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https://www.readbyqxmd.com/read/27899422/high-risk-hpv-biomarkers-and-outcome-in-matched-cohorts-of-head-and-neck-cancer-patients-positive-and-negative-for-hiv
#1
Heather M Walline, Thomas E Carey, Christine M Goudsmit, Emily L Bellile, Gypsyamber D'souza, Lisa A Peterson, Jonathan B McHugh, Sara I Pai, J Jack Lee, Dong M Shin, Robert L Ferris
: In this study, high-risk HPV (hrHPV) incidence, prognostic biomarkers, and outcome were assessed in HIV-positive (case) and HIV-negative (control) patients with head and neck squamous cell cancer (HNSCC). HIV-positive cases were matched to controls by tumor site, sex, and age at cancer diagnosis. A tissue microarray (TMA) was constructed and DNA isolated from tumor tissue. MultiPlex-PCR MassArray, L1-PCR and In Situ Hybridization were used to assess hrHPV. TMA sections were stained for p16ink4a, TP53, RB, CCND1, EGFR, and scored for intensity and proportion of positive tumor cells...
November 29, 2016: Molecular Cancer Research: MCR
https://www.readbyqxmd.com/read/27826043/the-interaction-between-human-papillomavirus-and-other-viruses
#2
REVIEW
J T Guidry, R S Scott
The etiological role of human papillomavirus (HPV) in anogenital tract and head and neck cancers is well established. However, only a low percentage of HPV-positive women develop cancer, indicating that HPV is necessary but not sufficient in carcinogenesis. Several biological and environmental cofactors have been implicated in the development of HPV-associated carcinoma that include immune status, hormonal changes, parity, dietary habits, tobacco usage, and co-infection with other sexually transmissible agents...
November 5, 2016: Virus Research
https://www.readbyqxmd.com/read/27109278/human-papillomavirus-related-oropharyngeal-cancer-in-the-hiv-infected-population
#3
C C Wang, J M Palefsky
Human papillomavirus (HPV) is a common sexually transmitted virus and an important etiologic factor in head and neck cancers. HIV-infected individuals are at increased risk of developing oropharyngeal cancers (OPC) compared with the general population. HPV-positive OPC are also increasingly a significant cause of morbidity and mortality for HIV-infected individuals in the era of effective combination antiretroviral therapy. The epidemiology and natural history of oral HPV infection have not been well established, but it appears that oral HPV infection is less common than anal infection, and more common among HIV-infected persons than the general population...
April 2016: Oral Diseases
https://www.readbyqxmd.com/read/26930752/current-trends-in-the-incidence-and-presentation-of-oropharyngeal-cancer
#4
REVIEW
Fariba S Younai
The prevalence and behavior of oropharyngeal cancers have dramatically changed over the past 30 years. It is now clear that human papillomavirus (HPV) plays a major role in the incidence of head and neck cancers in the general population and among patients with HIV infection. This article reviews the current knowledge about oropharyngeal cancers for their epidemiology, pathogenesis, clinical behavior, treatment and prevention. This review further examines the subset of oropharyngeal cancers among the HIV-seropositive patients...
February 2016: Journal of the California Dental Association
https://www.readbyqxmd.com/read/26807970/human-papilloma-virus-prevalence-in-hiv-patients-with-head-and-neck-squamous-cell-carcinoma
#5
Annabelle Picard, Cécile Badoual, Muriel Hourseau, Caroline Halimi, Hélène Pere, Fadia Dib, Béatrix Barry, Sébastien Albert
OBJECTIVE: The implication of human papilloma virus (HPV) in head and neck squamous cell carcinoma (HNSCC) is well established, especially in oropharyngeal SCC. HIV patients have a higher risk of persistent HPV infection. We investigated the role of HPV in HNSCC carcinogenesis in HIV population. DESIGN: Retrospective monocentric study. METHODS: We studied HIV patients who presented with HNSCC between 1994 and 2014. For each patient, tumor characteristics, HIV disease, and survival information were collected...
