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https://www.readbyqxmd.com/read/28429826/effect-of-alpha-lipoic-acid-on-endometrial-implants-in-an-experimental-rat-model
#1
Neslihan Pınar, Oya Soylu Karapınar, Oğuzhan Özcan, Tümay Özgür, Suphi Bayraktar
To investigate the antioxidant and anti-inflammatory effects of alpha-lipoic acid (ALA) in the treatment of endometriosis in an experimental rat model by evaluating biochemical and histopathologic parameters. Experimental endometriosis was induced by the peritoneal implantation of autologous endometrial tissue. The rats were randomly divided into two groups with 8 rats each. Group I was intraperitoneally administered ALA 100 mg/kg/day for 14 days. Group II was intraperitoneally administered saline solution at the same dosage and over the same period...
April 21, 2017: Fundamental & Clinical Pharmacology
https://www.readbyqxmd.com/read/28383711/synergistic-effect-of-regulatory-t-cells-and-proinflammatory-cytokines-in-angiogenesis-in-the-endometriotic-milieu
#2
Xiao-Qiu Wang, Wen-Jie Zhou, Xue-Zhen Luo, Yu Tao, Da-Jin Li
STUDY QUESTION: Do regulatory T cells (Tregs) contribute to angiogenesis in endometriosis? SUMMARY ANSWER: High levels of CCL17 and CCL22 cause the recruitment of Tregs, upregulate the immunosuppression of Tregs and, in turn, may promote angiogenesis in endometrial cells in synergy with proinflammatory cytokines. WHAT IS ALREADY KNOWN: The peritoneal fluid of patients with endometriosis has a higher percentage of Tregs than that of normal individuals; however, the regulatory role of Tregs in the disease remains unclear...
April 4, 2017: Human Reproduction
https://www.readbyqxmd.com/read/28383326/a-new-diagnostic-and-prognostic-marker-in-endometrial-cancer-neopterin
#3
Esra Isci Bostanci, Asiye Ugras Dikmen, Gozde Girgin, Tayfun Gungor, Terken Baydar, Ahmet Nuri Danisman
OBJECTIVE: In this study, we investigated the correlation between serum and urinary neopterin levels as well as the stage of the disease in women with endometrial cancer.Increased neopterin concentrations are reported in patients with activation of macrophages by interferon-γ, which includes the following: viral infections, autoimmune disorders, allograft rejection, and various malignant tumors. In patients with several types of cancer, high-neopterin concentrations in body fluids like serum/plasma, urine, ascites, and cerebrospinal fluid indicate the course of the disease, and it is associated with poor prognosis...
April 5, 2017: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/28382901/uterus-like-masses-in-a-rhesus-macaque-macaca-mulatta
#4
Mary F Dickerson, Lauren D Martin, Anne D Lewis
Endometriosis is a relatively common condition in women and some populations of adult female rhesus macaques. However,endometriosis with extensive smooth muscle proliferation, as occurs in endomyometrioma and uterus-like mass (ULM), is rare inwomen. This report describes a case of endometriosis with extensive smooth muscle metaplasia resembling multiple ULM in a20-y-old female rhesus macaque. During a protocol-related procedure, a large, smooth, globoid, freely moveable mass was palpated in the midabdomen. Ultrasonography revealed a cystic structure from which dark brown fluid was aspirated...
April 5, 2017: Comparative Medicine
https://www.readbyqxmd.com/read/28340140/lipidomic-profiling-of-endometrial-fluid-in-women-with-ovarian-endometriosis
#5
Francisco Domínguez, Marcos Ferrando, Patricia Díaz-Gimeno, Fernando Quintana, Gemma Fernández, Inés Castells, Carlos Simón
The proteomic content of the endometrial fluid from patients with endometriosis has been investigated, but the lipidomic profile has not been analyzed yet in detail. This study is a comparative untargeted lipidomic analysis of human endometrial fluid obtained from thirty-five patients (12 endometriosis and 23 controls). Global differential lipidomic profile was analyzed in both groups by ultrahigh performance liquid chromatography (UPLC) coupled to mass spectrometry (MS). 123 out of the 457 metabolites identified in the endometrial fluid were found to be significantly differentially expressed between ovarian endometriosis versus controls...
