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https://www.readbyqxmd.com/read/28449560/assessment-of-the-latent-adverse-events-of-antipsychotic-treatment-using-a-subjective-questionnaire-in-japanese-patients-with-schizophrenia
#1
Masakazu Hatano, Hiroyuki Kamei, Azusa Kato, Ippei Takeuchi, Manako Hanya, Junji Uno, Shigeki Yamada, Kiyoshi Fujita, Nakao Iwata
Objective: The adverse effects of antipsychotic agents can have a marked influence on medication adherence. In this study, we. investigated the adverse events of antipsychotics that are less likely to be reported by patients and the reasons why such symptoms remain latent. Methods: Data were collected by interviewing patients using a subjective questionnaire, and the associations between unreported symptoms and background factors were investigated. Results: A total of 306 patients with schizophrenia or schizoaffective disorder were examined...
May 31, 2017: Clinical Psychopharmacology and Neuroscience: the Official Scientific Journal of the Korean College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28449474/impact-of-lymph-node-management-on-resectable-non-small-cell-lung-cancer-patients
#2
Apichat Tantraworasin, Somcharoen Saeteng, Sophon Siwachat, Tawatchai Jiarawasupornchai, Nirush Lertprasertsuke, Sarawut Kongkarnka, Chidchanok Ruengorn, Jayanton Patumanond, Emanuela Taioli, Raja M Flores
BACKGROUND: A surgical lung resection with systematic mediastinal lymph node (LN) dissection is recommended by the National Comprehensive Cancer Network guideline. However, the effective number of dissected LNs, stations and positivity is still controversial. The aim of this study is to identify the impact of total numbers, LN stations and positivity of dissected LNs on tumor recurrence and overall death in resectable non-small cell lung cancer (NSCLC). METHODS: This prognostic study used a retrospective data collection design...
March 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28449323/in-vitro-comparison-of-renal-stone-laser-treatment-using-fragmentation-and-popcorn-technique
#3
Paul Klaver, Tjeerd de Boorder, Alex I Rem, Tycho M T W Lock, Herke Jan Noordmans
OBJECTIVE: To study the effectiveness of two laser techniques clinically used to fragment renal stones: fragmenting technique (FT) and popcorn technique (PT). METHODS: Phantom stones were placed in a test tube filled with water, mimicking a renal calyx model. A Holmium:YAG laser was used for fragmentation using both techniques. Four series of experiments were performed with two parameters: the technique (FT or PT) and the number of stones in the test tube (one or four)...
April 27, 2017: Lasers in Surgery and Medicine
https://www.readbyqxmd.com/read/28449229/exposure-to-texture-of-foods-for-8-month-old-infants-does-the-size-of-the-pieces-matter
#4
Saakje P da Costa, Lianne Remijn, Hugo Weenen, Carel Vereijken, Cees van der Schans
The present study examined the effect of meals varying in amount, size, and hardness of food pieces on the development of the chewing capabilities of 8-month-old infants. The study also examined changes in shivering, gagging, coughing, choking, and their ability to eat from a spoon. In an in-home setting two groups were given commercially available infant meals and fruits, purees with either less, smaller and softer or more, larger and harder pieces. Both groups were given these foods for 4 weeks and were monitored several times during this period...
April 27, 2017: Journal of Texture Studies
https://www.readbyqxmd.com/read/28449202/barn-owls-maximize-head-rotations-by-a-combination-of-yawing-and-rolling-in-functionally-diverse-regions-of-the-neck
#5
Markus Krings, John A Nyakatura, Mark L L M Boumans, Martin S Fischer, Hermann Wagner
Owls are known for their outstanding neck mobility: these birds can rotate their heads more than 270°. The anatomical basis of this extraordinary neck rotation ability is not well understood. We used X-ray fluoroscopy of living owls as well as forced neck rotations in dead specimens and computer tomographic (CT) reconstructions to study how the individual cervical joints contribute to head rotation in barn owls (Tyto furcata pratincola). The X-ray data showed the natural posture of the neck, and the reconstructions of the CT-scans provided the shapes of the individual vertebrae...
