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https://www.readbyqxmd.com/read/27796303/effects-of-oxytocin-and-vasopressin-on-preferential-brain-responses-to-negative-social-feedback
#1
Marta Gozzi, Erica M Dashow, Audrey Thurm, Susan E Swedo, Caroline F Zink
Receiving negative social feedback can be detrimental to emotional, cognitive, and physical well-being, and fear of negative social feedback is a prominent feature of mental illnesses that involve social anxiety. A large body of evidence has implicated the neuropeptides oxytocin and vasopressin in the modulation of human neural activity underlying social cognition, including negative emotion processing; however, the influence of oxytocin and vasopressin on neural activity elicited during negative social evaluation remains unknown...
November 30, 2016: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/27663941/randomized-controlled-trial-of-intravenous-immunoglobulin-for-pediatric-autoimmune-neuropsychiatric-disorders-associated-with-streptococcal-infections
#2
Kyle A Williams, Susan E Swedo, Cristan A Farmer, Heidi Grantz, Paul J Grant, Precilla D'Souza, Rebecca Hommer, Liliya Katsovich, Robert A King, James F Leckman
OBJECTIVE: Pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections (PANDAS) are hypothesized to occur as a result of cross-reactive antibodies produced in response to group A streptococcal infections. Previous research suggests that immunomodulatory therapies, such as intravenous immunoglobulin (IVIG), may lead to rapid and sustained symptom improvement in patients with PANDAS. METHOD: A total of 35 children meeting criteria for PANDAS and moderate to severe obsessive-compulsive disorder (OCD) were enrolled in a randomized-entry, double-blind, placebo-controlled, 6-week trial of IVIG (1 g/kg/day on 2 consecutive days), followed by optional open-label treatment for nonresponders, with follow-up at 12 and 24 weeks...
October 2016: Journal of the American Academy of Child and Adolescent Psychiatry
https://www.readbyqxmd.com/read/27370066/-evaluation-of-a-neuropsychiatric-disorder-from-pandas-to-pans-and-cans
#3
Muharrem Burak Baytunca, Tuğba Donuk, Serpil Erermiş
PANDAS (Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcal infections) syndrome is a disorder seen before adolescence that possesses an abrupt onset of obsessive-compulsive disorder symptoms and/or tics. Swedo and colleagues defined this disorder in 1998 as a syndrome related to Group A streptoccoccus (GAS) infection with neurological issues, such as motor hyperactivation and choreiform movements. The progress of the disorder may be described as wax-and-waning, apart from abrupt onset, and this relapse and remission course is associated with exacerbating infections, according to the creators of PANDAS syndrome...
2016: Türk Psikiyatri Dergisi, Turkish Journal of Psychiatry
https://www.readbyqxmd.com/read/27356918/idiopathic-autism-cellular-and-molecular-phenotypes-in-pluripotent-stem-cell-derived-neurons
#4
Xiaozhuo Liu, Emilie Campanac, Hoi-Hung Cheung, Mark N Ziats, Lucile Canterel-Thouennon, Margarita Raygada, Vanessa Baxendale, Alan Lap-Yin Pang, Lu Yang, Susan Swedo, Audrey Thurm, Tin-Lap Lee, Kwok-Pui Fung, Wai-Yee Chan, Dax A Hoffman, Owen M Rennert
Autism spectrum disorder is a complex neurodevelopmental disorder whose pathophysiology remains elusive as a consequence of the unavailability for study of patient brain neurons; this deficit may potentially be circumvented by neural differentiation of induced pluripotent stem cells. Rare syndromes with single gene mutations and autistic symptoms have significantly advanced the molecular and cellular understanding of autism spectrum disorders; however, in aggregate, they only represent a fraction of all cases of autism...
June 29, 2016: Molecular Neurobiology
https://www.readbyqxmd.com/read/27178705/csf-concentrations-of-5-methyltetrahydrofolate-in-a-cohort-of-young-children-with-autism
#5
John Shoffner, Barbara Trommer, Audrey Thurm, Cristan Farmer, William A Langley, Laura Soskey, Aldeboran N Rodriguez, Precilla D'Souza, Sarah J Spence, Keith Hyland, Susan E Swedo
OBJECTIVE: To examine the association between cerebral folate deficiency and autism, this study examined CSF 5-methyltetrahydrofolate (5-MTHF) concentrations in a group of young children with autism, investigated the natural variation in CSF 5-MTHF over time, and assessed the relationship between CSF 5-MTHF and symptoms. METHODS: CSF was collected from 67 children with a diagnosis of DSM-IV-TR autistic disorder (age, mean ± SD 43 ± 11 months), with a second CSF sample obtained 1-3 years later on 31 of these subjects (time to follow-up, 30 ± 8 months)...
