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A F Y van Wulfften Palthe, N D Clement, O P P Temmerman, B J Burger
BACKGROUND: The primary aim of this study was to identify independent predictors of long-term survivorship after high tibial osteotomy (HTO). The secondary aims were to describe the functional outcome of surviving HTO 10-20 years after surgery. METHODS: A retrospective cohort of 223 HTO that were performed for the treatment of medial osteoarthritis was identified. Details were recorded from the patient notes. All surviving patients were contacted and asked to complete a Tegner Activity Scale, Lysholm Knee Score and rate pain using the Visual Analogue Scale (VAS)...
April 12, 2018: European Journal of Orthopaedic Surgery & Traumatology: Orthopédie Traumatologie
Ewa M Nowosielska, Aneta Cheda, Robert Zdanowski, Sławomir Lewicki, Bobby R Scott, Marek K Janiak
Tritium is a potentially significant source of internal radiation exposure which, at high levels, can be carcinogenic. We evaluated whether single intraperitoneal injection of BALB/c and C57BL/6 mice with tritiated water (HTO) leading to exposure to low (0.01 or 0.1 Gy) and intermediate (1.0 Gy) cumulative whole-body doses of β radiation is immunosuppressive, as judged by enhancement of artificial tumour metastases, functioning of NK lymphocytes and macrophages, circulating cytokine's levels, and numbers of bone marrow, spleen, and peripheral blood cells...
April 6, 2018: Radiation and Environmental Biophysics
O-Sung Lee, Soyeon Ahn, Yong Seuk Lee
The aim of this meta-analysis was to compare the effects of closing-wedge (CW) and opening-wedge (OW) high tibial osteotomies (HTOs) on the change in leg length. Our hypotheses were that leg length will increase after OW HTO and decrease after CW HTO, and the magnitude of the change in leg length would be negligible in both techniques. Multiple databases including MEDLINE, Embase, and Cochrane were searched for studies comparing the change in leg length after HTO with that before HTO. After testing for publication bias and heterogeneity, we aggregated variables by using the random-effects model...
April 4, 2018: Journal of Knee Surgery
Hee-June Kim, Jaeyeong Park, Ji-Yeon Shin, Il-Hyung Park, Kyeong-Hyeon Park, Hee-Soo Kyung
PURPOSE: The purpose of this study was to compare the accuracy of the preoperative planning method using a three-dimensional (3D) printed model with that of a method using picture archiving and communication system (PACS) images in high tibial osteotomy (HTO). METHODS: Patients who underwent HTO using a 3D printed model (20 patients) and a method based on PACS images (20 patients) from 2012 to 2016 were compared. After obtaining the correction angle, in the 3D printed method, the wedge-shaped 3D printed model was designed...
March 30, 2018: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
Marco Cavallo, Sayyed-Hadi Sayyed-Hosseinian, Alessandro Parma, Roberto Buda, Massimiliano Mosca, Sandro Giannini
Background: High tibial osteotomy (HTO) is a recommended treatment for medial compartment knee osteoarthritis. Newer cartilage regenerative procedures may add benefits to the results of HTO. In this prospective study we have investigated the safety and also results of HTO associated with autologous bone marrow derived cells (BMDC) implantation in relatively young and middle aged active individuals with early osteoarthritis of the knee. Methods: A total of 24 patients (mean age of 47...
March 2018: Archives of Bone and Joint Surgery
Yuwei Zhuang, Zhiyong Ren, Lei Jiang, Jiaxiang Zhang, Huafen Wang, Guobao Zhang
Tung oil (TO) was used as a model compound to study two hydroxylated tung oils (HTO), prepared from TO by either aminolysis (HTO-am) or alcoholysis (HTO-al). Main bands in Raman and FTIR spectra were initially assigned based on the detailed analysis of the compound spectra before and after exposure to elevated temperature (200°C). The effect of heat treatment in air on spectral bands, and especially on the changes associated with double bonds, were then investigated. In the present work, changes in spectral bands due to heat treatment were compared with those revealed in the previous work of others...
March 9, 2018: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
Philipp Schuster, Markus Geßlein, Michael Schlumberger, Philipp Mayer, Raul Mayr, Damian Oremek, Sebastian Frank, Martin Schulz-Jahrsdörfer, Jörg Richter
BACKGROUND: High tibial osteotomy (HTO) is a widely used treatment option for medial osteoarthritis and varus malalignment, especially in young patients with early osteoarthritis. Limited outcome data are available for this procedure in severe osteoarthritis, and no long-term data are available using newer implants. PURPOSE: To determine survivorship and functional results of medial open-wedge HTO combined with a chondral resurfacing (CR) procedure (abrasion plus microfracture) in severe medial osteoarthritis (Kellgren-Lawrence grade 3 and 4) and varus malalignment...
