keyword
https://read.qxmd.com/read/38537216/unusual-renal-uptake-of-131i-mibg-in-a-young-hypertensive-with-renal-artery-stenosis
#1
JOURNAL ARTICLE
Agrawal Roopal, Malhotra Gaurav
A 10-year-old hypertensive girl underwent 131I-MIBG scan to rule out neural crest derived tumor. The whole-body images revealed diffuse intense tracer uptake in the right kidney, which persisted in 96-hour images as well. CT renal angiography revealed 90% to 95% right renal artery stenosis. Thereafter, she underwent baseline and angiotensin receptor blockade renal dynamic imaging, which revealed hemodynamically significant renal artery stenosis. Pattern of diffuse and intense 131I-MIBG uptake, albeit rare, still warrants further evaluation to rule out renal artery stenosis and investigate its hemodynamic significance for appropriate management...
March 25, 2024: Clinical Nuclear Medicine
https://read.qxmd.com/read/38537138/it-s-a-trap-an-approachable-guide-to-constructing-and-using-rotating-arm-air-samplers
#2
JOURNAL ARTICLE
Jill C Check, Rebecca Harkness, Lexi Heger, Martin I Chilvers, Walter F Mahaffee, Monique L Sakalidis, Timothy D Miles
An increasing number of researchers are looking to understand the factors affecting microbial dispersion but are often limited by the costs of commercially available air samplers. Some have reduced these costs by designing self-made versions, however there are no published sampler designs and there is limited information provided on the actual construction process. Lack of appropriate reference material limits the use of these self-made samplers by many researchers. This manuscript provides a guide to designing and constructing rotating-arm impaction air samplers by covering 1) environmental considerations; 2) construction materials and equipment; 3) the construction process; and 4) air sampler deployment...
March 27, 2024: Plant Disease
https://read.qxmd.com/read/38537114/should-research-administrators-be-regulated-as-carefully-as-researchers
#3
JOURNAL ARTICLE
Jason Scott Robert
This essay assesses the rationale for regulating research administrators as carefully as they regulate researchers. The reasons for such regulation are identical: protecting scientific integrity, ensuring responsible use of public funds, addressing the lack of effective recourse for victims, creating negative consequences for misbehaving actors, and addressing high incentives for misconduct. Whereas the reasons compelling us to regulate research administrators are obvious, counterarguments to administrative oversight are based on suggestions that the incidence and prevalence of cases of administrative misconduct are too low to warrant formal regulation...
March 27, 2024: BioEssays: News and Reviews in Molecular, Cellular and Developmental Biology
https://read.qxmd.com/read/38537082/khmer-translation-and-cultural-adaptation-of-the-locomotor-capabilities-index-5
#4
JOURNAL ARTICLE
Nerrolyn Ramstrand, Alan Maddock, Thearith Heang, Nil Ean, Sisary Kheng
BACKGROUND: Mobility is a major goal of prosthetic and orthotic rehabilitation, and use of outcome measures to evaluate mobility is necessary for good clinical practice. To support the use of outcome measures worldwide, work is needed to translate relevant instruments and adapt them for use in multiple cultures. OBJECTIVES: The objective of this research was to use a standardized method to translate the Locomotor Capabilities Index-5 (LCI-5) into Khmer, the national language in Cambodia, and to evaluate its cultural integrity by assessing it with a group of prosthesis and orthosis users...
March 22, 2024: Prosthetics and Orthotics International
https://read.qxmd.com/read/38537074/development-of-the-psu-child-pump
#5
JOURNAL ARTICLE
Christopher Scheib, Raymond Newswanger, Joshua Cysyk, Karl Bohnenberger, Branka Lukic, Lichong Xu, Eric Yeager, Kirby Bletcher, Patrick Leibich, Quandashia Jackson, Heidi Flory, Mindy Tillinger, William Weiss, Gerson Rosenberg, Choon-Sik Jhun
The Pennsylvania State University (PSU) Child Pump, a centrifugal continuous-flow ventricular assist device (cf-VAD), is being developed as a suitable long-term implantable device for pediatric heart failure patients between 10 and 35 kg, body surface area (BSA) of 0.5-1.2 m2, 1-11 years of age, and requiring a mean cardiac output of 1.0-3.5 L/min. In-vitro hydraulic and hemodynamic performances were evaluated on a custom mock circulatory loop with ovine blood. Normalized index of hemolysis (NIH) was evaluated under four conditions: 1) 8,300 rpm, 3...
