Malvin Jefri, Xin Zhang, Patrick S Stumpf, Li Zhang, Huashan Peng, Nuwan Hettige, Jean-Francois Theroux, Zahia Aouabed, Khadija Wilson, Shriya Deshmukh, Lilit Antonyan, Anjie Ni, Shaima Alsuwaidi, Ying Zhang, Nada Jabado, Benjamin A Garcia, Andreas Schuppert, Hans T Bjornsson, Carl Ernst
Kabuki syndrome (KS) is frequently caused by loss-of-function mutations in one allele of the H3K4 methyltransferase KMT2D and is associated with problems in neurological, immunological, and skeletal system development. We generated heterozygous KMT2D knock-out and Kabuki-patient derived cell models to investigate the role of KMT2D reduced dosage in stem cells. We discovered chromosomal locus-specific alterations in gene expression, specifically a 110Kb region containing SYT3, CLEC11A, C19ORF81, and SHANK1, suggesting locus-specific targeting of KMT2D...
May 28, 2022: Human Molecular Genetics