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https://www.readbyqxmd.com/read/28429788/the-hsp90-chaperone-machinery
#1
REVIEW
Florian H Schopf, Maximilian M Biebl, Johannes Buchner
The heat shock protein 90 (HSP90) chaperone machinery is a key regulator of proteostasis under both physiological and stress conditions in eukaryotic cells. As HSP90 has several hundred protein substrates (or 'clients'), it is involved in many cellular processes beyond protein folding, which include DNA repair, development, the immune response and neurodegenerative disease. A large number of co-chaperones interact with HSP90 and regulate the ATPase-associated conformational changes of the HSP90 dimer that occur during the processing of clients...
April 21, 2017: Nature Reviews. Molecular Cell Biology
https://www.readbyqxmd.com/read/28429153/relative-abundance-of-heat-shock-proteins-and-clusterin-transcripts-in-spermatozoa-collected-form-boar-routinely-utilised-in-an-artificial-insemination-centre-preliminary-results
#2
A Zannoni, C Bernardini, A Zaniboni, E Ferlizza, D Ventrella, M L Bacci, M Forni
It is widely accepted that mature sperm contains RNA. The first hypothesis was that sperm RNAs have no functions of their own but are simply residues of spermatogenesis reflecting the events that occurred during their formation in the testes. More recently new discoveries have essentially expanded these views, showing that sperm mRNAs constitute a population of stable full-length transcripts, many of which are selectively retained during spermatogenesis and delivered to oocytes contributing to early embryo development...
April 21, 2017: Veterinary Research Communications
https://www.readbyqxmd.com/read/28426997/design-and-synthesis-of-neolamellarin-a-derivatives-targeting-heat-shock-protein-90
#3
Long Jiang, Ruijuan Yin, Xueting Wang, Jiajia Dai, Jing Li, Tao Jiang, Rilei Yu
In this study, we designed and synthesized a novel family of neolamellarin A derivatives that showed high inhibitory activity toward heat shock protein 90 (Hsp90), a kinase associated with cell proliferation. The 3,4-bis(catechol)pyrrole scaffold and the benzyl group with methoxy modification at N position of pyrrole are essential to the Hsp90 inhibitory activity and cytotoxicity of these compounds. Western blot analysis demonstrated that these compounds induced dramatic depletion of the examined client proteins of Hsp90, and accelerated cancer cell apoptosis...
April 15, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28426278/hop3-a-new-regulator-of-the-er-stress-response-in-arabidopsis-with-possible-implications-in-plant-development-and-response-to-biotic-and-abiotic-stresses
#4
Nuria Fernández-Bautista, Lourdes Fernández-Calvino, Alfonso Muñoz, M Mar Castellano
HOPs (heat shock protein 70 (HSP70)-heat shock protein 90 (HSP90) organizing proteins) are a highly conserved family of cytosolic cochaperones. In a recent study we showed that HOP3, one member of the HOP family in Arabidopsis, plays an essential role during endoplasmic reticulum (ER) stress in plants. Interestingly, we also demonstrated that AtHOP3 interacts with binding immunoglobulin protein (BiP), a major ER-resident chaperone. All these data suggest that HOP3 could assist BiP in protein folding in the ER...
April 20, 2017: Plant Signaling & Behavior
https://www.readbyqxmd.com/read/28424411/migration-pattern-actin-cytoskeleton-organization-and-response-to-pi3k-mtor-and-hsp90-inhibition-of-glioblastoma-cells-with-different-invasive-capacities
#5
Simon Memmel, Dmitri Sisario, Caren Zöller, Vanessa Fiedler, Astrid Katzer, Robin Heiden, Nicholas Becker, Lorenz Eing, Fábio L R Ferreira, Heiko Zimmermann, Markus Sauer, Michael Flentje, Vladimir L Sukhorukov, Cholpon S Djuzenova
High invasiveness and resistance to chemo- and radiotherapy of glioblastoma multiforme (GBM) make it the most lethal brain tumor. Therefore, new treatment strategies for preventing migration and invasion of GBM cells are needed. Using two different migration assays, Western blotting, conventional and super-resolution (dSTORM) fluorescence microscopy we examine the effects of the dual PI3K/mTOR-inhibitor PI-103 alone and in combination with the Hsp90 inhibitor NVP-AUY922 and/or irradiation on the migration, expression of marker proteins, focal adhesions and F-actin cytoskeleton in two GBM cell lines (DK-MG and SNB19) markedly differing in their invasive capacity...
April 5, 2017: Oncotarget
https://www.readbyqxmd.com/read/28423555/hsp90-proteins-in-the-scenario-of-tumor-complexity
#6
Andrea Rasola
No abstract text is available yet for this article.
