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Hpv head neck hiv

Manuela Ceccarelli, Emmanuele Venanzi Rullo, Alessio Facciolà, Giordano Madeddu, Bruno Cacopardo, Rosaria Taibi, Francesco D'Aleo, Marilia Rita Pinzone, Isa Picerno, Michele di Rosa, Giuseppa Visalli, Fabrizio Condorelli, Giuseppe Nunnari, Giovanni Francesco Pellicanò
Over the last 20 years we assisted to an increase in the mean age of People Living with HIV and their comorbidities. Especially, there was an increase in Human Papillomavirus-related head and neck squamous cell carcinomas. Despite their increasing incidence in HIV-positive people, mechanisms that lead to their development and progression are only partially understood. The aim of this review is to identify key data and factors about HPV-related head and neck squamous cell carcinoma in HIV-seropositive patients...
March 30, 2018: Oncotarget
S Camacho-Aguilar, V Ramírez-Amador, P Rosendo-Chalma, M Guido-Jiménez, A García-Carrancá, G Anaya-Saavedra
BACKGROUND: Although HPV emerged as a crucial carcinogenic and prognostic biomarker in head and neck cancer, and considering the increase in HPV-associated oral lesions (HPV-OLs) in HIV individuals, molecular information about HPV-OLs is scarce; thus, our aim was to determine viral loads in HPV-OLs from HIV/AIDS individuals. METHODS: HIV/AIDS subjects with HPV-OL were included in this cross-sectional study. Following informed consent, biopsies were obtained. HPV detection and typing were carried out by PCR and sequencing (MY09/11, GP5+/6+)...
March 2018: Oral Diseases
Itzel Castillejos-García, Velia A Ramírez-Amador, Adela Carrillo-García, Alejandro García-Carrancá, Marcela Lizano, Gabriela Anaya-Saavedra
BACKGROUND: Oral high-risk human papillomavirus (HR-HPV) infections are frequent and persistent among the HIV-positive population and are associated with an increased risk for head and neck cancer (HNC). In this study, we sought to determine the incidence, persistence and clearance of HPV infections in oral and oropharyngeal samples from HIV/AIDS subjects. METHODS: A longitudinal, observational and analytical study was performed with an ongoing cohort of HIV/AIDS subjects in Mexico City (September 2013-February 2015)...
April 2018: Journal of Oral Pathology & Medicine
Bridget K M Lekoane, Tivani P Mashamba-Thompson, Themba G Ginindza
BACKGROUND: Despite the introduction of HPV vaccines, the incidence of HPV-related cancers (cervical, penile, anal, vulvar, vagina, head, and neck) in sub-Saharan Africa has been rising. The increasing incidence of these HPV-related cancers has been attributed to changes in lifestyle-related risk factors, most notably sexual behavior. The main objective of this study is to map evidence on the distribution of HIV-related cancers in sub-Saharan Africa (SSA). METHODS AND ANALYSIS: We will conduct a scoping review to explore, describe, and map literature on the distribution of HPV-related cancers in sub-Saharan Africa...
November 17, 2017: Systematic Reviews
Frederico O Gleber-Netto, Mei Zhao, Sanchit Trivedi, Jiping Wang, Samar Jasser, Christina McDowell, Humam Kadara, Jiexin Zhang, Jing Wang, William N William, J Jack Lee, Minh Ly Nguyen, Sara I Pai, Heather M Walline, Dong M Shin, Robert L Ferris, Thomas E Carey, Jeffrey N Myers, Curtis R Pickering
BACKGROUND: Human immunodeficiency virus-infected individuals (HIVIIs) have a higher incidence of head and neck squamous cell carcinoma (HNSCC), and clinical and histopathological differences have been observed in their tumors in comparison with those of HNSCC patients without a human immunodeficiency virus (HIV) infection. The reasons for these differences are not clear, and molecular differences between HIV-related HNSCC and non-HIV-related HNSCC may exist. This study compared the mutational patterns of HIV-related HNSCC and non-HIV-related HNSCC...
January 1, 2018: Cancer
Claire E Faggons, Charles E Mabedi, N George Liomba, William K Funkhouser, Fred Chimzimu, Coxcilly Kampani, Robert Krysiak, Nelson Msiska, Carol G Shores, Satish Gopal
BACKGROUND: Head and neck squamous cell carcinoma (HNSCC) is common in sub-Saharan Africa, but the aetiologic contribution of human papillomavirus (HPV) is not well established. METHODS: We assessed HNSCC cases for HPV using p16 immunohistochemistry (IHC) in Malawi. Associations between p16 IHC and tumour site, behavioural risk factors, demographic characteristics, and HIV status were examined. RESULTS: From 2010 to 2014, 77 HNSCC cases were identified...