April 27, 2017: Journal of Anatomy
https://www.readbyqxmd.com/read/28449128/comprehensive-ryan-white-assistance-and-hiv-clinical-outcomes-retention-in-care-and-viral-suppression-in-a-medicaid-non-expansion-state
#6
Karen L Diepstra, Anne G Rhodes, Rose S Bono, Sonam Patel, Lauren E Yerkes, April D Kimmel
Background: Knowledge gaps remain about how the Ryan White HIV/AIDS Program (RW) contributes to health outcomes. We examined the association between different RW service classes and retention in care (RiC) or viral suppression (VS). Methods: We identified Virginians engaged in any HIV care, January 1-December 31, 2014. RW beneficiaries were classified by receipt of ≥1 service from three classes: Core medical, Support and insurance and/or direct medication assistance through the AIDS Drug Assistance Program (ADAP)...
April 25, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28448844/consequences-of-bioenergy-wood-extraction-for-landscape-level-availability-of-habitat-for-dead-wood-dependent-organisms
#7
Matthew Hiron, Mats Jonsell, Ariana Kubart, Göran Thor, Martin Schroeder, Anders Dahlberg, Victor Johansson, Thomas Ranius
Stumps and slash resulting from forest clearcutting is used as a source of low-net-carbon energy, but there are concerns about the consequences of biofuel extraction on biodiversity. Logging residues constitute potentially important habitats, since a large part of forest biodiversity is dependent on dead wood. Here we used snapshot field data from a managed forest landscape (25 000 ha) to predict landscape scale population changes of dead wood dependent organisms after extraction of stumps and slash after clearcutting...
April 24, 2017: Journal of Environmental Management
https://www.readbyqxmd.com/read/28448801/the-placental-factor-in-spontaneous-preterm-birth-in-twin-vs-singleton-pregnancies
#8
Eran Weiner, Ann Dekalo, Ohad Feldstein, Elad Barber, Letizia Schreiber, Jacob Bar, Michal Kovo
OBJECTIVE: The association between infection and inflammatory response in singleton preterm birth (PTB) is well established, yet, less is known about PTB in twins. We aimed to compare the placental component and pregnancy outcome in pregnancies complicated with PTB of singletons vs. twin deliveries. We hypothesized that due to different underlying mechanisms, placental inflammatory lesions will be more prevalent in placentas derived from singleton pregnancies than twins. STUDY DESIGN: Labor characteristics, neonatal outcome and placental histopathology reports of spontaneous PTB at 24-33(6)/7 weeks, from 1/2008-12/2015, were reviewed...
April 22, 2017: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/28448784/a-motivational-interviewing-intervention-by-pharmacy-students-to-improve-medication-adherence
#9
Susan Abughosh, Xin Wang, Omar Serna, Tara Esse, Amanda Mann, Santhi Masilamani, Marcia McDonnell Holstad, Ekere James Essien, Marc Fleming
BACKGROUND: Diabetes mellitus (DM) patients with comorbid hypertension (HTN) are at a higher risk of developing microvascular and macrovascular DM complications. Through guideline-driven recommendations, angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin II receptor blockers (ARBs) are highly recommended for these patients. Unfortunately, medication adherence to these products, though crucial to achieving therapeutic benefit, is frequently suboptimal. Motivational interviewing (MI) is a patient-centered collaborative communication style that is used to strengthen internal motivation for change that may prove effective in enhancing adherence...
May 2017: Journal of Managed Care & Specialty Pharmacy
https://www.readbyqxmd.com/read/28448754/clinical-evaluation-of-cost-efficacy-of-drugs-for-treatment-of-osteoporosis-a-meta-analysis
#10
Stewart G Albert, Supraja Reddy
OBJECTIVE: To assess the cost efficacy of available regimens for therapy of osteoporosis as defined as the cost time's number need to treat to prevent one fracture. PATIENTS AND METHODS: Existing meta-analyses were supplemented through electronic databases SCOPUS and PubMED between 2013 (a date overlapping the latest meta-analyses) and March 2016. Primary references included all randomized controlled trials of anti-osteoporotic drugs versus comparators using search terms "osteoporosis", "random" and "trial"...
April 27, 2017: Endocrine Practice
https://www.readbyqxmd.com/read/28448669/prevalence-of-undiagnosed-age-related-macular-degeneration-in-primary-eye-care
#11
David C Neely, Kevin J Bray, Carrie E Huisingh, Mark E Clark, Gerald McGwin, Cynthia Owsley
Importance: Age-related macular degeneration (AMD) is the leading cause of irreversible vision impairment in older adults in the United States, yet little is known about whether AMD is appropriately diagnosed in primary eye care. Objectives: To examine the prevalence of eyes with AMD in patients seen in primary eye care clinics who purportedly have normal macular health per their medical record and the association of AMD with patient and physician characteristics...