March 18, 2017: Biology of Reproduction
https://www.readbyqxmd.com/read/28300844/il-27-triggers-il-10-production-in-th17-cells-via-a-c-maf-ror%C3%AE-t-blimp-1-signal-to-promote-the-progression-of-endometriosis
#6
Kai-Kai Chang, Li-Bing Liu, Li-Ping Jin, Bing Zhang, Jie Mei, Hui Li, Chun-Yan Wei, Wen-Jie Zhou, Xiao-Yong Zhu, Jun Shao, Da-Jin Li, Ming-Qing Li
Endometriosis is an estrogen-dependent inflammatory disease. The anti-inflammatory cytokine IL-10 is also increased in endometriosis. IL-10 production by Th17 cells is critical for limiting autoimmunity and inflammatory responses. However, the mechanism of inducing IL-10-producing Th17 cells is still largely unknown. The present study investigated the differentiation mechanism and role of IL-10-producing Th17 cells in endometriosis. Here, we report that IL-10(+)Th17 cells are significantly increased in the peritoneal fluid of women with endometriosis, along with an elevation of IL-27, IL-6 and TGF-β...
March 16, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/28277116/regulation-of-endometrial-cell-proliferation-by-estrogen-induced-bdnf-signaling-pathway
#7
Fangzheng Dong, Qiyao Zhang, Wei Kong, Jun Chen, Junlan Ma, Li Wang, Yanian Wang, Yan Liu, Yan Li, Ji Wen
Brain-derived neurotrophic factor (BDNF) is a member of the neurotrophin growth factors family. Recent studies indicated that the level of BDNF in follicular fluid is a marker for oocyte quality and infertility. Here, we intend to further investigate the function of BDNF and its signaling pathway in the regulation of endometrial cells proliferation. We found that BDNF is a critical growth factor in endometrial cells. Activation of signal transducer and activator of transcription 3 signaling pathway is required for BNDF-regulated endometrial cell proliferation...
March 2, 2017: Gynecological Endocrinology
https://www.readbyqxmd.com/read/28270540/creatinine-concentrations-of-accumulated-intrauterine-fluid-to-confirm-the-clinical-diagnosis-of-urometra-in-mares
#8
M R Schnobrich, D L Gordon, C F Scoggin, E A Bradecamp, I F Canisso
Urine pooling, as a persistent condition, is a cause of infertility in mares due to endometrial inflammation and sperm toxicity. Identification of urometra can be challenging in mares presenting with the condition intermittently, or when urine flows into the uterus but is undetectable in the vagina. Currently, there are no reported objective methods to confirm the clinical diagnosis of urine contamination in intrauterine-fluid accumulations. Since creatinine is present in high concentrations in urine and does not diffuse across cell membranes, creatinine concentration should be increased in mares with urometra, but negligible in normal and mares with intrauterine fluid accumulation (non-urometra cases)...
March 25, 2017: Veterinary Record
https://www.readbyqxmd.com/read/28252269/endometrial-sampling-before-or-after-saline-infusion-sonography-espresso-trial-a-national-survey-and-a-study-protocol-of-a-multicenter-rct
#9
Albertine J Vroom, Marileen M Prins, Marlies Y Bongers, Peggy M Geomini, Anne Timmermans, Nehallenia van Hanegem
Postmenopausal bleeding can be the first clinical sign of an endometrial abnormality. Because of an increased risk of malignancy, evaluation is advocated. Polyps are reported up to 40% in women with postmenopausal bleeding. These polyps carry a risk of 6% for a focal (pre-) malignancy. To perform complete diagnostic work-up, recent guidelines recommend endometrial sampling and a saline infusion sonography if a previous transvaginal ultrasound shows an endometrial thickness of more than 4 mm. The current guideline shows no consensus of the sequence of both diagnostic procedures...
June 2017: Minerva Ginecologica
https://www.readbyqxmd.com/read/28246486/pancreatic-endometrial-cyst-mimics-mucinous-cystic-neoplasm-of-the-pancreas
#10
Michael A Mederos, Nicole Villafañe, Sadhna Dhingra, Carlos Farinas, Amy McElhany, William E Fisher, George Van Buren Ii
Pancreatic cysts include a variety of benign, premalignant, and malignant lesions. Endometrial cysts in the pancreas are exceedingly rare lesions that are difficult to diagnose pre-operatively. This report describes the findings in a 43-year-old patient with a recent episode of acute pancreatitis who presented with a large cyst in the tail of the pancreas. Imaging demonstrated a loculated pancreatic cyst, and cyst fluid aspiration revealed an elevated amylase and carcinoembryonic antigen. The patient experienced an interval worsening of abdominal pain, fatigue, diarrhea, and a 15-pound weight loss 3 mo after the initial episode of pancreatitis...