March 28, 2024: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
https://read.qxmd.com/read/38537034/translation-and-measurement-properties-of-the-portuguese-brazil-version-of-the-hammersmith-infant-neurological-examination-hine-br
#6
JOURNAL ARTICLE
Michelle Alexandrina Dos Santos Furtado, Hércules Ribeiro Leite, Matheus Rocha Pereira Klettenberg, Victor Alves Rodrigues, Lisiane Seguti Ferreira, Melina Rodero Marques, Isadora de Oliveira Cavalcante, Tamires Saboia Santos, Tathiana Ghisi de Souza, Ayrles Silva Gonçalves Barbosa Mendonça, Ana Cristina Resende Camargos, Kênnea Martins Almeida Ayupe
OBJECTIVE: The current study aimed to translate the Hammersmith Infant Neurological Examination (HINE) into Brazilian Portuguese and analyze the reliability of the translated version for a population of Brazilian infants. METHODS: This was a methodological study, approved by the Ethics Committee, carried out between June 2020 and May 2021. HINE is a standardized clinical neurological examination used for the early detection of cerebral palsy. The quantitative section, "neurological examination", contains 26 items scored from 0 to 3 points, divided into five categories: cranial nerve function, posture, movements, muscle tone and reflexes, and reactions...
2024: Revista Paulista de Pediatria: Orgão Oficial da Sociedade de Pediatria de São Paulo
https://read.qxmd.com/read/38536889/multilocus-sequence-typing-and-antibiotic-resistance-of-aeromonas-isolated-from-freshwater-fish-in-hebei-province
#7
JOURNAL ARTICLE
Zixiao Yu, Yunseok Oh, Songmi Kim, Kyudong Han, Kornsorn Srikulnath, Qingyang Li, Ji-Seok Jang, Ho-Seong Lee
Aeromonas spp. are the opportunistic pathogens that infect both aquatic and terrestrial homeotherms. They were commonly present in aquatic environments, including effluent, tap water, marine, river, and lake, where they are often isolated from aquatic animals, including fish, molluscs, and crustaceans. The Aeromonas infections can cause sepsis, ulcer, and other symptoms, resulting in the death of massive aquatic animals. Therefore, the prevention and control of Aeromonas is of great significance for the healthy development of aquaculture...
2024: PloS One
https://read.qxmd.com/read/38536877/comparative-study-on-differential-expression-analysis-methods-for-single-cell-rna-sequencing-data-with-small-biological-replicates-based-on-single-cell-transcriptional-data-of-pbmcs-from-covid-19-severe-patients
#8
JOURNAL ARTICLE
Jie Xue, Xinfan Zhou, Jing Yang, Adan Niu
Single-cell RNA sequencing (scRNA-seq) is a high-throughput experimental technique for studying gene expression at the single-cell level. As a key component of single-cell data analysis, differential expression analysis (DEA) serves as the foundation for all subsequent secondary studies. Despite the fact that biological replicates are of vital importance in DEA process, small biological replication is still common in sequencing experiment now, which may impose problems to current DEA methods. Therefore, it is necessary to conduct a thorough comparison of various DEA approaches under small biological replications...
