keyword
https://read.qxmd.com/read/38496631/discover-overlooked-complications-after-preeclampsia-using-electronic-health-records
#21
Lana Garmire, Haoming Zhu, Xiaotong Yang, Wanling Xie, Elizabeth Langen, Ruowang Li
Background Preeclampsia (PE) is a severe pregnancy complication characterized by hypertension and end-organ damage such as proteinuria. PE poses a significant threat to women's long-term health, including an increased risk of cardiovascular and renal diseases. Most previous studies have been hypothesis-based, potentially overlooking certain significant complications. This study conducts a comprehensive, non-hypothesis-based analysis of PE-complicated diagnoses after pregnancies using multiple large-scale electronic health records (EHR) datasets...
March 6, 2024: Research Square
https://read.qxmd.com/read/38496586/clinical-performance-of-cas13a-based-point-of-care-lateral-flow-assay-for-detecting-neisseria-gonorrhoeae
#22
Lao-Tzu Allan-Blitz, Gabriela Sanders, Palak Shah, Gordon Adams, Jana Jarolimova, Kevin Ard, John A Branda, Jeffrey D Klausner, Pardis C Sabeti, Jacob E Lemieux
BACKGROUND: Diagnosis of Neisseria (N.) gonorrhoeae is dependent on nucleic acid amplification testing (NAAT), which is not available in resource-limited settings where the prevalence of infection is highest. Recent advances in molecular diagnostics leveraging the high specificity of CRISPR enzymes can permit field-deployable, point-of-care lateral flow assays. We previously reported on the development and in vitro performance of a lateral flow assay for detecting N. gonorrhoeae . Here we aimed to pair that assay with point-of-care DNA extraction techniques and assess the performance on clinical urine specimens...
March 4, 2024: medRxiv
https://read.qxmd.com/read/38496469/uncovering-clinical-rehabilitation-technology-trends-field-observations-mixed-methods-analysis-and-data-visualization
#23
Courtney Celian, Hannah Redd, Kevin Smaller, Partha Ryali, James L Patton, David J Reinkensmeyer, Miriam R Rafferty
OBJECTIVE: To analyze real-world rehabilitation technology (RT) use, with a view toward enhancing RT development and adoption. DESIGN: A convergent, mixed-methods study using direct field observations, semi-structured templates, and summative content analysis. SETTING: Ten neurorehabilitation units in a single health system. PARTICIPANTS: 3 research clinicians (1OT, 2PTs) observed ∼60 OTs and 70 PTs in inpatient; ∼18 OTs and 30 PTs in outpatient...
March 7, 2024: medRxiv
https://read.qxmd.com/read/38496414/brain-orchestra-under-spontaneous-conditions-identifying-communication-modules-from-the-functional-architecture-of-area-v1
#24
Maria Papadopouli, Ioannis Smyrnakis, Emmanouil Koniotakis, Mario-Alexios Savaglio, Christina Brozi, Eleftheria Psilou, Ganna Palagina, Stelios Manolis Smirnakis
We used two-photon imaging to record from granular and supragranular layers in mouse primary visual cortex (V1) under spontaneous conditions and applied an extension of the spike time tiling coefficient (STTC; introduced by Cutts and Eglen) to map functional connectivity architecture within and across layers. We made several observations: Approximately, 19-34% of neuronal pairs within 300 µ m of each other exhibit statistically significant functional connections, compared to 10% at distances of 1mm or more...
March 4, 2024: bioRxiv
https://read.qxmd.com/read/38496362/disorienting-or-transforming-using-the-arts-and-humanities-to-foster-social-advocacy
#25
REVIEW
Snow Wangding, Lorelei Lingard, Paul Haidet, Benjamin Vipler, Javeed Sukhera, Tracy Moniz
INTRODUCTION: The arts and humanities (AH) have transformative potential in medical education. Research suggests that AH-based pedagogies may facilitate both personal and professional transformation in medical learners, which may then further enhance the teaching and learning of social advocacy skills. However, the potential for such curricula to advance social advocacy training remains under-explored. Therefore, we sought to identify how AH may facilitate transformative learning of social advocacy in medical education...
2024: Perspectives on Medical Education
https://read.qxmd.com/read/38496340/cost-effectiveness-of-one-health-intervention-to-reduce-risk-of-human-exposure-and-infection-with-non-typhoidal-salmonellosis-nts-in-nigeria
#26
JOURNAL ARTICLE
Abdullahi O Sanni, Annelize Jonker, Vincent Were, Olubunmi G Fasanmi, Oluwawemimo O Adebowale, Aminu Shittu, Abdurrahman H Jibril, Folorunso O Fasina
BACKGROUND: Non-typhoidal Salmonella infection (NTS) is an important foodborne zoonosis with underappreciated health and economic burdens, and low case fatality. It has global prevalence, with more burdens in under-resourced countries with poor health infrastructures. Using a cohort study, we determined the cost-effectiveness of NTS in humans in Nigeria for the year 2020. METHODS: Using a customized Excel-based cost-effectiveness analysis tool, structured (One Health) and unstructured (episodic intervention against NTS) in Nigeria were evaluated...