May 15, 2016: AIDS
https://www.readbyqxmd.com/read/26715951/review-head-and-neck-squamous-cell-carcinoma-in-sub-saharan-africa
#6
REVIEW
C E Faggons, C Mabedi, C G Shores, S Gopal
AIM: Review the literature from 1990 to 2013 to determine known anatomic sites, risk factors, treatments, and outcomes of head and neck squamous cell carcinoma (HNSCC) in sub-Saharan Africa. METHODS: Using a systematic search strategy, literature pertaining to HNSCC in sub-Saharan Africa was reviewed and patient demographics, anatomic sites, histology, stage, treatment, and outcomes were abstracted. The contributions of human immunodeficiency virus (HIV), human papillomavirus (HPV) and behavioural risk factors to HNSCC in the region were assessed...
September 2015: Malawi Medical Journal: the Journal of Medical Association of Malawi
https://www.readbyqxmd.com/read/25930770/-s008-%C3%A2-the-impact-of-hpv-hiv-and-smoking-on-oncologic-and-functional-outcomes-in-patients-with-head-and-neck-cancer
#7
(no author information available yet)
No abstract text is available yet for this article.
April 21, 2015: Oncology (Williston Park, NY)
https://www.readbyqxmd.com/read/25887283/oral-human-papillomavirus-hpv-infection-in-men-who-have-sex-with-men-prevalence-and-lack-of-anogenital-concordance
#8
Eleanor M King, Richard Gilson, Simon Beddows, Kate Soldan, Kavita Panwar, Carmel Young, Mark Jit, W John Edmunds, Pam Sonnenberg
OBJECTIVES: To estimate the prevalence of oral detectable human papillomavirus (HPV) DNA in HIV-negative men who have sex with men (MSM) attending a sexual health clinic in London and concordance with anogenital HPV infection. Such data are important to improve our understanding of the epidemiology of oral HPV and the potential use of vaccines to prevent oropharyngeal cancers. METHODS: Paired oral rinse samples and anogenital samples were available from 151 HIV-negative MSM within a larger cross-sectional survey...
June 2015: Sexually Transmitted Infections
https://www.readbyqxmd.com/read/25683135/sexual-behavior-hpv-knowledge-and-association-with-head-and-neck-cancer-among-a-high-risk-group
#9
Nosayaba Osazuwa-Peters, Dawei David Wang, Arya Namin, Vivek Mathew John, John Vivek, Michael O'Neill, Pranav V Patel, Mark A Varvares
OBJECTIVES: To understand knowledge of HPV, its association with head and neck cancer (HNC), and source of knowledge in a high-risk population. MATERIALS AND METHODS: A cross-sectional survey was conducted among attendees at a Drag Racing event in East St. Louis in 2013. RESULTS: Only 29.9% knew that HPV definitely increases the risk of developing HNC, 42.4% thought HPV was same as HIV, and only 25.1% received HPV information from a healthcare practitioner...
May 2015: Oral Oncology
https://www.readbyqxmd.com/read/25515630/prevalence-of-human-papillomavirus-in-head-and-neck-cancers-in-european-populations-a-meta-analysis
#10
REVIEW
Seye Abogunrin, Gian Luca Di Tanna, Sam Keeping, Stuart Carroll, Ike Iheanacho
BACKGROUND: Infection with human papillomavirus (HPV) is necessary for the development of cervical carcinoma. By contrast, the role of HPV in the pathogenesis of other malignancies, such as head and neck cancers, is less well characterised. This study aimed to address key information gaps by conducting a systematic review and meta-analysis of the prevalence of HPV infection in head and neck cancers, focusing on data for European populations. METHODS: MEDLINE, Embase and grey literature sources were systematically searched for primary studies that were published in English between July 2002 and July 2012, and which reported on the prevalence of HPV infection in head and neck cancers in European populations...
2014: BMC Cancer
https://www.readbyqxmd.com/read/25301563/incidence-and-risk-factors-of-hpv-related-and-hpv-unrelated-head-and-neck-squamous-cell-carcinoma-in-hiv-infected-individuals
#11
Daniel C Beachler, Alison G Abraham, Michael J Silverberg, Yuezhou Jing, Carole Fakhry, M John Gill, Robert Dubrow, Mari M Kitahata, Marina B Klein, Ann N Burchell, P Todd Korthuis, Richard D Moore, Gypsyamber D'Souza
OBJECTIVES: To examine the risk and trends of HPV-related and HPV-unrelated Head and Neck Squamous Cell Carcinoma (HNSCC) in HIV-infected individuals and assess whether immunosuppression (measured through CD4 cell count) and other risk factors impact HNSCC risk. MATERIALS AND METHODS: Incident HNSCCs at HPV-related and HPV-unrelated anatomic sites were detected in HIV-infected participants from pooled data from 17 prospective studies in the North American AIDS Cohort Collaboration on Research and Design (NA-ACCORD) between 1996 and 2009...