2024: PloS One
https://read.qxmd.com/read/38536790/cause-and-preventability-of-in-hospital-mortality-after-pci-a-statewide-root-cause-analysis-of-1-163-deaths
#9
JOURNAL ARTICLE
Francesco Moroni, Milan Seth, Hameem U Changezi, Milind Karve, Dilip S Arora, Manoj Sharma, Elizabeth Pielsticker, Aaron D Berman, Daniel Lee, M Imran Qureshi, Lorenzo Azzalini, Devraj Sukul, Hitinder S Gurm
BACKGROUND: Mortality is the most devastating complication of percutaneous coronary interventions (PCI). Identifying the most common causes and mechanisms of death after PCI in contemporary practice is an important step in further reducing periprocedural mortality. OBJECTIVES: To systematically analyze the cause and circumstances of in-hospital mortality in a large, multi-center, statewide cohort. METHODS: In-hospital deaths after PCI occurring at 39 hospitals included in the Blue Cross Blue Shield of Michigan Cardiovascular Consortium (BMC2) between 2012 and 2014 were retrospectively reviewed using validated methods...
2024: PloS One
https://read.qxmd.com/read/38536787/multiple-cardiovascular-risk-factor-care-in-55-low-and-middle-income-countries-a-cross-sectional-analysis-of-nationally-representative-individual-level-data-from-280-783-adults
#10
JOURNAL ARTICLE
Alpha Oumar Diallo, Maja E Marcus, David Flood, Michaela Theilmann, Nicholas E Rahim, Alan Kinlaw, Nora Franceschini, Til Stürmer, Dessie V Tien, Mohsen Abbasi-Kangevari, Kokou Agoudavi, Glennis Andall-Brereton, Krishna Aryal, Silver Bahendeka, Brice Bicaba, Pascal Bovet, Maria Dorobantu, Farshad Farzadfar, Seyyed-Hadi Ghamari, Gladwell Gathecha, David Guwatudde, Mongal Gurung, Corine Houehanou, Dismand Houinato, Nahla Hwalla, Jutta Jorgensen, Gibson Kagaruki, Khem Karki, Joao Martins, Mary Mayige, Roy Wong McClure, Sahar Saeedi Moghaddam, Omar Mwalim, Kibachio Joseph Mwangi, Bolormaa Norov, Sarah Quesnel-Crooks, Abla Sibai, Lela Sturua, Lindiwe Tsabedze, Chea Wesseh, Pascal Geldsetzer, Rifat Atun, Sebastian Vollmer, Till Bärnighausen, Justine Davies, Mohammed K Ali, Jacqueline A Seiglie, Emily W Gower, Jennifer Manne-Goehler
The prevalence of multiple age-related cardiovascular disease (CVD) risk factors is high among individuals living in low- and middle-income countries. We described receipt of healthcare services for and management of hypertension and diabetes among individuals living with these conditions using individual-level data from 55 nationally representative population-based surveys (2009-2019) with measured blood pressure (BP) and diabetes biomarker. We restricted our analysis to non-pregnant individuals aged 40-69 years and defined three mutually exclusive groups (i...
2024: PLOS Glob Public Health
https://read.qxmd.com/read/38536782/a-machine-learning-based-depression-screening-framework-using-temporal-domain-features-of-the-electroencephalography-signals
#11
JOURNAL ARTICLE
Sheharyar Khan, Sanay Muhammad Umar Saeed, Jaroslav Frnda, Aamir Arsalan, Rashid Amin, Rahma Gantassi, Sadam Hussain Noorani
Depression is a serious mental health disorder affecting millions of individuals worldwide. Timely and precise recognition of depression is vital for appropriate mediation and effective treatment. Electroencephalography (EEG) has surfaced as a promising tool for inspecting the neural correlates of depression and therefore, has the potential to contribute to the diagnosis of depression effectively. This study presents an EEG-based mental depressive disorder detection mechanism using a publicly available EEG dataset called Multi-modal Open Dataset for Mental-disorder Analysis (MODMA)...
