keyword
MENU ▼
Read by QxMD icon Read
search

Appropriateness

keyword
https://www.readbyqxmd.com/read/27933717/mass-cytometry-analytical-approaches-reveal-cytokine-induced-changes-in-natural-killer-cells
#1
Elena Vendrame, Julia Fukuyama, Dara M Strauss-Albee, Susan Holmes, Catherine A Blish
BACKGROUND: Natural killer (NK) cells have antiviral and antitumor activity that could be harnessed for the treatment of infections and malignancies. To maintain cell viability and enhance antiviral and antitumor effects, NK cells are frequently treated with cytokines. Here we performed an extensive assessment of the effects of cytokines on the phenotype and function of human NK cells. METHODS: We used cytometry by time-of-flight (CyTOF) to evaluate NK cell repertoire changes after stimulation with interleukin (IL)-2, IL-15 or a combination of IL- 12/IL-15/IL-18...
December 9, 2016: Cytometry. Part B, Clinical Cytometry
https://www.readbyqxmd.com/read/27933672/single-neuron-activity-and-theta-modulation-in-the-posterior-parietal-cortex-in-a-visuospatial-attention-task
#2
Fang-Chi Yang, T K Jacobson, R D Burwell
The posterior parietal cortex (PPC) is implicated in directing and maintaining visual attention to locations in space. We hypothesized that the PPC also engages other cognitive processes in the transformation of behaviorally relevant visual inputs into appropriate actions, for example, monitoring of multiple locations, selection of responses to locations in space, and monitoring the outcome of response selections. We recorded single cells and local field potentials in the rat PPC during performance on a novel visuospatial attention (VSA) task that requires visually monitoring locations in space in order to make appropriate stimulus-guided locomotor responses...
December 9, 2016: Hippocampus
https://www.readbyqxmd.com/read/27933577/environmental-and-health-impacts-of-effluents-from-textile-industries-in-ethiopia-the-case-of-gelan-and-dukem-oromia-regional-state
#3
Diriba Dadi, Till Stellmacher, Feyera Senbeta, Steven Van Passel, Hossein Azadi
This study focuses on four textile industries (DH-GEDA, NOYA, ALMHADI, and ALSAR) established between 2005 and 2008 in the peri-urban areas of Dukem and Gelan. The objectives of the study were to generate baseline information regarding the concentration levels of selected pollutants and to analyze their effects on biophysical environments. This study also attempts to explore the level of exposure that humans and livestock have to polluted effluents and the effects thereof. The findings of this study are based on data empirically collected from two sources: laboratory analysis of sample effluents from the four selected textile plants and quantitative as well as qualitative socioeconomic data collection...
January 2017: Environmental Monitoring and Assessment
https://www.readbyqxmd.com/read/27933575/-fast-acting-insulin-new-developments-towards-more-flexibility-for-the-patient
#4
Gerhard W Schmeisl, Yasmin Kretzschmar
BACKGROUND: Post-prandial insulin secretion occurs under physiological conditions very fast and in adequate concentrations. This mechanism is impaired in patients with type 2 diabetes and severe increases of postprandial glucose levels may occur. In order to achieve physiological conditions and to avoid postprandial hyperglycemia, exogenous insulin and insulin analogues should be absorbed very fast and appropriate maximum concentrations should be reached very quickly. METHOD: Overview RESULTS AND CONCLUSIONS: The development of new bolus insulins is focused on improved pharmacokinetic and pharmacodynamic properties...
December 2016: MMW Fortschritte der Medizin
https://www.readbyqxmd.com/read/27933504/mental-health-support-provided-throughout-the-bariatric-surgery-clinical-pathway-in-french-specialized-care-centers-for-obesity
#5
Kristopher Lamore, Sandra S Kaci, Sébastien Czernichow, Marion Bretault, Jean-Luc Bouillot, Anne-Jeanne Naudé, Sandra Gribe-Ouaknine, Claire Carette, Cécile Flahault
OBJECTIVE: Pre-operative psychological assessment is recommended by international guidelines for bariatric surgery candidates. Thereby, service teams caring for bariatric patients should include at least one mental health provider (e.g., a psychologist or psychiatrist). The objective of this study was to evaluate the psychology and psychiatry resources and practices in the 37 specialized obesity centers (CSOs) created by the French Ministry of Health. MATERIALS AND METHODS: CSO coordinators were contacted by e-mail to collect general information on the centers (e...