April 27, 2017: JAMA Ophthalmology
https://www.readbyqxmd.com/read/28448655/change-in-diabetic-retinopathy-through-2-years-secondary-analysis-of-a-randomized-clinical-trial-comparing-aflibercept-bevacizumab-and-ranibizumab
#12
Susan B Bressler, Danni Liu, Adam R Glassman, Barbara A Blodi, Alessandro A Castellarin, Lee M Jampol, Paul L Kaufman, Michele Melia, Harinderjit Singh, John A Wells
Importance: Anti-vascular endothelial growth factor (anti-VEGF) therapy for diabetic macular edema (DME) favorably affects diabetic retinopathy (DR) improvement and worsening. It is unknown whether these effects differ across anti-VEGF agents. Objective: To compare changes in DR severity during aflibercept, bevacizumab, or ranibizumab treatment for DME. Design, Setting, and Participants: Preplanned secondary analysis of data from a comparative effectiveness trial for center-involved DME was conducted in 650 participants receiving aflibercept, bevacizumab, or ranibizumab...
April 27, 2017: JAMA Ophthalmology
https://www.readbyqxmd.com/read/28448590/significant-changes-in-circulating-microrna-by-dietary-supplementation-of-selenium-and-coenzyme-q10-in-healthy-elderly-males-a-subgroup-analysis-of-a-prospective-randomized-double-blind-placebo-controlled-trial-among-elderly-swedish-citizens
#13
Urban Alehagen, Peter Johansson, Jan Aaseth, Jan Alexander, Dick Wågsäter
BACKGROUND: Selenium and coenzyme Q10 is essential for important cellular functions. A low selenium intake is reported from many European countries, and the endogenous coenzyme Q10 production is decreasing in the body with increasing age. Supplementation with selenium and coenzyme Q10 in elderly have shown reduced cardiovascular mortality and reduced levels of markers of inflammation. However, microRNA analyses could give important information on the mechanisms behind the clinical effects of supplementation...
2017: PloS One
https://www.readbyqxmd.com/read/28448589/morpho-physiological-analysis-of-tolerance-to-aluminum-toxicity-in-rice-varieties-of-north-east-india
#14
Jay Prakash Awasthi, Bedabrata Saha, Preetom Regon, Smita Sahoo, Umakanta Chowra, Amit Pradhan, Anupam Roy, Sanjib Kumar Panda
Aluminum (Al) is the third most abundant metal in earth crust, whose chemical form is mainly dependent on soil pH. The most toxic form of Al with respect to plants is Al3+, which exists in soil pH <5. Acidic soil significantly limits crop production mainly due to Al3+ toxicity worldwide, impacting approximately 50% of the world's arable land (in North-Eastern India 80% soil are acidic). Al3+ toxicity in plants ensues root growth inhibition leading to less nutrient and water uptake impacting crop productivity as a whole...
2017: PloS One
https://www.readbyqxmd.com/read/28448528/minimally-invasive-estimation-of-ventricular-dead-space-volume-through-use-of-frank-starling-curves
#15
Shaun Davidson, Chris Pretty, Antoine Pironet, Thomas Desaive, Nathalie Janssen, Bernard Lambermont, Philippe Morimont, J Geoffrey Chase
This paper develops a means of more easily and less invasively estimating ventricular dead space volume (Vd), an important, but difficult to measure physiological parameter. Vd represents a subject and condition dependent portion of measured ventricular volume that is not actively participating in ventricular function. It is employed in models based on the time varying elastance concept, which see widespread use in haemodynamic studies, and may have direct diagnostic use. The proposed method involves linear extrapolation of a Frank-Starling curve (stroke volume vs end-diastolic volume) and its end-systolic equivalent (stroke volume vs end-systolic volume), developed across normal clinical procedures such as recruitment manoeuvres, to their point of intersection with the y-axis (where stroke volume is 0) to determine Vd...
