximab is an anti-IL-6 chimeric monoclonal antibody that acts as a novel treatment modality to bind to IL-6 with high affinity, thus neutralizing the cytokine bioactivity and inhibiting B-cell proliferation...
2018: Patient related Outcome Measures
https://www.readbyqxmd.com/read/29390349/sj%C3%A3-gren-s-syndrome-manifesting-as-clinicopathological-features-of-tafro-syndrome-a-case-report
#8
Shino Fujimoto, Hiroshi Kawabata, Nozomu Kurose, Haruka Kawanami-Iwao, Tomoyuki Sakai, Takafumi Kawanami, Yoshimasa Fujita, Toshihiro Fukushima, Yasufumi Masaki
RATIONALE: TAFRO syndrome is a newly proposed disorder that manifests as thrombocytopenia, anasarca, fever, reticulin myelofibrosis, renal dysfunction, and organomegaly. In this report, we describe the development of severe TAFRO syndrome-like systemic symptoms during the clinical course of juvenile-onset Sjögren's syndrome in a 32-year-old woman. PATIENT CONCERNS: The patient was admitted due to dyspnea, fever, polyarthralgia, and generalized edema. She had been diagnosed with Sjögren's syndrome at the age of 14 years, based on histopathological examination of a biopsy of the minor salivary glands and the development of Raynaud's phenomenon, with no follow-up treatment required...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29389687/tocilizumab-cannot-prevent-the-development-of-bronchiolitis-obliterans-in-patients-with-castleman-disease-associated-paraneoplastic-pemphigus
#9
Liyang Gu, Shuang Ye
No abstract text is available yet for this article.
February 1, 2018: Journal of Clinical Rheumatology: Practical Reports on Rheumatic & Musculoskeletal Diseases
https://www.readbyqxmd.com/read/29380221/chordoid-meningioma-a-clinico-pathological-study-of-an-uncommon-variant-of-meningioma
#10
Nishanth Sadashiva, Rajalakshmi Poyuran, Anita Mahadevan, Dhananjaya I Bhat, Sampath Somanna, Bhagavatula Indira Devi
Chordoid meningioma is a rare variant of meningioma, with a higher incidence in the young and a supposed association with Castleman's syndrome. They have an aggressive clinical course, and are assigned as WHO grade II meningiomas. To the best of our knowledge, 284 chordoid meningiomas have been reported in the literature. This series reporting 33 cases is the third largest series in published literature from a single Institution. We reviewed Clinico-pathological characteristics of 33 patients diagnosed with chordoid meningioma between 2001 and 2015 in our institution...
January 27, 2018: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/29373361/urgent-chemotherapy-in-sepsis-like-shock-related-to-hematologic-malignancies
#11
Marlène Cherruault, Marielle Le Goff, Jérôme Tamburini, Frédéric Pène
OBJECTIVES: Hematologic malignancies may result in multiple organ involvement including pulmonary and renal dysfunctions, and the less common acute circulatory failure. We herein addressed the outcome of patients with sepsis-like shock related to aggressive hematologic malignancies. DESIGN: A 10-year (2007-2016) monocenter retrospective study. SETTINGS: A medical ICU in a tertiary care center. PATIENTS: Patients with circulatory shock requiring vasopressors and who subsequently received chemotherapy...
January 25, 2018: Critical Care Medicine
https://www.readbyqxmd.com/read/29345958/plasma-cell-variant-multicentric-castleman-disease-and-kaposi-s-sarcoma-in-a-treatment-naive-hiv-infected-patient
#12
Anar S Patel, Rachel L Geller, Neela D Goswami
No abstract text is available yet for this article.
January 18, 2018: AIDS Research and Human Retroviruses
https://www.readbyqxmd.com/read/29343584/human-herpesvirus-8-interferon-regulatory-factors-1-and-3-mediate-replication-and-latency-activities-via-interactions-with-usp7-deubiquitinase
#13
Qiwang Xiang, Hyunwoo Ju, Qian Li, Szu-Chieh Mei, Daming Chen, Young Bong Choi, John Nicholas
Human herpesvirus 8 (HHV-8) encodes four viral interferon regulatory factors (vIRFs 1-4) that likely function to suppress innate immune and cellular stress responses through inhibitory interactions with various cellular proteins involved in these activities. It is notable that vIRFs 1 and 4 have been reported to interact with the deubiquitinase USP7, substrates of which include p53 and p53-targeting and destabilizing ubiquitin E3 ligase MDM2. Structural studies of vIRF-1 and vIRF-4 USP7-binding sequences in association with USP7 have been reported; both involve interactions with N-terminal domain residues of USP7, via EGPS and ASTS motifs in vIRF-1 and vIRF-4, respectively, but vIRF-4 residues also contact the catalytic site...
January 17, 2018: Journal of Virology
https://www.readbyqxmd.com/read/29343002/-a-case-of-abdominal-castleman-disease
#14
Y Zhao, Y F Sun, L X Miao
No abstract text is available yet for this article.