2024: PloS One
https://read.qxmd.com/read/38536770/a-co-reactive-immunosensor-based-on-ti-3-c-2-t-x-mxene-tio-2-mos-2-hybrids-promoting-luminol-au-ni-co-ncs-electrochemiluminescence-for-cyfra-21-1-detection
#12
JOURNAL ARTICLE
Xiang Ren, Mingyue Shao, Zuoxun Xie, Xiaojian Li, Hongmin Ma, Dawei Fan, Jinxiu Zhao, Qin Wei
The construction of assays is capable of accurately detecting cytokeratin-19 (CYFRA 21-1), which is critical for the rapid diagnosis of nonsmall cell lung cancer. In this work, a novel electrochemiluminescence (ECL) immunosensor based on the co-reaction promotion of luminol@Au@Ni-Co nanocages (NCs) as ECL probe by Ti3 C2 T x MXene@TiO2 -MoS2 hybrids as co-reaction accelerator was proposed to detect CYFRA 21-1. Ni-Co NCs, as a derivative of Prussian blue analogs, can be loaded with large quantities of Au NPs, luminol, and CYFRA 21-1 secondary antibodies due to their high specific surface area...
March 27, 2024: ACS Sensors
https://read.qxmd.com/read/38536688/development-and-evaluation-of-a-learning-based-model-for-real-time-haptic-texture-rendering
#13
JOURNAL ARTICLE
Negin Heravi, Heather Culbertson, Allison M Okamura, Jeannette Bohg
Current Virtual Reality (VR) environments lack the haptic signals that humans experience during real-life interactions, such as the sensation of texture during lateral movement on a surface. Adding realistic haptic textures to VR environments requires a model that generalizes to variations of a user's interaction and to the wide variety of existing textures in the world. Current methodologies for haptic texture rendering exist, but they usually develop one model per texture, resulting in low scalability. We present a deep learning-based action-conditional model for haptic texture rendering and evaluate its perceptual performance in rendering realistic texture vibrations through a multi-part human user study...
March 27, 2024: IEEE Transactions on Haptics
https://read.qxmd.com/read/38536677/simple-inverse-kinematics-computation-considering-joint-motion-efficiency
#14
JOURNAL ARTICLE
Ansei Yonezawa, Heisei Yonezawa, Itsuro Kajiwara
Inverse kinematics (IK) is an important and challenging problem in the operation of industrial manipulators. This study proposes a simple IK calculation scheme for an industrial serial manipulator. The proposed technique can calculate appropriate values of the joint variables to realize the desired end-effector position and orientation while considering the motion costs of each joint. Two scalar functions are defined for the joint variables: one is to evaluate the end-effector position and orientation, whereas the other is to evaluate the motion efficiency of the joints...
March 27, 2024: IEEE Transactions on Cybernetics
https://read.qxmd.com/read/38536646/impact-of-immunosuppressed-status-on-prognosis-of-carbapenem-resistant-organisms-bloodstream-infections
#15
JOURNAL ARTICLE
Yuan-Yuan Li, Yan Chen, Shan Li, Yuan-Yuan Li, Ran An, Xiao-Yun Hu, Wei Jiang, Chun-Yao Wang, Run Dong, Qi-Wen Yang, Li Weng, Jin-Min Peng, Bin Du
INTRODUCTION: The impact of immunosuppression on prognosis of carbapenem-resistant organism (CRO) bloodstream infection (BSI) remains unclear. The aim of this study was to clarify the relationship between immunosuppression and mortality of CRO-BSI and to identify the risk factors associated with mortality in immunosuppressed patients. METHODS: This retrospective study included 279 patients with CRO-BSI from January 2018 to March 2023. Clinical characteristics and outcomes were compared between the immunosuppressed and immunocompetent patients...
March 27, 2024: Infectious Diseases and Therapy
https://read.qxmd.com/read/38536637/an-exploration-of-online-and-in-person-administration-of-the-kaufman-brief-intelligence-test-second-edition-kbit-2-in-children-and-adolescents-being-evaluated-for-autism-spectrum-disorder
#16
JOURNAL ARTICLE
Joshua Anbar, Maurice Metoyer, Christopher J Smith, Nicole L Matthews
PURPOSE:  Most assessment tools used to diagnose and characterize autism spectrum disorder (ASD) were developed for in-person administration. The coronavirus disease 2019 (COVID-19) pandemic resulted in the need to adapt traditional assessment tools for online administration with only minimal evidence to support validity of such practices. METHODS: The current exploratory study compared scores from online administration of the Kaufman Brief Intelligence Test, Second Edition (KBIT-2) during the pandemic to scores derived from follow-up testing using traditional in-person administration...