March 28, 2017: Oncotarget
https://www.readbyqxmd.com/read/28419378/arsenic-induced-testicular-toxicity-in-gallus-gallus-expressions-of-inflammatory-cytokines-and-heat-shock-proteins
#7
Xiao Sun, Siwen Li, Ying He, Hongjing Zhao, Yu Wang, Xiangwei Zeng, Mingwei Xing
The aim of the study is to investigate the effects of sub-chronic poisoning with arsenic on the testes of chickens treated. Seventy-two 1-day-old chickens were randomly divided into 4 groups and provided food with different doses arsenic. The histological changes were examined. The mRNA levels of inflammatory factors, including transcription factor nuclear factor-κB (NF-κB), tumor necrosis factor-α (TNF-α), inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), prostaglandin E synthase (PTGEs), and heat shock proteins (Hsps), including Hsp70, Hsp90, Hsp60, Hsp40, and Hsp27 were assessed by quantitative real-time PCR in the testes of chickens...
April 17, 2017: Poultry Science
https://www.readbyqxmd.com/read/28419216/lav-bpifb4-isoform-modulates-enos-signaling-through-ca2-pkc-alpha-dependent-mechanism
#8
Chiara Carmela Spinelli, Albino Carrizzo, Anna Ferrario, Francesco Villa, Antonio Damato, Mariateresa Ambrosio, Michele Madonna, Giacomo Frati, Sergio Fucile, Miriam Sciaccalunga, Mario Capunzo, Gaetano Calì, Luciano Milanesi, Anna Maciag, Annibale Alessandro Puca, Carmine Vecchione
Aims: Aging is associated with impairment of endothelial nitric oxide synthase (eNOS) and progressive reduction in endothelial function. A genetic study on long-living individuals - who are characterized by delays in aging and in the onset of cardiovascular disease - previously revealed I229V ( rs2070325 ) in BPIFB4 as a longevity-associated variant (LAV); the LAV protein enhanced endothelial NO production and vasorelaxation through a PERK/14-3-3/HSP90 signal. Here, we further characterize the molecular mechanisms underlying LAV-BPIFB4-dependent enhancement of vascular function...
April 13, 2017: Cardiovascular Research
https://www.readbyqxmd.com/read/28415650/a-highly-conserved-redox-active-mx-2-cwx-6-r-motif-regulates-zap70-stability-and-activity
#9
Christoph Thurm, Mateusz P Poltorak, Elisa Reimer, Melanie M Brinkmann, Lars Leichert, Burkhart Schraven, Luca Simeoni
ζ-associated protein of 70 kDa (Zap70) is crucial for T-cell receptor (TCR) signaling. Loss of Zap70 in both humans and mice results in severe immunodeficiency. On the other hand, the expression of Zap70 in B-cell malignancies correlates with the severity of the disease. Because of its role in immune-related disorders, Zap70 has become a therapeutic target for the treatment of human diseases. It is well-established that the activity/expression of Zap70 is regulated by post-translational modifications of crucial amino acids including the phosphorylation of tyrosines and the ubiquitination of lysines...
March 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/28414930/antipsychotics-promote-gabaergic-interneuron-genesis-in-the-adult-rat-brain-role-of-heat-shock-protein-production
#10
Hiroo Kaneta, Wataru Ukai, Hanako Tsujino, Kengo Furuse, Yoshiyasu Kigawa, Masaya Tayama, Takao Ishii, Eri Hashimoto, Chiaki Kawanishi
Current antipsychotics reduce positive symptoms and reverse negative symptoms in conjunction with cognitive behavioral issues with the goal of restoring impaired occupational and social functioning. However, limited information is available on their influence on gliogenesis or their neurogenic properties in adult schizophrenia brains, particularly on GABAergic interneuron production. In the present study, we used young adult subventricular zone (SVZ)-derived progenitor cells expressing proteoglycan NG2 cultures to examine the oligodendrocyte and GABAergic interneuron genesis effects of several kinds of antipsychotics on changes in differentiation function induced by exposure to the NMDA receptor antagonist MK-801...