December 8, 2016: Obesity Surgery
https://www.readbyqxmd.com/read/27933485/fluid-based-biomarkers-for-amyotrophic-lateral-sclerosis
#6
REVIEW
Lucas T Vu, Robert Bowser
Amyotrophic lateral sclerosis (ALS) is a highly heterogeneous disease with no effective treatment. Drug development has been hampered by the lack of biomarkers that aid in early diagnosis, demonstrate target engagement, monitor disease progression, and can serve as surrogate endpoints to assess the efficacy of treatments. Fluid-based biomarkers may potentially address these issues. An ideal biomarker should exhibit high specificity and sensitivity for distinguishing ALS from control (appropriate disease mimics and other neurologic diseases) populations and monitor disease progression within individual patients...
December 8, 2016: Neurotherapeutics: the Journal of the American Society for Experimental NeuroTherapeutics
https://www.readbyqxmd.com/read/27933462/what-do-you-need-to-get-male-partners-of-pregnant-women-tested-for-hiv-in-resource-limited-settings-the-baby-shower-cluster-randomized-trial
#7
Echezona E Ezeanolue, Michael C Obiefune, Wei Yang, Chinenye O Ezeanolue, Jennifer Pharr, Alice Osuji, Amaka G Ogidi, Aaron T Hunt, Dina Patel, Gbenga Ogedegbe, John E Ehiri
Male partner involvement has the potential to increase uptake of interventions to prevent mother-to-child transmission of HIV (PMTCT). Finding cultural appropriate strategies to promote male partner involvement in PMTCT programs remains an abiding public health challenge. We assessed whether a congregation-based intervention, the Healthy Beginning Initiative (HBI), would lead to increased uptake of HIV testing among male partners of pregnant women during pregnancy. A cluster-randomized controlled trial of forty churches in Southeastern Nigeria randomly assigned to either the HBI (intervention group; IG) or standard of care referral to a health facility (control group; CG) was conducted...
December 8, 2016: AIDS and Behavior
https://www.readbyqxmd.com/read/27933459/four-reasons-why-assisted-dying-should-not-be-offered-for-depression
#8
Thomas Blikshavn, Tonje Lossius Husum, Morten Magelssen
Recently, several authors have argued that assisted dying may be ethically appropriate when requested by a person who suffers from serious depression unresponsive to treatment. We here present four arguments to the contrary. First, the arguments made by proponents of assisted dying rely on notions of "treatment-resistant depression" that are problematic. Second, an individual patient suffering from depression may not be justified in believing that chances of recovery are minimal. Third, the therapeutic significance of hope must be acknowledged; when mental healthcare opens up the door to admitting hopelessness, there is a danger of a self-fulfilling prophecy...
December 8, 2016: Journal of Bioethical Inquiry
https://www.readbyqxmd.com/read/27933409/imaging-trends-in-suspected-appendicitis-a-canadian-perspective
#9
Victoria F Tan, Michael N Patlas, Douglas S Katz
PURPOSE: The purpose of our study was to assess trends in the imaging of suspected appendicitis in adult patients in emergency departments of academic centers in Canada. METHODS: A questionnaire was sent to all 17 academic centers in Canada to be completed by a radiologist who works in emergency radiology. The questionnaires were sent and collected over a period of 4 months from October 2015 to February 2016. RESULTS: Sixteen centers (94%) responded to the questionnaire...
December 8, 2016: Emergency Radiology
https://www.readbyqxmd.com/read/27933347/-appropriate-application-of-speech-audiometry
#10
EDITORIAL
T Rahne
No abstract text is available yet for this article.