December 2014: Oral Oncology
https://www.readbyqxmd.com/read/25212204/prevalence-of-oral-and-oropharyngeal-human-papillomavirus-in-a-sample-of-south-african-men-a-pilot-study
#12
Christy Lana Davidson, Karin Louise Richter, Mike Van der Linde, Judy Coetsee, Sonja Catharina Boy
BACKGROUND: Human papillomavirus (HPV) infection is well known to be associated with head and neck cancers (HNCs). HPV-associated HNCs are related to sexual behaviour, particularly the lifetime number of oral sex partners, but the epidemiology of oral and oropharyngeal HPV in South African men has not yet been studied. OBJECTIVES: To determine the oral and oropharyngeal HPV strain prevalence and associated factors in a selected male population in Pretoria, South Africa (SA)...
May 2014: South African Medical Journal, Suid-Afrikaanse Tydskrif Vir Geneeskunde
https://www.readbyqxmd.com/read/24961359/human-papillomavirus-vaccine-acceptance-among-young-men-in-bangalore-india
#13
Hrishikesh Kumar Belani, Poorani Sekar, Rajarshi Guhaniyogi, Anil Abraham, Paul R Bohjanen, Kim Bohjanen
BACKGROUND: Human papillomavirus (HPV) is the most common sexually transmitted infection in the world. It can lead to anogenital, cervical, and head and neck cancer, with higher risk of malignant disease in patients with human immunodeficiency virus (HIV)/acquired immunodeficiency syndrome (AIDS) patients. In India, 73,000 of the 130,000 women diagnosed with cervical cancer die annually. Gardasil(®) , a vaccine available against HPV types 6, 11, 16, and 18, is approved for use in women in India but not men...
November 2014: International Journal of Dermatology
https://www.readbyqxmd.com/read/24462961/new-advances-in-mucosal-vaccination
#14
REVIEW
Charani Ranasinghe
The ICI 2013 Mucosal Vaccine Workshop presentations covered a wide range of topics, these mainly fell into three categories: (i) Understanding the interactions of host and microbes, specifically commensal pathogens and improving the antigen uptake via the (microfold cells) M cells to induce effective IgA antibody immunity at the gut mucosa; (ii) effective plant-based vaccines and (iii) development of prophylactic and therapeutic mucosal-based vaccine strategies for virus infections such as human immunodeficiency virus (HIV), influenza and human papillomavirus (HPV) associated head and neck cancers...
October 2014: Immunology Letters
https://www.readbyqxmd.com/read/24384590/oral-human-papillomavirus-infection-in-hiv-negative-and-hiv-infected-msm
#15
Sofie H Mooij, Hein J Boot, Arjen G C L Speksnijder, Ineke G Stolte, Chris J L M Meijer, Peter J F Snijders, Dominique W M Verhagen, Audrey J King, Henry J C de Vries, Wim G V Quint, Marianne A B van der Sande, Maarten F Schim van der Loeff
OBJECTIVE: Oral infection with human papillomavirus (HPV) is associated with a subset of head and neck cancers. We compared prevalence of, and risk factors for, oral HPV infection among HIV-negative and HIV-infected MSM. DESIGN: Analysis of baseline data from a prospective cohort study. METHODS: MSM aged 18 years or older were recruited from three study sites in Amsterdam, the Netherlands. Participants completed a self-administered risk-factor questionnaire...