June 14, 2016: Neurology
https://www.readbyqxmd.com/read/27166296/rapid-eye-movement-sleep-abnormalities-in-children-with-pediatric-acute-onset-neuropsychiatric-syndrome-pans
#6
Thomas Gaughan, Ashura Buckley, Rebecca Hommer, Paul Grant, Kyle Williams, James F Leckman, Susan E Swedo
STUDY OBJECTIVES: Polysomnographic investigation of sleep architecture in children presenting with pediatric acute-onset neuropsychiatric syndrome (PANS). METHODS: Fifteen consecutive subjects meeting criteria for PANS (mean age = 7.2 y; range 3-10 y) underwent single-night full polysomnography (PSG) read by a pediatric neurologist. RESULTS: Thirteen of 15 subjects (87%) had abnormalities detected with PSG. Twelve of 15 had evidence of rapid eye movement (REM) sleep motor disinhibition, as characterized by excessive movement, laughing, hand stereotypies, moaning, or the continuation of periodic limb movements during sleep (PLMS) into REM sleep...
July 15, 2016: Journal of Clinical Sleep Medicine: JCSM: Official Publication of the American Academy of Sleep Medicine
https://www.readbyqxmd.com/read/27096572/creatine-transporter-deficiency-screening-of-males-with-neurodevelopmental-disorders-and-neurocognitive-characterization-of-a-case
#7
Audrey Thurm, Daniel Himelstein, Precilla DʼSouza, Owen Rennert, Susanqi Jiang, Damilola Olatunji, Nicola Longo, Marzia Pasquali, Susan Swedo, Gajja S Salomons, Nuria Carrillo
OBJECTIVE: Creatine transporter deficiency (CTD) is an X-linked, neurometabolic disorder associated with intellectual disability that is characterized by brain creatine (Cr) deficiency and caused by mutations in SLC6A8, the Cr transporter 1 protein gene. CTD is identified by elevated urine creatine/creatinine (Cr/Crn) ratio or reduced Cr peak on brain magnetic resonance spectroscopy; the diagnosis is confirmed by decreased Cr uptake in cultured fibroblasts, and/or identification of a mutation in the SLC6A8 gene...
May 2016: Journal of Developmental and Behavioral Pediatrics: JDBP
https://www.readbyqxmd.com/read/27061356/cortical-thickness-change-in-autism-during-early-childhood
#8
Elizabeth Smith, Audrey Thurm, Deanna Greenstein, Cristan Farmer, Susan Swedo, Jay Giedd, Armin Raznahan
Structural magnetic resonance imaging (MRI) scans at high spatial resolution can detect potential foci of early brain dysmaturation in children with autism spectrum disorders (ASD). In addition, comparison between MRI and behavior measures over time can identify patterns of brain change accompanying specific outcomes. We report structural MRI data from two time points for a total of 84 scans in children with ASD and 30 scans in typical controls (mean age time one = 4.1 years, mean age at time two = 6...
July 2016: Human Brain Mapping
https://www.readbyqxmd.com/read/27053961/development-behavior-and-biomarker-characterization-of-smith-lemli-opitz-syndrome-an-update
#9
Audrey Thurm, Elaine Tierney, Cristan Farmer, Phebe Albert, Lisa Joseph, Susan Swedo, Simona Bianconi, Irena Bukelis, Courtney Wheeler, Geeta Sarphare, Diane Lanham, Christopher A Wassif, Forbes D Porter
BACKGROUND: Smith-Lemli-Opitz syndrome (SLOS) is an autosomal recessive inborn error of cholesterol metabolism syndrome with neurocognitive manifestations. SLOS is the result of mutations in the gene encoding the 7-dehydrocholesterol reductase, which results in the elevation of the cholesterol precursor 7-dehydrocholesterol (7-DHC). Previous reports indicate that intellectual disability, behavioral disturbances, and autism symptoms are frequently part of the SLOS behavioral phenotype...