March 10, 2017: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/28412732/small-molecule-inhibitor-screening-identifified-hsp90-inhibitor-17-aag-as-potential-therapeutic-agent-for-gallbladder-cancer
#11
Helga Weber, José R Valbuena, Mustafa A Barbhuiya, Stefan Stein, Hana Kunkel, Patricia García, Carolina Bizama, Ismael Riquelme, Jaime A Espinoza, Stephen E Kurtz, Jeffrey W Tyner, Juan Francisco Calderon, Alejandro H Corvalán, Manuel Grez, Akhilesh Pandey, Pamela Leal-Rojas, Juan C Roa
Gallbladder cancer (GBC) is a lethal cancer with poor prognosis associated with high invasiveness and poor response to chemotherapy and radiotherapy. New therapeutic approaches are urgently needed in order to improve survival and response rates of GBC patients. We screened 130 small molecule inhibitors on a panel of seven GBC cell lines and identified the HSP90 inhibitor 17-AAG as one of the most potent inhibitory drugs across the different lines. We tested the antitumor efficacy of 17-AAG and geldanamycin (GA) in vitro and in a subcutaneous preclinical tumor model NOD-SCID mice...
February 16, 2017: Oncotarget
https://www.readbyqxmd.com/read/28412368/hsp90-inhibitor-nvp-auy922-induces-cell-apoptosis-by-disruption-of-the-survivin-in-papillary-thyroid-carcinoma-cells
#12
Jinhao Liu, Wei Sun, Wenwu Dong, Zhihong Wang, Yuan Qin, Ting Zhang, Hao Zhang
Heat shock protein 90 (HSP90) is a molecular chaperone required for maintaining the stability and function of signal proteins that plays an important role in promoting the growth and survival of cancer cells. The incidence of papillary thyroid carcinoma (PTC) has been increasing in recent years. The effect of the novel non-geldanamycin HSP90 inhibitor NVP-AUY922 on apoptosis of papillary thyroid carcinoma cells has not been investigated. The influence of AUY922 on the survival of PTC cell lines K1 and IHH4 was evaluated...
April 12, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28410577/a-candidate-rxlr-effector-from-plasmopara-viticola-can-elicit-immune-responses-in-nicotiana-benthamiana
#13
Jiang Xiang, Xinlong Li, Ling Yin, Yunxiao Liu, Yali Zhang, Junjie Qu, Jiang Lu
BACKGROUND: Diverse plant pathogens deliver effectors into plant cells to alter host processes. Oomycete pathogen encodes a large number of putative RxLR effectors which are likely to play a role in manipulating plant defense responses. The secretome of Plasmopara viticola (downy mildew of grapevine) contains at least 162 candidate RxLR effectors discovered in our recent studies, but their roles in infection and pathogenicity remain to be determined. Here, we characterize in depth one of the putative RxLR effectors, PvRxLR16, which has been reported to induce cell death in Nicotiana benthamiana in our previous study...
April 14, 2017: BMC Plant Biology
https://www.readbyqxmd.com/read/28410515/folate-receptor-targeted-hybrid-lipid-core-nanocapsules-for-sequential-delivery-of-doxorubicin-and-tanespimycin
#14
Biki Gupta, Shiva Pathak, Bijay Kumar Poudel, Shobha Regmi, Hima Bindu Ruttala, Milan Gautam, Jong Seong Lee, Jee-Heon Jeong, Han-Gon Choi, Chul Soon Yong, Jong Oh Kim
When exposed to cancer cells, cytotoxic drugs such as doxorubicin (DOX) can lead to the induction of heat shock protein 90 (Hsp90), a molecular chaperone associated with a number of cancer-related client proteins, and result in cell survival. Co-administration of DOX with tanespimycin (TNP), an Hsp90 inhibitor, can sensitize the cancer cells to the cytotoxic effects of DOX. The effect of such a combination has been found to depend on the schedule of administration. Sequential administration of DOX and TNP has been linked to highly synergistic combination effects...
April 6, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28409385/the-effect-of-dietary-folic-acid-on-biochemical-parameters-and-gene-expression-of-three-heat-shock-proteins-hsps-of-blunt-snout-bream-megalobrama-amblycephala-fingerling-under-acute-high-temperature-stress
#15
Daniella Fatmata Sesay, Habte-Michael Habte-Tsion, Qunlan Zhou, Mingchun Ren, Jun Xie, Bo Liu, Ruli Chen, Liangkun Pan
The effects of dietary folic acid on biochemical parameters and gene expression of three heat shock proteins (HSPs) of blunt snout bream (Megalobrama amblycephala) fingerling under acute high temperature stress. Six dietary folic acid groups (0.0, 0.5, 1.0, 2.0, 5.0, and 10.0) mg/kg diets were designed and assigned into 18 tanks in three replicates each (300 l/tank) and were administered for 10 weeks in a re-circulated water system. The fingerlings with an initial weight of 27.0 ± 0.03 g were fed with their respective diets four times daily...