January 2, 2018: Zhonghua Er Ke za Zhi. Chinese Journal of Pediatrics
https://www.readbyqxmd.com/read/29334841/tocilizumab-in-the-treatment-of-myocardial-infarction
#15
Matthew B Carroll
Tocilizumab (TCZ) is an important biologic response modifier that Rheumatologists routinely employ in the treatment of several systemic autoimmune diseases. TCZ binds to interleukin (IL)-6 receptors, inhibits cellular activation, and mitigates inflammation by IL-6. In mid-2017 TCZ was approved by the U.S. Food and Drug Administration for its first non-rheumatologic condition, the treatment of chimeric antigen receptor (CAR) T cell-induced severe or life-threatening cytokine release syndrome in patients 2 years of age or older...
January 16, 2018: Modern Rheumatology
https://www.readbyqxmd.com/read/29324586/ten-year-experience-of-transjugular-intrahepatic-portosystemic-shunt-for-noncirrhotic-portal-hypertension
#16
David Regnault, Louis d'Alteroche, Charlotte Nicolas, Fanny Dujardin, Jean Ayoub, Jean Marc Perarnau
BACKGROUND: Transjugular intrahepatic portosystemic shunt (TIPS) is considered to be well suited for the treatment of noncirrhotic portal hypertension (NCPHT) because of a usually severe portal hypertension (PHT) and a mild liver failure, but very less data are available. PATIENTS AND METHODS: Records of patients referred for TIPS between 2004 and 2015 for NCPHT were reviewed. No patient should have clinical or biological or histological features of cirrhosis. RESULTS: Twenty-five patients with a wide variety of histological lesions (sinusoidal dilatations, granulomatosis, regenerative nodular hyperplasia, obliterative portal venopathy, or subnormal liver) and a wide variety of associated diseases (thrombophilia, sarcoidosis, common variable immunodeficiency, scleroderma, Castleman's disease, early primitive biliary cirrhosis, congenital liver fibrosis, chemotherapy, purinethol intake, and congenital varices) were included...
January 10, 2018: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29301533/recurrence-in-unicentric-castleman-s-disease-postoperatively-a-case-report-and-literature-review
#17
Na Ren, Lei Ding, Erna Jia, Jinru Xue
BACKGROUND: Our case describe a rare recurrence case of Unicentric Castleman's disease (UCD) with hyaline vascular type 14 years after surgery. CASE PRESENTATION: A 35-year-old Chinese female was admitted to hospital with one and half months history chest distress and chest pain. Patient reports a history of thoracic operation for mediastinal mass 14 years ago, and it was diagnosed UCD with hyaline vascular type after postoperative pathological examination. At this time, the imaging examination showed a mediastinal mass once again...
January 4, 2018: BMC Surgery
https://www.readbyqxmd.com/read/29277280/lymphadenopathies-in-human-immunodeficiency-virus-infection
#18
REVIEW
Carlos Barrionuevo-Cornejo, Daniela Dueñas-Hancco
This article describes the various non-neoplastic lymphadenopathies that occur in patients infected with the human immunodeficiency virus (HIV), before or during the stage of acquired immunodeficiency syndrome (AIDS). The stages that develop during the HIV infection include: primary infection (acute infection, spread of the virus, development of host immune response, and acute retroviral syndrome), chronic infection or clinical latency, and finally, the AIDS stage. Non-neoplastic lymphadenopathies can occur at any of these phases of the infection and are due to multiple causes that can be divided into infectious causes (bacterial, fungal, parasitic, viral), and reactive causes (persistent generalized lymphadenopathy and a variety of situations that they also occur in immunocompetent people such as Castleman's disease and Kikuchi-Fujimoto's disease, among others)...
December 6, 2017: Seminars in Diagnostic Pathology
https://www.readbyqxmd.com/read/29273069/single-walled-carbon-nanotubes-modulate-pulmonary-immune-responses-and-increase-pandemic-influenza-a-virus-titers-in-mice
#19
Hao Chen, Xiao Zheng, Justine Nicholas, Sara T Humes, Julia C Loeb, Sarah E Robinson, Joseph H Bisesi, Dipesh Das, Navid B Saleh, William L Castleman, John A Lednicky, Tara Sabo-Attwood
BACKGROUND: Numerous toxicological studies have focused on injury caused by exposure to single types of nanoparticles, but few have investigated how such exposures impact a host's immune response to pathogen challenge. Few studies have shown that nanoparticles can alter a host's response to pathogens (chiefly bacteria) but there is even less knowledge of the impact of such particles on viral infections. In this study, we performed experiments to investigate if exposure of mice to single-walled carbon nanotubes (SWCNT) alters immune mechanisms and viral titers following subsequent influenza A virus (IAV) infection...
December 22, 2017: Virology Journal
https://www.readbyqxmd.com/read/29225882/resection-of-unicentric-interlobar-castleman-disease-with-following-adjuvant-radiotherapy
#20
Bruno Sarana, Jana Jaal, Hannes Tamm, Tanel Laisaar
A 22-year-old female patient with rare interlobar unicentric Castleman disease is presented. The tumour was discovered incidentally and thoracoscopic biopsy was planned to rule out malignancy. Due to dense adhesions to the adjacent anatomical structures and diffuse bleeding when mobilizing the tumour, a thoracoscopic approach was converted to thoracotomy. The tumour was removed without lung resection. Adjuvant radiotherapy was used to avoid possible recurrence of the disease. During the follow-up of 6 years, the patient remains free of any symptoms and evidence of recurrence...
2017: SAGE Open Medical Case Reports
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