2016: Journal of Neurodevelopmental Disorders
https://www.readbyqxmd.com/read/26844269/state-dependent-differences-in-functional-connectivity-in-young-children-with-autism-spectrum-disorder
#10
Ashura W Buckley, Rod Scott, Anna Tyler, J Matthew Mahoney, Audrey Thurm, Cristan Farmer, Susan Swedo, Scott A Burroughs, Gregory L Holmes
BACKGROUND: While there is increasing evidence of altered brain connectivity in autism, the degree and direction of these alterations in connectivity and their uniqueness to autism has not been established. The aim of the present study was to compare connectivity in children with autism to that of typically developing controls and children with developmental delay without autism. METHODS: We assessed EEG spectral power, coherence, phase lag, Pearson and partial correlations, and epileptiform activity during the awake, slow wave sleep, and REM sleep states in 137 children aged 2 to 6 years with autism (n = 87), developmental delay without autism (n = 21), or typical development (n = 29)...
December 2015: EBioMedicine
https://www.readbyqxmd.com/read/26366376/no-evidence-of-antibodies-against-gad65-and-other-specific-antigens-in-children-with-autism
#11
Simran Kalra, Peter D Burbelo, Ahmad Bayat, Kathryn H Ching, Audrey Thurm, Michael J Iadarola, Susan E Swedo
BACKGROUND: The presence of autoantibodies has been proposed as evidence for a role of autoimmunity in autism. This report investigates the prevalence of autoantibodies in children with autism using the luciferase immunoprecipitation systems (LIPS) immunoassay technology. A panel of autoantibody targets against several known and candidate neurological autoantigens, autoimmune-associated autoantigens and viruses was employed. METHODS: Serological analysis was performed on typically developing children (n = 55), developmentally delayed children without autism (n = 24) and children diagnosed with autism (n=104)...
December 1, 2015: BBA Clinical
https://www.readbyqxmd.com/read/26231264/evaluation-of-periodic-limb-movements-in-sleep-and-iron-status-in-children-with-autism
#12
Rebecca Lane, Riley Kessler, Ashura Williams Buckley, Alcibiades Rodriguez, Cristan Farmer, Audrey Thurm, Susan Swedo, Barbara Felt
OBJECTIVE: Recent data suggest that both disordered sleep and low serum iron occur more frequently in children with autism compared with children with typical development. Iron deficiency has been linked to specific sleep disorders. The goal of the current study was to evaluate periodic limb movements in sleep and iron status in a group of children with autism compared with typically developing children and children with nonautism developmental delay to determine if iron status correlated with polysomnographic measures of latency and continuity and periodic limb movements in sleep...
October 2015: Pediatric Neurology
https://www.readbyqxmd.com/read/25695941/clinical-presentation-of-pediatric-autoimmune-neuropsychiatric-disorders-associated-with-streptococcal-infections-in-research-and-community-settings
#13
MULTICENTER STUDY
Susan E Swedo, Jakob Seidlitz, Miro Kovacevic, M Elizabeth Latimer, Rebecca Hommer, Lorraine Lougee, Paul Grant
BACKGROUND: The first cases of pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections (PANDAS) were described >15 years ago. Since that time, the literature has been divided between studies that successfully demonstrate an etiologic relationship between Group A streptococcal (GAS) infections and childhood-onset obsessive-compulsive disorder (OCD), and those that fail to find an association. One possible explanation for the conflicting reports is that the diagnostic criteria proposed for PANDAS are not specific enough to describe a unique and homogeneous cohort of patients...
February 2015: Journal of Child and Adolescent Psychopharmacology
https://www.readbyqxmd.com/read/25658609/use-of-intravenous-immunoglobulin-in-the-treatment-of-twelve-youths-with-pediatric-autoimmune-neuropsychiatric-disorders-associated-with-streptococcal-infections
#14
Miro Kovacevic, Paul Grant, Susan E Swedo
This is a case series describing 12 youths treated with intravenous immunoglobulin (IVIG) for pediatric autoimmune neuropsychiatric disorder associated with streptococcal infection (PANDAS). Although it is a clinically based series, the case reports provide new information about the short-term benefits of IVIG therapy, and are the first descriptions of long-term outcome for PANDAS patients.