June 2024: One Health
https://read.qxmd.com/read/38496334/identifying-risk-factors-for-preexisting-or-developing-low-back-pain-in-youth-high-school-and-collegiate-lacrosse-players-using-3-dimensional-motion-analysis
#27
JOURNAL ARTICLE
Joseph G Wasser, Michelle L Bruner, Cong Chen, Heather K Vincent
BACKGROUND: Low back pain (LBP) is a common condition that can affect athletes of all ages. The risk factors for LBP onset and worsening associated with the lacrosse shooting motion are not yet known. PURPOSE: To identify training and biomechanical factors associated with preexisting LBP and development of LBP over 6 months in youth, high school, and collegiate lacrosse players. STUDY DESIGN: Case-control study; Level of evidence, 3. METHODS: A total of 128 lacrosse players were enrolled in this study between January 2016 and January 2019...
March 2024: Orthopaedic Journal of Sports Medicine
https://read.qxmd.com/read/38496252/wonder-symphony-epigenetics-and-the-enchantment-of-the-arts
#28
REVIEW
Marta Gallazzi, Marta Pizzolante, Elia Mario Biganzoli, Valentina Bollati
Epigenetics, the study of heritable changes in gene expression without altering the DNA sequence, has gained significant attention due to its implications for gene regulation and chromatin stability. Epigenetic mechanisms play a fundamental role in gene-environment interactions, shaping individual development and adaptation. DNA methylation, histone modifications, and non-coding RNAs are key epigenetic regulators. Epigenetic changes can be triggered by environmental factors, including stress, toxins, and social interactions, influencing health and well-being...
2024: Environmental Epigenetics
https://read.qxmd.com/read/38496158/high-diagnostic-accuracy-of-thyroid-stimulating-hormone-tsh-receptor-antibodies-in-distinguishing-graves-disease-and-subacute-thyrotoxicosis-in-the-indian-population
#29
JOURNAL ARTICLE
Lakshmi T Naga Nitin, Shilpa Lakkundi, Sagar Reddy S L, Dhananjaya M Shanthaiah, Sumanas G Datta, Umalakhmi Annavarapu, Vijaya Sarathi
BACKGROUND AND OBJECTIVE: Thyrotoxicosis is a common clinical condition encountered in endocrine practice. Graves' disease and subacute thyroiditis are the two common causes of thyrotoxicosis and often have overlapping clinical and biochemical features. 99mTc thyroid scintigraphy is the most commonly used confirmatory test to differentiate the two conditions but is not available in the majority of the second-tier cities of India. However, obtaining thyroid stimulating hormone (TSH) receptor antibodies (TSHrAb), another accurate test to differentiate the two conditions, in second-tier cities by outsourcing to labs in major cities is a feasible option nowadays...
February 2024: Curēus
https://read.qxmd.com/read/38496125/effects-of-the-covid-19-pandemic-on-breastfeeding-initiation-and-duration-a-retrospective-cohort-study
#30
JOURNAL ARTICLE
Mariana M Meneses, Catarina Freitas, Joana Machado Morais, Maria S Dias, Cláudia Ferraz, Sara Peixoto
INTRODUCTION AND OBJECTIVES: Several studies support the health benefits of breastfeeding for both the mother and the newborn. However, a significant number of mothers discontinue breastfeeding within the first six months of childbirth, with several factors influencing breastfeeding adherence. The purpose of this study is to assess the impact of the COVID-19 pandemic on the prevention of mother-to-newborn infection transmission, breastfeeding patterns and duration, and the incidence of other infections during the first year of life...
February 2024: Curēus
https://read.qxmd.com/read/38495995/study-on-flame-retardancy-of-epdm-reinforced-by-ammonium-polyphosphate
#31
JOURNAL ARTICLE
Yifei Chen, Shengping Yi, Xilong Zhang, Dunfa Shi, Chao Liu, Puwen Rao, Chi Huang
Currently, the most widely used material for solid rocket motor (SRM) insulation is ethylene propylene diene monomer (EPDM) filled with flame-retardant and ablation-resistant fillers. Researchers have been working hard to find a flame-retardant filler that can simultaneously meet the complex requirements of mechanical strength, density, flame retardancy and ablative performance of the insulation layer. This requires research on the flame retardant properties of flame retardants in oxygen-poor environments. In this paper, ammonium polyphosphate (APP) is used as a flame retardant filler, which is filled into an EPDM premix (p-EPDM) containing fumed silica and aluminum hydroxide to prepare composite materials...