March 1, 2018: American Journal of Sports Medicine
Fan Wang, Liming Sun, Yanan Li, Wenwen Zhan, Xiaojun Wang, Xiguang Han
The high activity of exposed facets and large surface area have significant effects on the performance of photocatalysts because most of the photoreactivity properties of materials are related to surface processes. The strategy of combining high-index facets and a hollow structure into one material will provide a new way for designing effective photocatalysts, possessing active exposed facets and a large surface area at the same time. However, fabricating one material with both high-index facets and a hollow structure is still a great challenge due to their thermodynamic instability...
March 27, 2018: Inorganic Chemistry
Anders El-Galaly, Poul T Nielsen, Steen L Jensen, Andreas Kappel
BACKGROUND: High tibial osteotomy (HTO) is a joint preserving treatment of unicompartmental osteoarthritis in the knee. In cases with insufficient or deteriorating clinical results patients may undergo a total knee arthroplasty (TKA). The influence of prior HTO on TKA survival is debated. METHODS: We conducted a population-based registry study comparing 1044 primary TKAs in patients with prior HTO to 63,763 de novo TKAs inserted from 1997 to 2015. Implant survival was estimated by Kaplan-Meier analysis with revision of any kind as endpoint...
February 28, 2018: Journal of Arthroplasty
M Darées, S Putman, T Brosset, T Roumazeille, G Pasquier, H Migaud
INTRODUCTION: Use of a locking plate during medial-opening high tibial osteotomy (HTO) eliminates the need to fill the defect and its associated complications. It also allows early weight bearing. Since long-term data with this type of construct are rare, we wanted to report the outcomes of a 51-patient cohort evaluated after a mean follow-up of 10.2 years. The goals were to determine 1) the HTO survival and whether the correction was maintained between 2 and 10 years later, 2) the stability of the functional outcomes, 3) the complication rate related to use of locking plates...
March 20, 2018: Orthopaedics & Traumatology, Surgery & Research: OTSR
Troy A Roberson, Amit M Momaya, Kyle Adams, Catherine D Long, John M Tokish, Douglas J Wyland
Background: High tibial osteotomy (HTO) is a valuable treatment option in the high-demand patient with chondral damage and an altered mechanical axis. Traditional opening wedge HTO performed with metal plates has several limitations, including hardware irritation, obscuration of detail on magnetic resonance imaging, and complexity of revision surgery. Recently, an all-polyetheretherketone (PEEK) HTO implant was introduced, but no studies to date have evaluated the performance of this implant with minimum 2-year outcomes compared with a traditional metal plate...
March 2018: Orthopaedic Journal of Sports Medicine
Zhi-Peng Wu, Pei Zhang, Jian-Zhong Bai, Yuan Liang, Peng-Tao Chen, Jin-Shan He, Jing-Cheng Wang
BACKGROUND: High tibial osteotomy (HTO) is a usefully surgical procedure to correct the malalignment and delay the progression of osteoarthritis. It is still controversy whether navigation system can offer more accuracy of targeted alignment and achieve better clinical outcomes than conventional method. The purpose of present meta-analysis was to investigate whether navigation system was superior to conventional method with regard to clinical and radiographic outcomes. METHOD: The included studies compared the clinical and radiographic outcomes between navigated HTO group and conventional group...
March 16, 2018: International Journal of Surgery
Patrick J Murphy, Helena Garrido-Hernansaiz, Fiona Mulcahy, David Hevey
This study investigated the associations between forms of HIV-related optimism, HIV-related stigma, and anxiety and depression among HIV-positive men who have sex with men (MSM) in the United Kingdom and Ireland. HIV health optimism (HHO) and HIV transmission optimism (HTO) were hypothesised to be protective factors for anxiety and depression, while the components of HIV-related stigma (enacted stigma, disclosure concerns, concern with public attitudes, and internalised stigma) were hypothesised to be risk factors...