June 2017: Malawi Medical Journal: the Journal of Medical Association of Malawi
Francesca Rollo, Alessandra Latini, Barbara Pichi, Manuela Colafigli, Maria Benevolo, Ilenia Sinopoli, Isabella Sperduti, Valentina Laquintana, Giulia Fabbri, Mirko Frasca, Antonio Cristaudo, Massimo Giuliani, Maria Gabriella Donà
BACKGROUND: Oral Human Papillomavirus (HPV) infection is rare in the general population but common in high-risk individuals. Recent data indicate that oral HPV is associated with the development of head and neck carcinomas. HPV16 infection, in particular, increases the risk of oropharyngeal cancer. METHODS: We evaluated oral HPV prevalence and determinants of infection in cancer-free HIV-infected and uninfected men who have sex with men (MSM) recruited among attendees of an STI/HIV centre...
2017: PloS One
Giuseppe Vittorio De Socio, Olena Bidovanets, Gian Marco Tomassini, Luca Fanelli, Stefano Simonetti
Human papillomavirus (HPV) infection, widely known as the necessary cause of cervical cancer, has been established as a major etiologic factor for head and neck cancer (HNC). HIV-infected individuals are at higher risk of HPV-associated cancers than the general population. We describe a 45-year-old man with HIV and HPV coinfection, who presented progressively enlarging verrucous neoformations of the lips. The final diagnosis of verrucous carcinoma was delayed. Early detection of HPV lesions in oral mucosa and HPV screening activities could be important in improving the diagnostic sensitivity for the HIV-infected patients with oral cancer...
January 1, 2017: Journal of the International Association of Providers of AIDS Care
Heather M Walline, Thomas E Carey, Christine M Goudsmit, Emily L Bellile, Gypsyamber D'Souza, Lisa A Peterson, Jonathan B McHugh, Sara I Pai, J Jack Lee, Dong M Shin, Robert L Ferris
In this study, high-risk HPV (hrHPV) incidence, prognostic biomarkers, and outcome were assessed in HIV-positive (case) and HIV-negative (control) patients with head and neck squamous cell cancer (HNSCC). HIV-positive cases were matched to controls by tumor site, sex, and age at cancer diagnosis. A tissue microarray (TMA) was constructed and DNA isolated from tumor tissue. MultiPlex-PCR MassArray, L1-PCR, and in situ hybridization were used to assess hrHPV. TMA sections were stained for p16ink4a, TP53, RB, CCND1, EGFR, and scored for intensity and proportion of positive tumor cells...
February 2017: Molecular Cancer Research: MCR
J T Guidry, R S Scott
The etiological role of human papillomavirus (HPV) in anogenital tract and head and neck cancers is well established. However, only a low percentage of HPV-positive women develop cancer, indicating that HPV is necessary but not sufficient in carcinogenesis. Several biological and environmental cofactors have been implicated in the development of HPV-associated carcinoma that include immune status, hormonal changes, parity, dietary habits, tobacco usage, and co-infection with other sexually transmissible agents...
March 2, 2017: Virus Research
C C Wang, J M Palefsky
Human papillomavirus (HPV) is a common sexually transmitted virus and an important etiologic factor in head and neck cancers. HIV-infected individuals are at increased risk of developing oropharyngeal cancers (OPC) compared with the general population. HPV-positive OPC are also increasingly a significant cause of morbidity and mortality for HIV-infected individuals in the era of effective combination antiretroviral therapy. The epidemiology and natural history of oral HPV infection have not been well established, but it appears that oral HPV infection is less common than anal infection, and more common among HIV-infected persons than the general population...
April 2016: Oral Diseases
Fariba S Younai
The prevalence and behavior of oropharyngeal cancers have dramatically changed over the past 30 years. It is now clear that human papillomavirus (HPV) plays a major role in the incidence of head and neck cancers in the general population and among patients with HIV infection. This article reviews the current knowledge about oropharyngeal cancers for their epidemiology, pathogenesis, clinical behavior, treatment and prevention. This review further examines the subset of oropharyngeal cancers among the HIV-seropositive patients...
February 2016: Journal of the California Dental Association
Annabelle Picard, Cécile Badoual, Muriel Hourseau, Caroline Halimi, Hélène Pere, Fadia Dib, Béatrix Barry, Sébastien Albert
OBJECTIVE: The implication of human papilloma virus (HPV) in head and neck squamous cell carcinoma (HNSCC) is well established, especially in oropharyngeal SCC. HIV patients have a higher risk of persistent HPV infection. We investigated the role of HPV in HNSCC carcinogenesis in HIV population. DESIGN: Retrospective monocentric study. METHODS: We studied HIV patients who presented with HNSCC between 1994 and 2014. For each patient, tumor characteristics, HIV disease, and survival information were collected...