2017: PloS One
https://www.readbyqxmd.com/read/28448466/multiplexed-electrochemical-immunosensors-for-clinical-biomarkers
#16
REVIEW
Paloma Yáñez-Sedeño, Susana Campuzano, José M Pingarrón
Management and prognosis of disease requires the accurate determination of specific biomarkers indicative of normal or disease-related biological processes or responses to therapy. Moreover since multiple determinations of biomarkers have demonstrated to provide more accurate information than individual determinations to assist the clinician in prognosis and diagnosis, the detection of several clinical biomarkers by using the same analytical device hold enormous potential for early detection and personalized therapy and will simplify the diagnosis providing more information in less time...
April 27, 2017: Sensors
https://www.readbyqxmd.com/read/28448266/a-prospective-randomized-blinded-controlled-trial-comparing-transdermal-continuous-oxygen-delivery-to-moist-wound-therapy-for-the-treatment-of-diabetic-foot-ulcers
#17
Vickie R Driver, Alexander Reyzelman, Jill Kawalec, Michael French
Worldwide, diabetic foot ulcers (DFUs) continue to exact a major burden on patients and health care providers. Although hyperbaric oxygen therapy is well-known as an adjunct option, less is known about the efficacy of transdermal continuous oxygen therapy (TCOT). A prospective, randomized, blinded, multicenter, parallel study was conducted from October 2009 to November 2012 to evaluate healing time and the proportion of DFUs healed after 12 weeks of moist wound therapy (MWT) with or without TCOT. Study participants (persons with type 1 or type 2 diabetes and a nonhealing [>1-month but <1-year duration], 1 cm² to 10 cm² in area, infection-free DFU) were randomized to TCOT or a sham device (control) in addition to receiving MWT...
April 2017: Ostomy/wound Management
https://www.readbyqxmd.com/read/28448177/once-weekly-dipeptidyl-peptidase-4-inhibitors-for-type-2-diabetes-a-systematic-review-and-meta-analysis
#18
Dimitrios Stoimenis, Thomas Karagiannis, Anastasia Katsoula, Eleni Athanasiadou, Kyriakos Kazakos, Eleni Bekiari, David R Matthews, Apostolos Tsapas
OBJECTIVE: To assess the efficacy and safety of omarigliptin and trelagliptin, novel dipeptidyl peptidase-4 inhibitors administered once-weekly (DPP-4i QW). METHODS: We systematically searched for placebo- and active-controlled randomized trials in adults with type 2 diabetes mellitus. RESULTS: Fifteen primary studies with 5709 participants were included. DPP-4i QW were more effective than placebo in reducing hemoglobin A1c (HbA1c) (Weighted Mean Difference (WMD) -0...
April 27, 2017: Expert Opinion on Pharmacotherapy
https://www.readbyqxmd.com/read/28448138/idp-specific-force-field-ff14idpsff-improves-the-conformer-sampling-of-intrinsically-disordered-proteins
#19
Dong Song, Ray Luo, Hai-Feng Chen
Intrinsically disordered proteins (IDPs) or intrinsically disordered regions have not fixed tertiary structure, but play key roles in signal regulation, molecule recognition, and drug target. However it is difficult to study the structure and function of IDPs by traditional experimental methods because of their diverse conformations. Limitations of current generic protein force fields and solvent models were reported in the previous simulations of IDPs. We have also explored to overcome these limitations by developing ff99IDPs and ff14IDPs force fields to correct the dihedral distribution for eight disordered promoting residues often observed in IDPs and found encouraging improvements...
April 27, 2017: Journal of Chemical Information and Modeling
https://www.readbyqxmd.com/read/28448111/stepwise-deprotonation-of-magnetite-supported-gallic-acid-modulates-oxidation-state-and-adsorption-assisted-translocation-of-hexavalent-chromium
#20
Xiaoyu Guan, Yi Chen, Haojun Fan
Recently, a synergistic strategy involving reduction of carcinogenic Cr(VI) into less toxic Cr(III) followed by Cr(III) adsorption and subsequent separation by surface-engineered magnetite nanoparticles has emerged as a promising alternative to address the environmental hazards associated with Cr(VI)-contaminated water. Despite several previous attempts exploiting this synergy, modulating the oxidation state and translocation of Cr(VI) with high spatiotemporal precision remains a major challenge. Here, we report how Cr(VI) responds accordingly in a well-defined manner to deprotonation of gallic acid covalently immobilized on magnetite nanoparticles, which proceeds through a fixed spatial sequence of distinct stages...
April 27, 2017: ACS Applied Materials & Interfaces
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