December 8, 2016: HNO
https://www.readbyqxmd.com/read/27933311/contribution-of-cerebellar-loops-to-action-timing
#11
Ramanujan T Raghavan, Vincent Prevosto, Marc A Sommer
Recent studies of sensorimotor processing have benefited from decision-making paradigms that emphasize the selection of appropriate movements. Selecting when to make those responses, or action timing, is important as well. Although the cerebellum is commonly viewed as a controller of movement dynamics, its role in action timing is also firmly supported. Several lines of research have now extended this idea. Anatomical findings have revealed connections between the cerebellum and broader timing circuits, neurophysiological results have suggested mechanisms for timing within its microcircuitry, and theoretical work has indicated how temporal signals are processed through it and decoded by its targets...
April 2016: Current Opinion in Behavioral Sciences
https://www.readbyqxmd.com/read/27933268/autologous-platelet-lysates-local-injections-for-treatment-of-tibia-non-union-with-breakage-of-the-nickelclad-a-case-report
#12
Hong-Jiang Jiang, Xun-Xiang Tan, Hai-Yang Ju, Jin-Ping Su, Wei Yan, Xiu-Gang Song, Li-Wu Qin, Chang-Jun Ju, Ling-Shuang Wang, De-Bao Zou
BACKGROUND: Nonunions of the tibia represent challenging orthopedic problems, which require the surgeon to analyze numerous factors and choose an appropriate treatment. This article presents a case report of tibia and fibula fracture patient who failed the internal fixation surgery and successfully recovered after one course of percutaneous autologous platelet lysates injection. CASE DESCRIPTION: The patient received an internal nickelclad breakage at 9 months post-surgery but reluctant to accept a second surgery, then autologous platelet lysates (APL) injection which is a less invasive method was recommended...
2016: SpringerPlus
https://www.readbyqxmd.com/read/27933259/deformity-correction-and-extremity-lengthening-in-the-lower-leg-comparison-of-clinical-outcomes-with-two-external-surgical-procedures
#13
Eugen Reitenbach, Robert Rödl, Georg Gosheger, Björn Vogt, Frank Schiedel
OBJECTIVE: Distraction osteogenesis is a method of stimulating the growth of new bone tissue in order to lengthen the extremities or bridge resected bone defects. In addition to the now-established intramedullary procedures, two different fixator systems are in use. The present study investigated the classical Ilizarov ring fixator (IRF) and a hexapod to assess the precision of lower-leg lengthening and complications classified using the Paley criteria for problems, obstacles, and complications...
2016: SpringerPlus
https://www.readbyqxmd.com/read/27933231/intuitionistic-fuzzy-based-model-for-failure-detection
#14
Daniel O Aikhuele, Faiz B M Turan
In identifying to-be-improved product component(s), the customer/user requirements which are mainly considered, and achieved through customer surveys using the quality function deployment (QFD) tool, often fail to guarantee or cover aspects of the product reliability. Even when they do, there are always many misunderstandings. To improve the product reliability and quality during product redesigning phase and to create that novel product(s) for the customers, the failure information of the existing product, and its component(s) should ordinarily be analyzed and converted to appropriate design knowledge for the design engineer...
2016: SpringerPlus
https://www.readbyqxmd.com/read/27933230/maximum-likelihood-based-analysis-of-equally-spaced-longitudinal-count-data-with-first-order-antedependence-and-overdispersion
#15
Victoria Gamerman, Matthew Guerra, Justine Shults
This manuscript implements a maximum likelihood based approach that is appropriate for equally spaced longitudinal count data with over-dispersion, so that the variance of the outcome variable is larger than expected for the assumed Poisson distribution. We implement the proposed method in the analysis of seizure data and a subset of German Socio-Economic Panel data. To demonstrate the importance of correctly modeling the over-dispersion, we make comparisons with the semi-parametric generalized estimating equations approach that incorrectly ignores any over-dispersion in the data...