April 13, 2017: Fish Physiology and Biochemistry
https://www.readbyqxmd.com/read/28408431/molecular-basis-for-the-interaction-between-stress-inducible-phosphoprotein-1-stip1-and-s100a1
#16
Andrzej Maciejewski, Vania F Prado, Marco A M Prado, Wing-Yiu Choy
Stress-inducible phosphoprotein 1 (STIP1) is a cellular co-chaperone, which regulates Hsp70 and Hsp90 activity during client protein folding. Members of the S100-family of dimeric calcium binding proteins have been found to inhibit Hsp association with STIP1 through binding of STIP1 tetratricopeptide repeat (TPR) domains, possibly regulating the chaperone cycle. Here we investigated the molecular basis of S100A1 binding to STIP1. We show that three S100A1 dimers associate with one molecule of STIP1 in a calcium-dependent manner...
April 13, 2017: Biochemical Journal
https://www.readbyqxmd.com/read/28408351/inhibition-of-heat-shock-protein-90-rescues-glucocorticoid-induced-bone-loss-through-enhancing-bone-formation
#17
Haixiao Chen, Ji Xing, Xinhua Hu, Lihua Chen, Haiyan Lv, Chengyun Xu, Dun Hong, Ximei Wu
Endogenous glucocorticoids (GCs) support normal bone development and bone mass maintenance, whereas long-term exposure to pharmacological dosages of GCs uncouples bone formation and resorption, resulting in GC-induced osteoporosis (GIOP). Heat shock protein 90 (HSP90) chaperoning glucocorticoid receptor (GR) signaling prompts us to speculate that HSP90 plays critical roles in GC-mediated bone formation and GIOP. In the present study, inhibition of HSP90 activity by 17-Demethoxy-17-allyaminogeldanmycin (17-AAG) or knockdown of HSP90 expression by siRNAs attenuated dexamethasone(Dex)-induced GR nuclear accumulation and transcriptional output of GR signaling, whereas overexpression of HSP90α or HSP90β enhanced GR transactivity in C3H10T1/2 cells...
April 10, 2017: Journal of Steroid Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/28407697/cytosolic-hsp90%C3%AE-and-its-mitochondrial-isoform-trap1-are-differentially-required-in-a-breast-cancer-model
#18
Evangelia Vartholomaiou, Marta Madon-Simon, Stéphane Hagmann, Guillaume Mühlebach, Wolfgang Wurst, Thomas Floss, Didier Picard
The Hsp90 family of molecular chaperones includes the cytosolic isoforms Hsp90α and Hsp90β, and the mitochondrial isoform Trap1. Hsp90α/β support a large number of client proteins in the cytoplasm and the nucleus whereas Trap1 regulates oxidative phosphorylation in mitochondria. Many of the associated proteins and cellular processes are relevant to cancer, and there is ample pharmacological and genetic evidence to support the idea that Hsp90α/β and Trap1 are required for tumorigenesis. However, a direct and comparative genetic test in a mouse cancer model has not been done...
March 14, 2017: Oncotarget
https://www.readbyqxmd.com/read/28395559/management-of-myelofibrosis-jak-inhibition-and-beyond
#19
Maximilian Stahl, Amer M Zeidan
Myelofibrosis (MF) is characterized by bone marrow fibrosis with subsequent extramedullary hematopoiesis and abnormal cytokine expression leading to splenomegaly, constitutional symptoms and cytopenias. The discovery of the JAK2 V617F mutation in the majority of MF patients has been followed by significant progress in drug development for MF. Areas covered: In this article, we review advances in the understanding of the underlying disease biology, prognostic assessment and therapeutic modalities for MF. We provide clinical trial evidence behind using the JAK2 inhibitor ruxolitinib, erythropoiesis stimulating agents, androgens, immunomodulatory drugs, interferon, cytoreductive drugs and hypomethylating agents in MF...
April 11, 2017: Expert Review of Hematology
https://www.readbyqxmd.com/read/28393858/hili-destabilizes-microtubules-by-suppressing-phosphorylation-and-gigaxonin-mediated-degradation-of-tbcb
#20
Hao Tan, Hua Liao, Lianfang Zhao, Yilu Lu, Siyuan Jiang, Dachang Tao, Yunqiang Liu, Yongxin Ma
Human PIWIL2, aka HILI, is a member of PIWI protein family and overexpresses in various tumors. However, the underlying mechanisms of HILI in tumorigenesis remain largely unknown. TBCB has a critical role in regulating microtubule dynamics and is overexpressed in many cancers. Here we report that HILI inhibits Gigaxonin-mediated TBCB ubiquitination and degradation by interacting with TBCB, promoting the binding between HSP90 and TBCB, and suppressing the interaction between Gigaxonin and TBCB. Meanwhile, HILI can also reduce phosphorylation level of TBCB induced by PAK1...
April 10, 2017: Scientific Reports
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