March 1, 2018: AIDS Care
Holly B C Pearson, Lorna J Dallas, Sean D W Comber, Charlotte B Braungardt, Paul J Worsfold, Awadhesh N Jha
Release of tritium (3 H) in the marine environment is of concern with respect to its potential bioaccumulation and detrimental impact on the biota. Previous studies have investigated the uptake and toxicity of this radionuclide in marine mussels, and the interaction of3 H with dissolved organic ligands and elevated temperature. However, despite the well-established view that toxicity is partly governed by chemical speciation, and that toxic effects of mixture of contaminants are not always additive, there have been no studies linking the prevailing chemistry of exposure waters with observed biological effects and tissue specific accumulation of3 H in combination with other constituents commonly found in natural waters...
February 23, 2018: Journal of Environmental Radioactivity
Xavier Paredes-Carnero, Manuel Leyes, Francisco Forriol, Ana Belén Fernández-Cortiñas, Jesús Escobar, Javier G Babé
PURPOSE: Sometimes, total knee replacement (TKR) is performed after a tibial osteotomy. It is not known if the osteotomy influences the clinical process of a TKR. The aim of this study was to look at the clinical outcome of a TKR after high tibial osteotomy (HTO) compared to a TKR with no HTO. METHODS: Between 1995 and 2005, 41 post-HTO TKRs (group A) with a minimum follow-up of ten years were selected. In parallel, it was selected a control group undergoing simple TKR, consisting of 41 patients (group B) matched with group A...
February 20, 2018: International Orthopaedics
G Filardo, S Zaffagnini, R De Filippis, F Perdisa, L Andriolo, C Candrian
PURPOSE: To assess whether the combination of HTO and cartilage treatment produced an additional clinical benefit compared to HTO alone. The secondary aim was to identify if there was any difference among different cartilage procedures in terms of healing potential and clinical outcome. METHODS: A systematic review of the literature was performed on PubMed database by three independent observers according to the following inclusion criteria: clinical reports of any level of evidence, written in the English language, with no time limitation, about HTO associated with cartilage surgical and injective treatment, including surveys reporting clinical, radiological, or second-look outcomes at any follow-up time...
February 16, 2018: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
E Carlos Rodriguez-Merchan
High tibial osteotomy (HTO) is a well established technique for the treatment of medial osteoarthritis of the knee with varus malalignment. The outcome of total knee arthroplasty (TKA) after HTO remains uncertain. The aim of this paper is to revise the literature with the aim of answering the following question: Does a previous (HTO) influence the long-term function or survival of a TKA?. The search engine was MedLine. The keywords used were: total knee arthroplasty after high tibial osteotomy. One hundred and ten articles were found...
January 2018: Archives of Bone and Joint Surgery
Davide Edoardo Bonasia, Federico Dettoni, Anna Palazzolo, Roberto Rossi
High tibial osteotomy (HTO) is a valid treatment option for young active patients with medial tibiofemoral osteoarthrosis (OA) and varus deformity. Sometimes medial OA is combined with symptomatic anterior cruciate ligament (ACL) deficiency. Although isolated HTO (with possible delayed ACL reconstruction) might be indicated in the older population, young active patients may require combined HTO and ACL reconstruction. In addition, an abnormally increased tibial slope may predispose to ACL reconstruction failure and should be addressed for a successful ACL revision...
October 2017: Arthroscopy Techniques
Jennifer Lb Martay, Antony Jr Palmer, Neil K Bangerter, Stuart Clare, A Paul Monk, Cameron P Brown, Andrew J Price
BACKGROUND: High tibial osteotomy (HTO) re-aligns the weight-bearing axis (WBA) of the lower limb. The surgery reduces medial load (reducing pain and slowing progression of cartilage damage) while avoiding overloading the lateral compartment. The optimal correction has not been established. This study investigated how different WBA re-alignments affected load distribution in the knee, to consider the optimal post-surgery re-alignment. METHODS: We collected motion analysis and seven Tesla MRI data from three healthy subjects, and combined this data to create sets of subject-specific finite element models (total=45 models)...
March 2018: Knee
Rene Burchard, Denise Katerla, Marina Hammer, Anke Pahlkötter, Christian Soost, Gerhard Dietrich, Arne Ohrndorf, Wolfgang Richter, Markus Lengsfeld, Hans-Jürgen Christ, Jan Adriaan Graw, Claus-Peter Fritzen
PURPOSE: Opening wedge high tibial osteotomy (HTO) as a treatment in unicompartimental osteoarthritis of the knee can significantly relieve pain and prevent or at least delay an early joint replacement. The fixation of the osteotomy has undergone development and refinements during the last years. The angle-stable plate fixator is currently one of the most commonly used plates in HTOs. The angular stable fixation between screws and the plate offers a high primary stability to retain the correction with early weight-bearing protocols...
February 1, 2018: International Orthopaedics
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