March 14, 2024: RSC Advances
https://read.qxmd.com/read/38495987/-stixis-scandens-leaf-extract-loading-zno-nanoparticles-for-porcine-epidemic-diarrhea-virus-pedv-treatment
#32
JOURNAL ARTICLE
Thi Thu Huong Le, Thi Tam Than, Thi Ngọc Ha Lai, Van Phan Le
Porcine epidemic diarrhea (PED) is one of the diseases that causes great losses for livestock farmers. Because vaccines against the disease are not very effective, there is a great demand for biological products with effective resistance to PED virus (PEDV). One of the most important trends today is the use of active ingredients from nature in animal husbandry. This study aimed to create an effective agent against PEDV from the extract of Stixis scandens , which has been shown to inhibit PEDV. The aqueous (denoted as TCN) and ethanolic extracts (denoted as TCC) of Stixis scandens leaves were first prepared and then qualitatively analyzed for their chemical compositions...
March 14, 2024: RSC Advances
https://read.qxmd.com/read/38495943/clinical-study-of-reoperation-for-acute-type-a-aortic-dissection
#33
JOURNAL ARTICLE
Yi Feng, Xian-Tao Ma, Xiao-Xue Zhang, Akilu Wajeehullahi, Zi-Jun Chen, Shi-Liang Li, Cai Cheng
OBJECTIVE: The initial operation for type A aortic dissection has limitations, and there may be a need for reoperation in cases such as giant pseudoaneurysm formation and reduced blood supply to the distal vessels. In this study, we collected case data of patients who underwent cardiac major vascular surgery at our hospital to analyze the effectiveness of reoperation treatment options for type A aortic dissection and to summarize our treatment experience. METHOD: Between June 2018 and December 2022, 62 patients with type A aortic dissection (TAAD) underwent reoperation after previous surgical treatment...
2024: Frontiers in Cardiovascular Medicine
https://read.qxmd.com/read/38495935/group-movement-in-entomopathogenic-nematodes-aggregation-levels-vary-based-on-context
#34
JOURNAL ARTICLE
Glen Stevens, Muhammad Usman, Sehrish Gulzar, Cassandra Stevens, Eleanor Pimentel, Hilal Erdogan, Paul Schliekelman, Fatma Kaplan, Hans Alborn, Waqas Wakil, David Shapiro-Ilan, Edwin E Lewis
Maintenance of an aggregated population structure implies within-species communication. In mixed-species environments, species-specific aggregations may reduce interspecific competition and promote coexistence. We studied whether movement and aggregation behavior of three entomopathogenic nematode species changed when isolated, as compared to mixed-species arenas. Movement and aggregation of Steinernema carpocapsae , S. feltiae and S. glaseri were assessed in sand. Each species demonstrated significant aggregation when alone...
March 2024: Journal of Nematology
https://read.qxmd.com/read/38495906/differential-change-in-alcohol-consumption-during-the-covid-19-pandemic-the-role-of-loneliness-socialization-and-mental-well-being
#35
JOURNAL ARTICLE
Mohamed S Mohamed, Gull Rukh, Sofia Vadlin, Susanne Olofsdotter, Cecilia Åslund, Helgi B Schiöth, Kent W Nilsson
INTRODUCTION: The COVID-19 pandemic led to a surge in mental health issues and psychological distress, disruption to work/studying conditions, and social isolation particularly among young adults. Changes in these factors are differentially associated with alcohol use. Moreover, the relationship between these factors are bidirectional and may have fluctuated throughout the different phases of the pandemic. However, studies focusing on young adults had conflicting results, short follow-up periods, and lacked comprehensive data to describe underlying mechanisms...
2024: Frontiers in Psychiatry
https://read.qxmd.com/read/38495847/city-composition-and-accessibility-statistics-in-and-around-paris
#36
JOURNAL ARTICLE
Marie-Olive Thaury, Simon Genet, Léopold Maurice, Paola Tubaro, Sarah J Berkemer
INTRODUCTION: Is Paris a 15-min city, where inhabitants can access essential amenities such as schools and shops with a 15-min walk or bike ride? The concept of a 15-min (more generally, X-minute) city was launched in the French capital and was part of the current mayor's plan in her latest re-election campaign. Yet, its fit with the existing urban structure had not been previously assessed. METHODS: This article combines open map data from a large participatory project and geo-localized socio-economic data from official statistics to fill this gap...