February 2015: Journal of Child and Adolescent Psychopharmacology
https://www.readbyqxmd.com/read/25658452/therapeutic-plasma-apheresis-as-a-treatment-for-35-severely-ill-children-and-adolescents-with-pediatric-autoimmune-neuropsychiatric-disorders-associated-with-streptococcal-infections
#15
M Elizabeth Latimer, Nathan L'Etoile, Jakob Seidlitz, Susan E Swedo
BACKGROUND: Because of its reported similarities to Sydenham chorea, therapeutic plasma apheresis (TPA) has been proposed as a potential treatment of pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections (PANDAS). To date, support for the use of TPA has been limited to a few anecdotal reports and a small placebo-controlled trial demonstrating dramatic symptom improvements at 1 month and 1 year follow-up. To evaluate the safety and efficacy of TPA further, we undertook a retrospective review of all PANDAS patients treated with TPA at Georgetown University Hospital between August 2009 and October 2013...
February 2015: Journal of Child and Adolescent Psychopharmacology
https://www.readbyqxmd.com/read/25634913/schizophrenia-and-autism-related-disorders
#16
EDITORIAL
Rebecca E Hommer, Susan E Swedo
No abstract text is available yet for this article.
March 2015: Schizophrenia Bulletin
https://www.readbyqxmd.com/read/25484991/social-pragmatic-communication-disorder-a-research-review-of-this-new-dsm-5-diagnostic-category
#17
REVIEW
Lauren B Swineford, Audrey Thurm, Gillian Baird, Amy M Wetherby, Susan Swedo
Social (pragmatic) communication disorder (SCD) is a new diagnostic category in the Diagnostic and Statistical Manual of Mental Disorders, fifth edition (DSM-5). The purpose of this review is to describe and synthesize the relevant literature from language and autism spectrum disorder (ASD) research relating to pragmatic language impairment and other previously used terms that relate to SCD. The long-standing debate regarding how social communication/pragmatic impairments overlap and/or differ from language impairments, ASD, and other neurodevelopmental disorders is examined...
2014: Journal of Neurodevelopmental Disorders
https://www.readbyqxmd.com/read/25325534/clinical-evaluation-of-youth-with-pediatric-acute-onset-neuropsychiatric-syndrome-pans-recommendations-from-the-2013-pans-consensus-conference
#18
Kiki Chang, Jennifer Frankovich, Michael Cooperstock, Madeleine W Cunningham, M Elizabeth Latimer, Tanya K Murphy, Mark Pasternack, Margo Thienemann, Kyle Williams, Jolan Walter, Susan E Swedo
On May 23 and 24, 2013, the First PANS Consensus Conference was convened at Stanford University, calling together a geographically diverse group of clinicians and researchers from complementary fields of pediatrics: General and developmental pediatrics, infectious diseases, immunology, rheumatology, neurology, and child psychiatry. Participants were academicians with clinical and research interests in pediatric autoimmune neuropsychiatric disorder associated with streptococcus (PANDAS) in youth, and the larger category of pediatric acute-onset neuropsychiatric syndrome (PANS)...
February 2015: Journal of Child and Adolescent Psychopharmacology
https://www.readbyqxmd.com/read/25301689/post-infectious-autoimmune-disorders-sydenham-s-chorea-pandas-and-beyond
#19
REVIEW
Kyle A Williams, Susan E Swedo
Infections, and the resulting immune response to these infections, have recently received increased recognition as pathogenic mechanisms for neuropsychiatric disorders. Sydenham's chorea (SC), a widely recognized post-streptococcal autoimmune disorder, represents a model for this proposed pathogenesis. In SC, a dysregulated immune response to a streptococcal infection is hypothesized to result in inflammation of neuronal networks, particularly the basal ganglia nuclei. The resulting dysfunction in the basal ganglia nuclei are hypothesized to lead to a constellation of adventitious movements and psychiatric symptoms, which investigations have shown are amenable to immunomodulatory therapies...
August 18, 2015: Brain Research
https://www.readbyqxmd.com/read/24813812/determination-of-the-allelic-frequency-in-smith-lemli-opitz-syndrome-by-analysis-of-massively-parallel-sequencing-data-sets
#20
J L Cross, J Iben, C L Simpson, A Thurm, S Swedo, E Tierney, J E Bailey-Wilson, L G Biesecker, F D Porter, C A Wassif
Data from massively parallel sequencing or 'Next Generation Sequencing' of the human exome has reached a critical mass in both public and private databases, in that these collections now allow researchers to critically evaluate population genetics in a manner that was not feasible a decade ago. The ability to determine pathogenic allele frequencies by evaluation of the full coding sequences and not merely a single nucleotide polymorphism (SNP) or series of SNPs will lead to more accurate estimations of incidence...
June 2015: Clinical Genetics
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