February 14, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28240436/the-ccl17-ccr4-axis-between-endometrial-stromal-cells-and-macrophages-contributes-to-the-high-levels-of-il-6-in-ectopic-milieu
#11
Wen-Jie Zhou, Xin-Xin Hou, Xiao-Qiu Wang, Da-Jin Li
Endometriosis is a chronic inflammatory disease characterized by the elevation of proinflammatory cytokines, such as IL-6, in the peritoneal fluid. However, the precise mechanism of the highly elevated IL-6 levels in ectopic milieu remains unclear. The aim of this study was to investigate whether the cross talk between endometrial stromal cells (ESCs) and macrophages contributes to the elevated IL-6 production. Samples of endometrium and ectopic tissues were obtained from patients with or without endometriosis...
February 27, 2017: American Journal of Reproductive Immunology: AJRI
https://www.readbyqxmd.com/read/28215895/short-communication-repeat-breeder-cows-with-fluid-in-the-uterine-lumen-had-poorer-fertility
#12
M Jaureguiberry, M J Giuliodori, A V Mang, L V Madoz, H Pothmann, M Drillich, R L de la Sota
The objective of the present study was to test the association between the presence of fluid in uterine lumen and the fertility of repeat breeder cows (RBC). Grazing Holstein cows that were clinically normal and were not pregnant after at least 3 consecutive inseminations were defined as RBC and included in the study (n = 358). A cut-point ≥2 mm of uterine lumen visible by ultrasonography was used as indicative of the presence of fluid in the uterus. The effect of this fluid on the fertility of RBC was assessed by mixed logistic regression...
February 16, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28166962/expression-and-localization-of-artemin-in-the-bovine-uterus-and-embryos
#13
E Gómez, D Martin, S Carrocera, M J Sánchez-Calabuig, A Gutierrez-Adán, M Alonso-Guervos, N Peynot, C Giraud-Delville, O Sandra, V Duranthon, M Muñoz
Artemin a member of the glial cell line-derived neurotrophic factor (GDNF) family is present in mice and human preimplantation embryos, and reproductive tract, during early pregnancy promoting embryo development in vitro. The presence of artemin in cattle embryos and reproductive tract, however, is unknown. In the present work we identified for first time artemin in bovine uterine fluid (UF) (Western blot), endometrium (RT-PCR, Western blot and immunohistochemistry) and embryos (RT-PCR and immunohistochemistry) during early preimplantation development...
March 1, 2017: Theriogenology
https://www.readbyqxmd.com/read/28120482/abnormal-peritoneal-regulation-of-chemokine-activation-the-role-of-il-8-in-pathogenesis-of-endometriosis
#14
Justyna Sikora, Marta Smycz-Kubańska, Aleksandra Mielczarek-Palacz, Zdzisława Kondera-Anasz
PROBLEM: Endometriosis is a chronic inflammatory disease associated with an impairment in immune response. Disorders in the peritoneal fluid and ectopic endometrium macrophage populations and their secretory products create a specific microenvironment inducing the development of the disease. The important factors involved in inflammation associated with endometriosis are chemokines, especially interleukin (IL)-8. For this reason, the current study briefly reviews the role of IL-8 in the pathogenesis of endometriosis...
January 25, 2017: American Journal of Reproductive Immunology: AJRI
https://www.readbyqxmd.com/read/28117603/he4-test-of-urine-and-body-fluids-for-diagnosis-of-gynecologic-cancer
#15
Wanglei Qu, Quansheng Gao, Haibin Chen, Zuoqing Tang, Xueqiong Zhu, Shi-Wen Jiang
Serum epididymis protein 4 (HE4) level is a useful biomarker for the management of ovarian and endometrial cancer patients. Urine HE4-test, with its easier access than serum test, has emerged as a new method with promising application for the diagnosis of ovarian cancer. Areas covered: This review summarizes data regarding the detection and alteration of HE4 in urine samples collected from ovarian cancer patients and controls. The performance and limitation of the assay and potential direction of future study are also discussed...