2016: SpringerPlus
https://www.readbyqxmd.com/read/27933213/molecular-pathology-of-cancer-how-to-communicate-with-disease
#16
REVIEW
Peter Birner, Gerald Prager, Berthold Streubel
: Recent technical advances have brought insights into the biology of cancer in human, establishing it as a disease driven by genetic mutations. Beside inherited family tumour syndromes caused by germline mutations, somatic genetic alterations occur early in tumourigenesis, which accumulate during the progression of the disease and its treatment. Based on these observations, medical oncology has started to enter an era of stratified medicine, where treatment selection is becoming tailored to drugable molecular pathways...
2016: ESMO Open
https://www.readbyqxmd.com/read/27933188/quality-of-care-in-rural-youth-with-type-1-diabetes-a-cross-sectional-pilot-assessment
#17
Kyle S Stumetz, Joyce P Yi-Frazier, Connor Mitrovich, Kathaleen Briggs Early
BACKGROUND: Type 1 diabetes mellitus (T1DM) presents a significant health burden for patients and families. The quality of care (QOC) among those living in rural communities is thought to be subpar compared with those in urban communities; however, little data exist to reflect this, especially in pediatric diabetes. OBJECTIVE: The purpose of this pilot study was to investigate diabetes QOC among families living in rural versus urban areas. 6 QOC markers were used to compare youth with T1DM: appointment adherence, patient-provider communication, diabetes education during clinic visit, congruency with diabetes standards of care, diabetes self-management behaviors, and diabetes-related hospitalizations...
2016: BMJ Open Diabetes Research & Care
https://www.readbyqxmd.com/read/27933184/coxsackie-adenovirus-receptor-expression-is-enhanced-in-pancreas-from-patients-with-type-1-diabetes
#18
M Hodik, M Anagandula, J Fuxe, L Krogvold, K Dahl-Jørgensen, H Hyöty, L Sarmiento, G Frisk
OBJECTIVES: One of the theories connecting enterovirus (EV) infection of human islets with type 1 diabetes (T1D) is the development of a fertile field in the islets. This implies induction of appropriate proteins for the viral replication such as the coxsackie-adenovirus receptor (CAR). The aim of this study was to investigate to what extent CAR is expressed in human islets of Langerhans, and what conditions that would change the expression. DESIGN: Immunohistochemistry for CAR was performed on paraffin-embedded pancreatic tissue from patients with T1D (n=9 recent onset T1D, n=4 long-standing T1D), islet autoantibody-positive individuals (n=14) and non-diabetic controls (n=24) individuals...
2016: BMJ Open Diabetes Research & Care
https://www.readbyqxmd.com/read/27933178/assessing-medication-packaging-and-labelling-appropriateness-in-sri-lanka
#19
N Athuraliya, E J Walkom, S Dharmaratne, J Robertson
BACKGROUND: There is substantial evidence of poor dispensing practices with inadequate packaging and labelling of medicines, and limited advice on their usage in low and middle-income countries (LMICs). We examined the labelling and packaging of medicines identified during a survey of 1322 households in six regions of Sri Lanka between 2010 and 2013 conducted using the World Health Organization (WHO) methodology for household surveys. We compared medicines obtained from public and private sources and asked interviewees if they understood how to take the medicines...
2016: Journal of Pharmaceutical Policy and Practice
https://www.readbyqxmd.com/read/27933166/sex-specific-ecophysiological-responses-to-environmental-fluctuations-of-free-ranging-hermann-s-tortoises-implication-for-conservation
#20
Adélaïde Sibeaux, Catherine Louise Michel, Xavier Bonnet, Sébastien Caron, Kévin Fournière, Stephane Gagno, Jean-Marie Ballouard
Physiological parameters provide indicators to evaluate how organisms respond to conservation actions. For example, individuals translocated during reinforcement programmes may not adapt to their novel host environment and may exhibit elevated chronic levels of stress hormones and/or decreasing body condition. Conversely, successful conservation actions should be associated with a lack of detrimental physiological perturbation. However, physiological references fluctuate over time and are influenced by various factors (e...
2016: Conservation Physiology
keyword
keyword
20730
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"