2024: Frontiers in big data
https://read.qxmd.com/read/38495792/differences-in-the-clinical-and-hormonal-presentation-of-patients-with-familial-and-sporadic-primary-aldosteronism
#37
JOURNAL ARTICLE
Marta Araujo-Castro, Paola Parra, Patricia Martín Rojas-Marcos, Miguel Paja Fano, Marga González Boillos, Eider Pascual-Corrales, Ana María García Cano, Jorge Gabriel Ruiz-Sanchez, Almudena Vicente Delgado, Emilia Gómez Hoyos, Rui Ferreira, Iñigo García Sanz, Mònica Recasens Sala, Rebeca Barahona San Millan, María José Picón César, Patricia Díaz Guardiola, Carolina M Perdomo, Laura Manjón-Miguélez, Rogelio García Centeno, Ángel Rebollo Román, Paola Gracia Gimeno, Cristina Robles Lázaro, Manuel Morales-Ruiz, María Calatayud, Simone Andree Furio Collao, Diego Meneses, Miguel Sampedro Nuñez, Verónica Escudero Quesada, Elena Mena Ribas, Alicia Sanmartín Sánchez, Cesar Gonzalvo Diaz, Cristina Lamas, María Del Castillo Tous, Joaquín Serrano Gotarredona, Theodora Michalopoulou Alevras, Eva María Moya Mateo, Felicia A Hanzu
PURPOSE: To compare the clinical and hormonal characteristics of patients with familial hyperaldosteronism (FH) and sporadic primary aldosteronism (PA). METHODS: A systematic review of the literature was performed for the identification of FH patients. The SPAIN-ALDO registry cohort of patients with no suspicion of FH was chosen as the comparator group (sporadic group). RESULTS: A total of 360 FH (246 FH type I, 73 type II, 29 type III, and 12 type IV) cases and 830 sporadic PA patients were included...
2024: Frontiers in Endocrinology
https://read.qxmd.com/read/38495706/rapid-and-accurate-identification-of-bacteria-utilizing-laser-induced-breakdown-spectroscopy
#38
JOURNAL ARTICLE
J H Liang, S Q Wang, W F Zhang, Y Guo, Y Zhang, F Chen, L Zhang, W B Yin, L T Xiao, S T Jia
Timely and accurate identification of harmful bacterial species in the environment is paramount for preventing the spread of diseases and ensuring food safety. In this study, laser-induced breakdown spectroscopy technology was utilized, combined with four machine learning methods - KNN, PCA-KNN, RF, and SVM, to conduct classification and identification research on 7 different types of bacteria, adhering to various substrate materials. The experimental results showed that despite the nearly identical elemental composition of these bacteria, differences in the intensity of elemental spectral lines provide crucial information for identification of bacteria...
March 1, 2024: Biomedical Optics Express
https://read.qxmd.com/read/38495614/small-group-conversations-in-a-pogil-based-class-how-english-learners-engage-in-a-joint-knowledge-construction-process-to-reach-a-shared-understanding
#39
JOURNAL ARTICLE
Shaghayegh Fateh, Oluwatobiloba Theresa Ayangbola, Joshua W Reid, Sylvia W Zakher, Zubeyde Demet Kirbulut Gunes, Amy J Phelps, Aspen Malone, Gregory T Rushton
Collaboration is an aspect of engagement that focuses on learning through group work and having discussions with other learners. Active learning approaches are a way to foster collaborative engagement because they provide more opportunities for interaction among learners. Process Oriented Guided Inquiry Learning (POGIL), a socially mediated active learning approach, uses verbalizing and discussing ideas with peers in small groups to reach a shared understanding. Due to the growing number of immigrants in the United States, the number of English Learners (ELs) in American classrooms has been increasing rapidly...
March 12, 2024: Journal of Chemical Education
https://read.qxmd.com/read/38495580/outcomes-of-operatively-managed-periprosthetic-distal-femur-fractures-compared-to-fractures-in-patients-with-native-knees
#40
JOURNAL ARTICLE
Nicholas Bostrom, Thomas Z Paull, Mai P Nguyen
INTRODUCTION: With the increasing incidence of total knee arthroplasty (TKA), there is an expected rise in rate of periprosthetic fractures in the coming years. It is unclear how the outcomes of patients with distal femur fractures (DFF) and a total knee arthroplasty compare to patients of the same age group with native knees (NK). MATERIALS AND METHODS: A retrospective review was completed for distal femur fractures treated with surgical fixation from January 2019-March 2021...
July 2024: Journal of Orthopaedics
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