March 27, 2024: Journal of Autism and Developmental Disorders
https://read.qxmd.com/read/38536632/estimation-of-organ-and-effective-doses-of-cbct-scans-of-radiotherapy-using-size-specific-field-of-view-fov-a-monte-carlo-study
#17
JOURNAL ARTICLE
Abdullah Abuhaimed, Huda Mujammami, Khaled AlEnazi, Ahmed Abanomy, Yazeed Alashban, Colin J Martin
The kV cone beam computed tomography (CBCT) is one of the most common imaging modalities used for image-guided radiation therapy (IGRT) procedures. Additional doses are delivered to patients, thus assessment and optimization of the imaging doses should be taken into consideration. This study aimed to investigate the influence of using fixed and patient-specific FOVs on the patient dose. Monte Carlo simulations were performed to simulate kV beams of the imaging system integrated into Truebeam linear accelerator using BEAMnrc code...
March 27, 2024: Physical and engineering sciences in medicine
https://read.qxmd.com/read/38536615/quantification-of-unencapsulated-drug-in-target-tissues-demonstrates-pharmacological-properties-and-therapeutic-effects-of-liposomal-topotecan-ff-10850
#18
JOURNAL ARTICLE
Toshifumi Kimura, Ken Okada, Yasushi Morohashi, Yukio Kato, Mikinaga Mori, Hiroshi Kato, Takeshi Matsumoto, Susumu Shimoyama
PURPOSE: Quantifying unencapsulated drug concentrations in tissues is crucial for understanding the mechanisms underlying the efficacy and safety of liposomal drugs; however, the methodology for this has not been fully established. Herein, we aimed to investigate the enhanced therapeutic potential of a pegylated liposomal formulation of topotecan (FF-10850) by analyzing the concentrations of the unencapsulated drug in target tissues, to guide the improvement of its dosing regimen. METHODS: We developed a method for measuring unencapsulated topotecan concentrations in tumor and bone marrow interstitial fluid (BM-ISF) and applied this method to pharmacokinetic assessments...
March 27, 2024: Pharmaceutical Research
https://read.qxmd.com/read/38536588/image-quality-enhancement-for-digital-breast-tomosynthesis-high-density-object-artifact-reduction
#19
JOURNAL ARTICLE
Enxiang Shen, Caozhe Li, Kanglian Zhao, Jie Yuan, Paul Carson
Breast cancer has a high incidence and mortality rate among women, early diagnosis is essential as it gives insight regarding the most appropriate therapeutic strategy for each case. Among all imaging diagnostic methods, digital breast tomosynthesis (DBT) is effective for early breast cancer detection. In DBT images, high-density object artifacts are generated when imaging objects with high X-ray absorptivity, which include metal artifacts, ripple artifacts, and deformation artifacts. In this study, we analyze the causes of these artifacts and propose a set of high-density object reconstruction methods based on iterative algorithms...
March 27, 2024: J Imaging Inform Med
https://read.qxmd.com/read/38536586/prevalence-of-and-factors-associated-with-financial-toxicity-after-pancreatectomy-and-gastrectomy
#20
JOURNAL ARTICLE
Yuki Hirata, Connie To, Heather Lyu, Grace L Smith, Joyce P Samuel, Hop S Tran Cao, Brian D Badgwell, Matthew H G Katz, Naruhiko Ikoma
BACKGROUND: Financial toxicity (FT) refers to the adverse impact of cancer treatment costs on patients' experiences, potentially leading to poor adherence to treatment and outcomes. However, the prevalence of FT among patients undergoing major upper gastrointestinal cancer operations, as well as factors associated with FT, remain unclear. METHODS: We conducted a cross-sectional study by sending the Comprehensive Score for financial Toxicity (COST) survey and Surgery-Q (a survey specifically developed for this study) to patients who underwent gastrectomy or pancreatectomy for malignant disease at our institution in 2019-2021...
March 27, 2024: Annals of Surgical Oncology
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