March 2017: Expert Review of Molecular Diagnostics
https://www.readbyqxmd.com/read/28089717/persistent-organic-pollutants-pops-in-human-follicular-fluid-and-in-vitro-fertilization-outcomes-a-pilot-study
#16
Michael S Bloom, Victor Y Fujimoto, Robin Storm, Li Zhang, Celeste D Butts, Diana Sollohub, Robert L Jansing
Persistent organic pollutants (POPs) are ubiquitously distributed among the U.S. population and adversely impact human reproduction. These compounds have been detected in human ovarian follicular fluid (FF), where they directly contact a developing oocyte. As a pilot investigation, we measured 43 polychlorinated biphenyl (PCB) congeners, p,p'-dichlorodiphenyltrichloroethane (DDT), and its persistent metabolite p,p'-dichlorodiphenyldichloroethylene (DDE) in residual FF collected from 32 women undergoing in vitro fertilization (IVF)...
January 2017: Reproductive Toxicology
https://www.readbyqxmd.com/read/28063264/preimplantation-3d-ultrasound-current-uses-and-challenges
#17
Sushila Arya, Sanja Kupesic Plavsic
The preimplantation ultrasound (US) refers to targeted imaging of the uterus and adnexa prior to assisted reproductive techniques (ART) to optimize the infertility treatment outcomes. After a thorough evidence based literature review, we propose the use of transvaginal three-dimensional (3D) US during the early follicular phase. A systematic approach for 3D US examination consists of a detailed examination of the uterine shape, size and contour, evaluation of the endometrial thickness, volume, pattern and vascularity, and assessment of the junctional zone regularity, echogenicity and thickness...
January 7, 2017: Journal of Perinatal Medicine
https://www.readbyqxmd.com/read/28057913/humoral-hypercalcemia-in-uterine-cancers-a-case-report-and-literature-review
#18
REVIEW
Vijeyaluxmy Motilal Nehru, Gwenalyn Garcia, Juan Ding, Fanyi Kong, Qun Dai
BACKGROUND Paraneoplastic hypercalcemia is a well-described complication associated with a variety of malignancies. However, its incidence in gynecological malignancies is low. CASE REPORT A 53-year-old woman presented with progressive abdominal distention and irregular vaginal bleeding of several weeks' duration. A contrast CT abdomen and pelvis was significant for a mass in the lower uterine/cervical region, multiple peritoneal and omental masses, enlarged pelvic and paraaortic lymph nodes, and large-volume ascites...
January 6, 2017: American Journal of Case Reports
https://www.readbyqxmd.com/read/28042542/oxidative-stress-statues-in-serum-and-follicular-fluid-of-women-with-endometriosis
#19
Nahid Nasiri, Ashraf Moini, Poopak Eftekhari-Yazdi, Leila Karimian, Reza Salman-Yazdi, Arezoo Arabipoor
OBJECTIVE: This study aimed to evaluate the levels of two oxidative stress (OS) markers including lipid peroxide (LPO) and total antioxidant capacity (TAC) in both serum and follicular fluid (FF) of women with endometriosis after puncture. MATERIALS AND METHODS: In this cross-sectional study, a total number of sixty-three women younger than 40 years old with laparoscopy (gold standard for endometriosis diagnosis) indication underwent in vitro fertilization (IVF) program in the Royan Institute, Tehran, Iran from September 2013 to October 2014...
2017: Cell Journal
https://www.readbyqxmd.com/read/28040129/efficacies-of-vitamin-d-and-omega-3-polyunsaturated-fatty-acids-on-experimental-endometriosis
#20
Alpaslan Akyol, Memet Şimşek, Raşit İlhan, Behzat Can, Melike Baspinar, Hadice Akyol, H Fatih Gül, Ferit Gürsu, Burçin Kavak, Mustafa Akın
OBJECTIVE: The aim of this study was to investigate the effects of 1,25-dihydroxyvitamin-D3 (vitamin D) and omega-3 polyunsaturated fatty acids (omega-3 PUFA) on experimentally induced endometriosis in a rat model. MATERIALS AND METHODS: A prospective, single-blind, randomized, controlled experimental study was performed on 30 Wistar female rats. Endometriosis was surgically induced by implanting endometrial tissue on the abdominal peritoneum. Four weeks later, a second laparotomy was performed to assess pre-treatment implant volumes and cytokine levels...
December 2016: Taiwanese Journal of Obstetrics & Gynecology
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