May 15, 2016: AIDS
C E Faggons, C Mabedi, C G Shores, S Gopal
AIM: Review the literature from 1990 to 2013 to determine known anatomic sites, risk factors, treatments, and outcomes of head and neck squamous cell carcinoma (HNSCC) in sub-Saharan Africa. METHODS: Using a systematic search strategy, literature pertaining to HNSCC in sub-Saharan Africa was reviewed and patient demographics, anatomic sites, histology, stage, treatment, and outcomes were abstracted. The contributions of human immunodeficiency virus (HIV), human papillomavirus (HPV) and behavioural risk factors to HNSCC in the region were assessed...
September 2015: Malawi Medical Journal: the Journal of Medical Association of Malawi
(no author information available yet)
No abstract text is available yet for this article.
April 21, 2015: Oncology (Williston Park, NY)
Eleanor M King, Richard Gilson, Simon Beddows, Kate Soldan, Kavita Panwar, Carmel Young, Mark Jit, W John Edmunds, Pam Sonnenberg
OBJECTIVES: To estimate the prevalence of oral detectable human papillomavirus (HPV) DNA in HIV-negative men who have sex with men (MSM) attending a sexual health clinic in London and concordance with anogenital HPV infection. Such data are important to improve our understanding of the epidemiology of oral HPV and the potential use of vaccines to prevent oropharyngeal cancers. METHODS: Paired oral rinse samples and anogenital samples were available from 151 HIV-negative MSM within a larger cross-sectional survey...
June 2015: Sexually Transmitted Infections
Nosayaba Osazuwa-Peters, Dawei David Wang, Arya Namin, Vivek Mathew John, John Vivek, Michael O'Neill, Pranav V Patel, Mark A Varvares
OBJECTIVES: To understand knowledge of HPV, its association with head and neck cancer (HNC), and source of knowledge in a high-risk population. MATERIALS AND METHODS: A cross-sectional survey was conducted among attendees at a Drag Racing event in East St. Louis in 2013. RESULTS: Only 29.9% knew that HPV definitely increases the risk of developing HNC, 42.4% thought HPV was same as HIV, and only 25.1% received HPV information from a healthcare practitioner...
May 2015: Oral Oncology
Seye Abogunrin, Gian Luca Di Tanna, Sam Keeping, Stuart Carroll, Ike Iheanacho
BACKGROUND: Infection with human papillomavirus (HPV) is necessary for the development of cervical carcinoma. By contrast, the role of HPV in the pathogenesis of other malignancies, such as head and neck cancers, is less well characterised. This study aimed to address key information gaps by conducting a systematic review and meta-analysis of the prevalence of HPV infection in head and neck cancers, focusing on data for European populations. METHODS: MEDLINE, Embase and grey literature sources were systematically searched for primary studies that were published in English between July 2002 and July 2012, and which reported on the prevalence of HPV infection in head and neck cancers in European populations...
2014: BMC Cancer
Daniel C Beachler, Alison G Abraham, Michael J Silverberg, Yuezhou Jing, Carole Fakhry, M John Gill, Robert Dubrow, Mari M Kitahata, Marina B Klein, Ann N Burchell, P Todd Korthuis, Richard D Moore, Gypsyamber D'Souza
OBJECTIVES: To examine the risk and trends of HPV-related and HPV-unrelated Head and Neck Squamous Cell Carcinoma (HNSCC) in HIV-infected individuals and assess whether immunosuppression (measured through CD4 cell count) and other risk factors impact HNSCC risk. MATERIALS AND METHODS: Incident HNSCCs at HPV-related and HPV-unrelated anatomic sites were detected in HIV-infected participants from pooled data from 17 prospective studies in the North American AIDS Cohort Collaboration on Research and Design (NA-ACCORD) between 1996 and 2009...
December 2014: Oral Oncology
Christy Lana Davidson, Karin Louise Richter, Mike Van der Linde, Judy Coetsee, Sonja Catharina Boy
BACKGROUND: Human papillomavirus (HPV) infection is well known to be associated with head and neck cancers (HNCs). HPV-associated HNCs are related to sexual behaviour, particularly the lifetime number of oral sex partners, but the epidemiology of oral and oropharyngeal HPV in South African men has not yet been studied. OBJECTIVES: To determine the oral and oropharyngeal HPV strain prevalence and associated factors in a selected male population in Pretoria, South Africa (SA)...
May 2014: South African Medical Journal, Suid-Afrikaanse Tydskrif Vir Geneeskunde
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