August 24, 2013: AIDS
https://www.readbyqxmd.com/read/24326607/epidemiology-of-head-and-neck-squamous-cell-cancer-among-hiv-infected-patients
#16
Gypsyamber Dʼsouza, Thomas E Carey, William N William, Minh Ly Nguyen, Eric C Ko, James Riddell, Sara I Pai, Vishal Gupta, Heather M Walline, J Jack Lee, Gregory T Wolf, Dong M Shin, Jennifer R Grandis, Robert L Ferris
BACKGROUND: HIV-infected individuals have a higher incidence of head and neck cancer (HNC). METHODS: Case series of 94 HIV-infected HNC patients (HIV-HNC) at 6 tertiary care referral centers in the US between 1991 and 2011. Clinical and risk factor data were abstracted from the medical record. Risk factors for survival were analyzed using Cox proportional hazard models. Human papillomavirus (HPV) and p16 testing was performed in 46 tumors. Findings were compared with Surveillance Epidemiology and End Results HNC (US-HNC) data...
April 15, 2014: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/23965778/prevalence-and-type-distribution-of-human-papillomavirus-among-1813-men-in-tanzania-and-the-relationship-to-hiv-status
#17
Tina Bech Olesen, Thomas Iftner, Julius Mwaiselage, Crispin Kahesa, Vibeke Rasch, Twalib Ngoma, Christian Munk, Susanne Krüger Kjaer
BACKGROUND: Infection with high-risk (HR) human papillomavirus (HPV) is associated with penile cancer in men, cervical cancer in women, and anal cancer and certain types of head and neck cancers in both sexes. Few studies have assessed the prevalence and type distribution of HPV among men in sub-Saharan Africa, where the rates of HIV and penile and cervical cancer are high. MATERIAL AND METHODS: We used data from a cross-sectional study among 1813 men in Tanzania...
July 2013: Sexually Transmitted Diseases
https://www.readbyqxmd.com/read/23888225/human-papillomavirusassociated-cancers-as-acquired-immunodeficiency-syndrome-defining-illnesses
#18
Keith J Falter Ii, Marina Frimer, Dan Lavy, Robert Samuelson, Shohreh Shahabi
The Centers for Disease Control currently report cervical, vulvar, vaginal, anal and some head and neck cancers as human papillomavirus (HPV)-associated cancers. Only cervical cancer is listed amongst acquired immunodeficiency syndrome (AIDS) defining illnesses. All of these cancers may represent progression of the immunocompromised state with the inability to eradicate viral infection. This study reports the case of a 27-year old HIV positive female presenting with a persistent right vulvar exophytic lesion...
April 15, 2013: Rare Tumors
https://www.readbyqxmd.com/read/23852381/oral-human-papillomavirus-infection-and-head-and-neck-cancers-in-hiv-infected-individuals
#19
REVIEW
Daniel C Beachler, Gypsyamber DʼSouza
PURPOSE OF REVIEW: HIV-infected individuals are living longer due to effective antiretroviral therapy and may therefore have a greater opportunity to develop human papillomavirus (HPV)-associated malignancies. This review describes the risk factors and burden of oral HPV infection and HPV-associated head and neck cancer (HNC) among HIV-infected individuals. RECENT FINDINGS: Oral HPV infection is commonly detected in HIV-infected individuals and is elevated among those with a higher number of lifetime oral sexual partners, current tobacco use and immunosuppression...
September 2013: Current Opinion in Oncology
https://www.readbyqxmd.com/read/23612006/oral-human-papillomavirus-infection-in-hiv-negative-and-hiv-infected-men-who-have-sex-with-men-the-hiv-hpv-in-msm-h2m-study
#20
Sofie H Mooij, Hein J Boot, Arjen Gcl Speksnijder, Ineke G Stolte, Chris J L M Meijer, Peter J F Snijders, Dominique W M Verhagen, Audrey J King, Henry J C D E Vries, Wim G V Quint, Marianne A B Van Der Sande, Maarten F Schim Van Der Loeff
OBJECTIVE:: Oral infection with human papillomavirus (HPV) is associated with a subset of head and neck cancers. We compared prevalence of, and risk factors for, oral HPV infection among HIV-negative and HIV-infected men who have sex with men (MSM). DESIGN:: Analysis of baseline data from a prospective cohort study. METHODS:: MSM aged ≥18 years were recruited from 3 study sites in Amsterdam, the Netherlands. Participants completed a self-administered risk-factor questionnaire. Oral-rinse and gargle specimens were analyzed for HPV DNA and genotyped using a highly sensitive PCR and reverse line blot assay (SPF10-PCR DEIA/LiPA25 system)...
April 26, 2013: AIDS
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